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Compile Data Set for Download or QSAR

Found 25 hits Enz. Inhib. hit(s) with Target = 'Myc proto-oncogene protein'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Myc proto-oncogene protein


(Homo sapiens (Human))
BDBM50463126
PNG
(CHEMBL4238599)
Show SMILES NC(=O)c1ccc(cc1)-c1cc(nc(c1)-c1ccc(cc1)[N+]([O-])=O)-c1ccco1
Show InChI InChI=1S/C22H15N3O4/c23-22(26)16-5-3-14(4-6-16)17-12-19(15-7-9-18(10-8-15)25(27)28)24-20(13-17)21-2-1-11-29-21/h1-13H,(H2,23,26)
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n/an/an/a 6.5n/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to His-tagged Myc (unknown origin) expressed in Escherichia coli BL21 by Bio-FET analysis


Bioorg Med Chem 26: 4234-4239 (2018)

More data for this
Ligand-Target Pair
Myc proto-oncogene protein


(Homo sapiens (Human))
BDBM50463128
PNG
(CHEMBL4249055)
Show SMILES NC(=O)c1ccc(cc1)-c1cc(nc(c1)-c1ccc(cc1)-c1nccs1)-c1ccco1
Show InChI InChI=1S/C25H17N3O2S/c26-24(29)18-7-3-16(4-8-18)20-14-21(28-22(15-20)23-2-1-12-30-23)17-5-9-19(10-6-17)25-27-11-13-31-25/h1-15H,(H2,26,29)
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n/an/an/a 13n/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to His-tagged Myc (unknown origin) expressed in Escherichia coli BL21 by Bio-FET analysis


Bioorg Med Chem 26: 4234-4239 (2018)

More data for this
Ligand-Target Pair
Myc proto-oncogene protein


(Homo sapiens (Human))
BDBM50423921
PNG
(CHEMBL2312756)
Show SMILES [O-][N+](=O)c1ccc(Nc2ccccc2-c2ccccc2)c2nonc12
Show InChI InChI=1S/C18H12N4O3/c23-22(24)16-11-10-15(17-18(16)21-25-20-17)19-14-9-5-4-8-13(14)12-6-2-1-3-7-12/h1-11,19H
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PC cid
PC sid
UniChem
Article
PubMed
n/an/an/a 2.80E+3n/an/an/an/an/a



University of Maryland

Curated by ChEMBL


Assay Description
Binding affinity to human c-Myc bHLH-ZIP domain (353 to 437 amino acid residues) expressed in Escherichia coli BL21 (DE3) by fluorescence polarizatio...


Bioorg Med Chem Lett 23: 370-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.013
BindingDB Entry DOI: 10.7270/Q2WM1FPM
More data for this
Ligand-Target Pair
Myc proto-oncogene protein


(Homo sapiens (Human))
BDBM50463124
PNG
(CHEMBL4248050)
Show SMILES COc1ccc(cc1)-c1cc(nc(n1)-c1ccccc1)-c1ccc(cc1)C(N)=O
Show InChI InChI=1S/C24H19N3O2/c1-29-20-13-11-17(12-14-20)22-15-21(16-7-9-18(10-8-16)23(25)28)26-24(27-22)19-5-3-2-4-6-19/h2-15H,1H3,(H2,25,28)
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n/an/a>1.00E+5n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to ATG-Myc (unknown origin) expressed in CEF cells assessed as inhibition of microtumor formation


Bioorg Med Chem 26: 4234-4239 (2018)

More data for this
Ligand-Target Pair
Myc proto-oncogene protein


(Homo sapiens (Human))
BDBM50463125
PNG
(CHEMBL4242611)
Show SMILES NC(=O)c1ccc(cc1)-c1cc(nc(n1)-c1cc[n+]([O-])cc1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C23H15N5O2/c24-14-15-1-3-16(4-2-15)20-13-21(17-5-7-18(8-6-17)22(25)29)27-23(26-20)19-9-11-28(30)12-10-19/h1-13H,(H2,25,29)
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n/an/a>1.00E+5n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to ATG-Myc (unknown origin) expressed in CEF cells assessed as inhibition of microtumor formation


