TargetMitogen-activated protein kinase kinase kinase 12(Homo sapiens (Human))
The University Of Texas System
US Patent
The University Of Texas System
US Patent
Affinity DataKd: 0.110nMAssay Description:The DLK dissociation constants (Kd) have been determined in the KINOMEscan KdELECT Service at DiscoveRx. A fusion protein of full length of human DLK...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 12(Homo sapiens (Human))
The University Of Texas System
US Patent
The University Of Texas System
US Patent
Affinity DataKd: 0.120nMAssay Description:A fusion protein of full length of human DLK (amino acids 1-859) and the DNA binding domain of NFkB was expressed in transiently transfected HEK293 c...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Ikena Oncology
US Patent
Ikena Oncology
US Patent
Affinity DataKd: 0.144nMAssay Description:Table 11: The experiments were performed on Biacore S200 (Cytiva). Biotinylated, unphosphorylated MEK1 was diluted to 0.1 uM by SPR buffer C (20 mM T...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 12(Homo sapiens (Human))
The University Of Texas System
US Patent
The University Of Texas System
US Patent
Affinity DataKd: 0.210nMAssay Description:A fusion protein of full length of human DLK (amino acids 1-859) and the DNA binding domain of NFkB was expressed in transiently transfected HEK293 c...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 12(Homo sapiens (Human))
The University Of Texas System
US Patent
The University Of Texas System
US Patent
Affinity DataKd: 0.240nMAssay Description:A fusion protein of full length of human DLK (amino acids 1-859) and the DNA binding domain of NFkB was expressed in transiently transfected HEK293 c...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 12(Homo sapiens (Human))
The University Of Texas System
US Patent
The University Of Texas System
US Patent
Affinity DataKd: 0.290nMAssay Description:A fusion protein of full length of human DLK (amino acids 1-859) and the DNA binding domain of NFkB was expressed in transiently transfected HEK293 c...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 12(Homo sapiens (Human))
The University Of Texas System
US Patent
The University Of Texas System
US Patent
Affinity DataKd: 0.290nMAssay Description:The DLK dissociation constants (Kd) have been determined in the KINOMEscan KdELECT Service at DiscoveRx. A fusion protein of full length of human DLK...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 12(Homo sapiens (Human))
The University Of Texas System
US Patent
The University Of Texas System
US Patent
Affinity DataKd: 0.290nMAssay Description:A fusion protein of full length of human DLK (amino acids 1-859) and the DNA binding domain of NFkB was expressed in transiently transfected HEK293 c...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 12(Homo sapiens (Human))
The University Of Texas System
US Patent
The University Of Texas System
US Patent
Affinity DataKd: 0.300nMAssay Description:A fusion protein of full length of human DLK (amino acids 1-859) and the DNA binding domain of NFkB was expressed in transiently transfected HEK293 c...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 12(Homo sapiens (Human))
The University Of Texas System
US Patent
The University Of Texas System
US Patent
Affinity DataKd: 0.310nMAssay Description:The DLK dissociation constants (Kd) have been determined in the KINOMEscan KdELECT Service at DiscoveRx. A fusion protein of full length of human DLK...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Ikena Oncology
US Patent
Ikena Oncology
US Patent
Affinity DataKd: 0.350nMAssay Description:Table 8: Exemplary MEK inhibitor compounds (0, 0.01, 0.1, or 1 μM) were added to a 384-AlphaPlate (PerkinElmer, 6008350) by a digital liquid dis...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Ikena Oncology
US Patent
