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Compile Data Set for Download or QSAR

Found 915 hits Enz. Inhib. hit(s) with Target = 'CREB-binding protein'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
CREB-binding protein


(Homo sapiens (Human))
BDBM50151662
PNG
(CHEMBL3775371)
Show SMILES C[C@@H](Cn1c(CCc2ccccc2)nc2cc(ccc12)-c1c(C)noc1C)N1CCOCC1
Show InChI InChI=1S/C27H32N4O2/c1-19(30-13-15-32-16-14-30)18-31-25-11-10-23(27-20(2)29-33-21(27)3)17-24(25)28-26(31)12-9-22-7-5-4-6-8-22/h4-8,10-11,17,19H,9,12-16,18H2,1-3H3/t19-/m0/s1
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n/an/an/a 21n/an/an/an/an/a



University of Freiburg

Curated by ChEMBL


Assay Description
Inhibition of human CREBBP expressed in competent escherichia coli BL21(DE3)-R3-pRARE2 cells by isothermal titration calorimetry


J Med Chem 59: 1249-70 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01502
BindingDB Entry DOI: 10.7270/Q2DV1MRN
More data for this
Ligand-Target Pair
CREB-binding protein/Histone acetyltransferase p300


(Homo sapiens (Human))
BDBM188519
PNG
(SGC-CBP30)
Show SMILES COc1ccc(CCc2nc3cc(ccc3n2C[C@H](C)N2CCOCC2)-c2c(C)noc2C)cc1Cl
Show InChI InChI=1S/C28H33ClN4O3/c1-18(32-11-13-35-14-12-32)17-33-25-8-7-22(28-19(2)31-36-20(28)3)16-24(25)30-27(33)10-6-21-5-9-26(34-4)23(29)15-21/h5,7-9,15-16,18H,6,10-14,17H2,1-4H3/t18-/m0/s1
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n/an/an/a 21n/an/an/an/an/a



Ludwig-Maximilians-Universit£t M£nchen

Curated by ChEMBL


Assay Description
Binding affinity to human N-terminal His10-tagged/C-terminal Biotin-tagged CBP (R1081 to G1198 residues)/P300 expressed in Escherichia coli BL21(DE3)...


J Med Chem 59: 8889-8912 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00774
BindingDB Entry DOI: 10.7270/Q2736SVT
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
CREB-binding protein


(Homo sapiens (Human))
BDBM188519
PNG
(SGC-CBP30)
Show SMILES COc1ccc(CCc2nc3cc(ccc3n2C[C@H](C)N2CCOCC2)-c2c(C)noc2C)cc1Cl
Show InChI InChI=1S/C28H33ClN4O3/c1-18(32-11-13-35-14-12-32)17-33-25-8-7-22(28-19(2)31-36-20(28)3)16-24(25)30-27(33)10-6-21-5-9-26(34-4)23(29)15-21/h5,7-9,15-16,18H,6,10-14,17H2,1-4H3/t18-/m0/s1
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n/an/an/a 21n/an/an/an/an/a



Pfizer



Assay Description
Experiments were performed using recombinant CBP and BRD4 bromodomainsusing the procedure reported recently (Hett et al., 2015).


Chem Biol 22: 1588-96 (2015)


Article DOI: 10.1016/j.chembiol.2015.10.013
BindingDB Entry DOI: 10.7270/Q2V69HC0
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
CREB-binding protein


(Homo sapiens (Human))
BDBM188519
PNG
(SGC-CBP30)
Show SMILES COc1ccc(CCc2nc3cc(ccc3n2C[C@H](C)N2CCOCC2)-c2c(C)noc2C)cc1Cl
Show InChI InChI=1S/C28H33ClN4O3/c1-18(32-11-13-35-14-12-32)17-33-25-8-7-22(28-19(2)31-36-20(28)3)16-24(25)30-27(33)10-6-21-5-9-26(34-4)23(29)15-21/h5,7-9,15-16,18H,6,10-14,17H2,1-4H3/t18-/m0/s1
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n/an/an/a 21n/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Binding affinity to human CBP by isothermal titration calorimetric analysis


J Med Chem 59: 1271-98 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01514
BindingDB Entry DOI: 10.7270/Q2X92D6H
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
CREB-binding protein


(Homo sapiens (Human))
BDBM188519
PNG
(SGC-CBP30)
Show SMILES COc1ccc(CCc2nc3cc(ccc3n2C[C@H](C)N2CCOCC2)-c2c(C)noc2C)cc1Cl
Show InChI InChI=1S/C28H33ClN4O3/c1-18(32-11-13-35-14-12-32)17-33-25-8-7-22(28-19(2)31-36-20(28)3)16-24(25)30-27(33)10-6-21-5-9-26(34-4)23(29)15-21/h5,7-9,15-16,18H,6,10-14,17H2,1-4H3/t18-/m0/s1
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n/an/an/a 21n/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Binding affinity to human CBP by ITC analysis


J Med Chem 58: 7611-33 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00229
BindingDB Entry DOI: 10.7270/Q2QZ2CSD
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
CREB-binding protein


(Homo sapiens (Human))
BDBM50178219
PNG
(CHEMBL3814752)
Show SMILES C[C@@H]1CC(=O)Nc2cccc(-c3ccc4n(C)nc(-c5cnn(C)c5)c4c3)c2N1
Show InChI InChI=1S/C22H22N6O/c1-13-9-20(29)25-18-6-4-5-16(22(18)24-13)14-7-8-19-17(10-14)21(26-28(19)3)15-11-23-27(2)12-15/h4-8,10-13,24H,9H2,1-3H3,(H,25,29)/t13-/m1/s1
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n/an/an/a 30n/an/an/an/an/a



Constellation Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity to human CBP at 17 uM by isothermal titration calorimetry


ACS Med Chem Lett 7: 531-6 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00075
BindingDB Entry DOI: 10.7270/Q20G3N3S
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
CREB-binding protein


(Homo sapiens (Human))
BDBM188516
PNG
(BDOIA383)
Show SMILES COc1ccc(CCc2nc3cc(ccc3n2CCN2CCOCC2)-c2c(C)noc2C)cc1
Show InChI InChI=1S/C27H32N4O3/c1-19-27(20(2)34-29-19)22-7-10-25-24(18-22)28-26(11-6-21-4-8-23(32-3)9-5-21)31(25)13-12-30-14-16-33-17-15-30/h4-5,7-10,18H,6,11-17H2,1-3H3
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n/an/an/a 120n/an/an/an/an/a



Pfizer



Assay Description
Experiments were performed using recombinant CBP and BRD4 bromodomainsusing the procedure reported recently (Hett et al., 2015).


Chem Biol 22: 1588-96 (2015)


Article DOI: 10.1016/j.chembiol.2015.10.013
BindingDB Entry DOI: 10.7270/Q2V69HC0
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
CREB-binding protein/Histone acetyltransferase p300


(Homo sapiens (Human))
BDBM50198751
PNG
(CHEMBL3927642)
Show SMILES CCC(=O)N1CCOc2c(C1)cc(cc2C(=O)N[C@H]1CCCN(C)C1)-c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C27H35N3O5/c1-5-25(31)30-9-10-35-26-20(16-30)11-18(19-12-22(33-3)15-23(13-19)34-4)14-24(26)27(32)28-21-7-6-8-29(2)17-21/h11-15,21H,5-10,16-17H2,1-4H3,(H,28,32)/t21-/m0/s1
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n/an/an/a 134n/an/an/an/an/a



Ludwig-Maximilians-Universit£t M£nchen

Curated by ChEMBL


Assay Description
Binding affinity to human CBP/P300 expressed in Escherichia coli BL21(DE3)-R3 by isothermal titration calorimetry


J Med Chem 59: 8889-8912 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00774
BindingDB Entry DOI: 10.7270/Q2736SVT
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
CREB-binding protein


(Homo sapiens (Human))
BDBM50151663
PNG
(CHEMBL3774655)
Show SMILES CCC(=O)N1CCOc2c(C1)cc(cc2OC[C@H]1CCCN(C)C1)-c1ccc(OC)c(OC)c1
Show InChI InChI=1S/C27H36N2O5/c1-5-26(30)29-11-12-33-27-22(17-29)13-21(20-8-9-23(31-3)24(14-20)32-4)15-25(27)34-18-19-7-6-10-28(2)16-19/h8-9,13-15,19H,5-7,10-12,16-18H2,1-4H3/t19-/m0/s1
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n/an/an/a 151n/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Binding affinity to CBP (unknown origin) by isothermal titration calorimetric analysis


J Med Chem 59: 1271-98 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01514
BindingDB Entry DOI: 10.7270/Q2X92D6H
More data for this
Ligand-Target Pair
CREB-binding protein/Histone acetyltransferase p300


(Homo sapiens (Human))
BDBM50151663
PNG
(CHEMBL3774655)
Show SMILES CCC(=O)N1CCOc2c(C1)cc(cc2OC[C@H]1CCCN(C)C1)-c1ccc(OC)c(OC)c1
Show InChI InChI=1S/C27H36N2O5/c1-5-26(30)29-11-12-33-27-22(17-29)13-21(20-8-9-23(31-3)24(14-20)32-4)15-25(27)34-18-19-7-6-10-28(2)16-19/h8-9,13-15,19H,5-7,10-12,16-18H2,1-4H3/t19-/m0/s1
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n/an/an/a 151n/an/an/an/an/a



Ludwig-Maximilians-Universit£t M£nchen

Curated by ChEMBL


Assay Description
Binding affinity to human CBP/P300 expressed in Escherichia coli BL21(DE3)-R3 by isothermal titration calorimetry


J Med Chem 59: 8889-8912 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00774
BindingDB Entry DOI: 10.7270/Q2736SVT
More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50151663
PNG
(CHEMBL3774655)
Show SMILES CCC(=O)N1CCOc2c(C1)cc(cc2OC[C@H]1CCCN(C)C1)-c1ccc(OC)c(OC)c1
Show InChI InChI=1S/C27H36N2O5/c1-5-26(30)29-11-12-33-27-22(17-29)13-21(20-8-9-23(31-3)24(14-20)32-4)15-25(27)34-18-19-7-6-10-28(2)16-19/h8-9,13-15,19H,5-7,10-12,16-18H2,1-4H3/t19-/m0/s1
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n/an/an/a 151n/an/an/an/an/a



University of Freiburg

Curated by ChEMBL


Assay Description
Inhibition of human CREBBP expressed in competent escherichia coli BL21(DE3)-R3-pRARE2 cells by isothermal titration calorimetry


J Med Chem 59: 1249-70 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01502
BindingDB Entry DOI: 10.7270/Q2DV1MRN
More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50148554
PNG
(CHEMBL3770598)
Show SMILES CCOc1ccc(cc1NC(=O)c1cc(cc(c1)-c1ccoc1)C(O)=O)C(C)=O
Show InChI InChI=1S/C22H19NO6/c1-3-29-20-5-4-14(13(2)24)11-19(20)23-21(25)17-8-16(15-6-7-28-12-15)9-18(10-17)22(26)27/h4-12H,3H2,1-2H3,(H,23,25)(H,26,27)
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n/an/an/a 170n/an/an/an/an/a



University of Z£rich

Curated by ChEMBL


Assay Description
Competitive binding affinity to human His-tagged CREBBP expressed in T7 phage-infected Escherichia coli BL21(DE3) cells incubated for 1 hr by bromosc...


