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Compile Data Set for Download or QSAR

Found 3591 hits Enz. Inhib. hit(s) with Target = 'Nicotinamide phosphoribosyltransferase'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM50448644
PNG
(CHEMBL3127513)
Show SMILES O=C(NCc1ccc(cc1)S(=O)(=O)N1CCN(CC1)C1COC1)c1cc2ccncc2o1
Show InChI InChI=1S/C22H24N4O5S/c27-22(20-11-17-5-6-23-13-21(17)31-20)24-12-16-1-3-19(4-2-16)32(28,29)26-9-7-25(8-10-26)18-14-30-15-18/h1-6,11,13,18H,7-10,12,14-15H2,(H,24,27)
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n/an/an/a 80n/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Binding affinity to NAMPT (2 to 491) (unknown origin) by surface plasmon resonance analysis


J Med Chem 57: 770-92 (2014)


Article DOI: 10.1021/jm4015108
BindingDB Entry DOI: 10.7270/Q2BC412B
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM50448645
PNG
(CHEMBL3127512)
Show SMILES O=C(NCCCCS(=O)(=O)c1ccccc1)c1ccc2nccn2c1
Show InChI InChI=1S/C18H19N3O3S/c22-18(15-8-9-17-19-11-12-21(17)14-15)20-10-4-5-13-25(23,24)16-6-2-1-3-7-16/h1-3,6-9,11-12,14H,4-5,10,13H2,(H,20,22)
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n/an/an/a 860n/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Binding affinity to NAMPT (2 to 491) (unknown origin) by surface plasmon resonance analysis


J Med Chem 57: 770-92 (2014)


Article DOI: 10.1021/jm4015108
BindingDB Entry DOI: 10.7270/Q2BC412B
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM50447577
PNG
(CHEMBL1494030)
Show SMILES Cn1nccc1C(=O)Nc1cccnc1
Show InChI InChI=1S/C10H10N4O/c1-14-9(4-6-12-14)10(15)13-8-3-2-5-11-7-8/h2-7H,1H3,(H,13,15)
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n/an/an/a 5.20E+3n/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal His6-tagged/biotinylated C-terminal Avi-tagged human NAMPT (2 to 491) by SPR analysis


Bioorg Med Chem Lett 24: 954-62 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.062
BindingDB Entry DOI: 10.7270/Q2RV0Q50
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM51526
PNG
(6-[(dimethylamino)methyl]-4-ethyl-7-hydroxy-8-meth...)
Show SMILES CCc1cc(=O)oc2c(C)c(O)c(CN(C)C)cc12
Show InChI InChI=1S/C15H19NO3/c1-5-10-7-13(17)19-15-9(2)14(18)11(6-12(10)15)8-16(3)4/h6-7,18H,5,8H2,1-4H3
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n/an/an/a 1.20E+4n/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal His6-tagged/biotinylated C-terminal Avi-tagged human NAMPT (2 to 491) by SPR analysis


Bioorg Med Chem Lett 24: 954-62 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.062
BindingDB Entry DOI: 10.7270/Q2RV0Q50
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM50447569
PNG
(CHEMBL3112697)
Show SMILES Cc1ccoc1C(=O)Nc1cccnc1
Show InChI InChI=1S/C11H10N2O2/c1-8-4-6-15-10(8)11(14)13-9-3-2-5-12-7-9/h2-7H,1H3,(H,13,14)
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n/an/an/a 1.30E+4n/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal His6-tagged/biotinylated C-terminal Avi-tagged human NAMPT (2 to 491) by SPR analysis


Bioorg Med Chem Lett 24: 954-62 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.062
BindingDB Entry DOI: 10.7270/Q2RV0Q50
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM50448640
PNG
(CHEMBL3127519)
Show SMILES O=C(Nc1ccncc1)[C@@H]1C[C@H]1c1ccccc1
Show InChI InChI=1/C15H14N2O/c18-15(17-12-6-8-16-9-7-12)14-10-13(14)11-4-2-1-3-5-11/h1-9,13-14H,10H2,(H,16,17,18)/t13-,14+/s2
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n/an/an/a 1.70E+4n/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Binding affinity to NAMPT (2 to 491) (unknown origin) by surface plasmon resonance analysis


J Med Chem 57: 770-92 (2014)


