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Compile Data Set for Download or QSAR

Found 1142 hits Enz. Inhib. hit(s) with Target = 'Bradykinin B2 receptor'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50411274
PNG
(CHEMBL220596)
Show SMILES CN(C)CCC[C@H](N)CC(=O)N1CCN(CC1)C(=O)C1(CCCC1)NS(=O)(=O)c1ccc(Cl)c(COc2cccc3c(C)cc(C)nc23)c1Cl
Show InChI InChI=1S/C36H48Cl2N6O5S/c1-24-21-25(2)40-34-27(24)10-7-11-30(34)49-23-28-29(37)12-13-31(33(28)38)50(47,48)41-36(14-5-6-15-36)35(46)44-19-17-43(18-20-44)32(45)22-26(39)9-8-16-42(3)4/h7,10-13,21,26,41H,5-6,8-9,14-20,22-23,39H2,1-4H3/t26-/m0/s1
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n/an/an/a 0.0398n/an/an/an/an/a



Menarini Ricerche

Curated by ChEMBL


Assay Description
Antagonist potency on BK-induced contraction of guinea pig ileum longitudinal smooth muscle


J Med Chem 50: 550-65 (2007)


Article DOI: 10.1021/jm061143k
BindingDB Entry DOI: 10.7270/Q2H13374
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50411275
PNG
(CHEMBL218427 | MEN-16132)
Show SMILES Cc1cc(C)c2cccc(OCc3c(Cl)ccc(c3Cl)S(=O)(=O)NC3(CCOCC3)C(=O)N3CCN(CC3)C(=O)[C@@H](N)CCC[N+](C)(C)C)c2n1
Show InChI InChI=1S/C36H49Cl2N6O6S/c1-24-22-25(2)40-33-26(24)8-6-10-30(33)50-23-27-28(37)11-12-31(32(27)38)51(47,48)41-36(13-20-49-21-14-36)35(46)43-17-15-42(16-18-43)34(45)29(39)9-7-19-44(3,4)5/h6,8,10-12,22,29,41H,7,9,13-21,23,39H2,1-5H3/q+1/t29-/m0/s1
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n/an/an/a 0.0501n/an/an/an/an/a



Menarini Ricerche

Curated by ChEMBL


Assay Description
Antagonist activity at human bradykinin B2 receptor expressed in dhfr-deficient CHO cells assessed as inhibition of bradykinin-induced inositol monop...


Bioorg Med Chem 20: 2091-100 (2012)


Article DOI: 10.1016/j.bmc.2012.01.036
BindingDB Entry DOI: 10.7270/Q2PN96WX
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50411275
PNG
(CHEMBL218427 | MEN-16132)
Show SMILES Cc1cc(C)c2cccc(OCc3c(Cl)ccc(c3Cl)S(=O)(=O)NC3(CCOCC3)C(=O)N3CCN(CC3)C(=O)[C@@H](N)CCC[N+](C)(C)C)c2n1
Show InChI InChI=1S/C36H49Cl2N6O6S/c1-24-22-25(2)40-33-26(24)8-6-10-30(33)50-23-27-28(37)11-12-31(32(27)38)51(47,48)41-36(13-20-49-21-14-36)35(46)43-17-15-42(16-18-43)34(45)29(39)9-7-19-44(3,4)5/h6,8,10-12,22,29,41H,7,9,13-21,23,39H2,1-5H3/q+1/t29-/m0/s1
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Menarini Ricerche

Curated by ChEMBL


Assay Description
Antagonist potency at human bradykinin B2 receptor assessed as effect on inositol monophosphate accumulation in CHOdhfr- cells


J Med Chem 50: 550-65 (2007)


Article DOI: 10.1021/jm061143k
BindingDB Entry DOI: 10.7270/Q2H13374
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50419902
PNG
(CHEMBL1956722)
Show SMILES Cc1cc(C)c2cccc(OCc3c(Cl)ccc(c3Cl)S(=O)(=O)NC3(CCOCC3)C(=O)N3CCN(CC3)C(=O)CCCC[N+](C)(C)C)c2n1
Show InChI InChI=1S/C36H48Cl2N5O6S/c1-25-23-26(2)39-34-27(25)9-8-10-30(34)49-24-28-29(37)12-13-31(33(28)38)50(46,47)40-36(14-21-48-22-15-36)35(45)42-18-16-41(17-19-42)32(44)11-6-7-20-43(3,4)5/h8-10,12-13,23,40H,6-7,11,14-22,24H2,1-5H3/q+1
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n/an/an/a 0.0631n/an/an/an/an/a



Menarini Ricerche

Curated by ChEMBL


Assay Description
Antagonist activity at guinea pig bradykinin B2 receptor in longitudinal smooth muscle assessed as inhibition of bradykinin-induced contractile respo...


Bioorg Med Chem 20: 2091-100 (2012)


Article DOI: 10.1016/j.bmc.2012.01.036
BindingDB Entry DOI: 10.7270/Q2PN96WX
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50411261
PNG
(CHEMBL375820)
Show SMILES Cc1cc(C)c2cccc(OCc3c(Cl)ccc(c3Cl)S(=O)(=O)NC(C)(C)C(=O)N3CCN(CC3)C(=O)[C@@H](N)CCCCN=C(N)N)c2n1
Show InChI InChI=1S/C33H44Cl2N8O5S/c1-20-18-21(2)40-29-22(20)8-7-10-26(29)48-19-23-24(34)11-12-27(28(23)35)49(46,47)41-33(3,4)31(45)43-16-14-42(15-17-43)30(44)25(36)9-5-6-13-39-32(37)38/h7-8,10-12,18,25,41H,5-6,9,13-17,19,36H2,1-4H3,(H4,37,38,39)/t25-/m0/s1
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Menarini Ricerche

Curated by ChEMBL


Assay Description
Antagonist potency on BK-induced contraction of guinea pig ileum longitudinal smooth muscle


J Med Chem 50: 550-65 (2007)


Article DOI: 10.1021/jm061143k
BindingDB Entry DOI: 10.7270/Q2H13374
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50411248
PNG
(CHEMBL375689)
Show SMILES Cc1cc(C)c2cccc(OCc3c(Cl)ccc(c3Cl)S(=O)(=O)NC3(CCCC3)C(=O)N3CCN(CC3)C(=O)[C@@H](N)CCCCN=C(N)N)c2n1
Show InChI InChI=1S/C35H46Cl2N8O5S/c1-22-20-23(2)42-31-24(22)8-7-10-28(31)50-21-25-26(36)11-12-29(30(25)37)51(48,49)43-35(13-4-5-14-35)33(47)45-18-16-44(17-19-45)32(46)27(38)9-3-6-15-41-34(39)40/h7-8,10-12,20,27,43H,3-6,9,13-19,21,38H2,1-2H3,(H4,39,40,41)/t27-/m0/s1
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Menarini Ricerche

Curated by ChEMBL


Assay Description
Antagonist potency on BK-induced contraction of guinea pig ileum longitudinal smooth muscle


J Med Chem 50: 550-65 (2007)


Article DOI: 10.1021/jm061143k
BindingDB Entry DOI: 10.7270/Q2H13374
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50410927
PNG
(CHEMBL205093)
Show SMILES CN(C)CCC[C@H](N)CC(=O)N1CCN(CC1)C(=O)C(C)(C)NS(=O)(=O)c1ccc(Cl)c(COc2cccc3c(C)cc(C)nc23)c1Cl
Show InChI InChI=1S/C34H46Cl2N6O5S/c1-22-19-23(2)38-32-25(22)10-7-11-28(32)47-21-26-27(35)12-13-29(31(26)36)48(45,46)39-34(3,4)33(44)42-17-15-41(16-18-42)30(43)20-24(37)9-8-14-40(5)6/h7,10-13,19,24,39H,8-9,14-18,20-21,37H2,1-6H3/t24-/m0/s1
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Menarini Ricerche