Bioorg Med Chem 26: 4234-4239 (2018)

More data for this
Ligand-Target Pair
Myc proto-oncogene protein


(Homo sapiens (Human))
BDBM50463126
PNG
(CHEMBL4238599)
Show SMILES NC(=O)c1ccc(cc1)-c1cc(nc(c1)-c1ccc(cc1)[N+]([O-])=O)-c1ccco1
Show InChI InChI=1S/C22H15N3O4/c23-22(26)16-5-3-14(4-6-16)17-12-19(15-7-9-18(10-8-15)25(27)28)24-20(13-17)21-2-1-11-29-21/h1-13H,(H2,23,26)
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n/an/a 1.00E+3n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to ATG-Myc (unknown origin) expressed in CEF cells assessed as inhibition of microtumor formation


Bioorg Med Chem 26: 4234-4239 (2018)

More data for this
Ligand-Target Pair
Myc proto-oncogene protein


(Homo sapiens (Human))
BDBM50463127
PNG
(CHEMBL4237402)
Show SMILES NC(=O)c1ccc(cc1)-c1cc(nc(c1)-c1ccc(cc1)-c1cnco1)-c1ccco1
Show InChI InChI=1S/C25H17N3O3/c26-25(29)19-9-3-16(4-10-19)20-12-21(28-22(13-20)23-2-1-11-30-23)17-5-7-18(8-6-17)24-14-27-15-31-24/h1-15H,(H2,26,29)
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n/an/a 2.50E+3n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to ATG-Myc (unknown origin) expressed in CEF cells assessed as inhibition of microtumor formation


Bioorg Med Chem 26: 4234-4239 (2018)

More data for this
Ligand-Target Pair
Myc proto-oncogene protein


(Homo sapiens (Human))
BDBM50463129
PNG
(CHEMBL4245253)
Show SMILES Cn1ccnc1-c1cc(cc(n1)-c1ccc(cc1)C#N)-c1ccc(cc1)C(N)=O
Show InChI InChI=1S/C23H17N5O/c1-28-11-10-26-23(28)21-13-19(16-6-8-18(9-7-16)22(25)29)12-20(27-21)17-4-2-15(14-24)3-5-17/h2-13H,1H3,(H2,25,29)
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n/an/a 4.00E+4n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to ATG-Myc (unknown origin) expressed in CEF cells assessed as inhibition of microtumor formation


Bioorg Med Chem 26: 4234-4239 (2018)

More data for this
Ligand-Target Pair
Myc proto-oncogene protein


(Homo sapiens (Human))
BDBM50463130
PNG
(CHEMBL4247460)
Show SMILES NC(=O)c1ccc(cc1)-c1cc(nc(c1)-c1ccc(cc1)C#N)-c1cncs1
Show InChI InChI=1S/C22H14N4OS/c23-11-14-1-3-16(4-2-14)19-9-18(10-20(26-19)21-12-25-13-28-21)15-5-7-17(8-6-15)22(24)27/h1-10,12-13H,(H2,24,27)
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n/an/a 3.00E+4n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to ATG-Myc (unknown origin) expressed in CEF cells assessed as inhibition of microtumor formation


Bioorg Med Chem 26: 4234-4239 (2018)

More data for this
Ligand-Target Pair
Myc proto-oncogene protein


(Homo sapiens (Human))
BDBM50463131
PNG
(CHEMBL4248559)
Show SMILES NC(=O)c1ccc(cc1)-c1cc(nc(n1)-c1ccco1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C22H14N4O2/c23-13-14-3-5-15(6-4-14)18-12-19(16-7-9-17(10-8-16)21(24)27)26-22(25-18)20-2-1-11-28-20/h1-12H,(H2,24,27)
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n/an/a 7.00E+3n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to ATG-Myc (unknown origin) expressed in CEF cells assessed as inhibition of microtumor formation


Bioorg Med Chem 26: 4234-4239 (2018)

