BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 1468 hits Enz. Inhib. hit(s) with Target = 'Neurokinin 2 receptor'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neurokinin 2 receptor


(Oryctolagus cuniculus)
BDBM50410048
PNG
(CHEMBL434548)
Show SMILES OC1CCN(CC1)C1CN(CC[C@@]2(CCC(=O)N(CC3CCC(F)(F)CC3)C2)c2ccc(Cl)c(Cl)c2)C1
Show InChI InChI=1S/C28H39Cl2F2N3O2/c29-24-2-1-21(15-25(24)30)27(11-14-33-17-22(18-33)34-12-6-23(36)7-13-34)8-5-26(37)35(19-27)16-20-3-9-28(31,32)10-4-20/h1-2,15,20,22-23,36H,3-14,16-19H2/t27-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 0.0794n/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
pA2 for NK2 receptor of rabbit pulmonary artery


Bioorg Med Chem Lett 15: 3957-61 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.134
BindingDB Entry DOI: 10.7270/Q20G3JQM
More data for this
Ligand-Target Pair
Neurokinin 2 receptor


(Oryctolagus cuniculus)
BDBM50410052
PNG
(CHEMBL367815)
Show SMILES FC1(F)CCC(CN2C[C@](CCN3CC(C3)N3CCC(=O)CC3)(CCC2=O)c2ccc(Cl)c(Cl)c2)CC1
Show InChI InChI=1S/C28H37Cl2F2N3O2/c29-24-2-1-21(15-25(24)30)27(11-14-33-17-22(18-33)34-12-6-23(36)7-13-34)8-5-26(37)35(19-27)16-20-3-9-28(31,32)10-4-20/h1-2,15,20,22H,3-14,16-19H2/t27-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 0.200n/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
pA2 for NK2 receptor of rabbit pulmonary artery


Bioorg Med Chem Lett 15: 3957-61 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.134
BindingDB Entry DOI: 10.7270/Q20G3JQM
More data for this
Ligand-Target Pair
Substance-K receptor


(Homo sapiens (Human))
BDBM50415924
PNG
(CHEMBL1083850)
Show SMILES Cc1ccc2cc(sc2c1)C(=O)NC1(CCCC1)C(=O)N[C@@H](CCCN1CCN(CC2CCOCC2)CC1)Cc1ccccc1
Show InChI InChI=1S/C37H50N4O3S/c1-28-11-12-31-26-34(45-33(31)24-28)35(42)39-37(15-5-6-16-37)36(43)38-32(25-29-8-3-2-4-9-29)10-7-17-40-18-20-41(21-19-40)27-30-13-22-44-23-14-30/h2-4,8-9,11-12,24,26,30,32H,5-7,10,13-23,25,27H2,1H3,(H,38,43)(H,39,42)/t32-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 0.200n/an/an/an/an/a



Menarini Ricerche

Curated by ChEMBL


Assay Description
Antagonist activity at NK2 receptor in human urinary bladder assessed as inhibition of [beta-Ala8]NKA(4-10)-induced tissue contractions


J Med Chem 53: 4148-65 (2010)


Article DOI: 10.1021/jm100176s
BindingDB Entry DOI: 10.7270/Q2MP54JT
More data for this
Ligand-Target Pair
Neurokinin 2 receptor


(Oryctolagus cuniculus)
BDBM50410049
PNG
(CHEMBL434142)
Show SMILES NC1CCN(CC1)C1CN(CC[C@@]2(CCC(=O)N(CC3CCC(F)(F)CC3)C2)c2ccc(Cl)c(Cl)c2)C1
Show InChI InChI=1S/C28H40Cl2F2N4O/c29-24-2-1-21(15-25(24)30)27(11-14-34-17-23(18-34)35-12-6-22(33)7-13-35)8-5-26(37)36(19-27)16-20-3-9-28(31,32)10-4-20/h1-2,15,20,22-23H,3-14,16-19,33H2/t27-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 0.200n/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
pA2 for NK2 receptor of rabbit pulmonary artery


Bioorg Med Chem Lett 15: 3957-61 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.134
BindingDB Entry DOI: 10.7270/Q20G3JQM
More data for this
Ligand-Target Pair
TACR2


(mouse)
BDBM50403645
PNG
(CHEMBL16180)
Show SMILES CC(C)C[C@@H]1NC(=O)[C@@H]2CNC(=O)C[C@H](NC(=O)[C@H](C)CNC1=O)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](Cc1ccccc1)C(=O)N2
Show InChI InChI=1S/C37H46N8O7/c1-20(2)13-26-33(48)40-17-21(3)32(47)41-29-16-31(46)39-19-30(37(52)42-26)45-34(49)27(14-22-9-5-4-6-10-22)43-35(50)28(44-36(29)51)15-23-18-38-25-12-8-7-11-24(23)25/h4-12,18,20-21,26-30,38H,13-17,19H2,1-3H3,(H,39,46)(H,40,48)(H,41,47)(H,42,52)(H,43,50)(H,44,51)(H,45,49)/t21-,26+,27+,28+,29+,30+/m1/s1
Reactome pathway

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 0.224n/an/an/an/an/a



Universit£ di Napoli Federico II

Curated by ChEMBL


Assay Description
pA2 value against Tachykinin receptor 2 in rat vas deferens


Bioorg Med Chem Lett 8: 1153-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00178-4
BindingDB Entry DOI: 10.7270/Q200038F
More data for this
Ligand-Target Pair
Neurokinin 2 receptor


(Oryctolagus cuniculus)
BDBM50170969
PNG
((S)-1-(1-Cyclopropyl-cyclopentyl)-5-(3,4-dichloro-...)
Show SMILES Clc1ccc(cc1Cl)[C@@]1(CCN2CC(C2)N2CCOCC2)CCC(=O)N(C1)C1(CCCC1)C1CC1
Show InChI InChI=1S/C28H39Cl2N3O2/c29-24-6-5-22(17-25(24)30)27(11-12-31-18-23(19-31)32-13-15-35-16-14-32)10-7-26(34)33(20-27)28(21-3-4-21)8-1-2-9-28/h5-6,17,21,23H,1-4,7-16,18-20H2/t27-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 0.251n/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
pA2 for NK2 receptor of rabbit pulmonary artery


Bioorg Med Chem Lett 15: 3957-61 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.134
BindingDB Entry DOI: 10.7270/Q20G3JQM
More data for this
Ligand-Target Pair
TACR2


(HAMSTER)
BDBM50407246
PNG
(CHEMBL334186)
Show SMILES CC(C)C[C@@H]1CN[C@@H](CCC(=O)NCc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1
Show InChI InChI=1S/C46H59N9O7/c1-29(2)23-33-28-50-36(18-20-41(57)51-26-31-13-7-4-8-14-31)44(60)53-37(17-19-40(47)56)45(61)55-39(25-32-27-49-35-16-10-9-15-34(32)35)46(62)54-38(24-30-11-5-3-6-12-30)43(59)48-22-21-42(58)52-33/h3-16,27,29,33,36-39,49-50H,17-26,28H2,1-2H3,(H2,47,56)(H,48,59)(H,51,57)(H,52,58)(H,53,60)(H,54,62)(H,55,61)/t33-,36+,37-,38-,39+/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 0.550n/an/an/an/an/a



