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Compile Data Set for Download or QSAR

Found 120 hits Enz. Inhib. hit(s) with Target = 'Bromodomain adjacent to zinc finger domain protein 2B'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Bromodomain adjacent to zinc finger domain protein 2B


(Homo sapiens (Human))
BDBM50148270
PNG
(CHEMBL3739699)
Show SMILES CCCOc1ccn2c(cc(-c3ccccc3S(C)(=O)=O)c2c1)C(C)=O
Show InChI InChI=1S/C20H21NO4S/c1-4-11-25-15-9-10-21-18(14(2)22)13-17(19(21)12-15)16-7-5-6-8-20(16)26(3,23)24/h5-10,12-13H,4,11H2,1-3H3
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n/an/an/a 60n/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Binding affinity to biotinylated C-terminal Avi/His-TEV-tagged BAZ2B (unknown origin) expressed in Escherichia coli by Biolayer Interferometric analy...


J Med Chem 59: 1410-24 (2016)


Article DOI: 10.1021/acs.jmedchem.5b00209
BindingDB Entry DOI: 10.7270/Q2PK0J09
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Bromodomain adjacent to zinc finger domain protein 2B


(Homo sapiens (Human))
BDBM50148270
PNG
(CHEMBL3739699)
Show SMILES CCCOc1ccn2c(cc(-c3ccccc3S(C)(=O)=O)c2c1)C(C)=O
Show InChI InChI=1S/C20H21NO4S/c1-4-11-25-15-9-10-21-18(14(2)22)13-17(19(21)12-15)16-7-5-6-8-20(16)26(3,23)24/h5-10,12-13H,4,11H2,1-3H3
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n/an/an/a 136n/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Binding affinity to recombinant His6-TEV fused human BAZ2B expressed in Escherichia coli by isothermal titration calorimetric analysis


J Med Chem 59: 1410-24 (2016)


Article DOI: 10.1021/acs.jmedchem.5b00209
BindingDB Entry DOI: 10.7270/Q2PK0J09
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Bromodomain adjacent to zinc finger domain protein 2B


(Homo sapiens (Human))
BDBM50078633
PNG
(CHEMBL3415187)
Show SMILES Cn1cc(Cn2cnc(-c3cnn(C)c3)c2-c2ccc(cc2)C#N)cn1
Show InChI InChI=1S/C19H17N7/c1-24-10-15(8-22-24)11-26-13-21-18(17-9-23-25(2)12-17)19(26)16-5-3-14(7-20)4-6-16/h3-6,8-10,12-13H,11H2,1-2H3
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n/an/an/a 170n/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Binding affinity to BAZ2B (unknown origin) by isothermal titration calorimetric analysis


J Med Chem 58: 2553-9 (2015)


Article DOI: 10.1021/jm501963e
BindingDB Entry DOI: 10.7270/Q2V69M9B
More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2B


(Homo sapiens (Human))
BDBM50150818
PNG
(CHEMBL3774575)
Show SMILES CCCOc1cc(OCCCCN(C)C)cc(Oc2cc3n(C)c(=O)n(C)c3cc2NS(=O)(=O)c2ccc(OC)c(OC)c2)c1
Show InChI InChI=1S/C32H42N4O8S/c1-8-14-42-22-16-23(43-15-10-9-13-34(2)3)18-24(17-22)44-30-21-28-27(35(4)32(37)36(28)5)20-26(30)33-45(38,39)25-11-12-29(40-6)31(19-25)41-7/h11-12,16-21,33H,8-10,13-15H2,1-7H3
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n/an/an/a 400n/an/an/an/an/a



The University of Texas M.D. Anderson Cancer Center

Curated by ChEMBL


Assay Description
Inhibition of KDM6B (unknown origin) using biotin-H3K27me3 (21 to 44 residues) as substrate preincubated for 15 mins followed by substrate addition m...


J Med Chem 59: 1440-54 (2016)


Article DOI: 10.1021/acs.jmedchem.5b00405
BindingDB Entry DOI: 10.7270/Q26975F4
More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2B


(Homo sapiens (Human))
BDBM220447
PNG
(US9296741, 36)
Show SMILES CCS(=O)(=O)Nc1ccc(Oc2ccc(F)cc2F)c(c1)-c1cn(C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C22H19F2N3O4S/c1-3-32(29,30)26-14-5-7-19(31-20-6-4-13(23)10-18(20)24)16(11-14)17-12-27(2)22(28)21-15(17)8-9-25-21/h4-12,25-26H,3H2,1-2H3
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n/an/an/a>1.00E+3n/an/an/an/an/a



AbbVie Inc

Curated by ChEMBL


Assay Description
Binding affinity to human BAZ2B (S2054 to S2168 residues) expressed in bacterial expression system by BROMOscan assay


J Med Chem 60: 8369-8384 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00746
BindingDB Entry DOI: 10.7270/Q2251MB8
More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2B