Article DOI: 10.1021/jm4015108
BindingDB Entry DOI: 10.7270/Q2BC412B
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM50447570
PNG
(CHEMBL3112696)
Show SMILES Cc1ncsc1C(=O)Nc1cccnc1
Show InChI InChI=1S/C10H9N3OS/c1-7-9(15-6-12-7)10(14)13-8-3-2-4-11-5-8/h2-6H,1H3,(H,13,14)
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n/an/an/a 2.00E+4n/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal His6-tagged/biotinylated C-terminal Avi-tagged human NAMPT (2 to 491) by SPR analysis


Bioorg Med Chem Lett 24: 954-62 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.062
BindingDB Entry DOI: 10.7270/Q2RV0Q50
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM50447574
PNG
(CHEMBL3112692)
Show SMILES Cc1sccc1C(=O)Nc1cccnc1
Show InChI InChI=1S/C11H10N2OS/c1-8-10(4-6-15-8)11(14)13-9-3-2-5-12-7-9/h2-7H,1H3,(H,13,14)
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n/an/an/a 3.60E+4n/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal His6-tagged/biotinylated C-terminal Avi-tagged human NAMPT (2 to 491) by SPR analysis


Bioorg Med Chem Lett 24: 954-62 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.062
BindingDB Entry DOI: 10.7270/Q2RV0Q50
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM50439681
PNG
(CHEMBL2417797)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)[n+]1cccc(\C=C\C(=O)NCCCCC2CCN(CC2)C(=O)c2ccccc2)c1
Show InChI InChI=1/C29H37N3O6/c33-20-24-26(35)27(36)29(38-24)32-16-6-8-22(19-32)11-12-25(34)30-15-5-4-7-21-13-17-31(18-14-21)28(37)23-9-2-1-3-10-23/h1-3,6,8-12,16,19,21,24,26-27,29,33,35-36H,4-5,7,13-15,17-18,20H2/p+1/b12-11+/t24-,26-,27-,29-/s2
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n/an/an/a 4.50E+4n/an/an/an/an/a



Universit£ degli Studi del Piemonte Orientale"A. Avogadro"

Curated by ChEMBL


Assay Description
Binding affinity to NAMPT (unknown origin)


J Med Chem 56: 6279-96 (2013)


Article DOI: 10.1021/jm4001049
BindingDB Entry DOI: 10.7270/Q25Q4XJ8
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM50448646
PNG
(CHEMBL3127517)
Show SMILES [O-][N+](=O)c1ccc(NC(=O)C2CC2)cc1
Show InChI InChI=1S/C10H10N2O3/c13-10(7-1-2-7)11-8-3-5-9(6-4-8)12(14)15/h3-7H,1-2H2,(H,11,13)
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n/an/an/a 5.10E+4n/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Binding affinity to NAMPT (2 to 491) (unknown origin) by surface plasmon resonance analysis


J Med Chem 57: 770-92 (2014)


Article DOI: 10.1021/jm4015108
BindingDB Entry DOI: 10.7270/Q2BC412B
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM50447573
PNG
(CHEMBL3112693)
Show SMILES Cc1scnc1C(=O)Nc1cccnc1
Show InChI InChI=1S/C10H9N3OS/c1-7-9(12-6-15-7)10(14)13-8-3-2-4-11-5-8/h2-6H,1H3,(H,13,14)
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n/an/an/a 5.50E+4n/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal His6-tagged/biotinylated C-terminal Avi-tagged human NAMPT (2 to 491) by SPR analysis


Bioorg Med Chem Lett 24: 954-62 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.062
BindingDB Entry DOI: 10.7270/Q2RV0Q50
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM50447564
PNG
(CHEMBL3112702)
Show SMILES Cc1nn(C)cc1C(=O)Nc1cccnc1
Show InChI InChI=1S/C11H12N4O/c1-8-10(7-15(2)14-8)11(16)13-9-4-3-5-12-6-9/h3-7H,1-2H3,(H,13,16)
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n/an/an/a 5.90E+4n/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal His6-tagged/biotinylated C-terminal Avi-tagged human NAMPT (2 to 491) by SPR analysis