A. Menarini Industrie Farmaceutiche Riunite

Curated by ChEMBL


Assay Description
Tested for antagonist activity at NK-2 tachykinin receptors in hamster trachea


J Med Chem 37: 3630-8 (1994)


Article DOI: 10.1021/jm00047a020
BindingDB Entry DOI: 10.7270/Q2X34ZNN
More data for this
Ligand-Target Pair
Substance-K receptor


(Homo sapiens (Human))
BDBM50170968
PNG
((S)-5-(3,4-Dichloro-phenyl)-1-(4,4-difluoro-cycloh...)
Show SMILES FC1CCN(CC1)C1CN(CC[C@@]2(CCC(=O)N(CC3CCC(F)(F)CC3)C2)c2ccc(Cl)c(Cl)c2)C1
Show InChI InChI=1S/C28H38Cl2F3N3O/c29-24-2-1-21(15-25(24)30)27(11-14-34-17-23(18-34)35-12-6-22(31)7-13-35)8-5-26(37)36(19-27)16-20-3-9-28(32,33)10-4-20/h1-2,15,20,22-23H,3-14,16-19H2/t27-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/a 0.631n/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
pA2 for NK2 receptor of human bladder IM9 cells


Bioorg Med Chem Lett 15: 3957-61 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.134
BindingDB Entry DOI: 10.7270/Q20G3JQM
More data for this
Ligand-Target Pair
TACR2


(HAMSTER)
BDBM50407241
PNG
(CHEMBL433191)
Show SMILES CC(C)C[C@@H]1CN[C@@H](CC2CCCCC2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1
Show InChI InChI=1S/C43H60N8O6/c1-27(2)21-31-26-47-35(22-28-11-5-3-6-12-28)42(56)49-34(17-18-38(44)52)41(55)51-37(24-30-25-46-33-16-10-9-15-32(30)33)43(57)50-36(23-29-13-7-4-8-14-29)40(54)45-20-19-39(53)48-31/h4,7-10,13-16,25,27-28,31,34-37,46-47H,3,5-6,11-12,17-24,26H2,1-2H3,(H2,44,52)(H,45,54)(H,48,53)(H,49,56)(H,50,57)(H,51,55)/t31-,34-,35+,36-,37+/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 0.871n/an/an/an/an/a



A. Menarini Industrie Farmaceutiche Riunite

Curated by ChEMBL


Assay Description
Tested for antagonist activity at NK-2 tachykinin receptors in hamster trachea


J Med Chem 37: 3630-8 (1994)


Article DOI: 10.1021/jm00047a020
BindingDB Entry DOI: 10.7270/Q2X34ZNN
More data for this
Ligand-Target Pair
Neurokinin 2 receptor


(Oryctolagus cuniculus)
BDBM50409627
PNG
(CHEMBL185572)
Show SMILES Clc1ccc(cc1Cl)[C@@]1(CCN2CC(C2)N2CCOCC2)CCC(=O)N(CC2CCCCC2)C1
Show InChI InChI=1S/C27H39Cl2N3O2/c28-24-7-6-22(16-25(24)29)27(10-11-30-18-23(19-30)31-12-14-34-15-13-31)9-8-26(33)32(20-27)17-21-4-2-1-3-5-21/h6-7,16,21,23H,1-5,8-15,17-20H2/t27-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 1n/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
pA2 for NK2 receptor of rabbit pulmonary artery


Bioorg Med Chem Lett 15: 3957-61 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.134
BindingDB Entry DOI: 10.7270/Q20G3JQM
More data for this
Ligand-Target Pair
Neurokinin 2 receptor


(Oryctolagus cuniculus)
BDBM50410051
PNG
(CHEMBL185182)
Show SMILES CS(=O)(=O)N1CCN(CC1)C1CN(CC[C@@]2(CCC(=O)N(CC3CCC(F)(F)CC3)C2)c2ccc(Cl)c(Cl)c2)C1
Show InChI InChI=1S/C28H40Cl2F2N4O3S/c1-40(38,39)36-14-12-34(13-15-36)23-18-33(19-23)11-10-27(22-2-3-24(29)25(30)16-22)7-6-26(37)35(20-27)17-21-4-8-28(31,32)9-5-21/h2-3,16,21,23H,4-15,17-20H2,1H3/t27-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 1n/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
pA2 for NK2 receptor of rabbit pulmonary artery


Bioorg Med Chem Lett 15: 3957-61 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.134
BindingDB Entry DOI: 10.7270/Q20G3JQM
More data for this
Ligand-Target Pair
Neurokinin 2 receptor


(Oryctolagus cuniculus)
BDBM50410056
PNG
(CHEMBL185007)
Show SMILES CN(C)S(=O)(=O)N1CCN(CC1)C1CN(CC[C@@]2(CCC(=O)N(CC3CC3)C2)c2ccc(Cl)c(Cl)c2)C1
Show InChI InChI=1S/C26H39Cl2N5O3S/c1-29(2)37(35,36)33-13-11-31(12-14-33)22-17-30(18-22)10-9-26(21-5-6-23(27)24(28)15-21)8-7-25(34)32(19-26)16-20-3-4-20/h5-6,15,20,22H,3-4,7-14,16-19H2,1-2H3/t26-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 1.26n/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
pA2 for NK2 receptor of rabbit pulmonary artery


Bioorg Med Chem Lett 15: 3957-61 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.134
BindingDB Entry DOI: 10.7270/Q20G3JQM
More data for this
Ligand-Target Pair
Neurokinin 2 receptor


(Oryctolagus cuniculus)
BDBM50410057
PNG
(CHEMBL359655)
Show SMILES FC1(F)CCC(CN2C[C@](CCN3CC(C3)N3CCOCC3)(CCC2=O)c2ccc(Cl)c(Cl)c2)CC1
Show InChI InChI=1S/C27H37Cl2F2N3O2/c28-23-2-1-21(15-24(23)29)26(9-10-32-17-22(18-32)33-11-13-36-14-12-33)6-5-25(35)34(19-26)16-20-3-7-27(30,31)8-4-20/h1-2,15,20,22H,3-14,16-19H2/t26-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 1.26n/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
pA2 for NK2 receptor of rabbit pulmonary artery


Bioorg Med Chem Lett 15: 3957-61 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.134
BindingDB Entry DOI: 10.7270/Q20G3JQM
More data for this
Ligand-Target Pair
Neurokinin 2 receptor


(Oryctolagus cuniculus)
BDBM50410047
PNG
(CHEMBL365613 | UK-224671)
Show SMILES NS(=O)(=O)N1CCN(CC1)C1CN(CC[C@@]2(CCC(=O)N(CC3CC3)C2)c2ccc(Cl)c(Cl)c2)C1
Show InChI InChI=1S/C24H35Cl2N5O3S/c25-21-4-3-19(13-22(21)26)24(6-5-23(32)30(17-24)14-18-1-2-18)7-8-28-15-20(16-28)29-9-11-31(12-10-29)35(27,33)34/h3-4,13,18,20H,1-2,5-12,14-17H2,(H2,27,33,34)/t24-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 1.26n/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
pA2 for NK2 receptor of rabbit pulmonary artery