More data for this
Ligand-Target Pair
Myc proto-oncogene protein


(Homo sapiens (Human))
BDBM50463132
PNG
(CHEMBL4250683)
Show SMILES NC(=O)c1ccc(cc1)-c1cc(nc(c1)-c1cccc(F)c1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C25H16FN3O/c26-22-3-1-2-20(12-22)24-14-21(17-8-10-19(11-9-17)25(28)30)13-23(29-24)18-6-4-16(15-27)5-7-18/h1-14H,(H2,28,30)
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n/an/a>1.00E+5n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to ATG-Myc (unknown origin) expressed in CEF cells assessed as inhibition of microtumor formation


Bioorg Med Chem 26: 4234-4239 (2018)

More data for this
Ligand-Target Pair
Myc proto-oncogene protein


(Homo sapiens (Human))
BDBM50463133
PNG
(CHEMBL4240576)
Show SMILES NNC(=O)c1ccc(cc1)-c1cc(nc(c1)-c1ccc(cc1)C#N)-c1ccco1
Show InChI InChI=1S/C23H16N4O2/c24-14-15-3-5-17(6-4-15)20-12-19(13-21(26-20)22-2-1-11-29-22)16-7-9-18(10-8-16)23(28)27-25/h1-13H,25H2,(H,27,28)
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n/an/a>1.00E+5n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to ATG-Myc (unknown origin) expressed in CEF cells assessed as inhibition of microtumor formation


Bioorg Med Chem 26: 4234-4239 (2018)

More data for this
Ligand-Target Pair
Myc proto-oncogene protein


(Homo sapiens (Human))
BDBM50463134
PNG
(CHEMBL4246868)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(cc1)-c1cc(nc(c1)-c1ccc(cc1)C#N)-c1ccco1
Show InChI InChI=1S/C24H17N3O4S/c1-32(29,30)27-24(28)19-10-8-17(9-11-19)20-13-21(18-6-4-16(15-25)5-7-18)26-22(14-20)23-3-2-12-31-23/h2-14H,1H3,(H,27,28)
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n/an/a 1.00E+4n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to ATG-Myc (unknown origin) expressed in CEF cells assessed as inhibition of microtumor formation


Bioorg Med Chem 26: 4234-4239 (2018)

More data for this
Ligand-Target Pair
Myc proto-oncogene protein


(Homo sapiens (Human))
BDBM50463135
PNG
(CHEMBL4243878)
Show SMILES N#Cc1ccc(cc1)-c1cc(cc(n1)-c1ccco1)-c1ccc(cc1)-c1nnn[nH]1
Show InChI InChI=1S/C23H14N6O/c24-14-15-3-5-17(6-4-15)20-12-19(13-21(25-20)22-2-1-11-30-22)16-7-9-18(10-8-16)23-26-28-29-27-23/h1-13H,(H,26,27,28,29)
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n/an/a 2.00E+3n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to ATG-Myc (unknown origin) expressed in CEF cells assessed as inhibition of microtumor formation


Bioorg Med Chem 26: 4234-4239 (2018)

More data for this
Ligand-Target Pair
Myc proto-oncogene protein


(Homo sapiens (Human))
BDBM50463136
PNG
(CHEMBL4248116)
Show SMILES c1coc(c1)-c1cc(cc(n1)-c1ccc(cc1)-c1nccs1)-c1nccs1
Show InChI InChI=1S/C21H13N3OS2/c1-2-19(25-9-1)18-13-16(21-23-8-11-27-21)12-17(24-18)14-3-5-15(6-4-14)20-22-7-10-26-20/h1-13H
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n/an/a>1.00E+5n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to ATG-Myc (unknown origin) expressed in CEF cells assessed as inhibition of microtumor formation


Bioorg Med Chem 26: 4234-4239 (2018)

More data for this
Ligand-Target Pair
Myc proto-oncogene protein


(Homo sapiens (Human))
BDBM50463128
PNG
(CHEMBL4249055)
Show SMILES NC(=O)c1ccc(cc1)-c1cc(nc(c1)-c1ccc(cc1)-c1nccs1)-c1ccco1
Show InChI InChI=1S/C25H17N3O2S/c26-24(29)18-7-3-16(4-8-18)20-14-21(28-22(15-20)23-2-1-12-30-23)17-5-9-19(10-6-17)25-27-11-13-31-25/h1-15H,(H2,26,29)
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n/an/a 5.00E+3n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to ATG-Myc (unknown origin) expressed in CEF cells assessed as inhibition of microtumor formation


Bioorg Med Chem 26: 4234-4239 (2018)

More data for this
Ligand-Target Pair
Myc proto-oncogene protein


(Homo sapiens (Human))
BDBM50463137
PNG
(CHEMBL4241092)
Show SMILES NC(=O)c1ccc(cc1)-c1cc(nc(c1)-c1ccc(cc1)C#N)-c1cnco1
Show InChI InChI=1S/C22H14N4O2/c23-11-14-1-3-16(4-2-14)19-9-18(10-20(26-19)21-12-25-13-28-21)15-5-7-17(8-6-15)22(24)27/h1-10,12-13H,(H2,24,27)
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n/an/a>1.00E+5n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to ATG-Myc (unknown origin) expressed in CEF cells assessed as inhibition of microtumor formation


Bioorg Med Chem 26: 4234-4239 (2018)

More data for this
Ligand-Target Pair
Myc proto-oncogene protein


(Homo sapiens (Human))
BDBM50463138
PNG
(CHEMBL4240401)
Show SMILES NC(=O)c1ccc(cc1)-c1cc(nc(c1)-c1ccc(cc1)C#N)-c1ccco1
Show InChI InChI=1S/C23H15N3O2/c24-14-15-3-5-17(6-4-15)20-12-19(13-21(26-20)22-2-1-11-28-22)16-7-9-18(10-8-16)23(25)27/h1-13H,(H2,25,27)
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n/an/a 3.00E+3n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to ATG-Myc (unknown origin) expressed in CEF cells assessed as inhibition of microtumor formation


Bioorg Med Chem 26: 4234-4239 (2018)

More data for this
Ligand-Target Pair
Myc proto-oncogene protein


(Homo sapiens (Human))
BDBM50463139
PNG
(CHEMBL4243533)
Show SMILES NC(=O)c1ccc(cc1)-c1ccnc(c1)C#N
Show InChI InChI=1S/C13H9N3O/c14-8-12-7-11(5-6-16-12)9-1-3-10(4-2-9)13(15)17/h1-7H,(H2,15,17)
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n/an/a 1.00E+4n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to ATG-Myc (unknown origin) expressed in CEF cells assessed as inhibition of microtumor formation


Bioorg Med Chem 26: 4234-4239 (2018)

More data for this
Ligand-Target Pair
Myc proto-oncogene protein


(Homo sapiens (Human))
BDBM50463140
PNG
(CHEMBL4240109)
Show SMILES N#Cc1ccc(cc1)-c1cc(cc(n1)-c1ccco1)-c1ccccc1
Show InChI InChI=1S/C22H14N2O/c23-15-16-8-10-18(11-9-16)20-13-19(17-5-2-1-3-6-17)14-21(24-20)22-7-4-12-25-22/h1-14H
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n/an/a 5.00E+3n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to ATG-Myc (unknown origin) expressed in CEF cells assessed as inhibition of microtumor formation


Bioorg Med Chem 26: 4234-4239 (2018)

More data for this
Ligand-Target Pair
Myc proto-oncogene protein


(Homo sapiens (Human))
BDBM50463141
PNG
(CHEMBL4244986)
Show SMILES Cn1nncc1-c1cc(cc(n1)-c1ccc(cc1)C#N)-c1ccc(cc1)C(N)=O
Show InChI InChI=1S/C22H16N6O/c1-28-21(13-25-27-28)20-11-18(15-6-8-17(9-7-15)22(24)29)10-19(26-20)16-4-2-14(12-23)3-5-16/h2-11,13H,1H3,(H2,24,29)
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n/an/a 4.00E+4n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to ATG-Myc (unknown origin) expressed in CEF cells assessed as inhibition of microtumor formation


Bioorg Med Chem 26: 4234-4239 (2018)

More data for this
Ligand-Target Pair
Myc proto-oncogene protein


(Homo sapiens (Human))
BDBM50423921
PNG
(CHEMBL2312756)
Show SMILES [O-][N+](=O)c1ccc(Nc2ccccc2-c2ccccc2)c2nonc12
Show InChI InChI=1S/C18H12N4O3/c23-22(24)16-11-10-15(17-18(16)21-25-20-17)19-14-9-5-4-8-13(14)12-6-2-1-3-7-12/h1-11,19H
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CHEMBL
PC cid
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UniChem
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n/an/a 1.46E+5n/an/an/an/an/an/a



University of Maryland

Curated by ChEMBL


Assay Description
Inhibition of recombinant His6-tagged c-Myc bHLH-ZIP domain (353 to 437 amino acid residues) (unknown origin) assessed as disruption of Myc-Max dimer...


Bioorg Med Chem Lett 23: 370-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.013
BindingDB Entry DOI: 10.7270/Q2WM1FPM
More data for this
Ligand-Target Pair
Myc proto-oncogene protein


(Homo sapiens (Human))
BDBM93880
PNG
(4-(7-Nitro-benzo[1,2,5]oxadiazol-4-ylamino)-benzoi...)
Show SMILES OC(=O)c1ccc(Nc2ccc([N+]([O-])=O)c3nonc23)cc1
Show InChI InChI=1S/C13H8N4O5/c18-13(19)7-1-3-8(4-2-7)14-9-5-6-10(17(20)21)12-11(9)15-22-16-12/h1-6,14H,(H,18,19)
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n/an/a 3.30E+4n/an/an/an/an/an/a



University of Maryland

Curated by ChEMBL


Assay Description
Inhibition of recombinant His6-tagged c-Myc bHLH-ZIP domain (353 to 437 amino acid residues) (unknown origin) assessed as disruption of Myc-Max dimer...


Bioorg Med Chem Lett 23: 370-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.013
BindingDB Entry DOI: 10.7270/Q2WM1FPM
More data for this
Ligand-Target Pair
Myc proto-oncogene protein


(Homo sapiens (Human))
BDBM50431277
PNG
((Z)-3,4,3'',5''-Tetramethoxystilbene | (Z)-3,4,3',...)
Show SMILES COc1cc(OC)cc(\C=C/c2ccc(OC)c(OC)c2)c1
Show InChI InChI=1S/C18H20O4/c1-19-15-9-14(10-16(12-15)20-2)6-5-13-7-8-17(21-3)18(11-13)22-4/h5-12H,1-4H3/b6-5-
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n/an/a 6.00E+4n/an/an/an/an/an/a



The University of Mississippi

Curated by ChEMBL


Assay Description
Inhibition of Myc signaling pathway in human HeLa cells assessed as inhibition of PMA induced luciferase treated 30 mins before induction


J Nat Prod 76: 679-84 (2013)


Article DOI: 10.1021/np300893n
BindingDB Entry DOI: 10.7270/Q2ZW1N83
More data for this
Ligand-Target Pair
Myc proto-oncogene protein


(Homo sapiens (Human))
BDBM23926
PNG
((E)-resveratrol | 5-[(E)-2-(4-hydroxyphenyl)etheny...)
Show SMILES Oc1ccc(\C=C\c2cc(O)cc(O)c2)cc1
Show InChI InChI=1S/C14H12O3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9,15-17H/b2-1+
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n/an/a 6.00E+4n/an/an/an/an/an/a



The University of Mississippi

Curated by ChEMBL


Assay Description
Inhibition of Myc signaling pathway in human HeLa cells assessed as inhibition of PMA induced luciferase treated 30 mins before induction


J Nat Prod 76: 679-84 (2013)


Article DOI: 10.1021/np300893n
BindingDB Entry DOI: 10.7270/Q2ZW1N83
More data for this
Ligand-Target Pair