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Compile Data Set for Download or QSAR

Found 745 hits Enz. Inhib. hit(s) with Target = 'Monoglyceride Lipase (MGL)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Monoglyceride Lipase (MGL)


(Homo sapiens (human))
BDBM150300
PNG
(US8987247, 1)
Show SMILES Fc1ccc(cc1)-n1ccc2cc(ccc12)C(=O)N1CC(C1)N1CCN(CC1)C(=O)c1nccs1
Show InChI InChI=1S/C26H24FN5O2S/c27-20-2-4-21(5-3-20)32-9-7-18-15-19(1-6-23(18)32)25(33)31-16-22(17-31)29-10-12-30(13-11-29)26(34)24-28-8-14-35-24/h1-9,14-15,22H,10-13,16-17H2
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US Patent
n/an/an/a 1.40n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The ThermoFluor (TF) assay is a 384-well microplate-based binding assay that measures thermal stability of proteins1,2. The experiments were carried ...


US Patent US8987247 (2015)


BindingDB Entry DOI: 10.7270/Q2V40SXC
More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Homo sapiens (human))
BDBM50394369
PNG
(CHEMBL2159781)
Show SMILES O=C(N1CCN(CC1)C(c1ccccc1)c1ccccc1)n1nnc2ccccc12
Show InChI InChI=1S/C24H23N5O/c30-24(29-22-14-8-7-13-21(22)25-26-29)28-17-15-27(16-18-28)23(19-9-3-1-4-10-19)20-11-5-2-6-12-20/h1-14,23H,15-18H2
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75.7n/an/an/an/an/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Irreversible inhibition of human MAGL using p-nitrophenylpropionate as substrate


Bioorg Med Chem 20: 6260-75 (2012)


Article DOI: 10.1016/j.bmc.2012.09.011
BindingDB Entry DOI: 10.7270/Q2W37XDX
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM50274152
PNG
((2S,9Z)-octadec-9-ene-1,2-diamine dihydrochloride ...)
Show SMILES CCCCCCCC\C=C/CCCCCC[C@H](N)CN
Show InChI InChI=1S/C18H38N2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-18(20)17-19/h9-10,18H,2-8,11-17,19-20H2,1H3/b10-9-/t18-/m0/s1
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2.18E+4n/an/an/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat MGL


Bioorg Med Chem Lett 18: 5424-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.039
BindingDB Entry DOI: 10.7270/Q2VM4C30
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM50274153
PNG
((2R,9Z)-octadec-9-ene-1,2-diamine dihydrochloride ...)
Show SMILES CCCCCCCC\C=C/CCCCCC[C@@H](N)CN
Show InChI InChI=1S/C18H38N2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-18(20)17-19/h9-10,18H,2-8,11-17,19-20H2,1H3/b10-9-/t18-/m1/s1
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3.90E+4n/an/an/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat MGL


Bioorg Med Chem Lett 18: 5424-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.039
BindingDB Entry DOI: 10.7270/Q2VM4C30
More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Homo sapiens (human))
BDBM50379241
PNG
(CHEMBL2011479)
Show SMILES O=C(Cc1ccc(Cc2ccccc2)cc1)OC[C@H]1CO1
Show InChI InChI=1S/C18H18O3/c19-18(21-13-17-12-20-17)11-16-8-6-15(7-9-16)10-14-4-2-1-3-5-14/h1-9,17H,10-13H2/t17-/m1/s1
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4.00E+4n/an/an/an/an/an/an/an/a



Universidad Complutense de Madrid

Curated by ChEMBL


Assay Description
Non-competitive inhibition of human recombinant MAGL assessed as 7-hydroxycoumarin level using umbelliferyl arachidonate as substrate by luminescence...


J Med Chem 55: 824-36 (2012)


Article DOI: 10.1021/jm201327p
BindingDB Entry DOI: 10.7270/Q2B27W9V
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM50274151
PNG
(CHEMBL473249 | hexadecane-1,2-diamine dihydrochlor...)
Show SMILES CCCCCCCCCCCCCCC(N)CN
Show InChI InChI=1S/C16H36N2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16(18)15-17/h16H,2-15,17-18H2,1H3
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5.87E+4n/an/an/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat MGL


Bioorg Med Chem Lett 18: 5424-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.039
BindingDB Entry DOI: 10.7270/Q2VM4C30
More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Homo sapiens (human))
BDBM26123
PNG
(Phenylboronic Acid, 2 | ethyl 3-(dihydroxyboranyl)...)
Show SMILES CCOC(=O)c1cccc(c1)B(O)O
Show InChI InChI=1S/C9H11BO4/c1-2-14-9(11)7-4-3-5-8(6-7)10(12)13/h3-6,12-13H,2H2,1H3
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n/an/an/an/an/an/an/an/an/a



University of Oxford



Assay Description
The endpoint enzymatic assay was developed to quantify human recombinant MGL activity with 2-AG. The formation of arachidonic acid and depletion of ...


J Med Chem 51: 7057-60 (2008)


Article DOI: 10.1021/jm801051t
BindingDB Entry DOI: 10.7270/Q25D8Q58
More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Homo sapiens (human))
BDBM26124
PNG
(CHEMBL336239 | Phenylboronic Acid, 3 | [3-(trifluo...)
Show SMILES OB(O)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C7H6BF3O2/c9-7(10,11)5-2-1-3-6(4-5)8(12)13/h1-4,12-13H
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n/an/a 3.80E+4n/an/an/an/an/an/a



University of Oxford



Assay Description
The endpoint enzymatic assay was developed to quantify human recombinant MGL activity with 2-AG. The formation of arachidonic acid and depletion of ...


J Med Chem 51: 7057-60 (2008)


Article DOI: 10.1021/jm801051t
BindingDB Entry DOI: 10.7270/Q25D8Q58
More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Homo sapiens (human))
BDBM26125
PNG
(3-(dihydroxyboranyl)benzonitrile | Phenylboronic A...)
Show SMILES OB(O)c1cccc(c1)C#N
Show InChI InChI=1S/C7H6BNO2/c9-5-6-2-1-3-7(4-6)8(10)11/h1-4,10-11H
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n/an/an/an/an/an/an/an/an/a



University of Oxford



Assay Description
The endpoint enzymatic assay was developed to quantify human recombinant MGL activity with 2-AG. The formation of arachidonic acid and depletion of ...


J Med Chem 51: 7057-60 (2008)


Article DOI: 10.1021/jm801051t
BindingDB Entry DOI: 10.7270/Q25D8Q58
More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Homo sapiens (human))
BDBM26126
PNG
((3-phenylphenyl)boranediol | Phenylboronic Acid, 5)
Show SMILES OB(O)c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C12H11BO2/c14-13(15)12-8-4-7-11(9-12)10-5-2-1-3-6-10/h1-9,14-15H
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n/an/a 7.10E+4n/an/an/an/an/an/a



University of Oxford



Assay Description
The endpoint enzymatic assay was developed to quantify human recombinant MGL activity with 2-AG. The formation of arachidonic acid and depletion of ...


J Med Chem 51: 7057-60 (2008)


Article DOI: 10.1021/jm801051t
BindingDB Entry DOI: 10.7270/Q25D8Q58
More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Homo sapiens (human))
BDBM26127
PNG
((3-methoxyphenyl)boranediol | Phenylboronic Acid, ...)
Show SMILES COc1cccc(c1)B(O)O
Show InChI InChI=1S/C7H9BO3/c1-11-7-4-2-3-6(5-7)8(9)10/h2-5,9-10H,1H3
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n/an/an/an/an/an/an/an/an/a



University of Oxford



Assay Description
The endpoint enzymatic assay was developed to quantify human recombinant MGL activity with 2-AG. The formation of arachidonic acid and depletion of ...


J Med Chem 51: 7057-60 (2008)


Article DOI: 10.1021/jm801051t
BindingDB Entry DOI: 10.7270/Q25D8Q58
More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Homo sapiens (human))
BDBM26128
PNG
((4-fluorophenyl)boranediol | CHEMBL344890 | Phenyl...)
Show SMILES OB(O)c1ccc(F)cc1
Show InChI InChI=1S/C6H6BFO2/c8-6-3-1-5(2-4-6)7(9)10/h1-4,9-10H
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n/an/an/an/an/an/an/an/an/a



University of Oxford



Assay Description
The endpoint enzymatic assay was developed to quantify human recombinant MGL activity with 2-AG. The formation of arachidonic acid and depletion of ...


J Med Chem 51: 7057-60 (2008)


Article DOI: 10.1021/jm801051t
BindingDB Entry DOI: 10.7270/Q25D8Q58
More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Homo sapiens (human))
BDBM26129
PNG
(CHEMBL143654 | Phenylboronic Acid, 8 | [4-(trifluo...)
Show SMILES OB(O)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C7H6BF3O2/c9-7(10,11)5-1-3-6(4-2-5)8(12)13/h1-4,12-13H
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n/an/a 2.00E+4n/an/an/an/an/an/a



University of Oxford



Assay Description
The endpoint enzymatic assay was developed to quantify human recombinant MGL activity with 2-AG. The formation of arachidonic acid and depletion of ...


J Med Chem 51: 7057-60 (2008)


Article DOI: 10.1021/jm801051t
BindingDB Entry DOI: 10.7270/Q25D8Q58
More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Homo sapiens (human))
BDBM26130
PNG
((4-nitrophenyl)boranediol | Phenylboronic Acid, 9)
Show SMILES OB(O)c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C6H6BNO4/c9-7(10)5-1-3-6(4-2-5)8(11)12/h1-4,9-10H
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n/an/an/an/an/an/an/an/an/a



University of Oxford



Assay Description
The endpoint enzymatic assay was developed to quantify human recombinant MGL activity with 2-AG. The formation of arachidonic acid and depletion of ...


J Med Chem 51: 7057-60 (2008)


Article DOI: 10.1021/jm801051t
BindingDB Entry DOI: 10.7270/Q25D8Q58
More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Homo sapiens (human))
BDBM26131
PNG
(4-(dihydroxyboranyl)benzonitrile | Phenylboronic A...)
Show SMILES OB(O)c1ccc(cc1)C#N
Show InChI InChI=1S/C7H6BNO2/c9-5-6-1-3-7(4-2-6)8(10)11/h1-4,10-11H
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n/an/an/an/an/an/an/an/an/a



University of Oxford



Assay Description
The endpoint enzymatic assay was developed to quantify human recombinant MGL activity with 2-AG. The formation of arachidonic acid and depletion of ...


J Med Chem 51: 7057-60 (2008)


Article DOI: 10.1021/jm801051t
BindingDB Entry DOI: 10.7270/Q25D8Q58
More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Homo sapiens (human))
BDBM26132
PNG
((4-phenylphenyl)boranediol | Phenylboronic Acid, 1...)
Show SMILES OB(O)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C12H11BO2/c14-13(15)12-8-6-11(7-9-12)10-4-2-1-3-5-10/h1-9,14-15H
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n/an/a 1.90E+4n/an/an/an/an/an/a



University of Oxford



Assay Description
The endpoint enzymatic assay was developed to quantify human recombinant MGL activity with 2-AG. The formation of arachidonic acid and depletion of ...


J Med Chem 51: 7057-60 (2008)


Article DOI: 10.1021/jm801051t
BindingDB Entry DOI: 10.7270/Q25D8Q58
More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Homo sapiens (human))
BDBM26133
PNG
((4-methoxyphenyl)boranediol | CHEMBL21427 | Phenyl...)
Show SMILES COc1ccc(cc1)B(O)O
Show InChI InChI=1S/C7H9BO3/c1-11-7-4-2-6(3-5-7)8(9)10/h2-5,9-10H,1H3
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n/an/an/an/an/an/an/an/an/a



University of Oxford



Assay Description
The endpoint enzymatic assay was developed to quantify human recombinant MGL activity with 2-AG. The formation of arachidonic acid and depletion of ...


J Med Chem 51: 7057-60 (2008)


Article DOI: 10.1021/jm801051t
BindingDB Entry DOI: 10.7270/Q25D8Q58
More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Homo sapiens (human))
BDBM26134
PNG
((4-nonylphenyl)boranediol | Phenylboronic Acid, 13)
Show SMILES CCCCCCCCCc1ccc(cc1)B(O)O
Show InChI InChI=1S/C15H25BO2/c1-2-3-4-5-6-7-8-9-14-10-12-15(13-11-14)16(17)18/h10-13,17-18H,2-9H2,1H3
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n/an/a 7.90E+3n/an/an/an/an/an/a



University of Oxford



Assay Description
The endpoint enzymatic assay was developed to quantify human recombinant MGL activity with 2-AG. The formation of arachidonic acid and depletion of ...


J Med Chem 51: 7057-60 (2008)


Article DOI: 10.1021/jm801051t
BindingDB Entry DOI: 10.7270/Q25D8Q58
More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Homo sapiens (human))
BDBM26135
PNG
((2-fluorophenyl)boranediol | Phenylboronic Acid, 1...)
Show SMILES OB(O)c1ccccc1F
Show InChI InChI=1S/C6H6BFO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4,9-10H
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n/an/an/an/an/an/an/an/an/a



University of Oxford



Assay Description
The endpoint enzymatic assay was developed to quantify human recombinant MGL activity with 2-AG. The formation of arachidonic acid and depletion of ...


J Med Chem 51: 7057-60 (2008)


Article DOI: 10.1021/jm801051t
BindingDB Entry DOI: 10.7270/Q25D8Q58
More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Homo sapiens (human))
BDBM26136
PNG
(Phenylboronic Acid, 15 | [2-(trifluoromethyl)pheny...)
Show SMILES OB(O)c1ccccc1C(F)(F)F
Show InChI InChI=1S/C7H6BF3O2/c9-7(10,11)5-3-1-2-4-6(5)8(12)13/h1-4,12-13H
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n/an/an/an/an/an/an/an/an/a



University of Oxford



Assay Description
The endpoint enzymatic assay was developed to quantify human recombinant MGL activity with 2-AG. The formation of arachidonic acid and depletion of ...