(Homo sapiens (Human))
BDBM50453949
PNG
(CHEMBL4208820)
Show SMILES CNC(=O)c1ccc(cn1)-c1cc2cccc(-c3nn(C4CCOCC4)c4CCN(Cc34)C(C)=O)c2cn1
Show InChI InChI=1S/C29H30N6O3/c1-18(36)34-11-8-27-24(17-34)28(33-35(27)21-9-12-38-13-10-21)22-5-3-4-19-14-26(32-16-23(19)22)20-6-7-25(31-15-20)29(37)30-2/h3-7,14-16,21H,8-13,17H2,1-2H3,(H,30,37)
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n/an/an/a 1.90E+3n/an/an/an/an/a



WuXi AppTec Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity to human partial length BAZ2B (S2054 to S2168 residues) expressed in bacterial expression system by BROMOscan assay


Bioorg Med Chem Lett 28: 15-23 (2018)

More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2B


(Homo sapiens (Human))
BDBM50148270
PNG
(CHEMBL3739699)
Show SMILES CCCOc1ccn2c(cc(-c3ccccc3S(C)(=O)=O)c2c1)C(C)=O
Show InChI InChI=1S/C20H21NO4S/c1-4-11-25-15-9-10-21-18(14(2)22)13-17(19(21)12-15)16-7-5-6-8-20(16)26(3,23)24/h5-10,12-13H,4,11H2,1-3H3
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n/an/an/a 3.16E+3n/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Binding affinity to BAZ2B in human HUT78 cell extract by chemoproteomic competition binding assay


J Med Chem 59: 1410-24 (2016)


Article DOI: 10.1021/acs.jmedchem.5b00209
BindingDB Entry DOI: 10.7270/Q2PK0J09
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Bromodomain adjacent to zinc finger domain protein 2B


(Homo sapiens (Human))
BDBM179481
PNG
(US9675697, Cpd. No. 73)
Show SMILES COc1cc2c(cc1-c1c(C)noc1C)[nH]c1nc(C)nc(-c3ccnc4ccccc34)c21
Show InChI InChI=1S/C26H21N5O2/c1-13-23(14(2)33-31-13)19-11-21-18(12-22(19)32-4)24-25(28-15(3)29-26(24)30-21)17-9-10-27-20-8-6-5-7-16(17)20/h5-12H,1-4H3,(H,28,29,30)
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n/an/an/a>4.00E+3n/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to human partial length BAZ2B (S2054 to S2168 residues) expressed in bacterial expression system by BROMOscan assay


J Med Chem 60: 3887-3901 (2017)

More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2B


(Homo sapiens (Human))
BDBM50366670
PNG
(CHEMBL4173488)
Show SMILES COc1cc2c(cc1-c1c(C)noc1C)[nH]c1nc(C)nc(Nc3cc(nn3C)C3CC3)c21
Show InChI InChI=1S/C24H25N7O2/c1-11-21(12(2)33-30-11)16-8-18-15(9-19(16)32-5)22-23(27-18)25-13(3)26-24(22)28-20-10-17(14-6-7-14)29-31(20)4/h8-10,14H,6-7H2,1-5H3,(H2,25,26,27,28)
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n/an/an/a>5.00E+3n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to human BAZ2B (S2054 to S2168 residues) expressed in bacterial expression system by BROMOScan assay


J Med Chem 61: 6110-6120 (2018)

More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2B


(Homo sapiens (Human))
BDBM50468912
PNG
(CHEMBL4284812)
Show SMILES Cc1cc2n(C)c(=O)n(C)c2cc1S(=O)(=O)NCc1ccc(F)cc1
Show InChI InChI=1S/C17H18FN3O3S/c1-11-8-14-15(21(3)17(22)20(14)2)9-16(11)25(23,24)19-10-12-4-6-13(18)7-5-12/h4-9,19H,10H2,1-3H3
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n/an/an/a 6.00E+3n/an/an/an/an/a



University of Z£rich

Curated by ChEMBL


Assay Description
Binding affinity to recombinant human BAZ2B (S2054 to S2168 residues) expressed in bacterial expression system by BROMOscan assay


Eur J Med Chem 156: 907-917 (2018)

More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2B


(Homo sapiens (Human))
BDBM50098305
PNG
(CHEMBL3590405)
Show SMILES Cc1cncc(c1)-c1ccc(N[C@@H]2CCNC[C@H]2OCC2CCS(=O)(=O)CC2)c2[nH]c(=O)c(C)cc12
Show InChI InChI=1/C27H34N4O4S/c1-17-11-20(14-29-13-17)21-3-4-24(26-22(21)12-18(2)27(32)31-26)30-23-5-8-28-15-25(23)35-16-19-6-9-36(33,34)10-7-19/h3-4,11-14,19,23,25,28,30H,5-10,15-16H2,1-2H3,(H,31,32)/t23-,25-/s2
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n/an/an/a 7.94E+3n/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Binding affinity to BAZ2B in human HUT78 cells incubated for 45 mins by mass spectrometry based bromosphere chemoproteomic assay


J Med Chem 58: 6151-78 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00773
BindingDB Entry DOI: 10.7270/Q2FN17Z1
More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2B