Curated by ChEMBL


Assay Description
Antagonist potency on BK-induced contraction of guinea pig ileum longitudinal smooth muscle


J Med Chem 50: 550-65 (2007)


Article DOI: 10.1021/jm061143k
BindingDB Entry DOI: 10.7270/Q2H13374
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50410917
PNG
(CHEMBL380273 | MEN-15442)
Show SMILES CN(C)CCC[C@H](N)C(=O)N1CCN(CC1)C(=O)C(C)(C)NS(=O)(=O)c1ccc(Cl)c(COc2cccc3c(C)cc(C)nc23)c1Cl
Show InChI InChI=1S/C33H44Cl2N6O5S/c1-21-19-22(2)37-30-23(21)9-7-11-27(30)46-20-24-25(34)12-13-28(29(24)35)47(44,45)38-33(3,4)32(43)41-17-15-40(16-18-41)31(42)26(36)10-8-14-39(5)6/h7,9,11-13,19,26,38H,8,10,14-18,20,36H2,1-6H3/t26-/m0/s1
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Menarini Ricerche

Curated by ChEMBL


Assay Description
Antagonist potency on BK-induced contraction of guinea pig ileum longitudinal smooth muscle


J Med Chem 50: 550-65 (2007)


Article DOI: 10.1021/jm061143k
BindingDB Entry DOI: 10.7270/Q2H13374
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50419924
PNG
(CHEMBL1956856)
Show SMILES CN(C)CCC[C@H](N)C(=O)N1CCN(CC1)C(=O)C1(CCOCC1)NS(=O)(=O)c1ccc(Cl)c(COc2cccc3c(C)cc(C)nc23)c1Cl
Show InChI InChI=1S/C35H46Cl2N6O6S/c1-23-21-24(2)39-32-25(23)7-5-9-29(32)49-22-26-27(36)10-11-30(31(26)37)50(46,47)40-35(12-19-48-20-13-35)34(45)43-17-15-42(16-18-43)33(44)28(38)8-6-14-41(3)4/h5,7,9-11,21,28,40H,6,8,12-20,22,38H2,1-4H3/t28-/m0/s1
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Menarini Ricerche

Curated by ChEMBL


Assay Description
Antagonist activity at human bradykinin B2 receptor expressed in dhfr-deficient CHO cells assessed as inhibition of bradykinin-induced inositol monop...


Bioorg Med Chem 20: 2091-100 (2012)


Article DOI: 10.1016/j.bmc.2012.01.036
BindingDB Entry DOI: 10.7270/Q2PN96WX
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50411249
PNG
(CHEMBL415366)
Show SMILES Cc1cc(C)c2cccc(OCc3c(Cl)ccc(c3Cl)S(=O)(=O)NC3(CCSCC3)C(=O)N3CCN(CC3)C(=O)[C@@H](N)CCC[N+](C)(C)C)c2n1
Show InChI InChI=1S/C36H49Cl2N6O5S2/c1-24-22-25(2)40-33-26(24)8-6-10-30(33)49-23-27-28(37)11-12-31(32(27)38)51(47,48)41-36(13-20-50-21-14-36)35(46)43-17-15-42(16-18-43)34(45)29(39)9-7-19-44(3,4)5/h6,8,10-12,22,29,41H,7,9,13-21,23,39H2,1-5H3/q+1/t29-/m0/s1
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n/an/an/a 0.158n/an/an/an/an/a



Menarini Ricerche

Curated by ChEMBL


Assay Description
Antagonist potency at human bradykinin B2 receptor assessed as effect on inositol monophosphate accumulation in CHOdhfr- cells


J Med Chem 50: 550-65 (2007)


Article DOI: 10.1021/jm061143k
BindingDB Entry DOI: 10.7270/Q2H13374
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50411250
PNG
(CHEMBL220595)
Show SMILES CN(C)CCCC[C@H](N)C(=O)N1CCN(CC1)C(=O)C1(CCCC1)NS(=O)(=O)c1ccc(Cl)c(COc2cccc3c(C)cc(C)nc23)c1Cl
Show InChI InChI=1S/C36H48Cl2N6O5S/c1-24-22-25(2)40-33-26(24)10-9-12-30(33)49-23-27-28(37)13-14-31(32(27)38)50(47,48)41-36(15-6-7-16-36)35(46)44-20-18-43(19-21-44)34(45)29(39)11-5-8-17-42(3)4/h9-10,12-14,22,29,41H,5-8,11,15-21,23,39H2,1-4H3/t29-/m0/s1
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Menarini Ricerche

Curated by ChEMBL


Assay Description
Antagonist potency on BK-induced contraction of guinea pig ileum longitudinal smooth muscle


J Med Chem 50: 550-65 (2007)


Article DOI: 10.1021/jm061143k
BindingDB Entry DOI: 10.7270/Q2H13374
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50410922
PNG
(CHEMBL383167)
Show SMILES CN(C)CCCC[C@H](N)C(=O)N1CCN(CC1)C(=O)C(C)(C)NS(=O)(=O)c1ccc(Cl)c(COc2cccc3c(C)cc(C)nc23)c1Cl
Show InChI InChI=1S/C34H46Cl2N6O5S/c1-22-20-23(2)38-31-24(22)10-9-12-28(31)47-21-25-26(35)13-14-29(30(25)36)48(45,46)39-34(3,4)33(44)42-18-16-41(17-19-42)32(43)27(37)11-7-8-15-40(5)6/h9-10,12-14,20,27,39H,7-8,11,15-19,21,37H2,1-6H3/t27-/m0/s1
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Menarini Ricerche

Curated by ChEMBL


Assay Description
Antagonist potency on BK-induced contraction of guinea pig ileum longitudinal smooth muscle


J Med Chem 50: 550-65 (2007)


Article DOI: 10.1021/jm061143k
BindingDB Entry DOI: 10.7270/Q2H13374
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50411248
PNG
(CHEMBL375689)
Show SMILES Cc1cc(C)c2cccc(OCc3c(Cl)ccc(c3Cl)S(=O)(=O)NC3(CCCC3)C(=O)N3CCN(CC3)C(=O)[C@@H](N)CCCCN=C(N)N)c2n1
Show InChI InChI=1S/C35H46Cl2N8O5S/c1-22-20-23(2)42-31-24(22)8-7-10-28(31)50-21-25-26(36)11-12-29(30(25)37)51(48,49)43-35(13-4-5-14-35)33(47)45-18-16-44(17-19-45)32(46)27(38)9-3-6-15-41-34(39)40/h7-8,10-12,20,27,43H,3-6,9,13-19,21,38H2,1-2H3,(H4,39,40,41)/t27-/m0/s1
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Menarini Ricerche

Curated by ChEMBL


Assay Description
Antagonist potency at human bradykinin B2 receptor assessed as effect on inositol monophosphate accumulation in CHOdhfr- cells


J Med Chem 50: 550-65 (2007)


Article DOI: 10.1021/jm061143k
BindingDB Entry DOI: 10.7270/Q2H13374
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50411268
PNG
(CHEMBL373607)
Show SMILES CN1CCC(CC1)(NS(=O)(=O)c1ccc(Cl)c(COc2cccc3c(C)cc(C)nc23)c1Cl)C(=O)N1CCN(CC1)C(=O)[C@@H](N)CCC[N+](C)(C)C
Show InChI InChI=1S/C37H52Cl2N7O5S/c1-25-23-26(2)41-34-27(25)9-7-11-31(34)51-24-28-29(38)12-13-32(33(28)39)52(49,50)42-37(14-16-43(3)17-15-37)36(48)45-20-18-44(19-21-45)35(47)30(40)10-8-22-46(4,5)6/h7,9,11-13,23,30,42H,8,10,14-22,24,40H2,1-6H3/q+1/t30-/m0/s1
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Menarini Ricerche