J Med Chem 51: 7057-60 (2008)


Article DOI: 10.1021/jm801051t
BindingDB Entry DOI: 10.7270/Q25D8Q58
More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Homo sapiens (human))
BDBM26137
PNG
((2-phenylphenyl)boranediol | Phenylboronic Acid, 1...)
Show SMILES OB(O)c1ccccc1-c1ccccc1
Show InChI InChI=1S/C12H11BO2/c14-13(15)12-9-5-4-8-11(12)10-6-2-1-3-7-10/h1-9,14-15H
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n/an/an/an/an/an/an/an/an/a



University of Oxford



Assay Description
The endpoint enzymatic assay was developed to quantify human recombinant MGL activity with 2-AG. The formation of arachidonic acid and depletion of ...


J Med Chem 51: 7057-60 (2008)


Article DOI: 10.1021/jm801051t
BindingDB Entry DOI: 10.7270/Q25D8Q58
More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Homo sapiens (human))
BDBM26138
PNG
((2-methoxyphenyl)boranediol | Phenylboronic Acid, ...)
Show SMILES COc1ccccc1B(O)O
Show InChI InChI=1S/C7H9BO3/c1-11-7-5-3-2-4-6(7)8(9)10/h2-5,9-10H,1H3
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n/an/an/an/an/an/an/an/an/a



University of Oxford



Assay Description
The endpoint enzymatic assay was developed to quantify human recombinant MGL activity with 2-AG. The formation of arachidonic acid and depletion of ...


J Med Chem 51: 7057-60 (2008)


Article DOI: 10.1021/jm801051t
BindingDB Entry DOI: 10.7270/Q25D8Q58
More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Homo sapiens (human))
BDBM26139
PNG
(1-benzothiophen-2-ylboranediol | 1-benzothiophen-2...)
Show SMILES OB(O)c1cc2ccccc2s1
Show InChI InChI=1S/C8H7BO2S/c10-9(11)8-5-6-3-1-2-4-7(6)12-8/h1-5,10-11H
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n/an/a 3.20E+4n/an/an/an/an/an/a



University of Oxford



Assay Description
The endpoint enzymatic assay was developed to quantify human recombinant MGL activity with 2-AG. The formation of arachidonic acid and depletion of ...


J Med Chem 51: 7057-60 (2008)


Article DOI: 10.1021/jm801051t
BindingDB Entry DOI: 10.7270/Q25D8Q58
More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Homo sapiens (human))
BDBM26140
PNG
(1-benzofuran-2-ylboranediol | 1-benzofuran-2-ylbor...)
Show SMILES OB(O)c1cc2ccccc2o1
Show InChI InChI=1S/C8H7BO3/c10-9(11)8-5-6-3-1-2-4-7(6)12-8/h1-5,10-11H
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n/an/a 1.00E+5n/an/an/an/an/an/a



University of Oxford



Assay Description
The endpoint enzymatic assay was developed to quantify human recombinant MGL activity with 2-AG. The formation of arachidonic acid and depletion of ...


J Med Chem 51: 7057-60 (2008)


Article DOI: 10.1021/jm801051t
BindingDB Entry DOI: 10.7270/Q25D8Q58
More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Homo sapiens (human))
BDBM26141
PNG
((6-fluoropyridin-3-yl)boranediol | (6-fluoropyridi...)
Show SMILES OB(O)c1ccc(F)nc1
Show InChI InChI=1S/C5H5BFNO2/c7-5-2-1-4(3-8-5)6(9)10/h1-3,9-10H
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n/an/an/an/an/an/an/an/an/a



University of Oxford



Assay Description
The endpoint enzymatic assay was developed to quantify human recombinant MGL activity with 2-AG. The formation of arachidonic acid and depletion of ...


J Med Chem 51: 7057-60 (2008)


Article DOI: 10.1021/jm801051t
BindingDB Entry DOI: 10.7270/Q25D8Q58
More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Homo sapiens (human))
BDBM26142
PNG
((2-phenylethyl)boranediol | Alkylboronic Acid, 21)
Show SMILES OB(O)CCc1ccccc1
Show InChI InChI=1S/C8H11BO2/c10-9(11)7-6-8-4-2-1-3-5-8/h1-5,10-11H,6-7H2
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n/an/an/an/an/an/an/an/an/a



University of Oxford



Assay Description
The endpoint enzymatic assay was developed to quantify human recombinant MGL activity with 2-AG. The formation of arachidonic acid and depletion of ...


J Med Chem 51: 7057-60 (2008)


Article DOI: 10.1021/jm801051t
BindingDB Entry DOI: 10.7270/Q25D8Q58
More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Homo sapiens (human))
BDBM26143
PNG
(Alkenylboronic Acid, 22 | [(E)-2-(4-phenylphenyl)e...)
Show SMILES OB(O)\C=C\c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C14H13BO2/c16-15(17)11-10-12-6-8-14(9-7-12)13-4-2-1-3-5-13/h1-11,16-17H/b11-10+
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n/an/a 3.10E+4n/an/an/an/an/an/a



University of Oxford



Assay Description
The endpoint enzymatic assay was developed to quantify human recombinant MGL activity with 2-AG. The formation of arachidonic acid and depletion of ...


J Med Chem 51: 7057-60 (2008)


Article DOI: 10.1021/jm801051t
BindingDB Entry DOI: 10.7270/Q25D8Q58
More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Mus musculus (mouse))
BDBM26736
PNG
(CHEMBL509860 | LY2183240 | N,N-dimethyl-5-[(4-phen...)
Show SMILES CN(C)C(=O)n1nnnc1Cc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C17H17N5O/c1-21(2)17(23)22-16(18-19-20-22)12-13-8-10-15(11-9-13)14-6-4-3-5-7-14/h3-11H,12H2,1-2H3
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n/an/a 5.30n/an/an/an/a7.422



The Scripps Research Institute



Assay Description
Serine hydrolase targets were recombinantly expressed in COS-7 cells by transient transfection. IC50 values were obtained by competitive ABPP with F...


J Am Chem Soc 128: 9699-704 (2006)


Article DOI: 10.1021/ja062999h
BindingDB Entry DOI: 10.7270/Q20K26VX
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM50128581
PNG
(Biphenyl-3-yl-carbamic acid cyclohexyl ester | CHE...)
Show SMILES O=C(Nc1cccc(c1)-c1ccccc1)OC1CCCCC1
Show InChI InChI=1S/C19H21NO2/c21-19(22-18-12-5-2-6-13-18)20-17-11-7-10-16(14-17)15-8-3-1-4-9-15/h1,3-4,7-11,14,18H,2,5-6,12-13H2,(H,20,21)
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n/an/a 2.23E+5n/an/an/an/a8.0n/a



University of California, Irvine



Assay Description
The measurement of the ability of URB602 compound to inhibit MGL activity.


Chem Biol 14: 1357-65 (2007)


Article DOI: 10.1016/j.chembiol.2007.10.017
BindingDB Entry DOI: 10.7270/Q2XS5SW0
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM81311
PNG
(URB602, 3a)
Show SMILES O=C(NCCCCCc1ccccc1)OC1CCCCC1
Show InChI InChI=1S/C18H27NO2/c20-18(21-17-13-7-2-8-14-17)19-15-9-3-6-12-16-10-4-1-5-11-16/h1,4-5,10-11,17H,2-3,6-9,12-15H2,(H,19,20)
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n/an/a>3.00E+5n/an/an/an/a8.0n/a



University of California, Irvine



Assay Description
The measurement of the ability of URB602 compound to inhibit MGL activity.


Chem Biol 14: 1357-65 (2007)


Article DOI: 10.1016/j.chembiol.2007.10.017
BindingDB Entry DOI: 10.7270/Q2XS5SW0
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM81312
PNG
(URB602, 3b)
Show SMILES O=C(Nc1ccccc1)OC1CCCCC1
Show InChI InChI=1S/C13H17NO2/c15-13(14-11-7-3-1-4-8-11)16-12-9-5-2-6-10-12/h1,3-4,7-8,12H,2,5-6,9-10H2,(H,14,15)
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n/an/a>3.00E+5n/an/an/an/a8.0n/a



University of California, Irvine



Assay Description
The measurement of the ability of URB602 compound to inhibit MGL activity.


Chem Biol 14: 1357-65 (2007)


Article DOI: 10.1016/j.chembiol.2007.10.017
BindingDB Entry DOI: 10.7270/Q2XS5SW0
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM81313
PNG
(URB602, 3c)
Show SMILES O=C(Nc1cccc(c1)-c1ccccc1)OCCCCCc1ccccc1
Show InChI InChI=1S/C24H25NO2/c26-24(27-18-9-3-6-13-20-11-4-1-5-12-20)25-23-17-10-16-22(19-23)21-14-7-2-8-15-21/h1-2,4-5,7-8,10-12,14-17,19H,3,6,9,13,18H2,(H,25,26)
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n/an/a>3.00E+5n/an/an/an/a8.0n/a



University of California, Irvine



Assay Description
The measurement of the ability of URB602 compound to inhibit MGL activity.


Chem Biol 14: 1357-65 (2007)


Article DOI: 10.1016/j.chembiol.2007.10.017
BindingDB Entry DOI: 10.7270/Q2XS5SW0
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM81314
PNG
(URB602, 3d)
Show SMILES Cc1cccc(c1)-c1cccc(NC(=O)OC2CCCCC2)c1
Show InChI InChI=1S/C20H23NO2/c1-15-7-5-8-16(13-15)17-9-6-10-18(14-17)21-20(22)23-19-11-3-2-4-12-19/h5-10,13-14,19H,2-4,11-12H2,1H3,(H,21,22)
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n/an/a>3.00E+5n/an/an/an/a8.0n/a



University of California, Irvine



Assay Description
The measurement of the ability of URB602 compound to inhibit MGL activity.


Chem Biol 14: 1357-65 (2007)


Article DOI: 10.1016/j.chembiol.2007.10.017
BindingDB Entry DOI: 10.7270/Q2XS5SW0
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM81315
PNG
(URB602, 3e)
Show SMILES FC(F)(F)c1cccc(c1)-c1cccc(NC(=O)OC2CCCCC2)c1
Show InChI InChI=1S/C20H20F3NO2/c21-20(22,23)16-8-4-6-14(12-16)15-7-5-9-17(13-15)24-19(25)26-18-10-2-1-3-11-18/h4-9,12-13,18H,1-3,10-11H2,(H,24,25)
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n/an/a>3.00E+5n/an/an/an/a8.0n/a



University of California, Irvine



Assay Description
The measurement of the ability of URB602 compound to inhibit MGL activity.


Chem Biol 14: 1357-65 (2007)


Article DOI: 10.1016/j.chembiol.2007.10.017
BindingDB Entry DOI: 10.7270/Q2XS5SW0
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM81316
PNG
(URB602, 3f)
Show SMILES O=C(Nc1cccc(Oc2cccc(c2)-c2ccccc2)c1)OC1CCCCC1
Show InChI InChI=1S/C25H25NO3/c27-25(29-22-13-5-2-6-14-22)26-21-12-8-16-24(18-21)28-23-15-7-11-20(17-23)19-9-3-1-4-10-19/h1,3-4,7-12,15-18,22H,2,5-6,13-14H2,(H,26,27)
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n/an/a>3.00E+5n/an/an/an/a8.0n/a



University of California, Irvine



Assay Description
The measurement of the ability of URB602 compound to inhibit MGL activity.


Chem Biol 14: 1357-65 (2007)


Article DOI: 10.1016/j.chembiol.2007.10.017
BindingDB Entry DOI: 10.7270/Q2XS5SW0
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM81317
PNG
(URB602, 3g)
Show SMILES O=C(Nc1ccccc1-c1ccccc1)OC1CCCCC1
Show InChI InChI=1S/C19H21NO2/c21-19(22-16-11-5-2-6-12-16)20-18-14-8-7-13-17(18)15-9-3-1-4-10-15/h1,3-4,7-10,13-14,16H,2,5-6,11-12H2,(H,20,21)
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n/an/a>3.00E+5n/an/an/an/a8.0n/a



University of California, Irvine



Assay Description
The measurement of the ability of URB602 compound to inhibit MGL activity.


Chem Biol 14: 1357-65 (2007)


Article DOI: 10.1016/j.chembiol.2007.10.017
BindingDB Entry DOI: 10.7270/Q2XS5SW0
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM81318
PNG
(URB602, 3h)
Show SMILES OCC(O)COC(=O)Nc1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C16H17NO4/c18-10-15(19)11-21-16(20)17-14-8-4-7-13(9-14)12-5-2-1-3-6-12/h1-9,15,18-19H,10-11H2,(H,17,20)
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n/an/a>3.00E+5n/an/an/an/a8.0n/a



University of California, Irvine



Assay Description
The measurement of the ability of URB602 compound to inhibit MGL activity.


Chem Biol 14: 1357-65 (2007)


Article DOI: 10.1016/j.chembiol.2007.10.017
BindingDB Entry DOI: 10.7270/Q2XS5SW0
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM81319
PNG
(URB602, 3i)
Show SMILES CC1(C)OCC(CO1)OC(=O)Nc1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C19H21NO4/c1-19(2)22-12-17(13-23-19)24-18(21)20-16-10-6-9-15(11-16)14-7-4-3-5-8-14/h3-11,17H,12-13H2,1-2H3,(H,20,21)
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n/an/a>3.00E+5n/an/an/an/a8.0n/a



University of California, Irvine



Assay Description
The measurement of the ability of URB602 compound to inhibit MGL activity.


Chem Biol 14: 1357-65 (2007)


Article DOI: 10.1016/j.chembiol.2007.10.017
BindingDB Entry DOI: 10.7270/Q2XS5SW0
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM50271028
PNG
(Biphenyl-3-ylcarbamic Acid Biphenyl-3-yl Ester | C...)
Show SMILES O=C(Nc1cccc(c1)-c1ccccc1)Oc1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C25H19NO2/c27-25(26-23-15-7-13-21(17-23)19-9-3-1-4-10-19)28-24-16-8-14-22(18-24)20-11-5-2-6-12-20/h1-18H,(H,26,27)
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n/an/a>3.00E+5n/an/an/an/a8.0n/a



University of California, Irvine



Assay Description
The measurement of the ability of URB602 compound to inhibit MGL activity.


Chem Biol 14: 1357-65 (2007)


Article DOI: 10.1016/j.chembiol.2007.10.017
BindingDB Entry DOI: 10.7270/Q2XS5SW0
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM50295655
PNG
(CHEMBL541244 | URB602, 3k | cyclohexyl biphenyl-4-...)
Show SMILES O=C(Nc1ccc(cc1)-c1ccccc1)OC1CCCCC1
Show InChI InChI=1S/C19H21NO2/c21-19(22-18-9-5-2-6-10-18)20-17-13-11-16(12-14-17)15-7-3-1-4-8-15/h1,3-4,7-8,11-14,18H,2,5-6,9-10H2,(H,20,21)
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n/an/a>3.00E+5n/an/an/an/a8.0n/a



University of California, Irvine



Assay Description
The measurement of the ability of URB602 compound to inhibit MGL activity.


Chem Biol 14: 1357-65 (2007)


Article DOI: 10.1016/j.chembiol.2007.10.017
BindingDB Entry DOI: 10.7270/Q2XS5SW0
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM81320
PNG
(URB602, 3l)
Show SMILES O=C(Nc1cccc(c1)-c1ccccc1)Oc1ccccc1
Show InChI InChI=1S/C19H15NO2/c21-19(22-18-12-5-2-6-13-18)20-17-11-7-10-16(14-17)15-8-3-1-4-9-15/h1-14H,(H,20,21)
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n/an/a 2.43E+5n/an/an/an/a8.0n/a



University of California, Irvine



Assay Description
The measurement of the ability of URB602 compound to inhibit MGL activity.


Chem Biol 14: 1357-65 (2007)


Article DOI: 10.1016/j.chembiol.2007.10.017
BindingDB Entry DOI: 10.7270/Q2XS5SW0
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM81321
PNG
(URB602, 3m)
Show SMILES Cc1cccc(c1)-c1cccc(NC(=O)OC(CO)CO)c1
Show InChI InChI=1S/C17H19NO4/c1-12-4-2-5-13(8-12)14-6-3-7-15(9-14)18-17(21)22-16(10-19)11-20/h2-9,16,19-20H,10-11H2,1H3,(H,18,21)
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n/an/a>3.00E+5n/an/an/an/a8.0n/a



University of California, Irvine



Assay Description
The measurement of the ability of URB602 compound to inhibit MGL activity.


Chem Biol 14: 1357-65 (2007)


Article DOI: 10.1016/j.chembiol.2007.10.017
BindingDB Entry DOI: 10.7270/Q2XS5SW0
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM81322
PNG
(URB602, 3n)
Show SMILES OCC(CO)OC(=O)Nc1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C16H17NO4/c18-10-15(11-19)21-16(20)17-14-8-4-7-13(9-14)12-5-2-1-3-6-12/h1-9,15,18-19H,10-11H2,(H,17,20)
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n/an/a>3.00E+5n/an/an/an/a8.0n/a



University of California, Irvine



Assay Description
The measurement of the ability of URB602 compound to inhibit MGL activity.


Chem Biol 14: 1357-65 (2007)


Article DOI: 10.1016/j.chembiol.2007.10.017
BindingDB Entry DOI: 10.7270/Q2XS5SW0
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM81323
PNG
(URB602, 3o)
Show SMILES CN(C(=O)OC1CCCCC1)c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C20H23NO2/c1-21(20(22)23-19-13-6-3-7-14-19)18-12-8-11-17(15-18)16-9-4-2-5-10-16/h2,4-5,8-12,15,19H,3,6-7,13-14H2,1H3
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n/an/a>3.00E+5n/an/an/an/a8.0n/a



University of California, Irvine



Assay Description
The measurement of the ability of URB602 compound to inhibit MGL activity.


Chem Biol 14: 1357-65 (2007)


Article DOI: 10.1016/j.chembiol.2007.10.017
BindingDB Entry DOI: 10.7270/Q2XS5SW0
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM81324
PNG
(URB602, 4a)
Show SMILES O=C(NC1CCCCC1)Nc1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C19H22N2O/c22-19(20-17-11-5-2-6-12-17)21-18-13-7-10-16(14-18)15-8-3-1-4-9-15/h1,3-4,7-10,13-14,17H,2,5-6,11-12H2,(H2,20,21,22)
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n/an/a 1.15E+5n/an/an/an/a8.0n/a



University of California, Irvine



Assay Description
The measurement of the ability of URB602 compound to inhibit MGL activity.


Chem Biol 14: 1357-65 (2007)


Article DOI: 10.1016/j.chembiol.2007.10.017
BindingDB Entry DOI: 10.7270/Q2XS5SW0
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM81325
PNG
(URB602, 5)
Show SMILES O=C(CC1CCCCC1)Nc1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C20H23NO/c22-20(14-16-8-3-1-4-9-16)21-19-13-7-12-18(15-19)17-10-5-2-6-11-17/h2,5-7,10-13,15-16H,1,3-4,8-9,14H2,(H,21,22)
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n/an/a>3.00E+5n/an/an/an/a8.0n/a



University of California, Irvine



Assay Description
The measurement of the ability of URB602 compound to inhibit MGL activity.


Chem Biol 14: 1357-65 (2007)


Article DOI: 10.1016/j.chembiol.2007.10.017
BindingDB Entry DOI: 10.7270/Q2XS5SW0
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM81326
PNG
(URB602, 6)
Show SMILES O=C(Nc1cccc(c1)-c1ccccc1)SC1CCCCC1
Show InChI InChI=1S/C19H21NOS/c21-19(22-18-12-5-2-6-13-18)20-17-11-7-10-16(14-17)15-8-3-1-4-9-15/h1,3-4,7-11,14,18H,2,5-6,12-13H2,(H,20,21)
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n/an/a>3.00E+5n/an/an/an/a8.0n/a



University of California, Irvine



Assay Description
The measurement of the ability of URB602 compound to inhibit MGL activity.


Chem Biol 14: 1357-65 (2007)


Article DOI: 10.1016/j.chembiol.2007.10.017
BindingDB Entry DOI: 10.7270/Q2XS5SW0
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM81363
PNG
(Pristimerin)
Show SMILES COC(=O)[C@]1(C)CC[C@]2(C)CC[C@]3(C)C4=CC=c5c(cc(O)c(O)c5=C)[C@]4(C)CC[C@@]3(C)C2C1
Show InChI InChI=1S/C30H40O4/c1-18-19-8-9-22-28(4,20(19)16-21(31)24(18)32)13-15-30(6)23-17-27(3,25(33)34-7)11-10-26(23,2)12-14-29(22,30)5/h8-9,16,23,31-32H,1,10-15,17H2,2-7H3/t23?,26-,27-,28+,29-,30+/m1/s1
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n/an/a 93n/an/an/an/an/a37



University of California Irvine



Assay Description
Purified recombinant rat MGL was prepared and enzyme activity was assayed.


Chem Biol 16: 1045-52 (2009)


Article DOI: 10.1016/j.chembiol.2009.09.012
BindingDB Entry DOI: 10.7270/Q2HH6HJ3
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM50071058
PNG
((2R,4aS,6aS,12bR,14aS,14bR)-10-Hydroxy-2,4a,6a,9,1...)
Show SMILES C[C@]12CC[C@](C)(C[C@H]1[C@]1(C)CC[C@]3(C)C(=CC=c4c3cc(O)c(O)c4=C)[C@@]1(C)CC2)C(O)=O
Show InChI InChI=1S/C29H38O4/c1-17-18-7-8-21-27(4,19(18)15-20(30)23(17)31)12-14-29(6)22-16-26(3,24(32)33)10-9-25(22,2)11-13-28(21,29)5/h7-8,15,22,30-31H,1,9-14,16H2,2-6H3,(H,32,33)/t22-,25-,26-,27+,28-,29+/m1/s1
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n/an/a 1.60E+3n/an/an/an/an/a37



University of California Irvine



Assay Description
Purified recombinant rat MGL was prepared and enzyme activity was assayed.


Chem Biol 16: 1045-52 (2009)


Article DOI: 10.1016/j.chembiol.2009.09.012
BindingDB Entry DOI: 10.7270/Q2HH6HJ3
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM81364
PNG
(Pristimerol)
Show SMILES COC(=O)[C@]1(C)CC[C@]2(C)CC[C@]3(C)C4=CCc5c(C)c(O)c(O)cc5[C@]4(C)CC[C@@]3(C)C2C1
Show InChI InChI=1S/C30H42O4/c1-18-19-8-9-22-28(4,20(19)16-21(31)24(18)32)13-15-30(6)23-17-27(3,25(33)34-7)11-10-26(23,2)12-14-29(22,30)5/h9,16,23,31-32H,8,10-15,17H2,1-7H3/t23?,26-,27-,28+,29-,30+/m1/s1
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n/an/a 4.00E+3n/an/an/an/an/a37



University of California Irvine



Assay Description
Purified recombinant rat MGL was prepared and enzyme activity was assayed.


Chem Biol 16: 1045-52 (2009)


Article DOI: 10.1016/j.chembiol.2009.09.012
BindingDB Entry DOI: 10.7270/Q2HH6HJ3
More data for this
Ligand-Target Pair
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