Bioorg Med Chem Lett 15: 3957-61 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.134
BindingDB Entry DOI: 10.7270/Q20G3JQM
More data for this
Ligand-Target Pair
Substance-K receptor


(Homo sapiens (Human))
BDBM50410047
PNG
(CHEMBL365613 | UK-224671)
Show SMILES NS(=O)(=O)N1CCN(CC1)C1CN(CC[C@@]2(CCC(=O)N(CC3CC3)C2)c2ccc(Cl)c(Cl)c2)C1
Show InChI InChI=1S/C24H35Cl2N5O3S/c25-21-4-3-19(13-22(21)26)24(6-5-23(32)30(17-24)14-18-1-2-18)7-8-28-15-20(16-28)29-9-11-31(12-10-29)35(27,33)34/h3-4,13,18,20H,1-2,5-12,14-17H2,(H2,27,33,34)/t24-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 1.58n/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
pA2 for NK2 receptor of Human bladder


Bioorg Med Chem Lett 15: 3957-61 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.134
BindingDB Entry DOI: 10.7270/Q20G3JQM
More data for this
Ligand-Target Pair
Neurokinin 2 receptor


(Oryctolagus cuniculus)
BDBM50410054
PNG
(CHEMBL185133)
Show SMILES FC1CCN(CC1)C1CN(CC[C@@]2(CCC(=O)N(CCC3CC3)C2)c2ccc(Cl)c(Cl)c2)C1
Show InChI InChI=1S/C26H36Cl2FN3O/c27-23-4-3-20(15-24(23)28)26(9-5-25(33)32(18-26)11-6-19-1-2-19)10-14-30-16-22(17-30)31-12-7-21(29)8-13-31/h3-4,15,19,21-22H,1-2,5-14,16-18H2/t26-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 1.58n/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
pA2 for NK2 receptor of rabbit pulmonary artery


Bioorg Med Chem Lett 15: 3957-61 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.134
BindingDB Entry DOI: 10.7270/Q20G3JQM
More data for this
Ligand-Target Pair
TACR2


(HAMSTER)
BDBM50407244
PNG
(CHEMBL121271)
Show SMILES CC(C)C[C@@H]1CN[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1
Show InChI InChI=1S/C47H56N8O6/c1-29(2)22-35-28-51-39(25-31-16-17-32-12-6-7-13-33(32)23-31)46(60)53-38(18-19-42(48)56)45(59)55-41(26-34-27-50-37-15-9-8-14-36(34)37)47(61)54-40(24-30-10-4-3-5-11-30)44(58)49-21-20-43(57)52-35/h3-17,23,27,29,35,38-41,50-51H,18-22,24-26,28H2,1-2H3,(H2,48,56)(H,49,58)(H,52,57)(H,53,60)(H,54,61)(H,55,59)/t35-,38-,39+,40-,41+/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 1.60n/an/an/an/an/a



A. Menarini Industrie Farmaceutiche Riunite

Curated by ChEMBL


Assay Description
Tested for antagonist activity at NK-2 tachykinin receptors in hamster trachea


J Med Chem 37: 3630-8 (1994)


Article DOI: 10.1021/jm00047a020
BindingDB Entry DOI: 10.7270/Q2X34ZNN
More data for this
Ligand-Target Pair
Neurokinin 2 receptor


(Oryctolagus cuniculus)
BDBM50410053
PNG
(CHEMBL360721)
Show SMILES Clc1ccc(cc1Cl)[C@@]1(CCN2CC(C2)N2CCOCC2)CCC(=O)N(CC2CC2)C1
Show InChI InChI=1S/C24H33Cl2N3O2/c25-21-4-3-19(13-22(21)26)24(6-5-23(30)29(17-24)14-18-1-2-18)7-8-27-15-20(16-27)28-9-11-31-12-10-28/h3-4,13,18,20H,1-2,5-12,14-17H2/t24-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 2n/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
pA2 for NK2 receptor of rabbit pulmonary artery


Bioorg Med Chem Lett 15: 3957-61 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.134
BindingDB Entry DOI: 10.7270/Q20G3JQM
More data for this
Ligand-Target Pair
Neurokinin 2 receptor


(Oryctolagus cuniculus)
BDBM50410046
PNG
(CHEMBL367348)
Show SMILES NC1CCN(CC1)C1CN(CC[C@@]2(CCC(=O)N(CC3CC3)C2)c2ccc(Cl)c(Cl)c2)C1
Show InChI InChI=1S/C25H36Cl2N4O/c26-22-4-3-19(13-23(22)27)25(8-5-24(32)31(17-25)14-18-1-2-18)9-12-29-15-21(16-29)30-10-6-20(28)7-11-30/h3-4,13,18,20-21H,1-2,5-12,14-17,28H2/t25-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 2n/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
pA2 for NK2 receptor of rabbit pulmonary artery


Bioorg Med Chem Lett 15: 3957-61 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.134
BindingDB Entry DOI: 10.7270/Q20G3JQM
More data for this
Ligand-Target Pair
TACR2


(HAMSTER)
BDBM50407235
PNG
(CHEMBL331480)
Show SMILES CC(C)C[C@@H]1CN[C@@H](CCC(N)OCc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1
Show InChI InChI=1S/C46H61N9O7/c1-29(2)23-33-27-51-36(18-20-41(48)62-28-31-13-7-4-8-14-31)44(59)53-37(17-19-40(47)56)45(60)55-39(25-32-26-50-35-16-10-9-15-34(32)35)46(61)54-38(24-30-11-5-3-6-12-30)43(58)49-22-21-42(57)52-33/h3-16,26,29,33,36-39,41,50-51H,17-25,27-28,48H2,1-2H3,(H2,47,56)(H,49,58)(H,52,57)(H,53,59)(H,54,61)(H,55,60)/t33-,36+,37-,38-,39+,41?/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/a 2.20n/an/an/an/an/a



A. Menarini Industrie Farmaceutiche Riunite

Curated by ChEMBL


Assay Description
Tested for antagonist activity at NK-2 tachykinin receptors in hamster trachea


J Med Chem 37: 3630-8 (1994)


Article DOI: 10.1021/jm00047a020
BindingDB Entry DOI: 10.7270/Q2X34ZNN
More data for this
Ligand-Target Pair
Neurokinin 2 receptor


(Oryctolagus cuniculus)
BDBM50410050
PNG
(CHEMBL359903)
Show SMILES FC1CCN(CC1)C1CN(CC[C@@]2(CCC(=O)N(CC3CC3)C2)c2ccc(Cl)c(Cl)c2)C1
Show InChI InChI=1S/C25H34Cl2FN3O/c26-22-4-3-19(13-23(22)27)25(8-5-24(32)31(17-25)14-18-1-2-18)9-12-29-15-21(16-29)30-10-6-20(28)7-11-30/h3-4,13,18,20-21H,1-2,5-12,14-17H2/t25-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 2.51n/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
pA2 for NK2 receptor of rabbit pulmonary artery


