BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 14079 hits Enz. Inhib. hit(s) with Target = 'Metabotropic glutamate receptor'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))
BDBM50318382
PNG
(3-[pyridine-2-yl)ethynyl]cyclohex-2-enone-O-fluoro...)
Show SMILES FCCOCCO\N=C1/CCCC(=C1)C#Cc1ccccn1
Show InChI InChI=1S/C17H19FN2O2/c18-9-11-21-12-13-22-20-17-6-3-4-15(14-17)7-8-16-5-1-2-10-19-16/h1-2,5,10,14H,3-4,6,9,11-13H2/b20-17+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 0.600n/an/an/an/an/a



ETH Zurich

Curated by ChEMBL


Assay Description
Binding affinity to mGluR5 ligand binding site 1 in Sprague-Dawley rat brain P2 membrane after 45 mins by gamma counting


J Med Chem 53: 4009-17 (2010)


Article DOI: 10.1021/jm901850k
BindingDB Entry DOI: 10.7270/Q2T72HMH
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50257555
PNG
(CHEMBL4074664)
Show SMILES Cc1ccc(Oc2ccc(cc2Cl)-c2ccn3c(CC4CC4)nnc3c2Cl)c(C)n1
Show InChI InChI=1S/C23H20Cl2N4O/c1-13-3-7-19(14(2)26-13)30-20-8-6-16(12-18(20)24)17-9-10-29-21(11-15-4-5-15)27-28-23(29)22(17)25/h3,6-10,12,15H,4-5,11H2,1-2H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/a 1n/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes assessed as increase in glutamate-induced...


J Med Chem 60: 6704-6720 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50257595
PNG
(CHEMBL4087196)
Show SMILES Fc1cc(ccc1NC1CC1)-c1ccn2c(CC3CC3)nnc2c1C(F)(F)F
Show InChI InChI=1S/C20H18F4N4/c21-15-10-12(3-6-16(15)25-13-4-5-13)14-7-8-28-17(9-11-1-2-11)26-27-19(28)18(14)20(22,23)24/h3,6-8,10-11,13,25H,1-2,4-5,9H2
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/a 1.10n/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Binding affinity to human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes by scintillation proximity assay


J Med Chem 60: 6704-6720 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50257606
PNG
(CHEMBL4073628)
Show SMILES FC(F)(F)c1c(ccn2c(CC3CC3)nnc12)-c1ccc(NC2CC2)c(Cl)c1
Show InChI InChI=1S/C20H18ClF3N4/c21-15-10-12(3-6-16(15)25-13-4-5-13)14-7-8-28-17(9-11-1-2-11)26-27-19(28)18(14)20(22,23)24/h3,6-8,10-11,13,25H,1-2,4-5,9H2
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/an/a 1.20n/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes assessed as increase in glutamate-induced...


J Med Chem 60: 6704-6720 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50257518
PNG
(CHEMBL4063313)
Show SMILES O[C@@]1(CC[C@@H](CC1)Nc1ccc(cc1Cl)-c1ccn2c(CC3CC3)nnc2c1C(F)(F)F)C1CC1
Show InChI InChI=1/C26H28ClF3N4O/c27-20-14-16(3-6-21(20)31-18-7-10-25(35,11-8-18)17-4-5-17)19-9-12-34-22(13-15-1-2-15)32-33-24(34)23(19)26(28,29)30/h3,6,9,12,14-15,17-18,31,35H,1-2,4-5,7-8,10-11,13H2/t18-,25+
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/a 1.5n/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Binding affinity to human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes by scintillation proximity assay


J Med Chem 60: 6704-6720 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50257517
PNG
(CHEMBL4093657)
Show SMILES COc1ccc(CNc2ccc(cc2)-c2ccn3c(CC4CC4)nnc3c2C(F)(F)F)cn1
Show InChI InChI=1S/C24H22F3N5O/c1-33-21-9-4-16(14-29-21)13-28-18-7-5-17(6-8-18)19-10-11-32-20(12-15-2-3-15)30-31-23(32)22(19)24(25,26)27/h4-11,14-15,28H,2-3,12-13H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

PubMed
n/an/an/a 2n/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Displacement of [3H]-JNJ46281222 from human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes after 60 mins by microbeta counting a...


