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Compile Data Set for Download or QSAR

Found 6611 hits Enz. Inhib. hit(s) with Target = 'Cholecystokinin receptor'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
CCKBR


(RAT)
BDBM50056102
PNG
((R)-1-(1-(3,3-dimethyl-2-oxobutyl)-2-oxo-5-(pyridi...)
Show SMILES CNc1cccc(NC(=O)N[C@@H]2N=C(c3ccccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1
Show InChI InChI=1S/C28H30N6O3/c1-28(2,3)23(35)17-34-22-14-6-5-12-20(22)24(21-13-7-8-15-30-21)32-25(26(34)36)33-27(37)31-19-11-9-10-18(16-19)29-4/h5-16,25,29H,17H2,1-4H3,(H2,31,33,37)/t25-/m0/s1
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n/an/an/a 0.0794n/an/an/an/an/a



James Black Foundation

Curated by ChEMBL


Assay Description
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach


J Med Chem 49: 2253-61 (2006)


Article DOI: 10.1021/jm051219x
BindingDB Entry DOI: 10.7270/Q28K7B8B
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50285624
PNG
((R)-3-[(R)-2-(Adamantan-2-yloxycarbonylamino)-3-(1...)
Show SMILES C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(O)=O)Cc1ccc(N)cc1
Show InChI InChI=1S/C33H40N4O5/c1-33(17-24-18-35-28-5-3-2-4-27(24)28,31(40)36-26(16-29(38)39)15-19-6-8-25(34)9-7-19)37-32(41)42-30-22-11-20-10-21(13-22)14-23(30)12-20/h2-9,18,20-23,26,30,35H,10-17,34H2,1H3,(H,36,40)(H,37,41)(H,38,39)/t20?,21?,22?,23?,26-,30?,33-/m1/s1
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n/an/an/a 0.110n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
The equilibrium binding constant to guinea pig cerebral cortex membranes was measured


Bioorg Med Chem Lett 5: 2501-2506 (1995)


Article DOI: 10.1016/0960-894X(95)00435-V
BindingDB Entry DOI: 10.7270/Q2DZ08SM
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50285623
PNG
((R)-3-[(R)-2-(Adamantan-2-yloxycarbonylamino)-3-(1...)
Show SMILES C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(O)=O)Cc1ccc(N)c(I)c1
Show InChI InChI=1S/C33H39IN4O5/c1-33(16-23-17-36-28-5-3-2-4-25(23)28,38-32(42)43-30-21-9-19-8-20(11-21)12-22(30)10-19)31(41)37-24(15-29(39)40)13-18-6-7-27(35)26(34)14-18/h2-7,14,17,19-22,24,30,36H,8-13,15-16,35H2,1H3,(H,37,41)(H,38,42)(H,39,40)/t19?,20?,21?,22?,24-,30?,33-/m1/s1
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n/an/an/a 0.25n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
The equilibrium binding constant to guinea pig cerebral cortex membranes was measured


Bioorg Med Chem Lett 5: 2501-2506 (1995)


Article DOI: 10.1016/0960-894X(95)00435-V
BindingDB Entry DOI: 10.7270/Q2DZ08SM
More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50410552
PNG
(CHEMBL198933)
Show SMILES OC(=O)c1cccc(NC(=O)c2[nH]c(nc2COC23CC4CC(CC(C4)C2)C3)C23CCC(CC2)CC3)c1
Show InChI InChI=1S/C30H37N3O4/c34-26(31-23-3-1-2-22(13-23)27(35)36)25-24(32-28(33-25)29-7-4-18(5-8-29)6-9-29)17-37-30-14-19-10-20(15-30)12-21(11-19)16-30/h1-3,13,18-21H,4-12,14-17H2,(H,31,34)(H,32,33)(H,35,36)
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n/an/an/a 0.708n/an/an/an/an/a



James Black Foundation

Curated by ChEMBL


Assay Description
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach


J Med Chem 48: 6803-12 (2005)


Article DOI: 10.1021/jm0490686
BindingDB Entry DOI: 10.7270/Q2PV6MM7
More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50410544
PNG
(CHEMBL390519)
Show SMILES OC(=O)c1cccc(NC(=O)c2[nH]c(nc2COC23CC4CC(CC(C4)C2)C3)C2CCCCC2)c1
Show InChI InChI=1S/C28H35N3O4/c32-26(29-22-8-4-7-21(12-22)27(33)34)24-23(30-25(31-24)20-5-2-1-3-6-20)16-35-28-13-17-9-18(14-28)11-19(10-17)15-28/h4,7-8,12,17-20H,1-3,5-6,9-11,13-16H2,(H,29,32)(H,30,31)(H,33,34)
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n/an/an/a 0.871n/an/an/an/an/a



James Black Foundation

Curated by ChEMBL


Assay Description
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach


J Med Chem 48: 6803-12 (2005)


Article DOI: 10.1021/jm0490686
BindingDB Entry DOI: 10.7270/Q2PV6MM7
More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50410564
PNG
(CHEMBL425574)
Show SMILES Cc1ccc(NC(=O)c2[nH]c(nc2CCC23CC4CC(CC(C4)C2)C3)C2(C)CCCCC2)cc1C(O)=O
Show InChI InChI=1S/C31H41N3O3/c1-19-6-7-23(15-24(19)28(36)37)32-27(35)26-25(33-29(34-26)30(2)9-4-3-5-10-30)8-11-31-16-20-12-21(17-31)14-22(13-20)18-31/h6-7,15,20-22H,3-5,8-14,16-18H2,1-2H3,(H,32,35)(H,33,34)(H,36,37)
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n/an/an/a 0.891n/an/an/an/an/a



James Black Foundation

Curated by ChEMBL


Assay Description
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach


J Med Chem 48: 6803-12 (2005)


Article DOI: 10.1021/jm0490686
BindingDB Entry DOI: 10.7270/Q2PV6MM7
More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50410847
PNG
(CHEMBL205455)
Show SMILES CC(C)(C)C(=O)CN1c2ccccc2C(=NN(CC(=O)Nc2cccc(c2)C(O)=O)C1=O)C1CCCCC1
Show InChI InChI=1S/C29H34N4O5/c1-29(2,3)24(34)17-32-23-15-8-7-14-22(23)26(19-10-5-4-6-11-19)31-33(28(32)38)18-25(35)30-21-13-9-12-20(16-21)27(36)37/h7-9,12-16,19H,4-6,10-11,17-18H2,1-3H3,(H,30,35)(H,36,37)
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n/an/an/a 0.977n/an/an/an/an/a



James Black Foundation

Curated by ChEMBL


Assay Description
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach


J Med Chem 49: 2253-61 (2006)


Article DOI: 10.1021/jm051219x
BindingDB Entry DOI: 10.7270/Q28K7B8B
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM21147
PNG
((3S)-3-[(2S)-2-[(2S)-2-{2-[(2S)-2-[(2S)-2-[(3S)-3-...)
Show SMILES CSCC[C@H](NC(=O)[C@H](Cc1ccc(OS(O)(=O)=O)cc1)NC(=O)[C@@H](N)CC(O)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C49H62N10O16S3/c1-76-18-16-34(55-47(69)37(58-44(66)32(50)23-41(61)62)21-28-12-14-30(15-13-28)75-78(72,73)74)45(67)53-26-40(60)54-38(22-29-25-52-33-11-7-6-10-31(29)33)48(70)56-35(17-19-77-2)46(68)59-39(24-42(63)64)49(71)57-36(43(51)65)20-27-8-4-3-5-9-27/h3-15,25,32,34-39,52H,16-24,26,50H2,1-2H3,(H2,51,65)(H,53,67)(H,54,60)(H,55,69)(H,56,70)(H,57,71)(H,58,66)(H,59,68)(H,61,62)(H,63,64)(H,72,73,74)/t32-,34-,35-,36-,37-,38-,39-/m0/s1
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n/an/an/a 1.30 27n/an/an/an/a



University of Arizona Tucson



Assay Description
Log IC50 values for each test compound were determined from nonlinear regression analysis of data collected from two independent experiments performe...


J Med Chem 49: 2868-75 (2006)


Article DOI: 10.1021/jm050921q
BindingDB Entry DOI: 10.7270/Q24Q7S99
More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50410842
PNG
(CHEMBL204154)
Show SMILES CNc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1
Show InChI InChI=1S/C29H37N5O3/c1-29(2,3)25(35)18-33-24-16-9-8-15-23(24)27(20-11-6-5-7-12-20)32-34(28(33)37)19-26(36)31-22-14-10-13-21(17-22)30-4/h8-10,13-17,20,30H,5-7,11-12,18-19H2,1-4H3,(H,31,36)
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n/an/an/a 1.32n/an/an/an/an/a



James Black Foundation

Curated by ChEMBL


Assay Description
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach


J Med Chem 49: 2253-61 (2006)


Article DOI: 10.1021/jm051219x
BindingDB Entry DOI: 10.7270/Q28K7B8B
More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50026690
PNG
(2-[2-(2-{2-[2-{2-[2-(2-Amino-3-phenyl-propionylami...)
Show SMILES CSCC[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](C)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C97H126N20O32S/c1-49(2)39-68(114-95(147)71(43-54-46-101-60-18-11-9-16-57(54)60)116-97(149)73-19-12-37-117(73)75(120)48-103-85(137)58(98)24-30-76(121)122)93(145)110-65(29-35-81(131)132)91(143)109-64(28-34-80(129)130)90(142)108-63(27-33-79(127)128)89(141)107-62(26-32-78(125)126)88(140)106-61(25-31-77(123)124)87(139)104-50(3)84(136)113-69(41-52-20-22-55(118)23-21-52)86(138)102-47-74(119)105-70(42-53-45-100-59-17-10-8-15-56(53)59)94(146)111-66(36-38-150-4)92(144)115-72(44-82(133)134)96(148)112-67(83(99)135)40-51-13-6-5-7-14-51/h5-11,13-18,20-23,45-46,49-50,58,61-73,100-101,118H,12,19,24-44,47-48,98H2,1-4H3,(H2,99,135)(H,102,138)(H,103,137)(H,104,139)(H,105,119)(H,106,140)(H,107,141)(H,108,142)(H,109,143)(H,110,145)(H,111,146)(H,112,148)(H,113,136)(H,114,147)(H,115,144)(H,116,149)(H,121,122)(H,123,124)(H,125,126)(H,127,128)(H,129,130)(H,131,132)(H,133,134)/t50-,58+,61-,62-,63-,64+,65+,66-,67-,68+,69-,70-,71+,72-,73+/m1/s1
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n/an/an/a 1.40n/an/an/an/an/a



National Cancer Institute-Frederick

Curated by ChEMBL


Assay Description
Tested in vitro by the gastrin binding assay for the competitive binding with iodinated gastrin for the gastrin receptors in AR42J cells


J Med Chem 37: 3812-8 (1994)


Article DOI: 10.1021/jm00048a016
BindingDB Entry DOI: 10.7270/Q2TM7BRX
More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50410555
PNG
(CHEMBL373050)
Show SMILES CC1(CCCCC1)c1nc(CCC23CC4CC(CC(C4)C2)C3)c([nH]1)C(=O)Nc1cccc(c1)C(O)=O
Show InChI InChI=1S/C30H39N3O3/c1-29(9-3-2-4-10-29)28-32-24(8-11-30-16-19-12-20(17-30)14-21(13-19)18-30)25(33-28)26(34)31-23-7-5-6-22(15-23)27(35)36/h5-7,15,19-21H,2-4,8-14,16-18H2,1H3,(H,31,34)(H,32,33)(H,35,36)
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n/an/an/a 1.62n/an/an/an/an/a



James Black Foundation

Curated by ChEMBL


Assay Description
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach


J Med Chem 48: 6803-12 (2005)


Article DOI: 10.1021/jm0490686
BindingDB Entry DOI: 10.7270/Q2PV6MM7
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM21147
PNG
((3S)-3-[(2S)-2-[(2S)-2-{2-[(2S)-2-[(2S)-2-[(3S)-3-...)
Show SMILES CSCC[C@H](NC(=O)[C@H](Cc1ccc(OS(O)(=O)=O)cc1)NC(=O)[C@@H](N)CC(O)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C49H62N10O16S3/c1-76-18-16-34(55-47(69)37(58-44(66)32(50)23-41(61)62)21-28-12-14-30(15-13-28)75-78(72,73)74)45(67)53-26-40(60)54-38(22-29-25-52-33-11-7-6-10-31(29)33)48(70)56-35(17-19-77-2)46(68)59-39(24-42(63)64)49(71)57-36(43(51)65)20-27-8-4-3-5-9-27/h3-15,25,32,34-39,52H,16-24,26,50H2,1-2H3,(H2,51,65)(H,53,67)(H,54,60)(H,55,69)(H,56,70)(H,57,71)(H,58,66)(H,59,68)(H,61,62)(H,63,64)(H,72,73,74)/t32-,34-,35-,36-,37-,38-,39-/m0/s1
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n/an/an/a 1.90 28n/an/an/an/a



University of Arizona Tucson



Assay Description
Log IC50 values for each test compound were determined from nonlinear regression analysis of data collected from two independent experiments performe...