Bioorg Med Chem Lett 15: 3957-61 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.134
BindingDB Entry DOI: 10.7270/Q20G3JQM
More data for this
Ligand-Target Pair
Neurokinin 2 receptor


(Oryctolagus cuniculus)
BDBM50410058
PNG
(CHEMBL185452)
Show SMILES CS(=O)(=O)N1CCN(CC1)C1CN(CC[C@@]2(CCC(=O)N(CC3CC3)C2)c2ccc(Cl)c(Cl)c2)C1
Show InChI InChI=1S/C25H36Cl2N4O3S/c1-35(33,34)31-12-10-29(11-13-31)21-16-28(17-21)9-8-25(20-4-5-22(26)23(27)14-20)7-6-24(32)30(18-25)15-19-2-3-19/h4-5,14,19,21H,2-3,6-13,15-18H2,1H3/t25-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 3.16n/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
pA2 for NK2 receptor of rabbit pulmonary artery


Bioorg Med Chem Lett 15: 3957-61 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.134
BindingDB Entry DOI: 10.7270/Q20G3JQM
More data for this
Ligand-Target Pair
TACR2


(HAMSTER)
BDBM50407238
PNG
(CHEMBL333515)
Show SMILES CC(C)C[C@@H]1CN(C)[C@@H](CC2CCCCC2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1
Show InChI InChI=1S/C44H62N8O6/c1-28(2)22-32-27-52(3)38(24-30-14-8-5-9-15-30)44(58)49-35(18-19-39(45)53)42(56)51-37(25-31-26-47-34-17-11-10-16-33(31)34)43(57)50-36(23-29-12-6-4-7-13-29)41(55)46-21-20-40(54)48-32/h4,6-7,10-13,16-17,26,28,30,32,35-38,47H,5,8-9,14-15,18-25,27H2,1-3H3,(H2,45,53)(H,46,55)(H,48,54)(H,49,58)(H,50,57)(H,51,56)/t32-,35-,36-,37+,38+/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 3.80n/an/an/an/an/a



A. Menarini Industrie Farmaceutiche Riunite

Curated by ChEMBL


Assay Description
Tested for antagonist activity at NK-2 tachykinin receptors in hamster trachea


J Med Chem 37: 3630-8 (1994)


Article DOI: 10.1021/jm00047a020
BindingDB Entry DOI: 10.7270/Q2X34ZNN
More data for this
Ligand-Target Pair
TACR2


(mouse)
BDBM50408387
PNG
(CHEMBL156128)
Show SMILES CC(O)C(NC(C)=O)C(=O)N[C@H](Cc1cc2ccccc2n1C(C)=O)C(=O)N1C2CCCCC2CC1C(=O)N(C)Cc1ccccc1
Show InChI InChI=1S/C36H45N5O6/c1-22(42)33(37-23(2)43)34(45)38-29(20-28-18-26-14-8-10-16-30(26)40(28)24(3)44)35(46)41-31-17-11-9-15-27(31)19-32(41)36(47)39(4)21-25-12-6-5-7-13-25/h5-8,10,12-14,16,18,22,27,29,31-33,42H,9,11,15,17,19-21H2,1-4H3,(H,37,43)(H,38,45)/t22?,27?,29-,31?,32?,33?/m1/s1
Reactome pathway

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 3.98n/an/an/an/an/a



Universit£ degli Studi di Napoli Federico II

Curated by ChEMBL


Assay Description
Antagonistic activity against Tachykinin receptor 2 was determined in the rat colon muscolaris mucosae (RC)


J Med Chem 40: 594-601 (1997)


Article DOI: 10.1021/jm960213s
BindingDB Entry DOI: 10.7270/Q27945VP
More data for this
Ligand-Target Pair
Substance-K receptor


(Homo sapiens (Human))
BDBM50404000
PNG
(CHEMBL100298)
Show SMILES O=C(N(CCCN1CCSCC1)CCc1c[nH]c2ccccc12)c1ccccc1C(=O)N(CCCN1CCSCC1)CCc1c[nH]c2ccccc12
Show InChI InChI=1S/C42H52N6O2S2/c49-41(47(19-7-17-45-23-27-51-28-24-45)21-15-33-31-43-39-13-5-3-9-35(33)39)37-11-1-2-12-38(37)42(50)48(20-8-18-46-25-29-52-30-26-46)22-16-34-32-44-40-14-6-4-10-36(34)40/h1-6,9-14,31-32,43-44H,7-8,15-30H2
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 3.98n/an/an/an/an/a



Menarini Ricerche S.p.A.

Curated by ChEMBL


Assay Description
Functional affinity was evaluated by measuring the intracellular calcium concentration in CHO cells transfected with the human Tachykinin receptor 2 ...


Bioorg Med Chem Lett 12: 2945-8 (2002)


Article DOI: 10.1016/s0960-894x(02)00539-5
BindingDB Entry DOI: 10.7270/Q2KK9CZ8
More data for this
Ligand-Target Pair
TACR2


(HAMSTER)
BDBM50407240
PNG
(CHEMBL427606)
Show SMILES CC(C)C[C@@H]1CN[C@@H](CC(=O)N(N)C[C@]23C[C@H]4C[C@H](C[C@H](C4)C2)C3)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1
Show InChI InChI=1S/C49H68N10O7/c1-29(2)16-35-27-54-39(22-44(62)59(51)28-49-23-31-17-32(24-49)19-33(18-31)25-49)47(65)56-38(12-13-42(50)60)46(64)58-41(21-34-26-53-37-11-7-6-10-36(34)37)48(66)57-40(20-30-8-4-3-5-9-30)45(63)52-15-14-43(61)55-35/h3-11,26,29,31-33,35,38-41,53-54H,12-25,27-28,51H2,1-2H3,(H2,50,60)(H,52,63)(H,55,61)(H,56,65)(H,57,66)(H,58,64)/t31-,32+,33-,35-,38-,39+,40-,41+,49-/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 4.10n/an/an/an/an/a



A. Menarini Industrie Farmaceutiche Riunite

Curated by ChEMBL


Assay Description
Tested for antagonist activity at NK-2 tachykinin receptors in hamster trachea


J Med Chem 37: 3630-8 (1994)


Article DOI: 10.1021/jm00047a020
BindingDB Entry DOI: 10.7270/Q2X34ZNN
More data for this
Ligand-Target Pair
TACR2


(mouse)
BDBM50403646
PNG
(CHEMBL278223)
Show SMILES CC(C)C[C@@H]1NC(=O)[C@@H]2CNC(=O)C[C@H](NC(=O)[C@H](CSCC3O[C@@H](O)C(O)[C@H](O)[C@H]3O)CNC1=O)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](Cc1ccccc1)C(=O)N2
Show InChI InChI=1S/C43H56N8O12S/c1-21(2)12-27-38(57)46-17-24(19-64-20-32-34(53)35(54)36(55)43(62)63-32)37(56)47-30-15-33(52)45-18-31(42(61)48-27)51-39(58)28(13-22-8-4-3-5-9-22)49-40(59)29(50-41(30)60)14-23-16-44-26-11-7-6-10-25(23)26/h3-11,16,21,24,27-32,34-36,43-44,53-55,62H,12-15,17-20H2,1-2H3,(H,45,52)(H,46,57)(H,47,56)(H,48,61)(H,49,59)(H,50,60)(H,51,58)/t24-,27-,28-,29-,30-,31-,32?,34-,35+,36?,43+/m0/s1
Reactome pathway

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/a 5.62n/an/an/an/an/a



Universit£ di Napoli Federico II

Curated by ChEMBL


Assay Description
pA2 value against Tachykinin receptor 2 in rat vas deferens


Bioorg Med Chem Lett 8: 1153-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00178-4
BindingDB Entry DOI: 10.7270/Q200038F
More data for this
Ligand-Target Pair
TACR2


(mouse)
BDBM50366377
PNG
(CHEMBL334721 | MEN-10627)
Show SMILES CSCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CNC(=O)C[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](Cc1ccccc1)C(=O)N2
Show InChI InChI=1S/C38H48N8O7S/c1-21(2)15-27-34(49)41-26(13-14-54-3)33(48)45-30-18-32(47)40-20-31(38(53)42-27)46-35(50)28(16-22-9-5-4-6-10-22)43-36(51)29(44-37(30)52)17-23-19-39-25-12-8-7-11-24(23)25/h4-12,19,21,26-31,39H,13-18,20H2,1-3H3,(H,40,47)(H,41,49)(H,42,53)(H,43,51)(H,44,52)(H,45,48)(H,46,50)/t26-,27-,28-,29-,30-,31-/m0/s1
Reactome pathway

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 6.17n/an/an/an/an/a



Universit£ di Napoli Federico II

Curated by ChEMBL


Assay Description
Compound was evaluated for antagonistic activity towards Tachykinin receptor 2 in rat vas deferens


Bioorg Med Chem Lett 8: 1735-40 (1999)


Article DOI: 10.1016/s0960-894x(98)00282-0
BindingDB Entry DOI: 10.7270/Q2QF8V2W
More data for this
Ligand-Target Pair
TACR2


(mouse)
BDBM50366377
PNG
(CHEMBL334721 | MEN-10627)
Show SMILES CSCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CNC(=O)C[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](Cc1ccccc1)C(=O)N2
Show InChI InChI=1S/C38H48N8O7S/c1-21(2)15-27-34(49)41-26(13-14-54-3)33(48)45-30-18-32(47)40-20-31(38(53)42-27)46-35(50)28(16-22-9-5-4-6-10-22)43-36(51)29(44-37(30)52)17-23-19-39-25-12-8-7-11-24(23)25/h4-12,19,21,26-31,39H,13-18,20H2,1-3H3,(H,40,47)(H,41,49)(H,42,53)(H,43,51)(H,44,52)(H,45,48)(H,46,50)/t26-,27-,28-,29-,30-,31-/m0/s1
Reactome pathway

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 6.17n/an/an/an/an/a



Universit£ di Napoli Federico II

Curated by ChEMBL


Assay Description
pA2 value against Tachykinin receptor 2 in rat vas deferens


Bioorg Med Chem Lett 8: 1153-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00178-4
BindingDB Entry DOI: 10.7270/Q200038F
More data for this
Ligand-Target Pair
Neurokinin 2 receptor


(Oryctolagus cuniculus)
BDBM50410055
PNG
(CHEMBL180049)
Show SMILES CCOC1CCN(CC1)C1CN(CC[C@@]2(CCC(=O)N(CC3CC3)C2)c2ccc(Cl)c(Cl)c2)C1
Show InChI InChI=1S/C27H39Cl2N3O2/c1-2-34-23-8-12-31(13-9-23)22-17-30(18-22)14-11-27(21-5-6-24(28)25(29)15-21)10-7-26(33)32(19-27)16-20-3-4-20/h5-6,15,20,22-23H,2-4,7-14,16-19H2,1H3/t27-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 6.31n/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
pA2 for NK2 receptor of rabbit pulmonary artery


Bioorg Med Chem Lett 15: 3957-61 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.134
BindingDB Entry DOI: 10.7270/Q20G3JQM
More data for this
Ligand-Target Pair
TACR2


(HAMSTER)
BDBM50407249
PNG
(CHEMBL333027)
Show SMILES CC(C)C[C@@H]1CN[C@@H](CCCCNC(=O)OCc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1
Show InChI InChI=1S/C48H63N9O8/c1-31(2)25-35-29-53-38(19-11-12-23-51-48(64)65-30-33-15-7-4-8-16-33)45(61)55-39(20-21-42(49)58)46(62)57-41(27-34-28-52-37-18-10-9-17-36(34)37)47(63)56-40(26-32-13-5-3-6-14-32)44(60)50-24-22-43(59)54-35/h3-10,13-18,28,31,35,38-41,52-53H,11-12,19-27,29-30H2,1-2H3,(H2,49,58)(H,50,60)(H,51,64)(H,54,59)(H,55,61)(H,56,63)(H,57,62)/t35-,38+,39-,40-,41+/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 6.80n/an/an/an/an/a



A. Menarini Industrie Farmaceutiche Riunite

Curated by ChEMBL


Assay Description
Tested for antagonist activity at NK-2 tachykinin receptors in hamster trachea


J Med Chem 37: 3630-8 (1994)


Article DOI: 10.1021/jm00047a020
BindingDB Entry DOI: 10.7270/Q2X34ZNN
More data for this
Ligand-Target Pair
TACR2


(mouse)
BDBM50406733
PNG
(CHEMBL2370702)
Show SMILES CSCC[C@H]1NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCC(N)=O)NC1=O
Show InChI InChI=1S/C38H50N8O7S/c1-22(2)17-29-37(52)44-28(15-16-54-3)36(51)43-27(13-14-32(39)47)35(50)46-31(19-24-20-40-26-12-8-7-11-25(24)26)38(53)45-30(18-23-9-5-4-6-10-23)34(49)41-21-33(48)42-29/h4-12,20,22,27-31,40H,13-19,21H2,1-3H3,(H2,39,47)(H,41,49)(H,42,48)(H,43,51)(H,44,52)(H,45,53)(H,46,50)/t27-,28+,29-,30-,31+/m0/s1
Reactome pathway

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 7.94n/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferens


J Med Chem 36: 2-10 (1993)


Article DOI: 10.1021/jm00053a001
BindingDB Entry DOI: 10.7270/Q26M3821
More data for this
Ligand-Target Pair
Substance-K receptor


(Homo sapiens (Human))
BDBM50403999
PNG
(CHEMBL100297)
Show SMILES CN(CCc1c[nH]c2ccccc12)C(=O)c1ccccc1C(=O)N(CCCN1CCSCC1)CCc1c[nH]c2ccccc12
Show InChI InChI=1S/C36H41N5O2S/c1-39(19-15-27-25-37-33-13-6-4-9-29(27)33)35(42)31-11-2-3-12-32(31)36(43)41(18-8-17-40-21-23-44-24-22-40)20-16-28-26-38-34-14-7-5-10-30(28)34/h2-7,9-14,25-26,37-38H,8,15-24H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 10n/an/an/an/an/a



Menarini Ricerche S.p.A.

Curated by ChEMBL


Assay Description
Functional affinity was evaluated by measuring the intracellular calcium concentration in CHO cells transfected with the human Tachykinin receptor 2 ...


Bioorg Med Chem Lett 12: 2945-8 (2002)


Article DOI: 10.1016/s0960-894x(02)00539-5
BindingDB Entry DOI: 10.7270/Q2KK9CZ8
More data for this
Ligand-Target Pair
Substance-K receptor


(Homo sapiens (Human))
BDBM50099628
PNG
(3-[1,4']Bipiperidinyl-1'-ylmethyl-2-phenyl-quinoli...)
Show SMILES C[C@H](NC(=O)c1c(CN2CCC(CC2)N2CCCCC2)c(nc2ccccc12)-c1ccccc1)C1CCCCC1
Show InChI InChI=1S/C35H46N4O/c1-26(27-13-5-2-6-14-27)36-35(40)33-30-17-9-10-18-32(30)37-34(28-15-7-3-8-16-28)31(33)25-38-23-19-29(20-24-38)39-21-11-4-12-22-39/h3,7-10,15-18,26-27,29H,2,4-6,11-14,19-25H2,1H3,(H,36,40)/t26-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 10n/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Cellular functional antagonistic activity against NKB-induced [Ca2+] mobilization in HEK cells stably expressing the tachykinin receptor 2


J Med Chem 44: 1675-89 (2001)


Article DOI: 10.1021/jm000501v
BindingDB Entry DOI: 10.7270/Q29C6WQN
More data for this
Ligand-Target Pair
TACR2


(HAMSTER)
BDBM50407242
PNG
(CHEMBL121571)
Show SMILES CSCC[C@@H]1NC[C@@H](CC(C)C)NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(N)=O)NC1=O
Show InChI InChI=1S/C39H54N8O6S/c1-24(2)19-27-23-43-30(16-18-54-3)37(51)45-31(13-14-34(40)48)38(52)47-33(21-26-22-42-29-12-8-7-11-28(26)29)39(53)46-32(20-25-9-5-4-6-10-25)36(50)41-17-15-35(49)44-27/h4-12,22,24,27,30-33,42-43H,13-21,23H2,1-3H3,(H2,40,48)(H,41,50)(H,44,49)(H,45,51)(H,46,53)(H,47,52)/t27-,30+,31-,32-,33+/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 13n/an/an/an/an/a



A. Menarini Industrie Farmaceutiche Riunite

Curated by ChEMBL


Assay Description
Tested for antagonist activity at NK-2 tachykinin receptors in hamster trachea


J Med Chem 37: 3630-8 (1994)


Article DOI: 10.1021/jm00047a020
BindingDB Entry DOI: 10.7270/Q2X34ZNN
More data for this
Ligand-Target Pair
Neurokinin 2 receptor


(Oryctolagus cuniculus)
BDBM50407246
PNG
(CHEMBL334186)
Show SMILES CC(C)C[C@@H]1CN[C@@H](CCC(=O)NCc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1
Show InChI InChI=1S/C46H59N9O7/c1-29(2)23-33-28-50-36(18-20-41(57)51-26-31-13-7-4-8-14-31)44(60)53-37(17-19-40(47)56)45(61)55-39(25-32-27-49-35-16-10-9-15-34(32)35)46(62)54-38(24-30-11-5-3-6-12-30)43(59)48-22-21-42(58)52-33/h3-16,27,29,33,36-39,49-50H,17-26,28H2,1-2H3,(H2,47,56)(H,48,59)(H,51,57)(H,52,58)(H,53,60)(H,54,62)(H,55,61)/t33-,36+,37-,38-,39+/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 15n/an/an/an/an/a



A. Menarini Industrie Farmaceutiche Riunite

Curated by ChEMBL


Assay Description
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery


J Med Chem 37: 3630-8 (1994)


Article DOI: 10.1021/jm00047a020
BindingDB Entry DOI: 10.7270/Q2X34ZNN
More data for this
Ligand-Target Pair
TACR2


(HAMSTER)
BDBM50407248
PNG
(CHEMBL421062)
Show SMILES CC(C)C[C@@H]1CN[C@@H](CC(C)C)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1
Show InChI InChI=1S/C40H56N8O6/c1-24(2)18-28-23-44-32(19-25(3)4)39(53)46-31(14-15-35(41)49)38(52)48-34(21-27-22-43-30-13-9-8-12-29(27)30)40(54)47-33(20-26-10-6-5-7-11-26)37(51)42-17-16-36(50)45-28/h5-13,22,24-25,28,31-34,43-44H,14-21,23H2,1-4H3,(H2,41,49)(H,42,51)(H,45,50)(H,46,53)(H,47,54)(H,48,52)/t28-,31-,32+,33-,34+/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 16n/an/an/an/an/a



A. Menarini Industrie Farmaceutiche Riunite

Curated by ChEMBL


Assay Description
Tested for antagonist activity at NK-2 tachykinin receptors in hamster trachea


J Med Chem 37: 3630-8 (1994)


Article DOI: 10.1021/jm00047a020
BindingDB Entry DOI: 10.7270/Q2X34ZNN
More data for this
Ligand-Target Pair
TACR2


(HAMSTER)
BDBM50407236
PNG
(CHEMBL330810)
Show SMILES CC(C)C[C@@H]1CN[C@@H](Cc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1
Show InChI InChI=1S/C43H54N8O6/c1-27(2)21-31-26-47-35(22-28-11-5-3-6-12-28)42(56)49-34(17-18-38(44)52)41(55)51-37(24-30-25-46-33-16-10-9-15-32(30)33)43(57)50-36(23-29-13-7-4-8-14-29)40(54)45-20-19-39(53)48-31/h3-16,25,27,31,34-37,46-47H,17-24,26H2,1-2H3,(H2,44,52)(H,45,54)(H,48,53)(H,49,56)(H,50,57)(H,51,55)/t31-,34-,35+,36-,37+/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 19n/an/an/an/an/a



A. Menarini Industrie Farmaceutiche Riunite

Curated by ChEMBL


Assay Description
Tested for antagonist activity at NK-2 tachykinin receptors in hamster trachea


J Med Chem 37: 3630-8 (1994)


Article DOI: 10.1021/jm00047a020
BindingDB Entry DOI: 10.7270/Q2X34ZNN
More data for this
Ligand-Target Pair
Neurokinin 2 receptor


(Oryctolagus cuniculus)
BDBM50407410
PNG
(CHEMBL429340)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(O)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O
Show InChI InChI=1S/C57H67N13O11/c1-30(2)49(70-54(78)47(25-34-29-64-42-15-8-5-12-38(34)42)68-51(75)44(22-31-17-19-35(71)20-18-31)66-50(74)39(58)26-48(72)73)55(79)69-46(24-33-28-63-41-14-7-4-11-37(33)41)53(77)67-45(23-32-27-62-40-13-6-3-10-36(32)40)52(76)65-43(56(80)81)16-9-21-61-57(59)60/h3-8,10-15,17-20,27-30,39,43-47,49,62-64,71H,9,16,21-26,58H2,1-2H3,(H,65,76)(H,66,74)(H,67,77)(H,68,75)(H,69,79)(H,70,78)(H,72,73)(H,80,81)(H4,59,60,61)/t39-,43-,44-,45+,46+,47+,49-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 22n/an/an/an/an/a



University of Illinois at Chicago

Curated by ChEMBL


Assay Description
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.


J Med Chem 38: 2705-13 (1995)


Article DOI: 10.1021/jm00014a022
BindingDB Entry DOI: 10.7270/Q2GX4CSN
More data for this
Ligand-Target Pair
Neurokinin 2 receptor


(GUINEA PIG)
BDBM50366377
PNG
(CHEMBL334721 | MEN-10627)
Show SMILES CSCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CNC(=O)C[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](Cc1ccccc1)C(=O)N2
Show InChI InChI=1S/C38H48N8O7S/c1-21(2)15-27-34(49)41-26(13-14-54-3)33(48)45-30-18-32(47)40-20-31(38(53)42-27)46-35(50)28(16-22-9-5-4-6-10-22)43-36(51)29(44-37(30)52)17-23-19-39-25-12-8-7-11-24(23)25/h4-12,19,21,26-31,39H,13-18,20H2,1-3H3,(H,40,47)(H,41,49)(H,42,53)(H,43,51)(H,44,52)(H,45,48)(H,46,50)/t26-,27-,28-,29-,30-,31-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 23n/an/an/an/an/a



Universit£ di Napoli Federico II

Curated by ChEMBL


Assay Description
Compound was evaluated for antagonistic activity towards Tachykinin receptor 2 at guinea pig trachea


Bioorg Med Chem Lett 8: 1735-40 (1999)


Article DOI: 10.1016/s0960-894x(98)00282-0
BindingDB Entry DOI: 10.7270/Q2QF8V2W
More data for this
Ligand-Target Pair
TACR2


(mouse)
BDBM50407416
PNG
(CHEMBL412830)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(O)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(O)=O)C(O)=O
Show InChI InChI=1S/C56H62N10O13/c1-29(2)49(66-54(76)46(24-33-28-60-41-14-8-5-11-37(33)41)64-51(73)43(21-30-15-17-34(67)18-16-30)62-50(72)38(57)25-48(70)71)55(77)65-45(23-32-27-59-40-13-7-4-10-36(32)40)53(75)63-44(22-31-26-58-39-12-6-3-9-35(31)39)52(74)61-42(56(78)79)19-20-47(68)69/h3-18,26-29,38,42-46,49,58-60,67H,19-25,57H2,1-2H3,(H,61,74)(H,62,72)(H,63,75)(H,64,73)(H,65,77)(H,66,76)(H,68,69)(H,70,71)(H,78,79)/t38-,42-,43-,44+,45+,46+,49-/m0/s1
Reactome pathway

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 30.9n/an/an/an/an/a



University of Illinois at Chicago

Curated by ChEMBL


Assay Description
Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)


J Med Chem 38: 2705-13 (1995)


Article DOI: 10.1021/jm00014a022
BindingDB Entry DOI: 10.7270/Q2GX4CSN
More data for this
Ligand-Target Pair
TACR2


(HAMSTER)
BDBM50407245
PNG
(CHEMBL421071)
Show SMILES CC(C)C[C@H]1NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](CC2CCCCC2)NC1=O
Show InChI InChI=1S/C43H58N8O7/c1-26(2)21-33-41(56)50-35(23-28-13-7-4-8-14-28)42(57)48-32(17-18-37(44)52)40(55)51-36(24-29-25-46-31-16-10-9-15-30(29)31)43(58)49-34(22-27-11-5-3-6-12-27)39(54)45-20-19-38(53)47-33/h3,5-6,9-12,15-16,25-26,28,32-36,46H,4,7-8,13-14,17-24H2,1-2H3,(H2,44,52)(H,45,54)(H,47,53)(H,48,57)(H,49,58)(H,50,56)(H,51,55)/t32-,33-,34-,35+,36+/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 32n/an/an/an/an/a



A. Menarini Industrie Farmaceutiche Riunite

Curated by ChEMBL


Assay Description
Tested for antagonist activity at NK-2 tachykinin receptors in hamster trachea


J Med Chem 37: 3630-8 (1994)


Article DOI: 10.1021/jm00047a020
BindingDB Entry DOI: 10.7270/Q2X34ZNN
More data for this
Ligand-Target Pair
TACR2


(mouse)
BDBM50407443
PNG
(CHEMBL267409)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(O)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCC(O)=O
Show InChI InChI=1S/C53H58N10O11/c1-28(2)47(63-52(73)44(22-32-26-57-40-14-8-5-11-36(32)40)61-50(71)41(19-29-15-17-33(64)18-16-29)59-48(69)37(54)23-45(65)66)53(74)62-43(21-31-25-56-39-13-7-4-10-35(31)39)51(72)60-42(49(70)58-27-46(67)68)20-30-24-55-38-12-6-3-9-34(30)38/h3-18,24-26,28,37,41-44,47,55-57,64H,19-23,27,54H2,1-2H3,(H,58,70)(H,59,69)(H,60,72)(H,61,71)(H,62,74)(H,63,73)(H,65,66)(H,67,68)/t37-,41-,42+,43+,44+,47-/m0/s1
Reactome pathway

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 34.7n/an/an/an/an/a



University of Illinois at Chicago

Curated by ChEMBL


Assay Description
Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)


J Med Chem 38: 2705-13 (1995)


Article DOI: 10.1021/jm00014a022
BindingDB Entry DOI: 10.7270/Q2GX4CSN
More data for this
Ligand-Target Pair
Neurokinin 2 receptor


(Oryctolagus cuniculus)
BDBM50407241
PNG
(CHEMBL433191)
Show SMILES CC(C)C[C@@H]1CN[C@@H](CC2CCCCC2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1
Show InChI InChI=1S/C43H60N8O6/c1-27(2)21-31-26-47-35(22-28-11-5-3-6-12-28)42(56)49-34(17-18-38(44)52)41(55)51-37(24-30-25-46-33-16-10-9-15-32(30)33)43(57)50-36(23-29-13-7-4-8-14-29)40(54)45-20-19-39(53)48-31/h4,7-10,13-16,25,27-28,31,34-37,46-47H,3,5-6,11-12,17-24,26H2,1-2H3,(H2,44,52)(H,45,54)(H,48,53)(H,49,56)(H,50,57)(H,51,55)/t31-,34-,35+,36-,37+/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 39n/an/an/an/an/a



A. Menarini Industrie Farmaceutiche Riunite

Curated by ChEMBL


Assay Description
Tested for agonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery at a concentration of 3-10 uM


J Med Chem 37: 3630-8 (1994)


Article DOI: 10.1021/jm00047a020
BindingDB Entry DOI: 10.7270/Q2X34ZNN
More data for this
Ligand-Target Pair
Neurokinin 2 receptor


(Oryctolagus cuniculus)
BDBM50407244
PNG
(CHEMBL121271)
Show SMILES CC(C)C[C@@H]1CN[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1
Show InChI InChI=1S/C47H56N8O6/c1-29(2)22-35-28-51-39(25-31-16-17-32-12-6-7-13-33(32)23-31)46(60)53-38(18-19-42(48)56)45(59)55-41(26-34-27-50-37-15-9-8-14-36(34)37)47(61)54-40(24-30-10-4-3-5-11-30)44(58)49-21-20-43(57)52-35/h3-17,23,27,29,35,38-41,50-51H,18-22,24-26,28H2,1-2H3,(H2,48,56)(H,49,58)(H,52,57)(H,53,60)(H,54,61)(H,55,59)/t35-,38-,39+,40-,41+/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 43n/an/an/an/an/a



A. Menarini Industrie Farmaceutiche Riunite

Curated by ChEMBL


Assay Description
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery


J Med Chem 37: 3630-8 (1994)


Article DOI: 10.1021/jm00047a020
BindingDB Entry DOI: 10.7270/Q2X34ZNN
More data for this
Ligand-Target Pair
Neurokinin 2 receptor


(GUINEA PIG)
BDBM50403557
PNG
(CHEMBL158318)
Show SMILES O=c1c2cnn(-c3ccccc3)c2nc2scc(-c3ccccc3)n12
Show InChI InChI=1S/C19H12N4OS/c24-18-15-11-20-23(14-9-5-2-6-10-14)17(15)21-19-22(18)16(12-25-19)13-7-3-1-4-8-13/h1-12H
UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem
Article
n/an/an/a 50n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for NK-2 receptor antagonistic activity in the guinea pig trachea


Bioorg Med Chem Lett 6: 59-64 (1996)


Article DOI: 10.1016/0960-894X(95)00558-B
BindingDB Entry DOI: 10.7270/Q2H13357
More data for this
Ligand-Target Pair
Substance-K receptor


(Homo sapiens (Human))
BDBM50106892
PNG
(3-[4-(3,4-dichlorophenyl)-3-[3,5-di(trifluoromethy...)
Show SMILES CN([C@H](Cc1ccc(Cl)c(Cl)c1)\C=C\C(=O)N[C@@H]1CCCCNC1=O)C(=O)c1cc(cc(c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C27H25Cl2F6N3O3/c1-38(25(41)16-12-17(26(30,31)32)14-18(13-16)27(33,34)35)19(10-15-5-7-20(28)21(29)11-15)6-8-23(39)37-22-4-2-3-9-36-24(22)40/h5-8,11-14,19,22H,2-4,9-10H2,1H3,(H,36,40)(H,37,39)/b8-6+/t19-,22+/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/a 53.7n/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
In vitro relative antagonist potency towards guinea pig Tachykinin receptor 2


J Med Chem 46: 3508-13 (2003)


Article DOI: 10.1021/jm030786m
BindingDB Entry DOI: 10.7270/Q21G0NGW
More data for this
Ligand-Target Pair
Neurokinin 2 receptor


(Oryctolagus cuniculus)
BDBM50407235
PNG
(CHEMBL331480)
Show SMILES CC(C)C[C@@H]1CN[C@@H](CCC(N)OCc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1
Show InChI InChI=1S/C46H61N9O7/c1-29(2)23-33-27-51-36(18-20-41(48)62-28-31-13-7-4-8-14-31)44(59)53-37(17-19-40(47)56)45(60)55-39(25-32-26-50-35-16-10-9-15-34(32)35)46(61)54-38(24-30-11-5-3-6-12-30)43(58)49-22-21-42(57)52-33/h3-16,26,29,33,36-39,41,50-51H,17-25,27-28,48H2,1-2H3,(H2,47,56)(H,49,58)(H,52,57)(H,53,59)(H,54,61)(H,55,60)/t33-,36+,37-,38-,39+,41?/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/a 54n/an/an/an/an/a



A. Menarini Industrie Farmaceutiche Riunite

Curated by ChEMBL


Assay Description
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery


J Med Chem 37: 3630-8 (1994)


Article DOI: 10.1021/jm00047a020
BindingDB Entry DOI: 10.7270/Q2X34ZNN
More data for this
Ligand-Target Pair
Neurokinin 2 receptor


(Oryctolagus cuniculus)
BDBM50407407
PNG
(CHEMBL407328)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(N)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O
Show InChI InChI=1S/C57H68N14O10/c1-30(2)49(71-54(78)47(25-34-29-65-42-15-8-5-12-38(34)42)69-51(75)44(22-31-17-19-35(72)20-18-31)67-50(74)39(58)26-48(59)73)55(79)70-46(24-33-28-64-41-14-7-4-11-37(33)41)53(77)68-45(23-32-27-63-40-13-6-3-10-36(32)40)52(76)66-43(56(80)81)16-9-21-62-57(60)61/h3-8,10-15,17-20,27-30,39,43-47,49,63-65,72H,9,16,21-26,58H2,1-2H3,(H2,59,73)(H,66,76)(H,67,74)(H,68,77)(H,69,75)(H,70,79)(H,71,78)(H,80,81)(H4,60,61,62)/t39-,43-,44-,45+,46+,47+,49-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 65n/an/an/an/an/a



University of Illinois at Chicago

Curated by ChEMBL


Assay Description
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.


J Med Chem 38: 2705-13 (1995)


Article DOI: 10.1021/jm00014a022
BindingDB Entry DOI: 10.7270/Q2GX4CSN
More data for this
Ligand-Target Pair
TACR2


(HAMSTER)
BDBM50407239
PNG
(CHEMBL332872)
Show SMILES CC(C)C[C@@H]1CN[C@@H](CC(O)=O)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1
Show InChI InChI=1S/C38H50N8O8/c1-22(2)16-25-21-42-29(19-34(49)50)37(53)44-28(12-13-32(39)47)36(52)46-31(18-24-20-41-27-11-7-6-10-26(24)27)38(54)45-30(17-23-8-4-3-5-9-23)35(51)40-15-14-33(48)43-25/h3-11,20,22,25,28-31,41-42H,12-19,21H2,1-2H3,(H2,39,47)(H,40,51)(H,43,48)(H,44,53)(H,45,54)(H,46,52)(H,49,50)/t25-,28-,29+,30-,31+/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 68n/an/an/an/an/a



A. Menarini Industrie Farmaceutiche Riunite

Curated by ChEMBL


Assay Description
Tested for antagonist activity at NK-2 tachykinin receptors in hamster trachea


J Med Chem 37: 3630-8 (1994)


Article DOI: 10.1021/jm00047a020
BindingDB Entry DOI: 10.7270/Q2X34ZNN
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 1468 total )  |  Next  |  Last  >>
Jump to: