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Compile Data Set for Download or QSAR

Found 368 hits Enz. Inhib. hit(s) with Target = 'Kallikrein 7'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Kallikrein 7


(Homo sapiens)
BDBM50125021
PNG
(CHEMBL3623779)
Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N2)[C@@H](C)O
Show InChI InChI=1S/C58H92N20O20S2/c1-5-25(2)42-52(93)71-33-23-99-100-24-34(72-53(94)43(26(3)80)73-41(85)21-65-45(86)29(18-38(59)82)67-50(91)35-11-7-15-76(35)55(96)30(19-39(60)83)69-48(33)89)49(90)75-44(27(4)81)54(95)66-28(10-6-14-64-58(62)63)46(87)70-32(22-79)47(88)68-31(20-40(61)84)56(97)78-17-9-13-37(78)57(98)77-16-8-12-36(77)51(92)74-42/h25-37,42-44,79-81H,5-24H2,1-4H3,(H2,59,82)(H2,60,83)(H2,61,84)(H,65,86)(H,66,95)(H,67,91)(H,68,88)(H,69,89)(H,70,87)(H,71,93)(H,72,94)(H,73,85)(H,74,92)(H,75,90)(H4,62,63,64)/t25-,26+,27+,28-,29-,30-,31-,32-,33-,34-,35-,36-,37-,42-,43-,44-/m0/s1
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0.800n/an/an/an/an/an/an/an/a



Queensland University of Technology

Curated by ChEMBL


Assay Description
Inhibition of KLK7 (unknown origin) expressed in Pichia pastoris X33 using KHLY-pNA substrate by spectrophotometry method


J Med Chem 58: 8257-68 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01148
BindingDB Entry DOI: 10.7270/Q2PR7XSJ
More data for this
Ligand-Target Pair
Kallikrein 7


(Homo sapiens)
BDBM50124906
PNG
(CHEMBL3623776)
Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N2)[C@@H](C)O)[C@@H](C)CC
Show InChI InChI=1S/C60H97N19O19S2/c1-7-27(3)43-54(93)71-35-25-99-100-26-36(72-55(94)45(29(5)81)73-42(85)23-66-47(86)32(21-40(61)83)68-52(91)37-14-10-18-77(37)57(96)33(22-41(62)84)69-50(35)89)51(90)76-46(30(6)82)56(95)67-31(13-9-17-65-60(63)64)48(87)70-34(24-80)49(88)75-44(28(4)8-2)59(98)79-20-12-16-39(79)58(97)78-19-11-15-38(78)53(92)74-43/h27-39,43-46,80-82H,7-26H2,1-6H3,(H2,61,83)(H2,62,84)(H,66,86)(H,67,95)(H,68,91)(H,69,89)(H,70,87)(H,71,93)(H,72,94)(H,73,85)(H,74,92)(H,75,88)(H,76,90)(H4,63,64,65)/t27-,28-,29+,30+,31-,32-,33-,34-,35-,36-,37-,38-,39-,43-,44-,45-,46-/m0/s1
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17n/an/an/an/an/an/an/an/a



Queensland University of Technology

Curated by ChEMBL


Assay Description
Inhibition of KLK7 (unknown origin) expressed in Pichia pastoris X33 using KHLY-pNA substrate by spectrophotometry method


J Med Chem 58: 8257-68 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01148
BindingDB Entry DOI: 10.7270/Q2PR7XSJ
More data for this
Ligand-Target Pair
Kallikrein 7


(Homo sapiens)
BDBM113060
PNG
(US9695194, 1)
Show SMILES CCOc1cc2c(cc1OC)nc(oc2=O)-c1ccccc1SC
Show InChI InChI=1S/C18H17NO4S/c1-4-22-15-9-12-13(10-14(15)21-2)19-17(23-18(12)20)11-7-5-6-8-16(11)24-3/h5-10H,4H2,1-3H3
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48n/an/an/an/an/an/an/an/a



SIXERA PHARMA AB

US Patent


Assay Description
Materials: Recombinant human KLK7, Substrate S-2586 (Chromogenics, cat. no. 820894) KLK7 activity was determined at 37° C. in 10 mM Na phosphate ...


US Patent US9695194 (2017)


BindingDB Entry DOI: 10.7270/Q2CN723D
More data for this
Ligand-Target Pair
Kallikrein 7


(Homo sapiens)
BDBM113283
PNG
(US9695194, 8)
Show SMILES COc1ccc(c(OC)c1)-c1nc2cc3OCCCOc3cc2c(=O)o1
Show InChI InChI=1S/C19H17NO6/c1-22-11-4-5-12(15(8-11)23-2)18-20-14-10-17-16(24-6-3-7-25-17)9-13(14)19(21)26-18/h4-5,8-10H,3,6-7H2,1-2H3
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65n/an/an/an/an/an/an/an/a



SIXERA PHARMA AB

US Patent


Assay Description
Materials: Recombinant human KLK7, Substrate S-2586 (Chromogenics, cat. no. 820894) KLK7 activity was determined at 37° C. in 10 mM Na phosphate ...


US Patent US9695194 (2017)


BindingDB Entry DOI: 10.7270/Q2CN723D
More data for this
Ligand-Target Pair
Kallikrein 7


(Homo sapiens)
BDBM113065
PNG
(US9695194, 2)
Show SMILES CCOc1cc2c(cc1OC)nc(oc2=O)-c1ccccc1Cl
Show InChI InChI=1S/C17H14ClNO4/c1-3-22-15-8-11-13(9-14(15)21-2)19-16(23-17(11)20)10-6-4-5-7-12(10)18/h4-9H,3H2,1-2H3
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73n/an/an/an/an/an/an/an/a



SIXERA PHARMA AB

US Patent


Assay Description
Materials: Recombinant human KLK7, Substrate S-2586 (Chromogenics, cat. no. 820894) KLK7 activity was determined at 37° C. in 10 mM Na phosphate ...


US Patent US9695194 (2017)


BindingDB Entry DOI: 10.7270/Q2CN723D
More data for this
Ligand-Target Pair
Kallikrein 7


(Homo sapiens)
BDBM113119
PNG
(US9695194, 6)
Show SMILES COc1ccccc1-c1nc2cc3OCCCOc3cc2c(=O)o1
Show InChI InChI=1S/C18H15NO5/c1-21-14-6-3-2-5-11(14)17-19-13-10-16-15(22-7-4-8-23-16)9-12(13)18(20)24-17/h2-3,5-6,9-10H,4,7-8H2,1H3
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80n/an/an/an/an/an/an/an/a



SIXERA PHARMA AB

US Patent


Assay Description
Materials: Recombinant human KLK7, Substrate S-2586 (Chromogenics, cat. no. 820894) KLK7 activity was determined at 37° C. in 10 mM Na phosphate ...