J Med Chem 59: 1350-6 (2016)


Article DOI: 10.1021/acs.jmedchem.5b00172
BindingDB Entry DOI: 10.7270/Q2F47R0S
More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM188517
PNG
(PF-CBP1)
Show SMILES CCCOc1ccc(CCc2nc3cc(ccc3n2CCN2CCOCC2)-c2c(C)noc2C)cc1
Show InChI InChI=1S/C29H36N4O3/c1-4-17-35-25-9-5-23(6-10-25)7-12-28-30-26-20-24(29-21(2)31-36-22(29)3)8-11-27(26)33(28)14-13-32-15-18-34-19-16-32/h5-6,8-11,20H,4,7,12-19H2,1-3H3
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n/an/an/a 190n/an/an/an/an/a



Pfizer



Assay Description
Experiments were performed using recombinant CBP and BRD4 bromodomainsusing the procedure reported recently (Hett et al., 2015).


Chem Biol 22: 1588-96 (2015)


Article DOI: 10.1016/j.chembiol.2015.10.013
BindingDB Entry DOI: 10.7270/Q2V69HC0
More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50148554
PNG
(CHEMBL3770598)
Show SMILES CCOc1ccc(cc1NC(=O)c1cc(cc(c1)-c1ccoc1)C(O)=O)C(C)=O
Show InChI InChI=1S/C22H19NO6/c1-3-29-20-5-4-14(13(2)24)11-19(20)23-21(25)17-8-16(15-6-7-28-12-15)9-18(10-17)22(26)27/h4-12H,3H2,1-2H3,(H,23,25)(H,26,27)
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n/an/an/a 300n/an/an/an/an/a



University of Z£rich

Curated by ChEMBL


Assay Description
Binding affinity to human His-tagged CREBBP expressed in Escherichia coli BL21(DE3) cells by isothermal titration calorimetry


J Med Chem 59: 1350-6 (2016)


Article DOI: 10.1021/acs.jmedchem.5b00172
BindingDB Entry DOI: 10.7270/Q2F47R0S
More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50148556
PNG
(CHEMBL3770322)
Show SMILES CCOc1ccc(cc1NC(=O)c1cc(COC2CCCCO2)cc(c1)C(O)=O)C(C)=O
Show InChI InChI=1S/C24H27NO7/c1-3-30-21-8-7-17(15(2)26)13-20(21)25-23(27)18-10-16(11-19(12-18)24(28)29)14-32-22-6-4-5-9-31-22/h7-8,10-13,22H,3-6,9,14H2,1-2H3,(H,25,27)(H,28,29)
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n/an/an/a 370n/an/an/an/an/a



University of Z£rich

Curated by ChEMBL


Assay Description
Competitive binding affinity to human His-tagged CREBBP expressed in T7 phage-infected Escherichia coli BL21(DE3) cells incubated for 1 hr by bromosc...


J Med Chem 59: 1350-6 (2016)


Article DOI: 10.1021/acs.jmedchem.5b00172
BindingDB Entry DOI: 10.7270/Q2F47R0S
More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50151661
PNG
(CHEMBL3752296)
Show SMILES COc1ccc2CCCN(CCCNC(=O)c3cccc4NC(=O)[C@@H](C)Nc34)c2c1
Show InChI InChI=1S/C23H28N4O3/c1-15-22(28)26-19-8-3-7-18(21(19)25-15)23(29)24-11-5-13-27-12-4-6-16-9-10-17(30-2)14-20(16)27/h3,7-10,14-15,25H,4-6,11-13H2,1-2H3,(H,24,29)(H,26,28)/t15-/m1/s1
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Genentech

Curated by ChEMBL


Assay Description
Binding affinity to CBP (unknown origin) by isothermal titration calorimetric analysis


J Med Chem 59: 1271-98 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01514
BindingDB Entry DOI: 10.7270/Q2X92D6H
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
CREB-binding protein


(Homo sapiens (Human))
BDBM50151661
PNG
(CHEMBL3752296)
Show SMILES COc1ccc2CCCN(CCCNC(=O)c3cccc4NC(=O)[C@@H](C)Nc34)c2c1
Show InChI InChI=1S/C23H28N4O3/c1-15-22(28)26-19-8-3-7-18(21(19)25-15)23(29)24-11-5-13-27-12-4-6-16-9-10-17(30-2)14-20(16)27/h3,7-10,14-15,25H,4-6,11-13H2,1-2H3,(H,24,29)(H,26,28)/t15-/m1/s1
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n/an/an/a 390n/an/an/an/an/a



University of Freiburg

Curated by ChEMBL


Assay Description
Inhibition of human His6-tagged CREBBP expressed in competent Escherichia coli BL21 (DE3) cells by isothermal titration calorimetry


J Med Chem 59: 1249-70 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01502
BindingDB Entry DOI: 10.7270/Q2DV1MRN
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
CREB-binding protein


(Homo sapiens (Human))
BDBM50148553
PNG
(CHEMBL3769500)
Show SMILES CCOc1ccc(cc1NC(=O)c1cccc(c1)C(=O)OC)C(C)=O
Show InChI InChI=1S/C19H19NO5/c1-4-25-17-9-8-13(12(2)21)11-16(17)20-18(22)14-6-5-7-15(10-14)19(23)24-3/h5-11H,4H2,1-3H3,(H,20,22)
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University of Z£rich

Curated by ChEMBL


Assay Description
Competitive binding affinity to human His-tagged CREBBP expressed in T7 phage-infected Escherichia coli BL21(DE3) cells incubated for 1 hr by bromosc...


J Med Chem 59: 1350-6 (2016)


Article DOI: 10.1021/acs.jmedchem.5b00172
BindingDB Entry DOI: 10.7270/Q2F47R0S
More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50148555
PNG
(CHEMBL3771341)
Show SMILES CCOc1ccc(cc1NC(=O)c1cc(COC)cc(c1)C(O)=O)C(C)=O
Show InChI InChI=1S/C20H21NO6/c1-4-27-18-6-5-14(12(2)22)10-17(18)21-19(23)15-7-13(11-26-3)8-16(9-15)20(24)25/h5-10H,4,11H2,1-3H3,(H,21,23)(H,24,25)
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n/an/an/a 530n/an/an/an/an/a



University of Z£rich

Curated by ChEMBL


Assay Description
Competitive binding affinity to human His-tagged CREBBP expressed in T7 phage-infected Escherichia coli BL21(DE3) cells incubated for 1 hr by bromosc...


J Med Chem 59: 1350-6 (2016)


Article DOI: 10.1021/acs.jmedchem.5b00172
BindingDB Entry DOI: 10.7270/Q2F47R0S
More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50092310
PNG
(CHEMBL3581661 | US9675697, Cpd. No. 23)
Show SMILES COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ccnc(-c3c(C)[nH]nc3C3CC3)c21
Show InChI InChI=1S/C24H23N5O2/c1-11-21(23(28-27-11)14-5-6-14)24-22-15-10-19(30-4)16(20-12(2)29-31-13(20)3)9-18(15)26-17(22)7-8-25-24/h7-10,14,26H,5-6H2,1-4H3,(H,27,28)
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n/an/an/a 670n/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to biotinylated CREBBP (1043 to 1159 amino acid residues) (unknown origin) expressed in Rosetta2 DE3 cells by bio-layer interferomet...


J Med Chem 58: 4927-39 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00613
BindingDB Entry DOI: 10.7270/Q2XD13FK
More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50148552
PNG
(CHEMBL3770150)
Show SMILES CCOc1ccc(cc1NC(=O)c1cccc(c1)C(O)=O)C(C)=O
Show InChI InChI=1S/C18H17NO5/c1-3-24-16-8-7-12(11(2)20)10-15(16)19-17(21)13-5-4-6-14(9-13)18(22)23/h4-10H,3H2,1-2H3,(H,19,21)(H,22,23)
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n/an/an/a 670n/an/an/an/an/a



University of Z£rich

Curated by ChEMBL


Assay Description
Competitive binding affinity to human His-tagged CREBBP expressed in T7 phage-infected Escherichia coli BL21(DE3) cells incubated for 1 hr by bromosc...


J Med Chem 59: 1350-6 (2016)


Article DOI: 10.1021/acs.jmedchem.5b00172
BindingDB Entry DOI: 10.7270/Q2F47R0S
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
CREB-binding protein


(Homo sapiens (Human))
BDBM50148552
PNG
(CHEMBL3770150)
Show SMILES CCOc1ccc(cc1NC(=O)c1cccc(c1)C(O)=O)C(C)=O
Show InChI InChI=1S/C18H17NO5/c1-3-24-16-8-7-12(11(2)20)10-15(16)19-17(21)13-5-4-6-14(9-13)18(22)23/h4-10H,3H2,1-2H3,(H,19,21)(H,22,23)
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n/an/an/a 770n/an/an/an/an/a



University of Z£rich

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal His-tagged KDM4A (1 to 359 residues) expressed in Escherichia coli using biotin-H3K9me3 as substrate preincubated for ...


J Med Chem 59: 1340-9 (2016)


Article DOI: 10.1021/acs.jmedchem.5b00171
BindingDB Entry DOI: 10.7270/Q22J6DRV
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
CREB-binding protein


(Homo sapiens (Human))
BDBM50148555
PNG
(CHEMBL3771341)
Show SMILES CCOc1ccc(cc1NC(=O)c1cc(COC)cc(c1)C(O)=O)C(C)=O
Show InChI InChI=1S/C20H21NO6/c1-4-27-18-6-5-14(12(2)22)10-17(18)21-19(23)15-7-13(11-26-3)8-16(9-15)20(24)25/h5-10H,4,11H2,1-3H3,(H,21,23)(H,24,25)
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n/an/an/a 800n/an/an/an/an/a



University of Z£rich

Curated by ChEMBL


Assay Description
Binding affinity to human His-tagged CREBBP expressed in Escherichia coli BL21(DE3) cells by isothermal titration calorimetry


J Med Chem 59: 1350-6 (2016)


Article DOI: 10.1021/acs.jmedchem.5b00172
BindingDB Entry DOI: 10.7270/Q2F47R0S
More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50207718
PNG
(CHEMBL3959972)
Show SMILES CCC(=O)N1CCc2[nH]nc(c2C1)-c1ccccc1
Show InChI InChI=1S/C15H17N3O/c1-2-14(19)18-9-8-13-12(10-18)15(17-16-13)11-6-4-3-5-7-11/h3-7H,2,8-10H2,1H3,(H,16,17)
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n/an/an/a 1.53E+3n/an/an/an/an/a



University of Dundee

Curated by ChEMBL


Assay Description
Binding affinity to human His10-tagged CREBBP expressed in Escherichia coli BL21(DE3)-R3 using methanol by SPR assay


ACS Med Chem Lett 7: 1213-1218 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00154
BindingDB Entry DOI: 10.7270/Q2VM4F7M
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
CREB-binding protein


(Homo sapiens (Human))
BDBM50148552
PNG
(CHEMBL3770150)
Show SMILES CCOc1ccc(cc1NC(=O)c1cccc(c1)C(O)=O)C(C)=O
Show InChI InChI=1S/C18H17NO5/c1-3-24-16-8-7-12(11(2)20)10-15(16)19-17(21)13-5-4-6-14(9-13)18(22)23/h4-10H,3H2,1-2H3,(H,19,21)(H,22,23)
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n/an/an/a 2.00E+3n/an/an/an/an/a



