BindingDB PrimarySearch

Found 403 hits Enz. Inhib. hit(s) with Target = 'Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit (Rattus norvegicus (Rat))	BDBM50049757 (()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...) Show SMILES Clc1ccc(cn1)C1CC2CCC1N2 Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	0.150	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
SRI International Curated by ChEMBL					Assay Description Displacement of [3H]epibatidine from rat alpha3beta4 nAChR expressed in HEK292 cells after 3 hrs				J Med Chem 53: 8187-91 (2010) Article DOI: 10.1021/jm1006148 BindingDB Entry DOI: 10.7270/Q2MC9080
SRI International Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit (HUMAN)	BDBM50049757 (()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...) Show SMILES Clc1ccc(cn1)C1CC2CCC1N2 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	0.457	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Wollongong Curated by ChEMBL					Assay Description Binding affinity of the compound was determined against Nicotinic acetylcholine receptor using [3H]-(-)-nicotine radioligand				Bioorg Med Chem Lett 14: 271-3 (2003) Article DOI: 10.1016/j.bmcl.2003.09.081 BindingDB Entry DOI: 10.7270/Q2MC8ZD0
University of Wollongong Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit (Rattus norvegicus (Rat))	BDBM50049757 (()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...) Show SMILES Clc1ccc(cn1)C1CC2CCC1N2 Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	0.480	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Georgetown University School of Medicine Curated by ChEMBL					Assay Description Binding affinity towards rat Nicotinic acetylcholine receptor alpha4-beta4 expressed in HEK293 cells using [3H]EB as radioligand				Bioorg Med Chem Lett 14: 1845-8 (2004) Article DOI: 10.1016/j.bmcl.2003.09.105 BindingDB Entry DOI: 10.7270/Q2TB17G2
Georgetown University School of Medicine Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit (Rattus norvegicus (Rat))	BDBM50049757 (()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...) Show SMILES Clc1ccc(cn1)C1CC2CCC1N2 Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	0.565	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago Curated by ChEMBL					Assay Description Binding affinity towards Nicotinic acetylcholine receptor alpha4-beta4 using [3H]epibatidine				Bioorg Med Chem Lett 14: 1855-8 (2004) Article DOI: 10.1016/j.bmcl.2003.10.071 BindingDB Entry DOI: 10.7270/Q269753N
University of Illinois at Chicago Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit (Rattus norvegicus (Rat))	BDBM50049757 (()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...) Show SMILES Clc1ccc(cn1)C1CC2CCC1N2 Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	0.570	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago Curated by ChEMBL					Assay Description Inhibition of [3H]epibatidine binding to rat Nicotinic acetylcholine receptor alpha3-beta4				J Med Chem 48: 1721-4 (2005) Article DOI: 10.1021/jm0492406 BindingDB Entry DOI: 10.7270/Q2BZ65JW
University of Illinois at Chicago Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit (Rattus norvegicus (Rat))	BDBM50049757 (()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...) Show SMILES Clc1ccc(cn1)C1CC2CCC1N2 Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	0.830	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Georgetown University School of Medicine Curated by ChEMBL					Assay Description Binding affinity towards rat Nicotinic acetylcholine receptor alpha3-beta2 expressed in HEK293 cells using [3H]EB as radioligand				Bioorg Med Chem Lett 14: 1845-8 (2004) Article DOI: 10.1016/j.bmcl.2003.09.105 BindingDB Entry DOI: 10.7270/Q2TB17G2
Georgetown University School of Medicine Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit (Rattus norvegicus (Rat))	BDBM50162982 (3-Hex-1-ynyl-5-((S)-1-methyl-pyrrolidin-2-ylmethox...) Show SMILES CCCCC#Cc1cncc(OC[C@@H]2CCCN2C)c1 Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago Curated by ChEMBL					Assay Description Inhibition of [3H]epibatidine binding to rat Nicotinic acetylcholine receptor alpha3-beta4				J Med Chem 48: 1721-4 (2005) Article DOI: 10.1021/jm0492406 BindingDB Entry DOI: 10.7270/Q2BZ65JW
