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Compile Data Set for Download or QSAR

Found 806 hits Enz. Inhib. hit(s) with Target = 'Cholecystokinin A receptor'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cholecystokinin A receptor


(Cavia porcellus)
BDBM50407325
PNG
(CHEMBL408395)
Show SMILES CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NC(Cc1ccc(NC(=O)Nc2ccccc2C)cc1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](Cc1ccc(C)cc1)C(N)=O
Show InChI InChI=1S/C44H48N8O8/c1-25-12-14-28(15-13-25)20-35(40(45)56)49-43(59)38(23-39(54)55)51-41(57)36(21-29-16-18-31(19-17-29)48-44(60)52-33-10-6-4-8-26(33)2)50-42(58)37(47-27(3)53)22-30-24-46-34-11-7-5-9-32(30)34/h4-19,24,35-38,46H,20-23H2,1-3H3,(H2,45,56)(H,47,53)(H,49,59)(H,50,58)(H,51,57)(H,54,55)(H2,48,52,60)/t35-,36?,37+,38+/m1/s1
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n/an/an/a 39.8n/an/an/an/an/a



Glaxo Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity against CCK-8 induced responses in guinea pig gall bladder was determined


J Med Chem 38: 207-11 (1995)


Article DOI: 10.1021/jm00001a027
BindingDB Entry DOI: 10.7270/Q28C9XF9
More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM50407326
PNG
(CHEMBL302027)
Show SMILES CC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NC(Cc1cccc(NC(=O)Nc2ccccc2C)c1)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](Cc1ccc(C)cc1)C(N)=O
Show InChI InChI=1S/C44H48N8O8/c1-25-15-17-28(18-16-25)20-35(40(45)56)49-43(59)38(23-39(54)55)51-41(57)36(21-29-10-8-11-31(19-29)48-44(60)52-33-13-6-4-9-26(33)2)50-42(58)37(47-27(3)53)22-30-24-46-34-14-7-5-12-32(30)34/h4-19,24,35-38,46H,20-23H2,1-3H3,(H2,45,56)(H,47,53)(H,49,59)(H,50,58)(H,51,57)(H,54,55)(H2,48,52,60)/t35-,36?,37+,38+/m0/s1
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n/an/an/a 39.8n/an/an/an/an/a



Glaxo Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity against CCK-8 induced responses in guinea pig gall bladder was determined


J Med Chem 38: 207-11 (1995)


Article DOI: 10.1021/jm00001a027
BindingDB Entry DOI: 10.7270/Q28C9XF9
More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM50407327
PNG
(CHEMBL303635)
Show SMILES CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NC(Cc1cccc(NC(=O)Nc2ccccc2C)c1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](Cc1ccc(C)cc1)C(N)=O
Show InChI InChI=1S/C44H48N8O8/c1-25-15-17-28(18-16-25)20-35(40(45)56)49-43(59)38(23-39(54)55)51-41(57)36(21-29-10-8-11-31(19-29)48-44(60)52-33-13-6-4-9-26(33)2)50-42(58)37(47-27(3)53)22-30-24-46-34-14-7-5-12-32(30)34/h4-19,24,35-38,46H,20-23H2,1-3H3,(H2,45,56)(H,47,53)(H,49,59)(H,50,58)(H,51,57)(H,54,55)(H2,48,52,60)/t35-,36?,37+,38+/m1/s1
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n/an/an/a 63.1n/an/an/an/an/a



Glaxo Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity against CCK-8 induced responses in guinea pig gall bladder was determined


J Med Chem 38: 207-11 (1995)


Article DOI: 10.1021/jm00001a027
BindingDB Entry DOI: 10.7270/Q28C9XF9
More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM50407328
PNG
(CHEMBL302150)
Show SMILES CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NC(Cc1ccc(NC(=O)Nc2ccccc2Cl)cc1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](Cc1ccc(C)cc1)C(N)=O
Show InChI InChI=1S/C43H45ClN8O8/c1-24-11-13-26(14-12-24)19-34(39(45)56)49-42(59)37(22-38(54)55)51-40(57)35(20-27-15-17-29(18-16-27)48-43(60)52-33-10-6-4-8-31(33)44)50-41(58)36(47-25(2)53)21-28-23-46-32-9-5-3-7-30(28)32/h3-18,23,34-37,46H,19-22H2,1-2H3,(H2,45,56)(H,47,53)(H,49,59)(H,50,58)(H,51,57)(H,54,55)(H2,48,52,60)/t34-,35?,36+,37+/m1/s1
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n/an/an/a 79.4n/an/an/an/an/a



Glaxo Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity against CCK-8 induced responses in guinea pig gall bladder was determined


J Med Chem 38: 207-11 (1995)


Article DOI: 10.1021/jm00001a027
BindingDB Entry DOI: 10.7270/Q28C9XF9
More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM50016504
PNG
((S)-3-(2-{[(S)-2-(2-{2-[2-tert-Butoxycarbonylamino...)
Show SMILES CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS([O-])(=O)=O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C52H69N9O15S/c1-6-8-18-37(57-48(68)40(61-51(71)75-52(3,4)5)26-32-21-23-34(24-22-32)76-77(72,73)74)46(66)55-30-43(62)56-41(27-33-29-54-36-20-14-13-17-35(33)36)49(69)58-38(19-9-7-2)47(67)60-42(28-44(63)64)50(70)59-39(45(53)65)25-31-15-11-10-12-16-31/h10-17,20-24,29,37-42,54H,6-9,18-19,25-28,30H2,1-5H3,(H2,53,65)(H,55,66)(H,56,62)(H,57,68)(H,58,69)(H,59,70)(H,60,67)(H,61,71)(H,63,64)(H,72,73,74)/p-1/t37-,38-,39-,40-,41-,42-/m0/s1
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0.230n/an/an/an/an/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
The compound was tested for the inhibition of [3H]-Propionyl specific binding to Cholecystokinin 8 receptor of guinea pig brain


J Med Chem 32: 445-9 (1989)


Article DOI: 10.1021/jm00122a026
BindingDB Entry DOI: 10.7270/Q2S181GT
More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM21147
PNG
((3S)-3-[(2S)-2-[(2S)-2-{2-[(2S)-2-[(2S)-2-[(3S)-3-...)
Show SMILES CSCC[C@H](NC(=O)[C@H](Cc1ccc(OS(O)(=O)=O)cc1)NC(=O)[C@@H](N)CC(O)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C49H62N10O16S3/c1-76-18-16-34(55-47(69)37(58-44(66)32(50)23-41(61)62)21-28-12-14-30(15-13-28)75-78(72,73)74)45(67)53-26-40(60)54-38(22-29-25-52-33-11-7-6-10-31(29)33)48(70)56-35(17-19-77-2)46(68)59-39(24-42(63)64)49(71)57-36(43(51)65)20-27-8-4-3-5-9-27/h3-15,25,32,34-39,52H,16-24,26,50H2,1-2H3,(H2,51,65)(H,53,67)(H,54,60)(H,55,69)(H,56,70)(H,57,71)(H,58,66)(H,59,68)(H,61,62)(H,63,64)(H,72,73,74)/t32-,34-,35-,36-,37-,38-,39-/m0/s1
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0.280n/an/an/an/an/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Inhibition of [3H]pCCK-8 binding to Cholecystokinin type A receptor of Guinea pig pancreatic membranes


J Med Chem 40: 647-58 (1997)


Article DOI: 10.1021/jm9603072
BindingDB Entry DOI: 10.7270/Q2PG1SDX
More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM21147
PNG
((3S)-3-[(2S)-2-[(2S)-2-{2-[(2S)-2-[(2S)-2-[(3S)-3-...)
Show SMILES CSCC[C@H](NC(=O)[C@H](Cc1ccc(OS(O)(=O)=O)cc1)NC(=O)[C@@H](N)CC(O)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C49H62N10O16S3/c1-76-18-16-34(55-47(69)37(58-44(66)32(50)23-41(61)62)21-28-12-14-30(15-13-28)75-78(72,73)74)45(67)53-26-40(60)54-38(22-29-25-52-33-11-7-6-10-31(29)33)48(70)56-35(17-19-77-2)46(68)59-39(24-42(63)64)49(71)57-36(43(51)65)20-27-8-4-3-5-9-27/h3-15,25,32,34-39,52H,16-24,26,50H2,1-2H3,(H2,51,65)(H,53,67)(H,54,60)(H,55,69)(H,56,70)(H,57,71)(H,58,66)(H,59,68)(H,61,62)(H,63,64)(H,72,73,74)/t32-,34-,35-,36-,37-,38-,39-/m0/s1
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0.280n/an/an/an/an/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
The compound was tested for the inhibition of [3H]-Propionyl specific binding to CCK-8 receptor of guinea pig brain


J Med Chem 32: 445-9 (1989)


Article DOI: 10.1021/jm00122a026
BindingDB Entry DOI: 10.7270/Q2S181GT
More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM50016504
PNG
((S)-3-(2-{[(S)-2-(2-{2-[2-tert-Butoxycarbonylamino...)
Show SMILES CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS([O-])(=O)=O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C52H69N9O15S/c1-6-8-18-37(57-48(68)40(61-51(71)75-52(3,4)5)26-32-21-23-34(24-22-32)76-77(72,73)74)46(66)55-30-43(62)56-41(27-33-29-54-36-20-14-13-17-35(33)36)49(69)58-38(19-9-7-2)47(67)60-42(28-44(63)64)50(70)59-39(45(53)65)25-31-15-11-10-12-16-31/h10-17,20-24,29,37-42,54H,6-9,18-19,25-28,30H2,1-5H3,(H2,53,65)(H,55,66)(H,56,62)(H,57,68)(H,58,69)(H,59,70)(H,60,67)(H,61,71)(H,63,64)(H,72,73,74)/p-1/t37-,38-,39-,40-,41-,42-/m0/s1
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0.310n/an/an/an/an/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Ability to displace 1 nM [3H]pCCK-8 from Cholecystokinin type A receptor in guinea pig pancreatic membranes


Bioorg Med Chem Lett 14: 369-72 (2003)


Article DOI: 10.1016/j.bmcl.2003.11.001
BindingDB Entry DOI: 10.7270/Q2RJ4K1Z
More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM21147
PNG
((3S)-3-[(2S)-2-[(2S)-2-{2-[(2S)-2-[(2S)-2-[(3S)-3-...)
Show SMILES CSCC[C@H](NC(=O)[C@H](Cc1ccc(OS(O)(=O)=O)cc1)NC(=O)[C@@H](N)CC(O)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C49H62N10O16S3/c1-76-18-16-34(55-47(69)37(58-44(66)32(50)23-41(61)62)21-28-12-14-30(15-13-28)75-78(72,73)74)45(67)53-26-40(60)54-38(22-29-25-52-33-11-7-6-10-31(29)33)48(70)56-35(17-19-77-2)46(68)59-39(24-42(63)64)49(71)57-36(43(51)65)20-27-8-4-3-5-9-27/h3-15,25,32,34-39,52H,16-24,26,50H2,1-2H3,(H2,51,65)(H,53,67)(H,54,60)(H,55,69)(H,56,70)(H,57,71)(H,58,66)(H,59,68)(H,61,62)(H,63,64)(H,72,73,74)/t32-,34-,35-,36-,37-,38-,39-/m0/s1
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0.600n/an/an/an/an/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Ability to displace 1 nM [3H]pCCK-8 from Cholecystokinin type A receptor in guinea pig pancreatic membranes


Bioorg Med Chem Lett 14: 369-72 (2003)


Article DOI: 10.1016/j.bmcl.2003.11.001
BindingDB Entry DOI: 10.7270/Q2RJ4K1Z
More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM21147
PNG
((3S)-3-[(2S)-2-[(2S)-2-{2-[(2S)-2-[(2S)-2-[(3S)-3-...)
Show SMILES CSCC[C@H](NC(=O)[C@H](Cc1ccc(OS(O)(=O)=O)cc1)NC(=O)[C@@H](N)CC(O)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C49H62N10O16S3/c1-76-18-16-34(55-47(69)37(58-44(66)32(50)23-41(61)62)21-28-12-14-30(15-13-28)75-78(72,73)74)45(67)53-26-40(60)54-38(22-29-25-52-33-11-7-6-10-31(29)33)48(70)56-35(17-19-77-2)46(68)59-39(24-42(63)64)49(71)57-36(43(51)65)20-27-8-4-3-5-9-27/h3-15,25,32,34-39,52H,16-24,26,50H2,1-2H3,(H2,51,65)(H,53,67)(H,54,60)(H,55,69)(H,56,70)(H,57,71)(H,58,66)(H,59,68)(H,61,62)(H,63,64)(H,72,73,74)/t32-,34-,35-,36-,37-,38-,39-/m0/s1
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0.640n/an/an/an/an/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Displacement of 0.1 nM [3H]-pCCK-8 from guinea pig pancreatic membranes


J Med Chem 32: 1184-90 (1989)


Article DOI: 10.1021/jm00126a007
BindingDB Entry DOI: 10.7270/Q2ZG6R7N
More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM21147
PNG
((3S)-3-[(2S)-2-[(2S)-2-{2-[(2S)-2-[(2S)-2-[(3S)-3-...)
Show SMILES CSCC[C@H](NC(=O)[C@H](Cc1ccc(OS(O)(=O)=O)cc1)NC(=O)[C@@H](N)CC(O)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C49H62N10O16S3/c1-76-18-16-34(55-47(69)37(58-44(66)32(50)23-41(61)62)21-28-12-14-30(15-13-28)75-78(72,73)74)45(67)53-26-40(60)54-38(22-29-25-52-33-11-7-6-10-31(29)33)48(70)56-35(17-19-77-2)46(68)59-39(24-42(63)64)49(71)57-36(43(51)65)20-27-8-4-3-5-9-27/h3-15,25,32,34-39,52H,16-24,26,50H2,1-2H3,(H2,51,65)(H,53,67)(H,54,60)(H,55,69)(H,56,70)(H,57,71)(H,58,66)(H,59,68)(H,61,62)(H,63,64)(H,72,73,74)/t32-,34-,35-,36-,37-,38-,39-/m0/s1
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0.640n/an/an/an/an/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
The compound was tested for the inhibition of [3H]-Propionyl specific binding to Cholecystokinin 8 receptor of guinea pig brain


J Med Chem 32: 445-9 (1989)


Article DOI: 10.1021/jm00122a026
BindingDB Entry DOI: 10.7270/Q2S181GT
More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM21147
PNG
((3S)-3-[(2S)-2-[(2S)-2-{2-[(2S)-2-[(2S)-2-[(3S)-3-...)
Show SMILES CSCC[C@H](NC(=O)[C@H](Cc1ccc(OS(O)(=O)=O)cc1)NC(=O)[C@@H](N)CC(O)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C49H62N10O16S3/c1-76-18-16-34(55-47(69)37(58-44(66)32(50)23-41(61)62)21-28-12-14-30(15-13-28)75-78(72,73)74)45(67)53-26-40(60)54-38(22-29-25-52-33-11-7-6-10-31(29)33)48(70)56-35(17-19-77-2)46(68)59-39(24-42(63)64)49(71)57-36(43(51)65)20-27-8-4-3-5-9-27/h3-15,25,32,34-39,52H,16-24,26,50H2,1-2H3,(H2,51,65)(H,53,67)(H,54,60)(H,55,69)(H,56,70)(H,57,71)(H,58,66)(H,59,68)(H,61,62)(H,63,64)(H,72,73,74)/t32-,34-,35-,36-,37-,38-,39-/m0/s1
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0.640n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested for the inhibition of [3H]-pCCK-8 binding to Cholecystokinin type A receptor in pancreatic membranes of guinea-pig


Bioorg Med Chem Lett 3: 847-850 (1993)


Article DOI: 10.1016/S0960-894X(00)80678-2
BindingDB Entry DOI: 10.7270/Q2P26Z28
More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM50092405
PNG
((S)-N-((S)-1-Carbamoyl-2-phenyl-ethyl)-3-((S)-2-{[...)
Show SMILES CCCC[C@H](N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C34H42N6O9/c1-3-4-14-27(33(48)39-25(17-29(42)43)32(47)38-24(31(35)46)15-20-10-6-5-7-11-20)40(2)34(49)26(37-28(41)18-30(44)45)16-21-19-36-23-13-9-8-12-22(21)23/h5-13,19,24-27,36H,3-4,14-18H2,1-2H3,(H2,35,46)(H,37,41)(H,38,47)(H,39,48)(H,42,43)(H,44,45)/t24-,25-,26-,27-/m0/s1
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>0.700n/an/an/an/an/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Affinity against Cholecystokinin type A receptor on guinea pig pancreatic membranes.


J Med Chem 43: 3614-23 (2000)


Article DOI: 10.1021/jm0000416
BindingDB Entry DOI: 10.7270/Q2RN373C
More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM50092398
PNG
((S)-3-((S)-2-{[(S)-2-tert-Butoxycarbonylamino-3-(1...)
Show SMILES CCCC[C@H](N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C36H48N6O8/c1-6-7-17-29(33(47)40-27(20-30(43)44)32(46)39-26(31(37)45)18-22-13-9-8-10-14-22)42(5)34(48)28(41-35(49)50-36(2,3)4)19-23-21-38-25-16-12-11-15-24(23)25/h8-16,21,26-29,38H,6-7,17-20H2,1-5H3,(H2,37,45)(H,39,46)(H,40,47)(H,41,49)(H,43,44)/t26-,27-,28-,29-/m0/s1
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>0.700n/an/an/an/an/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Affinity against Cholecystokinin type A receptor on guinea pig pancreatic membranes.


J Med Chem 43: 3614-23 (2000)


Article DOI: 10.1021/jm0000416
BindingDB Entry DOI: 10.7270/Q2RN373C
More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM21147
PNG
((3S)-3-[(2S)-2-[(2S)-2-{2-[(2S)-2-[(2S)-2-[(3S)-3-...)
Show SMILES CSCC[C@H](NC(=O)[C@H](Cc1ccc(OS(O)(=O)=O)cc1)NC(=O)[C@@H](N)CC(O)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C49H62N10O16S3/c1-76-18-16-34(55-47(69)37(58-44(66)32(50)23-41(61)62)21-28-12-14-30(15-13-28)75-78(72,73)74)45(67)53-26-40(60)54-38(22-29-25-52-33-11-7-6-10-31(29)33)48(70)56-35(17-19-77-2)46(68)59-39(24-42(63)64)49(71)57-36(43(51)65)20-27-8-4-3-5-9-27/h3-15,25,32,34-39,52H,16-24,26,50H2,1-2H3,(H2,51,65)(H,53,67)(H,54,60)(H,55,69)(H,56,70)(H,57,71)(H,58,66)(H,59,68)(H,61,62)(H,63,64)(H,72,73,74)/t32-,34-,35-,36-,37-,38-,39-/m0/s1
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0.700n/an/an/an/an/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Compound was tested for binding affinity against CCK1 (cholecystokinin) receptor on guinea pig pancreatic membranes


J Med Chem 43: 3614-23 (2000)


Article DOI: 10.1021/jm0000416
BindingDB Entry DOI: 10.7270/Q2RN373C
More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM21147
PNG
((3S)-3-[(2S)-2-[(2S)-2-{2-[(2S)-2-[(2S)-2-[(3S)-3-...)
Show SMILES CSCC[C@H](NC(=O)[C@H](Cc1ccc(OS(O)(=O)=O)cc1)NC(=O)[C@@H](N)CC(O)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C49H62N10O16S3/c1-76-18-16-34(55-47(69)37(58-44(66)32(50)23-41(61)62)21-28-12-14-30(15-13-28)75-78(72,73)74)45(67)53-26-40(60)54-38(22-29-25-52-33-11-7-6-10-31(29)33)48(70)56-35(17-19-77-2)46(68)59-39(24-42(63)64)49(71)57-36(43(51)65)20-27-8-4-3-5-9-27/h3-15,25,32,34-39,52H,16-24,26,50H2,1-2H3,(H2,51,65)(H,53,67)(H,54,60)(H,55,69)(H,56,70)(H,57,71)(H,58,66)(H,59,68)(H,61,62)(H,63,64)(H,72,73,74)/t32-,34-,35-,36-,37-,38-,39-/m0/s1
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0.700n/an/an/an/an/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Displacement of [3H]-pCCK-8 from cholecystokinin-A receptor in guinea pig pancreatic membrane


J Med Chem 36: 166-72 (1993)


Article DOI: 10.1021/jm00053a022
BindingDB Entry DOI: 10.7270/Q26M37FJ
More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM50092405
PNG
((S)-N-((S)-1-Carbamoyl-2-phenyl-ethyl)-3-((S)-2-{[...)
Show SMILES CCCC[C@H](N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C34H42N6O9/c1-3-4-14-27(33(48)39-25(17-29(42)43)32(47)38-24(31(35)46)15-20-10-6-5-7-11-20)40(2)34(49)26(37-28(41)18-30(44)45)16-21-19-36-23-13-9-8-12-22(21)23/h5-13,19,24-27,36H,3-4,14-18H2,1-2H3,(H2,35,46)(H,37,41)(H,38,47)(H,39,48)(H,42,43)(H,44,45)/t24-,25-,26-,27-/m0/s1
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0.75n/an/an/an/an/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Ability to displace 1 nM [3H]pCCK-8 from Cholecystokinin type A receptor in guinea pig pancreatic membranes


Bioorg Med Chem Lett 14: 369-72 (2003)


Article DOI: 10.1016/j.bmcl.2003.11.001
BindingDB Entry DOI: 10.7270/Q2RJ4K1Z
More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM50016425
PNG
((S)-3-{(S)-2-[(S)-2-(2-{(S)-2-[(S)-2-tert-Butoxyca...)
Show SMILES CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(O)(=O)=O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C52H69N9O15S/c1-6-8-18-37(57-48(68)40(61-51(71)75-52(3,4)5)26-32-21-23-34(24-22-32)76-77(72,73)74)46(66)55-30-43(62)56-41(27-33-29-54-36-20-14-13-17-35(33)36)49(69)58-38(19-9-7-2)47(67)60-42(28-44(63)64)50(70)59-39(45(53)65)25-31-15-11-10-12-16-31/h10-17,20-24,29,37-42,54H,6-9,18-19,25-28,30H2,1-5H3,(H2,53,65)(H,55,66)(H,56,62)(H,57,68)(H,58,69)(H,59,70)(H,60,67)(H,61,71)(H,63,64)(H,72,73,74)/t37-,38-,39-,40-,41-,42-/m0/s1
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0.930n/an/an/an/an/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Displacement of 0.1 nM [3H]-pCCK-8 from guinea pig pancreatic membranes


J Med Chem 32: 1184-90 (1989)


Article DOI: 10.1021/jm00126a007
BindingDB Entry DOI: 10.7270/Q2ZG6R7N
More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM50016504
PNG
((S)-3-(2-{[(S)-2-(2-{2-[2-tert-Butoxycarbonylamino...)
Show SMILES CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS([O-])(=O)=O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C52H69N9O15S/c1-6-8-18-37(57-48(68)40(61-51(71)75-52(3,4)5)26-32-21-23-34(24-22-32)76-77(72,73)74)46(66)55-30-43(62)56-41(27-33-29-54-36-20-14-13-17-35(33)36)49(69)58-38(19-9-7-2)47(67)60-42(28-44(63)64)50(70)59-39(45(53)65)25-31-15-11-10-12-16-31/h10-17,20-24,29,37-42,54H,6-9,18-19,25-28,30H2,1-5H3,(H2,53,65)(H,55,66)(H,56,62)(H,57,68)(H,58,69)(H,59,70)(H,60,67)(H,61,71)(H,63,64)(H,72,73,74)/p-1/t37-,38-,39-,40-,41-,42-/m0/s1
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0.930n/an/an/an/an/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
The compound was tested for the inhibition of [3H]-Propionyl specific binding to Cholecystokinin 8 receptor of guinea pig pancreatic membrane


J Med Chem 32: 445-9 (1989)


Article DOI: 10.1021/jm00122a026
BindingDB Entry DOI: 10.7270/Q2S181GT
More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM50092388
PNG
(3-(2-{[2-(3-tert-Butoxycarbonylamino-propionylamin...)
Show SMILES CCCC[C@H](N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C39H53N7O9/c1-6-7-17-31(36(52)45-29(22-33(48)49)35(51)44-28(34(40)50)20-24-13-9-8-10-14-24)46(5)37(53)30(21-25-23-42-27-16-12-11-15-26(25)27)43-32(47)18-19-41-38(54)55-39(2,3)4/h8-16,23,28-31,42H,6-7,17-22H2,1-5H3,(H2,40,50)(H,41,54)(H,43,47)(H,44,51)(H,45,52)(H,48,49)/t28-,29-,30-,31-/m0/s1
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1.35n/an/an/an/an/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Affinity against Cholecystokinin type A receptor on guinea pig pancreatic membranes.


J Med Chem 43: 3614-23 (2000)


Article DOI: 10.1021/jm0000416
BindingDB Entry DOI: 10.7270/Q2RN373C
More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM50016506
PNG
(CHEMBL262687 | Sodium; (4-{2-(2-acetylamino-3-carb...)
Show SMILES CCCC[C@H](NC(=O)[C@H](Cc1ccc(CS([O-])(=O)=O)cc1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C50H65N9O13S/c1-4-6-16-37(56-48(67)40(54-30(3)60)24-32-19-21-33(22-20-32)29-73(70,71)72)46(65)53-28-43(61)55-41(25-34-27-52-36-18-12-11-15-35(34)36)49(68)57-38(17-7-5-2)47(66)59-42(26-44(62)63)50(69)58-39(45(51)64)23-31-13-9-8-10-14-31/h8-15,18-22,27,37-42,52H,4-7,16-17,23-26,28-29H2,1-3H3,(H2,51,64)(H,53,65)(H,54,60)(H,55,61)(H,56,67)(H,57,68)(H,58,69)(H,59,66)(H,62,63)(H,70,71,72)/p-1/t37-,38-,39-,40-,41-,42-/m0/s1
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1.70n/an/an/an/an/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
The compound was tested for the inhibition of [3H]-Propionyl specific binding to Cholecystokinin 8 receptor of guinea pig pancreatic membrane


J Med Chem 32: 445-9 (1989)


Article DOI: 10.1021/jm00122a026
BindingDB Entry DOI: 10.7270/Q2S181GT
More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM50092391
PNG
(3-(2-{[2-(2-Carbamoyl-acetylamino)-3-(1H-indol-3-y...)
Show SMILES CCCC[C@H](N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C34H43N7O8/c1-3-4-14-27(33(48)40-25(17-30(44)45)32(47)39-24(31(36)46)15-20-10-6-5-7-11-20)41(2)34(49)26(38-29(43)18-28(35)42)16-21-19-37-23-13-9-8-12-22(21)23/h5-13,19,24-27,37H,3-4,14-18H2,1-2H3,(H2,35,42)(H2,36,46)(H,38,43)(H,39,47)(H,40,48)(H,44,45)/t24-,25-,26-,27-/m0/s1
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2.05n/an/an/an/an/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Affinity against Cholecystokinin type A receptor on guinea pig pancreatic membranes.


J Med Chem 43: 3614-23 (2000)


Article DOI: 10.1021/jm0000416
BindingDB Entry DOI: 10.7270/Q2RN373C
More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM50092398
PNG
((S)-3-((S)-2-{[(S)-2-tert-Butoxycarbonylamino-3-(1...)
Show SMILES CCCC[C@H](N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C36H48N6O8/c1-6-7-17-29(33(47)40-27(20-30(43)44)32(46)39-26(31(37)45)18-22-13-9-8-10-14-22)42(5)34(48)28(41-35(49)50-36(2,3)4)19-23-21-38-25-16-12-11-15-24(23)25/h8-16,21,26-29,38H,6-7,17-20H2,1-5H3,(H2,37,45)(H,39,46)(H,40,47)(H,41,49)(H,43,44)/t26-,27-,28-,29-/m0/s1
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2.60n/an/an/an/an/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Ability to displace 1 nM [3H]pCCK-8 from Cholecystokinin type A receptor in guinea pig pancreatic membranes


Bioorg Med Chem Lett 14: 369-72 (2003)


Article DOI: 10.1016/j.bmcl.2003.11.001
BindingDB Entry DOI: 10.7270/Q2RJ4K1Z
More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM50092396
PNG
(3-(2-{[2-Amino-3-(1H-indol-3-yl)-propionyl]-methyl...)
Show SMILES CCCC[C@H](N(C)C(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C31H40N6O6/c1-3-4-14-26(37(2)31(43)22(32)16-20-18-34-23-13-9-8-12-21(20)23)30(42)36-25(17-27(38)39)29(41)35-24(28(33)40)15-19-10-6-5-7-11-19/h5-13,18,22,24-26,34H,3-4,14-17,32H2,1-2H3,(H2,33,40)(H,35,41)(H,36,42)(H,38,39)/t22-,24-,25-,26-/m0/s1
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2.60n/an/an/an/an/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Affinity against Cholecystokinin type A receptor on guinea pig pancreatic membranes.


J Med Chem 43: 3614-23 (2000)


Article DOI: 10.1021/jm0000416
BindingDB Entry DOI: 10.7270/Q2RN373C
More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM50138278
PNG
((S)-N-((S)-1-Carbamoyl-2-phenyl-ethyl)-3-((S)-2-{[...)
Show SMILES CCCCCNC(=O)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@@H](CCCC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C39H53N7O8/c1-4-6-13-19-41-33(47)23-34(48)43-31(21-26-24-42-28-17-12-11-16-27(26)28)39(54)46(3)32(18-7-5-2)38(53)45-30(22-35(49)50)37(52)44-29(36(40)51)20-25-14-9-8-10-15-25/h8-12,14-17,24,29-32,42H,4-7,13,18-23H2,1-3H3,(H2,40,51)(H,41,47)(H,43,48)(H,44,52)(H,45,53)(H,49,50)/t29-,30-,31-,32-/m0/s1
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2.70n/an/an/an/an/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Ability to displace 1 nM [3H]pCCK-8 from Cholecystokinin type A receptor in guinea pig pancreatic membranes


Bioorg Med Chem Lett 14: 369-72 (2003)


Article DOI: 10.1016/j.bmcl.2003.11.001
BindingDB Entry DOI: 10.7270/Q2RJ4K1Z
More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM50016503
PNG
(Boc-Asp-D-Tyr(SO3Na)-Nle-Gly-Trp-Nle-Asp-Phe-NH2 |...)
Show SMILES CCCC[C@H](NC(=O)[C@@H](Cc1ccc(OS([O-])(=O)=O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C52H69N9O15S/c1-6-8-18-37(57-48(68)40(61-51(71)75-52(3,4)5)26-32-21-23-34(24-22-32)76-77(72,73)74)46(66)55-30-43(62)56-41(27-33-29-54-36-20-14-13-17-35(33)36)49(69)58-38(19-9-7-2)47(67)60-42(28-44(63)64)50(70)59-39(45(53)65)25-31-15-11-10-12-16-31/h10-17,20-24,29,37-42,54H,6-9,18-19,25-28,30H2,1-5H3,(H2,53,65)(H,55,66)(H,56,62)(H,57,68)(H,58,69)(H,59,70)(H,60,67)(H,61,71)(H,63,64)(H,72,73,74)/p-1/t37-,38-,39-,40+,41-,42-/m0/s1
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3n/an/an/an/an/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
The compound was tested for the inhibition of [3H]-Propionyl specific binding to Cholecystokinin 8 receptor of guinea pig brain


J Med Chem 32: 445-9 (1989)


Article DOI: 10.1021/jm00122a026
BindingDB Entry DOI: 10.7270/Q2S181GT
More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM50092384
PNG
(CHEMBL100538 | N-(1-Carbamoyl-2-phenyl-ethyl)-3-(2...)
Show SMILES CCCC[C@H](N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C35H44N6O9/c1-3-4-14-28(34(49)40-26(19-31(45)46)33(48)39-25(32(36)47)17-21-10-6-5-7-11-21)41(2)35(50)27(38-29(42)15-16-30(43)44)18-22-20-37-24-13-9-8-12-23(22)24/h5-13,20,25-28,37H,3-4,14-19H2,1-2H3,(H2,36,47)(H,38,42)(H,39,48)(H,40,49)(H,43,44)(H,45,46)/t25-,26-,27-,28-/m0/s1
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3.02n/an/an/an/an/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Affinity against Cholecystokinin type A receptor on guinea pig pancreatic membranes.


J Med Chem 43: 3614-23 (2000)


Article DOI: 10.1021/jm0000416
BindingDB Entry DOI: 10.7270/Q2RN373C
More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM50016506
PNG
(CHEMBL262687 | Sodium; (4-{2-(2-acetylamino-3-carb...)
Show SMILES CCCC[C@H](NC(=O)[C@H](Cc1ccc(CS([O-])(=O)=O)cc1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C50H65N9O13S/c1-4-6-16-37(56-48(67)40(54-30(3)60)24-32-19-21-33(22-20-32)29-73(70,71)72)46(65)53-28-43(61)55-41(25-34-27-52-36-18-12-11-15-35(34)36)49(68)57-38(17-7-5-2)47(66)59-42(26-44(62)63)50(69)58-39(45(51)64)23-31-13-9-8-10-14-31/h8-15,18-22,27,37-42,52H,4-7,16-17,23-26,28-29H2,1-3H3,(H2,51,64)(H,53,65)(H,54,60)(H,55,61)(H,56,67)(H,57,68)(H,58,69)(H,59,66)(H,62,63)(H,70,71,72)/p-1/t37-,38-,39-,40-,41-,42-/m0/s1
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3.20n/an/an/an/an/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
The compound was tested for the inhibition of [3H]-Propionyl specific binding to CCK-8 receptor of guinea pig pancreatic membrane


J Med Chem 32: 445-9 (1989)


Article DOI: 10.1021/jm00122a026
BindingDB Entry DOI: 10.7270/Q2S181GT
More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM50092402
PNG
(CHEMBL122872 | N-(1-Carbamoyl-2-phenyl-ethyl)-3-(2...)
Show SMILES CCCC[C@H](N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C34H44N6O7/c1-4-6-16-28(40(3)34(47)27(37-29(41)5-2)18-22-20-36-24-15-11-10-14-23(22)24)33(46)39-26(19-30(42)43)32(45)38-25(31(35)44)17-21-12-8-7-9-13-21/h7-15,20,25-28,36H,4-6,16-19H2,1-3H3,(H2,35,44)(H,37,41)(H,38,45)(H,39,46)(H,42,43)/t25-,26-,27-,28-/m0/s1
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4.35n/an/an/an/an/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Affinity against Cholecystokinin type A receptor on guinea pig pancreatic membranes.


J Med Chem 43: 3614-23 (2000)


Article DOI: 10.1021/jm0000416
BindingDB Entry DOI: 10.7270/Q2RN373C
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Mus musculus)
BDBM50073050
PNG
((S)-1-(3-Amino-pentanoyl)-2,3-dihydro-1H-indole-2-...)
Show SMILES CCCCNC(=O)[C@@H]1Cc2ccccc2N1C(=O)CC(N)CC
Show InChI InChI=1S/C18H27N3O2/c1-3-5-10-20-18(23)16-11-13-8-6-7-9-15(13)21(16)17(22)12-14(19)4-2/h6-9,14,16H,3-5,10-12,19H2,1-2H3,(H,20,23)/t14?,16-/m0/s1
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7n/an/an/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity of the compound in Cholecystokinin type A receptor binding assay (iv) in mice


J Med Chem 42: 181-201 (1999)


Article DOI: 10.1021/jm980521l
BindingDB Entry DOI: 10.7270/Q2T43S8P
More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM50046112
PNG
(3-(2-Amino-3-naphthalen-1-yl-propionylamino)-N-({[...)
Show SMILES CN([C@@H](Cc1c[nH]c2ccccc12)C(=O)OC(C)(C)C)C(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](N)Cc1cccc2ccccc12)c1ccccc1
Show InChI InChI=1S/C41H45N5O7/c1-41(2,3)53-40(52)34(22-28-24-43-32-20-11-10-19-30(28)32)46(4)39(51)36(26-14-6-5-7-15-26)45-38(50)33(23-35(47)48)44-37(49)31(42)21-27-17-12-16-25-13-8-9-18-29(25)27/h5-20,24,31,33-34,36,43H,21-23,42H2,1-4H3,(H,44,49)(H,45,50)(H,47,48)/t31-,33-,34-,36-/m0/s1
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8.30n/an/an/an/an/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Displacement of [3H]-pCCK-8 from cholecystokinin-A receptor in guinea pig pancreatic membrane


J Med Chem 36: 166-72 (1993)


Article DOI: 10.1021/jm00053a022
BindingDB Entry DOI: 10.7270/Q26M37FJ
More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM50092400
PNG
(3-(2-{[2-(2-Amino-propionylamino)-3-(1H-indol-3-yl...)
Show SMILES CCCC[C@H](N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](C)N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C34H45N7O7/c1-4-5-15-28(33(47)39-26(18-29(42)43)32(46)38-25(30(36)44)16-21-11-7-6-8-12-21)41(3)34(48)27(40-31(45)20(2)35)17-22-19-37-24-14-10-9-13-23(22)24/h6-14,19-20,25-28,37H,4-5,15-18,35H2,1-3H3,(H2,36,44)(H,38,46)(H,39,47)(H,40,45)(H,42,43)/t20-,25+,26+,27+,28+/m1/s1
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15n/an/an/an/an/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Affinity against Cholecystokinin type A receptor on guinea pig pancreatic membranes.


J Med Chem 43: 3614-23 (2000)


Article DOI: 10.1021/jm0000416
BindingDB Entry DOI: 10.7270/Q2RN373C
More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM50016505
PNG
(CHEMBL217767 | Sodium; (4-{2-(2-acetylamino-3-carb...)
Show SMILES CCCC[C@H](NC(=O)[C@@H](Cc1ccc(CS([O-])(=O)=O)cc1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C50H65N9O13S/c1-4-6-16-37(56-48(67)40(54-30(3)60)24-32-19-21-33(22-20-32)29-73(70,71)72)46(65)53-28-43(61)55-41(25-34-27-52-36-18-12-11-15-35(34)36)49(68)57-38(17-7-5-2)47(66)59-42(26-44(62)63)50(69)58-39(45(51)64)23-31-13-9-8-10-14-31/h8-15,18-22,27,37-42,52H,4-7,16-17,23-26,28-29H2,1-3H3,(H2,51,64)(H,53,65)(H,54,60)(H,55,61)(H,56,67)(H,57,68)(H,58,69)(H,59,66)(H,62,63)(H,70,71,72)/p-1/t37-,38-,39-,40+,41-,42-/m0/s1
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16n/an/an/an/an/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
The compound was tested for the inhibition of [3H]-Propionyl specific binding to Cholecystokinin 8 receptor of guinea pig pancreatic membrane


J Med Chem 32: 445-9 (1989)


Article DOI: 10.1021/jm00122a026
BindingDB Entry DOI: 10.7270/Q2S181GT
More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM50092394
PNG
((S)-3-((S)-2-{[(S)-2-(2-Amino-acetylamino)-3-(S)-1...)
Show SMILES CCCC[C@H](N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C33H43N7O7/c1-3-4-14-27(40(2)33(47)26(37-28(41)18-34)16-21-19-36-23-13-9-8-12-22(21)23)32(46)39-25(17-29(42)43)31(45)38-24(30(35)44)15-20-10-6-5-7-11-20/h5-13,19,24-27,36H,3-4,14-18,34H2,1-2H3,(H2,35,44)(H,37,41)(H,38,45)(H,39,46)(H,42,43)/t24-,25-,26-,27-/m0/s1
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18n/an/an/an/an/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Affinity against Cholecystokinin type A receptor on guinea pig pancreatic membranes.


J Med Chem 43: 3614-23 (2000)


Article DOI: 10.1021/jm0000416
BindingDB Entry DOI: 10.7270/Q2RN373C
More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM50016505
PNG
(CHEMBL217767 | Sodium; (4-{2-(2-acetylamino-3-carb...)
Show SMILES CCCC[C@H](NC(=O)[C@@H](Cc1ccc(CS([O-])(=O)=O)cc1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C50H65N9O13S/c1-4-6-16-37(56-48(67)40(54-30(3)60)24-32-19-21-33(22-20-32)29-73(70,71)72)46(65)53-28-43(61)55-41(25-34-27-52-36-18-12-11-15-35(34)36)49(68)57-38(17-7-5-2)47(66)59-42(26-44(62)63)50(69)58-39(45(51)64)23-31-13-9-8-10-14-31/h8-15,18-22,27,37-42,52H,4-7,16-17,23-26,28-29H2,1-3H3,(H2,51,64)(H,53,65)(H,54,60)(H,55,61)(H,56,67)(H,57,68)(H,58,69)(H,59,66)(H,62,63)(H,70,71,72)/p-1/t37-,38-,39-,40+,41-,42-/m0/s1
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19n/an/an/an/an/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
The compound was tested for the inhibition of [3H]-Propionyl specific binding to Cholecystokinin 8 receptor of guinea pig brain


J Med Chem 32: 445-9 (1989)


Article DOI: 10.1021/jm00122a026
BindingDB Entry DOI: 10.7270/Q2S181GT
More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM50092390
PNG
(3-(2-{[2-(2-Amino-propionylamino)-3-(1H-indol-3-yl...)
Show SMILES CCCC[C@H](N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C34H45N7O7/c1-4-5-15-28(33(47)39-26(18-29(42)43)32(46)38-25(30(36)44)16-21-11-7-6-8-12-21)41(3)34(48)27(40-31(45)20(2)35)17-22-19-37-24-14-10-9-13-23(22)24/h6-14,19-20,25-28,37H,4-5,15-18,35H2,1-3H3,(H2,36,44)(H,38,46)(H,39,47)(H,40,45)(H,42,43)/t20-,25-,26-,27-,28-/m0/s1
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20n/an/an/an/an/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Affinity against Cholecystokinin type A receptor on guinea pig pancreatic membranes.


J Med Chem 43: 3614-23 (2000)


Article DOI: 10.1021/jm0000416
BindingDB Entry DOI: 10.7270/Q2RN373C
More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM50016503
PNG
(Boc-Asp-D-Tyr(SO3Na)-Nle-Gly-Trp-Nle-Asp-Phe-NH2 |...)
Show SMILES CCCC[C@H](NC(=O)[C@@H](Cc1ccc(OS([O-])(=O)=O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C52H69N9O15S/c1-6-8-18-37(57-48(68)40(61-51(71)75-52(3,4)5)26-32-21-23-34(24-22-32)76-77(72,73)74)46(66)55-30-43(62)56-41(27-33-29-54-36-20-14-13-17-35(33)36)49(69)58-38(19-9-7-2)47(67)60-42(28-44(63)64)50(70)59-39(45(53)65)25-31-15-11-10-12-16-31/h10-17,20-24,29,37-42,54H,6-9,18-19,25-28,30H2,1-5H3,(H2,53,65)(H,55,66)(H,56,62)(H,57,68)(H,58,69)(H,59,70)(H,60,67)(H,61,71)(H,63,64)(H,72,73,74)/p-1/t37-,38-,39-,40+,41-,42-/m0/s1
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33n/an/an/an/an/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
The compound was tested for the inhibition of [3H]-Propionyl specific binding to Cholecystokinin 8 receptor of guinea pig pancreatic membrane


J Med Chem 32: 445-9 (1989)


Article DOI: 10.1021/jm00122a026
BindingDB Entry DOI: 10.7270/Q2S181GT
More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM50281664
PNG
(CHEMBL262894 | p-Tyr(SO3Na)-gNle-mGly-Trp-(N-Me)Nl...)
Show SMILES CCCC[C@H](NC(=O)[C@@H](N)Cc1ccc(OS([O-])(=O)=O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C47H61N9O13S/c1-3-5-15-35(53-43(61)33(48)22-29-18-20-31(21-19-29)69-70(66,67)68)44(62)51-27-40(57)52-38(24-30-26-50-34-17-11-10-14-32(30)34)46(64)54-36(16-6-4-2)45(63)56-39(25-41(58)59)47(65)55-37(42(49)60)23-28-12-8-7-9-13-28/h7-14,17-21,26,33,35-39,50H,3-6,15-16,22-25,27,48H2,1-2H3,(H2,49,60)(H,51,62)(H,52,57)(H,53,61)(H,54,64)(H,55,65)(H,56,63)(H,58,59)(H,66,67,68)/p-1/t33-,35-,36-,37-,38-,39-/m0/s1
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62n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested for the inhibition of [3H]-pCCK-8 binding to Cholecystokinin type A receptor in pancreatic membranes of guinea-pig


Bioorg Med Chem Lett 3: 847-850 (1993)


Article DOI: 10.1016/S0960-894X(00)80678-2
BindingDB Entry DOI: 10.7270/Q2P26Z28
More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM50477904
PNG
(CHEMBL401098)
Show SMILES COc1ccc(CCNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)cc1
Show InChI InChI=1S/C42H47N5O8/c1-42(2,3)55-41(53)47-35(23-30-25-44-33-12-8-7-11-32(30)33)40(52)45-34(22-27-13-16-28-9-5-6-10-29(28)21-27)39(51)46-36(24-37(48)49)38(50)43-20-19-26-14-17-31(54-4)18-15-26/h5-18,21,25,34-36,44H,19-20,22-24H2,1-4H3,(H,43,50)(H,45,52)(H,46,51)(H,47,53)(H,48,49)/t34-,35-,36-/m0/s1
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63n/an/an/an/an/an/an/an/a



James Black Foundation

Curated by ChEMBL


Assay Description
Displacement of [125I]BH-CCK-8S from CC1 receptor expressed in guinea pig pancreatic cells


J Med Chem 51: 565-73 (2008)

More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM50045802
PNG
(CHEMBL99252 | {[2-(Adamantan-2-yloxycarbonylamino)...)
Show SMILES CC(Cc1ccc2ccccc2c1)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccccc1)CC(O)=O
Show InChI InChI=1S/C35H40N2O5/c1-35(21-24-11-12-27-9-5-6-10-28(27)16-24,33(40)37(22-31(38)39)14-13-23-7-3-2-4-8-23)36-34(41)42-32-29-17-25-15-26(19-29)20-30(32)18-25/h2-12,16,25-26,29-30,32H,13-15,17-22H2,1H3,(H,36,41)(H,38,39)/t25-,26+,29-,30+,32?,35?
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70n/an/an/an/an/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Tested for inhibition of [3H]-pCCK-8 specific binding to cholecystokinin type A receptor in guinea pig pancreatic membranes


J Med Chem 36: 2868-77 (1993)


Article DOI: 10.1021/jm00072a005
BindingDB Entry DOI: 10.7270/Q2MG7NK5
More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM50016504
PNG
((S)-3-(2-{[(S)-2-(2-{2-[2-tert-Butoxycarbonylamino...)
Show SMILES CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS([O-])(=O)=O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C52H69N9O15S/c1-6-8-18-37(57-48(68)40(61-51(71)75-52(3,4)5)26-32-21-23-34(24-22-32)76-77(72,73)74)46(66)55-30-43(62)56-41(27-33-29-54-36-20-14-13-17-35(33)36)49(69)58-38(19-9-7-2)47(67)60-42(28-44(63)64)50(70)59-39(45(53)65)25-31-15-11-10-12-16-31/h10-17,20-24,29,37-42,54H,6-9,18-19,25-28,30H2,1-5H3,(H2,53,65)(H,55,66)(H,56,62)(H,57,68)(H,58,69)(H,59,70)(H,60,67)(H,61,71)(H,63,64)(H,72,73,74)/p-1/t37-,38-,39-,40-,41-,42-/m0/s1
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78n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested for the inhibition of [3H]-pCCK-8 binding to Cholecystokinin type A receptor in pancreatic membranes of guinea-pig


Bioorg Med Chem Lett 3: 847-850 (1993)


Article DOI: 10.1016/S0960-894X(00)80678-2
BindingDB Entry DOI: 10.7270/Q2P26Z28
More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM50092393
PNG
(3-(2-{[2-(2-{2-[2-tert-Butoxycarbonylamino-3-(4-su...)
Show SMILES CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(O)(=O)=O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@@H](CCCC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C53H71N9O15S/c1-7-9-19-38(58-48(68)40(61-52(72)76-53(3,4)5)27-33-22-24-35(25-23-33)77-78(73,74)75)47(67)56-31-44(63)57-42(28-34-30-55-37-20-15-14-18-36(34)37)51(71)62(6)43(21-10-8-2)50(70)60-41(29-45(64)65)49(69)59-39(46(54)66)26-32-16-12-11-13-17-32/h11-18,20,22-25,30,38-43,55H,7-10,19,21,26-29,31H2,1-6H3,(H2,54,66)(H,56,67)(H,57,63)(H,58,68)(H,59,69)(H,60,70)(H,61,72)(H,64,65)(H,73,74,75)/t38-,39-,40-,41-,42-,43-/m0/s1
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96n/an/an/an/an/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Affinity against Cholecystokinin type A receptor on guinea pig pancreatic membranes.


J Med Chem 43: 3614-23 (2000)


Article DOI: 10.1021/jm0000416
BindingDB Entry DOI: 10.7270/Q2RN373C
More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM50228603
PNG
(CHEMBL3350278)
Show SMILES CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(O)=O)C(N)=O
Show InChI InChI=1/C33H42N6O9/c1-33(2,3)48-32(46)39-26(16-21-18-36-23-13-8-7-12-22(21)23)30(44)37-24(29(43)38-25(28(34)42)17-27(40)41)14-9-15-35-31(45)47-19-20-10-5-4-6-11-20/h4-8,10-13,18,24-26,36H,9,14-17,19H2,1-3H3,(H2,34,42)(H,35,45)(H,37,44)(H,38,43)(H,39,46)(H,40,41)/t24-,25-,26-/s2
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200n/an/an/an/an/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Apparent affinity to inhibit binding of [3H]pCCK-8 to Cholecystokinin type A receptor of guinea pig pancreatic membranes


J Med Chem 33: 3199-204 (1991)


Article DOI: 10.1021/jm00174a016
BindingDB Entry DOI: 10.7270/Q2XP73WF
More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM50228604
PNG
(CHEMBL3350720)
Show SMILES CCCC[C@H](NC(=O)[C@H](Cc1ccc(cc1)S(O)(=O)=O)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(O)=O)C(N)=O
Show InChI InChI=1/C50H65N9O15S/c1-5-6-16-36(56-46(66)39(59-49(69)74-50(2,3)4)24-30-19-21-33(22-20-30)75(70,71)72)44(64)54-28-41(60)55-40(25-32-27-53-35-17-11-10-15-34(32)35)47(67)57-37(45(65)58-38(43(51)63)26-42(61)62)18-12-23-52-48(68)73-29-31-13-8-7-9-14-31/h7-11,13-15,17,19-22,27,36-40,53H,5-6,12,16,18,23-26,28-29H2,1-4H3,(H2,51,63)(H,52,68)(H,54,64)(H,55,60)(H,56,66)(H,57,67)(H,58,65)(H,59,69)(H,61,62)(H,70,71,72)/t36-,37-,38-,39-,40-/s2
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230n/an/an/an/an/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Apparent affinity to inhibit binding of [3H]pCCK-8 to Cholecystokinin type A receptor of guinea pig pancreatic membranes


J Med Chem 33: 3199-204 (1991)


Article DOI: 10.1021/jm00174a016
BindingDB Entry DOI: 10.7270/Q2XP73WF
More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM50056455
PNG
(CHEMBL348344 | N-(1-Carbamoyl-2-phenyl-ethyl)-3-{[...)
Show SMILES C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCSSCC[C@@H](NC1=O)C(=O)NC(CC(O)=O)C(=O)NC(Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C34H42N6O7S2/c1-34(19-22-20-36-24-12-6-5-11-23(22)24)33(47)39-25(14-16-49-48-15-8-7-13-28(41)40-34)31(45)38-27(18-29(42)43)32(46)37-26(30(35)44)17-21-9-3-2-4-10-21/h2-6,9-12,20,25-27,36H,7-8,13-19H2,1H3,(H2,35,44)(H,37,46)(H,38,45)(H,39,47)(H,40,41)(H,42,43)/t25-,26?,27?,34-/m1/s1
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271n/an/an/an/an/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Inhibition of [3H]pCCK-8 binding to Cholecystokinin type A receptor of Guinea pig pancreatic membranes


J Med Chem 40: 647-58 (1997)


Article DOI: 10.1021/jm9603072
BindingDB Entry DOI: 10.7270/Q2PG1SDX
More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM50470639
PNG
(CHEMBL433656)
Show SMILES OC(=O)c1cc(NC(=O)[C@@H](Cc2cccc(F)c2)NC(=O)C2C(C3c4ccccc4C2c2ccccc32)C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(c1)C(O)=O
Show InChI InChI=1S/C46H44FN3O7/c47-30-7-5-6-24(15-30)16-36(41(51)49-31-18-28(44(54)55)17-29(19-31)45(56)57)50-43(53)40-38-34-10-3-1-8-32(34)37(33-9-2-4-11-35(33)38)39(40)42(52)48-23-46-20-25-12-26(21-46)14-27(13-25)22-46/h1-11,15,17-19,25-27,36-40H,12-14,16,20-23H2,(H,48,52)(H,49,51)(H,50,53)(H,54,55)(H,56,57)/t25?,26?,27?,36-,37?,38?,39?,40?,46?/m1/s1
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302n/an/an/an/an/an/an/an/a



James Black Foundation

Curated by ChEMBL


Assay Description
Competition with 20 pM [125I]BH-CCK-8S at Cholecystokinin type A receptor binding sites on guinea pig pancreatic cells


J Med Chem 38: 4294-302 (1995)

More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM50470630
PNG
(CHEMBL436187)
Show SMILES O=C(Nc1cc(cc(c1)-n1cnnn1)-n1cnnn1)[C@H](Cc1ccccc1)NC(=O)C1C(C2c3ccccc3C1c1ccccc21)C(=O)NCC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C46H45N11O3/c58-43(50-31-18-32(56-25-48-52-54-56)20-33(19-31)57-26-49-53-55-57)38(17-27-8-2-1-3-9-27)51-45(60)42-40-36-12-6-4-10-34(36)39(35-11-5-7-13-37(35)40)41(42)44(59)47-24-46-21-28-14-29(22-46)16-30(15-28)23-46/h1-13,18-20,25-26,28-30,38-42H,14-17,21-24H2,(H,47,59)(H,50,58)(H,51,60)/t28?,29?,30?,38-,39?,40?,41?,42?,46?/m0/s1
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302n/an/an/an/an/an/an/an/a



James Black Foundation

Curated by ChEMBL


Assay Description
Competition with 20 pM [125I]BH-CCK-8S at Cholecystokinin type A receptor binding sites on guinea pig pancreatic cells


J Med Chem 38: 4294-302 (1995)

More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM50228605
PNG
(CHEMBL3350665)
Show SMILES CCCC[C@H](NC(=O)[C@H](Cc1ccc(cc1)S(O)(=O)=O)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1/C59H74N10O16S/c1-5-6-21-43(65-54(76)46(69-58(80)85-59(2,3)4)30-37-24-26-40(27-25-37)86(81,82)83)52(74)63-34-49(70)64-47(31-39-33-62-42-22-14-13-20-41(39)42)55(77)66-44(23-15-28-61-57(79)84-35-38-18-11-8-12-19-38)53(75)68-48(32-50(71)72)56(78)67-45(51(60)73)29-36-16-9-7-10-17-36/h7-14,16-20,22,24-27,33,43-48,62H,5-6,15,21,23,28-32,34-35H2,1-4H3,(H2,60,73)(H,61,79)(H,63,74)(H,64,70)(H,65,76)(H,66,77)(H,67,78)(H,68,75)(H,69,80)(H,71,72)(H,81,82,83)/t43-,44-,45-,46-,47-,48-/s2
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310n/an/an/an/an/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Apparent affinity to inhibit binding of [3H]-pCCK-8 to Cholecystokinin type B receptor of guinea pig brain membranes


J Med Chem 33: 3199-204 (1991)


Article DOI: 10.1021/jm00174a016
BindingDB Entry DOI: 10.7270/Q2XP73WF
More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM81962
PNG
(S-L-365,260)
Show SMILES CN1c2ccccc2C(=N[C@@H](NC(=O)Nc2cccc(C)c2)C1=O)c1ccccc1
Show InChI InChI=1/C24H22N4O2/c1-16-9-8-12-18(15-16)25-24(30)27-22-23(29)28(2)20-14-7-6-13-19(20)21(26-22)17-10-4-3-5-11-17/h3-15,22H,1-2H3,(H2,25,27,30)/t22-/s2
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316n/an/an/an/an/an/an/an/a



James Black Foundation

Curated by ChEMBL


Assay Description
Displacement of [125I]BH-CCK-8S from CC1 receptor expressed in guinea pig pancreatic cells


J Med Chem 51: 565-73 (2008)

More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM50477908
PNG
(CHEMBL398312)
Show SMILES CN1c2ccccc2C(=N[C@@H](NC(=O)Nc2cccc(c2)-c2nnn[nH]2)C1=O)c1ccccc1
Show InChI InChI=1S/C24H20N8O2/c1-32-19-13-6-5-12-18(19)20(15-8-3-2-4-9-15)26-22(23(32)33)27-24(34)25-17-11-7-10-16(14-17)21-28-30-31-29-21/h2-14,22H,1H3,(H2,25,27,34)(H,28,29,30,31)/t22-/m0/s1
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316n/an/an/an/an/an/an/an/a



James Black Foundation

Curated by ChEMBL


Assay Description
Displacement of [125I]BH-CCK-8S from CC1 receptor expressed in guinea pig pancreatic cells


J Med Chem 51: 565-73 (2008)

More data for this
Ligand-Target Pair
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