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Compile Data Set for Download or QSAR

Found 247 hits Enz. Inhib. hit(s) with Target = 'Muscarinic acetylcholine receptor M3'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50443273
PNG
(CHEMBL3087240)
Show SMILES O=C(C[N+]12CCC(CC1)[C@H](C2)OC(=O)C1(CCCCCC1)C1=CC=CC1)Nc1ccon1
Show InChI InChI=1/C25H33N3O4/c29-23(26-22-11-16-31-27-22)18-28-14-9-19(10-15-28)21(17-28)32-24(30)25(20-7-3-4-8-20)12-5-1-2-6-13-25/h3-4,7,11,16,19,21H,1-2,5-6,8-10,12-15,17-18H2/p+1/t19?,21-,28?/s2
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n/an/an/a 0.0200n/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Antagonist activity at M3 receptor in Dunkin-Hartley guinea pig trachea assessed as inhibition of methacholine-induced airway smooth muscle contracti...


Bioorg Med Chem Lett 23: 6248-53 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.092
BindingDB Entry DOI: 10.7270/Q2QF8VBG
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50443275
PNG
(CHEMBL3087236)
Show SMILES NC(=O)C[N+]12CCC(CC1)[C@H](C2)OC(=O)C1(CCCCCC1)C1=CC=CC1
Show InChI InChI=1/C22H32N2O3/c23-20(25)16-24-13-9-17(10-14-24)19(15-24)27-21(26)22(18-7-3-4-8-18)11-5-1-2-6-12-22/h3-4,7,17,19H,1-2,5-6,8-16H2,(H-,23,25)/p+1/t17?,19-,24?/s2
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n/an/an/a 0.0794n/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Antagonist activity at M3 receptor in Dunkin-Hartley guinea pig trachea assessed as inhibition of methacholine-induced airway smooth muscle contracti...


Bioorg Med Chem Lett 23: 6248-53 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.092
BindingDB Entry DOI: 10.7270/Q2QF8VBG
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50443270
PNG
(CHEMBL3087368)
Show SMILES O=C(C[N+]12CCC(CC1)[C@H](C2)OC(=O)C1(CCCCCC1)C1=CC=CC1)Nc1cccnn1
Show InChI InChI=1/C26H34N4O3/c31-24(28-23-10-7-15-27-29-23)19-30-16-11-20(12-17-30)22(18-30)33-25(32)26(21-8-3-4-9-21)13-5-1-2-6-14-26/h3-4,7-8,10,15,20,22H,1-2,5-6,9,11-14,16-19H2/p+1/t20?,22-,30?/s2
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n/an/an/a 0.0794n/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Antagonist activity at M3 receptor in Dunkin-Hartley guinea pig trachea assessed as inhibition of methacholine-induced airway smooth muscle contracti...


Bioorg Med Chem Lett 23: 6248-53 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.092
BindingDB Entry DOI: 10.7270/Q2QF8VBG
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50443278
PNG
(CHEMBL3087230)
Show SMILES O=C(O[C@H]1C[N+]2(CCCc3ccncc3)CCC1CC2)C1(CCCCCC1)c1cccs1
Show InChI InChI=1/C27H37N2O2S/c30-26(27(25-8-6-20-32-25)13-3-1-2-4-14-27)31-24-21-29(18-11-23(24)12-19-29)17-5-7-22-9-15-28-16-10-22/h6,8-10,15-16,20,23-24H,1-5,7,11-14,17-19,21H2/q+1/t23?,24-,29?/s2
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n/an/an/a 0.100n/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Antagonist activity at M3 receptor in Dunkin-Hartley guinea pig trachea assessed as inhibition of methacholine-induced airway smooth muscle contracti...


Bioorg Med Chem Lett 23: 6248-53 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.092
BindingDB Entry DOI: 10.7270/Q2QF8VBG
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50443279
PNG
(CHEMBL3087229)
Show SMILES O=C(O[C@H]1C[N+]2(CCCc3ccncc3)CCC1CC2)C1(CCCCCC1)C1=CC=CC1
Show InChI InChI=1/C28H39N2O2/c31-27(28(25-9-3-4-10-25)15-5-1-2-6-16-28)32-26-22-30(20-13-24(26)14-21-30)19-7-8-23-11-17-29-18-12-23/h3-4,9,11-12,17-18,24,26H,1-2,5-8,10,13-16,19-22H2/q+1/t24?,26-,30?/s2
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AstraZeneca

Curated by ChEMBL


Assay Description
Antagonist activity at M3 receptor in Dunkin-Hartley guinea pig trachea assessed as inhibition of methacholine-induced airway smooth muscle contracti...


Bioorg Med Chem Lett 23: 6248-53 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.092
BindingDB Entry DOI: 10.7270/Q2QF8VBG
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50443269
PNG
(CHEMBL3087369)
Show SMILES O=C(C[N+]12CCC(CC1)[C@H](C2)OC(=O)C1(CCCCCC1)C1=CC=CC1)Nc1cnccn1
Show InChI InChI=1/C26H34N4O3/c31-24(29-23-17-27-13-14-28-23)19-30-15-9-20(10-16-30)22(18-30)33-25(32)26(21-7-3-4-8-21)11-5-1-2-6-12-26/h3-4,7,13-14,17,20,22H,1-2,5-6,8-12,15-16,18-19H2/p+1/t20?,22-,30?/s2
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AstraZeneca

Curated by ChEMBL


Assay Description
Antagonist activity at M3 receptor in Dunkin-Hartley guinea pig trachea assessed as inhibition of methacholine-induced airway smooth muscle contracti...


Bioorg Med Chem Lett 23: 6248-53 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.092
BindingDB Entry DOI: 10.7270/Q2QF8VBG
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50443266
PNG
(CHEMBL3087952)
Show SMILES O=C(O[C@H]1C[N+]2(Cc3nc4ccccc4o3)CCC1CC2)C1(CCCCCC1)C1=CC=CC1
Show InChI InChI=1/C28H35N2O3/c31-27(28(22-9-3-4-10-22)15-7-1-2-8-16-28)33-25-19-30(17-13-21(25)14-18-30)20-26-29-23-11-5-6-12-24(23)32-26/h3-6,9,11-12,21,25H,1-2,7-8,10,13-20H2/q+1/t21?,25-,30?/s2
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n/an/an/a 0.158n/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Antagonist activity at M3 receptor in Dunkin-Hartley guinea pig trachea assessed as inhibition of methacholine-induced airway smooth muscle contracti...


Bioorg Med Chem Lett 23: 6248-53 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.092
BindingDB Entry DOI: 10.7270/Q2QF8VBG
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50443277
PNG
(CHEMBL3087231)
Show SMILES Cc1cc(CCC[N+]23CCC(CC2)[C@H](C3)OC(=O)C2(CCCCCC2)C2=CC=CC2)ccn1
Show InChI InChI=1/C29H41N2O2/c1-23-21-24(12-17-30-23)9-8-18-31-19-13-25(14-20-31)27(22-31)33-28(32)29(26-10-4-5-11-26)15-6-2-3-7-16-29/h4-5,10,12,17,21,25,27H,2-3,6-9,11,13-16,18-20,22H2,1H3/q+1/t25?,27-,31?/s2
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n/an/an/a 0.158n/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Antagonist activity at M3 receptor in Dunkin-Hartley guinea pig trachea assessed as inhibition of methacholine-induced airway smooth muscle contracti...


Bioorg Med Chem Lett 23: 6248-53 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.092
BindingDB Entry DOI: 10.7270/Q2QF8VBG
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50443286
PNG
(CHEMBL3087958)
Show SMILES O=C(O[C@H]1C[N+]2(Cc3nnc(o3)-c3ccccc3)CCC1CC2)C1(CCCCCC1)C1=CC=CC1
Show InChI InChI=1/C29H36N3O3/c33-28(29(24-12-6-7-13-24)16-8-1-2-9-17-29)34-25-20-32(18-14-22(25)15-19-32)21-26-30-31-27(35-26)23-10-4-3-5-11-23/h3-7,10-12,22,25H,1-2,8-9,13-21H2/q+1/t22?,25-,32?/s2
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AstraZeneca

Curated by ChEMBL


Assay Description
Antagonist activity at M3 receptor in Dunkin-Hartley guinea pig trachea assessed as inhibition of methacholine-induced airway smooth muscle contracti...


Bioorg Med Chem Lett 23: 6248-53 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.092
BindingDB Entry DOI: 10.7270/Q2QF8VBG
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50443268
PNG
(CHEMBL3087946)
Show SMILES Clc1ccc(NC(=O)C[N+]23CCC(CC2)[C@H](C3)OC(=O)C2(CCCCCC2)C2=CC=CC2)nn1
Show InChI InChI=1/C26H33ClN4O3/c27-22-9-10-23(30-29-22)28-24(32)18-31-15-11-19(12-16-31)21(17-31)34-25(33)26(20-7-3-4-8-20)13-5-1-2-6-14-26/h3-4,7,9-10,19,21H,1-2,5-6,8,11-18H2/p+1/t19?,21-,31?/s2
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AstraZeneca

Curated by ChEMBL


Assay Description
Antagonist activity at M3 receptor in Dunkin-Hartley guinea pig trachea assessed as inhibition of methacholine-induced airway smooth muscle contracti...


Bioorg Med Chem Lett 23: 6248-53 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.092
BindingDB Entry DOI: 10.7270/Q2QF8VBG
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50443283
PNG
(CHEMBL3088082)
Show SMILES Clc1cccc(CC[N+]23CCC(CC2)[C@H](C3)OC(=O)C2(CCCCCC2)C2=CC=CC2)c1
Show InChI InChI=1/C28H37ClNO2/c29-25-11-7-8-22(20-25)12-17-30-18-13-23(14-19-30)26(21-30)32-27(31)28(24-9-3-4-10-24)15-5-1-2-6-16-28/h3-4,7-9,11,20,23,26H,1-2,5-6,10,12-19,21H2/q+1/t23?,26-,30?/s2
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n/an/an/a 0.251n/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Antagonist activity at M3 receptor in Dunkin-Hartley guinea pig trachea assessed as inhibition of methacholine-induced airway smooth muscle contracti...


Bioorg Med Chem Lett 23: 6248-53 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.092
BindingDB Entry DOI: 10.7270/Q2QF8VBG
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50443272
PNG
(CHEMBL3087241)
Show SMILES Cc1cc(NC(=O)C[N+]23CCC(CC2)[C@H](C3)OC(=O)C2(CCCCCC2)C2=CC=CC2)no1
Show InChI InChI=1/C26H35N3O4/c1-19-16-23(28-33-19)27-24(30)18-29-14-10-20(11-15-29)22(17-29)32-25(31)26(21-8-4-5-9-21)12-6-2-3-7-13-26/h4-5,8,16,20,22H,2-3,6-7,9-15,17-18H2,1H3/p+1/t20?,22-,29?/s2
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AstraZeneca

Curated by ChEMBL


Assay Description
Antagonist activity at M3 receptor in Dunkin-Hartley guinea pig trachea assessed as inhibition of methacholine-induced airway smooth muscle contracti...


Bioorg Med Chem Lett 23: 6248-53 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.092
BindingDB Entry DOI: 10.7270/Q2QF8VBG
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50443288
PNG
(CHEMBL3087954)
Show SMILES O=C(O[C@H]1C[N+]2(Cc3cc(no3)-c3ccccc3)CCC1CC2)C1(CCCCCC1)C1=CC=CC1
Show InChI InChI=1/C30H37N2O3/c33-29(30(25-12-6-7-13-25)16-8-1-2-9-17-30)34-28-22-32(18-14-24(28)15-19-32)21-26-20-27(31-35-26)23-10-4-3-5-11-23/h3-7,10-12,20,24,28H,1-2,8-9,13-19,21-22H2/q+1/t24?,28-,32?/s2
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n/an/an/a 0.316n/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Antagonist activity at M3 receptor in Dunkin-Hartley guinea pig trachea assessed as inhibition of methacholine-induced airway smooth muscle contracti...


Bioorg Med Chem Lett 23: 6248-53 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.092
BindingDB Entry DOI: 10.7270/Q2QF8VBG
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50443285
PNG
(CHEMBL3088080)
Show SMILES O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)C1(CCCCCC1)C1=CC=CC1
Show InChI InChI=1/C28H38NO2/c30-27(28(25-12-6-7-13-25)17-8-1-2-9-18-28)31-26-22-29(20-15-24(26)16-21-29)19-14-23-10-4-3-5-11-23/h3-7,10-12,24,26H,1-2,8-9,13-22H2/q+1/t24?,26-,29?/s2
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n/an/an/a 0.316n/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Antagonist activity at M3 receptor in Dunkin-Hartley guinea pig trachea assessed as inhibition of methacholine-induced airway smooth muscle contracti...


Bioorg Med Chem Lett 23: 6248-53 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.092
BindingDB Entry DOI: 10.7270/Q2QF8VBG
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50443284
PNG
(CHEMBL3088081)
Show SMILES Cc1ccc(CC[N+]23CCC(CC2)[C@H](C3)OC(=O)C2(CCCCCC2)C2=CC=CC2)s1
Show InChI InChI=1/C27H38NO2S/c1-21-10-11-24(31-21)14-19-28-17-12-22(13-18-28)25(20-28)30-26(29)27(23-8-4-5-9-23)15-6-2-3-7-16-27/h4-5,8,10-11,22,25H,2-3,6-7,9,12-20H2,1H3/q+1/t22?,25-,28?/s2
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AstraZeneca

Curated by ChEMBL


Assay Description
Antagonist activity at M3 receptor in Dunkin-Hartley guinea pig trachea assessed as inhibition of methacholine-induced airway smooth muscle contracti...


Bioorg Med Chem Lett 23: 6248-53 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.092
BindingDB Entry DOI: 10.7270/Q2QF8VBG
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50443271
PNG
(CHEMBL3087362)
Show SMILES O=C(C[N+]12CCC(CC1)[C@H](C2)OC(=O)C1(CCCCCC1)C1=CC=CC1)Nc1ccccn1
Show InChI InChI=1/C27H35N3O3/c31-25(29-24-11-5-8-16-28-24)20-30-17-12-21(13-18-30)23(19-30)33-26(32)27(22-9-3-4-10-22)14-6-1-2-7-15-27/h3-5,8-9,11,16,21,23H,1-2,6-7,10,12-15,17-20H2/p+1/t21?,23-,30?/s2
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n/an/an/a 0.398n/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Antagonist activity at M3 receptor in Dunkin-Hartley guinea pig trachea assessed as inhibition of methacholine-induced airway smooth muscle contracti...


Bioorg Med Chem Lett 23: 6248-53 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.092
BindingDB Entry DOI: 10.7270/Q2QF8VBG
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50443265
PNG
(CHEMBL3087953)
Show SMILES O=C(O[C@H]1C[N+]2(Cc3nc(no3)-c3ccccc3)CCC1CC2)C1(CCCCCC1)C1=CC=CC1
Show InChI InChI=1/C29H36N3O3/c33-28(29(24-12-6-7-13-24)16-8-1-2-9-17-29)34-25-20-32(18-14-22(25)15-19-32)21-26-30-27(31-35-26)23-10-4-3-5-11-23/h3-7,10-12,22,25H,1-2,8-9,13-21H2/q+1/t22?,25-,32?/s2
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AstraZeneca

Curated by ChEMBL


Assay Description
Antagonist activity at M3 receptor in Dunkin-Hartley guinea pig trachea assessed as inhibition of methacholine-induced airway smooth muscle contracti...


Bioorg Med Chem Lett 23: 6248-53 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.092
BindingDB Entry DOI: 10.7270/Q2QF8VBG
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50443282
PNG
(CHEMBL3088084)
Show SMILES O=C(O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)C1(CCCCCC1)C1=CC=CC1
Show InChI InChI=1/C28H38NO3/c30-27(28(24-10-6-7-11-24)16-8-1-2-9-17-28)32-26-22-29(18-14-23(26)15-19-29)20-21-31-25-12-4-3-5-13-25/h3-7,10,12-13,23,26H,1-2,8-9,11,14-22H2/q+1/t23?,26-,29?/s2
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n/an/an/a 0.398n/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Antagonist activity at M3 receptor in Dunkin-Hartley guinea pig trachea assessed as inhibition of methacholine-induced airway smooth muscle contracti...


Bioorg Med Chem Lett 23: 6248-53 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.092
BindingDB Entry DOI: 10.7270/Q2QF8VBG
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50443267
PNG
(CHEMBL3087949)
Show SMILES Clc1cncc(NC(=O)C[N+]23CCC(CC2)[C@H](C3)OC(=O)C2(CCCCCC2)C2=CC=CC2)n1
Show InChI InChI=1/C26H33ClN4O3/c27-22-15-28-16-23(29-22)30-24(32)18-31-13-9-19(10-14-31)21(17-31)34-25(33)26(20-7-3-4-8-20)11-5-1-2-6-12-26/h3-4,7,15-16,19,21H,1-2,5-6,8-14,17-18H2/p+1/t19?,21-,31?/s2
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n/an/an/a 0.501n/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Antagonist activity at M3 receptor in Dunkin-Hartley guinea pig trachea assessed as inhibition of methacholine-induced airway smooth muscle contracti...


Bioorg Med Chem Lett 23: 6248-53 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.092
BindingDB Entry DOI: 10.7270/Q2QF8VBG
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50241132
PNG
(3-Hydroxy-2-phenyl-propionic acid 9-methyl-3-oxa-9...)
Show SMILES C[N+]1(C)[C@H]2C[C@@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)[C@H](CO)c1ccccc1
Show InChI InChI=1/C18H24NO4/c1-19(2)14-8-12(9-15(19)17-16(14)23-17)22-18(21)13(10-20)11-6-4-3-5-7-11/h3-7,12-17,20H,8-10H2,1-2H3/q+1/t12-,13-,14-,15+,16-,17+/s2
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n/an/an/a 0.617n/an/an/an/an/a



Universita di Firenze

Curated by ChEMBL


Assay Description
Antagonist activity at muscarinic M3 receptor in guinea pig ileum assessed as effect on isotonic tension after 60 mins


J Med Chem 53: 201-7 (2010)


Article DOI: 10.1021/jm901048j
BindingDB Entry DOI: 10.7270/Q2D79CPP
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50241132
PNG
(3-Hydroxy-2-phenyl-propionic acid 9-methyl-3-oxa-9...)
Show SMILES C[N+]1(C)[C@H]2C[C@@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)[C@H](CO)c1ccccc1
Show InChI InChI=1/C18H24NO4/c1-19(2)14-8-12(9-15(19)17-16(14)23-17)22-18(21)13(10-20)11-6-4-3-5-7-11/h3-7,12-17,20H,8-10H2,1-2H3/q+1/t12-,13-,14-,15+,16-,17+/s2
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n/an/an/a 0.617n/an/an/an/an/a



Universit£ di Firenze

Curated by ChEMBL


Assay Description
Antagonist activity at muscarinic receptor M3 assessed as contraction of guinea pig ileum


J Med Chem 50: 1409-13 (2007)


Article DOI: 10.1021/jm061374r
BindingDB Entry DOI: 10.7270/Q27H1KT4
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50443276
PNG
(CHEMBL3087235)
Show SMILES O=C(O[C@H]1C[N+]2(CCCc3nc4ccccc4o3)CCC1CC2)C1(CCCCCC1)C1=CC=CC1
Show InChI InChI=1/C30H39N2O3/c33-29(30(24-10-3-4-11-24)17-7-1-2-8-18-30)35-27-22-32(20-15-23(27)16-21-32)19-9-14-28-31-25-12-5-6-13-26(25)34-28/h3-6,10,12-13,23,27H,1-2,7-9,11,14-22H2/q+1/t23?,27-,32?/s2
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n/an/an/a 0.631n/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Antagonist activity at M3 receptor in Dunkin-Hartley guinea pig trachea assessed as inhibition of methacholine-induced airway smooth muscle contracti...


Bioorg Med Chem Lett 23: 6248-53 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.092
BindingDB Entry DOI: 10.7270/Q2QF8VBG
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50176732
PNG
((R)-3-(3-methoxyquinuclidin-3-yl)-1,1-diphenylprop...)
Show SMILES CO[C@@]1(CN2CCC1CC2)C#CC(O)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C23H25NO2/c1-26-22(18-24-16-12-19(22)13-17-24)14-15-23(25,20-8-4-2-5-9-20)21-10-6-3-7-11-21/h2-11,19,25H,12-13,16-18H2,1H3/t22-/m1/s1
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n/an/an/a 0.794n/an/an/an/an/a



UCB Pharma SA

Curated by ChEMBL


Assay Description
Antagonism in muscarinic M3 receptor in guinea pig left atria


Bioorg Med Chem Lett 16: 373-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.09.079
BindingDB Entry DOI: 10.7270/Q2T72J70
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50443280
PNG
(CHEMBL3088086)
Show SMILES O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C1(CCCCCC1)C1=CC=CC1
Show InChI InChI=1/C29H40NO3/c31-28(29(25-11-6-7-12-25)17-8-1-2-9-18-29)33-27-23-30(20-15-24(27)16-21-30)19-10-22-32-26-13-4-3-5-14-26/h3-7,11,13-14,24,27H,1-2,8-10,12,15-23H2/q+1/t24?,27-,30?/s2
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n/an/an/a 0.794n/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Antagonist activity at M3 receptor in Dunkin-Hartley guinea pig trachea assessed as inhibition of methacholine-induced airway smooth muscle contracti...