J Med Chem 49: 2868-75 (2006)


Article DOI: 10.1021/jm050921q
BindingDB Entry DOI: 10.7270/Q24Q7S99
More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50410558
PNG
(CHEMBL199091)
Show SMILES OC(=O)c1cccc(NC(=O)c2[nH]c(nc2CCC23CC4CC(CC(C4)C2)C3)C23CCC(CC2)CC3)c1
Show InChI InChI=1S/C31H39N3O3/c35-27(32-24-3-1-2-23(15-24)28(36)37)26-25(33-29(34-26)31-9-4-19(5-10-31)6-11-31)7-8-30-16-20-12-21(17-30)14-22(13-20)18-30/h1-3,15,19-22H,4-14,16-18H2,(H,32,35)(H,33,34)(H,36,37)
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n/an/an/a 2.45n/an/an/an/an/a



James Black Foundation

Curated by ChEMBL


Assay Description
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach


J Med Chem 48: 6803-12 (2005)


Article DOI: 10.1021/jm0490686
BindingDB Entry DOI: 10.7270/Q2PV6MM7
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50026690
PNG
(2-[2-(2-{2-[2-{2-[2-(2-Amino-3-phenyl-propionylami...)
Show SMILES CSCC[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](C)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C97H126N20O32S/c1-49(2)39-68(114-95(147)71(43-54-46-101-60-18-11-9-16-57(54)60)116-97(149)73-19-12-37-117(73)75(120)48-103-85(137)58(98)24-30-76(121)122)93(145)110-65(29-35-81(131)132)91(143)109-64(28-34-80(129)130)90(142)108-63(27-33-79(127)128)89(141)107-62(26-32-78(125)126)88(140)106-61(25-31-77(123)124)87(139)104-50(3)84(136)113-69(41-52-20-22-55(118)23-21-52)86(138)102-47-74(119)105-70(42-53-45-100-59-17-10-8-15-56(53)59)94(146)111-66(36-38-150-4)92(144)115-72(44-82(133)134)96(148)112-67(83(99)135)40-51-13-6-5-7-14-51/h5-11,13-18,20-23,45-46,49-50,58,61-73,100-101,118H,12,19,24-44,47-48,98H2,1-4H3,(H2,99,135)(H,102,138)(H,103,137)(H,104,139)(H,105,119)(H,106,140)(H,107,141)(H,108,142)(H,109,143)(H,110,145)(H,111,146)(H,112,148)(H,113,136)(H,114,147)(H,115,144)(H,116,149)(H,121,122)(H,123,124)(H,125,126)(H,127,128)(H,129,130)(H,131,132)(H,133,134)/t50-,58+,61-,62-,63-,64+,65+,66-,67-,68+,69-,70-,71+,72-,73+/m1/s1
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n/an/an/a 3.20n/an/an/an/an/a



National Cancer Institute-Frederick

Curated by ChEMBL


Assay Description
Tested in vitro for gastrin binding to gastrin receptors from guinea pig gastric glands


J Med Chem 37: 3812-8 (1994)


Article DOI: 10.1021/jm00048a016
BindingDB Entry DOI: 10.7270/Q2TM7BRX
More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50411975
PNG
(CHEMBL407340)
Show SMILES CC(C)(C)C(=O)CN1c2ccccc2N(C2CCCCCC2)C(=O)N(CC(=O)Nc2cccc(c2)-c2nc(=O)o[nH]2)C1=O
Show InChI InChI=1S/C31H36N6O6/c1-31(2,3)25(38)18-35-23-15-8-9-16-24(23)37(22-13-6-4-5-7-14-22)30(42)36(29(35)41)19-26(39)32-21-12-10-11-20(17-21)27-33-28(40)43-34-27/h8-12,15-17,22H,4-7,13-14,18-19H2,1-3H3,(H,32,39)(H,33,34,40)
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n/an/an/a 3.24n/an/an/an/an/a



James Black Foundation

Curated by ChEMBL


Assay Description
Antagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretion


Bioorg Med Chem 16: 2974-83 (2008)


Article DOI: 10.1016/j.bmc.2007.12.047
BindingDB Entry DOI: 10.7270/Q2FT8N8D
More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50410551
PNG
(CHEMBL195007)
Show SMILES Cc1cc(C)c(-c2nc(CCC34CC5CC(CC(C5)C3)C4)c([nH]2)C(=O)Nc2ccc(C)c(c2)C(O)=O)c(C)c1
Show InChI InChI=1S/C33H39N3O3/c1-18-9-20(3)28(21(4)10-18)30-35-27(7-8-33-15-22-11-23(16-33)13-24(12-22)17-33)29(36-30)31(37)34-25-6-5-19(2)26(14-25)32(38)39/h5-6,9-10,14,22-24H,7-8,11-13,15-17H2,1-4H3,(H,34,37)(H,35,36)(H,38,39)
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n/an/an/a 3.31n/an/an/an/an/a



James Black Foundation

Curated by ChEMBL


Assay Description
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach


J Med Chem 48: 6803-12 (2005)


Article DOI: 10.1021/jm0490686
BindingDB Entry DOI: 10.7270/Q2PV6MM7
More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50411972
PNG
(CHEMBL258863)
Show SMILES CC(C)(C)C(=O)CN1c2ccccc2N(C2CCCCCC2)C(=O)N(CC(=O)Nc2cccc(SCC(O)=O)c2)C1=O
Show InChI InChI=1S/C31H38N4O6S/c1-31(2,3)26(36)18-33-24-15-8-9-16-25(24)35(22-12-6-4-5-7-13-22)30(41)34(29(33)40)19-27(37)32-21-11-10-14-23(17-21)42-20-28(38)39/h8-11,14-17,22H,4-7,12-13,18-20H2,1-3H3,(H,32,37)(H,38,39)
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n/an/an/a 4.47n/an/an/an/an/a



