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Found 4947 Enz. Inhib. hit(s) with Target = 'Insulin'
TargetInsulin-like growth factor-binding protein 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50106431(1-(3,4-Dihydroxy-benzoyl)-6,7-dihydroxy-isoquinoli...)
Affinity DataKi:  1nMAssay Description:The compound was tested for binding affinity against Insulin-like growth factor binding protein 4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50256480(CHEMBL466397 | N-(2,6-difluorophenyl)-5-(3-(2-(5-e...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity to insulin receptor by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-degrading enzyme(Homo sapiens (Human))
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50427698(CHEMBL2324206)
Affinity DataKi:  1.40nMAssay Description:Inhibition of human recombinant IDE-mediated fluorescein-Abeta-(1-40)-Lys-biotin degradationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50256480(CHEMBL466397 | N-(2,6-difluorophenyl)-5-(3-(2-(5-e...)
Affinity DataKi:  1.60nMAssay Description:Binding affinity to IGF1R by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-degrading enzyme(Homo sapiens (Human))
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50427703(CHEMBL2324220)
Affinity DataKi:  1.70nMAssay Description:Inhibition of human recombinant IDE expressed in CHO cells in presence of [125I]-insulin by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor-binding protein 2(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50106431(1-(3,4-Dihydroxy-benzoyl)-6,7-dihydroxy-isoquinoli...)
Affinity DataKi:  2.10nMAssay Description:The compound was tested for binding affinity against insulin-like growth factor binding protein 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50256478(CHEMBL507714 | N-(2,6-difluorophenyl)-3-(3-(2-(2-m...)
Affinity DataKi:  2.20nMAssay Description:Binding affinity to insulin receptor by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-degrading enzyme(Homo sapiens (Human))
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50427703(CHEMBL2324220)
Affinity DataKi:  3nMAssay Description:Inhibition of human recombinant IDE-mediated FRET1 degradationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor-binding protein 1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50106431(1-(3,4-Dihydroxy-benzoyl)-6,7-dihydroxy-isoquinoli...)
Affinity DataKi:  5.10nMAssay Description:The compound was tested for binding affinity against insulin-like growth factor binding protein 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor-binding protein 5(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50106431(1-(3,4-Dihydroxy-benzoyl)-6,7-dihydroxy-isoquinoli...)
Affinity DataKi:  5.20nMAssay Description:The compound was tested for binding affinity against Insulin-like growth factor binding protein 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50256478(CHEMBL507714 | N-(2,6-difluorophenyl)-3-(3-(2-(2-m...)
Affinity DataKi:  5.20nMAssay Description:Binding affinity to IGF1R by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor-binding protein 3(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50106431(1-(3,4-Dihydroxy-benzoyl)-6,7-dihydroxy-isoquinoli...)
Affinity DataKi:  5.60nMAssay Description:Ability to displace Insulin-Like Growth Factor (IGF-I) from its binding to human insulin-like growth factor binding protein 3 (hIGFBP-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor-binding protein 5(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50106431(1-(3,4-Dihydroxy-benzoyl)-6,7-dihydroxy-isoquinoli...)
Affinity DataKi:  5.60nMAssay Description:Ability of compound to displace Insulin-Like Growth Factor (IGF-I) from its binding to Insulin-like growth factor binding protein 5 (IGFBP-5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor-binding protein 3(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50106431(1-(3,4-Dihydroxy-benzoyl)-6,7-dihydroxy-isoquinoli...)
Affinity DataKi:  5.60nMAssay Description:Inhibitory activity against Insulin-like growth factor binding protein 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor-binding protein 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50106432((3,4-Dihydroxy-phenyl)-(3,6,7-trihydroxy-isoquinol...)
Affinity DataKi:  6.20nMAssay Description:The compound was tested for binding affinity against Insulin-like growth factor binding protein 4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor-binding protein 5(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50106443(1-(3,4-Dihydroxy-benzyl)-6,7-dihydroxy-isoquinolin...)
Affinity DataKi:  7.20nMAssay Description:Ability of compound to displace Insulin-Like Growth Factor (IGF-I) from its binding to Insulin-like growth factor binding protein 5 (IGFBP-5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor-binding protein 3(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50106443(1-(3,4-Dihydroxy-benzyl)-6,7-dihydroxy-isoquinolin...)
Affinity DataKi:  7.5nMAssay Description:Inhibitory activity against Insulin-like growth factor binding protein 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor-binding protein 3(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50128459(4-(3,4-Dihydroxy-benzyl)-6,7-dihydroxy-quinoline-2...)
Affinity DataKi:  8nMAssay Description:Ability of compound to displace Insulin-Like Growth Factor (IGF-I) from its binding to Insulin-like growth factor binding protein 3 (IGFBP-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor-binding protein 3(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50128442(1-[4-(3,5-Dichloro-phenoxy)-3-fluoro-benzoyl]-6,7-...)
Affinity DataKi:  9nMAssay Description:Ability to displace Insulin-Like Growth Factor (IGF-I) from its binding to human insulin-like growth factor binding protein 3 (hIGFBP-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor-binding protein 3(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50128432(1-(3-Fluoro-4-p-tolyloxy-benzoyl)-6,7-dihydroxy-is...)
Affinity DataKi:  9.40nMAssay Description:Ability to displace Insulin-Like Growth Factor (IGF-I) from its binding to human insulin-like growth factor binding protein 3 (hIGFBP-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor-binding protein 3(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50128450(1-[4-(3-Chloro-phenoxy)-3-fluoro-benzoyl]-6,7-dihy...)
Affinity DataKi:  11nMAssay Description:Ability to displace Insulin-Like Growth Factor (IGF-I) from its binding to human insulin-like growth factor binding protein 3 (hIGFBP-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor-binding protein 3(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50128452(6,7-Dihydroxy-1-[hydroxy-(2,4,6-trimethyl-phenyl)-...)
Affinity DataKi:  11nMAssay Description:Ability to displace Insulin-Like Growth Factor (IGF-I) from its binding to human insulin-like growth factor binding protein 3 (hIGFBP-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor-binding protein 3(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50128451(1-[4-(3,4-Dichloro-phenoxy)-3-fluoro-benzoyl]-6,7-...)
Affinity DataKi:  12nMAssay Description:Ability to displace Insulin-Like Growth Factor (IGF-I) from its binding to human insulin-like growth factor binding protein 3 (hIGFBP-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor-binding protein 3(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50106446(6,7-Dihydroxy-1-(naphthalene-2-carbonyl)-isoquinol...)
Affinity DataKi:  13nMAssay Description:Inhibitory activity against Insulin-like growth factor binding protein 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor-binding protein 5(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50128459(4-(3,4-Dihydroxy-benzyl)-6,7-dihydroxy-quinoline-2...)
Affinity DataKi:  13nMAssay Description:Ability of compound to displace Insulin-Like Growth Factor (IGF-I) from its binding to Insulin-like growth factor binding protein 5 (IGFBP-5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor-binding protein 2(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50106432((3,4-Dihydroxy-phenyl)-(3,6,7-trihydroxy-isoquinol...)
Affinity DataKi:  17nMAssay Description:The compound was tested for binding affinity against insulin-like growth factor binding protein 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor-binding protein 3(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50128430(6,7-Dihydroxy-1-[hydroxy-(4-trifluoromethyl-phenyl...)
Affinity DataKi:  18nMAssay Description:Ability to displace Insulin-Like Growth Factor (IGF-I) from its binding to human insulin-like growth factor binding protein 3 (hIGFBP-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50383168(CHEMBL2032015)
Affinity DataKi:  19nMAssay Description:Inhibition of IGF1R by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor-binding protein 3(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50128454(1-[4-(4-Chloro-phenoxy)-3-fluoro-benzoyl]-6,7-dihy...)
Affinity DataKi:  20nMAssay Description:Ability to displace Insulin-Like Growth Factor (IGF-I) from its binding to human insulin-like growth factor binding protein 3 (hIGFBP-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor-binding protein 5(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50106432((3,4-Dihydroxy-phenyl)-(3,6,7-trihydroxy-isoquinol...)
Affinity DataKi:  21nMAssay Description:The compound was tested for binding affinity against Insulin-like growth factor binding protein 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-degrading enzyme(Homo sapiens (Human))
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50427703(CHEMBL2324220)
Affinity DataKi:  22nMAssay Description:Inhibition of human recombinant IDE-mediated fluorescein-Abeta-(1-40)-Lys-biotin degradationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-degrading enzyme(Homo sapiens (Human))
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50427697(CHEMBL2324207)
Affinity DataKi:  23nMAssay Description:Inhibition of human recombinant IDE-mediated FRET1 degradationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor-binding protein 3(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50128433(1-[(3-Fluoro-phenyl)-hydroxy-methyl]-6,7-dihydroxy...)