(Homo sapiens (Human))
BDBM50495365
PNG
(CHEMBL3110241)
Show SMILES CNC(=O)N1CCc2[nH]c3ccc(Cl)cc3c2C1
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n/an/an/a 8.00E+3n/an/an/an/an/a



University of Cambridge

Curated by ChEMBL


Assay Description
Binding affinity to human BAZ2B expressed in Escherichia coli BL21(DE3) by direct isothermal titration calorimetric analysis


J Med Chem 56: 10183-7 (2013)

More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2B


(Homo sapiens (Human))
BDBM50092310
PNG
(CHEMBL3581661 | US9675697, Cpd. No. 23)
Show SMILES COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ccnc(-c3c(C)[nH]nc3C3CC3)c21
Show InChI InChI=1S/C24H23N5O2/c1-11-21(23(28-27-11)14-5-6-14)24-22-15-10-19(30-4)16(20-12(2)29-31-13(20)3)9-18(15)26-17(22)7-8-25-24/h7-10,14,26H,5-6H2,1-4H3,(H,27,28)
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n/an/an/a>1.00E+4n/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to biotinylated BAZ2B (2054 to 2168 amino acid residues) (unknown origin) expressed in Rosetta2 DE3 cells by bio-layer interferometr...


J Med Chem 58: 4927-39 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00613
BindingDB Entry DOI: 10.7270/Q2XD13FK
More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2B


(Homo sapiens (Human))
BDBM50495361
PNG
(CHEMBL3110228)
Show SMILES CC(=O)N1CCc2[nH]c3ccc(Br)cc3c2C1
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n/an/an/a 1.00E+4n/an/an/an/an/a



University of Cambridge

Curated by ChEMBL


Assay Description
Binding affinity to human BAZ2B expressed in Escherichia coli BL21(DE3) by competitive isothermal titration calorimetric analysis


J Med Chem 56: 10183-7 (2013)

More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2B


(Homo sapiens (Human))
BDBM50495368
PNG
(CHEMBL3110242)
Show SMILES CNC(=O)N1CCc2[nH]c3ccc(Br)cc3c2C1
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n/an/an/a 1.70E+4n/an/an/an/an/a



University of Cambridge

Curated by ChEMBL


Assay Description
Binding affinity to human BAZ2B expressed in Escherichia coli BL21(DE3) by direct isothermal titration calorimetric analysis


J Med Chem 56: 10183-7 (2013)

More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2B


(Homo sapiens (Human))
BDBM50172115
PNG
(CHEMBL3810055)
Show SMILES CC(=O)N(c1cn(C(C)=O)c2ccccc12)c1cc(O)ccc1C
Show InChI InChI=1S/C19H18N2O3/c1-12-8-9-15(24)10-18(12)21(14(3)23)19-11-20(13(2)22)17-7-5-4-6-16(17)19/h4-11,24H,1-3H3
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n/an/an/a 2.30E+4n/an/an/an/an/a



University of Z£rich

Curated by ChEMBL


Assay Description
Competitive binding affinity to human His-tagged BRAZ2B (1858 to 1972 residues) expressed in T7 phage-infected Escherichia coli BL21(DE3) cells measu...


J Med Chem 59: 3087-97 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01757
BindingDB Entry DOI: 10.7270/Q2MP556R
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Bromodomain adjacent to zinc finger domain protein 2B


(Homo sapiens (Human))
BDBM50455480
PNG
(CHEMBL4218735)
Show SMILES CC(=O)N1[C@H](CN(Cc2ccccc2CO)c2cc(ccc12)C1=CCNCC1)C1CC1
Show InChI InChI=1S/C26H31N3O2/c1-18(31)29-24-9-8-21(19-10-12-27-13-11-19)14-25(24)28(16-26(29)20-6-7-20)15-22-4-2-3-5-23(22)17-30/h2-5,8-10,14,20,26-27,30H,6-7,11-13,15-17H2,1H3/t26-/m1/s1
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n/an/an/a<3.02E+4n/an/an/an/an/a



University of Strathclyde

Curated by ChEMBL


Assay Description
Binding affinity to human partial length DNA-tagged BAZ2B expressed in bacterial by BROMOscan method


J Med Chem 61: 4317-4334 (2018)

More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2B


(Homo sapiens (Human))
BDBM50172116
PNG
(CHEMBL3809983)
Show SMILES CC(=O)n1cc(N(C(=O)c2cccc(c2)C(F)(F)F)c2cc(O)ccc2C)c2ccccc12
Show InChI InChI=1S/C25H19F3N2O3/c1-15-10-11-19(32)13-22(15)30(24(33)17-6-5-7-18(12-17)25(26,27)28)23-14-29(16(2)31)21-9-4-3-8-20(21)23/h3-14,32H,1-2H3
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n/an/an/a 3.90E+4n/an/an/an/an/a



University of Z£rich

Curated by ChEMBL


Assay Description
Competitive binding affinity to human His-tagged BRAZ2B (1858 to 1972 residues) expressed in T7 phage-infected Escherichia coli BL21(DE3) cells measu...