Curated by ChEMBL


Assay Description
Antagonist potency at human bradykinin B2 receptor assessed as effect on inositol monophosphate accumulation in CHOdhfr- cells


J Med Chem 50: 550-65 (2007)


Article DOI: 10.1021/jm061143k
BindingDB Entry DOI: 10.7270/Q2H13374
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50403372
PNG
(CHEMBL437155)
Show SMILES C[C@]12C[C@H](N(C(=O)[C@H]3Cc4ccccc4CN3C(=O)[C@H](CO)NC(=O)[C@H](Cc3cccs3)NC(=O)CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@H]3CCCN3C(=O)[C@H](CCCNC(N)=N)NC(=O)c3ccc(NC(=N)CN)cc3)[C@@]1(C)CCCC2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O
Show InChI InChI=1S/C64H90N18O13S/c1-63-21-5-6-22-64(63,2)82(49(30-63)55(89)77-43(60(94)95)15-8-24-72-62(69)70)59(93)48-27-37-11-3-4-12-38(37)33-80(48)57(91)45(35-83)78-53(87)44(29-41-13-10-26-96-41)75-51(85)32-73-54(88)47-28-40(84)34-81(47)58(92)46-16-9-25-79(46)56(90)42(14-7-23-71-61(67)68)76-52(86)36-17-19-39(20-18-36)74-50(66)31-65/h3-4,10-13,17-20,26,40,42-49,83-84H,5-9,14-16,21-25,27-35,65H2,1-2H3,(H2,66,74)(H,73,88)(H,75,85)(H,76,86)(H,77,89)(H,78,87)(H,94,95)(H4,67,68,71)(H4,69,70,72)/t40-,42+,43+,44+,45+,46-,47+,48-,49+,63+,64+/m1/s1
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n/an/an/a 0.263n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonist effect against bradykinin B2 receptor was determined in rabbit jugular vein


Bioorg Med Chem Lett 4: 781-784 (1994)


Article DOI: 10.1016/S0960-894X(01)80847-7
BindingDB Entry DOI: 10.7270/Q2NP25KV
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50403371
PNG
(Firazyr | HOE-140 | ICATIBANT)
Show SMILES N[C@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N1[C@H]2CCCC[C@H]2C[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(O)=O
Show InChI InChI=1S/C59H89N19O13S/c60-37(14-5-19-67-57(61)62)48(82)72-38(15-6-20-68-58(63)64)52(86)75-22-8-18-43(75)54(88)77-30-35(80)26-44(77)50(84)70-28-47(81)71-40(27-36-13-9-23-92-36)49(83)74-41(31-79)53(87)76-29-34-12-2-1-10-32(34)24-46(76)55(89)78-42-17-4-3-11-33(42)25-45(78)51(85)73-39(56(90)91)16-7-21-69-59(65)66/h1-2,9-10,12-13,23,33,35,37-46,79-80H,3-8,11,14-22,24-31,60H2,(H,70,84)(H,71,81)(H,72,82)(H,73,85)(H,74,83)(H,90,91)(H4,61,62,67)(H4,63,64,68)(H4,65,66,69)/t33-,35+,37+,38-,39-,40-,41-,42-,43-,44-,45-,46+/m0/s1
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n/an/an/a 0.282n/an/an/an/an/a



University of Firenze and CNR-ICCOM

Curated by ChEMBL


Assay Description
Antagonist activity against bradykinin B2 receptor


Bioorg Med Chem Lett 16: 2387-90 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.125
BindingDB Entry DOI: 10.7270/Q2RN3936
More data for this
Ligand-Target Pair
BDKRB2


(RAT)
BDBM50403371
PNG
(Firazyr | HOE-140 | ICATIBANT)
Show SMILES N[C@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N1[C@H]2CCCC[C@H]2C[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(O)=O
Show InChI InChI=1S/C59H89N19O13S/c60-37(14-5-19-67-57(61)62)48(82)72-38(15-6-20-68-58(63)64)52(86)75-22-8-18-43(75)54(88)77-30-35(80)26-44(77)50(84)70-28-47(81)71-40(27-36-13-9-23-92-36)49(83)74-41(31-79)53(87)76-29-34-12-2-1-10-32(34)24-46(76)55(89)78-42-17-4-3-11-33(42)25-45(78)51(85)73-39(56(90)91)16-7-21-69-59(65)66/h1-2,9-10,12-13,23,33,35,37-46,79-80H,3-8,11,14-22,24-31,60H2,(H,70,84)(H,71,81)(H,72,82)(H,73,85)(H,74,83)(H,90,91)(H4,61,62,67)(H4,63,64,68)(H4,65,66,69)/t33-,35+,37+,38-,39-,40-,41-,42-,43-,44-,45-,46+/m0/s1
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n/an/an/a 0.316n/an/an/an/an/a



Cortech, Inc.

Curated by ChEMBL


Assay Description
In vitro Bradykinin receptor B2 antagonist activity by using rat uterus functional assay


J Med Chem 39: 1472-84 (1996)


Article DOI: 10.1021/jm950716i
BindingDB Entry DOI: 10.7270/Q2HQ413S
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50411272
PNG
(CHEMBL387452)
Show SMILES Cc1cc(C)c2cccc(OCc3c(Cl)ccc(c3Cl)S(=O)(=O)NC3(CCCC3)C(=O)N3CCN(CC3)C(=O)[C@@H](N)CCC[N+](C)(C)C)c2n1
Show InChI InChI=1S/C36H49Cl2N6O5S/c1-24-22-25(2)40-33-26(24)10-8-12-30(33)49-23-27-28(37)13-14-31(32(27)38)50(47,48)41-36(15-6-7-16-36)35(46)43-19-17-42(18-20-43)34(45)29(39)11-9-21-44(3,4)5/h8,10,12-14,22,29,41H,6-7,9,11,15-21,23,39H2,1-5H3/q+1/t29-/m0/s1
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n/an/an/a 0.316n/an/an/an/an/a



Menarini Ricerche

Curated by ChEMBL


Assay Description
Antagonist potency at human bradykinin B2 receptor assessed as effect on inositol monophosphate accumulation in CHOdhfr- cells


J Med Chem 50: 550-65 (2007)


Article DOI: 10.1021/jm061143k
BindingDB Entry DOI: 10.7270/Q2H13374
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50411262
PNG
(CHEMBL207939 | LF-16-0687)
Show SMILES Cc1cc(C)c2cccc(OCc3c(Cl)ccc(c3Cl)S(=O)(=O)N3CCC[C@@H]3C(=O)NCCCNC(=O)c3ccc(cc3)C(N)=N)c2n1
Show InChI InChI=1S/C34H36Cl2N6O5S/c1-20-18-21(2)41-31-24(20)6-3-8-28(31)47-19-25-26(35)13-14-29(30(25)36)48(45,46)42-17-4-7-27(42)34(44)40-16-5-15-39-33(43)23-11-9-22(10-12-23)32(37)38/h3,6,8-14,18,27H,4-5,7,15-17,19H2,1-2H3,(H3,37,38)(H,39,43)(H,40,44)/t27-/m1/s1
MMDB

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n/an/an/a 0.316n/an/an/an/an/a



Menarini Ricerche

Curated by ChEMBL


Assay Description
Antagonist potency on BK-induced contraction of guinea pig ileum longitudinal smooth muscle


J Med Chem 50: 550-65 (2007)


Article DOI: 10.1021/jm061143k
BindingDB Entry DOI: 10.7270/Q2H13374
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50419902
PNG
(CHEMBL1956722)
Show SMILES Cc1cc(C)c2cccc(OCc3c(Cl)ccc(c3Cl)S(=O)(=O)NC3(CCOCC3)C(=O)N3CCN(CC3)C(=O)CCCC[N+](C)(C)C)c2n1
Show InChI InChI=1S/C36H48Cl2N5O6S/c1-25-23-26(2)39-34-27(25)9-8-10-30(34)49-24-28-29(37)12-13-31(33(28)38)50(46,47)40-36(14-21-48-22-15-36)35(45)42-18-16-41(17-19-42)32(44)11-6-7-20-43(3,4)5/h8-10,12-13,23,40H,6-7,11,14-22,24H2,1-5H3/q+1
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n/an/an/a 0.316n/an/an/an/an/a



Menarini Ricerche

Curated by ChEMBL


Assay Description
Antagonist activity at human bradykinin B2 receptor expressed in dhfr-deficient CHO cells assessed as inhibition of bradykinin-induced inositol monop...