Affinity DataKi:  24nMAssay Description:Ability to displace Insulin-Like Growth Factor (IGF-I) from its binding to human insulin-like growth factor binding protein 3 (hIGFBP-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor-binding protein 6(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50106431(1-(3,4-Dihydroxy-benzoyl)-6,7-dihydroxy-isoquinoli...)
Affinity DataKi:  24nMAssay Description:The compound was tested for binding affinity against Insulin-like growth factor binding protein 6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor-binding protein 3(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50128438(1-[(2-Chloro-phenyl)-hydroxy-methyl]-6,7-dihydroxy...)
Affinity DataKi:  25nMAssay Description:Ability to displace Insulin-Like Growth Factor (IGF-I) from its binding to human insulin-like growth factor binding protein 3 (hIGFBP-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50383206(CHEMBL2032019)
Affinity DataKi:  25nMAssay Description:Inhibition of IGF1R by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-degrading enzyme(Homo sapiens (Human))
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50427696(CHEMBL2324201)
Affinity DataKi:  26nMAssay Description:Inhibition of human recombinant IDE-mediated FRET1 degradationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50383186(CHEMBL2031898)
Affinity DataKi:  27nMAssay Description:Inhibition of IGF1R by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor-binding protein 3(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50106439(6,7-Dihydroxy-1-(naphthalene-1-carbonyl)-isoquinol...)
Affinity DataKi:  27nMAssay Description:Inhibitory activity against Insulin-like growth factor binding protein 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50383208(CHEMBL2032016)
Affinity DataKi:  27nMAssay Description:Inhibition of IGF1R by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor-binding protein 3(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50106432((3,4-Dihydroxy-phenyl)-(3,6,7-trihydroxy-isoquinol...)
Affinity DataKi:  28nMAssay Description:Inhibitory activity against Insulin-like growth factor binding protein 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Rattus norvegicus)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50318112((S)-4-(2-(3-chlorophenyl)-2-hydroxyethylamino)-3-(...)
Affinity DataKi:  28nMAssay Description:Inhibition of rat IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor-binding protein 3(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50128447(1-(3,4-Dichloro-benzoyl)-6,7-dihydroxy-isoquinolin...)
Affinity DataKi:  29nMAssay Description:Ability to displace Insulin-Like Growth Factor (IGF-I) from its binding to human insulin-like growth factor binding protein 3 (hIGFBP-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor-binding protein 3(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50106441(1-(3,4-Dihydroxy-benzyl)-isoquinoline-3,6,7-triol ...)
Affinity DataKi:  29nMAssay Description:Inhibitory activity against Insulin-like growth factor binding protein 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor-binding protein 3(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50128434(1-[4-(4-Chloro-phenylsulfanyl)-3-fluoro-benzoyl]-6...)
Affinity DataKi:  31nMAssay Description:Ability to displace Insulin-Like Growth Factor (IGF-I) from its binding to human insulin-like growth factor binding protein 3 (hIGFBP-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50383194(CHEMBL2032018)
Affinity DataKi:  31nMAssay Description:Inhibition of IGF1R by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50383191(CHEMBL2031893)
Affinity DataKi:  32nMAssay Description:Inhibition of IGF1R by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor-binding protein 3(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50128431(1-[3-Fluoro-4-(4-trifluoromethyl-phenoxy)-benzoyl]...)
Affinity DataKi:  32nMAssay Description:Ability to displace Insulin-Like Growth Factor (IGF-I) from its binding to human insulin-like growth factor binding protein 3 (hIGFBP-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor-binding protein 3(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50128446(6,7-Dihydroxy-1-(4-nitro-benzoyl)-isoquinoline-3-c...)
Affinity DataKi:  32nMAssay Description:Ability to displace Insulin-Like Growth Factor (IGF-I) from its binding to human insulin-like growth factor binding protein 3 (hIGFBP-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor-binding protein 3(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50128443(6,7-Dihydroxy-1-[hydroxy-(4-phenoxy-phenyl)-methyl...)
Affinity DataKi:  32nMAssay Description:Ability to displace Insulin-Like Growth Factor (IGF-I) from its binding to human insulin-like growth factor binding protein 3 (hIGFBP-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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