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Found 119 Enz. Inhib. hit(s) with Target = 'Hemagglutinin'
TargetHemagglutinin(Influenza A virus (strain A/Wilson-Smith/1933 H1N1...)
The Third Affiliated Hospital Of Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50596582(CHEMBL5202013)
Affinity DataKd:  0.00700nMAssay Description:Binding affinity to Influenza A Puerto Rico/8/1934/H1N1 hemagglutin assessed as dissociation constant by surface plasmon resonance assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHemagglutinin(Influenza A virus (strain A/Wilson-Smith/1933 H1N1...)
The Third Affiliated Hospital Of Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50596583(CHEMBL5183382)
Affinity DataKd:  0.00700nMAssay Description:Binding affinity to Influenza A Puerto Rico/8/1934/H1N1 hemagglutin assessed as dissociation constant by surface plasmon resonance assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHemagglutinin(Influenza A virus (strain A/Wilson-Smith/1933 H1N1...)
The Third Affiliated Hospital Of Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50524786(CHEMBL4467587)
Affinity DataKd:  1.20nMAssay Description:Binding affinity to influenza A virus hemagglutin by surface plasmon resonance assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetHemagglutinin(Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)
Keio University

Curated by ChEMBL
LigandPNGBDBM50320025(ARLSPTMVHPNGAQP | CHEMBL1084188)
Affinity DataKd:  7.80nMAssay Description:Binding affinity to Influenza A virus (A/Puerto Rico/8/34(H1N1)) hemagglutinin by phage ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHemagglutinin(Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)
Keio University

Curated by ChEMBL
LigandPNGBDBM50320028(CHEMBL1084191 | GRVPVFGLSPLFKVE)
Affinity DataKd:  7.80nMAssay Description:Binding affinity to Influenza A virus (A/Puerto Rico/8/34(H1N1)) hemagglutinin by phage ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHemagglutinin(Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)
Keio University

Curated by ChEMBL
LigandPNGBDBM50320027(CHEMBL1084190 | GRPPDSVFRSRGWLS)
Affinity DataKd:  11nMAssay Description:Binding affinity to Influenza A virus (A/Puerto Rico/8/34(H1N1)) hemagglutinin by phage ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHemagglutinin(Influenza A virus (strain A/Wilson-Smith/1933 H1N1...)
The Third Affiliated Hospital Of Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50512749(CHEMBL4565295)
Affinity DataKd:  16nMAssay Description:Binding affinity to hemagglutinin by SPR assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetHemagglutinin(Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)
Keio University

Curated by ChEMBL
LigandPNGBDBM50320029(CHEMBL1084192 | IDIAFSSLALADISR)
Affinity DataKd:  19nMAssay Description:Binding affinity to Influenza A virus (A/Puerto Rico/8/34(H1N1)) hemagglutinin by phage ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHemagglutinin(Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)
Keio University

Curated by ChEMBL
LigandPNGBDBM50320026(CHEMBL1084189 | EPYGFIAFSRAAHSP)
Affinity DataKd:  30nMAssay Description:Binding affinity to Influenza A virus (A/Puerto Rico/8/34(H1N1)) hemagglutinin by phage ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHemagglutinin(Influenza A virus (strain A/Wilson-Smith/1933 H1N1...)
The Third Affiliated Hospital Of Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50579620(CHEMBL4878363)
Affinity DataKd:  446nMAssay Description:Inhibition of CM5 chip immobilized Influenza A virus (A/Viet Nam/1203/2004(H5N1)) HA by SPR methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHemagglutinin(Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)
Keio University

Curated by ChEMBL
LigandPNGBDBM50579619(CHEMBL4855404)
Affinity DataKd:  2.63E+3nMAssay Description:Binding affinity to CM5 chip immobilized Influenza A virus (A/Michigan/45/2015) (H1N1)) hemagglutin assessed as dissociation constant by surface plas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHemagglutinin(Influenza A virus (strain A/Wilson-Smith/1933 H1N1...)
The Third Affiliated Hospital Of Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50605865(CHEMBL5202311)
Affinity DataKd:  3.18E+3nMAssay Description:Binding affinity to recombinant influenza A hemagglutinin assessed as dissociation constant by SPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHemagglutinin(Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)
Keio University

Curated by ChEMBL
LigandPNGBDBM50542720(CHEMBL4645411)
Affinity DataKd:  4.50E+3nMAssay Description:Binding affinity to Influenza A virus (A/Puerto Rico/8/1934(H1N1)) Hemagglutinin at 1.5625 to 50 uM by SPR assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetHemagglutinin(Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)
Keio University

