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Compile Data Set for Download or QSAR

Found 1793 hits Enz. Inhib. hit(s) with Target = 'Macrophage colony-stimulating factor 1 receptor'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM50381703
PNG
(CHEMBL1970317)
Show SMILES Cn1cc(cn1)-c1cnc(N)c2c(csc12)-c1ccc(NC(=O)Nc2cccc(F)c2)cc1
Show InChI InChI=1S/C24H19FN6OS/c1-31-12-15(10-28-31)19-11-27-23(26)21-20(13-33-22(19)21)14-5-7-17(8-6-14)29-24(32)30-18-4-2-3-16(25)9-18/h2-13H,1H3,(H2,26,27)(H2,29,30,32)
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2n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of CSF1R


ACS Med Chem Lett 3: 383-386 (2012)


Article DOI: 10.1021/ml300012r
BindingDB Entry DOI: 10.7270/Q2B56KTH
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM50381719
PNG
(CHEMBL2022856)
Show SMILES C[C@@H](O)Cn1cc(cn1)-c1cnc(N)c2c(csc12)-c1ccc(NC(=O)Nc2cccc(F)c2)cc1
Show InChI InChI=1S/C26H23FN6O2S/c1-15(34)12-33-13-17(10-30-33)21-11-29-25(28)23-22(14-36-24(21)23)16-5-7-19(8-6-16)31-26(35)32-20-4-2-3-18(27)9-20/h2-11,13-15,34H,12H2,1H3,(H2,28,29)(H2,31,32,35)/t15-/m1/s1
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3.20n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of CSF1R


ACS Med Chem Lett 3: 383-386 (2012)


Article DOI: 10.1021/ml300012r
BindingDB Entry DOI: 10.7270/Q2B56KTH
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM50381716
PNG
(ABT-348 | ILORASERTIB | US8722890, 1 | US8722890, ...)
Show SMILES Nc1ncc(-c2cnn(CCO)c2)c2scc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12
Show InChI InChI=1S/C25H21FN6O2S/c26-17-2-1-3-19(10-17)31-25(34)30-18-6-4-15(5-7-18)21-14-35-23-20(12-28-24(27)22(21)23)16-11-29-32(13-16)8-9-33/h1-7,10-14,33H,8-9H2,(H2,27,28)(H2,30,31,34)
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3.20n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of CSF1R


ACS Med Chem Lett 3: 383-386 (2012)


Article DOI: 10.1021/ml300012r
BindingDB Entry DOI: 10.7270/Q2B56KTH
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM50388873
PNG
(CHEMBL1964441)
Show SMILES CNCC#Cc1cnc(N)c2c(csc12)-c1ccc(NC(=O)Nc2cccc(C)c2)cc1
Show InChI InChI=1S/C25H23N5OS/c1-16-5-3-7-20(13-16)30-25(31)29-19-10-8-17(9-11-19)21-15-32-23-18(6-4-12-27-2)14-28-24(26)22(21)23/h3,5,7-11,13-15,27H,12H2,1-2H3,(H2,26,28)(H2,29,30,31)
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5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of CSF1R


ACS Med Chem Lett 3: 383-386 (2012)


Article DOI: 10.1021/ml300012r
BindingDB Entry DOI: 10.7270/Q2B56KTH
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM50388874
PNG
(CHEMBL1967720)
Show SMILES CC(C)(C(N)=O)n1cc(cn1)-c1cnc(N)c2c(csc12)-c1ccc(NC(=O)Nc2cccc(F)c2)cc1
Show InChI InChI=1S/C27H24FN7O2S/c1-27(2,25(30)36)35-13-16(11-32-35)20-12-31-24(29)22-21(14-38-23(20)22)15-6-8-18(9-7-15)33-26(37)34-19-5-3-4-17(28)10-19/h3-14H,1-2H3,(H2,29,31)(H2,30,36)(H2,33,34,37)
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5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of CSF1R


ACS Med Chem Lett 3: 383-386 (2012)


Article DOI: 10.1021/ml300012r
BindingDB Entry DOI: 10.7270/Q2B56KTH
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM50388880
PNG
(CHEMBL1979577)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2csc3c(cnc(N)c23)C#CC(C)(C)N)c1
Show InChI InChI=1S/C26H25N5OS/c1-16-5-4-6-20(13-16)31-25(32)30-19-9-7-17(8-10-19)21-15-33-23-18(11-12-26(2,3)28)14-29-24(27)22(21)23/h4-10,13-15H,28H2,1-3H3,(H2,27,29)(H2,30,31,32)
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7.90n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of CSF1R


ACS Med Chem Lett 3: 383-386 (2012)