J Med Chem 60: 6704-6720 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50257523
PNG
(CHEMBL4067298)
Show SMILES CCOCc1nnc2c(c(ccn12)-c1ccc(Oc2ccc(C)nc2C)c(F)c1)C(F)(F)F
Show InChI InChI=1S/C23H20F4N4O2/c1-4-32-12-20-29-30-22-21(23(25,26)27)16(9-10-31(20)22)15-6-8-19(17(24)11-15)33-18-7-5-13(2)28-14(18)3/h5-11H,4,12H2,1-3H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/a 2.10n/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes assessed as increase in glutamate-induced...


J Med Chem 60: 6704-6720 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50257605
PNG
(CHEMBL4088239)
Show SMILES CC(C)Nc1ccc(cc1F)-c1ccn2c(CC3CC3)nnc2c1C(F)(F)F
Show InChI InChI=1S/C20H20F4N4/c1-11(2)25-16-6-5-13(10-15(16)21)14-7-8-28-17(9-12-3-4-12)26-27-19(28)18(14)20(22,23)24/h5-8,10-12,25H,3-4,9H2,1-2H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/a 2.20n/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes assessed as increase in glutamate-induced...


J Med Chem 60: 6704-6720 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))
BDBM50198702
PNG
((E)-3-((6-methylpyridin-2-yl)ethynyl)cyclohex-2-en...)
Show SMILES CO\N=C1/CCCC(=C1)C#Cc1cccc(C)n1
Show InChI InChI=1S/C15H16N2O/c1-12-5-3-7-14(16-12)10-9-13-6-4-8-15(11-13)17-18-2/h3,5,7,11H,4,6,8H2,1-2H3/b17-15+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 2.30n/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Binding affinity at mGluR5 in rat brain membrane


Bioorg Med Chem 15: 903-14 (2006)


Article DOI: 10.1016/j.bmc.2006.10.038
BindingDB Entry DOI: 10.7270/Q25D8SNC
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50257524
PNG
(CHEMBL4080973)
Show SMILES Cc1ccc(Oc2ccc(cc2F)-c2ccn3c(CC4CC4)nnc3c2C(F)(F)F)c(C)n1
Show InChI InChI=1S/C24H20F4N4O/c1-13-3-7-19(14(2)29-13)33-20-8-6-16(12-18(20)25)17-9-10-32-21(11-15-4-5-15)30-31-23(32)22(17)24(26,27)28/h3,6-10,12,15H,4-5,11H2,1-2H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/a 2.5n/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Binding affinity to human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes by scintillation proximity assay


J Med Chem 60: 6704-6720 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50257525
PNG
(CHEMBL4091370)
Show SMILES COc1ccc(CNc2ccc(cc2F)-c2ccn3c(CC4CC4)nnc3c2C(F)(F)F)cn1
Show InChI InChI=1S/C24H21F4N5O/c1-34-21-7-4-15(13-30-21)12-29-19-6-5-16(11-18(19)25)17-8-9-33-20(10-14-2-3-14)31-32-23(33)22(17)24(26,27)28/h4-9,11,13-14,29H,2-3,10,12H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/a 2.90n/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes assessed as increase in glutamate-induced...


J Med Chem 60: 6704-6720 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50257548
PNG
(CHEMBL4104081)
Show SMILES O[C@H]1CC[C@@H](CC1)Nc1ccc(cc1Cl)-c1ccn2c(CC3CC3)nnc2c1C(F)(F)F
Show InChI InChI=1/C23H24ClF3N4O/c24-18-12-14(3-8-19(18)28-15-4-6-16(32)7-5-15)17-9-10-31-20(11-13-1-2-13)29-30-22(31)21(17)23(25,26)27/h3,8-10,12-13,15-16,28,32H,1-2,4-7,11H2/t15-,16-
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/a 3n/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Binding affinity to human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes by scintillation proximity assay