University of Z£rich

Curated by ChEMBL


Assay Description
Binding affinity to human His-tagged CREBBP expressed in Escherichia coli BL21(DE3) cells by isothermal titration calorimetry


J Med Chem 59: 1350-6 (2016)


Article DOI: 10.1021/acs.jmedchem.5b00172
BindingDB Entry DOI: 10.7270/Q2F47R0S
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
CREB-binding protein


(Homo sapiens (Human))
BDBM50148557
PNG
(CHEMBL3770877)
Show SMILES CCOc1ccc(cc1C(=O)Nc1cccc(c1)C(O)=O)C(C)=O
Show InChI InChI=1S/C18H17NO5/c1-3-24-16-8-7-12(11(2)20)10-15(16)17(21)19-14-6-4-5-13(9-14)18(22)23/h4-10H,3H2,1-2H3,(H,19,21)(H,22,23)
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n/an/an/a 2.50E+3n/an/an/an/an/a



University of Z£rich

Curated by ChEMBL


Assay Description
Competitive binding affinity to human His-tagged CREBBP expressed in T7 phage-infected Escherichia coli BL21(DE3) cells incubated for 1 hr by bromosc...


J Med Chem 59: 1350-6 (2016)


Article DOI: 10.1021/acs.jmedchem.5b00172
BindingDB Entry DOI: 10.7270/Q2F47R0S
More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50380682
PNG
(CHEMBL2017291 | I-BET151 (16))
Show SMILES COc1cc2c3n([C@H](C)c4ccccn4)c(=O)[nH]c3cnc2cc1-c1c(C)noc1C
Show InChI InChI=1S/C23H21N5O3/c1-12-21(14(3)31-27-12)16-9-18-15(10-20(16)30-4)22-19(11-25-18)26-23(29)28(22)13(2)17-7-5-6-8-24-17/h5-11,13H,1-4H3,(H,26,29)/t13-/m1/s1
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n/an/an/a 3.08E+3n/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to biotinylated CREBBP (1043 to 1159 amino acid residues) (unknown origin) expressed in Rosetta2 DE3 cells by bio-layer interferomet...


J Med Chem 58: 4927-39 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00613
BindingDB Entry DOI: 10.7270/Q2XD13FK
More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50207718
PNG
(CHEMBL3959972)
Show SMILES CCC(=O)N1CCc2[nH]nc(c2C1)-c1ccccc1
Show InChI InChI=1S/C15H17N3O/c1-2-14(19)18-9-8-13-12(10-18)15(17-16-13)11-6-4-3-5-7-11/h3-7H,2,8-10H2,1H3,(H,16,17)
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n/an/an/a 3.65E+3n/an/an/an/an/a



University of Dundee

Curated by ChEMBL


Assay Description
Binding affinity to human His10-tagged CREBBP expressed in Escherichia coli BL21(DE3)-R3 using 0.5% DMSO by SPR assay


ACS Med Chem Lett 7: 1213-1218 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00154
BindingDB Entry DOI: 10.7270/Q2VM4F7M
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
CREB-binding protein


(Homo sapiens (Human))
BDBM50150909
PNG
(CHEMBL3774461)
Show SMILES CC(=O)c1c(C)[nH]c(C(=O)Nc2cccc(c2)C(O)=O)c1C
Show InChI InChI=1S/C16H16N2O4/c1-8-13(10(3)19)9(2)17-14(8)15(20)18-12-6-4-5-11(7-12)16(21)22/h4-7,17H,1-3H3,(H,18,20)(H,21,22)
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n/an/an/a 4.20E+3n/an/an/an/an/a



University of Z£rich

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal His-tagged KDM4A (1 to 359 residues) expressed in Escherichia coli using biotin-H3K9me3 as substrate preincubated for ...


J Med Chem 59: 1340-9 (2016)


Article DOI: 10.1021/acs.jmedchem.5b00171
BindingDB Entry DOI: 10.7270/Q22J6DRV
More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50297510
PNG
(CHEMBL540163 | N-allyl-N-(2-((2-amino-2-oxoethyl)(...)
Show SMILES CC(C)CN(CC(N)=O)C(=O)CN(CC=C)C(=O)CN(Cc1ccco1)C(=O)CN(Cc1ccco1)C(=O)CN(Cc1ccco1)C(=O)CN(CC(C)C)C(=O)CNCC#C
Show InChI InChI=1S/C43H58N8O10/c1-7-15-45-20-38(53)48(22-33(5)6)29-41(56)50(24-35-13-10-18-60-35)31-43(58)51(25-36-14-11-19-61-36)30-42(57)49(23-34-12-9-17-59-34)28-39(54)46(16-8-2)27-40(55)47(21-32(3)4)26-37(44)52/h1,8-14,17-19,32-33,45H,2,15-16,20-31H2,3-6H3,(H2,44,52)
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n/an/an/a 4.60E+3n/an/an/an/an/a



University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Binding affinity to histidine tagged KIX domain of CREB-binding protein by fluorescence polarization assay


Bioorg Med Chem Lett 19: 3866-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.153
BindingDB Entry DOI: 10.7270/Q25Q4W5X
More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50148551
PNG
(CHEMBL3769993)
Show SMILES CCOc1ccc(cc1NC(=O)\C=C\C(O)=O)C(C)=O
Show InChI InChI=1S/C14H15NO5/c1-3-20-12-5-4-10(9(2)16)8-11(12)15-13(17)6-7-14(18)19/h4-8H,3H2,1-2H3,(H,15,17)(H,18,19)/b7-6+
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n/an/an/a 4.70E+3n/an/an/an/an/a



University of Z£rich

Curated by ChEMBL


Assay Description
Competitive binding affinity to human His-tagged CREBBP expressed in T7 phage-infected Escherichia coli BL21(DE3) cells incubated for 1 hr by bromosc...


