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Found 186 Enz. Inhib. hit(s) with Target = 'Cytochrome P450 2E1'
TargetCytochrome P450 2E1(Homo sapiens (Human))
Mcgill University

LigandPNGBDBM92670(Auxiliary substrate, 16a)
Affinity DataKd:  1.30E+3nMAssay Description:All UV/Vis spectra of the enzyme-ligand complexes were obtained on a Cary 5000 UV/Vis spectrophotometer.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2E1(Homo sapiens (Human))
Mcgill University

LigandPNGBDBM92668(Auxiliary substrate, 1a)
Affinity DataKd:  1.40E+3nMAssay Description:All UV/Vis spectra of the enzyme-ligand complexes were obtained on a Cary 5000 UV/Vis spectrophotometer.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2E1(Homo sapiens (Human))
Mcgill University

LigandPNGBDBM92672(Auxiliary substrate, 20a)
Affinity DataKd:  1.60E+3nMAssay Description:All UV/Vis spectra of the enzyme-ligand complexes were obtained on a Cary 5000 UV/Vis spectrophotometer.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2E1(Homo sapiens (Human))
Mcgill University

LigandPNGBDBM92499(Omega-imidazolyl dodecanoic acid)
Affinity DataKd:  1.80E+3nMAssay Description:Binding assay using CYP2E1.More data for this Ligand-Target Pair
TargetCytochrome P450 2E1(Homo sapiens (Human))
Mcgill University

LigandPNGBDBM92666(Auxiliary substrate, 11a)
Affinity DataKd:  1.80E+3nMAssay Description:All UV/Vis spectra of the enzyme-ligand complexes were obtained on a Cary 5000 UV/Vis spectrophotometer.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2E1(Homo sapiens (Human))
Mcgill University

LigandPNGBDBM92669(Auxiliary substrate, 14a)
Affinity DataKd:  2.10E+3nMAssay Description:All UV/Vis spectra of the enzyme-ligand complexes were obtained on a Cary 5000 UV/Vis spectrophotometer.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2E1(Homo sapiens (Human))
Mcgill University

LigandPNGBDBM92665(Auxiliary substrate, 10a)
Affinity DataKd:  2.60E+3nMAssay Description:All UV/Vis spectra of the enzyme-ligand complexes were obtained on a Cary 5000 UV/Vis spectrophotometer.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2E1(Homo sapiens (Human))
Mcgill University

LigandPNGBDBM92667(Auxiliary substrate, 12a)
Affinity DataKd:  5.90E+3nMAssay Description:All UV/Vis spectra of the enzyme-ligand complexes were obtained on a Cary 5000 UV/Vis spectrophotometer.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2E1(Homo sapiens (Human))
Mcgill University

LigandPNGBDBM92498(Omega-imidazolyl decanoic acid)
Affinity DataKd:  9.00E+3nMAssay Description:Binding assay using CYP2E1.More data for this Ligand-Target Pair
TargetCytochrome P450 2E1(Homo sapiens (Human))
Mcgill University

LigandPNGBDBM92671(Auxiliary substrate, 18a)
Affinity DataKd:  1.20E+4nMAssay Description:All UV/Vis spectra of the enzyme-ligand complexes were obtained on a Cary 5000 UV/Vis spectrophotometer.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2E1(Homo sapiens (Human))
Mcgill University

LigandPNGBDBM92497(CHEMBL542051 | Omega-imidazolyl octanoic acid)
Affinity DataKd:  2.10E+4nMAssay Description:Binding assay using CYP2E1.More data for this Ligand-Target Pair
TargetCytochrome P450 2E1(Homo sapiens (Human))
Mcgill University

LigandPNGBDBM50240850((2-Isothiocyanato-ethyl)-benzene | CHEMBL151649 | ...)
Affinity DataKi:  9.98E+3nMAssay Description:Mechanism based inhibition of human cytochrome P450 2E1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2E1(Homo sapiens (Human))
Mcgill University

LigandPNGBDBM50240850((2-Isothiocyanato-ethyl)-benzene | CHEMBL151649 | ...)
Affinity DataKi:  1.10E+4nMAssay Description:Inhibition of human CYP2E1 expressed in Escherichia coli MV1304 assessed as reduction in 7-EFC O-de-ethylation activity by spectrofluorometry based d...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2E1(Homo sapiens (Human))
Mcgill University

LigandPNGBDBM50088490(CHEMBL3526979)
Affinity DataKi: >3.00E+4nMAssay Description:Inhibition of CYP2E1 in human liver microsomes using chlorzoxazone as substrate after 5 to 30 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2E1(Homo sapiens (Human))
Mcgill University

LigandPNGBDBM50363928(CHEMBL1951575)
Affinity DataKi: >3.00E+4nMAssay Description:Inhibition of CYP2E1 in human liver microsomes using chlorzoxazone as substrate after 5 to 30 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2E1(Homo sapiens (Human))
Mcgill University

LigandPNGBDBM50310823(CHEMBL1078442 | bergamottin)
Affinity DataKi:  4.00E+4nMAssay Description:Mechanism based inhibition of human cytochrome P450 2E1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2E1(Rattus norvegicus (rat))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50027780(CHEMBL1908229)
Affinity DataKi:  1.00E+5nMAssay Description:Mechanism based inhibition of rabbit cytochrome P450 CYP2E1 measured by 7-EFC O-deethylation activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2E1(Rattus norvegicus (rat))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50027781(Diallylsulfone)
Affinity DataKi:  1.88E+5nMAssay Description:Mechanism based inhibition of rat cytochrome P450 CYP2E1 measured by P-nitrophenol (PNP) hydroxylase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2E1(Rattus norvegicus (rat))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50592756(CHEMBL5182450)
Affinity DataKi:  1.96E+5nMAssay Description:Inhibition of CYP2E1 in rat liver microsomes using chlorzoxazone as substrateMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome P450 2E1(Rattus norvegicus (rat))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50027798(CHEMBL1908221)
Affinity DataKi:  1.00E+6nMAssay Description:Mechanism based inhibition of rabbit cytochrome P450 CYP2E1 measured by 7-EFC O-deethylation activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2E1(Homo sapiens (Human))
Mcgill University

LigandPNGBDBM50088436(BS-749 | CHEBI:76987 | Metacetamol)
Affinity DataKi:  9.50E+6nMAssay Description:Inhibition of human CYP2E1 assessed as chlorzoxazone 6-hydroxylase activity by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2E1(Homo sapiens (Human))
Mcgill University

LigandPNGBDBM50438845(CHEMBL2413882)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP2E1 in human liver microsomes assessed as chlorzoxazone 6-hydroxylation after 20 mins by LC-MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2E1(Homo sapiens (Human))
Mcgill University

LigandPNGBDBM50438846(CHEMBL2413881)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP2E1 in human liver microsomes assessed as chlorzoxazone 6-hydroxylation after 20 mins by LC-MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2E1(Homo sapiens (Human))
Mcgill University

LigandPNGBDBM50437753(CHEMBL2409564)
Affinity DataEC50: >1.00E+5nMAssay Description:Induction of CYP2E1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2E1(Rattus norvegicus (rat))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM31652(imidazole-dioxolane, 3)
Affinity DataIC50: >1.00E+5nMpH: 7.4 T: 2°CAssay Description:CYP2E1 hydroxylation of p-nitrophenol was determined by the spectrophotometric measurement of 4-nitrocatechol. Briefly, reaction mixture consisting o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2E1(Rattus norvegicus (rat))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM31656(imidazole-dioxolane, 8)
Affinity DataIC50: >1.00E+5nMpH: 7.4 T: 2°CAssay Description:CYP2E1 hydroxylation of p-nitrophenol was determined by the spectrophotometric measurement of 4-nitrocatechol. Briefly, reaction mixture consisting o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2E1(Rattus norvegicus (rat))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM31657(imidazole-dioxolane, 9)
Affinity DataIC50: >1.00E+5nMpH: 7.4 T: 2°CAssay Description:CYP2E1 hydroxylation of p-nitrophenol was determined by the spectrophotometric measurement of 4-nitrocatechol. Briefly, reaction mixture consisting o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2E1(Rattus norvegicus (rat))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM31658(imidazole-dioxolane, 10)
Affinity DataIC50: >1.00E+5nMpH: 7.4 T: 2°CAssay Description:CYP2E1 hydroxylation of p-nitrophenol was determined by the spectrophotometric measurement of 4-nitrocatechol. Briefly, reaction mixture consisting o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2E1(Rattus norvegicus (rat))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM31664(imidazole-dioxolane, 16)
Affinity DataIC50: >1.00E+5nMpH: 7.4Assay Description:CYP2E1 hydroxylation of p-nitrophenol was determined by the spectrophotometric measurement of 4-nitrocatechol. Briefly, reaction mixture consisting o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2E1(Rattus norvegicus (rat))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM31665(imidazole-dioxolane, 17)
Affinity DataIC50: >1.00E+5nMpH: 7.4Assay Description:CYP2E1 hydroxylation of p-nitrophenol was determined by the spectrophotometric measurement of 4-nitrocatechol. Briefly, reaction mixture consisting o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2E1(Rattus norvegicus (rat))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM31669(imidazole-dioxolane, 21)
Affinity DataIC50: >1.00E+5nMpH: 7.4Assay Description:CYP2E1 hydroxylation of p-nitrophenol was determined by the spectrophotometric measurement of 4-nitrocatechol. Briefly, reaction mixture consisting o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2E1(Rattus norvegicus (rat))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM31672(imidazole-dioxolane, 24)
Affinity DataIC50: >1.00E+5nMpH: 7.4Assay Description:CYP2E1 hydroxylation of p-nitrophenol was determined by the spectrophotometric measurement of 4-nitrocatechol. Briefly, reaction mixture consisting o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2E1(Rattus norvegicus (rat))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM31682(imidazole-dioxolane, 32)
Affinity DataIC50:  3.60E+3nMpH: 7.4Assay Description:CYP2E1 hydroxylation of p-nitrophenol was determined by the spectrophotometric measurement of 4-nitrocatechol. Briefly, reaction mixture consisting o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2E1(Homo sapiens (Human))
Mcgill University