J Med Chem 60: 6704-6720 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50257551
PNG
(CHEMBL4077609)
Show SMILES O[C@H]1CC[C@@H](CC1)Oc1ccc(cc1Cl)-c1ccn2c(CC3CC3)nnc2c1C(F)(F)F
Show InChI InChI=1/C23H23ClF3N3O2/c24-18-12-14(3-8-19(18)32-16-6-4-15(31)5-7-16)17-9-10-30-20(11-13-1-2-13)28-29-22(30)21(17)23(25,26)27/h3,8-10,12-13,15-16,31H,1-2,4-7,11H2/t15-,16-
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/a 3n/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Binding affinity to human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes by scintillation proximity assay


J Med Chem 60: 6704-6720 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50257602
PNG
(CHEMBL4093792)
Show SMILES Cc1ccc(Oc2ccc(cc2F)-c2ccn3c(CC(F)(F)F)nnc3c2Cl)c(C)n1
Show InChI InChI=1S/C21H15ClF4N4O/c1-11-3-5-16(12(2)27-11)31-17-6-4-13(9-15(17)23)14-7-8-30-18(10-21(24,25)26)28-29-20(30)19(14)22/h3-9H,10H2,1-2H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/a 3.30n/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Binding affinity to human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes by scintillation proximity assay


J Med Chem 60: 6704-6720 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50257593
PNG
(CHEMBL4067421)
Show SMILES CC(C)Nc1ccc(cc1Cl)-c1ccn2c(CC3CC3)nnc2c1C(F)(F)F
Show InChI InChI=1S/C20H20ClF3N4/c1-11(2)25-16-6-5-13(10-15(16)21)14-7-8-28-17(9-12-3-4-12)26-27-19(28)18(14)20(22,23)24/h5-8,10-12,25H,3-4,9H2,1-2H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/a 3.40n/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Displacement of [3H]-JNJ46281222 from human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes after 60 mins by microbeta counting a...


J Med Chem 60: 6704-6720 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50257546
PNG
(CHEMBL4064589)
Show SMILES FC(F)(F)c1c(ccn2c(CC3CC3)nnc12)-c1ccc(NC2CCOCC2)c(Cl)c1
Show InChI InChI=1S/C22H22ClF3N4O/c23-17-12-14(3-4-18(17)27-15-6-9-31-10-7-15)16-5-8-30-19(11-13-1-2-13)28-29-21(30)20(16)22(24,25)26/h3-5,8,12-13,15,27H,1-2,6-7,9-11H2
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/a 3.80n/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Displacement of [3H]-JNJ46281222 from human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes after 60 mins by microbeta counting a...


J Med Chem 60: 6704-6720 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50257596
PNG
(CHEMBL4060306)
Show SMILES Clc1cc(ccc1NC1CC1)-c1ccn2c(CC3CC3)nnc2c1Cl
Show InChI InChI=1S/C19H18Cl2N4/c20-15-10-12(3-6-16(15)22-13-4-5-13)14-7-8-25-17(9-11-1-2-11)23-24-19(25)18(14)21/h3,6-8,10-11,13,22H,1-2,4-5,9H2
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/a 6.10n/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes assessed as increase in glutamate-induced...


J Med Chem 60: 6704-6720 (2017)

More data for this
Ligand-Target Pair
GRM8


(Homo sapiens (Human))
BDBM50157910
PNG
((2S,3R)-2-((S)-Amino-carboxy-methyl)-3-hydroxymeth...)
Show SMILES N[C@@H]([C@H]1[C@@H](CO)C1C(O)=O)C(O)=O
Show InChI InChI=1S/C7H11NO5/c8-5(7(12)13)3-2(1-9)4(3)6(10)11/h2-5,9H,1,8H2,(H,10,11)(H,12,13)/t2-,3+,4?,5+/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 6.30n/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Dissociation constant of radiolabeled compound against recombinant human Metabotropic glutamate receptor 8


Bioorg Med Chem Lett 15: 349-51 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.093
BindingDB Entry DOI: 10.7270/Q2G161M2
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50257556
PNG
(CHEMBL4101354)
Show SMILES Cc1ccc(Oc2ccc(cc2Cl)-c2ccn3c(CC4CC4)nnc3c2C(F)(F)F)c(C)n1
Show InChI InChI=1S/C24H20ClF3N4O/c1-13-3-7-19(14(2)29-13)33-20-8-6-16(12-18(20)25)17-9-10-32-21(11-15-4-5-15)30-31-23(32)22(17)24(26,27)28/h3,6-10,12,15H,4-5,11H2,1-2H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/a 7.30n/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes assessed as increase in glutamate-induced...