Bioorg Med Chem Lett 23: 6248-53 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.092
BindingDB Entry DOI: 10.7270/Q2QF8VBG
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50176708
PNG
((R)-3-((R)-3-methoxyquinuclidin-3-yl)-1-phenyl-1-(...)
Show SMILES CO[C@@]1(CN2CCC1CC2)C#C[C@@](O)(c1ccccc1)c1cccnc1
Show InChI InChI=1S/C22H24N2O2/c1-26-21(17-24-14-9-18(21)10-15-24)11-12-22(25,19-6-3-2-4-7-19)20-8-5-13-23-16-20/h2-8,13,16,18,25H,9-10,14-15,17H2,1H3/t21-,22-/m1/s1
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n/an/an/a 1.30n/an/an/an/an/a



UCB Pharma SA

Curated by ChEMBL


Assay Description
Antagonism in muscarinic M3 receptor in guinea pig left atria


Bioorg Med Chem Lett 16: 373-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.09.079
BindingDB Entry DOI: 10.7270/Q2T72J70
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50403547
PNG
(ATROPEN | ATROPINE)
Show SMILES CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)C(CO)c1ccccc1
Show InChI InChI=1/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3/t13-,14+,15+,16?
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n/an/an/a 1.5n/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Antagonist potency against carbachol induced contractions of isolated guinea pig ileum Muscarinic acetylcholine receptor


J Med Chem 32: 79-84 (1989)


Article DOI: 10.1021/jm00121a017
BindingDB Entry DOI: 10.7270/Q2N017RN
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50176710
PNG
((S)-1-cyclohexyl-3-((R)-3-methoxyquinuclidin-3-yl)...)
Show SMILES CO[C@@]1(CN2CCC1CC2)C#C[C@](O)(C1CCCCC1)c1ccccc1
Show InChI InChI=1S/C23H31NO2/c1-26-22(18-24-16-12-19(22)13-17-24)14-15-23(25,20-8-4-2-5-9-20)21-10-6-3-7-11-21/h2,4-5,8-9,19,21,25H,3,6-7,10-13,16-18H2,1H3/t22-,23-/m1/s1
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n/an/an/a 1.60n/an/an/an/an/a



UCB Pharma SA

Curated by ChEMBL


Assay Description
Antagonism in muscarinic M3 receptor in guinea pig left atria


Bioorg Med Chem Lett 16: 373-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.09.079
BindingDB Entry DOI: 10.7270/Q2T72J70
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50176723
PNG
((R)-3-(3-methoxyquinuclidin-3-yl)-1,1-di(thiophen-...)
Show SMILES CO[C@@]1(CN2CCC1CC2)C#CC(O)(c1cccs1)c1cccs1
Show InChI InChI=1S/C19H21NO2S2/c1-22-18(14-20-10-6-15(18)7-11-20)8-9-19(21,16-4-2-12-23-16)17-5-3-13-24-17/h2-5,12-13,15,21H,6-7,10-11,14H2,1H3/t18-/m1/s1
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n/an/an/a 2.5n/an/an/an/an/a



UCB Pharma SA

Curated by ChEMBL


Assay Description
Antagonism in muscarinic M3 receptor in guinea pig left atria


Bioorg Med Chem Lett 16: 373-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.09.079
BindingDB Entry DOI: 10.7270/Q2T72J70
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50176726
PNG
(1-(2-fluoropyridin-3-yl)-3-(3-methoxyquinuclidin-3...)
Show SMILES COC1(CN2CCC1CC2)C#CC(O)(c1ccccc1)c1cccnc1F
Show InChI InChI=1/C22H23FN2O2/c1-27-21(16-25-14-9-17(21)10-15-25)11-12-22(26,18-6-3-2-4-7-18)19-8-5-13-24-20(19)23/h2-8,13,17,26H,9-10,14-16H2,1H3
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n/an/an/a 2.5n/an/an/an/an/a



UCB Pharma SA

Curated by ChEMBL


Assay Description
Antagonism in muscarinic M3 receptor in guinea pig left atria


Bioorg Med Chem Lett 16: 373-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.09.079
BindingDB Entry DOI: 10.7270/Q2T72J70
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50443287
PNG
(CHEMBL3087957)
Show SMILES O=C(O[C@H]1C[N+]2(Cc3cc(on3)-c3ccccc3)CCC1CC2)C1(CCCCCC1)C1=CC=CC1
Show InChI InChI=1/C30H37N2O3/c33-29(30(25-12-6-7-13-25)16-8-1-2-9-17-30)34-28-22-32(18-14-24(28)15-19-32)21-26-20-27(35-31-26)23-10-4-3-5-11-23/h3-7,10-12,20,24,28H,1-2,8-9,13-19,21-22H2/q+1/t24?,28-,32?/s2
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n/an/an/a 3.20n/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Antagonist activity at M3 receptor in Dunkin-Hartley guinea pig trachea assessed as inhibition of methacholine-induced airway smooth muscle contracti...


Bioorg Med Chem Lett 23: 6248-53 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.092
BindingDB Entry DOI: 10.7270/Q2QF8VBG
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50443274
PNG
(CHEMBL3087238)
Show SMILES Fc1cccc(NC(=O)C[N+]23CCC(CC2)[C@H](C3)OC(=O)C2(CCCCCC2)C2=CC=CC2)c1
Show InChI InChI=1/C28H35FN2O3/c29-23-10-7-11-24(18-23)30-26(32)20-31-16-12-21(13-17-31)25(19-31)34-27(33)28(22-8-3-4-9-22)14-5-1-2-6-15-28/h3-4,7-8,10-11,18,21,25H,1-2,5-6,9,12-17,19-20H2/p+1/t21?,25-,31?/s2
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n/an/an/a 3.20n/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Antagonist activity at M3 receptor in Dunkin-Hartley guinea pig trachea assessed as inhibition of methacholine-induced airway smooth muscle contracti...


Bioorg Med Chem Lett 23: 6248-53 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.092
BindingDB Entry DOI: 10.7270/Q2QF8VBG
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50443281
PNG
(CHEMBL3088085)
Show SMILES O=C(O[C@H]1C[N+]2(CCOCc3ccccc3)CCC1CC2)C1(CCCCCC1)C1=CC=CC1
Show InChI InChI=1/C29H40NO3/c31-28(29(26-12-6-7-13-26)16-8-1-2-9-17-29)33-27-22-30(18-14-25(27)15-19-30)20-21-32-23-24-10-4-3-5-11-24/h3-7,10-12,25,27H,1-2,8-9,13-23H2/q+1/t25?,27-,30?/s2
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n/an/an/a 4n/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Antagonist activity at M3 receptor in Dunkin-Hartley guinea pig trachea assessed as inhibition of methacholine-induced airway smooth muscle contracti...


Bioorg Med Chem Lett 23: 6248-53 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.092
BindingDB Entry DOI: 10.7270/Q2QF8VBG
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50176716
PNG
(3-(3-methoxyquinuclidin-3-yl)-1-phenyl-1-(pyridin-...)
Show SMILES COC1(CN2CCC1CC2)C#CC(O)(c1ccccc1)c1ccncc1
Show InChI InChI=1/C22H24N2O2/c1-26-21(17-24-15-9-18(21)10-16-24)11-12-22(25,19-5-3-2-4-6-19)20-7-13-23-14-8-20/h2-8,13-14,18,25H,9-10,15-17H2,1H3
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n/an/an/a 4n/an/an/an/an/a



UCB Pharma SA

Curated by ChEMBL


Assay Description
Antagonism in muscarinic M3 receptor in guinea pig left atria


Bioorg Med Chem Lett 16: 373-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.09.079
BindingDB Entry DOI: 10.7270/Q2T72J70
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50411965
PNG
(CHEMBL264676)
Show SMILES CO[C@@]1(CN2CCC1CC2)C#C[C@@](O)(C1CCCCCCC1)c1ccccc1
Show InChI InChI=1S/C25H35NO2/c1-28-24(20-26-18-14-21(24)15-19-26)16-17-25(27,23-12-8-5-9-13-23)22-10-6-3-2-4-7-11-22/h5,8-9,12-13,21-22,27H,2-4,6-7,10-11,14-15,18-20H2,1H3/t24-,25-/m1/s1
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n/an/an/a 6.31n/an/an/an/an/a



UCB Pharma SA

Curated by ChEMBL


Assay Description
Antagonist activity at muscarinic M3 receptor in carbachol-stimulated guinea pig trachea


Bioorg Med Chem Lett 18: 2675-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.024
BindingDB Entry DOI: 10.7270/Q2KK9D04
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50411964
PNG
(CHEMBL409151)
Show SMILES CO[C@@]1(CN2CCC1CC2)C#C[C@@](O)(C1CCCCCC1)c1ccccc1
Show InChI InChI=1S/C24H33NO2/c1-27-23(19-25-17-13-20(23)14-18-25)15-16-24(26,22-11-7-4-8-12-22)21-9-5-2-3-6-10-21/h4,7-8,11-12,20-21,26H,2-3,5-6,9-10,13-14,17-19H2,1H3/t23-,24-/m1/s1
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n/an/an/a 6.31n/an/an/an/an/a



UCB Pharma SA

Curated by ChEMBL


Assay Description
Antagonist activity at muscarinic M3 receptor in carbachol-stimulated guinea pig trachea


Bioorg Med Chem Lett 18: 2675-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.024
BindingDB Entry DOI: 10.7270/Q2KK9D04
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50176714
PNG
(1-cyclobutyl-3-(3-methoxyquinuclidin-3-yl)-1-pheny...)
Show SMILES COC1(CN2CCC1CC2)C#CC(O)(C1CCC1)c1ccccc1
Show InChI InChI=1/C21H27NO2/c1-24-20(16-22-14-10-17(20)11-15-22)12-13-21(23,19-8-5-9-19)18-6-3-2-4-7-18/h2-4,6-7,17,19,23H,5,8-11,14-16H2,1H3
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n/an/an/a 10n/an/an/an/an/a



UCB Pharma SA

Curated by ChEMBL


Assay Description
Antagonism in muscarinic M3 receptor in guinea pig left atria


Bioorg Med Chem Lett 16: 373-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.09.079
BindingDB Entry DOI: 10.7270/Q2T72J70
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50181089
PNG
(6-(azepan-1-yl)-N,2-dicyclopropyl-5-methylpyrimidi...)
Show SMILES Cc1c(NC2CC2)nc(nc1N1CCCCCC1)C1CC1
Show InChI InChI=1S/C17H26N4/c1-12-15(18-14-8-9-14)19-16(13-6-7-13)20-17(12)21-10-4-2-3-5-11-21/h13-14H,2-11H2,1H3,(H,18,19,20)
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n/an/an/a 12.6n/an/an/an/an/a



UCB Pharma SA

Curated by ChEMBL


Assay Description
Activity at M3 muscarinic receptor in guinea pig assessed as effect on carbachol-induced trachea contraction


Bioorg Med Chem Lett 17: 3077-80 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.047
BindingDB Entry DOI: 10.7270/Q2PR7VNX
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50181089
PNG
(6-(azepan-1-yl)-N,2-dicyclopropyl-5-methylpyrimidi...)
Show SMILES Cc1c(NC2CC2)nc(nc1N1CCCCCC1)C1CC1
Show InChI InChI=1S/C17H26N4/c1-12-15(18-14-8-9-14)19-16(13-6-7-13)20-17(12)21-10-4-2-3-5-11-21/h13-14H,2-11H2,1H3,(H,18,19,20)
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n/an/an/a 13n/an/an/an/an/a



UCB Pharma SA

Curated by ChEMBL


Assay Description
Activity at muscarinic M3 receptor in guinea pig trachea contracted with carbachol


Bioorg Med Chem Lett 16: 1834-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.006
BindingDB Entry DOI: 10.7270/Q2TQ613B
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50165008
PNG
((+)-(R)-2-(alpha-(2-(Diisopropylamino)ethyl)benzyl...)
Show SMILES CC(C)N(CC[C@H](c1ccccc1)c1cc(C)ccc1O)C(C)C
Show InChI InChI=1S/C22H31NO/c1-16(2)23(17(3)4)14-13-20(19-9-7-6-8-10-19)21-15-18(5)11-12-22(21)24/h6-12,15-17,20,24H,13-14H2,1-5H3/t20-/m1/s1
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n/an/an/a 20n/an/an/an/an/a



UCB Pharma SA

Curated by ChEMBL


Assay Description
Antagonism in muscarinic M3 receptor in guinea pig left atria


Bioorg Med Chem Lett 16: 373-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.09.079
BindingDB Entry DOI: 10.7270/Q2T72J70
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50176715
PNG
(3-(3-methoxyquinuclidin-3-yl)-1-phenyl-1-(pyridin-...)
Show SMILES COC1(CN2CCC1CC2)C#CC(O)(c1ccccc1)c1ccccn1
Show InChI InChI=1/C22H24N2O2/c1-26-21(17-24-15-10-18(21)11-16-24)12-13-22(25,19-7-3-2-4-8-19)20-9-5-6-14-23-20/h2-9,14,18,25H,10-11,15-17H2,1H3
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n/an/an/a 32n/an/an/an/an/a



UCB Pharma SA

Curated by ChEMBL


Assay Description
Antagonism in muscarinic M3 receptor in guinea pig left atria


Bioorg Med Chem Lett 16: 373-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.09.079
BindingDB Entry DOI: 10.7270/Q2T72J70
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50109647
PNG
(2-{1-[2-(2,3-Dihydro-benzofuran-5-yl)-ethyl]-pyrro...)
Show SMILES NC(=O)C([C@@H]1CCN(CCc2ccc3OCCc3c2)C1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C28H30N2O2/c29-27(31)28(23-7-3-1-4-8-23,24-9-5-2-6-10-24)25-14-17-30(20-25)16-13-21-11-12-26-22(19-21)15-18-32-26/h1-12,19,25H,13-18,20H2,(H2,29,31)/t25-/m1/s1
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n/an/an/a 50n/an/an/an/an/a



UCB Pharma SA

Curated by ChEMBL


Assay Description
Antagonism in muscarinic M3 receptor in guinea pig left atria


Bioorg Med Chem Lett 16: 373-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.09.079
BindingDB Entry DOI: 10.7270/Q2T72J70
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50151858
PNG
(4-(diethylamino)but-2-yn-1-yl (2S)-cyclohexyl(hydr...)
Show SMILES CCN(CC)CC#CCOC(=O)[C@@](O)(C1CCCCC1)c1ccccc1
Show InChI InChI=1S/C22H31NO3/c1-3-23(4-2)17-11-12-18-26-21(24)22(25,19-13-7-5-8-14-19)20-15-9-6-10-16-20/h5,7-8,13-14,20,25H,3-4,6,9-10,15-18H2,1-2H3/t22-/m0/s1
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n/an/an/a 79n/an/an/an/an/a



UCB Pharma SA

Curated by ChEMBL


Assay Description
Antagonism in muscarinic M3 receptor in guinea pig left atria


Bioorg Med Chem Lett 16: 373-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.09.079
BindingDB Entry DOI: 10.7270/Q2T72J70
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50004726
PNG
(1-(1-Methyl-4-pyrrolidin-1-yl-but-2-ynyl)-pyrrolid...)
Show SMILES CC(C#CCN1CCCC1)N1CCCC1=O
Show InChI InChI=1/C13H20N2O/c1-12(15-11-5-7-13(15)16)6-4-10-14-8-2-3-9-14/h12H,2-3,5,7-11H2,1H3
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n/an/an/a 91n/an/an/an/an/a



University of Uppsala

Curated by ChEMBL


Assay Description
Dissociation constant for complex with muscarinic acetylcholine receptor M3 of guinea pig ileum


J Med Chem 35: 3270-9 (1992)


Article DOI: 10.1021/jm00095a025
BindingDB Entry DOI: 10.7270/Q2KP813K
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM81900
PNG
(AQ-RA 741 | CAS_129989 | NSC_129989)
Show SMILES CCN(CC)CCCCC1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C27H37N5O2/c1-3-30(4-2)17-8-7-10-21-14-18-31(19-15-21)20-25(33)32-24-13-6-5-11-22(24)27(34)29-23-12-9-16-28-26(23)32/h5-6,9,11-13,16,21H,3-4,7-8,10,14-15,17-20H2,1-2H3,(H,29,34)
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n/an/an/a 100n/an/an/an/an/a



University of Bologna

Curated by ChEMBL


Assay Description
Antagonistic activity against M3 muscarinic receptor in guinea pig left ileum derived by plotting log(DR - 1) vs log[antagonist]


