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Found 237 hits Enz. Inhib. hit(s) with Target = 'Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM179477
PNG
(US9675697, Cpd. No. 44)
Show SMILES COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ccnc(-c3c(C)[nH]c4ccccc34)c21
Show InChI InChI=1S/C26H22N4O2/c1-13-24(16-7-5-6-8-19(16)28-13)26-25-17-12-22(31-4)18(23-14(2)30-32-15(23)3)11-21(17)29-20(25)9-10-27-26/h5-12,28-29H,1-4H3
GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/an/a 27n/an/an/a7.4n/a



The Regents of the University of Michigan

US Patent


Assay Description
Biotin labeled BRD proteins (10 μg/ml) in kinetic assay buffer (PBS, pH 7.4, 0.1% BSA and 0.01% Tween-20) were immobilized on Super Streptavidin...


US Patent US9675697 (2017)


Article DOI: 10.1021/jm970615f
BindingDB Entry DOI: 10.7270/Q2CC0XV6
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM50092310
PNG
(CHEMBL3581661 | US9675697, Cpd. No. 23)
Show SMILES COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ccnc(-c3c(C)[nH]nc3C3CC3)c21
Show InChI InChI=1S/C24H23N5O2/c1-11-21(23(28-27-11)14-5-6-14)24-22-15-10-19(30-4)16(20-12(2)29-31-13(20)3)9-18(15)26-17(22)7-8-25-24/h7-10,14,26H,5-6H2,1-4H3,(H,27,28)
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CHEMBL
PC cid
PC sid
PDB
UniChem

Similars

Article
US Patent
n/an/an/a 29n/an/an/a7.4n/a



The Regents of the University of Michigan

US Patent


Assay Description
Biotin labeled BRD proteins (10 μg/ml) in kinetic assay buffer (PBS, pH 7.4, 0.1% BSA and 0.01% Tween-20) were immobilized on Super Streptavidin...


US Patent US9675697 (2017)


Article DOI: 10.1021/jm970615f
BindingDB Entry DOI: 10.7270/Q2CC0XV6
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM50092341
PNG
(CHEMBL3581660 | US9675697, Cpd. No. 22)
Show SMILES CCc1n[nH]c(CC)c1-c1nccc2[nH]c3cc(-c4c(C)noc4C)c(OC)cc3c12
Show InChI InChI=1S/C24H25N5O2/c1-6-16-23(17(7-2)28-27-16)24-22-14-11-20(30-5)15(21-12(3)29-31-13(21)4)10-19(14)26-18(22)8-9-25-24/h8-11,26H,6-7H2,1-5H3,(H,27,28)
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CHEMBL
PC cid
PC sid
UniChem

Similars

Article
US Patent
n/an/an/a 40n/an/an/a7.4n/a



The Regents of the University of Michigan

US Patent


Assay Description
Biotin labeled BRD proteins (10 μg/ml) in kinetic assay buffer (PBS, pH 7.4, 0.1% BSA and 0.01% Tween-20) were immobilized on Super Streptavidin...


US Patent US9675697 (2017)


Article DOI: 10.1021/jm970615f
BindingDB Entry DOI: 10.7270/Q2CC0XV6
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM179474
PNG
(US9675697, Cpd. No. 25)
Show SMILES COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ccnc(-c3c(C)nnc3-c3ccccc3)c21
Show InChI InChI=1S/C27H21N5O2/c1-14-24(26(31-30-14)17-8-6-5-7-9-17)27-25-18-13-22(33-4)19(23-15(2)32-34-16(23)3)12-21(18)29-20(25)10-11-28-27/h5-13H,1-4H3/b27-24-
GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/an/a 60n/an/an/a7.4n/a



The Regents of the University of Michigan

US Patent


Assay Description
Biotin labeled BRD proteins (10 μg/ml) in kinetic assay buffer (PBS, pH 7.4, 0.1% BSA and 0.01% Tween-20) were immobilized on Super Streptavidin...


US Patent US9675697 (2017)


Article DOI: 10.1021/jm970615f
BindingDB Entry DOI: 10.7270/Q2CC0XV6
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM404301
PNG
(US10017501, Compound 1020-289)
Show SMILES Cc1noc(C)c1-c1cc(c2nc([nH]c2c1)C1CC1)C(O)(C1CCCO1)c1ccccc1
Show InChI InChI=1/C26H27N3O3/c1-15-23(16(2)32-29-15)18-13-20(24-21(14-18)27-25(28-24)17-10-11-17)26(30,22-9-6-12-31-22)19-7-4-3-5-8-19/h3-5,7-8,13-14,17,22,30H,6,9-12H2,1-2H3,(H,27,28)
GoogleScholar
PC cid
PC sid
UniChem
US Patent
2n/an/an/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...


US Patent US10017501 (2018)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM249309
PNG
(US10017501, Compound 1020-114 | US9458145, 1020-11...)
Show SMILES Cc1noc(C)c1-c1cc(c2nc([nH]c2c1)C1CC1)C(O)(C1CCCO1)c1cccc(C)n1
Show InChI InChI=1/C26H28N4O3/c1-14-6-4-7-21(27-14)26(31,22-8-5-11-32-22)19-12-18(23-15(2)30-33-16(23)3)13-20-24(19)29-25(28-20)17-9-10-17/h4,6-7,12-13,17,22,31H,5,8-11H2,1-3H3,(H,28,29)
GoogleScholar
PC cid
PC sid
UniChem
US Patent
3.80n/an/an/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...


US Patent US10017501 (2018)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM249305
PNG
(US10017501, Compound 1020-103 | US9458145, 1020-10...)
Show SMILES Cc1noc(C)c1-c1cc(c2nc([nH]c2c1)C1CC1)C(O)(c1nccs1)c1nccs1
Show InChI InChI=1S/C22H19N5O2S2/c1-11-17(12(2)29-27-11)14-9-15(18-16(10-14)25-19(26-18)13-3-4-13)22(28,20-23-5-7-30-20)21-24-6-8-31-21/h5-10,13,28H,3-4H2,1-2H3,(H,25,26)
GoogleScholar
PC cid
PC sid
UniChem
US Patent
4n/an/an/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...


US Patent US10017501 (2018)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM249312
PNG
(US10017501, Compound 1020-257 | US9458145, 1020-25...)
Show SMILES Cc1noc(C)c1-c1cc(c2nc([nH]c2c1)C1CC1)C(O)(c1ncccn1)c1ccc(F)cc1F
Show InChI InChI=1/C26H21F2N5O2/c1-13-22(14(2)35-33-13)16-10-19(23-21(11-16)31-24(32-23)15-4-5-15)26(34,25-29-8-3-9-30-25)18-7-6-17(27)12-20(18)28/h3,6-12,15,34H,4-5H2,1-2H3,(H,31,32)
GoogleScholar
PC cid
PC sid
UniChem
US Patent
4.70n/an/an/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...


US Patent US10017501 (2018)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM249314
PNG
(US10017501, Compound 1020-298 | US9458145, 1020-29...)
Show SMILES Cc1noc(C)c1-c1cc(c2nc([nH]c2c1)C1CC1)C(O)(C1CCC(C)(C)O1)c1cccnn1
Show InChI InChI=1/C26H29N5O3/c1-14-22(15(2)34-31-14)17-12-18(23-19(13-17)28-24(29-23)16-7-8-16)26(32,20-6-5-11-27-30-20)21-9-10-25(3,4)33-21/h5-6,11-13,16,21,32H,7-10H2,1-4H3,(H,28,29)
GoogleScholar
PC cid
PC sid
UniChem
US Patent
5.40n/an/an/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...


US Patent US10017501 (2018)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM249311
PNG
(US10017501, Compound 1020-239 | US9458145, 1020-23...)
Show SMILES Cc1noc(C)c1-c1cc(c2nc([nH]c2c1)C1CC1)C(O)(c1ccccn1)c1ncccn1
Show InChI InChI=1/C25H22N6O2/c1-14-21(15(2)33-31-14)17-12-18(22-19(13-17)29-23(30-22)16-7-8-16)25(32,20-6-3-4-9-26-20)24-27-10-5-11-28-24/h3-6,9-13,16,32H,7-8H2,1-2H3,(H,29,30)
GoogleScholar
PC cid
PC sid
UniChem
US Patent
5.90n/an/an/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...


US Patent US10017501 (2018)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM249306
PNG
(US10017501, Compound 1020-104 | US9458145, 1020-10...)
Show SMILES Cc1noc(C)c1-c1cc(c2nc([nH]c2c1)C1CC1)C(O)(c1ccccn1)c1ccccn1
Show InChI InChI=1S/C26H23N5O2/c1-15-23(16(2)33-31-15)18-13-19(24-20(14-18)29-25(30-24)17-9-10-17)26(32,21-7-3-5-11-27-21)22-8-4-6-12-28-22/h3-8,11-14,17,32H,9-10H2,1-2H3,(H,29,30)
GoogleScholar
PC cid
PC sid
UniChem
US Patent
7.20n/an/an/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...


US Patent US10017501 (2018)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM179480
PNG
(US9675697, Cpd. No. 68)
Show SMILES COc1cc2c(cc1-c1c(C)noc1C)[nH]c1nc(C)nc(-c3c(C)[nH]c4ccccc34)c21
Show InChI InChI=1S/C26H23N5O2/c1-12-23(16-8-6-7-9-19(16)27-12)25-24-17-11-21(32-5)18(22-13(2)31-33-14(22)3)10-20(17)30-26(24)29-15(4)28-25/h6-11,27H,1-5H3,(H,28,29,30)
GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
7.30 -46.4n/an/an/an/an/an/a25



The Regents of the University of Michigan

US Patent


Assay Description
Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...


US Patent US9675697 (2017)


Article DOI: 10.1021/jm970615f
BindingDB Entry DOI: 10.7270/Q2CC0XV6
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM179485
PNG
(US9675697, Cpd. No. 183)
Show SMILES COc1cc2c(cc1-c1c(C)noc1C)[nH]c1nc(C)nc(-c3cccc(c3)C(C)(C)O)c21
Show InChI InChI=1S/C26H26N4O3/c1-13-22(14(2)33-30-13)19-11-20-18(12-21(19)32-6)23-24(27-15(3)28-25(23)29-20)16-8-7-9-17(10-16)26(4,5)31/h7-12,31H,1-6H3,(H,27,28,29)
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PC cid
PC sid
UniChem
Article
US Patent
7.90 -46.2n/an/an/an/an/an/a25



The Regents of the University of Michigan

US Patent


Assay Description
Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...


US Patent US9675697 (2017)


Article DOI: 10.1021/jm970615f
BindingDB Entry DOI: 10.7270/Q2CC0XV6
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM179638
PNG
(US9675697, Cpd. No. 319)
Show SMILES COc1cc2c(cc1-c1c(C)noc1C)[nH]c1nc(C)nc(-c3cc(cc(c3)C(C)(C)C)C(=O)NC3CCN(C)CC3)c21
Show InChI InChI=1S/C34H40N6O3/c1-18-29(19(2)43-39-18)26-16-27-25(17-28(26)42-8)30-31(35-20(3)36-32(30)38-27)21-13-22(15-23(14-21)34(4,5)6)33(41)37-24-9-11-40(7)12-10-24/h13-17,24H,9-12H2,1-8H3,(H,37,41)(H,35,36,38)
GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
9 -45.9n/an/an/an/an/an/a25



The Regents of the University of Michigan

US Patent


Assay Description
Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...


US Patent US9675697 (2017)


Article DOI: 10.1021/jm970615f
BindingDB Entry DOI: 10.7270/Q2CC0XV6
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM179639
PNG
(US9675697, Cpd. No. 322)
Show SMILES COc1cc2c(cc1-c1c(C)noc1C)[nH]c1nc(C)nc(-c3cc(cc(c3)C(C)(C)C)C(=O)NC3CCN(CC3)C3COC3)c21
Show InChI InChI=1S/C36H42N6O4/c1-19-31(20(2)46-41-19)28-15-29-27(16-30(28)44-7)32-33(37-21(3)38-34(32)40-29)22-12-23(14-24(13-22)36(4,5)6)35(43)39-25-8-10-42(11-9-25)26-17-45-18-26/h12-16,25-26H,8-11,17-18H2,1-7H3,(H,39,43)(H,37,38,40)
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PC cid
PC sid
UniChem
Article
US Patent
10 -45.7n/an/an/an/an/an/a25



The Regents of the University of Michigan

US Patent


Assay Description
Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...


US Patent US9675697 (2017)


Article DOI: 10.1021/jm970615f
BindingDB Entry DOI: 10.7270/Q2CC0XV6
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM249307
PNG
(US10017501, Compound 1020-112 | US9458145, 1020-11...)
Show SMILES Cc1noc(C)c1-c1cc(c2nc([nH]c2c1)C1CC1)C(O)(c1ccccc1)c1cccnc1
Show InChI InChI=1/C27H24N4O2/c1-16-24(17(2)33-31-16)19-13-22(25-23(14-19)29-26(30-25)18-10-11-18)27(32,20-7-4-3-5-8-20)21-9-6-12-28-15-21/h3-9,12-15,18,32H,10-11H2,1-2H3,(H,29,30)
GoogleScholar
PC cid
PC sid
UniChem
US Patent
10.4n/an/an/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...


US Patent US10017501 (2018)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM249308
PNG
(US10017501, Compound 1020-113 | US9458145, 1020-11...)
Show SMILES Cc1noc(C)c1-c1cc(c2nc([nH]c2c1)C1CC1)C(O)(c1ccccc1)c1ccccn1
Show InChI InChI=1/C27H24N4O2/c1-16-24(17(2)33-31-16)19-14-21(25-22(15-19)29-26(30-25)18-11-12-18)27(32,20-8-4-3-5-9-20)23-10-6-7-13-28-23/h3-10,13-15,18,32H,11-12H2,1-2H3,(H,29,30)
GoogleScholar
PC cid
PC sid
UniChem
US Patent
10.7n/an/an/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...


US Patent US10017501 (2018)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM249310
PNG
(US10017501, Compound 1020-224 | US9458145, 1020-22...)
Show SMILES Cc1noc(C)c1-c1cc(c2nc([nH]c2c1F)C1CC1)C(O)(c1ccccn1)c1ccccn1
Show InChI InChI=1S/C26H22FN5O2/c1-14-21(15(2)34-32-14)17-13-18(23-24(22(17)27)31-25(30-23)16-9-10-16)26(33,19-7-3-5-11-28-19)20-8-4-6-12-29-20/h3-8,11-13,16,33H,9-10H2,1-2H3,(H,30,31)
GoogleScholar
PC cid
PC sid
UniChem
US Patent
10.8n/an/an/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...


US Patent US10017501 (2018)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM179633
PNG
(US9675697, Cpd. No. 316)
Show SMILES COc1cc2c(cc1-c1c(C)noc1C)[nH]c1nc(C)nc(-c3ccc(NC(=O)N4CCN(C)CC4)c4ccccc34)c21
Show InChI InChI=1S/C33H33N7O3/c1-18-29(19(2)43-38-18)25-16-27-24(17-28(25)42-5)30-31(34-20(3)35-32(30)36-27)23-10-11-26(22-9-7-6-8-21(22)23)37-33(41)40-14-12-39(4)13-15-40/h6-11,16-17H,12-15H2,1-5H3,(H,37,41)(H,34,35,36)
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PC cid
PC sid
UniChem
Article
US Patent
11 -45.4n/an/an/an/an/an/a25



The Regents of the University of Michigan

US Patent


Assay Description
Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...


US Patent US9675697 (2017)


Article DOI: 10.1021/jm970615f
BindingDB Entry DOI: 10.7270/Q2CC0XV6
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM179490
PNG
(US9675697, Cpd. No. 196)
Show SMILES COc1cc2c(cc1-c1c(C)noc1C)[nH]c1nc(C)nc(-c3ccc(C(=O)NC4CCN(C)CC4)c4ccccc34)c21
Show InChI InChI=1S/C34H34N6O3/c1-18-30(19(2)43-39-18)27-16-28-26(17-29(27)42-5)31-32(35-20(3)36-33(31)38-28)24-10-11-25(23-9-7-6-8-22(23)24)34(41)37-21-12-14-40(4)15-13-21/h6-11,16-17,21H,12-15H2,1-5H3,(H,37,41)(H,35,36,38)
GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
12 -45.2n/an/an/an/an/an/a25



The Regents of the University of Michigan

US Patent


Assay Description
Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...


US Patent US9675697 (2017)


Article DOI: 10.1021/jm970615f
BindingDB Entry DOI: 10.7270/Q2CC0XV6
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM179492
PNG
(US9675697, Cpd. No. 207)
Show SMILES COc1cc2c(cc1-c1c(C)noc1C)[nH]c1nc(C)nc(-c3ccc(C(=O)N4CCN(C)CC4)c4ccccc34)c21
Show InChI InChI=1S/C33H32N6O3/c1-18-29(19(2)42-37-18)26-16-27-25(17-28(26)41-5)30-31(34-20(3)35-32(30)36-27)23-10-11-24(22-9-7-6-8-21(22)23)33(40)39-14-12-38(4)13-15-39/h6-11,16-17H,12-15H2,1-5H3,(H,34,35,36)
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15 -44.7n/an/an/an/an/an/a25



The Regents of the University of Michigan

US Patent


Assay Description
Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...


US Patent US9675697 (2017)


Article DOI: 10.1021/jm970615f
BindingDB Entry DOI: 10.7270/Q2CC0XV6
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM179491
PNG
(US9675697, Cpd. No. 197)
Show SMILES COc1cc2c(cc1-c1c(C)noc1C)[nH]c1nc(C)nc(-c3ccc(C(=O)NC4CCN(CC4)C4COC4)c4ccccc34)c21
Show InChI InChI=1S/C36H36N6O4/c1-19-32(20(2)46-41-19)29-15-30-28(16-31(29)44-4)33-34(37-21(3)38-35(33)40-30)26-9-10-27(25-8-6-5-7-24(25)26)36(43)39-22-11-13-42(14-12-22)23-17-45-18-23/h5-10,15-16,22-23H,11-14,17-18H2,1-4H3,(H,39,43)(H,37,38,40)
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17 -44.3n/an/an/an/an/an/a25



The Regents of the University of Michigan

US Patent


Assay Description
Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...


US Patent US9675697 (2017)


Article DOI: 10.1021/jm970615f
BindingDB Entry DOI: 10.7270/Q2CC0XV6
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM179574
PNG
(US9675697, Cpd. No. 212)
Show SMILES COc1cc2c(cc1-c1c(C)noc1C)[nH]c1nc(C)nc(-c3cc([nH]c3C(C)C)C(=O)NC3CCN(CC3)C3CCOCC3)c21
Show InChI InChI=1S/C35H43N7O4/c1-18(2)32-26(16-28(39-32)35(43)38-22-7-11-42(12-8-22)23-9-13-45-14-10-23)33-31-24-17-29(44-6)25(30-19(3)41-46-20(30)4)15-27(24)40-34(31)37-21(5)36-33/h15-18,22-23,39H,7-14H2,1-6H3,(H,38,43)(H,36,37,40)
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17 -44.3n/an/an/an/an/an/a25



The Regents of the University of Michigan

US Patent


Assay Description
Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...


US Patent US9675697 (2017)


Article DOI: 10.1021/jm970615f
BindingDB Entry DOI: 10.7270/Q2CC0XV6
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM179493
PNG
(US9675697, Cpd. No. 211)
Show SMILES COc1cc2c(cc1-c1c(C)noc1C)[nH]c1nc(C)nc(-c3cc([nH]c3C(C)C)C(=O)NC3CCN(C)CC3)c21
Show InChI InChI=1S/C31H37N7O3/c1-15(2)28-22(13-24(35-28)31(39)34-19-8-10-38(6)11-9-19)29-27-20-14-25(40-7)21(26-16(3)37-41-17(26)4)12-23(20)36-30(27)33-18(5)32-29/h12-15,19,35H,8-11H2,1-7H3,(H,34,39)(H,32,33,36)
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17 -44.3n/an/an/an/an/an/a25



The Regents of the University of Michigan

US Patent


Assay Description
Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...


US Patent US9675697 (2017)


Article DOI: 10.1021/jm970615f
BindingDB Entry DOI: 10.7270/Q2CC0XV6
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM179627
PNG
(US9675697, Cpd. No. 213)
Show SMILES COc1cc2c(cc1-c1c(C)noc1C)[nH]c1nc(C)nc(-c3cc([nH]c3C(C)C)C(=O)NC3CCN(CC3)C3COC3)c21
Show InChI InChI=1S/C33H39N7O4/c1-16(2)30-24(12-26(37-30)33(41)36-20-7-9-40(10-8-20)21-14-43-15-21)31-29-22-13-27(42-6)23(28-17(3)39-44-18(28)4)11-25(22)38-32(29)35-19(5)34-31/h11-13,16,20-21,37H,7-10,14-15H2,1-6H3,(H,36,41)(H,34,35,38)
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21 -43.8n/an/an/an/an/an/a25



The Regents of the University of Michigan

US Patent


Assay Description
Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...


US Patent US9675697 (2017)


Article DOI: 10.1021/jm970615f
BindingDB Entry DOI: 10.7270/Q2CC0XV6
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM50092310
PNG
(CHEMBL3581661 | US9675697, Cpd. No. 23)
Show SMILES COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ccnc(-c3c(C)[nH]nc3C3CC3)c21
Show InChI InChI=1S/C24H23N5O2/c1-11-21(23(28-27-11)14-5-6-14)24-22-15-10-19(30-4)16(20-12(2)29-31-13(20)3)9-18(15)26-17(22)7-8-25-24/h7-10,14,26H,5-6H2,1-4H3,(H,27,28)
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25 -43.4n/an/an/an/an/an/a25



The Regents of the University of Michigan

US Patent


Assay Description
Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...


US Patent US9675697 (2017)


Article DOI: 10.1021/jm970615f
BindingDB Entry DOI: 10.7270/Q2CC0XV6
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM179474
PNG
(US9675697, Cpd. No. 25)
Show SMILES COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ccnc(-c3c(C)nnc3-c3ccccc3)c21
Show InChI InChI=1S/C27H21N5O2/c1-14-24(26(31-30-14)17-8-6-5-7-9-17)27-25-18-13-22(33-4)19(23-15(2)32-34-16(23)3)12-21(18)29-20(25)10-11-28-27/h5-13H,1-4H3/b27-24-
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27 -43.2n/an/an/an/an/an/a25



The Regents of the University of Michigan

US Patent


Assay Description
Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...


US Patent US9675697 (2017)


Article DOI: 10.1021/jm970615f
BindingDB Entry DOI: 10.7270/Q2CC0XV6
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM179481
PNG
(US9675697, Cpd. No. 73)
Show SMILES COc1cc2c(cc1-c1c(C)noc1C)[nH]c1nc(C)nc(-c3ccnc4ccccc34)c21
Show InChI InChI=1S/C26H21N5O2/c1-13-23(14(2)33-31-13)19-11-21-18(12-22(19)32-4)24-25(28-15(3)29-26(24)30-21)17-9-10-27-20-8-6-5-7-16(17)20/h5-12H,1-4H3,(H,28,29,30)
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35 -42.6n/an/an/an/an/an/a25



The Regents of the University of Michigan

US Patent


Assay Description
Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...


US Patent US9675697 (2017)


Article DOI: 10.1021/jm970615f
BindingDB Entry DOI: 10.7270/Q2CC0XV6
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM179637
PNG
(US9675697, Cpd. No. 317)
Show SMILES COc1cc2c(cc1-c1c(C)noc1C)[nH]c1nc(C)nc(-c3ccc(NC(=O)N4CCN(CC4)C4COC4)c4ccccc34)c21
Show InChI InChI=1S/C35H35N7O4/c1-19-31(20(2)46-40-19)27-15-29-26(16-30(27)44-4)32-33(36-21(3)37-34(32)38-29)25-9-10-28(24-8-6-5-7-23(24)25)39-35(43)42-13-11-41(12-14-42)22-17-45-18-22/h5-10,15-16,22H,11-14,17-18H2,1-4H3,(H,39,43)(H,36,37,38)
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39 -42.3n/an/an/an/an/an/a25



The Regents of the University of Michigan

US Patent


Assay Description
Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...


US Patent US9675697 (2017)


Article DOI: 10.1021/jm970615f
BindingDB Entry DOI: 10.7270/Q2CC0XV6
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM50092341
PNG
(CHEMBL3581660 | US9675697, Cpd. No. 22)
Show SMILES CCc1n[nH]c(CC)c1-c1nccc2[nH]c3cc(-c4c(C)noc4C)c(OC)cc3c12
Show InChI InChI=1S/C24H25N5O2/c1-6-16-23(17(7-2)28-27-16)24-22-14-11-20(30-5)15(21-12(3)29-31-13(21)4)10-19(14)26-18(22)8-9-25-24/h8-11,26H,6-7H2,1-5H3,(H,27,28)
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44 -42.0n/an/an/an/an/an/a25



The Regents of the University of Michigan

US Patent


Assay Description
Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...


US Patent US9675697 (2017)


Article DOI: 10.1021/jm970615f
BindingDB Entry DOI: 10.7270/Q2CC0XV6
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM50092324
PNG
(CHEMBL3581655 | US9675697, Cpd. No. 1)
Show SMILES COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ccnc(-c3c(C)noc3C)c21
Show InChI InChI=1S/C22H20N4O3/c1-10-19(12(3)28-25-10)15-8-17-14(9-18(15)27-5)21-16(24-17)6-7-23-22(21)20-11(2)26-29-13(20)4/h6-9,24H,1-5H3
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48 -41.8n/an/an/an/an/an/a25



The Regents of the University of Michigan

US Patent


Assay Description
Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...


US Patent US9675697 (2017)


Article DOI: 10.1021/jm970615f
BindingDB Entry DOI: 10.7270/Q2CC0XV6
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM50092323
PNG
(CHEMBL3581656 | US9675697, Cpd. No. 21)
Show SMILES COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ccnc(-c3c(C)n[nH]c3C)c21
Show InChI InChI=1S/C22H21N5O2/c1-10-19(11(2)26-25-10)22-21-14-9-18(28-5)15(20-12(3)27-29-13(20)4)8-17(14)24-16(21)6-7-23-22/h6-9,24H,1-5H3,(H,25,26)
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99 -40.0n/an/an/an/an/an/a25



The Regents of the University of Michigan

US Patent


Assay Description
Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...


US Patent US9675697 (2017)


Article DOI: 10.1021/jm970615f
BindingDB Entry DOI: 10.7270/Q2CC0XV6
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM179640
PNG
(US9675697, Cpd. No. 352)
Show SMILES COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ccnc(-c3cn(nc3C)-c3ccccc3)c21
Show InChI InChI=1S/C27H23N5O2/c1-15-21(14-32(30-15)18-8-6-5-7-9-18)27-26-19-13-24(33-4)20(25-16(2)31-34-17(25)3)12-23(19)29-22(26)10-11-28-27/h5-14,29H,1-4H3
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103 -39.9n/an/an/an/an/an/a25



The Regents of the University of Michigan

US Patent


Assay Description
Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...


US Patent US9675697 (2017)


Article DOI: 10.1021/jm970615f
BindingDB Entry DOI: 10.7270/Q2CC0XV6
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM50092316
PNG
(CHEMBL3581658 | US9675697, Cpd. No. 24)
Show SMILES COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ccnc(-c3c(C)nn(C)c3C)c21
Show InChI InChI=1S/C23H23N5O2/c1-11-20(13(3)28(5)26-11)23-22-15-10-19(29-6)16(21-12(2)27-30-14(21)4)9-18(15)25-17(22)7-8-24-23/h7-10,25H,1-6H3
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116 -39.6n/an/an/an/an/an/a25



The Regents of the University of Michigan

US Patent


Assay Description
Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...


US Patent US9675697 (2017)


Article DOI: 10.1021/jm970615f
BindingDB Entry DOI: 10.7270/Q2CC0XV6
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM50092318
PNG
(CHEMBL3581657 | US9675697, Cpd. No. 2)
Show SMILES COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ccnc(-c3cn[nH]c3)c21
Show InChI InChI=1S/C20H17N5O2/c1-10-18(11(2)27-25-10)14-6-16-13(7-17(14)26-3)19-15(24-16)4-5-21-20(19)12-8-22-23-9-12/h4-9,24H,1-3H3,(H,22,23)
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247 -37.7n/an/an/an/an/an/a25



The Regents of the University of Michigan

US Patent


Assay Description
Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...


US Patent US9675697 (2017)


Article DOI: 10.1021/jm970615f
BindingDB Entry DOI: 10.7270/Q2CC0XV6
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM50092330
PNG
(CHEMBL3581649 | US9675697, RX-3)
Show SMILES COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ccnc(Cl)c21
Show InChI InChI=1S/C17H14ClN3O2/c1-8-15(9(2)23-21-8)11-6-13-10(7-14(11)22-3)16-12(20-13)4-5-19-17(16)18/h4-7,20H,1-3H3
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305 -37.2n/an/an/an/an/an/a25



The Regents of the University of Michigan

US Patent


Assay Description
Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...


US Patent US9675697 (2017)


Article DOI: 10.1021/jm970615f
BindingDB Entry DOI: 10.7270/Q2CC0XV6
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM186322
PNG
(US9675697, RX-39)
Show SMILES CCc1noc(C)c1-c1cc2[nH]c3ccnc(Cl)c3c2cc1OC
Show InChI InChI=1S/C18H16ClN3O2/c1-4-12-16(9(2)24-22-12)11-7-14-10(8-15(11)23-3)17-13(21-14)5-6-20-18(17)19/h5-8,21H,4H2,1-3H3
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1.24E+3 -33.7n/an/an/an/an/an/a25



The Regents of the University of Michigan

US Patent


Assay Description
Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...


US Patent US9675697 (2017)


Article DOI: 10.1021/jm970615f
BindingDB Entry DOI: 10.7270/Q2CC0XV6
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM50092339
PNG
(CHEMBL3581648 | US9675697, RX-7)
Show SMILES COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ccncc21
Show InChI InChI=1S/C17H15N3O2/c1-9-17(10(2)22-20-9)12-6-15-11(7-16(12)21-3)13-8-18-5-4-14(13)19-15/h4-8,19H,1-3H3
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1.64E+3 -33.0n/an/an/an/an/an/a25



The Regents of the University of Michigan

US Patent


Assay Description
Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...


US Patent US9675697 (2017)


Article DOI: 10.1021/jm970615f
BindingDB Entry DOI: 10.7270/Q2CC0XV6
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM179475
PNG
(US9675697, Cpd. No. 33)
Show SMILES COc1cc2c(cc1-c1c(C)nnc1C)[nH]c1ccnc(Cl)c21
Show InChI InChI=1S/C17H13ClN4O/c1-8-15(9(2)22-21-8)11-6-13-10(7-14(11)23-3)16-12(20-13)4-5-19-17(16)18/h4-7H,1-3H3
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1.73E+3 -32.9n/an/an/an/an/an/a25



The Regents of the University of Michigan

US Patent


Assay Description
Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...


US Patent US9675697 (2017)


Article DOI: 10.1021/jm970615f
BindingDB Entry DOI: 10.7270/Q2CC0XV6
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM186321
PNG
(US9675697, RX-38)
Show SMILES CCc1onc(C)c1-c1cc2[nH]c3ccnc(Cl)c3c2cc1OC
Show InChI InChI=1S/C18H16ClN3O2/c1-4-14-16(9(2)22-24-14)11-7-13-10(8-15(11)23-3)17-12(21-13)5-6-20-18(17)19/h5-8,21H,4H2,1-3H3
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2.81E+3 -31.7n/an/an/an/an/an/a25



The Regents of the University of Michigan

US Patent


Assay Description
Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...


US Patent US9675697 (2017)


Article DOI: 10.1021/jm970615f
BindingDB Entry DOI: 10.7270/Q2CC0XV6
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM50092325
PNG
(CHEMBL3581654 | US9675697, RX-27)
Show SMILES COc1cc2c(cc1-c1c(C)nn(C)c1C)[nH]c1ccnc(Cl)c21
Show InChI InChI=1S/C18H17ClN4O/c1-9-16(10(2)23(3)22-9)12-7-14-11(8-15(12)24-4)17-13(21-14)5-6-20-18(17)19/h5-8,21H,1-4H3
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4.84E+3 -30.3n/an/an/an/an/an/a25



The Regents of the University of Michigan

US Patent


Assay Description
Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...


US Patent US9675697 (2017)


Article DOI: 10.1021/jm970615f
BindingDB Entry DOI: 10.7270/Q2CC0XV6
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM50092327
PNG
(CHEMBL3581652 | US9675697, RX-45)
Show SMILES CCc1noc(CC)c1-c1cc2[nH]c3ccnc(Cl)c3c2cc1OC
Show InChI InChI=1S/C19H18ClN3O2/c1-4-12-17(15(5-2)25-23-12)11-8-14-10(9-16(11)24-3)18-13(22-14)6-7-21-19(18)20/h6-9,22H,4-5H2,1-3H3
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>1.00E+4>-28.5n/an/an/an/an/an/a25



The Regents of the University of Michigan

US Patent


Assay Description
Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...


US Patent US9675697 (2017)


Article DOI: 10.1021/jm970615f
BindingDB Entry DOI: 10.7270/Q2CC0XV6
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM249297
PNG
(US10017501, Compound 1020-102 | US9458145, 1020-10...)
Show SMILES Cc1noc(C)c1-c1cc(c2nc([nH]c2c1)C1CC1)C(O)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C28H25N3O2/c1-17-25(18(2)33-31-17)20-15-23(26-24(16-20)29-27(30-26)19-13-14-19)28(32,21-9-5-3-6-10-21)22-11-7-4-8-12-22/h3-12,15-16,19,32H,13-14H2,1-2H3,(H,29,30)
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n/an/a 14.3n/an/an/an/a7.525



Gilead Sciences Inc

US Patent


Assay Description
Binding of the bromodomain BRD4-I to an acetylated histone H4 peptide was measured using a bead-based Amplified Luminescent Proximity Homogeneous Ass...


US Patent US9458145 (2016)


BindingDB Entry DOI: 10.7270/Q26Q1W53
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM249298
PNG
(US10017501, Compound 1020-120 | US9458145, 1020-12...)
Show SMILES CCC(CC)c1cc(cc2[nH]c(nc12)C1CC1)-c1c(C)noc1C
Show InChI InChI=1S/C20H25N3O/c1-5-13(6-2)16-9-15(18-11(3)23-24-12(18)4)10-17-19(16)22-20(21-17)14-7-8-14/h9-10,13-14H,5-8H2,1-4H3,(H,21,22)
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n/an/a 39.7n/an/an/an/a7.525



Gilead Sciences Inc

US Patent


Assay Description
Binding of the bromodomain BRD4-I to an acetylated histone H4 peptide was measured using a bead-based Amplified Luminescent Proximity Homogeneous Ass...


US Patent US9458145 (2016)


BindingDB Entry DOI: 10.7270/Q26Q1W53
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM249299
PNG
(US10017501, Compound 1020-121 | US9458145, 1020-12...)
Show SMILES Cc1noc(C)c1-c1cc(C(O)C2CCCC2)c2nc([nH]c2c1)C1CC1
Show InChI InChI=1/C21H25N3O2/c1-11-18(12(2)26-24-11)15-9-16(20(25)13-5-3-4-6-13)19-17(10-15)22-21(23-19)14-7-8-14/h9-10,13-14,20,25H,3-8H2,1-2H3,(H,22,23)
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n/an/a 24.7n/an/an/an/a7.525



Gilead Sciences Inc

US Patent


Assay Description
Binding of the bromodomain BRD4-I to an acetylated histone H4 peptide was measured using a bead-based Amplified Luminescent Proximity Homogeneous Ass...


US Patent US9458145 (2016)


BindingDB Entry DOI: 10.7270/Q26Q1W53
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM249300
PNG
(US10017501, Compound 1020-132 | US9458145, 1020-13...)
Show SMILES CCC(O)(CC)c1cc(cc2n(C)c(nc12)C1CC1)-c1c(C)noc1C
Show InChI InChI=1S/C21H27N3O2/c1-6-21(25,7-2)16-10-15(18-12(3)23-26-13(18)4)11-17-19(16)22-20(24(17)5)14-8-9-14/h10-11,14,25H,6-9H2,1-5H3
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n/an/a 573n/an/an/an/a7.525



Gilead Sciences Inc

US Patent


Assay Description
Binding of the bromodomain BRD4-I to an acetylated histone H4 peptide was measured using a bead-based Amplified Luminescent Proximity Homogeneous Ass...


US Patent US9458145 (2016)


BindingDB Entry DOI: 10.7270/Q26Q1W53
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM249301
PNG
(US10017501, Compound 1020-136 | US9458145, 1020-13...)
Show SMILES CC1CCC(=O)N1c1cc(cc2[nH]c(nc12)C1CC1)-c1c(C)noc1C
Show InChI InChI=1/C20H22N4O2/c1-10-4-7-17(25)24(10)16-9-14(18-11(2)23-26-12(18)3)8-15-19(16)22-20(21-15)13-5-6-13/h8-10,13H,4-7H2,1-3H3,(H,21,22)
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n/an/a 513n/an/an/an/a7.525



Gilead Sciences Inc

US Patent


Assay Description
Binding of the bromodomain BRD4-I to an acetylated histone H4 peptide was measured using a bead-based Amplified Luminescent Proximity Homogeneous Ass...


US Patent US9458145 (2016)


BindingDB Entry DOI: 10.7270/Q26Q1W53
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM249302
PNG
(US10017501, Compound 1020-137 | US9458145, 1020-13...)
Show SMILES CCC1CCC(=O)N1c1cc(cc2[nH]c(nc12)C1CC1)-c1c(C)noc1C
Show InChI InChI=1/C21H24N4O2/c1-4-15-7-8-18(26)25(15)17-10-14(19-11(2)24-27-12(19)3)9-16-20(17)23-21(22-16)13-5-6-13/h9-10,13,15H,4-8H2,1-3H3,(H,22,23)
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n/an/a 52.8n/an/an/an/a7.525



Gilead Sciences Inc

US Patent


Assay Description
Binding of the bromodomain BRD4-I to an acetylated histone H4 peptide was measured using a bead-based Amplified Luminescent Proximity Homogeneous Ass...


US Patent US9458145 (2016)


BindingDB Entry DOI: 10.7270/Q26Q1W53
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM249305
PNG
(US10017501, Compound 1020-103 | US9458145, 1020-10...)
Show SMILES Cc1noc(C)c1-c1cc(c2nc([nH]c2c1)C1CC1)C(O)(c1nccs1)c1nccs1
Show InChI InChI=1S/C22H19N5O2S2/c1-11-17(12(2)29-27-11)14-9-15(18-16(10-14)25-19(26-18)13-3-4-13)22(28,20-23-5-7-30-20)21-24-6-8-31-21/h5-10,13,28H,3-4H2,1-2H3,(H,25,26)
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n/an/a 4n/an/an/an/a7.525



Gilead Sciences Inc

US Patent


Assay Description
The labeled ligand specifically binds BRD4-1 and BRD4-2 and can be displaced by a small molecule inhibitor that shares a similar or overlapping bindi...


US Patent US9458145 (2016)


BindingDB Entry DOI: 10.7270/Q26Q1W53
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM249306
PNG
(US10017501, Compound 1020-104 | US9458145, 1020-10...)
Show SMILES Cc1noc(C)c1-c1cc(c2nc([nH]c2c1)C1CC1)C(O)(c1ccccn1)c1ccccn1
Show InChI InChI=1S/C26H23N5O2/c1-15-23(16(2)33-31-15)18-13-19(24-20(14-18)29-25(30-24)17-9-10-17)26(32,21-7-3-5-11-27-21)22-8-4-6-12-28-22/h3-8,11-14,17,32H,9-10H2,1-2H3,(H,29,30)
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US Patent
n/an/a 7.20n/an/an/an/a7.525



Gilead Sciences Inc

US Patent


Assay Description
The labeled ligand specifically binds BRD4-1 and BRD4-2 and can be displaced by a small molecule inhibitor that shares a similar or overlapping bindi...


US Patent US9458145 (2016)


BindingDB Entry DOI: 10.7270/Q26Q1W53
More data for this
Ligand-Target Pair
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