Ikena Oncology
US Patent
Affinity DataKd: 0.350nMAssay Description:Table 8: Exemplary MEK inhibitor compounds (0, 0.01, 0.1, or 1 μM) were added to a 384-AlphaPlate (PerkinElmer, 6008350) by a digital liquid dis...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Ikena Oncology
US Patent
Ikena Oncology
US Patent
Affinity DataKd: 0.350nMAssay Description:Table 8: Exemplary MEK inhibitor compounds (0, 0.01, 0.1, or 1 μM) were added to a 384-AlphaPlate (PerkinElmer, 6008350) by a digital liquid dis...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 12(Homo sapiens (Human))
The University Of Texas System
US Patent
The University Of Texas System
US Patent
Affinity DataKd: 0.360nMAssay Description:The DLK dissociation constants (Kd) have been determined in the KINOMEscan KdELECT Service at DiscoveRx. A fusion protein of full length of human DLK...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 12(Homo sapiens (Human))
The University Of Texas System
US Patent
The University Of Texas System
US Patent
Affinity DataKd: 0.360nMAssay Description:A fusion protein of full length of human DLK (amino acids 1-859) and the DNA binding domain of NFkB was expressed in transiently transfected HEK293 c...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 12(Homo sapiens (Human))
The University Of Texas System
US Patent
The University Of Texas System
US Patent
Affinity DataKd: 0.360nMAssay Description:The DLK dissociation constants (Kd) have been determined in the KINOMEscan KdELECT Service at DiscoveRx. A fusion protein of full length of human DLK...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Ikena Oncology
US Patent
Ikena Oncology
US Patent
Affinity DataKd: 0.370nMAssay Description:Table 8: Exemplary MEK inhibitor compounds (0, 0.01, 0.1, or 1 μM) were added to a 384-AlphaPlate (PerkinElmer, 6008350) by a digital liquid dis...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Ikena Oncology
US Patent
Ikena Oncology
US Patent
Affinity DataKd: 0.370nMAssay Description:Table 8: Exemplary MEK inhibitor compounds (0, 0.01, 0.1, or 1 μM) were added to a 384-AlphaPlate (PerkinElmer, 6008350) by a digital liquid dis...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Ikena Oncology
US Patent
Ikena Oncology
US Patent
Affinity DataKd: 0.370nMAssay Description:Table 8: Exemplary MEK inhibitor compounds (0, 0.01, 0.1, or 1 μM) were added to a 384-AlphaPlate (PerkinElmer, 6008350) by a digital liquid dis...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Ikena Oncology
US Patent
Ikena Oncology
US Patent
Affinity DataKd: 0.380nMAssay Description:Table 8: Exemplary MEK inhibitor compounds (0, 0.01, 0.1, or 1 μM) were added to a 384-AlphaPlate (PerkinElmer, 6008350) by a digital liquid dis...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Ikena Oncology
US Patent
Ikena Oncology
US Patent
Affinity DataKd: 0.380nMAssay Description:Table 8: Exemplary MEK inhibitor compounds (0, 0.01, 0.1, or 1 μM) were added to a 384-AlphaPlate (PerkinElmer, 6008350) by a digital liquid dis...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Ikena Oncology
US Patent
Ikena Oncology
US Patent
Affinity DataKd: 0.380nMAssay Description:Table 8: Exemplary MEK inhibitor compounds (0, 0.01, 0.1, or 1 μM) were added to a 384-AlphaPlate (PerkinElmer, 6008350) by a digital liquid dis...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Ikena Oncology
US Patent
Ikena Oncology
US Patent
Affinity DataKd: 0.420nMAssay Description:Table 8: Exemplary MEK inhibitor compounds (0, 0.01, 0.1, or 1 μM) were added to a 384-AlphaPlate (PerkinElmer, 6008350) by a digital liquid dis...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Ikena Oncology
US Patent
Ikena Oncology
US Patent
Affinity DataKd: 0.420nMAssay Description:Table 8: Exemplary MEK inhibitor compounds (0, 0.01, 0.1, or 1 μM) were added to a 384-AlphaPlate (PerkinElmer, 6008350) by a digital liquid dis...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Ikena Oncology
US Patent
Ikena Oncology
US Patent
Affinity DataKd: 0.420nMAssay Description:Table 8: Exemplary MEK inhibitor compounds (0, 0.01, 0.1, or 1 μM) were added to a 384-AlphaPlate (PerkinElmer, 6008350) by a digital liquid dis...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Ikena Oncology
US Patent
Ikena Oncology
US Patent
Affinity DataKd: 0.470nMAssay Description:Table 8: Exemplary MEK inhibitor compounds (0, 0.01, 0.1, or 1 μM) were added to a 384-AlphaPlate (PerkinElmer, 6008350) by a digital liquid dis...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Ikena Oncology
US Patent
Ikena Oncology
US Patent
Affinity DataKd: 0.470nMAssay Description:Table 8: Exemplary MEK inhibitor compounds (0, 0.01, 0.1, or 1 μM) were added to a 384-AlphaPlate (PerkinElmer, 6008350) by a digital liquid dis...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Ikena Oncology
US Patent
Ikena Oncology
US Patent
Affinity DataKd: 0.470nMAssay Description:Table 8: Exemplary MEK inhibitor compounds (0, 0.01, 0.1, or 1 μM) were added to a 384-AlphaPlate (PerkinElmer, 6008350) by a digital liquid dis...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Ikena Oncology
US Patent
Ikena Oncology
US Patent
Affinity DataKd: 0.480nMAssay Description:Table 8: Exemplary MEK inhibitor compounds (0, 0.01, 0.1, or 1 μM) were added to a 384-AlphaPlate (PerkinElmer, 6008350) by a digital liquid dis...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Ikena Oncology
US Patent
Ikena Oncology
US Patent
Affinity DataKd: 0.480nMAssay Description:Table 8: Exemplary MEK inhibitor compounds (0, 0.01, 0.1, or 1 μM) were added to a 384-AlphaPlate (PerkinElmer, 6008350) by a digital liquid dis...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Ikena Oncology
US Patent
Ikena Oncology
US Patent
Affinity DataKd: 0.480nMAssay Description:Table 8: Exemplary MEK inhibitor compounds (0, 0.01, 0.1, or 1 μM) were added to a 384-AlphaPlate (PerkinElmer, 6008350) by a digital liquid dis...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 12(Homo sapiens (Human))
The University Of Texas System
US Patent
The University Of Texas System
US Patent
Affinity DataKd: 0.5nMAssay Description:A fusion protein of full length of human DLK (amino acids 1-859) and the DNA binding domain of NFkB was expressed in transiently transfected HEK293 c...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Ikena Oncology
US Patent
Ikena Oncology
US Patent
Affinity DataKd: 0.510nMAssay Description:Table 8: Exemplary MEK inhibitor compounds (0, 0.01, 0.1, or 1 μM) were added to a 384-AlphaPlate (PerkinElmer, 6008350) by a digital liquid dis...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Ikena Oncology
US Patent
Ikena Oncology
US Patent
Affinity DataKd: 0.510nMAssay Description:Table 8: Exemplary MEK inhibitor compounds (0, 0.01, 0.1, or 1 μM) were added to a 384-AlphaPlate (PerkinElmer, 6008350) by a digital liquid dis...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Ikena Oncology
US Patent
Ikena Oncology
US Patent
Affinity DataKd: 0.510nMAssay Description:Table 8: Exemplary MEK inhibitor compounds (0, 0.01, 0.1, or 1 μM) were added to a 384-AlphaPlate (PerkinElmer, 6008350) by a digital liquid dis...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Ikena Oncology
US Patent
Ikena Oncology
US Patent
Affinity DataKd: 0.510nMAssay Description:Table 8: Exemplary MEK inhibitor compounds (0, 0.01, 0.1, or 1 μM) were added to a 384-AlphaPlate (PerkinElmer, 6008350) by a digital liquid dis...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Ikena Oncology
US Patent
Ikena Oncology
US Patent
Affinity DataKd: 0.510nMAssay Description:Table 8: Exemplary MEK inhibitor compounds (0, 0.01, 0.1, or 1 μM) were added to a 384-AlphaPlate (PerkinElmer, 6008350) by a digital liquid dis...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Ikena Oncology
US Patent
Ikena Oncology
US Patent
Affinity DataKd: 0.510nMAssay Description:Table 8: Exemplary MEK inhibitor compounds (0, 0.01, 0.1, or 1 μM) were added to a 384-AlphaPlate (PerkinElmer, 6008350) by a digital liquid dis...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 19(Homo sapiens (Human))
Ambit Biosciences
Curated by ChEMBL
Ambit Biosciences
Curated by ChEMBL
Affinity DataKd: 0.520nMAssay Description:Binding affinity to YSK4More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 19(Homo sapiens (Human))
Ambit Biosciences
Curated by ChEMBL
Ambit Biosciences
Curated by ChEMBL
Affinity DataKd: 0.520nMAssay Description:Binding constant for YSK4 kinase domainMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Ikena Oncology
US Patent
Ikena Oncology
US Patent
Affinity DataKd: 0.570nMAssay Description:Table 8: Exemplary MEK inhibitor compounds (0, 0.01, 0.1, or 1 μM) were added to a 384-AlphaPlate (PerkinElmer, 6008350) by a digital liquid dis...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Ikena Oncology
US Patent
Ikena Oncology
US Patent
Affinity DataKd: 0.570nMAssay Description:Table 8: Exemplary MEK inhibitor compounds (0, 0.01, 0.1, or 1 μM) were added to a 384-AlphaPlate (PerkinElmer, 6008350) by a digital liquid dis...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Ikena Oncology
US Patent
Ikena Oncology
US Patent
Affinity DataKd: 0.570nMAssay Description:Table 8: Exemplary MEK inhibitor compounds (0, 0.01, 0.1, or 1 μM) were added to a 384-AlphaPlate (PerkinElmer, 6008350) by a digital liquid dis...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 12(Homo sapiens (Human))
The University Of Texas System
US Patent
The University Of Texas System
US Patent
Affinity DataKd: 0.620nMAssay Description:The DLK dissociation constants (Kd) have been determined in the KINOMEscan KdELECT Service at DiscoveRx. A fusion protein of full length of human DLK...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 12(Homo sapiens (Human))
The University Of Texas System
US Patent
The University Of Texas System
US Patent
Affinity DataKd: 0.620nMAssay Description:A fusion protein of full length of human DLK (amino acids 1-859) and the DNA binding domain of NFkB was expressed in transiently transfected HEK293 c...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 12(Homo sapiens (Human))
The University Of Texas System
US Patent
The University Of Texas System
US Patent
Affinity DataKd: 0.740nMAssay Description:The DLK dissociation constants (Kd) have been determined in the KINOMEscan KdELECT Service at DiscoveRx. A fusion protein of full length of human DLK...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 19(Homo sapiens (Human))
Ambit Biosciences
Curated by ChEMBL
Ambit Biosciences
Curated by ChEMBL
Affinity DataKd: 0.860nMAssay Description:Binding constant for YSK4 kinase domainMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Ikena Oncology
US Patent
Ikena Oncology
US Patent
Affinity DataKd: 1nMAssay Description:Table 8: Exemplary MEK inhibitor compounds (0, 0.01, 0.1, or 1 μM) were added to a 384-AlphaPlate (PerkinElmer, 6008350) by a digital liquid dis...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Ikena Oncology
US Patent
Ikena Oncology
US Patent
Affinity DataKd: 1nMAssay Description:Table 8: Exemplary MEK inhibitor compounds (0, 0.01, 0.1, or 1 μM) were added to a 384-AlphaPlate (PerkinElmer, 6008350) by a digital liquid dis...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Ikena Oncology
US Patent
Ikena Oncology
US Patent
Affinity DataKd: 1nMAssay Description:Table 8: Exemplary MEK inhibitor compounds (0, 0.01, 0.1, or 1 μM) were added to a 384-AlphaPlate (PerkinElmer, 6008350) by a digital liquid dis...More data for this Ligand-Target Pair