J Med Chem 59: 1350-6 (2016)


Article DOI: 10.1021/acs.jmedchem.5b00172
BindingDB Entry DOI: 10.7270/Q2F47R0S
More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50172112
PNG
(CHEMBL3809834)
Show SMILES CC(=O)n1cc(-c2c(C)nn3CCOc23)c2ccccc12
Show InChI InChI=1S/C16H15N3O2/c1-10-15(16-19(17-10)7-8-21-16)13-9-18(11(2)20)14-6-4-3-5-12(13)14/h3-6,9H,7-8H2,1-2H3
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n/an/an/a 6.20E+3n/an/an/an/an/a



University of Z£rich

Curated by ChEMBL


Assay Description
Competitive binding affinity to CBP (unknown origin) measured after 1 hr by BROMOscan assay


J Med Chem 59: 3087-97 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01757
BindingDB Entry DOI: 10.7270/Q2MP556R
More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50028142
PNG
(CHEMBL2177300)
Show SMILES C[C@H]1C[C@@H](Nc2ccc(Cl)cc2)c2cc(ccc2N1C(C)=O)-c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C25H23ClN2O3/c1-15-13-23(27-21-10-8-20(26)9-11-21)22-14-19(7-12-24(22)28(15)16(2)29)17-3-5-18(6-4-17)25(30)31/h3-12,14-15,23,27H,13H2,1-2H3,(H,30,31)/t15-,23+/m0/s1
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n/an/an/a 6.30E+3n/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Binding affinity to CREBBP (unknown origin) by ITC method


J Med Chem 57: 8111-31 (2014)


Article DOI: 10.1021/jm5010539
BindingDB Entry DOI: 10.7270/Q23R0VGR
More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50172108
PNG
(CHEMBL3809158)
Show SMILES CC(=O)n1cc(-c2c(C)n(n(c2=O)S(C)(=O)=O)S(C)(=O)=O)c2ccccc12
Show InChI InChI=1S/C16H17N3O6S2/c1-10-15(16(21)19(27(4,24)25)18(10)26(3,22)23)13-9-17(11(2)20)14-8-6-5-7-12(13)14/h5-9H,1-4H3
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n/an/an/a 6.60E+3n/an/an/an/an/a



University of Z£rich

Curated by ChEMBL


Assay Description
Competitive binding affinity to CBP (unknown origin) measured after 1 hr by BROMOscan assay


J Med Chem 59: 3087-97 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01757
BindingDB Entry DOI: 10.7270/Q2MP556R
More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50207718
PNG
(CHEMBL3959972)
Show SMILES CCC(=O)N1CCc2[nH]nc(c2C1)-c1ccccc1
Show InChI InChI=1S/C15H17N3O/c1-2-14(19)18-9-8-13-12(10-18)15(17-16-13)11-6-4-3-5-7-11/h3-7H,2,8-10H2,1H3,(H,16,17)
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n/an/an/a 7.08E+3n/an/an/an/an/a



University of Dundee

Curated by ChEMBL


Assay Description
Binding affinity to human His10-tagged CREBBP expressed in Escherichia coli BL21(DE3)-R3 using 1% DMSO by SPR assay


ACS Med Chem Lett 7: 1213-1218 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00154
BindingDB Entry DOI: 10.7270/Q2VM4F7M
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
CREB-binding protein


(Homo sapiens (Human))
BDBM50297509
PNG
(CHEMBL557205 | N-allyl-N-(2-((2-amino-2-oxoethyl)(...)
Show SMILES CC(C)CN(CC(N)=O)C(=O)CN(CC=C)C(=O)CN(Cc1ccco1)C(=O)CN(Cc1ccco1)C(=O)CN(Cc1ccco1)C(=O)CN(CC(C)C)C(=O)CNCc1cn(CCCCN(CC(N)=O)C(=O)CN(Cc2ccc3OCOc3c2)C(=O)CN(CCCCN)C(=O)CN(Cc2ccc3OCOc3c2)C(=O)CN(CC(C)C)C(=O)CN(CCCCN)C(=O)CNCc2ccc3OCOc3c2)nn1
Show InChI InChI=1S/C97H133N21O23/c1-8-29-106(55-91(126)110(44-68(2)3)54-85(101)120)88(123)60-115(50-75-18-15-34-133-75)96(131)63-117(52-77-20-17-36-135-77)97(132)64-116(51-76-19-16-35-134-76)95(130)61-111(45-69(4)5)87(122)43-103-41-74-49-118(105-104-74)33-14-13-32-107(53-84(100)119)89(124)58-113(47-72-22-25-79-82(38-72)140-66-137-79)93(128)57-109(31-12-10-28-99)90(125)59-114(48-73-23-26-80-83(39-73)141-67-138-80)94(129)62-112(46-70(6)7)92(127)56-108(30-11-9-27-98)86(121)42-102-40-71-21-24-78-81(37-71)139-65-136-78/h8,15-26,34-39,49,68-70,102-103H,1,9-14,27-33,40-48,50-67,98-99H2,2-7H3,(H2,100,119)(H2,101,120)
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n/an/an/a 8.30E+3n/an/an/an/an/a



University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Binding affinity to histidine tagged KIX domain of CREB-binding protein by fluorescence polarization assay


Bioorg Med Chem Lett 19: 3866-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.153
BindingDB Entry DOI: 10.7270/Q25Q4W5X
More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50172110
PNG
(CHEMBL3809876)
Show SMILES COc1ccc(cc1)C(=O)n1[nH]c(=O)c(c1C)-c1cn(C(C)=O)c2ccccc12
Show InChI InChI=1S/C22H19N3O4/c1-13-20(18-12-24(14(2)26)19-7-5-4-6-17(18)19)21(27)23-25(13)22(28)15-8-10-16(29-3)11-9-15/h4-12H,1-3H3,(H,23,27)
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n/an/an/a 9.30E+3n/an/an/an/an/a



University of Z£rich

Curated by ChEMBL


Assay Description
Competitive binding affinity to CBP (unknown origin) measured after 1 hr by BROMOscan assay


J Med Chem 59: 3087-97 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01757
BindingDB Entry DOI: 10.7270/Q2MP556R
More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50172113
PNG
(CHEMBL3809636)
Show SMILES CCCOc1ccc2n(cc(-c3c(C)n([nH]c3=O)C(=O)c3ccc(OC)cc3)c2c1)C(C)=O
Show InChI InChI=1S/C25H25N3O5/c1-5-12-33-19-10-11-22-20(13-19)21(14-27(22)16(3)29)23-15(2)28(26-24(23)30)25(31)17-6-8-18(32-4)9-7-17/h6-11,13-14H,5,12H2,1-4H3,(H,26,30)
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n/an/an/a 9.80E+3n/an/an/an/an/a



University of Z£rich

Curated by ChEMBL


Assay Description
Competitive binding affinity to CBP (unknown origin) measured after 1 hr by BROMOscan assay


J Med Chem 59: 3087-97 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01757
BindingDB Entry DOI: 10.7270/Q2MP556R
More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50365463
PNG
(CHEMBL1232461)
Show SMILES CCNC(=O)C[C@@H]1N=C(c2ccc(Cl)cc2)c2cc(OC)ccc2-n2c(C)nnc12
Show InChI InChI=1S/C22H22ClN5O2/c1-4-24-20(29)12-18-22-27-26-13(2)28(22)19-10-9-16(30-3)11-17(19)21(25-18)14-5-7-15(23)8-6-14/h5-11,18H,4,12H2,1-3H3,(H,24,29)/t18-/m0/s1
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n/an/an/a>1.00E+4n/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to biotinylated CREBBP (1043 to 1159 amino acid residues) (unknown origin) expressed in Rosetta2 DE3 cells by bio-layer interferomet...


J Med Chem 58: 4927-39 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00613
BindingDB Entry DOI: 10.7270/Q2XD13FK
More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50172111
PNG
(CHEMBL3808729)
Show SMILES CC(=O)n1cc(-c2c(C)n([nH]c2=O)C(=O)N2CCOCC2)c2ccccc12
Show InChI InChI=1S/C19H20N4O4/c1-12-17(15-11-22(13(2)24)16-6-4-3-5-14(15)16)18(25)20-23(12)19(26)21-7-9-27-10-8-21/h3-6,11H,7-10H2,1-2H3,(H,20,25)
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n/an/an/a 1.20E+4n/an/an/an/an/a



University of Z£rich

Curated by ChEMBL


Assay Description
Competitive binding affinity to CBP (unknown origin) measured after 1 hr by BROMOscan assay


J Med Chem 59: 3087-97 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01757
BindingDB Entry DOI: 10.7270/Q2MP556R
More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50150938
PNG
(CHEMBL3775724)
Show SMILES CC(=O)c1c(C)[nH]c(C(=O)Nc2cc(ccc2C)-c2nnco2)c1C
Show InChI InChI=1S/C18H18N4O3/c1-9-5-6-13(18-22-19-8-25-18)7-14(9)21-17(24)16-10(2)15(12(4)23)11(3)20-16/h5-8,20H,1-4H3,(H,21,24)
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n/an/an/a 1.30E+4n/an/an/an/an/a



University of Z£rich

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal His-tagged KDM4A (1 to 359 residues) expressed in Escherichia coli using biotin-H3K9me3 as substrate preincubated for ...


J Med Chem 59: 1340-9 (2016)


Article DOI: 10.1021/acs.jmedchem.5b00171
BindingDB Entry DOI: 10.7270/Q22J6DRV
More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50172109
PNG
(CHEMBL3809575)
Show SMILES CC(=O)n1cc(-c2c(C)n(C(=O)CCc3ccccc3)n(C(=O)CCc3ccccc3)c2=O)c2ccccc12
Show InChI InChI=1S/C32H29N3O4/c1-22-31(27-21-33(23(2)36)28-16-10-9-15-26(27)28)32(39)35(30(38)20-18-25-13-7-4-8-14-25)34(22)29(37)19-17-24-11-5-3-6-12-24/h3-16,21H,17-20H2,1-2H3
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n/an/an/a 1.70E+4n/an/an/an/an/a



University of Z£rich

Curated by ChEMBL


Assay Description
Competitive binding affinity to CBP (unknown origin) measured after 1 hr by BROMOscan assay


J Med Chem 59: 3087-97 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01757
BindingDB Entry DOI: 10.7270/Q2MP556R
More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50158692
PNG
(CHEMBL1236441)
Show SMILES CC(=O)n1c2c(CCCC2=O)c2ccccc12
Show InChI InChI=1S/C14H13NO2/c1-9(16)15-12-7-3-2-5-10(12)11-6-4-8-13(17)14(11)15/h2-3,5,7H,4,6,8H2,1H3
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n/an/an/a 1.96E+4n/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Binding affinity to CBP bromodomain (unknown origin) by fluorescence spectroscopic analysis


J Med Chem 59: 1271-98 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01514
BindingDB Entry DOI: 10.7270/Q2X92D6H
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
CREB-binding protein


(Homo sapiens (Human))
BDBM50158615
PNG
(ISCHEMIN | Ischemin)
Show SMILES Cc1cc(\N=N\c2cc(c(C)cc2C)S(O)(=O)=O)c(N)cc1O
Show InChI InChI=1S/C15H17N3O4S/c1-8-4-10(3)15(23(20,21)22)7-12(8)17-18-13-5-9(2)14(19)6-11(13)16/h4-7,19H,16H2,1-3H3,(H,20,21,22)/b18-17+
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n/an/an/a 1.96E+4n/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Binding affinity to CBP bromodomain (unknown origin) by fluorescence spectroscopic analysis


J Med Chem 59: 1271-98 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01514
BindingDB Entry DOI: 10.7270/Q2X92D6H
More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50172107
PNG
(CHEMBL3810303)
Show SMILES CC(=O)n1cc(-c2c(C)[nH][nH]c2=O)c2ccccc12
Show InChI InChI=1S/C14H13N3O2/c1-8-13(14(19)16-15-8)11-7-17(9(2)18)12-6-4-3-5-10(11)12/h3-7H,1-2H3,(H2,15,16,19)
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n/an/an/a 2.00E+4n/an/an/an/an/a



University of Z£rich

Curated by ChEMBL


Assay Description
Competitive binding affinity to CBP (unknown origin) measured after 1 hr by BROMOscan assay


J Med Chem 59: 3087-97 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01757
BindingDB Entry DOI: 10.7270/Q2MP556R
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
CREB-binding protein


(Homo sapiens (Human))
BDBM50172107
PNG
(CHEMBL3810303)
Show SMILES CC(=O)n1cc(-c2c(C)[nH][nH]c2=O)c2ccccc12
Show InChI InChI=1S/C14H13N3O2/c1-8-13(14(19)16-15-8)11-7-17(9(2)18)12-6-4-3-5-10(11)12/h3-7H,1-2H3,(H2,15,16,19)
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n/an/an/a 2.00E+4n/an/an/an/an/a



University of Z£rich

Curated by ChEMBL


Assay Description
Competitive binding affinity to human His-tagged CREBBP (1081 to 1097 residues) expressed in T7 phage-infected Escherichia coli BL21(DE3) cells measu...


J Med Chem 59: 3087-97 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01757
BindingDB Entry DOI: 10.7270/Q2MP556R
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
CREB-binding protein


(Homo sapiens (Human))
BDBM50207718
PNG
(CHEMBL3959972)
Show SMILES CCC(=O)N1CCc2[nH]nc(c2C1)-c1ccccc1
Show InChI InChI=1S/C15H17N3O/c1-2-14(19)18-9-8-13-12(10-18)15(17-16-13)11-6-4-3-5-7-11/h3-7H,2,8-10H2,1H3,(H,16,17)
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n/an/an/a 2.67E+4n/an/an/an/an/a



University of Dundee

Curated by ChEMBL


Assay Description
Binding affinity to human His10-tagged CREBBP expressed in Escherichia coli BL21(DE3)-R3 using 3% DMSO by SPR assay


ACS Med Chem Lett 7: 1213-1218 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00154
BindingDB Entry DOI: 10.7270/Q2VM4F7M
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
CREB-binding protein


(Homo sapiens (Human))
BDBM50148550
PNG
(CHEMBL3770132)
Show SMILES CC(=O)c1cccc(NC(=O)c2c(C)c(C)sc2-n2cnnn2)c1
Show InChI InChI=1S/C16H15N5O2S/c1-9-11(3)24-16(21-8-17-19-20-21)14(9)15(23)18-13-6-4-5-12(7-13)10(2)22/h4-8H,1-3H3,(H,18,23)
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n/an/an/a 2.90E+4n/an/an/an/an/a



University of Z£rich

Curated by ChEMBL


Assay Description
Competitive binding affinity to human His-tagged CREBBP expressed in T7 phage-infected Escherichia coli BL21(DE3) cells incubated for 1 hr by bromosc...


J Med Chem 59: 1350-6 (2016)


Article DOI: 10.1021/acs.jmedchem.5b00172
BindingDB Entry DOI: 10.7270/Q2F47R0S
More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50148550
PNG
(CHEMBL3770132)
Show SMILES CC(=O)c1cccc(NC(=O)c2c(C)c(C)sc2-n2cnnn2)c1
Show InChI InChI=1S/C16H15N5O2S/c1-9-11(3)24-16(21-8-17-19-20-21)14(9)15(23)18-13-6-4-5-12(7-13)10(2)22/h4-8H,1-3H3,(H,18,23)
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n/an/an/a 2.90E+4n/an/an/an/an/a



University of Z£rich

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal His-tagged KDM4A (1 to 359 residues) expressed in Escherichia coli using biotin-H3K9me3 as substrate preincubated for ...


J Med Chem 59: 1340-9 (2016)


Article DOI: 10.1021/acs.jmedchem.5b00171
BindingDB Entry DOI: 10.7270/Q22J6DRV
More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50148558
PNG
(CHEMBL3771369)
Show SMILES CCOc1ccc(cc1NC(=O)c1cccc(c1)C(O)=O)C(=O)NC
Show InChI InChI=1S/C18H18N2O5/c1-3-25-15-8-7-12(16(21)19-2)10-14(15)20-17(22)11-5-4-6-13(9-11)18(23)24/h4-10H,3H2,1-2H3,(H,19,21)(H,20,22)(H,23,24)
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n/an/an/a 3.70E+4n/an/an/an/an/a



University of Z£rich

Curated by ChEMBL


Assay Description
Competitive binding affinity to human His-tagged CREBBP expressed in T7 phage-infected Escherichia coli BL21(DE3) cells incubated for 1 hr by bromosc...


J Med Chem 59: 1350-6 (2016)


Article DOI: 10.1021/acs.jmedchem.5b00172
BindingDB Entry DOI: 10.7270/Q2F47R0S
More data for this
Ligand-Target Pair
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