J Med Chem 60: 6704-6720 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50257599
PNG
(CHEMBL4100691)
Show SMILES O[C@H]1CC[C@H](CC1)Oc1ccc(cc1Cl)-c1ccn2c(CC(F)(F)F)nnc2c1Cl
Show InChI InChI=1/C20H18Cl2F3N3O2/c21-15-9-11(1-6-16(15)30-13-4-2-12(29)3-5-13)14-7-8-28-17(10-20(23,24)25)26-27-19(28)18(14)22/h1,6-9,12-13,29H,2-5,10H2/t12-,13+
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/a 8.10n/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Displacement of [3H]-JNJ46281222 from human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes after 60 mins by microbeta counting a...


J Med Chem 60: 6704-6720 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50257576
PNG
(CHEMBL4072262)
Show SMILES Fc1cc(ccc1Oc1ccnc(c1)C1CC1)-c1ccn2c(CC3CC3)nnc2c1C(F)(F)F
Show InChI InChI=1S/C25H20F4N4O/c26-19-12-16(5-6-21(19)34-17-7-9-30-20(13-17)15-3-4-15)18-8-10-33-22(11-14-1-2-14)31-32-24(33)23(18)25(27,28)29/h5-10,12-15H,1-4,11H2
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/a 8.60n/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes assessed as increase in glutamate-induced...


J Med Chem 60: 6704-6720 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50257603
PNG
(CHEMBL4076786)
Show SMILES COc1ccc(COc2ccc(cc2)-c2ccn3c(CC4CC4)nnc3c2C(F)(F)F)cn1
Show InChI InChI=1S/C24H21F3N4O2/c1-32-21-9-4-16(13-28-21)14-33-18-7-5-17(6-8-18)19-10-11-31-20(12-15-2-3-15)29-30-23(31)22(19)24(25,26)27/h4-11,13,15H,2-3,12,14H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/a 8.70n/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Binding affinity to human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes by scintillation proximity assay


J Med Chem 60: 6704-6720 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50257559
PNG
(CHEMBL4103808)
Show SMILES Cc1cc(Oc2ccc(cc2F)-c2ccn3c(CC4CC4)nnc3c2C(F)(F)F)ccn1
Show InChI InChI=1S/C23H18F4N4O/c1-13-10-16(6-8-28-13)32-19-5-4-15(12-18(19)24)17-7-9-31-20(11-14-2-3-14)29-30-22(31)21(17)23(25,26)27/h4-10,12,14H,2-3,11H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/an/a 9.20n/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes assessed as increase in glutamate-induced...


J Med Chem 60: 6704-6720 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))
BDBM50395923
PNG
(CHEMBL2164550)
Show SMILES Fc1ccc(nc1)-c1noc(n1)-c1cc(F)cc(c1)C#N
Show InChI InChI=1S/C14H6F2N4O/c15-10-1-2-12(18-7-10)13-19-14(21-20-13)9-3-8(6-17)4-11(16)5-9/h1-5,7H
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 9.40n/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Binding affinity to mGluR5 in Sprague-Dawley rat striatum after 60 mins by autoradiographic analysis


Bioorg Med Chem Lett 22: 6974-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.100
BindingDB Entry DOI: 10.7270/Q2BP03WH
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50257519
PNG
(CHEMBL4075417)
Show SMILES Cc1ccc(Oc2ccc(cc2F)-c2ccn3c(CC4CC4)nnc3c2C)c(C)n1
Show InChI InChI=1S/C24H23FN4O/c1-14-4-8-21(16(3)26-14)30-22-9-7-18(13-20(22)25)19-10-11-29-23(12-17-5-6-17)27-28-24(29)15(19)2/h4,7-11,13,17H,5-6,12H2,1-3H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/a 10n/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Binding affinity to human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes by scintillation proximity assay


J Med Chem 60: 6704-6720 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50257509
PNG
(CHEMBL4076639)
Show SMILES O[C@H]1CC[C@H](CC1)Nc1ccc(cc1Cl)-c1ccn2c(CC3CC3)nnc2c1C(F)(F)F
Show InChI InChI=1/C23H24ClF3N4O/c24-18-12-14(3-8-19(18)28-15-4-6-16(32)7-5-15)17-9-10-31-20(11-13-1-2-13)29-30-22(31)21(17)23(25,26)27/h3,8-10,12-13,15-16,28,32H,1-2,4-7,11H2/t15-,16+
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/a 10n/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Binding affinity to human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes by scintillation proximity assay


J Med Chem 60: 6704-6720 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50257604
PNG
(CHEMBL4075697)
Show SMILES CC(C)c1c(ccn2c(CC3CC3)nnc12)-c1ccc(Oc2ccc(C)nc2C)c(F)c1
Show InChI InChI=1S/C26H27FN4O/c1-15(2)25-20(11-12-31-24(13-18-6-7-18)29-30-26(25)31)19-8-10-23(21(27)14-19)32-22-9-5-16(3)28-17(22)4/h5,8-12,14-15,18H,6-7,13H2,1-4H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/a 11n/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Binding affinity to human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes by scintillation proximity assay


J Med Chem 60: 6704-6720 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50257550
PNG
(CHEMBL4075762)
Show SMILES O[C@H]1CC[C@@H](CC1)Nc1ccc(cc1Cl)-c1ccn2c(CC(F)(F)F)nnc2c1Cl
Show InChI InChI=1/C20H19Cl2F3N4O/c21-15-9-11(1-6-16(15)26-12-2-4-13(30)5-3-12)14-7-8-29-17(10-20(23,24)25)27-28-19(29)18(14)22/h1,6-9,12-13,26,30H,2-5,10H2/t12-,13-
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/a 11n/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes assessed as increase in glutamate-induced...


J Med Chem 60: 6704-6720 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50257545
PNG
(CHEMBL4067290)
Show SMILES FC(F)(F)c1c(ccn2c(CC3CC3)nnc12)-c1ccc(OC2CCOCC2)c(Cl)c1
Show InChI InChI=1S/C22H21ClF3N3O2/c23-17-12-14(3-4-18(17)31-15-6-9-30-10-7-15)16-5-8-29-19(11-13-1-2-13)27-28-21(29)20(16)22(24,25)26/h3-5,8,12-13,15H,1-2,6-7,9-11H2
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/a 12n/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Binding affinity to human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes by scintillation proximity assay


J Med Chem 60: 6704-6720 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50257601
PNG
(CHEMBL4089955)
Show SMILES Cc1cc(Oc2ccc(cc2F)-c2ccn3c(CC4CC4)nnc3c2C(F)(F)F)cc(C)n1
Show InChI InChI=1S/C24H20F4N4O/c1-13-9-17(10-14(2)29-13)33-20-6-5-16(12-19(20)25)18-7-8-32-21(11-15-3-4-15)30-31-23(32)22(18)24(26,27)28/h5-10,12,15H,3-4,11H2,1-2H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/a 12n/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Displacement of [3H]-JNJ46281222 from human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes after 60 mins by microbeta counting a...


J Med Chem 60: 6704-6720 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50257520
PNG
(CHEMBL4074421)
Show SMILES O[C@H]1CC[C@@H](CC1)Nc1ccc(cc1Cl)-c1ccn2c(CC3CC3)nnc2c1Cl
Show InChI InChI=1/C22H24Cl2N4O/c23-18-12-14(3-8-19(18)25-15-4-6-16(29)7-5-15)17-9-10-28-20(11-13-1-2-13)26-27-22(28)21(17)24/h3,8-10,12-13,15-16,25,29H,1-2,4-7,11H2/t15-,16-
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/a 13n/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Binding affinity to human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes by scintillation proximity assay