Bioorg Med Chem Lett 24: 954-62 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.062
BindingDB Entry DOI: 10.7270/Q2RV0Q50
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM50447572
PNG
(CHEMBL3112694)
Show SMILES Cc1ocnc1C(=O)Nc1cccnc1
Show InChI InChI=1S/C10H9N3O2/c1-7-9(12-6-15-7)10(14)13-8-3-2-4-11-5-8/h2-6H,1H3,(H,13,14)
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n/an/an/a 6.10E+4n/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal His6-tagged/biotinylated C-terminal Avi-tagged human NAMPT (2 to 491) by SPR analysis


Bioorg Med Chem Lett 24: 954-62 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.062
BindingDB Entry DOI: 10.7270/Q2RV0Q50
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM50448647
PNG
(CHEMBL3127516)
Show SMILES CC(=O)Nc1ccc(NC(=O)C2CC2)cc1
Show InChI InChI=1S/C12H14N2O2/c1-8(15)13-10-4-6-11(7-5-10)14-12(16)9-2-3-9/h4-7,9H,2-3H2,1H3,(H,13,15)(H,14,16)
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n/an/an/a 7.80E+4n/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Binding affinity to NAMPT (2 to 491) (unknown origin) by surface plasmon resonance analysis


J Med Chem 57: 770-92 (2014)


Article DOI: 10.1021/jm4015108
BindingDB Entry DOI: 10.7270/Q2BC412B
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM50208881
PNG
(5-Nitro-1H-benzoimidazole | 5-nitrobenzimidazole |...)
Show SMILES [O-][N+](=O)c1ccc2nc[nH]c2c1
Show InChI InChI=1S/C7H5N3O2/c11-10(12)5-1-2-6-7(3-5)9-4-8-6/h1-4H,(H,8,9)
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n/an/an/a 1.26E+5n/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal His6-tagged/biotinylated C-terminal Avi-tagged human NAMPT (2 to 491) by SPR analysis


Bioorg Med Chem Lett 24: 954-62 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.062
BindingDB Entry DOI: 10.7270/Q2RV0Q50
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM50447575
PNG
(CHEMBL3112691)
Show SMILES Cn1ccnc1C(=O)Nc1cccnc1
Show InChI InChI=1S/C10H10N4O/c1-14-6-5-12-9(14)10(15)13-8-3-2-4-11-7-8/h2-7H,1H3,(H,13,15)
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n/an/an/a 1.29E+5n/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal His6-tagged/biotinylated C-terminal Avi-tagged human NAMPT (2 to 491) by SPR analysis


Bioorg Med Chem Lett 24: 954-62 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.062
BindingDB Entry DOI: 10.7270/Q2RV0Q50
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM50447571
PNG
(CHEMBL3112695)
Show SMILES Cc1ccsc1C(=O)Nc1cccnc1
Show InChI InChI=1S/C11H10N2OS/c1-8-4-6-15-10(8)11(14)13-9-3-2-5-12-7-9/h2-7H,1H3,(H,13,14)
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n/an/an/a 1.29E+5n/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal His6-tagged/biotinylated C-terminal Avi-tagged human NAMPT (2 to 491) by SPR analysis


Bioorg Med Chem Lett 24: 954-62 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.062
BindingDB Entry DOI: 10.7270/Q2RV0Q50
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM50447576
PNG
(CHEMBL3116433)
Show SMILES O=C(Nc1cccnc1)c1ccn[nH]1
Show InChI InChI=1S/C9H8N4O/c14-9(8-3-5-11-13-8)12-7-2-1-4-10-6-7/h1-6H,(H,11,13)(H,12,14)
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n/an/an/a 1.76E+5n/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal His6-tagged/biotinylated C-terminal Avi-tagged human NAMPT (2 to 491) by SPR analysis


Bioorg Med Chem Lett 24: 954-62 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.062
BindingDB Entry DOI: 10.7270/Q2RV0Q50
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM50447566
PNG
(CHEMBL3112700)
Show SMILES Cc1c(cnn1-c1ccccc1)C(=O)Nc1cccnc1
Show InChI InChI=1S/C16H14N4O/c1-12-15(16(21)19-13-6-5-9-17-10-13)11-18-20(12)14-7-3-2-4-8-14/h2-11H,1H3,(H,19,21)
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n/an/an/a 1.77E+5n/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal His6-tagged/biotinylated C-terminal Avi-tagged human NAMPT (2 to 491) by SPR analysis