University of Illinois at Chicago Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit (HUMAN)	BDBM50140291 (CHEMBL3758455) Show SMILES Ic1cccc(c1)C1=NCCCC1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	4.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Milano Curated by ChEMBL					Assay Description Displacement of [3H]-epibatidine from human alpha3beta4 nACh receptor expressed in HEK293 cells preincubated for 5 mins followed by radioligand addit...				Eur J Med Chem 108: 392-405 (2016) Article DOI: 10.1016/j.ejmech.2015.11.045 BindingDB Entry DOI: 10.7270/Q2ZS2ZCH
Universit£ degli Studi di Milano Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit (Rattus norvegicus (Rat))	BDBM50049756 (3-((S)-1-Methyl-pyrrolidin-2-ylmethoxy)-pyridine \|...) Show SMILES CN1CCC[C@H]1COc1cccnc1 Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	14	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago Curated by ChEMBL					Assay Description Inhibition of [3H]epibatidine binding to rat Nicotinic acetylcholine receptor alpha3-beta4				J Med Chem 48: 1721-4 (2005) Article DOI: 10.1021/jm0492406 BindingDB Entry DOI: 10.7270/Q2BZ65JW
University of Illinois at Chicago Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit (Rattus norvegicus (Rat))	BDBM50162988 (3-[5-((S)-1-Methyl-pyrrolidin-2-ylmethoxy)-pyridin...) Show SMILES CN1CCC[C@H]1COc1cncc(c1)C#CCO Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	23	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago Curated by ChEMBL					Assay Description Inhibition of [3H]epibatidine binding to rat Nicotinic acetylcholine receptor alpha3-beta4				J Med Chem 48: 1721-4 (2005) Article DOI: 10.1021/jm0492406 BindingDB Entry DOI: 10.7270/Q2BZ65JW
University of Illinois at Chicago Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit (HUMAN)	BDBM50203716 (CHEMBL3982273) Show SMILES CN1CCC[C@H]1COc1cc(O)cc(c1)-c1ccc(O)cc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Milano Curated by ChEMBL					Assay Description Displacement of [3H]-epibatine from human alpha3beta4-nACHR expressed in HEK243 cell membranes preincubated for 5 mins followed by overnight incubati...				Bioorg Med Chem Lett 26: 5613-5617 (2016) Article DOI: 10.1016/j.bmcl.2016.10.078 BindingDB Entry DOI: 10.7270/Q2RJ4MFR
Universit£ degli Studi di Milano Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit (HUMAN)	BDBM50140289 (CHEMBL3759225) Show SMILES Brc1cccc(c1)C1=NCCCC1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Milano Curated by ChEMBL					Assay Description Displacement of [3H]-epibatidine from human alpha3beta4 nACh receptor expressed in HEK293 cells preincubated for 5 mins followed by radioligand addit...				Eur J Med Chem 108: 392-405 (2016) Article DOI: 10.1016/j.ejmech.2015.11.045 BindingDB Entry DOI: 10.7270/Q2ZS2ZCH
Universit£ degli Studi di Milano Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit (Rattus norvegicus (Rat))	BDBM50162983 (6-[5-(7-Aza-bicyclo[2.2.1]hept-2-yl)-pyridin-3-yl]...) Show SMILES OCCCCC#Cc1cncc(c1)C1CC2CCC1N2 Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	31	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago Curated by ChEMBL					Assay Description Inhibition of [3H]epibatidine binding to rat Nicotinic acetylcholine receptor alpha3-beta4				J Med Chem 48: 1721-4 (2005) Article DOI: 10.1021/jm0492406 BindingDB Entry DOI: 10.7270/Q2BZ65JW
University of Illinois at Chicago Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit (Rattus norvegicus (Rat))	BDBM50452056 (CHEMBL417586) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	48	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago Curated by ChEMBL					Assay Description Binding affinity towards nicotinic acetylcholine receptor alpha2-beta2 using [3H]epibatidine				Bioorg Med Chem Lett 14: 1855-8 (2004) Article DOI: 10.1016/j.bmcl.2003.10.071 BindingDB Entry DOI: 10.7270/Q269753N