James Black Foundation

Curated by ChEMBL


Assay Description
Antagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretion


Bioorg Med Chem 16: 2974-83 (2008)


Article DOI: 10.1016/j.bmc.2007.12.047
BindingDB Entry DOI: 10.7270/Q2FT8N8D
More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50410557
PNG
(CHEMBL196133)
Show SMILES OC(=O)c1cccc(NC(=O)c2[nH]c(nc2CCC23CC4CC(CC(C4)C2)C3)C2CCCCC2)c1
Show InChI InChI=1S/C29H37N3O3/c33-27(30-23-8-4-7-22(14-23)28(34)35)25-24(31-26(32-25)21-5-2-1-3-6-21)9-10-29-15-18-11-19(16-29)13-20(12-18)17-29/h4,7-8,14,18-21H,1-3,5-6,9-13,15-17H2,(H,30,33)(H,31,32)(H,34,35)
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n/an/an/a 4.90n/an/an/an/an/a



James Black Foundation

Curated by ChEMBL


Assay Description
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach


J Med Chem 48: 6803-12 (2005)


Article DOI: 10.1021/jm0490686
BindingDB Entry DOI: 10.7270/Q2PV6MM7
More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50410568
PNG
(CHEMBL196517)
Show SMILES OC(=O)c1cccc(NC(=O)c2[nH]c(nc2CCC23CC4CC(CC(C4)C2)C3)C2CCCCCC2)c1
Show InChI InChI=1S/C30H39N3O3/c34-28(31-24-9-5-8-23(15-24)29(35)36)26-25(32-27(33-26)22-6-3-1-2-4-7-22)10-11-30-16-19-12-20(17-30)14-21(13-19)18-30/h5,8-9,15,19-22H,1-4,6-7,10-14,16-18H2,(H,31,34)(H,32,33)(H,35,36)
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n/an/an/a 5.37n/an/an/an/an/a



James Black Foundation

Curated by ChEMBL


Assay Description
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach


J Med Chem 48: 6803-12 (2005)


Article DOI: 10.1021/jm0490686
BindingDB Entry DOI: 10.7270/Q2PV6MM7
More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50410561
PNG
(CHEMBL426290)
Show SMILES OC(=O)c1cccc(NC(=O)c2[nH]c(nc2CCC23CC4CC(CC(C4)C2)C3)C2CCCC2)c1
Show InChI InChI=1S/C28H35N3O3/c32-26(29-22-7-3-6-21(13-22)27(33)34)24-23(30-25(31-24)20-4-1-2-5-20)8-9-28-14-17-10-18(15-28)12-19(11-17)16-28/h3,6-7,13,17-20H,1-2,4-5,8-12,14-16H2,(H,29,32)(H,30,31)(H,33,34)
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n/an/an/a 7.08n/an/an/an/an/a



James Black Foundation

Curated by ChEMBL


Assay Description
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach


J Med Chem 48: 6803-12 (2005)


Article DOI: 10.1021/jm0490686
BindingDB Entry DOI: 10.7270/Q2PV6MM7
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50285625
PNG
((R)-3-[(R)-2-(Adamantan-2-yloxycarbonylamino)-3-(1...)
Show SMILES C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(O)=O)Cc1ccc(N=[N+]=[N-])c(I)c1
Show InChI InChI=1S/C33H37IN6O5/c1-33(16-23-17-36-27-5-3-2-4-25(23)27,38-32(44)45-30-21-9-19-8-20(11-21)12-22(30)10-19)31(43)37-24(15-29(41)42)13-18-6-7-28(39-40-35)26(34)14-18/h2-7,14,17,19-22,24,30,36H,8-13,15-16H2,1H3,(H,37,43)(H,38,44)(H,41,42)/t19?,20?,21?,22?,24-,30?,33-/m1/s1
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n/an/an/a 8.10n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
The equilibrium binding constant to pig cerebral cortex membranes was measured


Bioorg Med Chem Lett 5: 2501-2506 (1995)


Article DOI: 10.1016/0960-894X(95)00435-V
BindingDB Entry DOI: 10.7270/Q2DZ08SM
More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50410560
PNG
(CHEMBL196745)
Show SMILES Cc1cc(C)c(-c2nc(CCC34CC5CC(CC(C5)C3)C4)c([nH]2)C(=O)Nc2cccc(c2)C(O)=O)c(C)c1
Show InChI InChI=1S/C32H37N3O3/c1-18-9-19(2)27(20(3)10-18)29-34-26(7-8-32-15-21-11-22(16-32)13-23(12-21)17-32)28(35-29)30(36)33-25-6-4-5-24(14-25)31(37)38/h4-6,9-10,14,21-23H,7-8,11-13,15-17H2,1-3H3,(H,33,36)(H,34,35)(H,37,38)
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n/an/an/a 8.71n/an/an/an/an/a



James Black Foundation

Curated by ChEMBL


Assay Description
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach


J Med Chem 48: 6803-12 (2005)


Article DOI: 10.1021/jm0490686
BindingDB Entry DOI: 10.7270/Q2PV6MM7
More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50410550
PNG
(CHEMBL370882)
Show SMILES Cc1ccc(-c2nc(CCC34CC5CC(CC(C5)C3)C4)c([nH]2)C(=O)Nc2cccc(c2)C(O)=O)c(C)c1
Show InChI InChI=1S/C31H35N3O3/c1-18-6-7-25(19(2)10-18)28-33-26(8-9-31-15-20-11-21(16-31)13-22(12-20)17-31)27(34-28)29(35)32-24-5-3-4-23(14-24)30(36)37/h3-7,10,14,20-22H,8-9,11-13,15-17H2,1-2H3,(H,32,35)(H,33,34)(H,36,37)
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n/an/an/a 10n/an/an/an/an/a



James Black Foundation

Curated by ChEMBL


Assay Description
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach


J Med Chem 48: 6803-12 (2005)


Article DOI: 10.1021/jm0490686
BindingDB Entry DOI: 10.7270/Q2PV6MM7
More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50410548
PNG
(CHEMBL197370)
Show SMILES CC(C)(C)c1nc(CCC23CC4CC(CC(C4)C2)C3)c([nH]1)C(=O)Nc1cccc(c1)C(O)=O
Show InChI InChI=1S/C27H35N3O3/c1-26(2,3)25-29-21(7-8-27-13-16-9-17(14-27)11-18(10-16)15-27)22(30-25)23(31)28-20-6-4-5-19(12-20)24(32)33/h4-6,12,16-18H,7-11,13-15H2,1-3H3,(H,28,31)(H,29,30)(H,32,33)
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n/an/an/a 11.0n/an/an/an/an/a



James Black Foundation

Curated by ChEMBL


Assay Description
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach


J Med Chem 48: 6803-12 (2005)


Article DOI: 10.1021/jm0490686
BindingDB Entry DOI: 10.7270/Q2PV6MM7
More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50411971
PNG
(CHEMBL264150)
Show SMILES CN(c1nnn[nH]1)c1cccc(NC(=O)CN2C(=O)N(CC(=O)C(C)(C)C)c3ccccc3N(C3CCCCC3)C2=O)c1
Show InChI InChI=1S/C30H37N9O4/c1-30(2,3)25(40)18-37-23-15-8-9-16-24(23)39(21-12-6-5-7-13-21)29(43)38(28(37)42)19-26(41)31-20-11-10-14-22(17-20)36(4)27-32-34-35-33-27/h8-11,14-17,21H,5-7,12-13,18-19H2,1-4H3,(H,31,41)(H,32,33,34,35)
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n/an/an/a 12.6n/an/an/an/an/a



James Black Foundation

Curated by ChEMBL


Assay Description
Antagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretion


Bioorg Med Chem 16: 2974-83 (2008)


Article DOI: 10.1016/j.bmc.2007.12.047
BindingDB Entry DOI: 10.7270/Q2FT8N8D
More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50410556
PNG
(CHEMBL197780)
Show SMILES Cc1cc(C)c(-c2nc(COC34CC5CC(CC(C5)C3)C4)c([nH]2)C(=O)Nc2cccc(c2)C(O)=O)c(C)c1
Show InChI InChI=1S/C31H35N3O4/c1-17-7-18(2)26(19(3)8-17)28-33-25(16-38-31-13-20-9-21(14-31)11-22(10-20)15-31)27(34-28)29(35)32-24-6-4-5-23(12-24)30(36)37/h4-8,12,20-22H,9-11,13-16H2,1-3H3,(H,32,35)(H,33,34)(H,36,37)
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n/an/an/a 13.5n/an/an/an/an/a



James Black Foundation

Curated by ChEMBL


Assay Description
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach


J Med Chem 48: 6803-12 (2005)


Article DOI: 10.1021/jm0490686
BindingDB Entry DOI: 10.7270/Q2PV6MM7
More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50410845
PNG
(CHEMBL205198)
Show SMILES CC(C)(C)C(=O)CN1c2ccccc2C(=NN(CC(=O)Nc2cccc(CO)c2)C1=O)C1CCCCC1
Show InChI InChI=1S/C29H36N4O4/c1-29(2,3)25(35)17-32-24-15-8-7-14-23(24)27(21-11-5-4-6-12-21)31-33(28(32)37)18-26(36)30-22-13-9-10-20(16-22)19-34/h7-10,13-16,21,34H,4-6,11-12,17-19H2,1-3H3,(H,30,36)
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n/an/an/a 17.0n/an/an/an/an/a



James Black Foundation

Curated by ChEMBL


Assay Description
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach


J Med Chem 49: 2253-61 (2006)


Article DOI: 10.1021/jm051219x
BindingDB Entry DOI: 10.7270/Q28K7B8B
More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50410838
PNG
(CHEMBL380193)
Show SMILES CC(C)(C)C(=O)CN1c2ccccc2C(=NN(CC(=O)Nc2cccc(c2)N2CCOCC2)C1=O)C1CCCCC1
Show InChI InChI=1S/C32H41N5O4/c1-32(2,3)28(38)21-36-27-15-8-7-14-26(27)30(23-10-5-4-6-11-23)34-37(31(36)40)22-29(39)33-24-12-9-13-25(20-24)35-16-18-41-19-17-35/h7-9,12-15,20,23H,4-6,10-11,16-19,21-22H2,1-3H3,(H,33,39)
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n/an/an/a 18.2n/an/an/an/an/a



James Black Foundation

Curated by ChEMBL


Assay Description
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach


J Med Chem 49: 2253-61 (2006)


Article DOI: 10.1021/jm051219x
BindingDB Entry DOI: 10.7270/Q28K7B8B
More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50411977
PNG
(CHEMBL260394)
Show SMILES CNc1cccc(NC(=O)CN2C(=O)N(CC(=O)C(C)(C)C)c3ccccc3N(C3CCCCC3)C2=O)c1
Show InChI InChI=1S/C29H37N5O4/c1-29(2,3)25(35)18-32-23-15-8-9-16-24(23)34(22-13-6-5-7-14-22)28(38)33(27(32)37)19-26(36)31-21-12-10-11-20(17-21)30-4/h8-12,15-17,22,30H,5-7,13-14,18-19H2,1-4H3,(H,31,36)
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n/an/an/a 19.5n/an/an/an/an/a



James Black Foundation

Curated by ChEMBL


Assay Description
Antagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretion


Bioorg Med Chem 16: 2974-83 (2008)


Article DOI: 10.1016/j.bmc.2007.12.047
BindingDB Entry DOI: 10.7270/Q2FT8N8D
More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50411974
PNG
(CHEMBL259557)
Show SMILES Cc1nc(cs1)-c1cccc(NC(=O)CN2C(=O)N(CC(=O)C(C)(C)C)c3ccccc3N(C3CCCCC3)C2=O)c1
Show InChI InChI=1S/C32H37N5O4S/c1-21-33-25(20-42-21)22-11-10-12-23(17-22)34-29(39)19-36-30(40)35(18-28(38)32(2,3)4)26-15-8-9-16-27(26)37(31(36)41)24-13-6-5-7-14-24/h8-12,15-17,20,24H,5-7,13-14,18-19H2,1-4H3,(H,34,39)
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n/an/an/a 19.9n/an/an/an/an/a



James Black Foundation

Curated by ChEMBL


Assay Description
Antagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretion


Bioorg Med Chem 16: 2974-83 (2008)


Article DOI: 10.1016/j.bmc.2007.12.047
BindingDB Entry DOI: 10.7270/Q2FT8N8D
More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50410565
PNG
(CHEMBL194514)
Show SMILES Cc1ccccc1-c1nc(CCC2CCCCC2)c([nH]1)C(=O)Nc1cccc(c1)C(O)=O
Show InChI InChI=1S/C26H29N3O3/c1-17-8-5-6-13-21(17)24-28-22(15-14-18-9-3-2-4-10-18)23(29-24)25(30)27-20-12-7-11-19(16-20)26(31)32/h5-8,11-13,16,18H,2-4,9-10,14-15H2,1H3,(H,27,30)(H,28,29)(H,31,32)
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n/an/an/a 19.9n/an/an/an/an/a



James Black Foundation

Curated by ChEMBL


Assay Description
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach


J Med Chem 48: 6803-12 (2005)


Article DOI: 10.1021/jm0490686
BindingDB Entry DOI: 10.7270/Q2PV6MM7
More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50410569
PNG
(CHEMBL196441)
Show SMILES CC(C)c1nc(CCC23CC4CC(CC(C4)C2)C3)c([nH]1)C(=O)Nc1cccc(c1)C(O)=O
Show InChI InChI=1S/C26H33N3O3/c1-15(2)23-28-21(6-7-26-12-16-8-17(13-26)10-18(9-16)14-26)22(29-23)24(30)27-20-5-3-4-19(11-20)25(31)32/h3-5,11,15-18H,6-10,12-14H2,1-2H3,(H,27,30)(H,28,29)(H,31,32)
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n/an/an/a 20.9n/an/an/an/an/a



James Black Foundation

Curated by ChEMBL


Assay Description
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach


J Med Chem 48: 6803-12 (2005)


Article DOI: 10.1021/jm0490686
BindingDB Entry DOI: 10.7270/Q2PV6MM7
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50024317
PNG
(3-{2-[2-Amino-3-(1H-indol-3-yl)-propionylamino]-4-...)
Show SMILES CSCC[C@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C29H36N6O6S/c1-42-12-11-22(33-27(39)20(30)14-18-16-32-21-10-6-5-9-19(18)21)28(40)35-24(15-25(36)37)29(41)34-23(26(31)38)13-17-7-3-2-4-8-17/h2-10,16,20,22-24,32H,11-15,30H2,1H3,(H2,31,38)(H,33,39)(H,34,41)(H,35,40)(H,36,37)/t20-,22-,23-,24-/m0/s1
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n/an/an/a 22n/an/an/an/an/a



University of Montpellier

Curated by ChEMBL


Assay Description
Binding affinity to CCKB receptor (unknown origin) expressed in HEK cells after 4 hrs by RP-LC-ICPMS analysis


J Med Chem 61: 10173-10184 (2018)

More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50411976
PNG
(CHEMBL259276)
Show SMILES CC(C)(C)C(=O)CN1c2ccccc2N(C2CCCCC2)C(=O)N(CC(=O)Nc2cccc(CCC(O)=O)c2)C1=O
Show InChI InChI=1S/C31H38N4O6/c1-31(2,3)26(36)19-33-24-14-7-8-15-25(24)35(23-12-5-4-6-13-23)30(41)34(29(33)40)20-27(37)32-22-11-9-10-21(18-22)16-17-28(38)39/h7-11,14-15,18,23H,4-6,12-13,16-17,19-20H2,1-3H3,(H,32,37)(H,38,39)
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n/an/an/a 26.3n/an/an/an/an/a



James Black Foundation

Curated by ChEMBL


Assay Description
Antagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretion


Bioorg Med Chem 16: 2974-83 (2008)


Article DOI: 10.1016/j.bmc.2007.12.047
BindingDB Entry DOI: 10.7270/Q2FT8N8D
More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50410559
PNG
(CHEMBL197205)
Show SMILES CC(C)CCc1nc([nH]c1C(=O)Nc1cccc(c1)C(O)=O)-c1ccccc1C
Show InChI InChI=1S/C23H25N3O3/c1-14(2)11-12-19-20(26-21(25-19)18-10-5-4-7-15(18)3)22(27)24-17-9-6-8-16(13-17)23(28)29/h4-10,13-14H,11-12H2,1-3H3,(H,24,27)(H,25,26)(H,28,29)
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n/an/an/a 26.3n/an/an/an/an/a



James Black Foundation

Curated by ChEMBL


Assay Description
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach


J Med Chem 48: 6803-12 (2005)


Article DOI: 10.1021/jm0490686
BindingDB Entry DOI: 10.7270/Q2PV6MM7
More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50410848
PNG
(CHEMBL378388)
Show SMILES CC(C)(C)C(=O)CN1c2ccccc2C(=NN(CC(=O)Nc2cccc(O)c2)C1=O)C1CCCCC1
Show InChI InChI=1S/C28H34N4O4/c1-28(2,3)24(34)17-31-23-15-8-7-14-22(23)26(19-10-5-4-6-11-19)30-32(27(31)36)18-25(35)29-20-12-9-13-21(33)16-20/h7-9,12-16,19,33H,4-6,10-11,17-18H2,1-3H3,(H,29,35)
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n/an/an/a 27.5n/an/an/an/an/a



James Black Foundation

Curated by ChEMBL


Assay Description
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach


J Med Chem 49: 2253-61 (2006)


Article DOI: 10.1021/jm051219x
BindingDB Entry DOI: 10.7270/Q28K7B8B
More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50410837
PNG
(CHEMBL205751)
Show SMILES CNc1cccc(NC(=O)C[C@@H]2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1
Show InChI InChI=1S/C30H38N4O3/c1-30(2,3)26(35)19-34-25-16-9-8-15-23(25)28(20-11-6-5-7-12-20)33-24(29(34)37)18-27(36)32-22-14-10-13-21(17-22)31-4/h8-10,13-17,20,24,31H,5-7,11-12,18-19H2,1-4H3,(H,32,36)/t24-/m0/s1
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n/an/an/a 28.2n/an/an/an/an/a



James Black Foundation

Curated by ChEMBL


Assay Description
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach


J Med Chem 49: 2253-61 (2006)


Article DOI: 10.1021/jm051219x
BindingDB Entry DOI: 10.7270/Q28K7B8B
More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50410852
PNG
(CHEMBL379902)
Show SMILES CNc1cccc(NC(=O)C[C@H]2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1
Show InChI InChI=1S/C30H38N4O3/c1-30(2,3)26(35)19-34-25-16-9-8-15-23(25)28(20-11-6-5-7-12-20)33-24(29(34)37)18-27(36)32-22-14-10-13-21(17-22)31-4/h8-10,13-17,20,24,31H,5-7,11-12,18-19H2,1-4H3,(H,32,36)/t24-/m1/s1
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n/an/an/a 28.8n/an/an/an/an/a



James Black Foundation

Curated by ChEMBL


Assay Description
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach


J Med Chem 49: 2253-61 (2006)


Article DOI: 10.1021/jm051219x
BindingDB Entry DOI: 10.7270/Q28K7B8B
More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM81962
PNG
(S-L-365,260)
Show SMILES CN1c2ccccc2C(=N[C@@H](NC(=O)Nc2cccc(C)c2)C1=O)c1ccccc1
Show InChI InChI=1/C24H22N4O2/c1-16-9-8-12-18(15-16)25-24(30)27-22-23(29)28(2)20-14-7-6-13-19(20)21(26-22)17-10-4-3-5-11-17/h3-15,22H,1-2H3,(H2,25,27,30)/t22-/s2
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n/an/an/a 28.8n/an/an/an/an/a



James Black Foundation

Curated by ChEMBL


Assay Description
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach


J Med Chem 49: 2253-61 (2006)


Article DOI: 10.1021/jm051219x
BindingDB Entry DOI: 10.7270/Q28K7B8B
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50469547
PNG
(CHEMBL4278080)
Show SMILES CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCCCNC(=O)[C@H](CCCNC(N)=N)NC(=O)C[Se]c1ccccc1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1/C49H65N11O9SSe/c1-70-25-22-37(46(67)60-40(28-43(63)64)48(69)59-38(44(50)65)26-31-14-5-2-6-15-31)58-47(68)39(27-32-29-55-35-19-11-10-18-34(32)35)57-41(61)21-9-4-12-23-53-45(66)36(20-13-24-54-49(51)52)56-42(62)30-71-33-16-7-3-8-17-33/h2-3,5-8,10-11,14-19,29,36-40,55H,4,9,12-13,20-28,30H2,1H3,(H2,50,65)(H,53,66)(H,56,62)(H,57,61)(H,58,68)(H,59,69)(H,60,67)(H,63,64)(H4,51,52,54)/t36-,37-,38-,39-,40-/s2
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n/an/an/a 29n/an/an/an/an/a



University of Montpellier

Curated by ChEMBL


Assay Description
Binding affinity to CCKB receptor (unknown origin) expressed in HEK cells after 4 hrs by RP-LC-ICPMS analysis


J Med Chem 61: 10173-10184 (2018)

More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50410554
PNG
(CHEMBL436314)
Show SMILES Cc1ccc(NC(=O)c2[nH]c(nc2CCC23CC4CC(CC(C4)C2)C3)-c2ccccc2C)cc1C(O)=O
Show InChI InChI=1S/C31H35N3O3/c1-18-5-3-4-6-24(18)28-33-26(9-10-31-15-20-11-21(16-31)13-22(12-20)17-31)27(34-28)29(35)32-23-8-7-19(2)25(14-23)30(36)37/h3-8,14,20-22H,9-13,15-17H2,1-2H3,(H,32,35)(H,33,34)(H,36,37)
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n/an/an/a 33.1n/an/an/an/an/a



James Black Foundation

Curated by ChEMBL


Assay Description
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach


J Med Chem 48: 6803-12 (2005)


Article DOI: 10.1021/jm0490686
BindingDB Entry DOI: 10.7270/Q2PV6MM7
More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50410839
PNG
(CHEMBL202680)
Show SMILES CC(C)(C)C(=O)CN1c2ccccc2C(=NN(CC(=O)Nc2cccc(N)c2)C1=O)C1CCCCC1
Show InChI InChI=1S/C28H35N5O3/c1-28(2,3)24(34)17-32-23-15-8-7-14-22(23)26(19-10-5-4-6-11-19)31-33(27(32)36)18-25(35)30-21-13-9-12-20(29)16-21/h7-9,12-16,19H,4-6,10-11,17-18,29H2,1-3H3,(H,30,35)
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n/an/an/a 36.3n/an/an/an/an/a



James Black Foundation

Curated by ChEMBL


Assay Description
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach


J Med Chem 49: 2253-61 (2006)


Article DOI: 10.1021/jm051219x
BindingDB Entry DOI: 10.7270/Q28K7B8B
More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM50407326
PNG
(CHEMBL302027)
Show SMILES CC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NC(Cc1cccc(NC(=O)Nc2ccccc2C)c1)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](Cc1ccc(C)cc1)C(N)=O
Show InChI InChI=1S/C44H48N8O8/c1-25-15-17-28(18-16-25)20-35(40(45)56)49-43(59)38(23-39(54)55)51-41(57)36(21-29-10-8-11-31(19-29)48-44(60)52-33-13-6-4-9-26(33)2)50-42(58)37(47-27(3)53)22-30-24-46-34-14-7-5-12-32(30)34/h4-19,24,35-38,46H,20-23H2,1-3H3,(H2,45,56)(H,47,53)(H,49,59)(H,50,58)(H,51,57)(H,54,55)(H2,48,52,60)/t35-,36?,37+,38+/m0/s1
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n/an/an/a 39.8n/an/an/an/an/a



Glaxo Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity against CCK-8 induced responses in guinea pig gall bladder was determined


J Med Chem 38: 207-11 (1995)


Article DOI: 10.1021/jm00001a027
BindingDB Entry DOI: 10.7270/Q28C9XF9
More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM50407325
PNG
(CHEMBL408395)
Show SMILES CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NC(Cc1ccc(NC(=O)Nc2ccccc2C)cc1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](Cc1ccc(C)cc1)C(N)=O
Show InChI InChI=1S/C44H48N8O8/c1-25-12-14-28(15-13-25)20-35(40(45)56)49-43(59)38(23-39(54)55)51-41(57)36(21-29-16-18-31(19-17-29)48-44(60)52-33-10-6-4-8-26(33)2)50-42(58)37(47-27(3)53)22-30-24-46-34-11-7-5-9-32(30)34/h4-19,24,35-38,46H,20-23H2,1-3H3,(H2,45,56)(H,47,53)(H,49,59)(H,50,58)(H,51,57)(H,54,55)(H2,48,52,60)/t35-,36?,37+,38+/m1/s1
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n/an/an/a 39.8n/an/an/an/an/a



Glaxo Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity against CCK-8 induced responses in guinea pig gall bladder was determined


J Med Chem 38: 207-11 (1995)


Article DOI: 10.1021/jm00001a027
BindingDB Entry DOI: 10.7270/Q28C9XF9
More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50411973
PNG
(CHEMBL410114)
Show SMILES CC(C)(C)C(=O)CN1c2ccccc2N(C2CCCCCC2)C(=O)N(CC(=O)Nc2cccc(CC(O)=O)c2)C1=O
Show InChI InChI=1S/C31H38N4O6/c1-31(2,3)26(36)19-33-24-15-8-9-16-25(24)35(23-13-6-4-5-7-14-23)30(41)34(29(33)40)20-27(37)32-22-12-10-11-21(17-22)18-28(38)39/h8-12,15-17,23H,4-7,13-14,18-20H2,1-3H3,(H,32,37)(H,38,39)
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n/an/an/a 43.6n/an/an/an/an/a



James Black Foundation

Curated by ChEMBL


Assay Description
Antagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretion


Bioorg Med Chem 16: 2974-83 (2008)


Article DOI: 10.1016/j.bmc.2007.12.047
BindingDB Entry DOI: 10.7270/Q2FT8N8D
More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50411970
PNG
(CHEMBL404967)
Show SMILES CC(C)(C)C(=O)CN1c2ccccc2N(C2CCCCC2)C(=O)N(CC(=O)Nc2cccc(c2)-c2nc(=O)o[nH]2)C1=O
Show InChI InChI=1S/C30H34N6O6/c1-30(2,3)24(37)17-34-22-14-7-8-15-23(22)36(21-12-5-4-6-13-21)29(41)35(28(34)40)18-25(38)31-20-11-9-10-19(16-20)26-32-27(39)42-33-26/h7-11,14-16,21H,4-6,12-13,17-18H2,1-3H3,(H,31,38)(H,32,33,39)
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n/an/an/a 44.7n/an/an/an/an/a



James Black Foundation

Curated by ChEMBL


Assay Description
Antagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretion


Bioorg Med Chem 16: 2974-83 (2008)


Article DOI: 10.1016/j.bmc.2007.12.047
BindingDB Entry DOI: 10.7270/Q2FT8N8D
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50469546
PNG
(CHEMBL4286411)
Show SMILES CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCCCNC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC[Se]C)NC(C)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1/C48H70N12O10SSe/c1-29(61)55-36(20-24-72-3)45(68)57-34(17-12-22-53-48(50)51)43(66)52-21-11-5-8-18-40(62)56-38(26-31-28-54-33-16-10-9-15-32(31)33)46(69)58-35(19-23-71-2)44(67)60-39(27-41(63)64)47(70)59-37(42(49)65)25-30-13-6-4-7-14-30/h4,6-7,9-10,13-16,28,34-39,54H,5,8,11-12,17-27H2,1-3H3,(H2,49,65)(H,52,66)(H,55,61)(H,56,62)(H,57,68)(H,58,69)(H,59,70)(H,60,67)(H,63,64)(H4,50,51,53)/t34-,35-,36-,37-,38-,39-/s2
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n/an/an/a 46n/an/an/an/an/a



University of Montpellier

Curated by ChEMBL


Assay Description
Binding affinity to CCKB receptor (unknown origin) expressed in HEK cells after 4 hrs by RP-LC-ICPMS analysis


J Med Chem 61: 10173-10184 (2018)

More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50410836
PNG
(CHEMBL204683)
Show SMILES CNc1cccc(NC(=O)CN2N=C(c3ccccn3)c3ccccc3N(CC(=O)c3ccccc3C)C2=O)c1
Show InChI InChI=1S/C31H28N6O3/c1-21-10-3-4-13-24(21)28(38)19-36-27-16-6-5-14-25(27)30(26-15-7-8-17-33-26)35-37(31(36)40)20-29(39)34-23-12-9-11-22(18-23)32-2/h3-18,32H,19-20H2,1-2H3,(H,34,39)
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n/an/an/a 50.1n/an/an/an/an/a



James Black Foundation

Curated by ChEMBL


Assay Description
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach


J Med Chem 49: 2253-61 (2006)


Article DOI: 10.1021/jm051219x
BindingDB Entry DOI: 10.7270/Q28K7B8B
More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50410549
PNG
(CHEMBL433776)
Show SMILES CCCc1nc(CCC23CC4CC(CC(C4)C2)C3)c([nH]1)C(=O)Nc1cccc(c1)C(O)=O
Show InChI InChI=1S/C26H33N3O3/c1-2-4-22-28-21(7-8-26-13-16-9-17(14-26)11-18(10-16)15-26)23(29-22)24(30)27-20-6-3-5-19(12-20)25(31)32/h3,5-6,12,16-18H,2,4,7-11,13-15H2,1H3,(H,27,30)(H,28,29)(H,31,32)
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n/an/an/a 52.5n/an/an/an/an/a



James Black Foundation

Curated by ChEMBL


Assay Description
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach


J Med Chem 48: 6803-12 (2005)


Article DOI: 10.1021/jm0490686
BindingDB Entry DOI: 10.7270/Q2PV6MM7
More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50410563
PNG
(CHEMBL196580)
Show SMILES Cc1ccccc1-c1nc(CCC23CC4CC(CC(C4)C2)C3)c([nH]1)C(=O)Nc1cccc(c1)C(O)=O
Show InChI InChI=1S/C30H33N3O3/c1-18-5-2-3-8-24(18)27-32-25(9-10-30-15-19-11-20(16-30)13-21(12-19)17-30)26(33-27)28(34)31-23-7-4-6-22(14-23)29(35)36/h2-8,14,19-21H,9-13,15-17H2,1H3,(H,31,34)(H,32,33)(H,35,36)
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n/an/an/a 58.9n/an/an/an/an/a



James Black Foundation

Curated by ChEMBL


Assay Description
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach


J Med Chem 48: 6803-12 (2005)


Article DOI: 10.1021/jm0490686
BindingDB Entry DOI: 10.7270/Q2PV6MM7
More data for this
Ligand-Target Pair
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