J Med Chem 59: 3087-97 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01757
BindingDB Entry DOI: 10.7270/Q2MP556R
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Bromodomain adjacent to zinc finger domain protein 2B


(Homo sapiens (Human))
BDBM71168
PNG
(2-chloranyl-N-(1-ethanoylindol-3-yl)-N-phenyl-etha...)
Show SMILES CC(=O)n1cc(N(C(=O)CCl)c2ccccc2)c2ccccc12
Show InChI InChI=1S/C18H15ClN2O2/c1-13(22)20-12-17(15-9-5-6-10-16(15)20)21(18(23)11-19)14-7-3-2-4-8-14/h2-10,12H,11H2,1H3
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University of Z£rich

Curated by ChEMBL


Assay Description
Competitive binding affinity to human His-tagged BRAZ2B (1858 to 1972 residues) expressed in T7 phage-infected Escherichia coli BL21(DE3) cells measu...


J Med Chem 59: 3087-97 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01757
BindingDB Entry DOI: 10.7270/Q2MP556R
More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2B


(Homo sapiens (Human))
BDBM50277366
PNG
(CHEMBL4171398)
Show SMILES CCC(=O)c1c[nH]c(c1)C(=O)OC
Show InChI InChI=1S/C9H11NO3/c1-3-8(11)6-4-7(10-5-6)9(12)13-2/h4-5,10H,3H2,1-2H3
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n/an/an/a 5.40E+4n/an/an/an/an/a



University of Z£rich

Curated by ChEMBL


Assay Description
Binding affinity to human BAZ2B (S2054 to S2168 residues) expressed in bacterial expression system by BROMOscan assay


Eur J Med Chem 139: 564-572 (2017)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Bromodomain adjacent to zinc finger domain protein 2B


(Homo sapiens (Human))
BDBM50495371
PNG
(CHEMBL3110247)
Show SMILES CC(=O)N1CCc2[nH]c3ccc(Cl)cc3c2C1
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n/an/an/a 6.50E+4n/an/an/an/an/a



University of Cambridge

Curated by ChEMBL


Assay Description
Binding affinity to human BAZ2B expressed in Escherichia coli BL21(DE3) by competitive isothermal titration calorimetric analysis


J Med Chem 56: 10183-7 (2013)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Bromodomain adjacent to zinc finger domain protein 2B


(Homo sapiens (Human))
BDBM50277360
PNG
(CHEMBL4166955)
Show SMILES CCOC(=O)c1cn(C)c(=O)cc1Cl
Show InChI InChI=1S/C9H10ClNO3/c1-3-14-9(13)6-5-11(2)8(12)4-7(6)10/h4-5H,3H2,1-2H3
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n/an/an/a 8.70E+4n/an/an/an/an/a



University of Z£rich

Curated by ChEMBL


Assay Description
Binding affinity to human BAZ2B (S2054 to S2168 residues) expressed in bacterial expression system by BROMOscan assay


Eur J Med Chem 139: 564-572 (2017)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Bromodomain adjacent to zinc finger domain protein 2B


(Homo sapiens (Human))
BDBM50495363
PNG
(CHEMBL3110239)
Show SMILES CC(=S)N1CCc2[nH]c3ccc(Cl)cc3c2C1
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n/an/an/a>1.00E+5n/an/an/an/an/a



University of Cambridge

Curated by ChEMBL


Assay Description
Binding affinity to human BAZ2B expressed in Escherichia coli BL21(DE3) by direct isothermal titration calorimetric analysis


J Med Chem 56: 10183-7 (2013)

More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2B


(Homo sapiens (Human))
BDBM50098311
PNG
(CHEMBL3590408)
Show SMILES CN1CC[C@@H](Nc2ncc(-c3cncc(C)c3)c3cc(C)c(=O)[nH]c23)[C@@H](C1)OCC1CCS(=O)(=O)CC1
Show InChI InChI=1/C27H35N5O4S/c1-17-10-20(13-28-12-17)22-14-29-26(25-21(22)11-18(2)27(33)31-25)30-23-4-7-32(3)15-24(23)36-16-19-5-8-37(34,35)9-6-19/h10-14,19,23-24H,4-9,15-16H2,1-3H3,(H,29,30)(H,31,33)/t23-,24-/s2
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n/an/an/a<1.00E+5n/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Binding affinity to BAZ2B in human HUT78 cells incubated for 45 mins by mass spectrometry based bromosphere chemoproteomic assay


J Med Chem 58: 6151-78 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00773
BindingDB Entry DOI: 10.7270/Q2FN17Z1
More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2B


(Homo sapiens (Human))
BDBM50098250
PNG
(CHEMBL3590389)
Show SMILES Cc1cncc(c1)-c1cnc(N[C@@H]2CCNC[C@H]2OCC2CCCCC2)c2[nH]c(=O)c(C)cc12
Show InChI InChI=1/C27H35N5O2/c1-17-10-20(13-29-12-17)22-14-30-26(25-21(22)11-18(2)27(33)32-25)31-23-8-9-28-15-24(23)34-16-19-6-4-3-5-7-19/h10-14,19,23-24,28H,3-9,15-16H2,1-2H3,(H,30,31)(H,32,33)/t23-,24-/s2
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n/an/an/a<1.00E+5n/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Binding affinity to BAZ2B in human HUT78 cells incubated for 45 mins by mass spectrometry based bromosphere chemoproteomic assay


J Med Chem 58: 6151-78 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00773
BindingDB Entry DOI: 10.7270/Q2FN17Z1
More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2B


(Homo sapiens (Human))
BDBM50172114
PNG
(CHEMBL3808440)
Show SMILES COc1ccc(C)c(c1)N(C(=O)c1cccc(c1)C(F)(F)F)c1cn(C(C)=O)c2ccccc12
Show InChI InChI=1S/C26H21F3N2O3/c1-16-11-12-20(34-3)14-23(16)31(25(33)18-7-6-8-19(13-18)26(27,28)29)24-15-30(17(2)32)22-10-5-4-9-21(22)24/h4-15H,1-3H3
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n/an/an/a 1.40E+5n/an/an/an/an/a



University of Z£rich

Curated by ChEMBL


Assay Description
Competitive binding affinity to human His-tagged BRAZ2B (1858 to 1972 residues) expressed in T7 phage-infected Escherichia coli BL21(DE3) cells measu...


J Med Chem 59: 3087-97 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01757
BindingDB Entry DOI: 10.7270/Q2MP556R
More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2B


(Homo sapiens (Human))
BDBM50495383
PNG
(CHEMBL3110255)
Show SMILES CNc1ccc2[nH]c3CCN(Cc3c2c1)C(C)=O
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n/an/an/a 2.74E+5n/an/an/an/an/a



University of Cambridge

Curated by ChEMBL


Assay Description
Binding affinity to human BAZ2B expressed in Escherichia coli BL21(DE3) by competitive isothermal titration calorimetric analysis


J Med Chem 56: 10183-7 (2013)

More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2B


(Homo sapiens (Human))
BDBM50495370
PNG
(CHEMBL3110254)
Show SMILES CC(=O)N1CCc2[nH]c3ccc(N)cc3c2C1
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n/an/an/a 3.36E+5n/an/an/an/an/a



University of Cambridge

Curated by ChEMBL


Assay Description
Binding affinity to human BAZ2B expressed in Escherichia coli BL21(DE3) by competitive isothermal titration calorimetric analysis


J Med Chem 56: 10183-7 (2013)

More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2B


(Homo sapiens (Human))
BDBM50277367
PNG
(CHEMBL4163507)
Show SMILES CNC(=O)c1cc(Cl)ccn1
Show InChI InChI=1S/C7H7ClN2O/c1-9-7(11)6-4-5(8)2-3-10-6/h2-4H,1H3,(H,9,11)
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n/an/an/a>5.00E+5n/an/an/an/an/a



University of Z£rich

Curated by ChEMBL


Assay Description
Binding affinity to human BAZ2B (S2054 to S2168 residues) expressed in bacterial expression system by BROMOscan assay


Eur J Med Chem 139: 564-572 (2017)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Bromodomain adjacent to zinc finger domain protein 2B


(Homo sapiens (Human))
BDBM50277359
PNG
(CHEMBL1612460)
Show SMILES CC(=O)c1cccc(Oc2ncccn2)c1
Show InChI InChI=1S/C12H10N2O2/c1-9(15)10-4-2-5-11(8-10)16-12-13-6-3-7-14-12/h2-8H,1H3
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n/an/an/a>5.00E+5n/an/an/an/an/a



University of Z£rich

Curated by ChEMBL


Assay Description
Binding affinity to human BAZ2B (S2054 to S2168 residues) expressed in bacterial expression system by BROMOscan assay


Eur J Med Chem 139: 564-572 (2017)

More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2B


(Homo sapiens (Human))
BDBM50495380
PNG
(CHEMBL2441350)
Show SMILES NC(=S)c1cnccn1
Show InChI InChI=1S/C5H5N3S/c6-5(9)4-3-7-1-2-8-4/h1-3H,(H2,6,9)
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n/an/an/a 5.24E+5n/an/an/an/an/a



University of Cambridge

Curated by ChEMBL


Assay Description
Binding affinity to human BAZ2B expressed in Escherichia coli BL21(DE3) by direct isothermal titration calorimetric analysis


J Med Chem 56: 10183-7 (2013)

More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2B


(Homo sapiens (Human))
BDBM50495369
PNG
(CHEMBL3110260)
Show SMILES CC(=O)N1CCc2[nH]c3ccc(cc3c2C1)[N+]([O-])=O
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n/an/an/a 6.94E+5n/an/an/an/an/a



University of Cambridge

Curated by ChEMBL


Assay Description
Binding affinity to human BAZ2B expressed in Escherichia coli BL21(DE3) by competitive isothermal titration calorimetric analysis


J Med Chem 56: 10183-7 (2013)

More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2B


(Homo sapiens (Human))
BDBM50443231
PNG
(CHEMBL3086884)
Show SMILES Cc1cc(N=Nc2ccc(cc2)S(=O)(=O)Nc2ccccn2)c(N)c(C)c1O
Show InChI InChI=1S/C19H19N5O3S/c1-12-11-16(18(20)13(2)19(12)25)23-22-14-6-8-15(9-7-14)28(26,27)24-17-5-3-4-10-21-17/h3-11,25H,20H2,1-2H3,(H,21,24)/b23-22+
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2.26E+3n/an/an/an/an/an/an/an/a



Icahn School of Medicine at Mount Sinai

Curated by ChEMBL


Assay Description
Displacement of fluorescein-labeled MS239 from recombinant human BAZ2b after 1 hr by fluorescence anisotropy assay


J Med Chem 56: 9251-64 (2013)


Article DOI: 10.1021/jm401334s
BindingDB Entry DOI: 10.7270/Q2ZW1NCF
More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2B


(Homo sapiens (Human))
BDBM50443232
PNG
(CHEMBL3086883)
Show SMILES Cc1cc(N=Nc2ccc(cc2)S(=O)(=O)Nc2ccccn2)c(N)cc1O
Show InChI InChI=1S/C18H17N5O3S/c1-12-10-16(15(19)11-17(12)24)22-21-13-5-7-14(8-6-13)27(25,26)23-18-4-2-3-9-20-18/h2-11,24H,19H2,1H3,(H,20,23)/b22-21+
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3.29E+3n/an/an/an/an/an/an/an/a



Icahn School of Medicine at Mount Sinai

Curated by ChEMBL


Assay Description
Displacement of fluorescein-labeled MS239 from recombinant human BAZ2b after 1 hr by fluorescence anisotropy assay


J Med Chem 56: 9251-64 (2013)


Article DOI: 10.1021/jm401334s
BindingDB Entry DOI: 10.7270/Q2ZW1NCF
More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2B


(Homo sapiens (Human))
BDBM50443230
PNG
(CHEMBL3086885)
Show SMILES Cc1cc(N=Nc2ccc(cc2)S(=O)(=O)Nc2ccccn2)c(N)c(Cl)c1O
Show InChI InChI=1S/C18H16ClN5O3S/c1-11-10-14(17(20)16(19)18(11)25)23-22-12-5-7-13(8-6-12)28(26,27)24-15-4-2-3-9-21-15/h2-10,25H,20H2,1H3,(H,21,24)/b23-22+
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3.30E+3n/an/an/an/an/an/an/an/a



Icahn School of Medicine at Mount Sinai

Curated by ChEMBL


Assay Description
Displacement of fluorescein-labeled MS239 from recombinant human BAZ2b after 1 hr by fluorescence anisotropy assay


J Med Chem 56: 9251-64 (2013)


Article DOI: 10.1021/jm401334s
BindingDB Entry DOI: 10.7270/Q2ZW1NCF
More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2B


(Homo sapiens (Human))
BDBM50200384
PNG
(CHEMBL3968533 | US9763922, Example 299)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1ccc(cc1F)-c1cnn(C)c1)nn2[C@@H]1CCOC1
Show InChI InChI=1/C22H25FN6O2/c1-14(30)28-7-5-21-18(12-28)22(26-29(21)17-6-8-31-13-17)25-20-4-3-15(9-19(20)23)16-10-24-27(2)11-16/h3-4,9-11,17H,5-8,12-13H2,1-2H3,(H,25,26)/t17-/s2
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n/an/a>2.00E+4n/an/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Displacement of biotinylated ligand from recombinant His-tagged BAZ2B (unknown origin) measured after 10 mins by TR-FRET assay


J Med Chem 59: 10549-10563 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01022
BindingDB Entry DOI: 10.7270/Q27083DF
More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2B


(Homo sapiens (Human))
BDBM50200385
PNG
(CHEMBL3959584)
Show SMILES CC(=O)N1CCc2[nH]nc(Nc3ccccc3)c2C1
Show InChI InChI=1S/C14H16N4O/c1-10(19)18-8-7-13-12(9-18)14(17-16-13)15-11-5-3-2-4-6-11/h2-6H,7-9H2,1H3,(H2,15,16,17)
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n/an/a>2.00E+4n/an/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Displacement of biotinylated ligand from recombinant His-tagged BAZ2B (unknown origin) measured after 10 mins by TR-FRET assay


J Med Chem 59: 10549-10563 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01022
BindingDB Entry DOI: 10.7270/Q27083DF
More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2B


(Homo sapiens (Human))
BDBM50028142
PNG
(CHEMBL2177300)
Show SMILES C[C@H]1C[C@@H](Nc2ccc(Cl)cc2)c2cc(ccc2N1C(C)=O)-c1ccc(cc1)C(O)=O
Show InChI InChI=1/C25H23ClN2O3/c1-15-13-23(27-21-10-8-20(26)9-11-21)22-14-19(7-12-24(22)28(15)16(2)29)17-3-5-18(6-4-17)25(30)31/h3-12,14-15,23,27H,13H2,1-2H3,(H,30,31)/t15-,23+/s2
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n/an/a<3.16E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of BAZ2B (unknown origin) by BROMOscan assay


J Med Chem 57: 8111-31 (2014)


Article DOI: 10.1021/jm5010539
BindingDB Entry DOI: 10.7270/Q23R0VGR
More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2B


(Homo sapiens (Human))
BDBM50078630
PNG
(CHEMBL3415178)
Show SMILES Cc1cn(CCn2cnc(c2-c2ccc(cc2)C#N)-c2cccnc2)nn1
Show InChI InChI=1S/C20H17N7/c1-15-13-27(25-24-15)10-9-26-14-23-19(18-3-2-8-22-12-18)20(26)17-6-4-16(11-21)5-7-17/h2-8,12-14H,9-10H2,1H3
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n/an/a>5.00E+4n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Displacement of H3K14Ac from BAZ2B (unknown origin) preincubated for 30 mins with non-biotinylated peptide followed by addition of biotinylated pepti...


J Med Chem 58: 2553-9 (2015)


Article DOI: 10.1021/jm501963e
BindingDB Entry DOI: 10.7270/Q2V69M9B
More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2B


(Homo sapiens (Human))
BDBM50078631
PNG
(CHEMBL3415177)
Show SMILES Cc1cn(CCn2cnc(c2-c2ccc(cc2)C#N)-c2ccncc2)nn1
Show InChI InChI=1S/C20H17N7/c1-15-13-27(25-24-15)11-10-26-14-23-19(17-6-8-22-9-7-17)20(26)18-4-2-16(12-21)3-5-18/h2-9,13-14H,10-11H2,1H3
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n/an/a 4.40E+3n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Displacement of H3K14Ac from BAZ2B (unknown origin) preincubated for 30 mins with non-biotinylated peptide followed by addition of biotinylated pepti...


J Med Chem 58: 2553-9 (2015)


Article DOI: 10.1021/jm501963e
BindingDB Entry DOI: 10.7270/Q2V69M9B
More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2B


(Homo sapiens (Human))
BDBM50078632
PNG
(CHEMBL3415176)
Show SMILES Cc1cn(CCn2cnc(c2-c2ccc(cc2)C#N)-c2ccccc2)nn1
Show InChI InChI=1S/C21H18N6/c1-16-14-27(25-24-16)12-11-26-15-23-20(18-5-3-2-4-6-18)21(26)19-9-7-17(13-22)8-10-19/h2-10,14-15H,11-12H2,1H3
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n/an/a 2.60E+4n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Displacement of H3K14Ac from BAZ2B (unknown origin) preincubated for 30 mins with non-biotinylated peptide followed by addition of biotinylated pepti...


J Med Chem 58: 2553-9 (2015)


Article DOI: 10.1021/jm501963e
BindingDB Entry DOI: 10.7270/Q2V69M9B
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Bromodomain adjacent to zinc finger domain protein 2B


(Homo sapiens (Human))
BDBM50078641
PNG
(CHEMBL3415179)
Show SMILES Cc1cn(CCn2cnc(-c3cncs3)c2-c2ccc(cc2)C#N)nn1
Show InChI InChI=1S/C18H15N7S/c1-13-10-25(23-22-13)7-6-24-11-21-17(16-9-20-12-26-16)18(24)15-4-2-14(8-19)3-5-15/h2-5,9-12H,6-7H2,1H3
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n/an/a 5.25E+3n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Displacement of H3K14Ac from BAZ2B (unknown origin) preincubated for 30 mins with non-biotinylated peptide followed by addition of biotinylated pepti...


J Med Chem 58: 2553-9 (2015)


Article DOI: 10.1021/jm501963e
BindingDB Entry DOI: 10.7270/Q2V69M9B
More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2B


(Homo sapiens (Human))
BDBM50078640
PNG
(CHEMBL3415180)
Show SMILES Cc1cn(CCn2cnc(-c3cc(C)no3)c2-c2ccc(cc2)C#N)nn1
Show InChI InChI=1S/C19H17N7O/c1-13-9-17(27-23-13)18-19(16-5-3-15(10-20)4-6-16)25(12-21-18)7-8-26-11-14(2)22-24-26/h3-6,9,11-12H,7-8H2,1-2H3
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The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Displacement of H3K14Ac from BAZ2B (unknown origin) preincubated for 30 mins with non-biotinylated peptide followed by addition of biotinylated pepti...


J Med Chem 58: 2553-9 (2015)


Article DOI: 10.1021/jm501963e
BindingDB Entry DOI: 10.7270/Q2V69M9B
More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2B


(Homo sapiens (Human))
BDBM50078639
PNG
(CHEMBL3415181)
Show SMILES Cc1cn(CCn2cncc2-c2ccc(cc2)C#N)nn1
Show InChI InChI=1S/C15H14N6/c1-12-10-21(19-18-12)7-6-20-11-17-9-15(20)14-4-2-13(8-16)3-5-14/h2-5,9-11H,6-7H2,1H3
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n/an/a>5.00E+4n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Displacement of H3K14Ac from BAZ2B (unknown origin) preincubated for 30 mins with non-biotinylated peptide followed by addition of biotinylated pepti...