University of Illinois at Chicago Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit (HUMAN)	BDBM50140303 (CHEMBL3759863) Show SMILES Fc1cc(Br)cc(c1)C1=NCCCC1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	48	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Milano Curated by ChEMBL					Assay Description Displacement of [3H]-epibatidine from human alpha3beta4 nACh receptor expressed in HEK293 cells preincubated for 5 mins followed by radioligand addit...				Eur J Med Chem 108: 392-405 (2016) Article DOI: 10.1016/j.ejmech.2015.11.045 BindingDB Entry DOI: 10.7270/Q2ZS2ZCH
Universit£ degli Studi di Milano Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit (Rattus norvegicus (Rat))	BDBM50162987 (6-[5-((S)-1-Methyl-pyrrolidin-2-ylmethoxy)-pyridin...) Show SMILES CN1CCC[C@H]1COc1cncc(c1)C#CCCCCO Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	63	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago Curated by ChEMBL					Assay Description Inhibition of [3H]epibatidine binding to rat Nicotinic acetylcholine receptor alpha3-beta4				J Med Chem 48: 1721-4 (2005) Article DOI: 10.1021/jm0492406 BindingDB Entry DOI: 10.7270/Q2BZ65JW
University of Illinois at Chicago Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit (Rattus norvegicus (Rat))	BDBM50216347 ((1R,4R)-2-(3-pyridinyl)-2,5-diazabicyclo[2.2.1]hep...) Show SMILES C1NC2CC1N(C2)c1cccnc1 Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	65	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago Curated by ChEMBL					Assay Description Displacement of [3H]epibatidine from rat alpha3beta4 nAChR by liquid scintillation counting				Eur J Med Chem 124: 689-697 (2016) Article DOI: 10.1016/j.ejmech.2016.09.016 BindingDB Entry DOI: 10.7270/Q2H41TDB
University of Illinois at Chicago Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit (Rattus norvegicus (Rat))	BDBM50162989 (10-[5-((S)-1-Methyl-pyrrolidin-2-ylmethoxy)-pyridi...) Show SMILES CN1CCC[C@H]1COc1cncc(c1)C#CCCCCCCCCO Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	66	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago Curated by ChEMBL					Assay Description Inhibition of [3H]epibatidine binding to rat Nicotinic acetylcholine receptor alpha3-beta4				J Med Chem 48: 1721-4 (2005) Article DOI: 10.1021/jm0492406 BindingDB Entry DOI: 10.7270/Q2BZ65JW
University of Illinois at Chicago Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit (Rattus norvegicus (Rat))	BDBM50162986 (3-Ethynyl-5-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-...) Show SMILES CN1CCC[C@H]1COc1cncc(c1)C#C Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	68	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago Curated by ChEMBL					Assay Description Inhibition of [3H]epibatidine binding to rat Nicotinic acetylcholine receptor alpha3-beta4				J Med Chem 48: 1721-4 (2005) Article DOI: 10.1021/jm0492406 BindingDB Entry DOI: 10.7270/Q2BZ65JW
University of Illinois at Chicago Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit (HUMAN)	BDBM50140292 (CHEMBL3759852) Show SMILES Brc1cc(Br)cc(c1)C1=NCCCC1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	71	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Milano Curated by ChEMBL					Assay Description Displacement of [3H]-epibatidine from human alpha3beta4 nACh receptor expressed in HEK293 cells preincubated for 5 mins followed by radioligand addit...				Eur J Med Chem 108: 392-405 (2016) Article DOI: 10.1016/j.ejmech.2015.11.045 BindingDB Entry DOI: 10.7270/Q2ZS2ZCH
Universit£ degli Studi di Milano Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit (Rattus norvegicus (Rat))	BDBM50049750 ((S)-3-(azetidin-2-ylmethoxy)pyridine \| 3-((S)-1-Az...) Show SMILES C(Oc1cccnc1)[C@@H]1CCN1 Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	72	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Georgetown University School of Medicine Curated by ChEMBL					Assay Description Binding affinity towards rat Nicotinic acetylcholine receptor alpha3-beta2 expressed in HEK293 cells using [3H]EB as radioligand				Bioorg Med Chem Lett 14: 1845-8 (2004) Article DOI: 10.1016/j.bmcl.2003.09.105 BindingDB Entry DOI: 10.7270/Q2TB17G2
Georgetown University School of Medicine Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit (HUMAN)	BDBM50140288 (CHEMBL3759731) Show SMILES Clc1cccc(c1)C1=NCCCC1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	77	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Milano Curated by ChEMBL					Assay Description Displacement of [3H]-epibatidine from human alpha3beta4 nACh receptor expressed in HEK293 cells preincubated for 5 mins followed by radioligand addit...				Eur J Med Chem 108: 392-405 (2016) Article DOI: 10.1016/j.ejmech.2015.11.045 BindingDB Entry DOI: 10.7270/Q2ZS2ZCH
Universit£ degli Studi di Milano Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit (HUMAN)	BDBM50139125 (CHEMBL3760021) Show SMILES Oc1cccc(c1)[C@H]1C[C@@H]2CC[C@H]1N2 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Milano Curated by ChEMBL					Assay Description Displacement of [3H]-epibatidine from human alpha3beta4 nACh receptor expressed in HEK293 cells preincubated for 5 mins followed by radioligand addit...				Eur J Med Chem 108: 392-405 (2016) Article DOI: 10.1016/j.ejmech.2015.11.045 BindingDB Entry DOI: 10.7270/Q2ZS2ZCH
Universit£ degli Studi di Milano Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit (HUMAN)	BDBM50142626 (CHEMBL3758480) Show SMILES OCc1cc(F)cc(c1)C1=NCCCC1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Milano Curated by ChEMBL					Assay Description Displacement of [3H]-epibatidine from human alpha3beta4 nACh receptor expressed in HEK293 cells preincubated for 5 mins followed by radioligand addit...				Eur J Med Chem 108: 392-405 (2016) Article DOI: 10.1016/j.ejmech.2015.11.045 BindingDB Entry DOI: 10.7270/Q2ZS2ZCH
Universit£ degli Studi di Milano Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit (HUMAN)	BDBM50139124 (CHEMBL3759208) Show SMILES OCc1cccc(c1)C1=NCCCC1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Milano Curated by ChEMBL					Assay Description Displacement of [3H]-epibatidine from human alpha3beta4 nACh receptor expressed in HEK293 cells preincubated for 5 mins followed by radioligand addit...				Eur J Med Chem 108: 392-405 (2016) Article DOI: 10.1016/j.ejmech.2015.11.045 BindingDB Entry DOI: 10.7270/Q2ZS2ZCH
Universit£ degli Studi di Milano Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit (Rattus norvegicus (Rat))	BDBM50097613 (3-((S)-1-Methyl-pyrrolidin-2-ylmethoxy)-5-phenylet...) Show SMILES CN1CCC[C@H]1COc1cncc(c1)C#Cc1ccccc1 Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	81	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago Curated by ChEMBL					Assay Description Inhibition of [3H]epibatidine binding to rat Nicotinic acetylcholine receptor alpha3-beta4				J Med Chem 48: 1721-4 (2005) Article DOI: 10.1021/jm0492406 BindingDB Entry DOI: 10.7270/Q2BZ65JW
University of Illinois at Chicago Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit (Rattus norvegicus (Rat))	BDBM50452054 (CHEMBL53620) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	82	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago Curated by ChEMBL					Assay Description Binding affinity towards nicotinic acetylcholine receptor alpha2-beta2 using [3H]epibatidine				Bioorg Med Chem Lett 14: 1855-8 (2004) Article DOI: 10.1016/j.bmcl.2003.10.071 BindingDB Entry DOI: 10.7270/Q269753N
University of Illinois at Chicago Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit (Rattus norvegicus (Rat))	BDBM50162984 (3-(6-Fluoro-hex-1-ynyl)-5-((S)-1-methyl-pyrrolidin...) Show SMILES CN1CCC[C@H]1COc1cncc(c1)C#CCCCCF Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	88	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago Curated by ChEMBL					Assay Description Inhibition of [3H]epibatidine binding to rat Nicotinic acetylcholine receptor alpha3-beta4				J Med Chem 48: 1721-4 (2005) Article DOI: 10.1021/jm0492406 BindingDB Entry DOI: 10.7270/Q2BZ65JW
University of Illinois at Chicago Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit (HUMAN)	BDBM50137787 (6-(6-Chloro-pyridin-3-yl)-8-aza-bicyclo[3.2.1]octa...) Show SMILES OC1CC2CC(C(C1)N2)c1ccc(Cl)nc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	88	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Wollongong Curated by ChEMBL					Assay Description Binding affinity against nicotinic acetylcholine receptor alpha4-beta2 using [3H]epibatidine as radioligand expressed in HEK293 cells or tsA cells				Bioorg Med Chem Lett 14: 271-3 (2003) Article DOI: 10.1016/j.bmcl.2003.09.081 BindingDB Entry DOI: 10.7270/Q2MC8ZD0
University of Wollongong Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit (HUMAN)	BDBM50142625 (CHEMBL3758513) Show SMILES OCc1cccc(c1)[C@H]1C[C@@H]2CC[C@H]1N2 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	92	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Milano Curated by ChEMBL					Assay Description Displacement of [3H]-epibatidine from human alpha3beta4 nACh receptor expressed in HEK293 cells preincubated for 5 mins followed by radioligand addit...				Eur J Med Chem 108: 392-405 (2016) Article DOI: 10.1016/j.ejmech.2015.11.045 BindingDB Entry DOI: 10.7270/Q2ZS2ZCH
Universit£ degli Studi di Milano Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit (HUMAN)	BDBM109773 (US8609708, 74 Anabaseine) Show SMILES C1CCC(=NC1)c1cccnc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	107	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Milano Curated by ChEMBL					Assay Description Displacement of [3H]-epibatidine from human alpha3beta4 nACh receptor expressed in HEK293 cells preincubated for 5 mins followed by radioligand addit...				Eur J Med Chem 108: 392-405 (2016) Article DOI: 10.1016/j.ejmech.2015.11.045 BindingDB Entry DOI: 10.7270/Q2ZS2ZCH
Universit£ degli Studi di Milano Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit (HUMAN)	BDBM50140287 (CHEMBL3758648) Show SMILES Fc1cccc(c1)C1=NCCCC1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	108	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Milano Curated by ChEMBL					Assay Description Displacement of [3H]-epibatidine from human alpha3beta4 nACh receptor expressed in HEK293 cells preincubated for 5 mins followed by radioligand addit...				Eur J Med Chem 108: 392-405 (2016) Article DOI: 10.1016/j.ejmech.2015.11.045 BindingDB Entry DOI: 10.7270/Q2ZS2ZCH
Universit£ degli Studi di Milano Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit (Rattus norvegicus (Rat))	BDBM50452053 (CHEMBL55732) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	112	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago Curated by ChEMBL					Assay Description Binding affinity towards Nicotinic acetylcholine receptor alpha4-beta4 using [3H]epibatidine				Bioorg Med Chem Lett 14: 1855-8 (2004) Article DOI: 10.1016/j.bmcl.2003.10.071 BindingDB Entry DOI: 10.7270/Q269753N
University of Illinois at Chicago Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit (HUMAN)	BDBM50203723 (CHEMBL3930193) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	122	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Milano Curated by ChEMBL					Assay Description Displacement of [3H]-epibatine from human alpha3beta4-nACHR expressed in HEK243 cell membranes preincubated for 5 mins followed by overnight incubati...				Bioorg Med Chem Lett 26: 5613-5617 (2016) Article DOI: 10.1016/j.bmcl.2016.10.078 BindingDB Entry DOI: 10.7270/Q2RJ4MFR
Universit£ degli Studi di Milano Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit (Rattus norvegicus (Rat))	BDBM50452055 (CHEMBL56045) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	138	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago Curated by ChEMBL					Assay Description Binding affinity towards Nicotinic acetylcholine receptor alpha4-beta2 using [3H]epibatidine				Bioorg Med Chem Lett 14: 1855-8 (2004) Article DOI: 10.1016/j.bmcl.2003.10.071 BindingDB Entry DOI: 10.7270/Q269753N
University of Illinois at Chicago Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit (HUMAN)	BDBM50203717 (CHEMBL3952327) Show SMILES CN1CCC[C@H]1COc1cc(O)cc(Br)c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	147	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Milano Curated by ChEMBL					Assay Description Displacement of [3H]-epibatine from human alpha3beta4-nACHR expressed in HEK243 cell membranes preincubated for 5 mins followed by overnight incubati...				Bioorg Med Chem Lett 26: 5613-5617 (2016) Article DOI: 10.1016/j.bmcl.2016.10.078 BindingDB Entry DOI: 10.7270/Q2RJ4MFR
Universit£ degli Studi di Milano Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit (HUMAN)	BDBM50142623 (CHEMBL3758565) Show SMILES Cc1cccc(c1)C1=NCCCC1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	155	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Milano Curated by ChEMBL					Assay Description Displacement of [3H]-epibatidine from human alpha3beta4 nACh receptor expressed in HEK293 cells preincubated for 5 mins followed by radioligand addit...				Eur J Med Chem 108: 392-405 (2016) Article DOI: 10.1016/j.ejmech.2015.11.045 BindingDB Entry DOI: 10.7270/Q2ZS2ZCH
Universit£ degli Studi di Milano Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit (Rattus norvegicus (Rat))	BDBM50331016 (6-benzyl-3-(pyridin-3-yl)-6-azabicyclo[3.2.2]non-2...) Show SMILES C(N1CC2CCC1CC(=C2)c1cccnc1)c1ccccc1 Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	170	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
SRI International Curated by ChEMBL					Assay Description Displacement of [3H]epibatidine from rat alpha3beta4 nAChR expressed in HEK292 cells after 3 hrs				J Med Chem 53: 8187-91 (2010) Article DOI: 10.1021/jm1006148 BindingDB Entry DOI: 10.7270/Q2MC9080
SRI International Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit (HUMAN)	BDBM50142624 (CHEMBL3759403) Show SMILES C1CCC(=NC1)c1ccccc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	194	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Milano Curated by ChEMBL					Assay Description Displacement of [3H]-epibatidine from human alpha3beta4 nACh receptor expressed in HEK293 cells preincubated for 5 mins followed by radioligand addit...				Eur J Med Chem 108: 392-405 (2016) Article DOI: 10.1016/j.ejmech.2015.11.045 BindingDB Entry DOI: 10.7270/Q2ZS2ZCH
Universit£ degli Studi di Milano Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit (HUMAN)	BDBM50203720 (CHEMBL3928806) Show SMILES CN1CCC[C@H]1COc1cc(O)cc(c1)-c1ccccc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Milano Curated by ChEMBL					Assay Description Displacement of [3H]-epibatine from human alpha3beta4-nACHR expressed in HEK243 cell membranes preincubated for 5 mins followed by overnight incubati...				Bioorg Med Chem Lett 26: 5613-5617 (2016) Article DOI: 10.1016/j.bmcl.2016.10.078 BindingDB Entry DOI: 10.7270/Q2RJ4MFR
Universit£ degli Studi di Milano Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit (Rattus norvegicus (Rat))	BDBM50143282 ((-)-cytisine \| (1R,5S)-1,2,3,4,5,6-Hexahydro-1,5-m...) Show SMILES O=c1cccc2[C@H]3CNC[C@H](C3)Cn12 Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	203	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
SRI International Curated by ChEMBL					Assay Description Displacement of [3H]epibatidine from rat alpha3beta4 nAChR expressed in HEK292 cells after 3 hrs				J Med Chem 53: 8187-91 (2010) Article DOI: 10.1021/jm1006148 BindingDB Entry DOI: 10.7270/Q2MC9080
SRI International Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit (Rattus norvegicus (Rat))	BDBM50143282 ((-)-cytisine \| (1R,5S)-1,2,3,4,5,6-Hexahydro-1,5-m...) Show SMILES O=c1cccc2[C@H]3CNC[C@H](C3)Cn12 Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	210	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Georgetown University School of Medicine Curated by ChEMBL					Assay Description Binding affinity towards rat Nicotinic acetylcholine receptor alpha4-beta2 expressed in HEK293 cells using [3H]EB as radioligand				Bioorg Med Chem Lett 14: 1845-8 (2004) Article DOI: 10.1016/j.bmcl.2003.09.105 BindingDB Entry DOI: 10.7270/Q2TB17G2
Georgetown University School of Medicine Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit (Rattus norvegicus (Rat))	BDBM50100715 (2-(6-Bromo-pyridin-3-yl)-7-aza-bicyclo[2.2.1]hepta...) Show SMILES Brc1ccc(cn1)C1CC2CCC1N2 Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	220	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Research Triangle Institute Curated by ChEMBL					Assay Description Inhibition of [3H]-nicotine binding to alpha4-beta2 nACh receptor from rat membranes from ref 18				Bioorg Med Chem Lett 14: 1889-96 (2004) Article DOI: 10.1016/j.bmcl.2004.02.007 BindingDB Entry DOI: 10.7270/Q2S75FR9
Research Triangle Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit (Rattus norvegicus (Rat))	BDBM50331014 (9-methyl-3-(pyridin-3-yl)-9-azabicyclo[3.3.1]non-2...) Show SMILES CN1C2CCCC1C=C(C2)c1cccnc1 Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	241	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
SRI International Curated by ChEMBL					Assay Description Displacement of [3H]epibatidine from rat alpha3beta4 nAChR expressed in HEK292 cells after 3 hrs				J Med Chem 53: 8187-91 (2010) Article DOI: 10.1021/jm1006148 BindingDB Entry DOI: 10.7270/Q2MC9080
SRI International Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit (HUMAN)	BDBM82070 (CAS_29790-52-1 \| NICOTINE-L (BASE) \| Nicotine-D sa...) Show SMILES CN1CCC[C@H]1c1cccnc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	260	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Milano Curated by ChEMBL					Assay Description Displacement of [3H]-epibatine from human alpha3beta4-nACHR expressed in HEK243 cell membranes preincubated for 5 mins followed by overnight incubati...				Bioorg Med Chem Lett 26: 5613-5617 (2016) Article DOI: 10.1016/j.bmcl.2016.10.078 BindingDB Entry DOI: 10.7270/Q2RJ4MFR
Universit£ degli Studi di Milano Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit (HUMAN)	BDBM82070 (CAS_29790-52-1 \| NICOTINE-L (BASE) \| Nicotine-D sa...) Show SMILES CN1CCC[C@H]1c1cccnc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	260	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Displacement of [3H]epibatidine from alpha3beta4 nAChR after 4 hrs by liquid scintillation counting analysis				ACS Med Chem Lett 3: 1054-1058 (2012) Article DOI: 10.1021/ml3002715 BindingDB Entry DOI: 10.7270/Q25M66WS
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit (HUMAN)	BDBM50006616 (CHEMBL3235484) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	261	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Johns Hopkins University School of Medicine Curated by ChEMBL					Assay Description Displacement of [3H]epibatidine from alpha3beta4-nAChR (unknown origin) expressed in HEK293 cells after 2 hrs by liquid scintillation counting analys...				J Med Chem 56: 7574-89 (2013) Article DOI: 10.1021/jm401184f BindingDB Entry DOI: 10.7270/Q2Z3215R
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit (Rattus norvegicus (Rat))	BDBM50001695 (CHEMBL3238085) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	270	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Torrey Pines Institute for Molecular Studies Curated by ChEMBL					Assay Description Displacement of [3H]epibatadine from rat alpha3beta4 nAChR expressed in HEK293 cells after 2 hrs by betaplate counting analysis				J Med Chem 57: 3511-21 (2014) Article DOI: 10.1021/jm500183r BindingDB Entry DOI: 10.7270/Q2ZC84CQ
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit (Rattus norvegicus (Rat))	BDBM50143281 (3-((S)-Azetidin-2-yloxy)-5-iodo-pyridine \| CHEMBL5...) Show SMILES Ic1cncc(O[C@H]2CCN2)c1 Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	290	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Georgetown University School of Medicine Curated by ChEMBL					Assay Description Binding affinity of the compound was determined against Nicotinic acetylcholine receptor using [3H]-(-)-nicotine radioligand				Bioorg Med Chem Lett 14: 1845-8 (2004) Article DOI: 10.1016/j.bmcl.2003.09.105 BindingDB Entry DOI: 10.7270/Q2TB17G2
Georgetown University School of Medicine Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit (Rattus norvegicus (Rat))	BDBM50049757 (()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...) Show SMILES Clc1ccc(cn1)C1CC2CCC1N2 Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	300	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Research Triangle Institute Curated by ChEMBL					Assay Description Binding affinity towards rat Nicotinic acetylcholine receptor alpha4-beta2 expressed in Xenopus oocytes using [3H]-epibatidine as radioligand				Bioorg Med Chem Lett 14: 1889-96 (2004) Article DOI: 10.1016/j.bmcl.2004.02.007 BindingDB Entry DOI: 10.7270/Q2S75FR9
Research Triangle Institute Curated by ChEMBL					More data for this Ligand-Target Pair

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