Bioorg Med Chem 20: 2091-100 (2012)


Article DOI: 10.1016/j.bmc.2012.01.036
BindingDB Entry DOI: 10.7270/Q2PN96WX
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50419910
PNG
(CHEMBL1956859)
Show SMILES Cc1cc(C)c2cccc(OCc3c(Cl)ccc(c3Cl)S(=O)(=O)NC3(CCOCC3)C(=O)N3CCN(CC3)C(=O)[C@@H](N)CCCC[N+](C)(C)C)c2n1
Show InChI InChI=1S/C37H51Cl2N6O6S/c1-25-23-26(2)41-34-27(25)9-8-11-31(34)51-24-28-29(38)12-13-32(33(28)39)52(48,49)42-37(14-21-50-22-15-37)36(47)44-18-16-43(17-19-44)35(46)30(40)10-6-7-20-45(3,4)5/h8-9,11-13,23,30,42H,6-7,10,14-22,24,40H2,1-5H3/q+1/t30-/m0/s1
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n/an/an/a 0.398n/an/an/an/an/a



Menarini Ricerche

Curated by ChEMBL


Assay Description
Antagonist activity at human bradykinin B2 receptor expressed in dhfr-deficient CHO cells assessed as inhibition of bradykinin-induced inositol monop...


Bioorg Med Chem 20: 2091-100 (2012)


Article DOI: 10.1016/j.bmc.2012.01.036
BindingDB Entry DOI: 10.7270/Q2PN96WX
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50419908
PNG
(CHEMBL1956857)
Show SMILES Cc1cc(C)c2cccc(OCc3c(Cl)ccc(c3Cl)S(=O)(=O)NC3(CCOCC3)C(=O)N3CCN(CC3)C(=O)[C@@H](N)CCCCN)c2n1
Show InChI InChI=1S/C34H44Cl2N6O6S/c1-22-20-23(2)39-31-24(22)6-5-8-28(31)48-21-25-26(35)9-10-29(30(25)36)49(45,46)40-34(11-18-47-19-12-34)33(44)42-16-14-41(15-17-42)32(43)27(38)7-3-4-13-37/h5-6,8-10,20,27,40H,3-4,7,11-19,21,37-38H2,1-2H3/t27-/m0/s1
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n/an/an/a 0.398n/an/an/an/an/a



Menarini Ricerche

Curated by ChEMBL


Assay Description
Antagonist activity at human bradykinin B2 receptor expressed in dhfr-deficient CHO cells assessed as inhibition of bradykinin-induced inositol monop...


Bioorg Med Chem 20: 2091-100 (2012)


Article DOI: 10.1016/j.bmc.2012.01.036
BindingDB Entry DOI: 10.7270/Q2PN96WX
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50411262
PNG
(CHEMBL207939 | LF-16-0687)
Show SMILES Cc1cc(C)c2cccc(OCc3c(Cl)ccc(c3Cl)S(=O)(=O)N3CCC[C@@H]3C(=O)NCCCNC(=O)c3ccc(cc3)C(N)=N)c2n1
Show InChI InChI=1S/C34H36Cl2N6O5S/c1-20-18-21(2)41-31-24(20)6-3-8-28(31)47-19-25-26(35)13-14-29(30(25)36)48(45,46)42-17-4-7-27(42)34(44)40-16-5-15-39-33(43)23-11-9-22(10-12-23)32(37)38/h3,6,8-14,18,27H,4-5,7,15-17,19H2,1-2H3,(H3,37,38)(H,39,43)(H,40,44)/t27-/m1/s1
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n/an/an/a 0.398n/an/an/an/an/a



Menarini Ricerche

Curated by ChEMBL


Assay Description
Antagonist potency at human bradykinin B2 receptor assessed as effect on inositol monophosphate accumulation in CHOdhfr- cells


J Med Chem 50: 550-65 (2007)


Article DOI: 10.1021/jm061143k
BindingDB Entry DOI: 10.7270/Q2H13374
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50419905
PNG
(CHEMBL1956853)
Show SMILES CN(C)CCCCC(=O)N1CCN(CC1)C(=O)C1(CCOCC1)NS(=O)(=O)c1ccc(Cl)c(COc2cccc3c(C)cc(C)nc23)c1Cl
Show InChI InChI=1S/C35H45Cl2N5O6S/c1-24-22-25(2)38-33-26(24)8-7-9-29(33)48-23-27-28(36)11-12-30(32(27)37)49(45,46)39-35(13-20-47-21-14-35)34(44)42-18-16-41(17-19-42)31(43)10-5-6-15-40(3)4/h7-9,11-12,22,39H,5-6,10,13-21,23H2,1-4H3
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n/an/an/a 0.437n/an/an/an/an/a



Menarini Ricerche

Curated by ChEMBL


Assay Description
Antagonist activity at human bradykinin B2 receptor expressed in dhfr-deficient CHO cells assessed as inhibition of bradykinin-induced inositol monop...


Bioorg Med Chem 20: 2091-100 (2012)


Article DOI: 10.1016/j.bmc.2012.01.036
BindingDB Entry DOI: 10.7270/Q2PN96WX
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50419906
PNG
(CHEMBL1956854)
Show SMILES Cc1cc(C)c2cccc(OCc3c(Cl)ccc(c3Cl)S(=O)(=O)NC3(CCOCC3)C(=O)N3CCN(CC3)C(=O)CCCCN)c2n1
Show InChI InChI=1S/C33H41Cl2N5O6S/c1-22-20-23(2)37-31-24(22)6-5-7-27(31)46-21-25-26(34)9-10-28(30(25)35)47(43,44)38-33(11-18-45-19-12-33)32(42)40-16-14-39(15-17-40)29(41)8-3-4-13-36/h5-7,9-10,20,38H,3-4,8,11-19,21,36H2,1-2H3
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n/an/an/a 0.479n/an/an/an/an/a



Menarini Ricerche

Curated by ChEMBL


Assay Description
Antagonist activity at human bradykinin B2 receptor expressed in dhfr-deficient CHO cells assessed as inhibition of bradykinin-induced inositol monop...


Bioorg Med Chem 20: 2091-100 (2012)


Article DOI: 10.1016/j.bmc.2012.01.036
BindingDB Entry DOI: 10.7270/Q2PN96WX
More data for this
Ligand-Target Pair
BDKRB2


(RAT)
BDBM50408045
PNG
(CHEMBL2372278)
Show SMILES NC(=N)NCCCCC(=O)N1CCC[C@@H]1C(=O)N1C[C@@H](O)C[C@@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N(CC(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C1CCCCC1
Show InChI InChI=1S/C52H76N14O12S/c53-51(54)57-19-7-6-18-44(71)63-21-9-17-39(63)48(75)66-28-34(68)24-40(66)46(73)59-26-42(69)61-37(25-35-15-10-22-79-35)45(72)62-38(30-67)47(74)65-27-32-12-5-4-11-31(32)23-41(65)49(76)64(33-13-2-1-3-14-33)29-43(70)60-36(50(77)78)16-8-20-58-52(55)56/h4-5,10-12,15,22,33-34,36-41,67-68H,1-3,6-9,13-14,16-21,23-30H2,(H,59,73)(H,60,70)(H,61,69)(H,62,72)(H,77,78)(H4,53,54,57)(H4,55,56,58)/t34-,36-,37-,38-,39+,40+,41+/m0/s1
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n/an/an/a 0.490n/an/an/an/an/a



Cortech, Inc.

Curated by ChEMBL


Assay Description
In vitro Bradykinin receptor B2 antagonist activity by using rat uterus functional assay


J Med Chem 39: 1472-84 (1996)


Article DOI: 10.1021/jm950716i
BindingDB Entry DOI: 10.7270/Q2HQ413S
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50411257
PNG
(CHEMBL373459)
Show SMILES Cc1cc(C)c2cccc(OCc3c(Cl)ccc(c3Cl)S(=O)(=O)NC3(CCCC3)C(=O)N3CCN(CC3)C(=O)[C@H](CCCN)[N+](C)(C)C)c2n1
Show InChI InChI=1S/C36H49Cl2N6O5S/c1-24-22-25(2)40-33-26(24)10-8-12-30(33)49-23-27-28(37)13-14-31(32(27)38)50(47,48)41-36(15-6-7-16-36)35(46)43-20-18-42(19-21-43)34(45)29(11-9-17-39)44(3,4)5/h8,10,12-14,22,29,41H,6-7,9,11,15-21,23,39H2,1-5H3/q+1/t29-/m0/s1
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n/an/an/a 0.501n/an/an/an/an/a



Menarini Ricerche

Curated by ChEMBL


Assay Description
Antagonist potency at human bradykinin B2 receptor assessed as effect on inositol monophosphate accumulation in CHOdhfr- cells


J Med Chem 50: 550-65 (2007)


Article DOI: 10.1021/jm061143k
BindingDB Entry DOI: 10.7270/Q2H13374
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50411265
PNG
(CHEMBL375576)
Show SMILES Cc1cc(C)c2cccc(OCc3c(Cl)ccc(c3Cl)S(=O)(=O)NC3(CCCC3)C(=O)N3CCN(CC3)C(=O)C[C@@H](N)CCCN)c2n1
Show InChI InChI=1S/C34H44Cl2N6O5S/c1-22-19-23(2)39-32-25(22)8-5-9-28(32)47-21-26-27(35)10-11-29(31(26)36)48(45,46)40-34(12-3-4-13-34)33(44)42-17-15-41(16-18-42)30(43)20-24(38)7-6-14-37/h5,8-11,19,24,40H,3-4,6-7,12-18,20-21,37-38H2,1-2H3/t24-/m0/s1
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n/an/an/a 0.501n/an/an/an/an/a



Menarini Ricerche

Curated by ChEMBL


Assay Description
Antagonist potency at human bradykinin B2 receptor assessed as effect on inositol monophosphate accumulation in CHOdhfr- cells


J Med Chem 50: 550-65 (2007)


Article DOI: 10.1021/jm061143k
BindingDB Entry DOI: 10.7270/Q2H13374
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50411247
PNG
(CHEMBL249235)
Show SMILES CN(C)CCCNC(=N)N1CCN(CC1)C(=O)C1(CCCC1)NS(=O)(=O)c1ccc(Cl)c(COc2cccc3c(C)cc(C)nc23)c1Cl
Show InChI InChI=1S/C34H45Cl2N7O4S/c1-23-21-24(2)39-31-25(23)9-7-10-28(31)47-22-26-27(35)11-12-29(30(26)36)48(45,46)40-34(13-5-6-14-34)32(44)42-17-19-43(20-18-42)33(37)38-15-8-16-41(3)4/h7,9-12,21,40H,5-6,8,13-20,22H2,1-4H3,(H2,37,38)
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n/an/an/a 0.501n/an/an/an/an/a



Menarini Ricerche

Curated by ChEMBL


Assay Description
Antagonist potency at human bradykinin B2 receptor assessed as effect on inositol monophosphate accumulation in CHOdhfr- cells


J Med Chem 50: 550-65 (2007)


Article DOI: 10.1021/jm061143k
BindingDB Entry DOI: 10.7270/Q2H13374
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50411258
PNG
(CHEMBL221285)
Show SMILES Cc1cc(C)c2cccc(OCc3c(Cl)ccc(c3Cl)S(=O)(=O)NC3(CCCC3)C(=O)N3CCN(CC3)C(=O)[C@H](CCCCN=C(N)N)[N+](C)(C)C)c2n1
Show InChI InChI=1S/C38H53Cl2N8O5S/c1-25-23-26(2)44-34-27(25)11-10-13-31(34)53-24-28-29(39)14-15-32(33(28)40)54(51,52)45-38(16-7-8-17-38)36(50)47-21-19-46(20-22-47)35(49)30(48(3,4)5)12-6-9-18-43-37(41)42/h10-11,13-15,23,30,45H,6-9,12,16-22,24H2,1-5H3,(H4,41,42,43)/q+1/t30-/m0/s1
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n/an/an/a 0.631n/an/an/an/an/a



Menarini Ricerche

Curated by ChEMBL


Assay Description
Antagonist potency at human bradykinin B2 receptor assessed as effect on inositol monophosphate accumulation in CHOdhfr- cells


J Med Chem 50: 550-65 (2007)


Article DOI: 10.1021/jm061143k
BindingDB Entry DOI: 10.7270/Q2H13374
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50419907
PNG
(CHEMBL1956855)
Show SMILES Cc1cc(C)c2cccc(OCc3c(Cl)ccc(c3Cl)S(=O)(=O)NC3(CCOCC3)C(=O)N3CCN(CC3)C(=O)[C@@H](N)CCCN)c2n1
Show InChI InChI=1S/C33H42Cl2N6O6S/c1-21-19-22(2)38-30-23(21)5-3-7-27(30)47-20-24-25(34)8-9-28(29(24)35)48(44,45)39-33(10-17-46-18-11-33)32(43)41-15-13-40(14-16-41)31(42)26(37)6-4-12-36/h3,5,7-9,19,26,39H,4,6,10-18,20,36-37H2,1-2H3/t26-/m0/s1
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n/an/an/a 0.724n/an/an/an/an/a



Menarini Ricerche

Curated by ChEMBL


Assay Description
Antagonist activity at human bradykinin B2 receptor expressed in dhfr-deficient CHO cells assessed as inhibition of bradykinin-induced inositol monop...


