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Compile Data Set for Download or QSAR

Found 106 hits Enz. Inhib. hit(s) with Target = 'Cell division protein FtsZ'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cell division protein ftsZ


(Bacillus subtilis)
BDBM50079357
PNG
(CHEMBL3416826)
Show SMILES FC(F)(F)c1cccc(c1)-c1ccc(\C=C2\SC(=S)NC2=O)o1
Show InChI InChI=1S/C15H8F3NO2S2/c16-15(17,18)9-3-1-2-8(6-9)11-5-4-10(21-11)7-12-13(20)19-14(22)23-12/h1-7H,(H,19,20,22)/b12-7+
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n/an/an/a 1.50E+3n/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Binding affinity to Bacillus subtilis FtsZ


Eur J Med Chem 95: 1-15 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.026
BindingDB Entry DOI: 10.7270/Q2S75J14
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Staphylococcus aureus)
BDBM50402381
PNG
(CHEMBL2207296)
Show SMILES COc1cc2cc(-c3cccc(c3)-c3ccc(cc3)-c3ccccc3)[n+](C)c(C)c2cc1OC
Show InChI InChI=1S/C31H28NO2/c1-21-28-20-31(34-4)30(33-3)19-27(28)18-29(32(21)2)26-12-8-11-25(17-26)24-15-13-23(14-16-24)22-9-6-5-7-10-22/h5-20H,1-4H3/q+1
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n/an/an/a 2.00E+3n/an/an/an/an/a



The State University of New Jersey

Curated by ChEMBL


Assay Description
Binding affinity to Staphylococcus aureus FtsZ expressed in Escherichia coli cells assessed as dissociation constant by fluorescence spectroscopy


Bioorg Med Chem 20: 7012-29 (2012)


Article DOI: 10.1016/j.bmc.2012.10.009
BindingDB Entry DOI: 10.7270/Q23779VJ
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Staphylococcus aureus)
BDBM50399003
PNG
(CHEMBL2180486)
Show SMILES CC(C)(C)c1ccc(cc1)-c1cccc(CN=C(N)N)c1
Show InChI InChI=1S/C18H23N3/c1-18(2,3)16-9-7-14(8-10-16)15-6-4-5-13(11-15)12-21-17(19)20/h4-11H,12H2,1-3H3,(H4,19,20,21)
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n/an/an/a 3.50E+3n/an/an/an/an/a



University of Medicine and Dentistry of New Jersey

Curated by ChEMBL


Assay Description
Binding affinity to Staphylococcus aureus FtsZ expressed in Escherichia coli BL21 (DE3) at 25 degC by fluorescence anisotropy assay


J Med Chem 55: 10160-76 (2012)


Article DOI: 10.1021/jm3012728
BindingDB Entry DOI: 10.7270/Q2ZG6TC8
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50399003
PNG
(CHEMBL2180486)
Show SMILES CC(C)(C)c1ccc(cc1)-c1cccc(CN=C(N)N)c1
Show InChI InChI=1S/C18H23N3/c1-18(2,3)16-9-7-14(8-10-16)15-6-4-5-13(11-15)12-21-17(19)20/h4-11H,12H2,1-3H3,(H4,19,20,21)
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n/an/an/a 3.80E+3n/an/an/an/an/a



University of Medicine and Dentistry of New Jersey

Curated by ChEMBL


Assay Description
Binding affinity to Escherichia coli FtsZ at 25 degC by fluorescence anisotropy assay


J Med Chem 55: 10160-76 (2012)


Article DOI: 10.1021/jm3012728
BindingDB Entry DOI: 10.7270/Q2ZG6TC8
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Staphylococcus aureus)
BDBM50402380
PNG
(CHEMBL2207300)
Show SMILES COc1cc2cc(-c3cccc(c3)-c3ccc(cc3)C(C)(C)C)[n+](C)c(C)c2cc1OC
Show InChI InChI=1S/C29H32NO2/c1-19-25-18-28(32-7)27(31-6)17-23(25)16-26(30(19)5)22-10-8-9-21(15-22)20-11-13-24(14-12-20)29(2,3)4/h8-18H,1-7H3/q+1
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n/an/an/a 5.40E+3n/an/an/an/an/a



The State University of New Jersey

Curated by ChEMBL


Assay Description
Binding affinity to Staphylococcus aureus FtsZ expressed in Escherichia coli cells assessed as dissociation constant by fluorescence spectroscopy


Bioorg Med Chem 20: 7012-29 (2012)


Article DOI: 10.1016/j.bmc.2012.10.009
BindingDB Entry DOI: 10.7270/Q23779VJ
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Mycobacterium tuberculosis)
BDBM50392993
PNG
(TOTAROL)
Show SMILES CC(C)c1c(O)ccc2c1CC[C@H]1C(C)(C)CCC[C@]21C
Show InChI InChI=1S/C20H30O/c1-13(2)18-14-7-10-17-19(3,4)11-6-12-20(17,5)15(14)8-9-16(18)21/h8-9,13,17,21H,6-7,10-12H2,1-5H3/t17-,20+/m0/s1
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n/an/an/a 1.10E+4n/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Binding affinity to Mycobacterium tuberculosis FtsZ


Eur J Med Chem 95: 1-15 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.026
BindingDB Entry DOI: 10.7270/Q2S75J14
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50010058
PNG
(CHEBI:51231 | DAPI)
Show SMILES NC(=N)c1ccc(cc1)-c1cc2ccc(cc2[nH]1)C(N)=N
Show InChI InChI=1S/C16H15N5/c17-15(18)10-3-1-9(2-4-10)13-7-11-5-6-12(16(19)20)8-14(11)21-13/h1-8,21H,(H3,17,18)(H3,19,20)
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n/an/an/a 1.66E+4n/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Binding affinity to Escherichia coli FtsZ by fluorescence anisotrophy


Eur J Med Chem 95: 1-15 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.026
BindingDB Entry DOI: 10.7270/Q2S75J14
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Staphylococcus aureus)
BDBM50439496
PNG
(CHEMBL2418096 | US9169182, J23)
Show SMILES COc1cc(C\C=C(\Cl)Cc2cc(O)cc(O)c2)c(OC)cc1Cl
Show InChI InChI=1S/C18H18Cl2O4/c1-23-17-10-16(20)18(24-2)8-12(17)3-4-13(19)5-11-6-14(21)9-15(22)7-11/h4,6-10,21-22H,3,5H2,1-2H3/b13-4+
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n/an/a 4.40E+4n/an/an/an/an/an/a



THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

US Patent


Assay Description
The bacterial cytoskeletal protein FtsZ is a GTPase and has structural homology to the eukaryotic cytoskeletal protein tubulin, but lacks significant...


US Patent US9169182 (2015)


BindingDB Entry DOI: 10.7270/Q22Z149Z
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Staphylococcus aureus)
BDBM186046
PNG
(US9169182, J24)
Show SMILES Oc1cc(O)cc(C\C(Cl)=C/Cc2cc(O)c(Cl)cc2O)c1
Show InChI InChI=1S/C16H14Cl2O4/c17-11(3-9-4-12(19)7-13(20)5-9)2-1-10-6-16(22)14(18)8-15(10)21/h2,4-8,19-22H,1,3H2/b11-2+
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n/an/a 8.80E+4n/an/an/an/an/an/a



THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

US Patent


Assay Description
The bacterial cytoskeletal protein FtsZ is a GTPase and has structural homology to the eukaryotic cytoskeletal protein tubulin, but lacks significant...


US Patent US9169182 (2015)


BindingDB Entry DOI: 10.7270/Q22Z149Z
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50439496
PNG
(CHEMBL2418096 | US9169182, J23)
Show SMILES COc1cc(C\C=C(\Cl)Cc2cc(O)cc(O)c2)c(OC)cc1Cl
Show InChI InChI=1S/C18H18Cl2O4/c1-23-17-10-16(20)18(24-2)8-12(17)3-4-13(19)5-11-6-14(21)9-15(22)7-11/h4,6-10,21-22H,3,5H2,1-2H3/b13-4+
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n/an/a 3.60E+4n/an/an/an/an/an/a



THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

US Patent


Assay Description
The bacterial cytoskeletal protein FtsZ is a GTPase and has structural homology to the eukaryotic cytoskeletal protein tubulin, but lacks significant...


US Patent US9169182 (2015)


BindingDB Entry DOI: 10.7270/Q22Z149Z
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM186046
PNG
(US9169182, J24)
Show SMILES Oc1cc(O)cc(C\C(Cl)=C/Cc2cc(O)c(Cl)cc2O)c1
Show InChI InChI=1S/C16H14Cl2O4/c17-11(3-9-4-12(19)7-13(20)5-9)2-1-10-6-16(22)14(18)8-15(10)21/h2,4-8,19-22H,1,3H2/b11-2+
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n/an/a 1.60E+5n/an/an/an/an/an/a



THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

US Patent


Assay Description
The bacterial cytoskeletal protein FtsZ is a GTPase and has structural homology to the eukaryotic cytoskeletal protein tubulin, but lacks significant...


US Patent US9169182 (2015)


BindingDB Entry DOI: 10.7270/Q22Z149Z
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Staphylococcus aureus)
BDBM50439496
PNG
(CHEMBL2418096 | US9169182, J23)
Show SMILES COc1cc(C\C=C(\Cl)Cc2cc(O)cc(O)c2)c(OC)cc1Cl
Show InChI InChI=1S/C18H18Cl2O4/c1-23-17-10-16(20)18(24-2)8-12(17)3-4-13(19)5-11-6-14(21)9-15(22)7-11/h4,6-10,21-22H,3,5H2,1-2H3/b13-4+
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n/an/a 3.80E+4n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus FtsZ GTPase activity


Eur J Med Chem 95: 1-15 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.026
BindingDB Entry DOI: 10.7270/Q2S75J14
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Staphylococcus aureus)
BDBM50079356
PNG
(CHEMBL511201)
Show SMILES NC(=O)c1c(F)ccc(OCc2nc3cc(Cl)cnc3s2)c1F
Show InChI InChI=1S/C14H8ClF2N3O2S/c15-6-3-8-14(19-4-6)23-10(20-8)5-22-9-2-1-7(16)11(12(9)17)13(18)21/h1-4H,5H2,(H2,18,21)
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n/an/a 55n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus FtsZ GTPase activity


Eur J Med Chem 95: 1-15 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.026
BindingDB Entry DOI: 10.7270/Q2S75J14
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Cell division protein FtsZ


(Escherichia coli)
BDBM50079358
PNG
(CHEMBL3416948)
Show SMILES CN(C)CCNc1nc(\C=C\c2ccc(Cl)cc2)nc2cc3ccccc3cc12
Show InChI InChI=1S/C24H23ClN4/c1-29(2)14-13-26-24-21-15-18-5-3-4-6-19(18)16-22(21)27-23(28-24)12-9-17-7-10-20(25)11-8-17/h3-12,15-16H,13-14H2,1-2H3,(H,26,27,28)/b12-9+
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n/an/a 1.20E+4n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ


Eur J Med Chem 95: 1-15 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.026
BindingDB Entry DOI: 10.7270/Q2S75J14
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50203065
PNG
(3-phenylacrylaldehyde | 3-phenylprop-2-enal | CHEM...)
Show SMILES O=C\C=C\c1ccccc1
Show InChI InChI=1S/C9H8O/c10-8-4-7-9-5-2-1-3-6-9/h1-8H/b7-4+
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n/an/a 6.86E+3n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ polymerization


Eur J Med Chem 95: 1-15 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.026
BindingDB Entry DOI: 10.7270/Q2S75J14
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50079359
PNG
(VIRIDITOXIN | Viriditoxin)
Show SMILES COC(=O)CC1Cc2cc3cc(OC)c(c(O)c3c(O)c2C(=O)O1)-c1c(OC)cc2cc3CC(CC(=O)OC)OC(=O)c3c(O)c2c1O
Show InChI InChI=1S/C34H30O14/c1-43-19-9-15-5-13-7-17(11-21(35)45-3)47-33(41)25(13)29(37)23(15)31(39)27(19)28-20(44-2)10-16-6-14-8-18(12-22(36)46-4)48-34(42)26(14)30(38)24(16)32(28)40/h5-6,9-10,17-18,37-40H,7-8,11-12H2,1-4H3
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n/an/a 8.20n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ polymerization


Eur J Med Chem 95: 1-15 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.026
BindingDB Entry DOI: 10.7270/Q2S75J14
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50203065
PNG
(3-phenylacrylaldehyde | 3-phenylprop-2-enal | CHEM...)
Show SMILES O=C\C=C\c1ccccc1
Show InChI InChI=1S/C9H8O/c10-8-4-7-9-5-2-1-3-6-9/h1-8H/b7-4+
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n/an/a 5.81E+3n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity


Eur J Med Chem 95: 1-15 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.026
BindingDB Entry DOI: 10.7270/Q2S75J14
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50079359
PNG
(VIRIDITOXIN | Viriditoxin)
Show SMILES COC(=O)CC1Cc2cc3cc(OC)c(c(O)c3c(O)c2C(=O)O1)-c1c(OC)cc2cc3CC(CC(=O)OC)OC(=O)c3c(O)c2c1O
Show InChI InChI=1S/C34H30O14/c1-43-19-9-15-5-13-7-17(11-21(35)45-3)47-33(41)25(13)29(37)23(15)31(39)27(19)28-20(44-2)10-16-6-14-8-18(12-22(36)46-4)48-34(42)26(14)30(38)24(16)32(28)40/h5-6,9-10,17-18,37-40H,7-8,11-12H2,1-4H3
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n/an/a 7n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity


Eur J Med Chem 95: 1-15 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.026
BindingDB Entry DOI: 10.7270/Q2S75J14
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50079360
PNG
(CHEBI:69681 | DICHAMANETIN | Dichamanetin)
Show SMILES Oc1ccccc1Cc1c(O)c(Cc2ccccc2O)c2O[C@@H](CC(=O)c2c1O)c1ccccc1
Show InChI InChI=1S/C29H24O6/c30-22-12-6-4-10-18(22)14-20-27(33)21(15-19-11-5-7-13-23(19)31)29-26(28(20)34)24(32)16-25(35-29)17-8-2-1-3-9-17/h1-13,25,30-31,33-34H,14-16H2/t25-/m0/s1
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n/an/a 1.25E+4n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity


Eur J Med Chem 95: 1-15 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.026
BindingDB Entry DOI: 10.7270/Q2S75J14
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50079361
PNG
(CHEMBL3416824)
Show SMILES Oc1ccccc1Cc1ccc(O)c(Cc2c(O)c(Cc3cc(Cc4ccccc4O)ccc3O)c3O[C@@H](CC(=O)c3c2O)c2ccccc2)c1
Show InChI InChI=1S/C43H36O8/c44-34-12-6-4-10-28(34)18-25-14-16-36(46)30(20-25)22-32-41(49)33(23-31-21-26(15-17-37(31)47)19-29-11-5-7-13-35(29)45)43-40(42(32)50)38(48)24-39(51-43)27-8-2-1-3-9-27/h1-17,20-21,39,44-47,49-50H,18-19,22-24H2/t39-/m0/s1
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n/an/a 8.30E+3n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity


Eur J Med Chem 95: 1-15 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.026
BindingDB Entry DOI: 10.7270/Q2S75J14
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50439495
PNG
(CHEMBL2418095)
Show SMILES Oc1cc(O)c2Oc3cc(C\C=C(Cl)/Cc4cc(O)c(Oc5cc(C\C=C(Cl)/Cc2c1)c(O)cc5Cl)c(O)c4)c(O)cc3Cl
Show InChI InChI=1S/C32H24Cl4O8/c33-19-3-1-16-10-29(22(35)13-24(16)38)43-31-18(9-21(37)12-28(31)42)8-20(34)4-2-17-11-30(23(36)14-25(17)39)44-32-26(40)6-15(5-19)7-27(32)41/h3-4,6-7,9-14,37-42H,1-2,5,8H2/b19-3+,20-4+
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n/an/a 6.70n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity


Eur J Med Chem 95: 1-15 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.026
BindingDB Entry DOI: 10.7270/Q2S75J14
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50439496
PNG
(CHEMBL2418096 | US9169182, J23)
Show SMILES COc1cc(C\C=C(\Cl)Cc2cc(O)cc(O)c2)c(OC)cc1Cl
Show InChI InChI=1S/C18H18Cl2O4/c1-23-17-10-16(20)18(24-2)8-12(17)3-4-13(19)5-11-6-14(21)9-15(22)7-11/h4,6-10,21-22H,3,5H2,1-2H3/b13-4+
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n/an/a 3.70E+4n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity


Eur J Med Chem 95: 1-15 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.026
BindingDB Entry DOI: 10.7270/Q2S75J14
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Staphylococcus aureus)
BDBM50079356
PNG
(CHEMBL511201)
Show SMILES NC(=O)c1c(F)ccc(OCc2nc3cc(Cl)cnc3s2)c1F
Show InChI InChI=1S/C14H8ClF2N3O2S/c15-6-3-8-14(19-4-6)23-10(20-8)5-22-9-2-1-7(16)11(12(9)17)13(18)21/h1-4H,5H2,(H2,18,21)
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n/an/an/an/a 4.00E+3n/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Activation of Staphylococcus aureus FtsZ GTPase activity


ACS Med Chem Lett 6: 308-12 (2015)


Article DOI: 10.1021/ml500497s
BindingDB Entry DOI: 10.7270/Q2PV6N4C
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Cell division protein ftsZ


(Bacillus subtilis)
BDBM50085931
PNG
(CHEMBL3425688)
Show SMILES CN(C)CCNc1nc(nc2ccc(C)cc12)-c1cccs1
Show InChI InChI=1S/C17H20N4S/c1-12-6-7-14-13(11-12)16(18-8-9-21(2)3)20-17(19-14)15-5-4-10-22-15/h4-7,10-11H,8-9H2,1-3H3,(H,18,19,20)
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n/an/a>1.28E+5n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Bacillus subtilis FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


ACS Med Chem Lett 6: 308-12 (2015)


Article DOI: 10.1021/ml500497s
BindingDB Entry DOI: 10.7270/Q2PV6N4C
More data for this
Ligand-Target Pair
Cell division protein ftsZ


(Bacillus subtilis)
BDBM50085932
PNG
(CHEMBL3425687)
Show SMILES CN(C)CCNc1nc(nc2ccc(C)cc12)-c1cc2ccccc2o1
Show InChI InChI=1S/C21H22N4O/c1-14-8-9-17-16(12-14)20(22-10-11-25(2)3)24-21(23-17)19-13-15-6-4-5-7-18(15)26-19/h4-9,12-13H,10-11H2,1-3H3,(H,22,23,24)
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n/an/a>1.28E+5n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Bacillus subtilis FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