Curated by ChEMBL
LigandPNGBDBM50542719(CHEMBL4639026)
Affinity DataKd:  6.30E+3nMAssay Description:Binding affinity to Influenza A virus (A/Puerto Rico/8/1934(H1N1)) Hemagglutinin at 1.5625 to 50 uM by SPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHemagglutinin(Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)
Keio University

Curated by ChEMBL
LigandPNGBDBM50542719(CHEMBL4639026)
Affinity DataKd:  6.90E+3nMAssay Description:Binding affinity to Influenza A virus (A/California/04/2009(H1N1)) Hemagglutinin at 1.5625 to 50 uM by SPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHemagglutinin(Influenza A virus (strain A/Wilson-Smith/1933 H1N1...)
The Third Affiliated Hospital Of Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50346601(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
Affinity DataKd:  1.09E+4nMAssay Description:Binding affinity to recombinant influenza A hemagglutinin assessed as dissociation constant by SPR assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHemagglutinin(Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)
Keio University

Curated by ChEMBL
LigandPNGBDBM83797(6-Bromo-4-dimethylaminomethyl-5-hydroxy-1-methyl-2...)
Affinity DataKd:  1.11E+4nMAssay Description:Binding affinity to Influenza A virus (A/Puerto Rico/8/1934(H1N1)) Hemagglutinin at 1.5625 to 50 uM by SPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHemagglutinin(Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)
Keio University

Curated by ChEMBL
LigandPNGBDBM50529725(CHEMBL4569515)
Affinity DataKd:  1.56E+4nMAssay Description:Binding affinity to recombinant Influenza A virus (A/California/04/2009 (H1N1)) hemagglutinin by SPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHemagglutinin(Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)
Keio University

Curated by ChEMBL
LigandPNGBDBM50529725(CHEMBL4569515)
Affinity DataKd:  1.56E+4nMAssay Description:Binding affinity to recombinant Influenza A virus (A/California/04/2009 (H1N1)) hemagglutinin by SPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHemagglutinin(Influenza A virus (strain A/Wilson-Smith/1933 H1N1...)
The Third Affiliated Hospital Of Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50498193(NEOECHINULIN B)
Affinity DataKd:  3.20E+4nMAssay Description:Binding affinity to influenza A virus A/WSN/33 (H1N1) Hemagglutinin by surface Plasmon resonance assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHemagglutinin(Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)
Keio University

Curated by ChEMBL
LigandPNGBDBM50529726(CHEMBL4464620)
Affinity DataKd:  3.60E+4nMAssay Description:Binding affinity to recombinant Influenza A virus (A/California/04/2009 (H1N1)) hemagglutinin by SPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHemagglutinin(Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)
Keio University

Curated by ChEMBL
LigandPNGBDBM50529726(CHEMBL4464620)
Affinity DataKd:  3.60E+4nMAssay Description:Binding affinity to recombinant Influenza A virus (A/California/04/2009 (H1N1)) hemagglutinin by SPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHemagglutinin(Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)
Keio University

Curated by ChEMBL
LigandPNGBDBM50148911((3beta)-3-hydroxyurs-12-en-28-oic acid | 3beta-hyd...)
Affinity DataKd:  4.65E+4nMAssay Description:Binding affinity to recombinant Influenza A virus (A/California/04/2009 (H1N1)) hemagglutinin by SPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHemagglutinin(Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)
Keio University

Curated by ChEMBL
LigandPNGBDBM50148911((3beta)-3-hydroxyurs-12-en-28-oic acid | 3beta-hyd...)
Affinity DataKd:  4.65E+4nMAssay Description:Binding affinity to recombinant Influenza A virus (A/California/04/2009 (H1N1)) hemagglutinin by SPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHemagglutinin(Influenza A virus (strain A/Wilson-Smith/1933 H1N1...)
The Third Affiliated Hospital Of Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50498194(NEOECHINULIN A)
Affinity DataKd:  9.80E+4nMAssay Description:Binding affinity to influenza A virus A/WSN/33 (H1N1) Hemagglutinin by surface Plasmon resonance assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHemagglutinin(Influenza A virus (A/Shangdong/9/93(H3N2)))
Gilead Sciences

LigandPNGBDBM4934((2R,3R,4S)-4-carbamimidamido-3-acetamido-2-[(1R,2R...)
Affinity DataKi:  1nM ΔG°:  -53.4kJ/mole IC50:  5nMpH: 6.5 T: 2°CAssay Description:A standard fluorimetric assay was used to measure influenza virus neuraminidase activity. The substrate 2 -(4-methylumbelliferyl)-alpha-D-acetylneura...More data for this Ligand-Target Pair
In DepthDetails Article
TargetHemagglutinin(Influenza A virus (A/Shangdong/9/93(H3N2)))
Gilead Sciences

LigandPNGBDBM5210(3-carbamimidamido-4-acetamido-5-[(1S,2R)-1,2,3-tri...)
Affinity DataKi: >1.00E+5nM ΔG°: >-23.7kJ/mole IC50: >1.00E+5nMpH: 6.5 T: 2°CAssay Description:A standard fluorimetric assay was used to measure influenza virus neuraminidase activity. The substrate 2 -(4-methylumbelliferyl)-alpha-D-acetylneura...More data for this Ligand-Target Pair
In DepthDetails Article
TargetHemagglutinin/Neuraminidase()
Sunshine Lake Pharma

US Patent
LigandPNGBDBM493570(US10987354, Example 39)
Affinity DataEC50:  1.22nMAssay Description:MDCK cells (Madin-Daby canine kidney cells) were seeded in a 384-well plate with 2000 cells per well and cultured at 37° C. under 5% CO2 condition ov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHemagglutinin/Neuraminidase()
Sunshine Lake Pharma

US Patent
LigandPNGBDBM493571(US10987354, Example 49)
Affinity DataEC50:  0.521nMAssay Description:MDCK cells (Madin-Daby canine kidney cells) were seeded in a 384-well plate with 2000 cells per well and cultured at 37° C. under 5% CO2 condition ov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHemagglutinin/Neuraminidase()
Sunshine Lake Pharma

US Patent
LigandPNGBDBM493572(US10987354, Example 55)
Affinity DataEC50:  0.680nMAssay Description:MDCK cells (Madin-Daby canine kidney cells) were seeded in a 384-well plate with 2000 cells per well and cultured at 37° C. under 5% CO2 condition ov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHemagglutinin/Neuraminidase()
Sunshine Lake Pharma

US Patent
LigandPNGBDBM493573(US10987354, Example 62)
Affinity DataEC50:  0.0110nMAssay Description:MDCK cells (Madin-Daby canine kidney cells) were seeded in a 384-well plate with 2000 cells per well and cultured at 37° C. under 5% CO2 condition ov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHemagglutinin/Neuraminidase()
Sunshine Lake Pharma

US Patent
LigandPNGBDBM493574(US10987354, Example 63)
Affinity DataEC50:  0.0790nMAssay Description:MDCK cells (Madin-Daby canine kidney cells) were seeded in a 384-well plate with 2000 cells per well and cultured at 37° C. under 5% CO2 condition ov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHemagglutinin/Neuraminidase()
Sunshine Lake Pharma

US Patent
LigandPNGBDBM493575(US10987354, Example 64)
Affinity DataEC50:  0.887nMAssay Description:MDCK cells (Madin-Daby canine kidney cells) were seeded in a 384-well plate with 2000 cells per well and cultured at 37° C. under 5% CO2 condition ov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHemagglutinin/Neuraminidase()
Sunshine Lake Pharma

US Patent
LigandPNGBDBM493576(US10987354, Example 66)
Affinity DataEC50:  0.274nMAssay Description:MDCK cells (Madin-Daby canine kidney cells) were seeded in a 384-well plate with 2000 cells per well and cultured at 37° C. under 5% CO2 condition ov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHemagglutinin(Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)
Keio University

Curated by ChEMBL
LigandPNGBDBM50551836(CHEMBL3288937)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of Influenza A virus (A/PR 8/34 (H1N1)) hemagglutinin transfected in human HeLa cells assessed as reduction in low pH-indued polykaryon fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHemagglutinin()
SociÉTÉ

US Patent
LigandPNGBDBM525149(US10988505, Comparative #1)
Affinity DataEC50:  5.07E+3nMAssay Description:The ability of the tested compound to block influenza virus replication (PR8 and X31) in Calu-3 human bronchial epithelial cells was evaluated as des...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHemagglutinin(Influenza A virus (strain A/X-31 H3N2))
SociÉTÉ

US Patent
LigandPNGBDBM525149(US10988505, Comparative #1)
Affinity DataEC50:  7.70E+3nMAssay Description:The ability of the tested compound to block influenza virus replication (PR8 and X31) in Calu-3 human bronchial epithelial cells was evaluated as des...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHemagglutinin(Influenza A virus (strain A/X-31 H3N2))
SociÉTÉ

US Patent
LigandPNGBDBM236493(US10988505, Comparative #2 | US9365853, 4)
Affinity DataEC50:  5.69E+3nMAssay Description:The ability of the tested compound to block influenza virus replication (PR8 and X31) in Calu-3 human bronchial epithelial cells was evaluated as des...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHemagglutinin()
SociÉTÉ

US Patent
LigandPNGBDBM525151(US10988505, Example 1)
Affinity DataEC50:  27.3nMAssay Description:The ability of the tested compound to block influenza virus replication (PR8 and X31) in Calu-3 human bronchial epithelial cells was evaluated as des...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHemagglutinin(Influenza A virus (strain A/X-31 H3N2))
SociÉTÉ

US Patent
LigandPNGBDBM525151(US10988505, Example 1)
Affinity DataEC50:  20.9nMAssay Description:The ability of the tested compound to block influenza virus replication (PR8 and X31) in Calu-3 human bronchial epithelial cells was evaluated as des...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHemagglutinin()
SociÉTÉ

US Patent
LigandPNGBDBM525152(Ms-QFR-kbt | N-0385 | US10988505, Example 2)
Affinity DataEC50:  1.56nMAssay Description:The ability of the tested compound to block influenza virus replication (PR8 and X31) in Calu-3 human bronchial epithelial cells was evaluated as des...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHemagglutinin(Influenza A virus (strain A/X-31 H3N2))
SociÉTÉ

US Patent
LigandPNGBDBM525152(Ms-QFR-kbt | N-0385 | US10988505, Example 2)
Affinity DataEC50:  9.33nMAssay Description:The ability of the tested compound to block influenza virus replication (PR8 and X31) in Calu-3 human bronchial epithelial cells was evaluated as des...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHemagglutinin()
SociÉTÉ

US Patent
LigandPNGBDBM525153(Ac-QFR-kbt | N-0386 | US10988505, Example 3)
Affinity DataEC50:  2.28nMAssay Description:The ability of the tested compound to block influenza virus replication (PR8 and X31) in Calu-3 human bronchial epithelial cells was evaluated as des...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHemagglutinin(Influenza A virus (strain A/X-31 H3N2))
SociÉTÉ

US Patent
LigandPNGBDBM525153(Ac-QFR-kbt | N-0386 | US10988505, Example 3)
Affinity DataEC50:  34nMAssay Description:The ability of the tested compound to block influenza virus replication (PR8 and X31) in Calu-3 human bronchial epithelial cells was evaluated as des...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHemagglutinin(Influenza A virus (strain A/Aichi/2/1968 H3N2))
Individual

US Patent
LigandPNGBDBM535847(US11241393, Sil 2)
Affinity DataIC50:  7.38E+3nMAssay Description:The cytopathic effect (CPE) inhibition test is used for measuring the antiviral effect. Monolayer cells in 96-well plates are inoculated with 0.1 ml ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHemagglutinin(Influenza A virus (strain A/Aichi/2/1968 H3N2))
Individual

US Patent
LigandPNGBDBM535848(US11241393, Sil 3)
Affinity DataIC50:  6.60E+3nMAssay Description:The cytopathic effect (CPE) inhibition test is used for measuring the antiviral effect. Monolayer cells in 96-well plates are inoculated with 0.1 ml ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHemagglutinin(Influenza A virus (strain A/Aichi/2/1968 H3N2))
Individual

US Patent
LigandPNGBDBM535849(US11241393, Sil 25)
Affinity DataIC50:  9.60E+3nMAssay Description:The cytopathic effect (CPE) inhibition test is used for measuring the antiviral effect. Monolayer cells in 96-well plates are inoculated with 0.1 ml ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHemagglutinin(Influenza A virus (strain A/Aichi/2/1968 H3N2))
Individual

US Patent
LigandPNGBDBM50216627((alpha-methyl-1-adamantyl)methylamine | 1-Adamanta...)
Affinity DataIC50:  30nMAssay Description:The cytopathic effect (CPE) inhibition test is used for measuring the antiviral effect. Monolayer cells in 96-well plates are inoculated with 0.1 ml ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHemagglutinin()
Janssen Sciences Ireland Uc

US Patent
LigandPNGBDBM611014(US10626108, Compound 6)
Affinity DataIC50:  130nMAssay Description:The in vitro antiviral activity of the compounds was determined using a cell-based antiviral assay. In this assay, the cytopathic effect (CPE) in Mad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHemagglutinin()
Janssen Sciences Ireland Uc

US Patent
LigandPNGBDBM611015(US10626108, Compound 13)
Affinity DataIC50:  1nMAssay Description:The in vitro antiviral activity of the compounds was determined using a cell-based antiviral assay. In this assay, the cytopathic effect (CPE) in Mad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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