Bioorg Med Chem 20: 2091-100 (2012)


Article DOI: 10.1016/j.bmc.2012.01.036
BindingDB Entry DOI: 10.7270/Q2PN96WX
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50410917
PNG
(CHEMBL380273 | MEN-15442)
Show SMILES CN(C)CCC[C@H](N)C(=O)N1CCN(CC1)C(=O)C(C)(C)NS(=O)(=O)c1ccc(Cl)c(COc2cccc3c(C)cc(C)nc23)c1Cl
Show InChI InChI=1S/C33H44Cl2N6O5S/c1-21-19-22(2)37-30-23(21)9-7-11-27(30)46-20-24-25(34)12-13-28(29(24)35)47(44,45)38-33(3,4)32(43)41-17-15-40(16-18-41)31(42)26(36)10-8-14-39(5)6/h7,9,11-13,19,26,38H,8,10,14-18,20,36H2,1-6H3/t26-/m0/s1
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n/an/an/a 0.794n/an/an/an/an/a



Menarini Ricerche

Curated by ChEMBL


Assay Description
Activity at human B2 receptor transfected in CHO cells assessed as ability to antagonize BK-induced inositol-phosphate accumulation


J Med Chem 49: 3602-13 (2006)


Article DOI: 10.1021/jm060137l
BindingDB Entry DOI: 10.7270/Q2057H5F
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50419901
PNG
(CHEMBL1956720)
Show SMILES Cc1cc(C)c2cccc(OCc3c(Cl)ccc(c3Cl)S(=O)(=O)NC3(CCOCC3)C(=O)N3CCN(CC3)C(=O)C[N+](C)(C)C)c2n1
Show InChI InChI=1S/C33H42Cl2N5O6S/c1-22-19-23(2)36-31-24(22)7-6-8-27(31)46-21-25-26(34)9-10-28(30(25)35)47(43,44)37-33(11-17-45-18-12-33)32(42)39-15-13-38(14-16-39)29(41)20-40(3,4)5/h6-10,19,37H,11-18,20-21H2,1-5H3/q+1
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n/an/an/a 0.794n/an/an/an/an/a



Menarini Ricerche

Curated by ChEMBL


Assay Description
Antagonist activity at human bradykinin B2 receptor expressed in dhfr-deficient CHO cells assessed as inhibition of bradykinin-induced inositol monop...


Bioorg Med Chem 20: 2091-100 (2012)


Article DOI: 10.1016/j.bmc.2012.01.036
BindingDB Entry DOI: 10.7270/Q2PN96WX
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50411263
PNG
(CHEMBL267493)
Show SMILES Cc1cc(C)c2cccc(OCc3c(Cl)ccc(c3Cl)S(=O)(=O)NC3(CCCC3)C(=O)N3CCN(CC3)C(=O)C[C@@H](N)CCCN=C(N)N)c2n1
Show InChI InChI=1S/C35H46Cl2N8O5S/c1-22-19-23(2)42-32-25(22)8-5-9-28(32)50-21-26-27(36)10-11-29(31(26)37)51(48,49)43-35(12-3-4-13-35)33(47)45-17-15-44(16-18-45)30(46)20-24(38)7-6-14-41-34(39)40/h5,8-11,19,24,43H,3-4,6-7,12-18,20-21,38H2,1-2H3,(H4,39,40,41)/t24-/m0/s1
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n/an/an/a 0.794n/an/an/an/an/a



Menarini Ricerche

Curated by ChEMBL


Assay Description
Antagonist potency at human bradykinin B2 receptor assessed as effect on inositol monophosphate accumulation in CHOdhfr- cells


J Med Chem 50: 550-65 (2007)


Article DOI: 10.1021/jm061143k
BindingDB Entry DOI: 10.7270/Q2H13374
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50410917
PNG
(CHEMBL380273 | MEN-15442)
Show SMILES CN(C)CCC[C@H](N)C(=O)N1CCN(CC1)C(=O)C(C)(C)NS(=O)(=O)c1ccc(Cl)c(COc2cccc3c(C)cc(C)nc23)c1Cl
Show InChI InChI=1S/C33H44Cl2N6O5S/c1-21-19-22(2)37-30-23(21)9-7-11-27(30)46-20-24-25(34)12-13-28(29(24)35)47(44,45)38-33(3,4)32(43)41-17-15-40(16-18-41)31(42)26(36)10-8-14-39(5)6/h7,9,11-13,19,26,38H,8,10,14-18,20,36H2,1-6H3/t26-/m0/s1
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n/an/an/a 0.794n/an/an/an/an/a



Menarini Ricerche

Curated by ChEMBL


Assay Description
Antagonist potency at human bradykinin B2 receptor assessed as effect on inositol monophosphate accumulation in CHOdhfr- cells


J Med Chem 50: 550-65 (2007)


Article DOI: 10.1021/jm061143k
BindingDB Entry DOI: 10.7270/Q2H13374
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50419903
PNG
(CHEMBL1956723)
Show SMILES Cc1cc(C)c2cccc(OCc3c(Cl)ccc(c3Cl)S(=O)(=O)NC3(CCOCC3)C(=O)N3CCN(CC3)C(=O)CCCCC[N+](C)(C)C)c2n1
Show InChI InChI=1S/C37H50Cl2N5O6S/c1-26-24-27(2)40-35-28(26)10-9-11-31(35)50-25-29-30(38)13-14-32(34(29)39)51(47,48)41-37(15-22-49-23-16-37)36(46)43-19-17-42(18-20-43)33(45)12-7-6-8-21-44(3,4)5/h9-11,13-14,24,41H,6-8,12,15-23,25H2,1-5H3/q+1
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n/an/an/a 0.794n/an/an/an/an/a



Menarini Ricerche

Curated by ChEMBL


Assay Description
Antagonist activity at human bradykinin B2 receptor expressed in dhfr-deficient CHO cells assessed as inhibition of bradykinin-induced inositol monop...


Bioorg Med Chem 20: 2091-100 (2012)


Article DOI: 10.1016/j.bmc.2012.01.036
BindingDB Entry DOI: 10.7270/Q2PN96WX
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50411261
PNG
(CHEMBL375820)
Show SMILES Cc1cc(C)c2cccc(OCc3c(Cl)ccc(c3Cl)S(=O)(=O)NC(C)(C)C(=O)N3CCN(CC3)C(=O)[C@@H](N)CCCCN=C(N)N)c2n1
Show InChI InChI=1S/C33H44Cl2N8O5S/c1-20-18-21(2)40-29-22(20)8-7-10-26(29)48-19-23-24(34)11-12-27(28(23)35)49(46,47)41-33(3,4)31(45)43-16-14-42(15-17-43)30(44)25(36)9-5-6-13-39-32(37)38/h7-8,10-12,18,25,41H,5-6,9,13-17,19,36H2,1-4H3,(H4,37,38,39)/t25-/m0/s1
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n/an/an/a 0.794n/an/an/an/an/a



Menarini Ricerche

Curated by ChEMBL


Assay Description
Antagonist potency at human bradykinin B2 receptor assessed as effect on inositol monophosphate accumulation in CHOdhfr- cells


J Med Chem 50: 550-65 (2007)


Article DOI: 10.1021/jm061143k
BindingDB Entry DOI: 10.7270/Q2H13374
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50419919
PNG
(CHEMBL1956721)
Show SMILES Cc1cc(C)c2cccc(OCc3c(Cl)ccc(c3Cl)S(=O)(=O)NC3(CCOCC3)C(=O)N3CCN(CC3)C(=O)CCC[N+](C)(C)C)c2n1
Show InChI InChI=1S/C35H46Cl2N5O6S/c1-24-22-25(2)38-33-26(24)8-6-9-29(33)48-23-27-28(36)11-12-30(32(27)37)49(45,46)39-35(13-20-47-21-14-35)34(44)41-17-15-40(16-18-41)31(43)10-7-19-42(3,4)5/h6,8-9,11-12,22,39H,7,10,13-21,23H2,1-5H3/q+1
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n/an/an/a 0.794n/an/an/an/an/a



Menarini Ricerche

Curated by ChEMBL


Assay Description
Antagonist activity at human bradykinin B2 receptor expressed in dhfr-deficient CHO cells assessed as inhibition of bradykinin-induced inositol monop...


Bioorg Med Chem 20: 2091-100 (2012)


Article DOI: 10.1016/j.bmc.2012.01.036
BindingDB Entry DOI: 10.7270/Q2PN96WX
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50419922
PNG
(CHEMBL1956870)
Show SMILES Cc1cc(C)c2cccc(OCc3c(Cl)ccc(c3Cl)S(=O)(=O)NC3(CCOCC3)C(=O)N3CCN(CCCCCC[N+](C)(C)C)CC3)c2n1
Show InChI InChI=1S/C37H52Cl2N5O5S/c1-27-25-28(2)40-35-29(27)11-10-12-32(35)49-26-30-31(38)13-14-33(34(30)39)50(46,47)41-37(15-23-48-24-16-37)36(45)43-20-18-42(19-21-43)17-8-6-7-9-22-44(3,4)5/h10-14,25,41H,6-9,15-24,26H2,1-5H3/q+1
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n/an/an/a 0.794n/an/an/an/an/a



Menarini Ricerche

Curated by ChEMBL


Assay Description
Antagonist activity at human bradykinin B2 receptor expressed in dhfr-deficient CHO cells assessed as inhibition of bradykinin-induced inositol monop...


Bioorg Med Chem 20: 2091-100 (2012)


Article DOI: 10.1016/j.bmc.2012.01.036
BindingDB Entry DOI: 10.7270/Q2PN96WX
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50411250
PNG
(CHEMBL220595)
Show SMILES CN(C)CCCC[C@H](N)C(=O)N1CCN(CC1)C(=O)C1(CCCC1)NS(=O)(=O)c1ccc(Cl)c(COc2cccc3c(C)cc(C)nc23)c1Cl
Show InChI InChI=1S/C36H48Cl2N6O5S/c1-24-22-25(2)40-33-26(24)10-9-12-30(33)49-23-27-28(37)13-14-31(32(27)38)50(47,48)41-36(15-6-7-16-36)35(46)44-20-18-43(19-21-44)34(45)29(39)11-5-8-17-42(3)4/h9-10,12-14,22,29,41H,5-8,11,15-21,23,39H2,1-4H3/t29-/m0/s1
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n/an/an/a 0.794n/an/an/an/an/a



Menarini Ricerche

Curated by ChEMBL


Assay Description
Antagonist potency at human bradykinin B2 receptor assessed as effect on inositol monophosphate accumulation in CHOdhfr- cells


J Med Chem 50: 550-65 (2007)


Article DOI: 10.1021/jm061143k
BindingDB Entry DOI: 10.7270/Q2H13374
More data for this
Ligand-Target Pair
BDKRB2


(RAT)
BDBM50408048
PNG
(CHEMBL3038099)
Show SMILES N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N(CC(=O)N[C@@H](CCCN=C(N)N)C(O)=O)C1CCCCC1
Show InChI InChI=1S/C58H89N19O13S/c59-38(16-6-20-66-56(60)61)48(82)72-39(17-7-21-67-57(62)63)51(85)74-23-9-19-43(74)53(87)77-30-36(79)26-44(77)50(84)69-28-46(80)71-41(27-37-15-10-24-91-37)49(83)73-42(32-78)52(86)76-29-34-12-5-4-11-33(34)25-45(76)54(88)75(35-13-2-1-3-14-35)31-47(81)70-40(55(89)90)18-8-22-68-58(64)65/h4-5,10-12,15,24,35-36,38-45,78-79H,1-3,6-9,13-14,16-23,25-32,59H2,(H,69,84)(H,70,81)(H,71,80)(H,72,82)(H,73,83)(H,89,90)(H4,60,61,66)(H4,62,63,67)(H4,64,65,68)/t36-,38+,39+,40+,41+,42+,43+,44+,45-/m1/s1
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n/an/an/a 0.813n/an/an/an/an/a



Cortech, Inc.

Curated by ChEMBL


Assay Description
In vitro Bradykinin receptor B2 antagonist activity by using rat uterus functional assay


J Med Chem 39: 1472-84 (1996)


Article DOI: 10.1021/jm950716i
BindingDB Entry DOI: 10.7270/Q2HQ413S
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50403371
PNG
(Firazyr | HOE-140 | ICATIBANT)
Show SMILES N[C@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N1[C@H]2CCCC[C@H]2C[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(O)=O
Show InChI InChI=1S/C59H89N19O13S/c60-37(14-5-19-67-57(61)62)48(82)72-38(15-6-20-68-58(63)64)52(86)75-22-8-18-43(75)54(88)77-30-35(80)26-44(77)50(84)70-28-47(81)71-40(27-36-13-9-23-92-36)49(83)74-41(31-79)53(87)76-29-34-12-2-1-10-32(34)24-46(76)55(89)78-42-17-4-3-11-33(42)25-45(78)51(85)73-39(56(90)91)16-7-21-69-59(65)66/h1-2,9-10,12-13,23,33,35,37-46,79-80H,3-8,11,14-22,24-31,60H2,(H,70,84)(H,71,81)(H,72,82)(H,73,85)(H,74,83)(H,90,91)(H4,61,62,67)(H4,63,64,68)(H4,65,66,69)/t33-,35+,37+,38-,39-,40-,41-,42-,43-,44-,45-,46+/m0/s1
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n/an/an/a 0.912n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonist effect against bradykinin B2 receptor was determined in rabbit jugular vein


Bioorg Med Chem Lett 4: 781-784 (1994)


Article DOI: 10.1016/S0960-894X(01)80847-7
BindingDB Entry DOI: 10.7270/Q2NP25KV
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50419912
PNG
(CHEMBL1956861)
Show SMILES Cc1cc(C)c2cccc(OCc3c(Cl)ccc(c3Cl)S(=O)(=O)NC3(CCOCC3)C(=O)N3CC[N+](C)(CCC[N+](C)(C)C)CC3)c2n1
Show InChI InChI=1S/C35H49Cl2N5O5S/c1-25-23-26(2)38-33-27(25)9-7-10-30(33)47-24-28-29(36)11-12-31(32(28)37)48(44,45)39-35(13-21-46-22-14-35)34(43)40-15-19-42(6,20-16-40)18-8-17-41(3,4)5/h7,9-12,23,39H,8,13-22,24H2,1-6H3/q+2
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n/an/an/a 1n/an/an/an/an/a



Menarini Ricerche

Curated by ChEMBL


Assay Description
Antagonist activity at human bradykinin B2 receptor expressed in dhfr-deficient CHO cells assessed as inhibition of bradykinin-induced inositol monop...


Bioorg Med Chem 20: 2091-100 (2012)


Article DOI: 10.1016/j.bmc.2012.01.036
BindingDB Entry DOI: 10.7270/Q2PN96WX
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50411259
PNG
(CHEMBL374273)
Show SMILES Cc1cc(C)c2cccc(OCc3c(Cl)ccc(c3Cl)S(=O)(=O)NC3(CCCC3)C(=O)N3CCN(CC3)C(=O)[C@@H](N)CCCC[N+](C)(C)C)c2n1
Show InChI InChI=1S/C37H51Cl2N6O5S/c1-25-23-26(2)41-34-27(25)11-10-13-31(34)50-24-28-29(38)14-15-32(33(28)39)51(48,49)42-37(16-7-8-17-37)36(47)44-20-18-43(19-21-44)35(46)30(40)12-6-9-22-45(3,4)5/h10-11,13-15,23,30,42H,6-9,12,16-22,24,40H2,1-5H3/q+1/t30-/m0/s1
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n/an/an/a 1.26n/an/an/an/an/a



Menarini Ricerche

Curated by ChEMBL


Assay Description
Antagonist potency at human bradykinin B2 receptor assessed as effect on inositol monophosphate accumulation in CHOdhfr- cells


J Med Chem 50: 550-65 (2007)


Article DOI: 10.1021/jm061143k
BindingDB Entry DOI: 10.7270/Q2H13374
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50411254
PNG
(CHEMBL218636)
Show SMILES CC(=O)N1CCC(CC1)(NS(=O)(=O)c1ccc(Cl)c(COc2cccc3c(C)cc(C)nc23)c1Cl)C(=O)N1CCN(CC1)C(=O)[C@@H](N)CCC[N+](C)(C)C
Show InChI InChI=1S/C38H52Cl2N7O6S/c1-25-23-26(2)42-35-28(25)9-7-11-32(35)53-24-29-30(39)12-13-33(34(29)40)54(51,52)43-38(14-16-44(17-15-38)27(3)48)37(50)46-20-18-45(19-21-46)36(49)31(41)10-8-22-47(4,5)6/h7,9,11-13,23,31,43H,8,10,14-22,24,41H2,1-6H3/q+1/t31-/m0/s1
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n/an/an/a 1.26n/an/an/an/an/a



Menarini Ricerche

Curated by ChEMBL


Assay Description
Antagonist potency at human bradykinin B2 receptor assessed as effect on inositol monophosphate accumulation in CHOdhfr- cells


J Med Chem 50: 550-65 (2007)


Article DOI: 10.1021/jm061143k
BindingDB Entry DOI: 10.7270/Q2H13374
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50419904
PNG
(CHEMBL1956852)
Show SMILES Cc1cc(C)c2cccc(OCc3c(Cl)ccc(c3Cl)S(=O)(=O)NC3(CCOCC3)C(=O)N3CCN(CC3)C(=O)CCCCCC[N+](C)(C)C)c2n1
Show InChI InChI=1S/C38H52Cl2N5O6S/c1-27-25-28(2)41-36-29(27)11-10-12-32(36)51-26-30-31(39)14-15-33(35(30)40)52(48,49)42-38(16-23-50-24-17-38)37(47)44-20-18-43(19-21-44)34(46)13-8-6-7-9-22-45(3,4)5/h10-12,14-15,25,42H,6-9,13,16-24,26H2,1-5H3/q+1
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n/an/an/a 1.26n/an/an/an/an/a



Menarini Ricerche

Curated by ChEMBL


Assay Description
Antagonist activity at human bradykinin B2 receptor expressed in dhfr-deficient CHO cells assessed as inhibition of bradykinin-induced inositol monop...


Bioorg Med Chem 20: 2091-100 (2012)


Article DOI: 10.1016/j.bmc.2012.01.036
BindingDB Entry DOI: 10.7270/Q2PN96WX
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50411246
PNG
(CHEMBL220478)
Show SMILES Cc1cc(C)c2cccc(OCc3c(Cl)ccc(c3Cl)S(=O)(=O)NC3(CCCC3)C(=O)N3CCN(CC3)C(=O)C[C@H](CCCN)[N+](C)(C)C)c2n1
Show InChI InChI=1S/C37H51Cl2N6O5S/c1-25-22-26(2)41-35-28(25)11-8-12-31(35)50-24-29-30(38)13-14-32(34(29)39)51(48,49)42-37(15-6-7-16-37)36(47)44-20-18-43(19-21-44)33(46)23-27(10-9-17-40)45(3,4)5/h8,11-14,22,27,42H,6-7,9-10,15-21,23-24,40H2,1-5H3/q+1/t27-/m0/s1
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n/an/an/a 1.26n/an/an/an/an/a



Menarini Ricerche

Curated by ChEMBL


Assay Description
Antagonist potency at human bradykinin B2 receptor assessed as effect on inositol monophosphate accumulation in CHOdhfr- cells


J Med Chem 50: 550-65 (2007)


Article DOI: 10.1021/jm061143k
BindingDB Entry DOI: 10.7270/Q2H13374
More data for this
Ligand-Target Pair
BDKRB2


(RAT)
BDBM50408051
PNG
(CHEMBL3038095)
Show SMILES N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N(CC(=O)N[C@@H](CCCN=C(N)N)C(O)=O)c1ccccc1
Show InChI InChI=1S/C58H83N19O13S/c59-38(16-6-20-66-56(60)61)48(82)72-39(17-7-21-67-57(62)63)51(85)74-23-9-19-43(74)53(87)77-30-36(79)26-44(77)50(84)69-28-46(80)71-41(27-37-15-10-24-91-37)49(83)73-42(32-78)52(86)76-29-34-12-5-4-11-33(34)25-45(76)54(88)75(35-13-2-1-3-14-35)31-47(81)70-40(55(89)90)18-8-22-68-58(64)65/h1-5,10-15,24,36,38-45,78-79H,6-9,16-23,25-32,59H2,(H,69,84)(H,70,81)(H,71,80)(H,72,82)(H,73,83)(H,89,90)(H4,60,61,66)(H4,62,63,67)(H4,64,65,68)/t36-,38+,39+,40+,41+,42+,43+,44+,45-/m1/s1
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n/an/an/a 1.32n/an/an/an/an/a



Cortech, Inc.

Curated by ChEMBL


Assay Description
In vitro Bradykinin receptor B2 antagonist activity by using rat uterus functional assay


J Med Chem 39: 1472-84 (1996)


Article DOI: 10.1021/jm950716i
BindingDB Entry DOI: 10.7270/Q2HQ413S
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50036833
PNG
(CHEMBL2371961 | D-Arg-Arg-Pro-Hyp-Gly-Phe-Ser-D-Ti...)
Show SMILES N[C@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N1CCc2ccccc2[C@@H]1C(=O)N1C[C@H](C2CCCCC12)C(=O)N[C@@H](CCCN=C(N)N)C(O)=O
Show InChI InChI=1S/C61H91N19O13/c62-40(17-8-23-69-59(63)64)51(85)74-41(18-9-24-70-60(65)66)54(88)77-26-11-21-46(77)56(90)79-31-36(82)29-47(79)53(87)72-30-48(83)73-43(28-34-12-2-1-3-13-34)52(86)76-44(33-81)55(89)78-27-22-35-14-4-5-15-37(35)49(78)57(91)80-32-39(38-16-6-7-20-45(38)80)50(84)75-42(58(92)93)19-10-25-71-61(67)68/h1-5,12-15,36,38-47,49,81-82H,6-11,16-33,62H2,(H,72,87)(H,73,83)(H,74,85)(H,75,84)(H,76,86)(H,92,93)(H4,63,64,69)(H4,65,66,70)(H4,67,68,71)/t36-,38?,39-,40-,41+,42+,43+,44+,45?,46+,47+,49-/m1/s1
MMDB

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n/an/an/a 1.5n/an/an/an/an/a



Scios Nova Inc.

Curated by ChEMBL


Assay Description
Antagonism against bradykinin receptor B2 in guinea pig ileal tissue


J Med Chem 36: 2569-71 (1993)


Article DOI: 10.1021/jm00069a016
BindingDB Entry DOI: 10.7270/Q25D8QX4
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50411274
PNG
(CHEMBL220596)
Show SMILES CN(C)CCC[C@H](N)CC(=O)N1CCN(CC1)C(=O)C1(CCCC1)NS(=O)(=O)c1ccc(Cl)c(COc2cccc3c(C)cc(C)nc23)c1Cl
Show InChI InChI=1S/C36H48Cl2N6O5S/c1-24-21-25(2)40-34-27(24)10-7-11-30(34)49-23-28-29(37)12-13-31(33(28)38)50(47,48)41-36(14-5-6-15-36)35(46)44-19-17-43(18-20-44)32(45)22-26(39)9-8-16-42(3)4/h7,10-13,21,26,41H,5-6,8-9,14-20,22-23,39H2,1-4H3/t26-/m0/s1
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n/an/an/a 1.58n/an/an/an/an/a



Menarini Ricerche

Curated by ChEMBL


Assay Description
Antagonist potency at human bradykinin B2 receptor assessed as effect on inositol monophosphate accumulation in CHOdhfr- cells


J Med Chem 50: 550-65 (2007)


Article DOI: 10.1021/jm061143k
BindingDB Entry DOI: 10.7270/Q2H13374
More data for this
Ligand-Target Pair
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