J Med Chem 37: 3363-72 (1994)


Article DOI: 10.1021/jm00046a021
BindingDB Entry DOI: 10.7270/Q21V5G5G
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50407225
PNG
(CHEMBL442014)
Show SMILES CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc12)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C50H68N10O4/c1-57(35-19-9-5-15-29-51-37-45(61)59-43-27-13-11-23-39(43)49(63)55-41-25-21-31-53-47(41)59)33-17-7-3-4-8-18-34-58(2)36-20-10-6-16-30-52-38-46(62)60-44-28-14-12-24-40(44)50(64)56-42-26-22-32-54-48(42)60/h11-14,21-28,31-32,51-52H,3-10,15-20,29-30,33-38H2,1-2H3,(H,55,63)(H,56,64)
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n/an/an/a 126n/an/an/an/an/a



University of Bologna

Curated by ChEMBL


Assay Description
Antagonistic activity against M3 muscarinic receptor in guinea pig left ileum derived by plotting log(DR - 1) vs log[antagonist]


J Med Chem 37: 3363-72 (1994)


Article DOI: 10.1021/jm00046a021
BindingDB Entry DOI: 10.7270/Q21V5G5G
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50408719
PNG
(CHEMBL107779)
Show SMILES CCN(CC)CCOc1ccccc1C(=O)Cc1ccccc1
Show InChI InChI=1S/C20H25NO2/c1-3-21(4-2)14-15-23-20-13-9-8-12-18(20)19(22)16-17-10-6-5-7-11-17/h5-13H,3-4,14-16H2,1-2H3
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n/an/an/a 214n/an/an/an/an/a



Astra Charnwood

Curated by ChEMBL


Assay Description
The compound was tested for antagonistic activity against Muscarinic acetylcholine receptor M3 in guinea pig trachea


J Med Chem 42: 3210-6 (1999)


Article DOI: 10.1021/jm980409n
BindingDB Entry DOI: 10.7270/Q2P84D4V
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50004734
PNG
(CHEMBL310852 | N-Methyl-N-(1-methyl-4-pyrrolidin-1...)
Show SMILES CC(C#CCN1CCCC1)N(C)C(C)=O
Show InChI InChI=1/C12H20N2O/c1-11(13(3)12(2)15)7-6-10-14-8-4-5-9-14/h11H,4-5,8-10H2,1-3H3
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n/an/an/a 240n/an/an/an/an/a



University of Uppsala

Curated by ChEMBL


Assay Description
Dissociation constant for complex with muscarinic acetylcholine receptor M3 of guinea pig ileum


J Med Chem 35: 3270-9 (1992)


Article DOI: 10.1021/jm00095a025
BindingDB Entry DOI: 10.7270/Q2KP813K
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM82423
PNG
(CAS_132947 | NSC_132947 | TRIPITRAMINE)
Show SMILES CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc12)CC(=O)N1c2ccccc2C(=O)Nc2cccnc12)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C64H77N13O6/c1-72(41-20-8-5-17-35-65-44-56(78)75-53-32-14-11-26-47(53)62(81)69-50-29-23-36-66-59(50)75)39-18-6-3-4-7-19-40-73(2)42-21-9-10-22-43-74(45-57(79)76-54-33-15-12-27-48(54)63(82)70-51-30-24-37-67-60(51)76)46-58(80)77-55-34-16-13-28-49(55)64(83)71-52-31-25-38-68-61(52)77/h11-16,23-34,36-38,65H,3-10,17-22,35,39-46H2,1-2H3,(H,69,81)(H,70,82)(H,71,83)
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n/an/an/a 282n/an/an/an/an/a



University of Bologna

Curated by ChEMBL


Assay Description
Antagonistic activity against M3 muscarinic receptor in guinea pig left ileum derived by plotting log(DR - 1) vs log[antagonist]


J Med Chem 37: 3363-72 (1994)


Article DOI: 10.1021/jm00046a021
BindingDB Entry DOI: 10.7270/Q21V5G5G
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50223176
PNG
(1-[4-(4,5-dihydroisoxazol-3-yloxy)but-2-yn-1-yl]pi...)
Show SMILES C[N+]1(CC#CCOC2=NOCC2)CCCCC1
Show InChI InChI=1S/C13H21N2O2/c1-15(8-3-2-4-9-15)10-5-6-11-16-13-7-12-17-14-13/h2-4,7-12H2,1H3/q+1
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n/an/an/a 295n/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Binding affinity to muscarinic M3 receptor in guinea-pig ileum


Bioorg Med Chem 15: 7626-37 (2007)


Article DOI: 10.1016/j.bmc.2007.09.003
BindingDB Entry DOI: 10.7270/Q29K4C27
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50422740
PNG
(CHEMBL199636)
Show SMILES CC(C)(CN1C(=O)c2cccc3cccc(C1=O)c23)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCN1CCCC1=O
Show InChI InChI=1S/C35H50N4O3/c1-35(2,26-37-33(41)29-18-13-16-28-17-14-19-30(32(28)29)34(37)42)27-39(5,6)25-11-8-7-10-23-38(3,4)24-12-9-21-36-22-15-20-31(36)40/h13-14,16-19H,7-8,10-11,15,20-27H2,1-6H3/q+2
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n/an/an/a 355n/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Potency at muscarinic receptor M3 in guinea pig ileum


J Med Chem 49: 366-72 (2006)


Article DOI: 10.1021/jm050769s
BindingDB Entry DOI: 10.7270/Q2DV1M6G
More data for this
Ligand-Target Pair
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