US Patent US9695194 (2017)


BindingDB Entry DOI: 10.7270/Q2CN723D
More data for this
Ligand-Target Pair
Kallikrein 7


(Homo sapiens)
BDBM113069
PNG
(US9695194, 5)
Show SMILES CCOc1cc2c(cc1OC)nc(oc2=O)-c1ccccc1OC
Show InChI InChI=1S/C18H17NO5/c1-4-23-16-9-12-13(10-15(16)22-3)19-17(24-18(12)20)11-7-5-6-8-14(11)21-2/h5-10H,4H2,1-3H3
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85n/an/an/an/an/an/an/an/a



SIXERA PHARMA AB

US Patent


Assay Description
Materials: Recombinant human KLK7, Substrate S-2586 (Chromogenics, cat. no. 820894) KLK7 activity was determined at 37° C. in 10 mM Na phosphate ...


US Patent US9695194 (2017)


BindingDB Entry DOI: 10.7270/Q2CN723D
More data for this
Ligand-Target Pair
Kallikrein 7


(Homo sapiens)
BDBM113248
PNG
(US9695194, 7)
Show SMILES Clc1ccccc1-c1nc2cc3OCCCOc3cc2c(=O)o1
Show InChI InChI=1S/C17H12ClNO4/c18-12-5-2-1-4-10(12)16-19-13-9-15-14(21-6-3-7-22-15)8-11(13)17(20)23-16/h1-2,4-5,8-9H,3,6-7H2
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90n/an/an/an/an/an/an/an/a



SIXERA PHARMA AB

US Patent


Assay Description
Materials: Recombinant human KLK7, Substrate S-2586 (Chromogenics, cat. no. 820894) KLK7 activity was determined at 37° C. in 10 mM Na phosphate ...


US Patent US9695194 (2017)


BindingDB Entry DOI: 10.7270/Q2CN723D
More data for this
Ligand-Target Pair
Kallikrein 7


(Homo sapiens)
BDBM50289001
PNG
(2-(2-Iodo-phenyl)-6,7-dimethoxy-benzo[d][1,3]oxazi...)
Show SMILES COc1cc2nc(oc(=O)c2cc1OC)-c1ccccc1I
Show InChI InChI=1S/C16H12INO4/c1-20-13-7-10-12(8-14(13)21-2)18-15(22-16(10)19)9-5-3-4-6-11(9)17/h3-8H,1-2H3
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100n/an/an/an/an/an/an/an/a



SIXERA PHARMA AB

US Patent


Assay Description
Materials: Recombinant human KLK7, Substrate S-2586 (Chromogenics, cat. no. 820894) KLK7 activity was determined at 37° C. in 10 mM Na phosphate ...


US Patent US9695194 (2017)


BindingDB Entry DOI: 10.7270/Q2CN723D
More data for this
Ligand-Target Pair
Kallikrein 7


(Homo sapiens)
BDBM113299
PNG
(US9695194, 15)
Show SMILES COC1CC(OC)=CC=C1c1nc2cc3OCCOc3cc2c(=O)o1
Show InChI InChI=1S/C18H17NO6/c1-21-10-3-4-11(14(7-10)22-2)17-19-13-9-16-15(23-5-6-24-16)8-12(13)18(20)25-17/h3-4,8-9,14H,5-7H2,1-2H3
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105n/an/an/an/an/an/an/an/a



SIXERA PHARMA AB

US Patent


Assay Description
Materials: Recombinant human KLK7, Substrate S-2586 (Chromogenics, cat. no. 820894) KLK7 activity was determined at 37° C. in 10 mM Na phosphate ...


US Patent US9695194 (2017)


BindingDB Entry DOI: 10.7270/Q2CN723D
More data for this
Ligand-Target Pair
Kallikrein 7


(Homo sapiens)
BDBM113067
PNG
(US9695194, 3)
Show SMILES CCOc1cc2c(cc1OC)nc(oc2=O)-c1ccc(OC)cc1OC
Show InChI InChI=1S/C19H19NO6/c1-5-25-17-9-13-14(10-16(17)24-4)20-18(26-19(13)21)12-7-6-11(22-2)8-15(12)23-3/h6-10H,5H2,1-4H3
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116n/an/an/an/an/an/an/an/a



SIXERA PHARMA AB

US Patent


Assay Description
Materials: Recombinant human KLK7, Substrate S-2586 (Chromogenics, cat. no. 820894) KLK7 activity was determined at 37° C. in 10 mM Na phosphate ...


US Patent US9695194 (2017)


BindingDB Entry DOI: 10.7270/Q2CN723D
More data for this
Ligand-Target Pair
Kallikrein 7


(Homo sapiens)
BDBM113295
PNG
(US9695194, 12)
Show SMILES COc1cc2nc(oc(=O)c2cc1OC)-c1ccccc1SC
Show InChI InChI=1S/C17H15NO4S/c1-20-13-8-11-12(9-14(13)21-2)18-16(22-17(11)19)10-6-4-5-7-15(10)23-3/h4-9H,1-3H3
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147n/an/an/an/an/an/an/an/a



SIXERA PHARMA AB

US Patent


Assay Description
Materials: Recombinant human KLK7, Substrate S-2586 (Chromogenics, cat. no. 820894) KLK7 activity was determined at 37° C. in 10 mM Na phosphate ...


US Patent US9695194 (2017)


BindingDB Entry DOI: 10.7270/Q2CN723D
More data for this
Ligand-Target Pair
Kallikrein 7


(Homo sapiens)
BDBM113300
PNG
(US9695194, 16)
Show SMILES Clc1ccccc1-c1nc2cc3OCCOc3cc2c(=O)o1
Show InChI InChI=1S/C16H10ClNO4/c17-11-4-2-1-3-9(11)15-18-12-8-14-13(20-5-6-21-14)7-10(12)16(19)22-15/h1-4,7-8H,5-6H2
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149n/an/an/an/an/an/an/an/a



SIXERA PHARMA AB

US Patent


Assay Description
Materials: Recombinant human KLK7, Substrate S-2586 (Chromogenics, cat. no. 820894) KLK7 activity was determined at 37° C. in 10 mM Na phosphate ...


US Patent US9695194 (2017)


BindingDB Entry DOI: 10.7270/Q2CN723D
More data for this
Ligand-Target Pair
Kallikrein 7


(Homo sapiens)
BDBM113296
PNG
(US9695194, 13)
Show SMILES COc1ccccc1-c1nc2cc3OCCOc3cc2c(=O)o1
Show InChI InChI=1S/C17H13NO5/c1-20-13-5-3-2-4-10(13)16-18-12-9-15-14(21-6-7-22-15)8-11(12)17(19)23-16/h2-5,8-9H,6-7H2,1H3
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155n/an/an/an/an/an/an/an/a



SIXERA PHARMA AB

US Patent


Assay Description
Materials: Recombinant human KLK7, Substrate S-2586 (Chromogenics, cat. no. 820894) KLK7 activity was determined at 37° C. in 10 mM Na phosphate ...


US Patent US9695194 (2017)


BindingDB Entry DOI: 10.7270/Q2CN723D
More data for this
Ligand-Target Pair
Kallikrein 7


(Homo sapiens)
BDBM113301
PNG
(US9695194, 17)
Show SMILES COc1ccc(c(OC)c1)-c1nc2cc(OC)c(OC)cc2c(=O)o1
Show InChI InChI=1S/C18H17NO6/c1-21-10-5-6-11(14(7-10)22-2)17-19-13-9-16(24-4)15(23-3)8-12(13)18(20)25-17/h5-9H,1-4H3
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175n/an/an/an/an/an/an/an/a



SIXERA PHARMA AB

US Patent


Assay Description
Materials: Recombinant human KLK7, Substrate S-2586 (Chromogenics, cat. no. 820894) KLK7 activity was determined at 37° C. in 10 mM Na phosphate ...


US Patent US9695194 (2017)


BindingDB Entry DOI: 10.7270/Q2CN723D
More data for this
Ligand-Target Pair
Kallikrein 7


(Homo sapiens)
BDBM113297
PNG
(US9695194, 14)
Show SMILES CS(=O)(=O)c1ccccc1-c1nc2cc3OCCOc3cc2c(=O)o1
Show InChI InChI=1S/C17H13NO6S/c1-25(20,21)15-5-3-2-4-10(15)16-18-12-9-14-13(22-6-7-23-14)8-11(12)17(19)24-16/h2-5,8-9H,6-7H2,1H3
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183n/an/an/an/an/an/an/an/a



SIXERA PHARMA AB

US Patent


Assay Description
Materials: Recombinant human KLK7, Substrate S-2586 (Chromogenics, cat. no. 820894) KLK7 activity was determined at 37° C. in 10 mM Na phosphate ...


US Patent US9695194 (2017)


BindingDB Entry DOI: 10.7270/Q2CN723D
More data for this
Ligand-Target Pair
Kallikrein 7


(Homo sapiens)
BDBM113293
PNG
(US9695194, 10)
Show SMILES CS(=O)(=O)c1ccccc1-c1nc2cc3OCCCOc3cc2c(=O)o1
Show InChI InChI=1S/C18H15NO6S/c1-26(21,22)16-6-3-2-5-11(16)17-19-13-10-15-14(23-7-4-8-24-15)9-12(13)18(20)25-17/h2-3,5-6,9-10H,4,7-8H2,1H3
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188n/an/an/an/an/an/an/an/a



SIXERA PHARMA AB

US Patent


Assay Description
Materials: Recombinant human KLK7, Substrate S-2586 (Chromogenics, cat. no. 820894) KLK7 activity was determined at 37° C. in 10 mM Na phosphate ...


US Patent US9695194 (2017)


BindingDB Entry DOI: 10.7270/Q2CN723D
More data for this
Ligand-Target Pair
Kallikrein 7


(Homo sapiens)
BDBM113292
PNG
(US9695194, 9)
Show SMILES CSc1ccccc1-c1nc2cc3OCCCOc3cc2c(=O)o1
Show InChI InChI=1S/C18H15NO4S/c1-24-16-6-3-2-5-11(16)17-19-13-10-15-14(21-7-4-8-22-15)9-12(13)18(20)23-17/h2-3,5-6,9-10H,4,7-8H2,1H3
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228n/an/an/an/an/an/an/an/a



SIXERA PHARMA AB

US Patent


Assay Description
Materials: Recombinant human KLK7, Substrate S-2586 (Chromogenics, cat. no. 820894) KLK7 activity was determined at 37° C. in 10 mM Na phosphate ...


US Patent US9695194 (2017)


BindingDB Entry DOI: 10.7270/Q2CN723D
More data for this
Ligand-Target Pair
Kallikrein 7


(Homo sapiens)
BDBM113068
PNG
(US9695194, 4)
Show SMILES CCOc1cc2c(cc1OC)nc(oc2=O)-c1ccccc1S(C)(=O)=O
Show InChI InChI=1S/C18H17NO6S/c1-4-24-15-9-12-13(10-14(15)23-2)19-17(25-18(12)20)11-7-5-6-8-16(11)26(3,21)22/h5-10H,4H2,1-3H3
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230n/an/an/an/an/an/an/an/a



SIXERA PHARMA AB

US Patent


Assay Description
Materials: Recombinant human KLK7, Substrate S-2586 (Chromogenics, cat. no. 820894) KLK7 activity was determined at 37° C. in 10 mM Na phosphate ...


US Patent US9695194 (2017)


BindingDB Entry DOI: 10.7270/Q2CN723D
More data for this
Ligand-Target Pair
Kallikrein 7


(Homo sapiens)
BDBM50446218
PNG
(CHEMBL3109166)
Show SMILES CC(C)(C)OC(=O)N[C@@H](CC(=O)OCc1ccccc1)C(=O)O[C@@H]1CO[C@@H]2[C@@H](CO[C@H]12)OCc1ccccc1
Show InChI InChI=1S/C29H35NO9/c1-29(2,3)39-28(33)30-21(14-24(31)35-16-20-12-8-5-9-13-20)27(32)38-23-18-37-25-22(17-36-26(23)25)34-15-19-10-6-4-7-11-19/h4-13,21-23,25-26H,14-18H2,1-3H3,(H,30,33)/t21-,22+,23+,25+,26+/m0/s1
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1.30E+3n/an/an/an/an/an/an/an/a


TBA

Assay Description
Competitive inhibition of human recombinant KLK7 expressed in baculovirus-infected insect cell system using Abz-KLYSSKQ-Eddnp as substrate incubated ...


Citation and Details

Article DOI: 10.1021/ml4003698
BindingDB Entry DOI: 10.7270/Q2W37XSV
More data for this
Ligand-Target Pair
Kallikrein 7


(Homo sapiens)
BDBM113294
PNG
(US9695194, 11)
Show SMILES CC(C)c1ccc(-c2nc3cc4OCCCOc4cc3c(=O)o2)c(c1)C(C)C
Show InChI InChI=1S/C23H25NO4/c1-13(2)15-6-7-16(17(10-15)14(3)4)22-24-19-12-21-20(26-8-5-9-27-21)11-18(19)23(25)28-22/h6-7,10-14H,5,8-9H2,1-4H3
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1.37E+3n/an/an/an/an/an/an/an/a



SIXERA PHARMA AB

US Patent


Assay Description
Materials: Recombinant human KLK7, Substrate S-2586 (Chromogenics, cat. no. 820894) KLK7 activity was determined at 37° C. in 10 mM Na phosphate ...


US Patent US9695194 (2017)


BindingDB Entry DOI: 10.7270/Q2CN723D
More data for this
Ligand-Target Pair
Kallikrein 7


(Homo sapiens)
BDBM50446219
PNG
(CHEMBL3109165)
Show SMILES CC(C)(C)OC(=O)N[C@@H](CCCCNC(=O)OCc1ccccc1)C(=O)O[C@@H]1CO[C@@H]2[C@@H](CO[C@H]12)OCc1ccccc1
Show InChI InChI=1S/C32H42N2O9/c1-32(2,3)43-31(37)34-24(16-10-11-17-33-30(36)41-19-23-14-8-5-9-15-23)29(35)42-26-21-40-27-25(20-39-28(26)27)38-18-22-12-6-4-7-13-22/h4-9,12-15,24-28H,10-11,16-21H2,1-3H3,(H,33,36)(H,34,37)/t24-,25+,26+,27+,28+/m0/s1
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1.40E+3n/an/an/an/an/an/an/an/a


TBA

Assay Description
Competitive inhibition of human recombinant KLK7 expressed in baculovirus-infected insect cell system using Abz-KLYSSKQ-Eddnp as substrate incubated ...


Citation and Details

Article DOI: 10.1021/ml4003698
BindingDB Entry DOI: 10.7270/Q2W37XSV
More data for this
Ligand-Target Pair
Kallikrein 7


(Homo sapiens)
BDBM50446227
PNG
(CHEMBL3109056)
Show SMILES O=C(N[C@H]1CO[C@@H]2[C@@H](CO[C@H]12)OCc1ccccc1)C(\NC(=O)c1ccccc1)=C\c1cccs1
Show InChI InChI=1S/C27H26N2O5S/c30-26(19-10-5-2-6-11-19)28-21(14-20-12-7-13-35-20)27(31)29-22-16-33-25-23(17-34-24(22)25)32-15-18-8-3-1-4-9-18/h1-14,22-25H,15-17H2,(H,28,30)(H,29,31)/b21-14-/t22-,23+,24+,25+/m0/s1
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1.80E+3n/an/an/an/an/an/an/an/a


TBA

Assay Description
Competitive inhibition of human recombinant KLK7 expressed in baculovirus-infected insect cell system using Abz-KLYSSKQ-Eddnp as substrate incubated ...


Citation and Details

Article DOI: 10.1021/ml4003698
BindingDB Entry DOI: 10.7270/Q2W37XSV
More data for this
Ligand-Target Pair
Kallikrein 7


(Homo sapiens)
BDBM50391075
PNG
(CHEMBL2087343)
Show SMILES O=C(N[C@@H]1CO[C@@H]2[C@@H](CO[C@H]12)OCc1ccccc1)C(\NC(=O)c1ccccc1)=C\c1cccs1
Show InChI InChI=1S/C27H26N2O5S/c30-26(19-10-5-2-6-11-19)28-21(14-20-12-7-13-35-20)27(31)29-22-16-33-25-23(17-34-24(22)25)32-15-18-8-3-1-4-9-18/h1-14,22-25H,15-17H2,(H,28,30)(H,29,31)/b21-14-/t22-,23-,24-,25-/m1/s1
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1.80E+3n/an/an/an/an/an/an/an/a



Universidade Federal do Tri£ngulo Mineiro

Curated by ChEMBL


Assay Description
Competitive inhibition of recombinant human KLK7 expressed in insect cell/baculovirus using Abz-KLYSSKQ-EDDnp as substrate by Dixon plot analysis


Bioorg Med Chem Lett 22: 6072-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.047
BindingDB Entry DOI: 10.7270/Q2SF2X8R
More data for this
Ligand-Target Pair
Kallikrein 7


(Homo sapiens)
BDBM50446220
PNG
(CHEMBL3109164)
Show SMILES O=C(O[C@@H]1CO[C@@H]2[C@@H](CO[C@H]12)OCc1ccccc1)[C@H]1CCCN1C(=O)OCc1ccccc1
Show InChI InChI=1S/C26H29NO7/c28-25(20-12-7-13-27(20)26(29)33-15-19-10-5-2-6-11-19)34-22-17-32-23-21(16-31-24(22)23)30-14-18-8-3-1-4-9-18/h1-6,8-11,20-24H,7,12-17H2/t20-,21-,22-,23-,24-/m1/s1
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1.90E+3n/an/an/an/an/an/an/an/a


TBA

Assay Description
Competitive inhibition of human recombinant KLK7 expressed in baculovirus-infected insect cell system using Abz-KLYSSKQ-Eddnp as substrate incubated ...


Citation and Details

Article DOI: 10.1021/ml4003698
BindingDB Entry DOI: 10.7270/Q2W37XSV
More data for this
Ligand-Target Pair
Kallikrein 7


(Homo sapiens)
BDBM50446224
PNG
(CHEMBL3109160)
Show SMILES CC(C)(C)OC(=O)N[C@H](COCc1ccccc1)C(=O)O[C@@H]1CO[C@@H]2[C@@H](CO[C@H]12)OCc1ccccc1
Show InChI InChI=1S/C28H35NO8/c1-28(2,3)37-27(31)29-21(16-32-14-19-10-6-4-7-11-19)26(30)36-23-18-35-24-22(17-34-25(23)24)33-15-20-12-8-5-9-13-20/h4-13,21-25H,14-18H2,1-3H3,(H,29,31)/t21-,22-,23-,24-,25-/m1/s1
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2.30E+3n/an/an/an/an/an/an/an/a


TBA

Assay Description
Competitive inhibition of human recombinant KLK7 expressed in baculovirus-infected insect cell system using Abz-KLYSSKQ-Eddnp as substrate incubated ...


Citation and Details

Article DOI: 10.1021/ml4003698
BindingDB Entry DOI: 10.7270/Q2W37XSV
More data for this
Ligand-Target Pair
Kallikrein 7


(Homo sapiens)
BDBM50446228
PNG
(CHEMBL3109061)
Show SMILES CC(C)(C)OC(=O)N[C@H](CCCN=C(NC(=O)OCc1ccccc1)NC(=O)OCc1ccccc1)C(=O)N[C@H]1CO[C@@H]2[C@@H](CO[C@H]12)OCc1ccccc1
Show InChI InChI=1S/C40H49N5O10/c1-40(2,3)55-39(49)43-30(35(46)42-31-25-51-34-32(26-52-33(31)34)50-22-27-14-7-4-8-15-27)20-13-21-41-36(44-37(47)53-23-28-16-9-5-10-17-28)45-38(48)54-24-29-18-11-6-12-19-29/h4-12,14-19,30-34H,13,20-26H2,1-3H3,(H,42,46)(H,43,49)(H2,41,44,45,47,48)/t30-,31+,32-,33-,34-/m1/s1
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2.40E+3n/an/an/an/an/an/an/an/a


TBA

Assay Description
Competitive inhibition of human recombinant KLK7 expressed in baculovirus-infected insect cell system using Abz-KLYSSKQ-Eddnp as substrate incubated ...


Citation and Details

Article DOI: 10.1021/ml4003698
BindingDB Entry DOI: 10.7270/Q2W37XSV
More data for this
Ligand-Target Pair
Kallikrein 7


(Homo sapiens)
BDBM50446221
PNG
(CHEMBL3109163)
Show SMILES O=C(O[C@@H]1CO[C@@H]2[C@@H](CO[C@H]12)OCc1ccccc1)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)OCc1ccccc1
Show InChI InChI=1S/C35H38N2O8/c38-33(28-17-10-18-37(28)35(40)44-21-26-15-8-3-9-16-26)36-27(19-24-11-4-1-5-12-24)34(39)45-30-23-43-31-29(22-42-32(30)31)41-20-25-13-6-2-7-14-25/h1-9,11-16,27-32H,10,17-23H2,(H,36,38)/t27-,28-,29+,30+,31+,32+/m0/s1
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2.80E+3n/an/an/an/an/an/an/an/a


TBA

Assay Description
Competitive inhibition of human recombinant KLK7 expressed in baculovirus-infected insect cell system using Abz-KLYSSKQ-Eddnp as substrate incubated ...


Citation and Details

Article DOI: 10.1021/ml4003698
BindingDB Entry DOI: 10.7270/Q2W37XSV
More data for this
Ligand-Target Pair
Kallikrein 7


(Homo sapiens)
BDBM50446211
PNG
(CHEMBL3109058)
Show SMILES CC(C)(C)OC(=O)N[C@@H](CCCCNC(=O)OCc1ccccc1)C(=O)N[C@H]1CO[C@@H]2[C@@H](CO[C@H]12)OCc1ccccc1
Show InChI InChI=1S/C32H43N3O8/c1-32(2,3)43-31(38)35-24(16-10-11-17-33-30(37)42-19-23-14-8-5-9-15-23)29(36)34-25-20-40-28-26(21-41-27(25)28)39-18-22-12-6-4-7-13-22/h4-9,12-15,24-28H,10-11,16-21H2,1-3H3,(H,33,37)(H,34,36)(H,35,38)/t24-,25-,26+,27+,28+/m0/s1
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2.90E+3n/an/an/an/an/an/an/an/a


TBA

Assay Description
Competitive inhibition of human recombinant KLK7 expressed in baculovirus-infected insect cell system using Abz-KLYSSKQ-Eddnp as substrate incubated ...


Citation and Details

Article DOI: 10.1021/ml4003698
BindingDB Entry DOI: 10.7270/Q2W37XSV
More data for this
Ligand-Target Pair
Kallikrein 7


(Homo sapiens)
BDBM50391078
PNG
(CHEMBL2087346)
Show SMILES O=C(N[C@@H]1CO[C@@H]2[C@@H](CO[C@H]12)OCc1ccccc1)C(\NC(=O)c1ccccc1)=C\c1ccco1
Show InChI InChI=1S/C27H26N2O6/c30-26(19-10-5-2-6-11-19)28-21(14-20-12-7-13-32-20)27(31)29-22-16-34-25-23(17-35-24(22)25)33-15-18-8-3-1-4-9-18/h1-14,22-25H,15-17H2,(H,28,30)(H,29,31)/b21-14-/t22-,23-,24-,25-/m1/s1
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3.00E+3n/an/an/an/an/an/an/an/a



Universidade Federal do Tri£ngulo Mineiro

Curated by ChEMBL


Assay Description
Competitive inhibition of recombinant human KLK7 expressed in insect cell/baculovirus using Abz-KLYSSKQ-EDDnp as substrate by Dixon plot analysis


Bioorg Med Chem Lett 22: 6072-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.047
BindingDB Entry DOI: 10.7270/Q2SF2X8R
More data for this
Ligand-Target Pair
Kallikrein 7


(Homo sapiens)
BDBM50446229
PNG
(CHEMBL3109060)
Show SMILES CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@H]1CO[C@@H]2[C@@H](CO[C@H]12)OCc1ccccc1
Show InChI InChI=1S/C35H41N3O7/c1-23(2)30(38-35(41)45-20-26-16-10-5-11-17-26)34(40)36-27(18-24-12-6-3-7-13-24)33(39)37-28-21-43-32-29(22-44-31(28)32)42-19-25-14-8-4-9-15-25/h3-17,23,27-32H,18-22H2,1-2H3,(H,36,40)(H,37,39)(H,38,41)/t27-,28+,29-,30+,31-,32-/m1/s1
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3.80E+3n/an/an/an/an/an/an/an/a


TBA

Assay Description
Competitive inhibition of human recombinant KLK7 expressed in baculovirus-infected insect cell system using Abz-KLYSSKQ-Eddnp as substrate incubated ...


Citation and Details

Article DOI: 10.1021/ml4003698
BindingDB Entry DOI: 10.7270/Q2W37XSV
More data for this
Ligand-Target Pair
Kallikrein 7


(Homo sapiens)
BDBM50446230
PNG
(CHEMBL3109059)
Show SMILES Cc1ccc(cc1)S(=O)(=O)n1cnc(C[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H]2CO[C@@H]3[C@@H](CO[C@H]23)OCc2ccccc2)c1
Show InChI InChI=1S/C31H38N4O8S/c1-20-10-12-23(13-11-20)44(38,39)35-15-22(32-19-35)14-24(34-30(37)43-31(2,3)4)29(36)33-25-17-41-28-26(18-42-27(25)28)40-16-21-8-6-5-7-9-21/h5-13,15,19,24-28H,14,16-18H2,1-4H3,(H,33,36)(H,34,37)/t24-,25-,26+,27+,28+/m0/s1
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4.40E+3n/an/an/an/an/an/an/an/a


TBA

Assay Description
Competitive inhibition of human recombinant KLK7 expressed in baculovirus-infected insect cell system using Abz-KLYSSKQ-Eddnp as substrate incubated ...


Citation and Details

Article DOI: 10.1021/ml4003698
BindingDB Entry DOI: 10.7270/Q2W37XSV
More data for this
Ligand-Target Pair
Kallikrein 7


(Homo sapiens)
BDBM50355086
PNG
(CHEMBL1834753)
Show SMILES COc1cc2c(OC)c3cc(C)oc(=O)c3c(O)c2c(O)c1-c1c(OC)cc2c(OC)c3cc(C)oc(=O)c3c(O)c2c1O
Show InChI InChI=1S/C32H26O12/c1-11-7-13-21(31(37)43-11)25(33)19-15(29(13)41-5)9-17(39-3)23(27(19)35)24-18(40-4)10-16-20(28(24)36)26(34)22-14(30(16)42-6)8-12(2)44-32(22)38/h7-10,33-36H,1-6H3
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1.22E+4n/an/an/an/an/an/an/an/a



Quaid-I-Azam University

Curated by ChEMBL


Assay Description
Competitive inhibition of human kallikrein-7


Eur J Med Chem 116: 290-317 (2016)


Article DOI: 10.1016/j.ejmech.2016.03.025
BindingDB Entry DOI: 10.7270/Q2NZ89HN
More data for this
Ligand-Target Pair
Kallikrein 7


(Homo sapiens)
BDBM50167828
PNG
(CHEMBL3798972)
Show SMILES COC1=C(C(=O)c2c(O)c3C(=O)O[C@@H](C)Cc3c(O)c2C1=O)c1c(O)c2C(=O)C3=C(C[C@H](C)OC3=O)C(=O)c2cc1OC
Show InChI InChI=1S/C30H22O13/c1-8-5-10-15(29(38)42-8)23(33)14-12(21(10)31)7-13(40-3)17(24(14)34)20-26(36)19-18(27(37)28(20)41-4)22(32)11-6-9(2)43-30(39)16(11)25(19)35/h7-9,32,34-35H,5-6H2,1-4H3/t8-,9-/m0/s1
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1.22E+4n/an/an/an/an/an/an/an/a



Quaid-I-Azam University

Curated by ChEMBL


Assay Description
Competitive inhibition of human kallikrein-7


Eur J Med Chem 116: 290-317 (2016)


Article DOI: 10.1016/j.ejmech.2016.03.025
BindingDB Entry DOI: 10.7270/Q2NZ89HN
More data for this
Ligand-Target Pair
Kallikrein 7


(Homo sapiens)
BDBM50355086
PNG
(CHEMBL1834753)
Show SMILES COc1cc2c(OC)c3cc(C)oc(=O)c3c(O)c2c(O)c1-c1c(OC)cc2c(OC)c3cc(C)oc(=O)c3c(O)c2c1O
Show InChI InChI=1S/C32H26O12/c1-11-7-13-21(31(37)43-11)25(33)19-15(29(13)41-5)9-17(39-3)23(27(19)35)24-18(40-4)10-16-20(28(24)36)26(34)22-14(30(16)42-6)8-12(2)44-32(22)38/h7-10,33-36H,1-6H3
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1.22E+4n/an/an/an/an/an/an/an/a



Universidade Federal do Tri£ngulo Mineiro

Curated by ChEMBL


Assay Description
Inhibition of human kallikrein 7 using Abz-KLYSSKQ-EDDnp as substrate by Lineweaver-Burk plot analysis


Bioorg Med Chem Lett 21: 6112-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.08.044
BindingDB Entry DOI: 10.7270/Q24M94ZP
More data for this
Ligand-Target Pair
Kallikrein 7


(Homo sapiens)
BDBM50444601
PNG
(CHEMBL3099881)
Show SMILES Nc1ccc2nc(SCc3nc4ccccc4c(=O)n3-c3cccc(c3)C(F)(F)F)[nH]c2c1
Show InChI InChI=1S/C23H16F3N5OS/c24-23(25,26)13-4-3-5-15(10-13)31-20(28-17-7-2-1-6-16(17)21(31)32)12-33-22-29-18-9-8-14(27)11-19(18)30-22/h1-11H,12,27H2,(H,29,30)
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1.50E+4n/an/an/an/an/an/an/an/a



Universit£ Pierre et Marie Curie

Curated by ChEMBL


Assay Description
Mixed-type inhibition of human kallikrein7 using Suc-Leu-Leu-Val-Tyr-AMC as substrate assessed as enzyme-inhibitor complex after 15 to 60 mins by Lin...


Eur J Med Chem 70: 661-8 (2013)


Article DOI: 10.1016/j.ejmech.2013.10.040
BindingDB Entry DOI: 10.7270/Q21837Z8
More data for this
Ligand-Target Pair
Kallikrein 7


(Homo sapiens)
BDBM50446212
PNG
(CHEMBL3109057)
Show SMILES O=C(N[C@H]1CO[C@@H]2[C@@H](CO[C@H]12)OCc1ccccc1)[C@H]1CCCN1C(=O)OCc1ccccc1
Show InChI InChI=1S/C26H30N2O6/c29-25(21-12-7-13-28(21)26(30)34-15-19-10-5-2-6-11-19)27-20-16-32-24-22(17-33-23(20)24)31-14-18-8-3-1-4-9-18/h1-6,8-11,20-24H,7,12-17H2,(H,27,29)/t20-,21+,22+,23+,24+/m0/s1
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1.51E+4n/an/an/an/an/an/an/an/a


TBA

Assay Description
Competitive inhibition of human recombinant KLK7 expressed in baculovirus-infected insect cell system using Abz-KLYSSKQ-Eddnp as substrate incubated ...


Citation and Details

Article DOI: 10.1021/ml4003698
BindingDB Entry DOI: 10.7270/Q2W37XSV
More data for this
Ligand-Target Pair
Kallikrein 7


(Homo sapiens)
BDBM50446226
PNG
(CHEMBL3109158)
Show SMILES CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)O[C@@H]1CO[C@@H]2[C@@H](CO[C@H]12)OCc1ccccc1
Show InChI InChI=1S/C23H31NO7/c1-23(2,3)31-22(26)24-11-7-10-16(24)21(25)30-18-14-29-19-17(13-28-20(18)19)27-12-15-8-5-4-6-9-15/h4-6,8-9,16-20H,7,10-14H2,1-3H3/t16-,17+,18+,19+,20+/m0/s1
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PubMed
1.56E+4n/an/an/an/an/an/an/an/a


TBA

Assay Description
Competitive inhibition of human recombinant KLK7 expressed in baculovirus-infected insect cell system using Abz-KLYSSKQ-Eddnp as substrate incubated ...


Citation and Details

Article DOI: 10.1021/ml4003698
BindingDB Entry DOI: 10.7270/Q2W37XSV
More data for this
Ligand-Target Pair
Kallikrein 7


(Homo sapiens)
BDBM50446223
PNG
(CHEMBL3109161)
Show SMILES CSCC[C@H](NC(=O)OC(C)(C)C)C(=O)O[C@@H]1CO[C@@H]2[C@@H](CO[C@H]12)OCc1ccccc1
Show InChI InChI=1S/C23H33NO7S/c1-23(2,3)31-22(26)24-16(10-11-32-4)21(25)30-18-14-29-19-17(13-28-20(18)19)27-12-15-8-6-5-7-9-15/h5-9,16-20H,10-14H2,1-4H3,(H,24,26)/t16-,17+,18+,19+,20+/m0/s1
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1.84E+4n/an/an/an/an/an/an/an/a


TBA

Assay Description
Competitive inhibition of human recombinant KLK7 expressed in baculovirus-infected insect cell system using Abz-KLYSSKQ-Eddnp as substrate incubated ...


Citation and Details

Article DOI: 10.1021/ml4003698
BindingDB Entry DOI: 10.7270/Q2W37XSV
More data for this
Ligand-Target Pair
Kallikrein 7


(Homo sapiens)
BDBM50073221
PNG
(CHEMBL3408420)
Show SMILES COc1ccc(cc1OC)C1=Nc2nc3ccccn3c2C(=O)[C@H](Cc2ccccc2)N1
Show InChI InChI=1S/C25H22N4O3/c1-31-19-12-11-17(15-20(19)32-2)24-26-18(14-16-8-4-3-5-9-16)23(30)22-25(28-24)27-21-10-6-7-13-29(21)22/h3-13,15,18H,14H2,1-2H3,(H,26,28)/t18-/m0/s1
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2.70E+4n/an/an/an/an/an/an/an/a



Universit£ de Montpellier

Curated by ChEMBL


Assay Description
Competitive inhibition of human KLK7 using Suc-Leu-Leu-Val-Tyr-AMC as substrate by Lineweaver-Burk plot analysis


Eur J Med Chem 93: 202-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.008
BindingDB Entry DOI: 10.7270/Q27P913V
More data for this
Ligand-Target Pair
Kallikrein 7


(Homo sapiens)
BDBM50355088
PNG
(CHEMBL1834754)
Show SMILES COc1cc2cc3C[C@@H](C)OC(=O)c3c(O)c2c(O)c1-c1c(OC)cc2cc3C[C@@H](C)OC(=O)c3c(O)c2c1O
Show InChI InChI=1S/C30H26O10/c1-11-5-13-7-15-9-17(37-3)23(27(33)19(15)25(31)21(13)29(35)39-11)24-18(38-4)10-16-8-14-6-12(2)40-30(36)22(14)26(32)20(16)28(24)34/h7-12,31-34H,5-6H2,1-4H3/t11-,12-/m1/s1
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3.72E+4n/an/an/an/an/an/an/an/a



Universidade Federal do Tri£ngulo Mineiro

Curated by ChEMBL


Assay Description
Inhibition of human kallikrein 7 using Abz-KLYSSKQ-EDDnp as substrate by Lineweaver-Burk plot analysis


Bioorg Med Chem Lett 21: 6112-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.08.044
BindingDB Entry DOI: 10.7270/Q24M94ZP
More data for this
Ligand-Target Pair
Kallikrein 7


(Homo sapiens)
BDBM50444601
PNG
(CHEMBL3099881)
Show SMILES Nc1ccc2nc(SCc3nc4ccccc4c(=O)n3-c3cccc(c3)C(F)(F)F)[nH]c2c1
Show InChI InChI=1S/C23H16F3N5OS/c24-23(25,26)13-4-3-5-15(10-13)31-20(28-17-7-2-1-6-16(17)21(31)32)12-33-22-29-18-9-8-14(27)11-19(18)30-22/h1-11H,12,27H2,(H,29,30)
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4.40E+4n/an/an/an/an/an/an/an/a



Universit£ Pierre et Marie Curie

Curated by ChEMBL


Assay Description
Mixed-type inhibition of human kallikrein7 using Suc-Leu-Leu-Val-Tyr-AMC as substrate assessed as enzyme-substrate-inhibitor complex after 15 to 60 m...


Eur J Med Chem 70: 661-8 (2013)


Article DOI: 10.1016/j.ejmech.2013.10.040
BindingDB Entry DOI: 10.7270/Q21837Z8
More data for this
Ligand-Target Pair
Kallikrein 7


(Homo sapiens)
BDBM50444600
PNG
(CHEMBL1462676)
Show SMILES CNC(=O)c1ccc(Nc2nnc(-c3ccc(O)cc3)c3ccccc23)cc1
Show InChI InChI=1S/C22H18N4O2/c1-23-22(28)15-6-10-16(11-7-15)24-21-19-5-3-2-4-18(19)20(25-26-21)14-8-12-17(27)13-9-14/h2-13,27H,1H3,(H,23,28)(H,24,26)
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5.00E+4n/an/an/an/an/an/an/an/a



Universit£ Pierre et Marie Curie

Curated by ChEMBL


Assay Description
Mixed-type inhibition of human kallikrein7 using Suc-Leu-Leu-Val-Tyr-AMC as substrate assessed as enzyme-inhibitor complex after 15 to 60 mins by Lin...


Eur J Med Chem 70: 661-8 (2013)


Article DOI: 10.1016/j.ejmech.2013.10.040
BindingDB Entry DOI: 10.7270/Q21837Z8
More data for this
Ligand-Target Pair
Kallikrein 7


(Homo sapiens)
BDBM50073222
PNG
(CHEMBL3125572)
Show SMILES Cc1ccccc1C1=Nc2nc3ccccn3c2C(=O)[C@H](Cc2ccccc2)N1
Show InChI InChI=1S/C24H20N4O/c1-16-9-5-6-12-18(16)23-25-19(15-17-10-3-2-4-11-17)22(29)21-24(27-23)26-20-13-7-8-14-28(20)21/h2-14,19H,15H2,1H3,(H,25,27)/t19-/m0/s1
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5.06E+4n/an/an/an/an/an/an/an/a



Universit£ de Montpellier

Curated by ChEMBL


Assay Description
Competitive inhibition of human KLK7 using Suc-Leu-Leu-Val-Tyr-AMC as substrate by Lineweaver-Burk plot analysis


Eur J Med Chem 93: 202-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.008
BindingDB Entry DOI: 10.7270/Q27P913V
More data for this
Ligand-Target Pair
Kallikrein 7


(Homo sapiens)
BDBM50444598
PNG
(CHEMBL3099878)
Show SMILES COc1cc(\C=C(\C#N)c2nc3ccccc3[nH]2)ccc1OCC(=O)N1CCOCC1
Show InChI InChI=1S/C23H22N4O4/c1-29-21-13-16(6-7-20(21)31-15-22(28)27-8-10-30-11-9-27)12-17(14-24)23-25-18-4-2-3-5-19(18)26-23/h2-7,12-13H,8-11,15H2,1H3,(H,25,26)/b17-12-
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5.50E+4n/an/an/an/an/an/an/an/a



Universit£ Pierre et Marie Curie

Curated by ChEMBL


Assay Description
Mixed-type inhibition of human kallikrein7 using Suc-Leu-Leu-Val-Tyr-AMC as substrate assessed as enzyme-inhibitor complex after 15 to 60 mins by Lin...


Eur J Med Chem 70: 661-8 (2013)


Article DOI: 10.1016/j.ejmech.2013.10.040
BindingDB Entry DOI: 10.7270/Q21837Z8
More data for this
Ligand-Target Pair
Kallikrein 7


(Homo sapiens)
BDBM50444604
PNG
(CHEMBL3099870)
Show SMILES COc1cc(\C=C(\C#N)C(=O)Nc2ccc(O)cc2)ccc1O
Show InChI InChI=1S/C17H14N2O4/c1-23-16-9-11(2-7-15(16)21)8-12(10-18)17(22)19-13-3-5-14(20)6-4-13/h2-9,20-21H,1H3,(H,19,22)/b12-8-
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7.00E+4n/an/an/an/an/an/an/an/a



Universit£ Pierre et Marie Curie

Curated by ChEMBL


Assay Description
Mixed-type inhibition of human kallikrein7 using Suc-Leu-Leu-Val-Tyr-AMC as substrate assessed as enzyme-inhibitor complex after 15 to 60 mins by Lin...


Eur J Med Chem 70: 661-8 (2013)


Article DOI: 10.1016/j.ejmech.2013.10.040
BindingDB Entry DOI: 10.7270/Q21837Z8
More data for this
Ligand-Target Pair
Kallikrein 7


(Homo sapiens)
BDBM50355087
PNG
(CHEMBL1833982)
Show SMILES COc1cc(O)c2c(O)c3c(cc(C)oc3=O)c(OC)c2c1
Show InChI InChI=1S/C16H14O6/c1-7-4-9-13(16(19)22-7)14(18)12-10(15(9)21-3)5-8(20-2)6-11(12)17/h4-6,17-18H,1-3H3
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7.07E+4n/an/an/an/an/an/an/an/a



Universidade Federal do Tri£ngulo Mineiro

Curated by ChEMBL


Assay Description
Inhibition of human kallikrein 7 using Abz-KLYSSKQ-EDDnp as substrate by Lineweaver-Burk plot analysis


Bioorg Med Chem Lett 21: 6112-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.08.044
BindingDB Entry DOI: 10.7270/Q24M94ZP
More data for this
Ligand-Target Pair
Kallikrein 7


(Homo sapiens)
BDBM50444602
PNG
(CHEMBL3099874)
Show SMILES COc1ccc(NC(=O)C(=C/c2ccc(O)c(OC)c2)\C#N)cc1
Show InChI InChI=1S/C18H16N2O4/c1-23-15-6-4-14(5-7-15)20-18(22)13(11-19)9-12-3-8-16(21)17(10-12)24-2/h3-10,21H,1-2H3,(H,20,22)/b13-9-
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7.20E+4n/an/an/an/an/an/an/an/a



Universit£ Pierre et Marie Curie

Curated by ChEMBL


Assay Description
Mixed-type inhibition of human kallikrein7 using Suc-Leu-Leu-Val-Tyr-AMC as substrate assessed as enzyme-inhibitor complex after 15 to 60 mins by Lin...


Eur J Med Chem 70: 661-8 (2013)


Article DOI: 10.1016/j.ejmech.2013.10.040
BindingDB Entry DOI: 10.7270/Q21837Z8
More data for this
Ligand-Target Pair
Kallikrein 7


(Homo sapiens)
BDBM50444603
PNG
(CHEMBL3099871)
Show SMILES CCOc1cc(\C=C(\C#N)C(=O)Nc2ccc(O)cc2)ccc1O
Show InChI InChI=1S/C18H16N2O4/c1-2-24-17-10-12(3-8-16(17)22)9-13(11-19)18(23)20-14-4-6-15(21)7-5-14/h3-10,21-22H,2H2,1H3,(H,20,23)/b13-9-
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7.50E+4n/an/an/an/an/an/an/an/a



Universit£ Pierre et Marie Curie

Curated by ChEMBL


Assay Description
Mixed-type inhibition of human kallikrein7 using Suc-Leu-Leu-Val-Tyr-AMC as substrate assessed as enzyme-inhibitor complex after 15 to 60 mins by Lin...


Eur J Med Chem 70: 661-8 (2013)


Article DOI: 10.1016/j.ejmech.2013.10.040
BindingDB Entry DOI: 10.7270/Q21837Z8
More data for this
Ligand-Target Pair
Kallikrein 7


(Homo sapiens)
BDBM50391077
PNG
(CHEMBL2087345)
Show SMILES O=C(N[C@@H]1CO[C@@H]2[C@@H](CO[C@H]12)OCc1ccccc1)C(\NC(=O)c1ccccc1)=C\c1cccnc1
Show InChI InChI=1S/C28H27N3O5/c32-27(21-11-5-2-6-12-21)30-22(14-20-10-7-13-29-15-20)28(33)31-23-17-35-26-24(18-36-25(23)26)34-16-19-8-3-1-4-9-19/h1-15,23-26H,16-18H2,(H,30,32)(H,31,33)/b22-14-/t23-,24-,25-,26-/m1/s1
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7.51E+4n/an/an/an/an/an/an/an/a



Universidade Federal do Tri£ngulo Mineiro

Curated by ChEMBL


Assay Description
Competitive inhibition of recombinant human KLK7 expressed in insect cell/baculovirus using Abz-KLYSSKQ-EDDnp as substrate by Dixon plot analysis


Bioorg Med Chem Lett 22: 6072-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.047
BindingDB Entry DOI: 10.7270/Q2SF2X8R
More data for this
Ligand-Target Pair
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