LigandPNGBDBM50110231(3-(3-Nitro-phenyl)-3-{2-[4-(pyridin-2-ylamino)-but...)
Affinity DataIC50:  850nMAssay Description:The interaction of SC12 with cytochrome P450 enzymes was tested using Fluorescent High Throughput P450 assays (Gentest); The IC50s of the compounds w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2E1(Homo sapiens (Human))
Mcgill University

LigandPNGBDBM189322(US9173935, SC12)
Affinity DataIC50:  9.20E+3nMAssay Description:The interaction of SC12 with cytochrome P450 enzymes was tested using Fluorescent High Throughput P450 assays (Gentest); The IC50s of the compounds w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 2E1(Homo sapiens (Human))
Mcgill University

LigandPNGBDBM190404(US9180183, SC12)
Affinity DataIC50:  9.20E+3nMT: 2°CAssay Description:The interaction of SC12 with cytochrome P450 enzymes was tested using Fluorescent High Throughput P450 assays (Gentest); The IC50s of the compounds w...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 2E1(Homo sapiens (Human))
Mcgill University

LigandPNGBDBM50010231(CHEMBL107217 | Ditiocarb sodium | Sodium salt of D...)
Affinity DataIC50:  850nMT: 2°CAssay Description:The interaction of SC12 with cytochrome P450 enzymes was tested using Fluorescent High Throughput P450 assays (Gentest); The IC50s of the compounds w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2E1(Homo sapiens (Human))
Mcgill University

LigandPNGBDBM50017203(CHEMBL3287379)
Affinity DataIC50:  9.60E+3nMAssay Description:Inhibition of CYP2E1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2E1(Homo sapiens (Human))
Mcgill University

LigandPNGBDBM50158921(5-Pyridin-3-yl-furan-2-carbaldehyde oxime | 5-Pyri...)
Affinity DataIC50: >4.00E+5nMAssay Description:Inhibitory concentration value against human cytochrome P-450 2E1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2E1(Homo sapiens (Human))
Mcgill University

LigandPNGBDBM50158921(5-Pyridin-3-yl-furan-2-carbaldehyde oxime | 5-Pyri...)
Affinity DataIC50: >4.00E+5nMAssay Description:Inhibitory concentration value against human cytochrome P-450 2E1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2E1(Homo sapiens (Human))
Mcgill University

LigandPNGBDBM12341(CHEMBL178681 | CHEMBL359657 | US8609708, 1 | US860...)
Affinity DataIC50:  4.02E+4nMAssay Description:Inhibitory concentration value against human cytochrome P-450 2E1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2E1(Homo sapiens (Human))
Mcgill University

LigandPNGBDBM50032693(CHEBI:66901 | Ivacaftor | Kalydeco | VX-770)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP2E1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2E1(Homo sapiens (Human))
Mcgill University

LigandPNGBDBM50059654(CHEMBL2144409)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2E1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2E1(Homo sapiens (Human))
Mcgill University

LigandPNGBDBM50225074((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2E1 in human liver microsomes assessed as chlorzoxazone 6-hydroxylation after 3 mins by LC-MS/MS analysis in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2E1(Homo sapiens (Human))
Mcgill University

LigandPNGBDBM11543((1S,3S,5S)-2-[(2S)-2-amino-2-(3,5-dihydroxyadamant...)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of CYP2E1 in human liver microsomes assessed as chlorzoxazone 6-hydroxylation after 3 mins by LC-MS/MS analysis in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2E1(Homo sapiens (Human))
Mcgill University

LigandPNGBDBM50225074((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2E1 in human liver microsomes assessed as chlorzoxazone 6-hydroxylation preincubated for 15 mins by LC-MS/MS analysis in presence of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2E1(Homo sapiens (Human))
Mcgill University

LigandPNGBDBM11543((1S,3S,5S)-2-[(2S)-2-amino-2-(3,5-dihydroxyadamant...)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of CYP2E1 in human liver microsomes assessed as chlorzoxazone 6-hydroxylation preincubated for 15 mins by LC-MS/MS analysis in presence of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2E1(Homo sapiens (Human))
Mcgill University

LigandPNGBDBM50209506(CHEMBL266212 | N-(2-(4-(4-(3,4-dimethoxybenzyl)pip...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human CYP2E1 expressed in insect microsome after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2E1(Homo sapiens (Human))
Mcgill University

LigandPNGBDBM50075373(1N-{4-[2-(6,7-dimethoxy-1,2,3,4-tetrahydro-2-isoqu...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human CYP2E1 expressed in insect microsome after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2E1(Homo sapiens (Human))
Mcgill University

LigandPNGBDBM50209505(CHEMBL244239 | N-(2-((2-((3,4-dimethoxyphenethyl)(...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human CYP2E1 expressed in insect microsome after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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