Article DOI: 10.1021/ml300012r
BindingDB Entry DOI: 10.7270/Q2B56KTH
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM50020310
PNG
(CHEMBL3288854)
Show SMILES CN1CCN(CCC(=O)Nc2c(C)[nH]c(\C=C3/C(=O)Nc4ccc(F)cc34)c2C)CC1
Show InChI InChI=1S/C23H28FN5O2/c1-14-20(13-18-17-12-16(24)4-5-19(17)26-23(18)31)25-15(2)22(14)27-21(30)6-7-29-10-8-28(3)9-11-29/h4-5,12-13,25H,6-11H2,1-3H3,(H,26,31)(H,27,30)/b18-13-
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230n/an/an/an/an/an/an/an/a



Qilu Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Binding affinity to FMS (unknown origin)


Eur J Med Chem 82: 139-51 (2014)


Article DOI: 10.1016/j.ejmech.2014.05.051
BindingDB Entry DOI: 10.7270/Q2F1918D
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM50402020
PNG
(CHEMBL2205426)
Show SMILES CC(C)(C)Nc1c(Nc2ccnc(Nc3ccc(cc3)-c3ccncc3)n2)c(=O)c1=O
Show InChI InChI=1S/C23H22N6O2/c1-23(2,3)29-19-18(20(30)21(19)31)27-17-10-13-25-22(28-17)26-16-6-4-14(5-7-16)15-8-11-24-12-9-15/h4-13,29H,1-3H3,(H2,25,26,27,28)
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2.10E+3n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of recombinant CSF1R after 1 hr by scintillation counter analysis in presence of gamma-[33P]ATP


Bioorg Med Chem Lett 22: 7615-22 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.009
BindingDB Entry DOI: 10.7270/Q2XK8GQ3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM27912
PNG
(8-(4-ethylphenyl)-N-methoxy-2-{[4-(1-methylpiperid...)
Show SMILES CCc1ccc(cc1)-n1cc(C(=O)NOC)c(=O)c2cnc(Nc3ccc(cc3)C3CCN(C)CC3)nc12
Show InChI InChI=1S/C29H32N6O3/c1-4-19-5-11-23(12-6-19)35-18-25(28(37)33-38-3)26(36)24-17-30-29(32-27(24)35)31-22-9-7-20(8-10-22)21-13-15-34(2)16-14-21/h5-12,17-18,21H,4,13-16H2,1-3H3,(H,33,37)(H,30,31,32)
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n/an/a 0.300n/an/an/an/a7.522



Johnson & Johnson Pharmaceutical



Assay Description
FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...


J Med Chem 52: 1081-99 (2009)


Article DOI: 10.1021/jm801406h
BindingDB Entry DOI: 10.7270/Q21834T7
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM50377072
PNG
(CHEMBL438533)
Show SMILES CC1CCN(CC1)c1cc(ccc1NC(=O)c1ccc(o1)C#N)C1CCNCC1
Show InChI InChI=1S/C23H28N4O2/c1-16-8-12-27(13-9-16)21-14-18(17-6-10-25-11-7-17)2-4-20(21)26-23(28)22-5-3-19(15-24)29-22/h2-5,14,16-17,25H,6-13H2,1H3,(H,26,28)
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n/an/a 0.300n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of FMS mediated phosphorylation using SYEGNSYTFIDPTQ as substrate after 80 mins by fluorescence polarization


J Med Chem 54: 7860-83 (2011)


Article DOI: 10.1021/jm200900q
BindingDB Entry DOI: 10.7270/Q2VD70JB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM50377072
PNG
(CHEMBL438533)
Show SMILES CC1CCN(CC1)c1cc(ccc1NC(=O)c1ccc(o1)C#N)C1CCNCC1
Show InChI InChI=1S/C23H28N4O2/c1-16-8-12-27(13-9-16)21-14-18(17-6-10-25-11-7-17)2-4-20(21)26-23(28)22-5-3-19(15-24)29-22/h2-5,14,16-17,25H,6-13H2,1H3,(H,26,28)
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n/an/a 0.300n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of FMS


Bioorg Med Chem Lett 18: 3632-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.059
BindingDB Entry DOI: 10.7270/Q2FN173T
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM50321368
PNG
(4-cyano-N-(4-(1,3-dimethyl-2-oxohexahydropyrimidin...)
Show SMILES CN1CC(CN(C)C1=O)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1
Show InChI InChI=1S/C25H30N6O2/c1-25(2)9-7-16(8-10-25)20-11-17(18-14-30(3)24(33)31(4)15-18)5-6-21(20)29-23(32)22-27-13-19(12-26)28-22/h5-7,11,13,18H,8-10,14-15H2,1-4H3,(H,27,28)(H,29,32)
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n/an/a 0.300n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human FMS by fluorescence polarization


Bioorg Med Chem Lett 20: 3925-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.013
BindingDB Entry DOI: 10.7270/Q22Z16HG
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM50377071
PNG
(CHEMBL402337)
Show SMILES CC1CCC(=CC1)c1cc(ccc1NC(=O)c1ncc([nH]1)C#N)C1CCNCC1
Show InChI InChI=1S/C23H27N5O/c1-15-2-4-17(5-3-15)20-12-18(16-8-10-25-11-9-16)6-7-21(20)28-23(29)22-26-14-19(13-24)27-22/h4,6-7,12,14-16,25H,2-3,5,8-11H2,1H3,(H,26,27)(H,28,29)
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n/an/a 0.400n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of FMS


Bioorg Med Chem Lett 18: 3632-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.059
BindingDB Entry DOI: 10.7270/Q2FN173T
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM27913
PNG
(8-(3-ethylphenyl)-N-methoxy-2-{[4-(1-methylpiperid...)
Show SMILES CCc1cccc(c1)-n1cc(C(=O)NOC)c(=O)c2cnc(Nc3ccc(cc3)C3CCN(C)CC3)nc12
Show InChI InChI=1S/C29H32N6O3/c1-4-19-6-5-7-23(16-19)35-18-25(28(37)33-38-3)26(36)24-17-30-29(32-27(24)35)31-22-10-8-20(9-11-22)21-12-14-34(2)15-13-21/h5-11,16-18,21H,4,12-15H2,1-3H3,(H,33,37)(H,30,31,32)
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n/an/a 0.400n/an/an/an/a7.522



Johnson & Johnson Pharmaceutical



Assay Description
FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...


J Med Chem 52: 1081-99 (2009)


Article DOI: 10.1021/jm801406h
BindingDB Entry DOI: 10.7270/Q21834T7
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM50321373
PNG
(4-cyano-N-(4-(2-(cyanoimino)-1,3-dimethylhexahydro...)
Show SMILES CN1CC(CN(C)C1=NC#N)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1
Show InChI InChI=1S/C26H30N8O/c1-26(2)9-7-17(8-10-26)21-11-18(19-14-33(3)25(30-16-28)34(4)15-19)5-6-22(21)32-24(35)23-29-13-20(12-27)31-23/h5-7,11,13,19H,8-10,14-15H2,1-4H3,(H,29,31)(H,32,35)
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n/an/a 0.400n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human FMS by fluorescence polarization


Bioorg Med Chem Lett 20: 3925-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.013
BindingDB Entry DOI: 10.7270/Q22Z16HG
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM27909
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-N-methoxy-2-{[4-(1-m...)
Show SMILES CONC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(cc3)C3CCN(C)CC3)ncc2c1=O
Show InChI InChI=1S/C30H32N6O3/c1-35-14-12-21(13-15-35)20-6-9-23(10-7-20)32-30-31-17-25-27(37)26(29(38)34-39-2)18-36(28(25)33-30)24-11-8-19-4-3-5-22(19)16-24/h6-11,16-18,21H,3-5,12-15H2,1-2H3,(H,34,38)(H,31,32,33)
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n/an/a 0.400n/an/an/an/a7.522



Johnson & Johnson Pharmaceutical



Assay Description
FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...


J Med Chem 52: 1081-99 (2009)


Article DOI: 10.1021/jm801406h
BindingDB Entry DOI: 10.7270/Q21834T7
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM27915
PNG
(8-(4,4-dimethylcyclohexyl)-N-methoxy-2-{[4-(1-meth...)
Show SMILES CONC(=O)c1cn(C2CCC(C)(C)CC2)c2nc(Nc3ccc(cc3)C3CCN(C)CC3)ncc2c1=O
Show InChI InChI=1S/C29H38N6O3/c1-29(2)13-9-22(10-14-29)35-18-24(27(37)33-38-4)25(36)23-17-30-28(32-26(23)35)31-21-7-5-19(6-8-21)20-11-15-34(3)16-12-20/h5-8,17-18,20,22H,9-16H2,1-4H3,(H,33,37)(H,30,31,32)
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n/an/a 0.400n/an/an/an/a7.522



Johnson & Johnson Pharmaceutical



Assay Description
FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...


J Med Chem 52: 1081-99 (2009)


Article DOI: 10.1021/jm801406h
BindingDB Entry DOI: 10.7270/Q21834T7
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM98644
PNG
(US8497376, 20)
Show SMILES CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1ncc([nH]1)C#N)C1C[C@@](C)(CO)O[C@@](C)(CO)C1
Show InChI InChI=1S/C27H35N5O4/c1-25(2)9-7-17(8-10-25)22-21(32-24(35)23-29-14-19(13-28)30-23)6-5-20(31-22)18-11-26(3,15-33)36-27(4,12-18)16-34/h5-7,14,18,33-34H,8-12,15-16H2,1-4H3,(H,29,30)(H,32,35)/t18?,26-,27+
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n/an/a 0.410n/an/an/an/a7.5n/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
An autophosphorylation, fluroescence polarization competition immunoassay was used to determine the potency for c-fms inhibition.


US Patent US8497376 (2013)


BindingDB Entry DOI: 10.7270/Q2RN36GW
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM98627
PNG
(US8497376, 8)
Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1nc(c[nH]1)[N+]#[C-])[C@]1(O)C[C@@]2(CO)CC[C@@](CO)(C1)O2
Show InChI InChI=1S/C28H34N4O5/c1-25(2)8-6-18(7-9-25)20-12-19(4-5-21(20)31-24(35)23-30-13-22(29-3)32-23)28(36)14-26(16-33)10-11-27(15-28,17-34)37-26/h4-6,12-13,33-34,36H,7-11,14-17H2,1-2H3,(H,30,32)(H,31,35)/t26-,27+,28+
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n/an/a 0.420n/an/an/an/a7.5n/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
An autophosphorylation, fluroescence polarization competition immunoassay was used to determine the potency for c-fms inhibition.


US Patent US8497376 (2013)


BindingDB Entry DOI: 10.7270/Q2RN36GW
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM238106
PNG
(US9394289, 2)
Show SMILES CN(C)CCOC1(CCOCC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1
Show InChI InChI=1S/C28H37N5O3/c1-27(2)9-7-20(8-10-27)23-17-21(28(11-14-35-15-12-28)36-16-13-33(3)4)5-6-24(23)32-26(34)25-30-19-22(18-29)31-25/h5-7,17,19H,8-16H2,1-4H3,(H,30,31)(H,32,34)
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n/an/a 0.420n/an/an/an/a7.525



Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...


US Patent US9394289 (2016)


BindingDB Entry DOI: 10.7270/Q28K780X
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM98621
PNG
(US8497376, 2)
Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1ncc([nH]1)C#N)[C@]1(O)C[C@]2(CO)O[C@](CO)(C1)C=C2
Show InChI InChI=1S/C28H32N4O5/c1-25(2)7-5-18(6-8-25)21-11-19(3-4-22(21)32-24(35)23-30-13-20(12-29)31-23)28(36)14-26(16-33)9-10-27(15-28,17-34)37-26/h3-5,9-11,13,33-34,36H,6-8,14-17H2,1-2H3,(H,30,31)(H,32,35)/t26-,27+,28+
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n/an/a 0.430n/an/an/an/a7.5n/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
An autophosphorylation, fluroescence polarization competition immunoassay was used to determine the potency for c-fms inhibition.


US Patent US8497376 (2013)


BindingDB Entry DOI: 10.7270/Q2RN36GW
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM119049
PNG
(CHEMBL3086320 | US8674100, 20 | US8674100, 69)
Show SMILES COCCNC(C)(C)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1
Show InChI InChI=1S/C25H33N5O2/c1-24(2)10-8-17(9-11-24)20-14-18(25(3,4)28-12-13-32-5)6-7-21(20)30-23(31)22-27-16-19(15-26)29-22/h6-8,14,16,28H,9-13H2,1-5H3,(H,27,29)(H,30,31)
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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CSF-...


US Patent US8674100 (2014)


BindingDB Entry DOI: 10.7270/Q23777CF
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) or (c-fms)


(Homo sapiens (Human))
BDBM198857
PNG
(BDBM198884 | US9221797, 20)
Show SMILES COCCNC(C)(C)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1
Show InChI InChI=1S/C25H33N5O2/c1-24(2)10-8-17(9-11-24)20-14-18(25(3,4)28-12-13-32-5)6-7-21(20)30-23(31)22-27-16-19(15-26)29-22/h6-8,14,16,28H,9-13H2,1-5H3,(H,27,29)(H,30,31)
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n/an/a 0.440n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...


US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM98624
PNG
(US8497376, 5)
Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1ncc([nH]1)C#N)[C@H]1C[C@@]2(CO)CC[C@@](CO)(C1)O2
Show InChI InChI=1S/C28H34N4O4/c1-26(2)7-5-18(6-8-26)22-11-19(20-12-27(16-33)9-10-28(13-20,17-34)36-27)3-4-23(22)32-25(35)24-30-15-21(14-29)31-24/h3-5,11,15,20,33-34H,6-10,12-13,16-17H2,1-2H3,(H,30,31)(H,32,35)/t20-,27+,28-
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n/an/a 0.470n/an/an/an/a7.5n/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
An autophosphorylation, fluroescence polarization competition immunoassay was used to determine the potency for c-fms inhibition.


US Patent US8497376 (2013)


BindingDB Entry DOI: 10.7270/Q2RN36GW
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM238129
PNG
(US9394289, 25)
Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1nc(c[nH]1)C#N)C1(CO)CCOCC1
Show InChI InChI=1S/C25H30N4O3/c1-24(2)7-5-17(6-8-24)20-13-18(25(16-30)9-11-32-12-10-25)3-4-21(20)29-23(31)22-27-15-19(14-26)28-22/h3-5,13,15,30H,6-12,16H2,1-2H3,(H,27,28)(H,29,31)
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n/an/a 0.490n/an/an/an/a7.525



Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...


US Patent US9394289 (2016)


BindingDB Entry DOI: 10.7270/Q28K780X
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM27906
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-N-methoxy-5-oxo-2-{[...)
Show SMILES CONC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(cc3)C3CCNCC3)ncc2c1=O
Show InChI InChI=1S/C29H30N6O3/c1-38-34-28(37)25-17-35(23-10-7-18-3-2-4-21(18)15-23)27-24(26(25)36)16-31-29(33-27)32-22-8-5-19(6-9-22)20-11-13-30-14-12-20/h5-10,15-17,20,30H,2-4,11-14H2,1H3,(H,34,37)(H,31,32,33)
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n/an/a 0.5n/an/an/an/a7.522



Johnson & Johnson Pharmaceutical



Assay Description
FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...


J Med Chem 52: 1081-99 (2009)


Article DOI: 10.1021/jm801406h
BindingDB Entry DOI: 10.7270/Q21834T7
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM27896
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-N-ethoxy-2-({4-[2-(4...)
Show SMILES CCONC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(CCN4CCN(C)CC4)cc3)ncc2c1=O
Show InChI InChI=1S/C32H37N7O3/c1-3-42-36-31(41)28-21-39(26-12-9-23-5-4-6-24(23)19-26)30-27(29(28)40)20-33-32(35-30)34-25-10-7-22(8-11-25)13-14-38-17-15-37(2)16-18-38/h7-12,19-21H,3-6,13-18H2,1-2H3,(H,36,41)(H,33,34,35)
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Johnson & Johnson Pharmaceutical



Assay Description
FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...


J Med Chem 52: 1081-99 (2009)


Article DOI: 10.1021/jm801406h
BindingDB Entry DOI: 10.7270/Q21834T7
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM50321367
PNG
(4-cyano-N-(2-cyclohexenyl-4-(1,3-dimethyl-2-oxohex...)
Show SMILES CN1CC(CN(C)C1=O)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C23H26N6O2/c1-28-13-17(14-29(2)23(28)31)16-8-9-20(19(10-16)15-6-4-3-5-7-15)27-22(30)21-25-12-18(11-24)26-21/h6,8-10,12,17H,3-5,7,13-14H2,1-2H3,(H,25,26)(H,27,30)
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n/an/a 0.5n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human FMS by fluorescence polarization


Bioorg Med Chem Lett 20: 3925-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.013
BindingDB Entry DOI: 10.7270/Q22Z16HG
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM50321365
PNG
(4-cyano-N-(2-cyclohexenyl-4-(1-methyl-2,6-dioxopip...)
Show SMILES CN1C(=O)CC(CC1=O)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C23H23N5O3/c1-28-20(29)10-16(11-21(28)30)15-7-8-19(18(9-15)14-5-3-2-4-6-14)27-23(31)22-25-13-17(12-24)26-22/h5,7-9,13,16H,2-4,6,10-11H2,1H3,(H,25,26)(H,27,31)
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human FMS by fluorescence polarization


Bioorg Med Chem Lett 20: 3925-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.013
BindingDB Entry DOI: 10.7270/Q22Z16HG
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM27897
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-2-({4-[2-(4-methylpi...)
Show SMILES CC(C)ONC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(CCN4CCN(C)CC4)cc3)ncc2c1=O
Show InChI InChI=1S/C33H39N7O3/c1-22(2)43-37-32(42)29-21-40(27-12-9-24-5-4-6-25(24)19-27)31-28(30(29)41)20-34-33(36-31)35-26-10-7-23(8-11-26)13-14-39-17-15-38(3)16-18-39/h7-12,19-22H,4-6,13-18H2,1-3H3,(H,37,42)(H,34,35,36)
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Johnson & Johnson Pharmaceutical



Assay Description
FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...


J Med Chem 52: 1081-99 (2009)


Article DOI: 10.1021/jm801406h
BindingDB Entry DOI: 10.7270/Q21834T7
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM238109
PNG
(US9394289, 5)
Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1ncc([nH]1)C#N)C1(N)CCOCC1
Show InChI InChI=1S/C24H29N5O2/c1-23(2)7-5-16(6-8-23)19-13-17(24(26)9-11-31-12-10-24)3-4-20(19)29-22(30)21-27-15-18(14-25)28-21/h3-5,13,15H,6-12,26H2,1-2H3,(H,27,28)(H,29,30)
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n/an/a 0.5n/an/an/an/a7.525



Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...


US Patent US9394289 (2016)


BindingDB Entry DOI: 10.7270/Q28K780X
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM119049
PNG
(CHEMBL3086320 | US8674100, 20 | US8674100, 69)
Show SMILES COCCNC(C)(C)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1
Show InChI InChI=1S/C25H33N5O2/c1-24(2)10-8-17(9-11-24)20-14-18(25(3,4)28-12-13-32-5)6-7-21(20)30-23(31)22-27-16-19(15-26)29-22/h6-8,14,16,28H,9-13H2,1-5H3,(H,27,29)(H,30,31)
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n/an/a 0.510n/an/an/an/a7.5n/a



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CSF-...


US Patent US8674100 (2014)


BindingDB Entry DOI: 10.7270/Q23777CF
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) or (c-fms)


(Homo sapiens (Human))
BDBM198857
PNG
(BDBM198884 | US9221797, 20)
Show SMILES COCCNC(C)(C)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1
Show InChI InChI=1S/C25H33N5O2/c1-24(2)10-8-17(9-11-24)20-14-18(25(3,4)28-12-13-32-5)6-7-21(20)30-23(31)22-27-16-19(15-26)29-22/h6-8,14,16,28H,9-13H2,1-5H3,(H,27,29)(H,30,31)
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n/an/a 0.510n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...


US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM238121
PNG
(US9394289, 17)
Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1nc(c[nH]1)C#N)C1(CCOCC1)C(O)=O
Show InChI InChI=1S/C25H28N4O4/c1-24(2)7-5-16(6-8-24)19-13-17(25(23(31)32)9-11-33-12-10-25)3-4-20(19)29-22(30)21-27-15-18(14-26)28-21/h3-5,13,15H,6-12H2,1-2H3,(H,27,28)(H,29,30)(H,31,32)
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Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...


US Patent US9394289 (2016)


BindingDB Entry DOI: 10.7270/Q28K780X
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM50233716
PNG
(5-cyano-N-(4-(4-(2-hydroxyethyl)piperazin-1-yl)-2-...)
Show SMILES CC1CCN(CC1)c1cc(ccc1NC(=O)c1ccc(o1)C#N)N1CCN(CCO)CC1
Show InChI InChI=1S/C24H31N5O3/c1-18-6-8-29(9-7-18)22-16-19(28-12-10-27(11-13-28)14-15-30)2-4-21(22)26-24(31)23-5-3-20(17-25)32-23/h2-5,16,18,30H,6-15H2,1H3,(H,26,31)
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n/an/a 0.600n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic FMS expressed in Sf9-baculovirus system after 80 mins by fluorescence polarization


Bioorg Med Chem Lett 18: 1642-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.059
BindingDB Entry DOI: 10.7270/Q2FB52PS
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM119032
PNG
(US8674100, 45)
Show SMILES CC(C)(N1CCCC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1
Show InChI InChI=1S/C26H33N5O/c1-25(2)11-9-18(10-12-25)21-15-19(26(3,4)31-13-5-6-14-31)7-8-22(21)30-24(32)23-28-17-20(16-27)29-23/h7-9,15,17H,5-6,10-14H2,1-4H3,(H,28,29)(H,30,32)
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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CSF-...


US Patent US8674100 (2014)


BindingDB Entry DOI: 10.7270/Q23777CF
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) or (c-fms)


(Homo sapiens (Human))
BDBM198873
PNG
(US9221797, 45)
Show SMILES CC1CCCC(=C1C)c1cc(ccc1NC(=O)c1ncc([nH]1)C#N)C(C)(C)N1CCCC1
Show InChI InChI=1S/C26H33N5O/c1-17-8-7-9-21(18(17)2)22-14-19(26(3,4)31-12-5-6-13-31)10-11-23(22)30-25(32)24-28-16-20(15-27)29-24/h10-11,14,16-17H,5-9,12-13H2,1-4H3,(H,28,29)(H,30,32)
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Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...


US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM119049
PNG
(CHEMBL3086320 | US8674100, 20 | US8674100, 69)
Show SMILES COCCNC(C)(C)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1
Show InChI InChI=1S/C25H33N5O2/c1-24(2)10-8-17(9-11-24)20-14-18(25(3,4)28-12-13-32-5)6-7-21(20)30-23(31)22-27-16-19(15-26)29-22/h6-8,14,16,28H,9-13H2,1-5H3,(H,27,29)(H,30,31)
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n/an/a 0.600n/an/an/an/an/an/a



Janssen Pharmaceutical Research& Development LLC

Curated by ChEMBL


Assay Description
Inhibition of FMS (unknown origin)


Bioorg Med Chem Lett 23: 6363-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.061
BindingDB Entry DOI: 10.7270/Q2MP54RH
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM50443154
PNG
(CHEMBL3085973 | US8674100, 147)
Show SMILES COCCNCC(C)(C)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1
Show InChI InChI=1S/C26H35N5O2/c1-25(2)10-8-18(9-11-25)21-14-19(26(3,4)17-28-12-13-33-5)6-7-22(21)31-24(32)23-29-16-20(15-27)30-23/h6-8,14,16,28H,9-13,17H2,1-5H3,(H,29,30)(H,31,32)
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n/an/a 0.600n/an/an/an/an/an/a



Janssen Pharmaceutical Research& Development LLC

Curated by ChEMBL


Assay Description
Inhibition of FMS (unknown origin)


Bioorg Med Chem Lett 23: 6363-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.061
BindingDB Entry DOI: 10.7270/Q2MP54RH
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM50393560
PNG
(CHEMBL2158300 | US8697716, 48)
Show SMILES CC(C)(N)CC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C27H34N6O2/c1-27(2,29)15-24(34)33-12-10-18(11-13-33)20-8-9-23(22(14-20)19-6-4-3-5-7-19)32-26(35)25-30-17-21(16-28)31-25/h6,8-9,14,17-18H,3-5,7,10-13,15,29H2,1-2H3,(H,30,31)(H,32,35)
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n/an/a 0.620n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of FMS mediated phosphorylation using SYEGNSYTFIDPTQ as substrate after 80 mins by fluorescence polarization


J Med Chem 54: 7860-83 (2011)


Article DOI: 10.1021/jm200900q
BindingDB Entry DOI: 10.7270/Q2VD70JB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM50393549
PNG
(CHEMBL2158289)
Show SMILES CN(CCO)CC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C27H34N6O3/c1-32(13-14-34)18-25(35)33-11-9-19(10-12-33)21-7-8-24(23(15-21)20-5-3-2-4-6-20)31-27(36)26-29-17-22(16-28)30-26/h5,7-8,15,17,19,34H,2-4,6,9-14,18H2,1H3,(H,29,30)(H,31,36)
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n/an/a 0.640n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of FMS-mediated proliferation in CSF1-stimulated bone marrow-derived mouse macrophages assessed as inhibition of incorporation of bromodeo...


J Med Chem 54: 7860-83 (2011)


Article DOI: 10.1021/jm200900q
BindingDB Entry DOI: 10.7270/Q2VD70JB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM50443154
PNG
(CHEMBL3085973 | US8674100, 147)
Show SMILES COCCNCC(C)(C)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1
Show InChI InChI=1S/C26H35N5O2/c1-25(2)10-8-18(9-11-25)21-14-19(26(3,4)17-28-12-13-33-5)6-7-22(21)31-24(32)23-29-16-20(15-27)30-23/h6-8,14,16,28H,9-13,17H2,1-5H3,(H,29,30)(H,31,32)
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n/an/a 0.640n/an/an/an/a7.5n/a



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CSF-...


US Patent US8674100 (2014)


BindingDB Entry DOI: 10.7270/Q23777CF
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) or (c-fms)


(Homo sapiens (Human))
BDBM198904
PNG
(US9221797, 147)
Show SMILES COCCNCC(C)(C)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1
Show InChI InChI=1S/C26H35N5O2/c1-25(2)10-8-18(9-11-25)21-14-19(26(3,4)17-28-12-13-33-5)6-7-22(21)31-24(32)23-29-16-20(15-27)30-23/h6-8,14,16,28H,9-13,17H2,1-5H3,(H,29,30)(H,31,32)
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US Patent
n/an/a 0.640n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...


US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM98622
PNG
(US8497376, 3)
Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1ncc([nH]1)C#N)C1=C[C@]2(CO)O[C@](CO)(C1)C=C2
Show InChI InChI=1S/C28H30N4O4/c1-26(2)7-5-18(6-8-26)22-11-19(20-12-27(16-33)9-10-28(13-20,17-34)36-27)3-4-23(22)32-25(35)24-30-15-21(14-29)31-24/h3-5,9-12,15,33-34H,6-8,13,16-17H2,1-2H3,(H,30,31)(H,32,35)/t27-,28+/m1/s1
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n/an/a 0.650n/an/an/an/a7.5n/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
An autophosphorylation, fluroescence polarization competition immunoassay was used to determine the potency for c-fms inhibition.


US Patent US8497376 (2013)


BindingDB Entry DOI: 10.7270/Q2RN36GW
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM238225
PNG
(US9403804, 2)
Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1ncc([nH]1)C#N)[C@@]1(O)CC[C@@H](CC1)C(O)=O
Show InChI InChI=1S/C26H30N4O4/c1-25(2)9-5-16(6-10-25)20-13-18(26(34)11-7-17(8-12-26)24(32)33)3-4-21(20)30-23(31)22-28-15-19(14-27)29-22/h3-5,13,15,17,34H,6-12H2,1-2H3,(H,28,29)(H,30,31)(H,32,33)/t17-,26+
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n/an/a 0.650n/an/an/an/a7.525



Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...


US Patent US9403804 (2016)


BindingDB Entry DOI: 10.7270/Q23T9G3C
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM98648
PNG
(US8497376, 27)
Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1ncc([nH]1)C#N)[C@@]1(O)CC2O[C@@H](C1)C=C2
Show InChI InChI=1S/C26H28N4O3/c1-25(2)9-7-16(8-10-25)21-11-17(26(32)12-19-4-5-20(13-26)33-19)3-6-22(21)30-24(31)23-28-15-18(14-27)29-23/h3-7,11,15,19-20,32H,8-10,12-13H2,1-2H3,(H,28,29)(H,30,31)/t19-,20?,26+/m1/s1
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n/an/a 0.660n/an/an/an/a7.5n/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
An autophosphorylation, fluroescence polarization competition immunoassay was used to determine the potency for c-fms inhibition.


US Patent US8497376 (2013)


BindingDB Entry DOI: 10.7270/Q2RN36GW
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM98631
PNG
(US8497376, 12)
Show SMILES C[C@@]12C[C@](O)(C[C@@](C)(O1)[C@@H](O)[C@H]2O)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1
Show InChI InChI=1S/C28H34N4O5/c1-25(2)9-7-16(8-10-25)19-11-17(5-6-20(19)32-24(35)23-30-13-18(12-29)31-23)28(36)14-26(3)21(33)22(34)27(4,15-28)37-26/h5-7,11,13,21-22,33-34,36H,8-10,14-15H2,1-4H3,(H,30,31)(H,32,35)/t21-,22+,26+,27-,28+
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n/an/a 0.660n/an/an/an/a7.5n/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
An autophosphorylation, fluroescence polarization competition immunoassay was used to determine the potency for c-fms inhibition.


US Patent US8497376 (2013)


BindingDB Entry DOI: 10.7270/Q2RN36GW
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM238111
PNG
(US9394289, 7)
Show SMILES CN(C)C1(CCOCC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1
Show InChI InChI=1S/C26H33N5O2/c1-25(2)9-7-18(8-10-25)21-15-19(26(31(3)4)11-13-33-14-12-26)5-6-22(21)30-24(32)23-28-17-20(16-27)29-23/h5-7,15,17H,8-14H2,1-4H3,(H,28,29)(H,30,32)
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n/an/a 0.670n/an/an/an/a7.525



Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...


US Patent US9394289 (2016)


BindingDB Entry DOI: 10.7270/Q28K780X
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM238120
PNG
(US9394289, 16)
Show SMILES COC(=O)C1(CCOCC1)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1
Show InChI InChI=1S/C26H30N4O4/c1-25(2)8-6-17(7-9-25)20-14-18(26(24(32)33-3)10-12-34-13-11-26)4-5-21(20)30-23(31)22-28-16-19(15-27)29-22/h4-6,14,16H,7-13H2,1-3H3,(H,28,29)(H,30,31)
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n/an/a 0.670n/an/an/an/a7.525



Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...


US Patent US9394289 (2016)


BindingDB Entry DOI: 10.7270/Q28K780X
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM50443167
PNG
(CHEMBL3085977 | US8674100, 76)
Show SMILES CC(=O)NCCNC(C)(C)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1
Show InChI InChI=1S/C26H34N6O2/c1-17(33)28-12-13-30-26(4,5)19-6-7-22(32-24(34)23-29-16-20(15-27)31-23)21(14-19)18-8-10-25(2,3)11-9-18/h6-8,14,16,30H,9-13H2,1-5H3,(H,28,33)(H,29,31)(H,32,34)
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n/an/a 0.680n/an/an/an/a7.5n/a



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CSF-...


US Patent US8674100 (2014)


BindingDB Entry DOI: 10.7270/Q23777CF
More data for this
Ligand-Target Pair
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