ACS Med Chem Lett 6: 308-12 (2015)


Article DOI: 10.1021/ml500497s
BindingDB Entry DOI: 10.7270/Q2PV6N4C
More data for this
Ligand-Target Pair
Cell division protein ftsZ


(Bacillus subtilis)
BDBM50085934
PNG
(CHEMBL3425686)
Show SMILES CN(C)CCNc1nc(nc2ccc(C)cc12)-c1ccc2ccccc2c1
Show InChI InChI=1S/C23H24N4/c1-16-8-11-21-20(14-16)23(24-12-13-27(2)3)26-22(25-21)19-10-9-17-6-4-5-7-18(17)15-19/h4-11,14-15H,12-13H2,1-3H3,(H,24,25,26)
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n/an/a>1.28E+5n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Bacillus subtilis FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


ACS Med Chem Lett 6: 308-12 (2015)


Article DOI: 10.1021/ml500497s
BindingDB Entry DOI: 10.7270/Q2PV6N4C
More data for this
Ligand-Target Pair
Cell division protein ftsZ


(Bacillus subtilis)
BDBM50085935
PNG
(CHEMBL3425685)
Show SMILES COc1ccc(cc1)-c1nc(NCCN(C)C)c2cc(C)ccc2n1
Show InChI InChI=1S/C20H24N4O/c1-14-5-10-18-17(13-14)20(21-11-12-24(2)3)23-19(22-18)15-6-8-16(25-4)9-7-15/h5-10,13H,11-12H2,1-4H3,(H,21,22,23)
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n/an/a>1.28E+5n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Bacillus subtilis FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


ACS Med Chem Lett 6: 308-12 (2015)


Article DOI: 10.1021/ml500497s
BindingDB Entry DOI: 10.7270/Q2PV6N4C
More data for this
Ligand-Target Pair
Cell division protein ftsZ


(Bacillus subtilis)
BDBM50085936
PNG
(CHEMBL3425684)
Show SMILES CN(C)CCNc1nc(nc2ccc(C)cc12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C19H21ClN4/c1-13-4-9-17-16(12-13)19(21-10-11-24(2)3)23-18(22-17)14-5-7-15(20)8-6-14/h4-9,12H,10-11H2,1-3H3,(H,21,22,23)
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n/an/a>1.28E+5n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Bacillus subtilis FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


ACS Med Chem Lett 6: 308-12 (2015)


Article DOI: 10.1021/ml500497s
BindingDB Entry DOI: 10.7270/Q2PV6N4C
More data for this
Ligand-Target Pair
Cell division protein ftsZ


(Bacillus subtilis)
BDBM50085937
PNG
(CHEMBL3425683)
Show SMILES CN(C)CCNc1nc(N)nc2ccc(C)cc12
Show InChI InChI=1S/C13H19N5/c1-9-4-5-11-10(8-9)12(17-13(14)16-11)15-6-7-18(2)3/h4-5,8H,6-7H2,1-3H3,(H3,14,15,16,17)
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n/an/a>1.28E+5n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Bacillus subtilis FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


ACS Med Chem Lett 6: 308-12 (2015)


Article DOI: 10.1021/ml500497s
BindingDB Entry DOI: 10.7270/Q2PV6N4C
More data for this
Ligand-Target Pair
Cell division protein ftsZ


(Bacillus subtilis)
BDBM50085995
PNG
(CHEMBL3425682)
Show SMILES CN(C)CCNc1nc(NCc2ccc(Cl)cc2)nc2ccc(C)cc12
Show InChI InChI=1S/C20H24ClN5/c1-14-4-9-18-17(12-14)19(22-10-11-26(2)3)25-20(24-18)23-13-15-5-7-16(21)8-6-15/h4-9,12H,10-11,13H2,1-3H3,(H2,22,23,24,25)
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n/an/a>1.28E+5n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Bacillus subtilis FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


ACS Med Chem Lett 6: 308-12 (2015)


Article DOI: 10.1021/ml500497s
BindingDB Entry DOI: 10.7270/Q2PV6N4C
More data for this
Ligand-Target Pair
Cell division protein ftsZ


(Bacillus subtilis)
BDBM50086040
PNG
(CHEMBL3425681)
Show SMILES CN(C)CCNc1nc(NCc2ccccc2)nc2ccc(C)cc12
Show InChI InChI=1S/C20H25N5/c1-15-9-10-18-17(13-15)19(21-11-12-25(2)3)24-20(23-18)22-14-16-7-5-4-6-8-16/h4-10,13H,11-12,14H2,1-3H3,(H2,21,22,23,24)
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n/an/a>1.28E+5n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Bacillus subtilis FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


ACS Med Chem Lett 6: 308-12 (2015)


Article DOI: 10.1021/ml500497s
BindingDB Entry DOI: 10.7270/Q2PV6N4C
More data for this
Ligand-Target Pair
Cell division protein ftsZ


(Bacillus subtilis)
BDBM50086041
PNG
(CHEMBL3425680)
Show SMILES CN(C)CCNc1nc(\C=C\c2ccc(I)cc2)nc2ccc(C)cc12
Show InChI InChI=1S/C21H23IN4/c1-15-4-10-19-18(14-15)21(23-12-13-26(2)3)25-20(24-19)11-7-16-5-8-17(22)9-6-16/h4-11,14H,12-13H2,1-3H3,(H,23,24,25)/b11-7+
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n/an/a>1.28E+5n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Bacillus subtilis FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


ACS Med Chem Lett 6: 308-12 (2015)


Article DOI: 10.1021/ml500497s
BindingDB Entry DOI: 10.7270/Q2PV6N4C
More data for this
Ligand-Target Pair
Cell division protein ftsZ


(Bacillus subtilis)
BDBM50086043
PNG
(CHEMBL3425679)
Show SMILES CN(C)CCNc1nc(\C=C\c2ccc(Br)cc2)nc2ccc(C)cc12
Show InChI InChI=1S/C21H23BrN4/c1-15-4-10-19-18(14-15)21(23-12-13-26(2)3)25-20(24-19)11-7-16-5-8-17(22)9-6-16/h4-11,14H,12-13H2,1-3H3,(H,23,24,25)/b11-7+
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n/an/a>1.28E+5n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Bacillus subtilis FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


ACS Med Chem Lett 6: 308-12 (2015)


Article DOI: 10.1021/ml500497s
BindingDB Entry DOI: 10.7270/Q2PV6N4C
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086098
PNG
(CHEMBL3425705)
Show SMILES CN(C)CCNc1nc(\C=C\c2ccc(I)cc2)nc2cc3ccccc3cc12
Show InChI InChI=1S/C24H23IN4/c1-29(2)14-13-26-24-21-15-18-5-3-4-6-19(18)16-22(21)27-23(28-24)12-9-17-7-10-20(25)11-8-17/h3-12,15-16H,13-14H2,1-2H3,(H,26,27,28)/b12-9+
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n/an/a 2.40E+4n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


ACS Med Chem Lett 6: 308-12 (2015)


Article DOI: 10.1021/ml500497s
BindingDB Entry DOI: 10.7270/Q2PV6N4C
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086105
PNG
(CHEMBL3425704)
Show SMILES CN(C)CCNc1nc(\C=C\c2ccc(Cl)cc2)nc2ccc(cc12)C(=O)c1ccccc1
Show InChI InChI=1S/C27H25ClN4O/c1-32(2)17-16-29-27-23-18-21(26(33)20-6-4-3-5-7-20)11-14-24(23)30-25(31-27)15-10-19-8-12-22(28)13-9-19/h3-15,18H,16-17H2,1-2H3,(H,29,30,31)/b15-10+
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n/an/a 8.50E+4n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


ACS Med Chem Lett 6: 308-12 (2015)


Article DOI: 10.1021/ml500497s
BindingDB Entry DOI: 10.7270/Q2PV6N4C
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086107
PNG
(CHEMBL3425703)
Show SMILES CC(=O)NCCNc1nc(\C=C\c2ccc(Cl)cc2)nc2cc3ccccc3cc12
Show InChI InChI=1S/C24H21ClN4O/c1-16(30)26-12-13-27-24-21-14-18-4-2-3-5-19(18)15-22(21)28-23(29-24)11-8-17-6-9-20(25)10-7-17/h2-11,14-15H,12-13H2,1H3,(H,26,30)(H,27,28,29)/b11-8+
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n/an/a>1.28E+5n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


ACS Med Chem Lett 6: 308-12 (2015)


Article DOI: 10.1021/ml500497s
BindingDB Entry DOI: 10.7270/Q2PV6N4C
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086108
PNG
(CHEMBL3425702)
Show SMILES [NH3+]CCNc1nc(\C=C\c2ccc(Cl)cc2)nc2cc3ccccc3cc12
Show InChI InChI=1S/C22H19ClN4/c23-18-8-5-15(6-9-18)7-10-21-26-20-14-17-4-2-1-3-16(17)13-19(20)22(27-21)25-12-11-24/h1-10,13-14H,11-12,24H2,(H,25,26,27)/p+1/b10-7+
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n/an/a 9.00E+3n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


ACS Med Chem Lett 6: 308-12 (2015)


Article DOI: 10.1021/ml500497s
BindingDB Entry DOI: 10.7270/Q2PV6N4C
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086109
PNG
(CHEMBL3425701)
Show SMILES C[N+](C)(C)CCNc1nc(\C=C\c2ccc(Cl)cc2)nc2cc3ccccc3cc12
Show InChI InChI=1S/C25H26ClN4/c1-30(2,3)15-14-27-25-22-16-19-6-4-5-7-20(19)17-23(22)28-24(29-25)13-10-18-8-11-21(26)12-9-18/h4-13,16-17H,14-15H2,1-3H3,(H,27,28,29)/q+1/b13-10+
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n/an/a 5.20E+4n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


ACS Med Chem Lett 6: 308-12 (2015)


Article DOI: 10.1021/ml500497s
BindingDB Entry DOI: 10.7270/Q2PV6N4C
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086116
PNG
(CHEMBL3425700)
Show SMILES CC(C)(C)OC(=O)CNc1nc(\C=C\c2ccc(Cl)cc2)nc2cc3ccccc3cc12
Show InChI InChI=1S/C26H24ClN3O2/c1-26(2,3)32-24(31)16-28-25-21-14-18-6-4-5-7-19(18)15-22(21)29-23(30-25)13-10-17-8-11-20(27)12-9-17/h4-15H,16H2,1-3H3,(H,28,29,30)/b13-10+
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n/an/a>1.28E+5n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


ACS Med Chem Lett 6: 308-12 (2015)


Article DOI: 10.1021/ml500497s
BindingDB Entry DOI: 10.7270/Q2PV6N4C
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086118
PNG
(CHEMBL3425699)
Show SMILES CC(C)(C)OC(=O)NCCNc1nc(\C=C\c2ccc(Cl)cc2)nc2cc3ccccc3cc12
Show InChI InChI=1S/C27H27ClN4O2/c1-27(2,3)34-26(33)30-15-14-29-25-22-16-19-6-4-5-7-20(19)17-23(22)31-24(32-25)13-10-18-8-11-21(28)12-9-18/h4-13,16-17H,14-15H2,1-3H3,(H,30,33)(H,29,31,32)/b13-10+
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n/an/a>1.28E+5n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


ACS Med Chem Lett 6: 308-12 (2015)


Article DOI: 10.1021/ml500497s
BindingDB Entry DOI: 10.7270/Q2PV6N4C
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086119
PNG
(CHEMBL3425698)
Show SMILES COCCCNc1nc(\C=C\c2ccc(Cl)cc2)nc2cc3ccccc3cc12
Show InChI InChI=1S/C24H22ClN3O/c1-29-14-4-13-26-24-21-15-18-5-2-3-6-19(18)16-22(21)27-23(28-24)12-9-17-7-10-20(25)11-8-17/h2-3,5-12,15-16H,4,13-14H2,1H3,(H,26,27,28)/b12-9+
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n/an/a>1.28E+5n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


ACS Med Chem Lett 6: 308-12 (2015)


Article DOI: 10.1021/ml500497s
BindingDB Entry DOI: 10.7270/Q2PV6N4C
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086120
PNG
(CHEMBL3425697)
Show SMILES CN(C)CCCNc1nc(\C=C\c2ccc(Cl)cc2)nc2cc3ccccc3cc12
Show InChI InChI=1S/C25H25ClN4/c1-30(2)15-5-14-27-25-22-16-19-6-3-4-7-20(19)17-23(22)28-24(29-25)13-10-18-8-11-21(26)12-9-18/h3-4,6-13,16-17H,5,14-15H2,1-2H3,(H,27,28,29)/b13-10+
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n/an/a 6.50E+4n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


ACS Med Chem Lett 6: 308-12 (2015)


Article DOI: 10.1021/ml500497s
BindingDB Entry DOI: 10.7270/Q2PV6N4C
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086121
PNG
(CHEMBL3425696)
Show SMILES COCCNc1nc(\C=C\c2ccc(Cl)cc2)nc2cc3ccccc3cc12
Show InChI InChI=1S/C23H20ClN3O/c1-28-13-12-25-23-20-14-17-4-2-3-5-18(17)15-21(20)26-22(27-23)11-8-16-6-9-19(24)10-7-16/h2-11,14-15H,12-13H2,1H3,(H,25,26,27)/b11-8+
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n/an/a>1.28E+5n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


ACS Med Chem Lett 6: 308-12 (2015)


Article DOI: 10.1021/ml500497s
BindingDB Entry DOI: 10.7270/Q2PV6N4C
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086122
PNG
(CHEMBL3425695)
Show SMILES CSCCNc1nc(\C=C\c2ccc(Cl)cc2)nc2cc3ccccc3cc12
Show InChI InChI=1S/C23H20ClN3S/c1-28-13-12-25-23-20-14-17-4-2-3-5-18(17)15-21(20)26-22(27-23)11-8-16-6-9-19(24)10-7-16/h2-11,14-15H,12-13H2,1H3,(H,25,26,27)/b11-8+
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n/an/a>1.28E+5n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


ACS Med Chem Lett 6: 308-12 (2015)


Article DOI: 10.1021/ml500497s
BindingDB Entry DOI: 10.7270/Q2PV6N4C
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086123
PNG
(CHEMBL3425694)
Show SMILES CN(C)CCOc1nc(\C=C\c2ccc(Cl)cc2)nc2cc3ccccc3cc12
Show InChI InChI=1S/C24H22ClN3O/c1-28(2)13-14-29-24-21-15-18-5-3-4-6-19(18)16-22(21)26-23(27-24)12-9-17-7-10-20(25)11-8-17/h3-12,15-16H,13-14H2,1-2H3/b12-9+
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n/an/a 2.60E+4n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


ACS Med Chem Lett 6: 308-12 (2015)


Article DOI: 10.1021/ml500497s
BindingDB Entry DOI: 10.7270/Q2PV6N4C
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086124
PNG
(CHEMBL3425693)
Show SMILES Cc1ccc2nc(\C=C\c3ccc(Cl)cc3)nc(NCC[NH3+])c2c1
Show InChI InChI=1S/C19H19ClN4/c1-13-2-8-17-16(12-13)19(22-11-10-21)24-18(23-17)9-5-14-3-6-15(20)7-4-14/h2-9,12H,10-11,21H2,1H3,(H,22,23,24)/p+1/b9-5+
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n/an/a 2.70E+4n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


ACS Med Chem Lett 6: 308-12 (2015)


Article DOI: 10.1021/ml500497s
BindingDB Entry DOI: 10.7270/Q2PV6N4C
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086125
PNG
(CHEMBL3425692)
Show SMILES Cc1ccc2nc(\C=C\c3ccc(Cl)cc3)nc(NCCNC(=O)OC(C)(C)C)c2c1
Show InChI InChI=1S/C24H27ClN4O2/c1-16-5-11-20-19(15-16)22(26-13-14-27-23(30)31-24(2,3)4)29-21(28-20)12-8-17-6-9-18(25)10-7-17/h5-12,15H,13-14H2,1-4H3,(H,27,30)(H,26,28,29)/b12-8+
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n/an/a>1.28E+5n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


ACS Med Chem Lett 6: 308-12 (2015)


Article DOI: 10.1021/ml500497s
BindingDB Entry DOI: 10.7270/Q2PV6N4C
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086180
PNG
(CHEMBL3425691)
Show SMILES COCCNc1nc(\C=C\c2ccc(Cl)cc2)nc2ccc(C)cc12
Show InChI InChI=1S/C20H20ClN3O/c1-14-3-9-18-17(13-14)20(22-11-12-25-2)24-19(23-18)10-6-15-4-7-16(21)8-5-15/h3-10,13H,11-12H2,1-2H3,(H,22,23,24)/b10-6+
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n/an/a>1.28E+5n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


ACS Med Chem Lett 6: 308-12 (2015)


Article DOI: 10.1021/ml500497s
BindingDB Entry DOI: 10.7270/Q2PV6N4C
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086191
PNG
(CHEMBL3425690)
Show SMILES CN(C)CCNc1nc(nc2ccc(C)cc12)C(=O)NCc1ccc(Cl)cc1
Show InChI InChI=1S/C21H24ClN5O/c1-14-4-9-18-17(12-14)19(23-10-11-27(2)3)26-20(25-18)21(28)24-13-15-5-7-16(22)8-6-15/h4-9,12H,10-11,13H2,1-3H3,(H,24,28)(H,23,25,26)
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n/an/a>1.28E+5n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


ACS Med Chem Lett 6: 308-12 (2015)


Article DOI: 10.1021/ml500497s
BindingDB Entry DOI: 10.7270/Q2PV6N4C
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086196
PNG
(CHEMBL3425689)
Show SMILES Cc1ccc2nc(nc(NCC[NH3+])c2c1)C(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C18H18ClN5O/c1-11-2-7-15-14(10-11)16(21-9-8-20)24-17(23-15)18(25)22-13-5-3-12(19)4-6-13/h2-7,10H,8-9,20H2,1H3,(H,22,25)(H,21,23,24)/p+1
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PubMed
n/an/a>1.28E+5n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


ACS Med Chem Lett 6: 308-12 (2015)


Article DOI: 10.1021/ml500497s
BindingDB Entry DOI: 10.7270/Q2PV6N4C
More data for this
Ligand-Target Pair
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