Bioorg Med Chem Lett 24: 954-62 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.062
BindingDB Entry DOI: 10.7270/Q2RV0Q50
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM86248
PNG
(CAS_364-98-7 | DIAZOXIDE | NSC_3019 | diazoxide)
Show SMILES CC1=Nc2ccc(Cl)cc2S(=O)(=O)N1
Show InChI InChI=1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11)
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n/an/an/a 2.30E+5n/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Binding affinity to NAMPT (2 to 491) (unknown origin) by surface plasmon resonance analysis


J Med Chem 57: 770-92 (2014)


Article DOI: 10.1021/jm4015108
BindingDB Entry DOI: 10.7270/Q2BC412B
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM50447563
PNG
(CHEMBL3112703)
Show SMILES CCn1cc(C(=O)Nc2cccnc2)c(C)n1
Show InChI InChI=1S/C12H14N4O/c1-3-16-8-11(9(2)15-16)12(17)14-10-5-4-6-13-7-10/h4-8H,3H2,1-2H3,(H,14,17)
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n/an/an/a 2.33E+5n/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal His6-tagged/biotinylated C-terminal Avi-tagged human NAMPT (2 to 491) by SPR analysis


Bioorg Med Chem Lett 24: 954-62 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.062
BindingDB Entry DOI: 10.7270/Q2RV0Q50
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM50447568
PNG
(CHEMBL3112698)
Show SMILES Cc1ccc(C(=O)Nc2cccnc2)n1C
Show InChI InChI=1S/C12H13N3O/c1-9-5-6-11(15(9)2)12(16)14-10-4-3-7-13-8-10/h3-8H,1-2H3,(H,14,16)
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n/an/an/a 2.34E+5n/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal His6-tagged/biotinylated C-terminal Avi-tagged human NAMPT (2 to 491) by SPR analysis


Bioorg Med Chem Lett 24: 954-62 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.062
BindingDB Entry DOI: 10.7270/Q2RV0Q50
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM50447562
PNG
(CHEMBL3112704)
Show SMILES CCc1cc(C(=O)Nc2cccnc2)n(C)n1
Show InChI InChI=1S/C12H14N4O/c1-3-9-7-11(16(2)15-9)12(17)14-10-5-4-6-13-8-10/h4-8H,3H2,1-2H3,(H,14,17)
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n/an/an/a 4.81E+5n/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal His6-tagged/biotinylated C-terminal Avi-tagged human NAMPT (2 to 491) by SPR analysis


Bioorg Med Chem Lett 24: 954-62 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.062
BindingDB Entry DOI: 10.7270/Q2RV0Q50
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM50447565
PNG
(CHEMBL3112701)
Show SMILES Cc1ncc(C(=O)Nc2cccnc2)n1C
Show InChI InChI=1S/C11H12N4O/c1-8-13-7-10(15(8)2)11(16)14-9-4-3-5-12-6-9/h3-7H,1-2H3,(H,14,16)
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n/an/an/a>5.00E+5n/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal His6-tagged/biotinylated C-terminal Avi-tagged human NAMPT (2 to 491) by SPR analysis


Bioorg Med Chem Lett 24: 954-62 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.062
BindingDB Entry DOI: 10.7270/Q2RV0Q50
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM50448641
PNG
(CHEMBL3127518)
Show SMILES O=C(Nc1ccncc1)C1CC1
Show InChI InChI=1S/C9H10N2O/c12-9(7-1-2-7)11-8-3-5-10-6-4-8/h3-7H,1-2H2,(H,10,11,12)
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n/an/an/a>5.00E+5n/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Binding affinity to NAMPT (2 to 491) (unknown origin) by surface plasmon resonance analysis


J Med Chem 57: 770-92 (2014)


Article DOI: 10.1021/jm4015108
BindingDB Entry DOI: 10.7270/Q2BC412B
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM50447567
PNG
(CHEMBL3112699)
Show SMILES CCn1ncc(C(=O)Nc2cccnc2)c1C
Show InChI InChI=1S/C12H14N4O/c1-3-16-9(2)11(8-14-16)12(17)15-10-5-4-6-13-7-10/h4-8H,3H2,1-2H3,(H,15,17)
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n/an/an/a>5.00E+5n/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal His6-tagged/biotinylated C-terminal Avi-tagged human NAMPT (2 to 491) by SPR analysis


Bioorg Med Chem Lett 24: 954-62 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.062
BindingDB Entry DOI: 10.7270/Q2RV0Q50
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM81395
PNG
(APO-866)
Show SMILES O=C(NCCCCC1CCN(CC1)C(=O)c1ccccc1)\C=C\c1cccnc1
Show InChI InChI=1S/C24H29N3O2/c28-23(12-11-21-8-6-15-25-19-21)26-16-5-4-7-20-13-17-27(18-14-20)24(29)22-9-2-1-3-10-22/h1-3,6,8-12,15,19-20H,4-5,7,13-14,16-18H2,(H,26,28)/b12-11+
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0.300n/an/an/an/an/an/an/an/a



Universit£ degli Studi del Piemonte Orientale"A. Avogadro"

Curated by ChEMBL


Assay Description
Noncompetitive inhibition of NAMPT (unknown origin)


J Med Chem 56: 6279-96 (2013)


Article DOI: 10.1021/jm4001049
BindingDB Entry DOI: 10.7270/Q25Q4XJ8
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM217112
PNG
(US9302989, 407)
Show SMILES O=C(Nc1ccc(cc1)C1CCN(CC1)C(=O)c1ccccc1)N1Cc2ccccc2C1
Show InChI InChI=1S/C27H27N3O2/c31-26(22-6-2-1-3-7-22)29-16-14-21(15-17-29)20-10-12-25(13-11-20)28-27(32)30-18-23-8-4-5-9-24(23)19-30/h1-13,21H,14-19H2,(H,28,32)
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1n/an/an/an/an/an/an/an/a



AbbVie Inc

Curated by ChEMBL


Assay Description
Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...


Bioorg Med Chem Lett 27: 3317-3325 (2017)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM50254198
PNG
(CHEMBL4060799)
Show SMILES CN1CCN(CC1)C(C)(C)C(=O)N1CCC(CC1)c1ccc(NC(=O)N2Cc3ccccc3C2)cc1
Show InChI InChI=1S/C29H39N5O2/c1-29(2,34-18-16-31(3)17-19-34)27(35)32-14-12-23(13-15-32)22-8-10-26(11-9-22)30-28(36)33-20-24-6-4-5-7-25(24)21-33/h4-11,23H,12-21H2,1-3H3,(H,30,36)
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1.5n/an/an/an/an/an/an/an/a



AbbVie Inc

Curated by ChEMBL


Assay Description
Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...


Bioorg Med Chem Lett 27: 3317-3325 (2017)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM217057
PNG
(US9302989, 349)
Show SMILES O=C(NCCCCC1CCN(CC1)C(=O)c1ccccc1)N1Cc2ccccc2C1
Show InChI InChI=1S/C25H31N3O2/c29-24(21-9-2-1-3-10-21)27-16-13-20(14-17-27)8-6-7-15-26-25(30)28-18-22-11-4-5-12-23(22)19-28/h1-5,9-12,20H,6-8,13-19H2,(H,26,30)
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1.60n/an/an/an/an/an/an/an/a



AbbVie Inc

Curated by ChEMBL


Assay Description
Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...


Bioorg Med Chem Lett 27: 3317-3325 (2017)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM50254199
PNG
(CHEMBL4083505)
Show SMILES Clc1ccc2CN(Cc2c1)C(=O)Nc1ccc(cc1)C1CCN(CC1)C(=O)[C@@H]1CCCO1
Show InChI InChI=1/C25H28ClN3O3/c26-21-6-3-19-15-29(16-20(19)14-21)25(31)27-22-7-4-17(5-8-22)18-9-11-28(12-10-18)24(30)23-2-1-13-32-23/h3-8,14,18,23H,1-2,9-13,15-16H2,(H,27,31)/t23-/s2
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1.70n/an/an/an/an/an/an/an/a



AbbVie Inc

Curated by ChEMBL


Assay Description
Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...


Bioorg Med Chem Lett 27: 3317-3325 (2017)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM50254216
PNG
(CHEMBL4096471)
Show SMILES Fc1ccc2CN(Cc2c1)C(=O)Nc1ccc(cc1)C1CN(C1)C(=O)c1ccccc1
Show InChI InChI=1S/C25H22FN3O2/c26-22-9-6-19-13-29(14-20(19)12-22)25(31)27-23-10-7-17(8-11-23)21-15-28(16-21)24(30)18-4-2-1-3-5-18/h1-12,21H,13-16H2,(H,27,31)
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1.90n/an/an/an/an/an/an/an/a



AbbVie Inc

Curated by ChEMBL


Assay Description
Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...


Bioorg Med Chem Lett 27: 3317-3325 (2017)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM50254215
PNG
(CHEMBL4089003)
Show SMILES CC(C)(O)CC(=O)N1CCC(CC1)c1ccc(NC(=O)N2Cc3ccc(F)cc3C2)cc1
Show InChI InChI=1S/C25H30FN3O3/c1-25(2,32)14-23(30)28-11-9-18(10-12-28)17-4-7-22(8-5-17)27-24(31)29-15-19-3-6-21(26)13-20(19)16-29/h3-8,13,18,32H,9-12,14-16H2,1-2H3,(H,27,31)
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2.5n/an/an/an/an/an/an/an/a



AbbVie Inc

Curated by ChEMBL


Assay Description
Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...


Bioorg Med Chem Lett 27: 3317-3325 (2017)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM81395
PNG
(APO-866)
Show SMILES O=C(NCCCCC1CCN(CC1)C(=O)c1ccccc1)\C=C\c1cccnc1
Show InChI InChI=1S/C24H29N3O2/c28-23(12-11-21-8-6-15-25-19-21)26-16-5-4-7-20-13-17-27(18-14-20)24(29)22-9-2-1-3-10-22/h1-3,6,8-12,15,19-20H,4-5,7,13-14,16-18H2,(H,26,28)/b12-11+
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3n/an/an/an/an/an/an/an/a



AbbVie Inc

Curated by ChEMBL


Assay Description
Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...


Bioorg Med Chem Lett 27: 3317-3325 (2017)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM217040
PNG
(US9302989, 332)
Show SMILES O=C(Nc1ccc(cc1)C1=CCN(CC1)C(=O)c1ccccc1)N1Cc2ccccc2C1
Show InChI InChI=1S/C27H25N3O2/c31-26(22-6-2-1-3-7-22)29-16-14-21(15-17-29)20-10-12-25(13-11-20)28-27(32)30-18-23-8-4-5-9-24(23)19-30/h1-14H,15-19H2,(H,28,32)
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3n/an/an/an/an/an/an/an/a



AbbVie Inc

Curated by ChEMBL


Assay Description
Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...


Bioorg Med Chem Lett 27: 3317-3325 (2017)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM50435350
PNG
(CHEMBL17289)
Show SMILES Clc1ccc(OCCCCCCNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C19H22ClN5O/c20-16-5-7-18(8-6-16)26-14-4-2-1-3-11-23-19(24-15-21)25-17-9-12-22-13-10-17/h5-10,12-13H,1-4,11,14H2,(H2,22,23,24,25)
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3n/an/an/an/an/an/an/an/a



AbbVie Inc

Curated by ChEMBL


Assay Description
Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...


Bioorg Med Chem Lett 27: 3317-3325 (2017)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM50254212
PNG
(CHEMBL4076064)
Show SMILES Fc1ccc2CN(Cc2c1)C(=O)Nc1ccc(cc1)C1CCN(CC1)S(=O)(=O)C1CC1
Show InChI InChI=1S/C23H26FN3O3S/c24-20-4-1-18-14-26(15-19(18)13-20)23(28)25-21-5-2-16(3-6-21)17-9-11-27(12-10-17)31(29,30)22-7-8-22/h1-6,13,17,22H,7-12,14-15H2,(H,25,28)
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3.90n/an/an/an/an/an/an/an/a



AbbVie Inc

Curated by ChEMBL


Assay Description
Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...


Bioorg Med Chem Lett 27: 3317-3325 (2017)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM50254192
PNG
(CHEMBL4105475)
Show SMILES CC1(CC1)C(=O)N1CCC(CC1)c1ccc(NC(=O)N2Cc3ccccc3C2)cc1
Show InChI InChI=1S/C25H29N3O2/c1-25(12-13-25)23(29)27-14-10-19(11-15-27)18-6-8-22(9-7-18)26-24(30)28-16-20-4-2-3-5-21(20)17-28/h2-9,19H,10-17H2,1H3,(H,26,30)
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4.30n/an/an/an/an/an/an/an/a



AbbVie Inc

Curated by ChEMBL


Assay Description
Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...


Bioorg Med Chem Lett 27: 3317-3325 (2017)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM215830
PNG
(US9302989, 25)
Show SMILES CC(C)CCNC(=O)c1ccc(NC(=O)N2Cc3ccc(cc3C2)C#N)cc1
Show InChI InChI=1S/C22H24N4O2/c1-15(2)9-10-24-21(27)17-5-7-20(8-6-17)25-22(28)26-13-18-4-3-16(12-23)11-19(18)14-26/h3-8,11,15H,9-10,13-14H2,1-2H3,(H,24,27)(H,25,28)
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4.70n/an/an/an/an/an/an/an/a



AbbVie Inc

Curated by ChEMBL


Assay Description
Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...


Bioorg Med Chem Lett 27: 3317-3325 (2017)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM217170
PNG
(US9302989, 608)
Show SMILES CC(C)CCNC(=O)c1ccc(NC(=O)N2Cc3ccc(CO)cc3C2)cc1
Show InChI InChI=1S/C22H27N3O3/c1-15(2)9-10-23-21(27)17-5-7-20(8-6-17)24-22(28)25-12-18-4-3-16(14-26)11-19(18)13-25/h3-8,11,15,26H,9-10,12-14H2,1-2H3,(H,23,27)(H,24,28)
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4.90n/an/an/an/an/an/an/an/a



AbbVie Inc

Curated by ChEMBL


Assay Description
Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...


Bioorg Med Chem Lett 27: 3317-3325 (2017)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM50254214
PNG
(CHEMBL4086819)
Show SMILES CC1(COC1)C(=O)N1CCC(CC1)c1ccc(NC(=O)N2Cc3ccccc3C2)cc1
Show InChI InChI=1S/C25H29N3O3/c1-25(16-31-17-25)23(29)27-12-10-19(11-13-27)18-6-8-22(9-7-18)26-24(30)28-14-20-4-2-3-5-21(20)15-28/h2-9,19H,10-17H2,1H3,(H,26,30)
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5.10n/an/an/an/an/an/an/an/a



AbbVie Inc

Curated by ChEMBL


Assay Description
Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...


Bioorg Med Chem Lett 27: 3317-3325 (2017)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM217078
PNG
(US9302989, 370)
Show SMILES CC(C)CCNC(=O)c1ccc(NC(=O)N2Cc3ccccc3C2)nc1
Show InChI InChI=1S/C20H24N4O2/c1-14(2)9-10-21-19(25)15-7-8-18(22-11-15)23-20(26)24-12-16-5-3-4-6-17(16)13-24/h3-8,11,14H,9-10,12-13H2,1-2H3,(H,21,25)(H,22,23,26)
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5.40n/an/an/an/an/an/an/an/a



AbbVie Inc

Curated by ChEMBL


Assay Description
Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...


Bioorg Med Chem Lett 27: 3317-3325 (2017)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM50254184
PNG
(CHEMBL4082366)
Show SMILES CC(C)(O)CC(=O)N1CCC(CC1)c1ccc(NC(=O)N2Cc3ccccc3C2)cc1
Show InChI InChI=1S/C25H31N3O3/c1-25(2,31)15-23(29)27-13-11-19(12-14-27)18-7-9-22(10-8-18)26-24(30)28-16-20-5-3-4-6-21(20)17-28/h3-10,19,31H,11-17H2,1-2H3,(H,26,30)
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5.60n/an/an/an/an/an/an/an/a



AbbVie Inc

Curated by ChEMBL


Assay Description
Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...


Bioorg Med Chem Lett 27: 3317-3325 (2017)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM216345
PNG
(US9302989, 290)
Show SMILES CC(C)CCNC(=O)c1ccc(NC(=O)N2Cc3ccncc3C2)cc1
Show InChI InChI=1S/C20H24N4O2/c1-14(2)7-10-22-19(25)15-3-5-18(6-4-15)23-20(26)24-12-16-8-9-21-11-17(16)13-24/h3-6,8-9,11,14H,7,10,12-13H2,1-2H3,(H,22,25)(H,23,26)
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7.5n/an/an/an/an/an/an/an/a



AbbVie Inc

Curated by ChEMBL


Assay Description
Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...


Bioorg Med Chem Lett 27: 3317-3325 (2017)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM215825
PNG
(US9302989, 20)
Show SMILES CC(C)CCNC(=O)c1ccc(NC(=O)N2Cc3ccc(F)cc3C2)cc1
Show InChI InChI=1S/C21H24FN3O2/c1-14(2)9-10-23-20(26)15-4-7-19(8-5-15)24-21(27)25-12-16-3-6-18(22)11-17(16)13-25/h3-8,11,14H,9-10,12-13H2,1-2H3,(H,23,26)(H,24,27)
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7.90n/an/an/an/an/an/an/an/a



AbbVie Inc

Curated by ChEMBL


Assay Description
Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...


Bioorg Med Chem Lett 27: 3317-3325 (2017)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM215806
PNG
(US9302989, 1)
Show SMILES O=C(Nc1ccc(cc1)C(=O)NCCCc1ccccc1)N1Cc2ccccc2C1
Show InChI InChI=1S/C25H25N3O2/c29-24(26-16-6-9-19-7-2-1-3-8-19)20-12-14-23(15-13-20)27-25(30)28-17-21-10-4-5-11-22(21)18-28/h1-5,7-8,10-15H,6,9,16-18H2,(H,26,29)(H,27,30)
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9n/an/an/an/an/an/an/an/a



AbbVie Inc

Curated by ChEMBL


Assay Description
Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...


Bioorg Med Chem Lett 27: 3317-3325 (2017)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM50254197
PNG
(CHEMBL4077485)
Show SMILES CN1CCC(CC1)C(=O)N1CCC(CC1)c1ccc(NC(=O)N2Cc3ccc(F)cc3C2)cc1
Show InChI InChI=1S/C27H33FN4O2/c1-30-12-8-21(9-13-30)26(33)31-14-10-20(11-15-31)19-3-6-25(7-4-19)29-27(34)32-17-22-2-5-24(28)16-23(22)18-32/h2-7,16,20-21H,8-15,17-18H2,1H3,(H,29,34)
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9.40n/an/an/an/an/an/an/an/a



AbbVie Inc

Curated by ChEMBL


Assay Description
Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...


Bioorg Med Chem Lett 27: 3317-3325 (2017)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM215841
PNG
(US9302989, 36)
Show SMILES CC(C)CCNC(=O)c1ccc(NC(=O)N2Cc3ccccc3C2)cc1
Show InChI InChI=1S/C21H25N3O2/c1-15(2)11-12-22-20(25)16-7-9-19(10-8-16)23-21(26)24-13-17-5-3-4-6-18(17)14-24/h3-10,15H,11-14H2,1-2H3,(H,22,25)(H,23,26)
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11n/an/an/an/an/an/an/an/a



AbbVie Inc

Curated by ChEMBL


Assay Description
Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...


Bioorg Med Chem Lett 27: 3317-3325 (2017)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM215848
PNG
(US9302989, 43)
Show SMILES CC(C)CCNC(=O)c1ccc(NC(=O)N2Cc3ccc(C)cc3C2)cc1
Show InChI InChI=1S/C22H27N3O2/c1-15(2)10-11-23-21(26)17-6-8-20(9-7-17)24-22(27)25-13-18-5-4-16(3)12-19(18)14-25/h4-9,12,15H,10-11,13-14H2,1-3H3,(H,23,26)(H,24,27)
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13n/an/an/an/an/an/an/an/a



AbbVie Inc

Curated by ChEMBL


Assay Description
Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...


Bioorg Med Chem Lett 27: 3317-3325 (2017)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM216082
PNG
(US9302989, 420)
Show SMILES O=C(Nc1ccc(cc1)C(=O)NCC1CCCOC1)N1Cc2ccccc2C1
Show InChI InChI=1/C22H25N3O3/c26-21(23-12-16-4-3-11-28-15-16)17-7-9-20(10-8-17)24-22(27)25-13-18-5-1-2-6-19(18)14-25/h1-2,5-10,16H,3-4,11-15H2,(H,23,26)(H,24,27)
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13n/an/an/an/an/an/an/an/a



AbbVie Inc

Curated by ChEMBL


Assay Description
Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...


Bioorg Med Chem Lett 27: 3317-3325 (2017)

More data for this
Ligand-Target Pair
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