J Med Chem 58: 2553-9 (2015)


Article DOI: 10.1021/jm501963e
BindingDB Entry DOI: 10.7270/Q2V69M9B
More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2B


(Homo sapiens (Human))
BDBM50078638
PNG
(CHEMBL3415182)
Show SMILES Cc1cn(CCn2cnc(-c3cnn(C)c3)c2-c2ccc(cc2)C#N)nn1
Show InChI InChI=1S/C19H18N8/c1-14-11-27(24-23-14)8-7-26-13-21-18(17-10-22-25(2)12-17)19(26)16-5-3-15(9-20)4-6-16/h3-6,10-13H,7-8H2,1-2H3
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n/an/a 1.07E+3n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Displacement of H3K14Ac from BAZ2B (unknown origin) preincubated for 30 mins with non-biotinylated peptide followed by addition of biotinylated pepti...


J Med Chem 58: 2553-9 (2015)


Article DOI: 10.1021/jm501963e
BindingDB Entry DOI: 10.7270/Q2V69M9B
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Bromodomain adjacent to zinc finger domain protein 2B


(Homo sapiens (Human))
BDBM50078637
PNG
(CHEMBL3415183)
Show SMILES Cn1cc(cn1)-c1ncn(C)c1-c1ccc(cc1)C#N
Show InChI InChI=1S/C15H13N5/c1-19-10-17-14(13-8-18-20(2)9-13)15(19)12-5-3-11(7-16)4-6-12/h3-6,8-10H,1-2H3
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n/an/a>5.00E+4n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Displacement of H3K14Ac from BAZ2B (unknown origin) preincubated for 30 mins with non-biotinylated peptide followed by addition of biotinylated pepti...


J Med Chem 58: 2553-9 (2015)


Article DOI: 10.1021/jm501963e
BindingDB Entry DOI: 10.7270/Q2V69M9B
More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2B


(Homo sapiens (Human))
BDBM50078636
PNG
(CHEMBL3415184)
Show SMILES Cc1cn(Cn2cnc(-c3cnn(C)c3)c2-c2ccc(cc2F)C#N)nn1
Show InChI InChI=1S/C18H15FN8/c1-12-8-27(24-23-12)11-26-10-21-17(14-7-22-25(2)9-14)18(26)15-4-3-13(6-20)5-16(15)19/h3-5,7-10H,11H2,1-2H3
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n/an/a 770n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Displacement of H3K14Ac from BAZ2B (unknown origin) preincubated for 30 mins with non-biotinylated peptide followed by addition of biotinylated pepti...


J Med Chem 58: 2553-9 (2015)


Article DOI: 10.1021/jm501963e
BindingDB Entry DOI: 10.7270/Q2V69M9B
More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2B


(Homo sapiens (Human))
BDBM50078635
PNG
(CHEMBL3415185)
Show SMILES Cc1cn(Cn2cnc(-c3cnn(C)c3)c2-c2ccc(C#N)c(F)c2)nn1
Show InChI InChI=1S/C18H15FN8/c1-12-8-27(24-23-12)11-26-10-21-17(15-7-22-25(2)9-15)18(26)13-3-4-14(6-20)16(19)5-13/h3-5,7-10H,11H2,1-2H3
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n/an/a 790n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Displacement of H3K14Ac from BAZ2B (unknown origin) preincubated for 30 mins with non-biotinylated peptide followed by addition of biotinylated pepti...


J Med Chem 58: 2553-9 (2015)


Article DOI: 10.1021/jm501963e
BindingDB Entry DOI: 10.7270/Q2V69M9B
More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2B


(Homo sapiens (Human))
BDBM50078634
PNG
(CHEMBL3415186)
Show SMILES Cc1cn(Cn2cnc(-c3cnn(C)c3)c2-c2ccc(cc2)[N+]([O-])=O)nn1
Show InChI InChI=1S/C17H16N8O2/c1-12-8-24(21-20-12)11-23-10-18-16(14-7-19-22(2)9-14)17(23)13-3-5-15(6-4-13)25(26)27/h3-10H,11H2,1-2H3
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n/an/a 2.45E+3n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Displacement of H3K14Ac from BAZ2B (unknown origin) preincubated for 30 mins with non-biotinylated peptide followed by addition of biotinylated pepti...


J Med Chem 58: 2553-9 (2015)


Article DOI: 10.1021/jm501963e
BindingDB Entry DOI: 10.7270/Q2V69M9B
More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2B


(Homo sapiens (Human))
BDBM50078633
PNG
(CHEMBL3415187)
Show SMILES Cn1cc(Cn2cnc(-c3cnn(C)c3)c2-c2ccc(cc2)C#N)cn1
Show InChI InChI=1S/C19H17N7/c1-24-10-15(8-22-24)11-26-13-21-18(17-9-23-25(2)12-17)19(26)16-5-3-14(7-20)4-6-16/h3-6,8-10,12-13H,11H2,1-2H3
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n/an/a 180n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Displacement of H3K14Ac from BAZ2B (unknown origin) preincubated for 30 mins with non-biotinylated peptide followed by addition of biotinylated pepti...


J Med Chem 58: 2553-9 (2015)


Article DOI: 10.1021/jm501963e
BindingDB Entry DOI: 10.7270/Q2V69M9B
More data for this
Ligand-Target Pair
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