J Med Chem 60: 6704-6720 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50257594
PNG
(CHEMBL4089416)
Show SMILES Fc1cc(ccc1NC1CC1)-c1ccn2c(CC3CC3)nnc2c1Cl
Show InChI InChI=1S/C19H18ClFN4/c20-18-14(12-3-6-16(15(21)10-12)22-13-4-5-13)7-8-25-17(9-11-1-2-11)23-24-19(18)25/h3,6-8,10-11,13,22H,1-2,4-5,9H2
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/a 13n/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Binding affinity to human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes by scintillation proximity assay


J Med Chem 60: 6704-6720 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))
BDBM50318382
PNG
(3-[pyridine-2-yl)ethynyl]cyclohex-2-enone-O-fluoro...)
Show SMILES FCCOCCO\N=C1/CCCC(=C1)C#Cc1ccccn1
Show InChI InChI=1S/C17H19FN2O2/c18-9-11-21-12-13-22-20-17-6-3-4-15(14-17)7-8-16-5-1-2-10-19-16/h1-2,5,10,14H,3-4,6,9,11-13H2/b20-17+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 13.7n/an/an/an/an/a



ETH Zurich

Curated by ChEMBL


Assay Description
Binding affinity to mGluR5 ligand binding site 2 in Sprague-Dawley rat brain P2 membrane after 45 mins by gamma counting


J Med Chem 53: 4009-17 (2010)


Article DOI: 10.1021/jm901850k
BindingDB Entry DOI: 10.7270/Q2T72HMH
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50257554
PNG
(CHEMBL4075258)
Show SMILES Cc1ccc(Oc2ccc(cc2F)-c2ccn3c(CC4CC4)nnc3c2Cl)c(C)n1
Show InChI InChI=1S/C23H20ClFN4O/c1-13-3-7-19(14(2)26-13)30-20-8-6-16(12-18(20)25)17-9-10-29-21(11-15-4-5-15)27-28-23(29)22(17)24/h3,6-10,12,15H,4-5,11H2,1-2H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/a 15n/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Binding affinity to human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes by scintillation proximity assay


J Med Chem 60: 6704-6720 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50257526
PNG
(CHEMBL4072134)
Show SMILES COc1ccc(CNc2ccc(cc2)-c2ccn3c(CC4CC4)nnc3c2Cl)cn1
Show InChI InChI=1S/C23H22ClN5O/c1-30-21-9-4-16(14-26-21)13-25-18-7-5-17(6-8-18)19-10-11-29-20(12-15-2-3-15)27-28-23(29)22(19)24/h4-11,14-15,25H,2-3,12-13H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/a 16n/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Displacement of [3H]-JNJ46281222 from human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes after 60 mins by microbeta counting a...


J Med Chem 60: 6704-6720 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50257597
PNG
(CHEMBL4075537)
Show SMILES COc1ccc(COc2ccc(cc2F)-c2ccn3c(CC4CC4)nnc3c2C(F)(F)F)cn1
Show InChI InChI=1S/C24H20F4N4O2/c1-33-21-7-4-15(12-29-21)13-34-19-6-5-16(11-18(19)25)17-8-9-32-20(10-14-2-3-14)30-31-23(32)22(17)24(26,27)28/h4-9,11-12,14H,2-3,10,13H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/a 16n/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Binding affinity to human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes by scintillation proximity assay


J Med Chem 60: 6704-6720 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50257567
PNG
(CHEMBL4081244)
Show SMILES O[C@H]1CC[C@@H](CC1)Oc1ccc(cc1Cl)-c1ccn2c(CC(F)(F)F)nnc2c1Cl
Show InChI InChI=1/C20H18Cl2F3N3O2/c21-15-9-11(1-6-16(15)30-13-4-2-12(29)3-5-13)14-7-8-28-17(10-20(23,24)25)26-27-19(28)18(14)22/h1,6-9,12-13,29H,2-5,10H2/t12-,13-
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/a 17n/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes assessed as increase in glutamate-induced...


J Med Chem 60: 6704-6720 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50257600
PNG
(CHEMBL4066051)
Show SMILES Cc1ccc(Oc2ccc(cc2Cl)-c2ccn3c(CC4CC4)nnc3c2C)c(C)n1
Show InChI InChI=1S/C24H23ClN4O/c1-14-4-8-21(16(3)26-14)30-22-9-7-18(13-20(22)25)19-10-11-29-23(12-17-5-6-17)27-28-24(29)15(19)2/h4,7-11,13,17H,5-6,12H2,1-3H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/a 17n/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Binding affinity to human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes by scintillation proximity assay


J Med Chem 60: 6704-6720 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50257592
PNG
(CHEMBL4062535)
Show SMILES CC(C)Nc1ccc(cc1F)-c1ccn2c(CC3CC3)nnc2c1Cl
Show InChI InChI=1S/C19H20ClFN4/c1-11(2)22-16-6-5-13(10-15(16)21)14-7-8-25-17(9-12-3-4-12)23-24-19(25)18(14)20/h5-8,10-12,22H,3-4,9H2,1-2H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/a 20n/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Displacement of [3H]-JNJ46281222 from human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes after 60 mins by microbeta counting a...


J Med Chem 60: 6704-6720 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50257598
PNG
(CHEMBL4092275)
Show SMILES Clc1cc(ccc1NC1CCOCC1)-c1ccn2c(CC3CC3)nnc2c1Cl
Show InChI InChI=1S/C21H22Cl2N4O/c22-17-12-14(3-4-18(17)24-15-6-9-28-10-7-15)16-5-8-27-19(11-13-1-2-13)25-26-21(27)20(16)23/h3-5,8,12-13,15,24H,1-2,6-7,9-11H2
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/a 20n/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Binding affinity to human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes by scintillation proximity assay


J Med Chem 60: 6704-6720 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50257560
PNG
(CHEMBL4085882)
Show SMILES CCc1cc(Oc2ccc(cc2F)-c2ccn3c(CC4CC4)nnc3c2Cl)ccn1
Show InChI InChI=1S/C23H20ClFN4O/c1-2-16-13-17(7-9-26-16)30-20-6-5-15(12-19(20)25)18-8-10-29-21(11-14-3-4-14)27-28-23(29)22(18)24/h5-10,12-14H,2-4,11H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/an/a 23n/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes assessed as increase in glutamate-induced...


J Med Chem 60: 6704-6720 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50257521
PNG
(CHEMBL4089612)
Show SMILES CCOCc1nnc2c(Cl)c(ccn12)-c1ccc(Oc2ccc(C)nc2C)c(F)c1
Show InChI InChI=1S/C22H20ClFN4O2/c1-4-29-12-20-26-27-22-21(23)16(9-10-28(20)22)15-6-8-19(17(24)11-15)30-18-7-5-13(2)25-14(18)3/h5-11H,4,12H2,1-3H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/a 25n/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Displacement of [3H]-JNJ46281222 from human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes after 60 mins by liquid scintillation...


J Med Chem 60: 6704-6720 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50257527
PNG
(CHEMBL4088960)
Show SMILES Clc1cc(ccc1OC1CCOCC1)-c1ccn2c(CC3CC3)nnc2c1Cl
Show InChI InChI=1S/C21H21Cl2N3O2/c22-17-12-14(3-4-18(17)28-15-6-9-27-10-7-15)16-5-8-26-19(11-13-1-2-13)24-25-21(26)20(16)23/h3-5,8,12-13,15H,1-2,6-7,9-11H2
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/a 28n/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Displacement of [3H]-JNJ46281222 from human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes after 60 mins by microbeta counting a...


J Med Chem 60: 6704-6720 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50257558
PNG
(CHEMBL4093620)
Show SMILES Cc1cc(Oc2ccc(cc2F)-c2ccn3c(CC4CC4)nnc3c2Cl)ccn1
Show InChI InChI=1S/C22H18ClFN4O/c1-13-10-16(6-8-25-13)29-19-5-4-15(12-18(19)24)17-7-9-28-20(11-14-2-3-14)26-27-22(28)21(17)23/h4-10,12,14H,2-3,11H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/an/a 38n/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes assessed as increase in glutamate-induced...


J Med Chem 60: 6704-6720 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50257572
PNG
(CHEMBL4075593)
Show SMILES Fc1cc(ccc1Oc1ccnc(c1)C1CC1)-c1ccn2c(CC3CC3)nnc2c1Cl
Show InChI InChI=1S/C24H20ClFN4O/c25-23-18(8-10-30-22(11-14-1-2-14)28-29-24(23)30)16-5-6-21(19(26)12-16)31-17-7-9-27-20(13-17)15-3-4-15/h5-10,12-15H,1-4,11H2
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/a 43n/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes assessed as increase in glutamate-induced...


J Med Chem 60: 6704-6720 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50051571
PNG
(CHEMBL3337510)
Show SMILES O=c1c(C#N)c(ccn1CC1CC1)N1CCC(CC1)c1ccccc1
Show InChI InChI=1S/C21H23N3O/c22-14-19-20(10-13-24(21(19)25)15-16-6-7-16)23-11-8-18(9-12-23)17-4-2-1-3-5-17/h1-5,10,13,16,18H,6-9,11-12,15H2
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/a 51n/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Displacement of [3H]-JNJ46281222 from human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes after 60 mins by microbeta counting a...


J Med Chem 60: 6704-6720 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50257547
PNG
(CHEMBL4076286)
Show SMILES FC(F)(F)c1c(ccn2c(CC3CC3)nnc12)-c1ccc(CNC2CCOCC2)c(Cl)c1
Show InChI InChI=1S/C23H24ClF3N4O/c24-19-12-15(3-4-16(19)13-28-17-6-9-32-10-7-17)18-5-8-31-20(11-14-1-2-14)29-30-22(31)21(18)23(25,26)27/h3-5,8,12,14,17,28H,1-2,6-7,9-11,13H2
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/a 54n/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Binding affinity to human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes by scintillation proximity assay


J Med Chem 60: 6704-6720 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))
BDBM50395544
PNG
(CHEMBL2164788)
Show SMILES CCO\N=C1/C=C(CCC1F)C#Cc1ccccn1
Show InChI InChI=1/C15H15FN2O/c1-2-19-18-15-11-12(7-9-14(15)16)6-8-13-5-3-4-10-17-13/h3-5,10-11,14H,2,7,9H2,1H3/b18-15+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 70n/an/an/an/an/a



Institute of Technology (ETH) Zurich

Curated by ChEMBL


Assay Description
Binding affinity to mGluR5 receptor in Sprague-Dawley rat brain by beta counting


J Med Chem 55: 7154-62 (2012)


Article DOI: 10.1021/jm300648b
BindingDB Entry DOI: 10.7270/Q2ST7QZX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50257552
PNG
(CHEMBL4092105)
Show SMILES CC(C)C(=O)c1ccc(OCc2ccc(CNC(=O)c3cn(C)cn3)cc2)c(c1O)C(F)(F)F
Show InChI InChI=1S/C24H24F3N3O4/c1-14(2)21(31)17-8-9-19(20(22(17)32)24(25,26)27)34-12-16-6-4-15(5-7-16)10-28-23(33)18-11-30(3)13-29-18/h4-9,11,13-14,32H,10,12H2,1-3H3,(H,28,33)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/a 100n/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Binding affinity to human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes by scintillation proximity assay


J Med Chem 60: 6704-6720 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50335255
PNG
(3'-((2-cyclopentyl-6,7-dimethyl-1-oxo-2,3-dihydro-...)
Show SMILES Cc1c2C(=O)C(Cc2cc(OCc2cccc(c2)-c2ccc(cc2)C(O)=O)c1C)C1CCCC1
Show InChI InChI=1/C30H30O4/c1-18-19(2)28-25(15-26(29(28)31)22-7-3-4-8-22)16-27(18)34-17-20-6-5-9-24(14-20)21-10-12-23(13-11-21)30(32)33/h5-6,9-14,16,22,26H,3-4,7-8,15,17H2,1-2H3,(H,32,33)
PDB

UniProtKB/SwissProt

GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

PubMed
n/an/an/a 190n/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Binding affinity to human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes by scintillation proximity assay


J Med Chem 60: 6704-6720 (2017)

More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 14079 total )  |  Next  |  Last  >>
Jump to: