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Compile Data Set for Download or QSAR

Found 118 hits Enz. Inhib. hit(s) with Target = 'CDK8/Cyclin C'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM50154938
PNG
(CHEMBL3774874)
Show SMILES CNC(=O)c1ccc2[nH]nc(CC(C)C)c2c1
Show InChI InChI=1S/C13H17N3O/c1-8(2)6-12-10-7-9(13(17)14-3)4-5-11(10)15-16-12/h4-5,7-8H,6H2,1-3H3,(H,14,17)(H,15,16)
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n/an/a 840n/an/an/an/an/an/a



Merck KGaA

Curated by ChEMBL


Assay Description
Displacement of dye-labeled ATP competitive probe from recombinant human CDK8/Cyclin C incubated for 20 mins by Alexa647 probe-based FRET assay


Bioorg Med Chem Lett 26: 1443-51 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.062
BindingDB Entry DOI: 10.7270/Q2NZ89G6
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350169
PNG
(US10208056, Compound 1)
Show SMILES CC1(C)Oc2cnccc2-c2[nH]c(cc12)C(N)=O
Show InChI InChI=1S/C13H13N3O2/c1-13(2)8-5-9(12(14)17)16-11(8)7-3-4-15-6-10(7)18-13/h3-6,16H,1-2H3,(H2,14,17)
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n/an/a 2.59n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350170
PNG
(US10208056, Compound 2)
Show SMILES CC1(C)Oc2cnccc2-c2[nH]c(cc12)C(O)=O
Show InChI InChI=1S/C13H12N2O3/c1-13(2)8-5-9(12(16)17)15-11(8)7-3-4-14-6-10(7)18-13/h3-6,15H,1-2H3,(H,16,17)
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n/an/a 146n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350171
PNG
(US10208056, Compound 3)
Show SMILES CNC(=O)c1cc2c([nH]1)-c1ccncc1OC2(C)C
Show InChI InChI=1S/C14H15N3O2/c1-14(2)9-6-10(13(18)15-3)17-12(9)8-4-5-16-7-11(8)19-14/h4-7,17H,1-3H3,(H,15,18)
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n/an/a 92.2n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350172
PNG
(US10208056, Compound 4)
Show SMILES CC1(C)Oc2cnccc2-c2[nH]c(cc12)C(=O)Nc1ccccc1
Show InChI InChI=1S/C19H17N3O2/c1-19(2)14-10-15(18(23)21-12-6-4-3-5-7-12)22-17(14)13-8-9-20-11-16(13)24-19/h3-11,22H,1-2H3,(H,21,23)
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n/an/a 5.28E+3n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350173
PNG
(US10208056, Compound 5)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)NC(=O)c1cc2c([nH]1)-c1ccncc1OC2(C)C
Show InChI InChI=1S/C23H30N4O4/c1-22(2,3)31-21(29)27-10-7-14(8-11-27)25-20(28)17-12-16-19(26-17)15-6-9-24-13-18(15)30-23(16,4)5/h6,9,12-14,26H,7-8,10-11H2,1-5H3,(H,25,28)
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n/an/a 1.87E+3n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350174
PNG
(US10208056, Compound 6)
Show SMILES CC(C)NC(=O)c1cc2c([nH]1)-c1ccncc1OC2(C)C
Show InChI InChI=1S/C16H19N3O2/c1-9(2)18-15(20)12-7-11-14(19-12)10-5-6-17-8-13(10)21-16(11,3)4/h5-9,19H,1-4H3,(H,18,20)
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n/an/a 2.41E+3n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350175
PNG
(US10208056, Compound 7)
Show SMILES COCCNC(=O)c1cc2c([nH]1)-c1ccncc1OC2(C)C
Show InChI InChI=1S/C16H19N3O3/c1-16(2)11-8-12(15(20)18-6-7-21-3)19-14(11)10-4-5-17-9-13(10)22-16/h4-5,8-9,19H,6-7H2,1-3H3,(H,18,20)
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n/an/a 1.49E+3n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350176
PNG
(US10208056, Compound 8)
Show SMILES CC1(C)Oc2cnccc2-c2[nH]c(cc12)C(=O)NCc1ccccc1
Show InChI InChI=1S/C20H19N3O2/c1-20(2)15-10-16(19(24)22-11-13-6-4-3-5-7-13)23-18(15)14-8-9-21-12-17(14)25-20/h3-10,12,23H,11H2,1-2H3,(H,22,24)
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n/an/a 340n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350177
PNG
(US10208056, Compound 9)
Show SMILES CCN(CC)C(=O)c1cc2c([nH]1)-c1ccncc1OC2(C)C
Show InChI InChI=1S/C17H21N3O2/c1-5-20(6-2)16(21)13-9-12-15(19-13)11-7-8-18-10-14(11)22-17(12,3)4/h7-10,19H,5-6H2,1-4H3
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n/an/a 979n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350178
PNG
(US10208056, Compound 10)
Show SMILES CC1(C)Oc2cnccc2-c2[nH]c(cc12)C(=O)NC1CCNCC1
Show InChI InChI=1S/C18H22N4O2/c1-18(2)13-9-14(17(23)21-11-3-6-19-7-4-11)22-16(13)12-5-8-20-10-15(12)24-18/h5,8-11,19,22H,3-4,6-7H2,1-2H3,(H,21,23)
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n/an/a 3.52E+3n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350179
PNG
(US10208056, Compound 11)
Show SMILES CC1(C)Oc2cnccc2-c2[nH]c(cc12)C(=O)NCCc1ccccc1
Show InChI InChI=1S/C21H21N3O2/c1-21(2)16-12-17(20(25)23-11-8-14-6-4-3-5-7-14)24-19(16)15-9-10-22-13-18(15)26-21/h3-7,9-10,12-13,24H,8,11H2,1-2H3,(H,23,25)
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n/an/a 162n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350180
PNG
(US10208056, Compound 12)
Show SMILES NC(=O)c1cc2c([nH]1)-c1ccncc1OC21CCNCC1
Show InChI InChI=1S/C15H16N4O2/c16-14(20)11-7-10-13(19-11)9-1-4-18-8-12(9)21-15(10)2-5-17-6-3-15/h1,4,7-8,17,19H,2-3,5-6H2,(H2,16,20)
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n/an/a 412n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350181
PNG
(US10208056, Compound 13)
Show SMILES NC(=O)c1cc2c([nH]1)-c1ccncc1OC21CCCCC1
Show InChI InChI=1S/C16H17N3O2/c17-15(20)12-8-11-14(19-12)10-4-7-18-9-13(10)21-16(11)5-2-1-3-6-16/h4,7-9,19H,1-3,5-6H2,(H2,17,20)
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n/an/a 4.18n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350182
PNG
(US10208056, Compound 14)
Show SMILES OC(=O)c1cc2c([nH]1)-c1ccncc1OC21CCCCC1
Show InChI InChI=1S/C16H16N2O3/c19-15(20)12-8-11-14(18-12)10-4-7-17-9-13(10)21-16(11)5-2-1-3-6-16/h4,7-9,18H,1-3,5-6H2,(H,19,20)
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n/an/a 23.9n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350183
PNG
(US10208056, Compound 15)
Show SMILES NC(=O)c1cc2c([nH]1)-c1ccncc1OC21CCC1
Show InChI InChI=1S/C14H13N3O2/c15-13(18)10-6-9-12(17-10)8-2-5-16-7-11(8)19-14(9)3-1-4-14/h2,5-7,17H,1,3-4H2,(H2,15,18)
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n/an/a 1.96n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350184
PNG
(US10208056, Compound 16)
Show SMILES NC(=O)c1cc2c([nH]1)-c1ccncc1OC21CCN(CC1)C1CC1
Show InChI InChI=1S/C18H20N4O2/c19-17(23)14-9-13-16(21-14)12-3-6-20-10-15(12)24-18(13)4-7-22(8-5-18)11-1-2-11/h3,6,9-11,21H,1-2,4-5,7-8H2,(H2,19,23)
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n/an/a 5.70E+3n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350185
PNG
(US10208056, Compound 17)
Show SMILES OC(=O)c1cc2c([nH]1)-c1ccncc1OC21CCN(CC1)C1CC1
Show InChI InChI=1S/C18H19N3O3/c22-17(23)14-9-13-16(20-14)12-3-6-19-10-15(12)24-18(13)4-7-21(8-5-18)11-1-2-11/h3,6,9-11,20H,1-2,4-5,7-8H2,(H,22,23)
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n/an/a 1.53E+3n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350186
PNG
(US10208056, Compound 18)
Show SMILES NC(=O)c1cc2c([nH]1)-c1ccncc1OC21CCN(CC(F)(F)F)CC1
Show InChI InChI=1S/C17H17F3N4O2/c18-17(19,20)9-24-5-2-16(3-6-24)11-7-12(15(21)25)23-14(11)10-1-4-22-8-13(10)26-16/h1,4,7-8,23H,2-3,5-6,9H2,(H2,21,25)
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n/an/a 20.2n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350187
PNG
(US10208056, Compound 19)
Show SMILES OC(=O)c1cc2c([nH]1)-c1ccncc1OC21CCN(CC(F)(F)F)CC1
Show InChI InChI=1S/C17H16F3N3O3/c18-17(19,20)9-23-5-2-16(3-6-23)11-7-12(15(24)25)22-14(11)10-1-4-21-8-13(10)26-16/h1,4,7-8,22H,2-3,5-6,9H2,(H,24,25)
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n/an/a 652n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350188
PNG
(US10208056, Compound 20)
Show SMILES NC(=O)c1cc2c([nH]1)-c1ccncc1OC21CCOCC1
Show InChI InChI=1S/C15H15N3O3/c16-14(19)11-7-10-13(18-11)9-1-4-17-8-12(9)21-15(10)2-5-20-6-3-15/h1,4,7-8,18H,2-3,5-6H2,(H2,16,19)
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n/an/a 54.7n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350189
PNG
(US10208056, Compound 21)
Show SMILES CC1(C)Oc2cnccc2-c2[nH]c(cc12)C(=O)N1CCOCC1
Show InChI InChI=1S/C17H19N3O3/c1-17(2)12-9-13(16(21)20-5-7-22-8-6-20)19-15(12)11-3-4-18-10-14(11)23-17/h3-4,9-10,19H,5-8H2,1-2H3
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n/an/a 671n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350190
PNG
(US10208056, Compound 22)
Show SMILES Cn1c(cc2c1-c1ccncc1OC2(C)C)C(N)=O
Show InChI InChI=1S/C14H15N3O2/c1-14(2)9-6-10(13(15)18)17(3)12(9)8-4-5-16-7-11(8)19-14/h4-7H,1-3H3,(H2,15,18)
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n/an/a 1.98n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350191
PNG
(US10208056, Compound 23)
Show SMILES Cn1c(cc2c1-c1ccncc1OC2(C)C)C(O)=O
Show InChI InChI=1S/C14H14N2O3/c1-14(2)9-6-10(13(17)18)16(3)12(9)8-4-5-15-7-11(8)19-14/h4-7H,1-3H3,(H,17,18)
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n/an/a 61.1n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350192
PNG
(US10208056, Compound 24)
Show SMILES CC1(C)Oc2cnccc2-c2c1cc(C(O)=O)n2Cc1ccccc1
Show InChI InChI=1S/C20H18N2O3/c1-20(2)15-10-16(19(23)24)22(12-13-6-4-3-5-7-13)18(15)14-8-9-21-11-17(14)25-20/h3-11H,12H2,1-2H3,(H,23,24)
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n/an/a 1.00E+4n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350193
PNG
(US10208056, Compound 25)
Show SMILES CC(C)n1c(cc2c1-c1ccncc1OC2(C)C)C(N)=O
Show InChI InChI=1S/C16H19N3O2/c1-9(2)19-12(15(17)20)7-11-14(19)10-5-6-18-8-13(10)21-16(11,3)4/h5-9H,1-4H3,(H2,17,20)
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n/an/a 5.87E+3n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350194
PNG
(US10208056, Compound 26)
Show SMILES CC(C)n1c(cc2c1-c1ccncc1OC2(C)C)C(O)=O
Show InChI InChI=1S/C16H18N2O3/c1-9(2)18-12(15(19)20)7-11-14(18)10-5-6-17-8-13(10)21-16(11,3)4/h5-9H,1-4H3,(H,19,20)
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n/an/a 5.94E+3n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350195
PNG
(US10208056, Compound 27)
Show SMILES COCCn1c(cc2c1-c1ccncc1OC2(C)C)C(O)=O
Show InChI InChI=1S/C16H18N2O4/c1-16(2)11-8-12(15(19)20)18(6-7-21-3)14(11)10-4-5-17-9-13(10)22-16/h4-5,8-9H,6-7H2,1-3H3,(H,19,20)
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n/an/a 1.00E+4n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350196
PNG
(US10208056, Compound 28)
Show SMILES CC1(C)Oc2cnccc2-c2[nH]c(C(N)=O)c(Cl)c12
Show InChI InChI=1S/C13H12ClN3O2/c1-13(2)8-9(14)11(12(15)18)17-10(8)6-3-4-16-5-7(6)19-13/h3-5,17H,1-2H3,(H2,15,18)
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n/an/a 9.32n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350197
PNG
(US10208056, Compound 29)
Show SMILES CC1(C)Oc2cnccc2-c2[nH]c(C(O)=O)c(Br)c12
Show InChI InChI=1S/C13H11BrN2O3/c1-13(2)8-9(14)11(12(17)18)16-10(8)6-3-4-15-5-7(6)19-13/h3-5,16H,1-2H3,(H,17,18)
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n/an/a 52.5n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350198
PNG
(US10208056, Compound 30)
Show SMILES CC1(C)Oc2cnccc2-c2[nH]c(C(O)=O)c(c12)-c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C19H17N3O5S/c1-19(2)15-14(10-3-5-11(6-4-10)28(20,25)26)17(18(23)24)22-16(15)12-7-8-21-9-13(12)27-19/h3-9,22H,1-2H3,(H,23,24)(H2,20,25,26)
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n/an/a 8.94n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350199
PNG
(US10208056, Compound 31)
Show SMILES CC1(C)Oc2cnccc2-c2[nH]c(C(N)=O)c(c12)-c1ccccc1
Show InChI InChI=1S/C19H17N3O2/c1-19(2)15-14(11-6-4-3-5-7-11)17(18(20)23)22-16(15)12-8-9-21-10-13(12)24-19/h3-10,22H,1-2H3,(H2,20,23)
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n/an/a 29.7n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350200
PNG
(US10208056, Compound 32)
Show SMILES CC1(C)Oc2cnccc2-c2[nH]c(C(N)=O)c(c12)-c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C19H18N4O4S/c1-19(2)15-14(10-3-5-11(6-4-10)28(21,25)26)17(18(20)24)23-16(15)12-7-8-22-9-13(12)27-19/h3-9,23H,1-2H3,(H2,20,24)(H2,21,25,26)
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n/an/a 26.2n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350201
PNG
(US10208056, Compound 33)
Show SMILES CC1(C)Oc2cnccc2-c2[nH]c(C(N)=O)c(C=C)c12
Show InChI InChI=1S/C15H15N3O2/c1-4-8-11-12(18-13(8)14(16)19)9-5-6-17-7-10(9)20-15(11,2)3/h4-7,18H,1H2,2-3H3,(H2,16,19)
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n/an/a 12.3n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350202
PNG
(US10208056, Compound 34)
Show SMILES CC1(C)Oc2cncc(Cl)c2-c2[nH]c(cc12)C(N)=O
Show InChI InChI=1S/C13H12ClN3O2/c1-13(2)6-3-8(12(15)18)17-11(6)10-7(14)4-16-5-9(10)19-13/h3-5,17H,1-2H3,(H2,15,18)
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n/an/a 2.10n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350203
PNG
(US10208056, Compound 35)
Show SMILES CC1(C)Oc2cncc(Cl)c2-c2[nH]c(cc12)C(O)=O
Show InChI InChI=1S/C13H11ClN2O3/c1-13(2)6-3-8(12(17)18)16-11(6)10-7(14)4-15-5-9(10)19-13/h3-5,16H,1-2H3,(H,17,18)
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n/an/a 13.3n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350204
PNG
(US10208056, Compound 36)
Show SMILES CC1(C)Oc2c(Cl)nccc2-c2[nH]c(cc12)C(N)=O
Show InChI InChI=1S/C13H12ClN3O2/c1-13(2)7-5-8(12(15)18)17-9(7)6-3-4-16-11(14)10(6)19-13/h3-5,17H,1-2H3,(H2,15,18)
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n/an/a 559n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350205
PNG
(US10208056, Compound 37)
Show SMILES CC1(C)Oc2c(Cl)nccc2-c2[nH]c(cc12)C(O)=O
Show InChI InChI=1S/C13H11ClN2O3/c1-13(2)7-5-8(12(17)18)16-9(7)6-3-4-15-11(14)10(6)19-13/h3-5,16H,1-2H3,(H,17,18)
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n/an/a 6.29E+3n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350206
PNG
(US10208056, Compound 38)
Show SMILES CC1(C)Oc2cnc(Cl)cc2-c2[nH]c(cc12)C(N)=O
Show InChI InChI=1S/C13H12ClN3O2/c1-13(2)7-4-8(12(15)18)17-11(7)6-3-10(14)16-5-9(6)19-13/h3-5,17H,1-2H3,(H2,15,18)
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n/an/a 461n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350207
PNG
(US10208056, Compound 39)
Show SMILES CC1(C)Oc2cncc(-c3ccccc3)c2-c2[nH]c(cc12)C(N)=O
Show InChI InChI=1S/C19H17N3O2/c1-19(2)13-8-14(18(20)23)22-17(13)16-12(9-21-10-15(16)24-19)11-6-4-3-5-7-11/h3-10,22H,1-2H3,(H2,20,23)
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n/an/a 206n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350208
PNG
(US10208056, Compound 40)
Show SMILES CC1(C)Oc2cnccc2-c2[nH]c(C(N)=O)c(c12)-c1cccc(c1)S(N)(=O)=O
Show InChI InChI=1S/C19H18N4O4S/c1-19(2)15-14(10-4-3-5-11(8-10)28(21,25)26)17(18(20)24)23-16(15)12-6-7-22-9-13(12)27-19/h3-9,23H,1-2H3,(H2,20,24)(H2,21,25,26)
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n/an/a 269n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350209
PNG
(US10208056, Compound 41)
Show SMILES Cn1c(cc2c1-c1c(Cl)cncc1OC2(C)C)C(N)=O
Show InChI InChI=1S/C14H14ClN3O2/c1-14(2)7-4-9(13(16)19)18(3)12(7)11-8(15)5-17-6-10(11)20-14/h4-6H,1-3H3,(H2,16,19)
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n/an/a 55.5n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350210
PNG
(US10208056, Compound 42)
Show SMILES CCN1CCC2(CC1)Oc1cnccc1-c1[nH]c(cc21)C(N)=O
Show InChI InChI=1S/C17H20N4O2/c1-2-21-7-4-17(5-8-21)12-9-13(16(18)22)20-15(12)11-3-6-19-10-14(11)23-17/h3,6,9-10,20H,2,4-5,7-8H2,1H3,(H2,18,22)
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n/an/a 197n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350211
PNG
(US10208056, Compound 43)
Show SMILES CCn1c(cc2c1-c1ccncc1OC2(C)C)C(N)=O
Show InChI InChI=1S/C15H17N3O2/c1-4-18-11(14(16)19)7-10-13(18)9-5-6-17-8-12(9)20-15(10,2)3/h5-8H,4H2,1-3H3,(H2,16,19)
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n/an/a 1.41n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350212
PNG
(US10208056, Compound 44)
Show SMILES CCn1c(cc2c1-c1ccncc1OC2(C)C)C(O)=O
Show InChI InChI=1S/C15H16N2O3/c1-4-17-11(14(18)19)7-10-13(17)9-5-6-16-8-12(9)20-15(10,2)3/h5-8H,4H2,1-3H3,(H,18,19)
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n/an/a 312n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350213
PNG
(US10208056, Compound 45)
Show SMILES COCCn1c(cc2c1-c1ccncc1OC2(C)C)C(N)=O
Show InChI InChI=1S/C16H19N3O3/c1-16(2)11-8-12(15(17)20)19(6-7-21-3)14(11)10-4-5-18-9-13(10)22-16/h4-5,8-9H,6-7H2,1-3H3,(H2,17,20)
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n/an/a 4.64n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350214
PNG
(US10208056, Compound 46)
Show SMILES NC(=O)c1cc2c([nH]1)-c1ccncc1OC21CCN(CCc2ccccc2)CC1
Show InChI InChI=1S/C23H24N4O2/c24-22(28)19-14-18-21(26-19)17-6-10-25-15-20(17)29-23(18)8-12-27(13-9-23)11-7-16-4-2-1-3-5-16/h1-6,10,14-15,26H,7-9,11-13H2,(H2,24,28)
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n/an/a 445n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350215
PNG
(US10208056, Compound 47)
Show SMILES NC(=O)c1cc2c([nH]1)-c1ccncc1OC21CCN(CCC(F)(F)F)CC1
Show InChI InChI=1S/C18H19F3N4O2/c19-18(20,21)4-8-25-6-2-17(3-7-25)12-9-13(16(22)26)24-15(12)11-1-5-23-10-14(11)27-17/h1,5,9-10,24H,2-4,6-8H2,(H2,22,26)
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n/an/a 120n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350216
PNG
(US10208056, Compound 48)
Show SMILES NC(=O)c1cc2c([nH]1)-c1ccncc1OC21CCN(CCCC(F)(F)F)CC1
Show InChI InChI=1S/C19H21F3N4O2/c20-19(21,22)3-1-7-26-8-4-18(5-9-26)13-10-14(17(23)27)25-16(13)12-2-6-24-11-15(12)28-18/h2,6,10-11,25H,1,3-5,7-9H2,(H2,23,27)
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n/an/a 886n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350217
PNG
(US10208056, Compound 49)
Show SMILES CC1(COC1)C1(C)Oc2cnccc2-c2[nH]c(cc12)C(N)=O
Show InChI InChI=1/C16H17N3O3/c1-15(7-21-8-15)16(2)10-5-11(14(17)20)19-13(10)9-3-4-18-6-12(9)22-16/h3-6,19H,7-8H2,1-2H3,(H2,17,20)
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n/an/a 315n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent


Assay Description
The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...


US Patent US10208056 (2019)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2GB266B
More data for this
Ligand-Target Pair
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