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Found 46 hits Enz. Inhib. hit(s) with Target = 'O-GlcNAc Transferase (OGT)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
O-GlcNAc Transferase (OGT)


(Homo sapiens (Human))
BDBM147133
PNG
(US8957075, Table 1 Compound 28)
Show SMILES O=C(C(NS(=O)(=O)c1ccc2[nH]c(=O)ccc2c1)c1ccccc1)N(Cc1ccco1)Cc1cccs1
Show InChI InChI=1S/C27H23N3O5S2/c31-25-13-10-20-16-23(11-12-24(20)28-25)37(33,34)29-26(19-6-2-1-3-7-19)27(32)30(17-21-8-4-14-35-21)18-22-9-5-15-36-22/h1-16,26,29H,17-18H2,(H,28,31)
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n/an/an/a 400n/an/an/an/an/a



President and Fellows of Harvard College

US Patent


Assay Description
384-well plates (Costar #3654) were filled using a liquid handling robot with 20 uL of a mixture of 50 nM of a fluorescein-linked UDP-GlcNAc analog (...


US Patent US8957075 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B82
More data for this
Ligand-Target Pair
O-GlcNAc Transferase (OGT)


(Homo sapiens (Human))
BDBM147117
PNG
(US8957075, Table 1 Compound 12)
Show SMILES CC(N(Cc1ccco1)C(=O)C(NS(=O)(=O)c1ccc2NC(=O)CCc2c1)c1ccccc1)c1cccs1
Show InChI InChI=1S/C28H27N3O5S2/c1-19(25-10-6-16-37-25)31(18-22-9-5-15-36-22)28(33)27(20-7-3-2-4-8-20)30-38(34,35)23-12-13-24-21(17-23)11-14-26(32)29-24/h2-10,12-13,15-17,19,27,30H,11,14,18H2,1H3,(H,29,32)
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n/an/an/a 1.60E+3n/an/an/an/an/a



President and Fellows of Harvard College

US Patent


Assay Description
384-well plates (Costar #3654) were filled using a liquid handling robot with 20 uL of a mixture of 50 nM of a fluorescein-linked UDP-GlcNAc analog (...


US Patent US8957075 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B82
More data for this
Ligand-Target Pair
O-GlcNAc Transferase (OGT)


(Homo sapiens (Human))
BDBM147110
PNG
(US8957075, Table 1 Compound 4)
Show SMILES O=C(C(NS(=O)(=O)c1ccc2NC(=O)CCc2c1)c1ccccc1)N1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C29H31N3O4S/c33-27-14-11-24-20-25(12-13-26(24)30-27)37(35,36)31-28(23-9-5-2-6-10-23)29(34)32-17-15-22(16-18-32)19-21-7-3-1-4-8-21/h1-10,12-13,20,22,28,31H,11,14-19H2,(H,30,33)
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n/an/an/a 2.00E+3n/an/an/an/an/a



President and Fellows of Harvard College

US Patent


Assay Description
384-well plates (Costar #3654) were filled using a liquid handling robot with 20 uL of a mixture of 50 nM of a fluorescein-linked UDP-GlcNAc analog (...


US Patent US8957075 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B82
More data for this
Ligand-Target Pair
O-GlcNAc Transferase (OGT)


(Homo sapiens (Human))
BDBM147116
PNG
(US8957075, Table 1 Compound 11)
Show SMILES CC1CN(CCN1c1ccc(C)cc1)C(=O)C(NS(=O)(=O)c1ccc2NC(=O)CCc2c1)c1ccccc1
Show InChI InChI=1S/C29H32N4O4S/c1-20-8-11-24(12-9-20)33-17-16-32(19-21(33)2)29(35)28(22-6-4-3-5-7-22)31-38(36,37)25-13-14-26-23(18-25)10-15-27(34)30-26/h3-9,11-14,18,21,28,31H,10,15-17,19H2,1-2H3,(H,30,34)
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n/an/an/a 3.20E+3n/an/an/an/an/a



President and Fellows of Harvard College

US Patent


Assay Description
384-well plates (Costar #3654) were filled using a liquid handling robot with 20 uL of a mixture of 50 nM of a fluorescein-linked UDP-GlcNAc analog (...


US Patent US8957075 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B82
More data for this
Ligand-Target Pair
O-GlcNAc Transferase (OGT)


(Homo sapiens (Human))
BDBM147132
PNG
(US8957075, Table 1 Compound 27)
Show SMILES O=C(C(NS(=O)(=O)c1ccc2NC(=O)CCc2c1)c1ccccc1)N(Cc1ccco1)Cc1cccs1
Show InChI InChI=1S/C27H25N3O5S2/c31-25-13-10-20-16-23(11-12-24(20)28-25)37(33,34)29-26(19-6-2-1-3-7-19)27(32)30(17-21-8-4-14-35-21)18-22-9-5-15-36-22/h1-9,11-12,14-16,26,29H,10,13,17-18H2,(H,28,31)
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n/an/an/a 4.00E+3n/an/an/an/an/a



President and Fellows of Harvard College

US Patent


Assay Description
384-well plates (Costar #3654) were filled using a liquid handling robot with 20 uL of a mixture of 50 nM of a fluorescein-linked UDP-GlcNAc analog (...


US Patent US8957075 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B82
More data for this
Ligand-Target Pair
O-GlcNAc Transferase (OGT)


(Homo sapiens (Human))
BDBM147124
PNG
(US8957075, Table 1 Compound 19 | US8957075, Table ...)
Show SMILES CCOc1ccccc1N(C)S(=O)(=O)c1ccc2[nH]c(=O)ccc2c1
Show InChI InChI=1S/C18H18N2O4S/c1-3-24-17-7-5-4-6-16(17)20(2)25(22,23)14-9-10-15-13(12-14)8-11-18(21)19-15/h4-12H,3H2,1-2H3,(H,19,21)
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n/an/an/a 4.10E+3n/an/an/an/an/a



President and Fellows of Harvard College

US Patent


Assay Description
384-well plates (Costar #3654) were filled using a liquid handling robot with 20 uL of a mixture of 50 nM of a fluorescein-linked UDP-GlcNAc analog (...


US Patent US8957075 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B82
More data for this
Ligand-Target Pair
O-GlcNAc Transferase (OGT)


(Homo sapiens (Human))
BDBM51358
PNG
(2-keto-N-[2-keto-1-phenyl-2-[4-(2-pyridyl)piperazi...)
Show SMILES O=C(C(NS(=O)(=O)c1ccc2NC(=O)CCc2c1)c1ccccc1)N1CCN(CC1)c1ccccn1
Show InChI InChI=1S/C26H27N5O4S/c32-24-12-9-20-18-21(10-11-22(20)28-24)36(34,35)29-25(19-6-2-1-3-7-19)26(33)31-16-14-30(15-17-31)23-8-4-5-13-27-23/h1-8,10-11,13,18,25,29H,9,12,14-17H2,(H,28,32)
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n/an/an/a 4.20E+3n/an/an/an/an/a



President and Fellows of Harvard College

US Patent


Assay Description
384-well plates (Costar #3654) were filled using a liquid handling robot with 20 uL of a mixture of 50 nM of a fluorescein-linked UDP-GlcNAc analog (...


US Patent US8957075 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B82
More data for this
Ligand-Target Pair
O-GlcNAc Transferase (OGT)


(Homo sapiens (Human))
BDBM147123
PNG
(US8957075, Table 1 Compound 18)
Show SMILES CCOc1ccccc1NS(=O)(=O)c1ccc2[nH]c(=O)ccc2c1
Show InChI InChI=1S/C17H16N2O4S/c1-2-23-16-6-4-3-5-15(16)19-24(21,22)13-8-9-14-12(11-13)7-10-17(20)18-14/h3-11,19H,2H2,1H3,(H,18,20)
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n/an/an/a 4.70E+3n/an/an/an/an/a



President and Fellows of Harvard College

US Patent


Assay Description
384-well plates (Costar #3654) were filled using a liquid handling robot with 20 uL of a mixture of 50 nM of a fluorescein-linked UDP-GlcNAc analog (...


US Patent US8957075 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B82
More data for this
Ligand-Target Pair
O-GlcNAc Transferase (OGT)


(Homo sapiens (Human))
BDBM147118
PNG
(US8957075, Table 1 Compound 13)
Show SMILES Cc1cc(C)c(NC(=O)C(NS(=O)(=O)c2ccc3NC(=O)CCc3c2)c2ccccc2)c(C)c1
Show InChI InChI=1S/C26H27N3O4S/c1-16-13-17(2)24(18(3)14-16)28-26(31)25(19-7-5-4-6-8-19)29-34(32,33)21-10-11-22-20(15-21)9-12-23(30)27-22/h4-8,10-11,13-15,25,29H,9,12H2,1-3H3,(H,27,30)(H,28,31)
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n/an/an/a 5.60E+3n/an/an/an/an/a



President and Fellows of Harvard College

US Patent


Assay Description
384-well plates (Costar #3654) were filled using a liquid handling robot with 20 uL of a mixture of 50 nM of a fluorescein-linked UDP-GlcNAc analog (...


US Patent US8957075 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B82
More data for this
Ligand-Target Pair
O-GlcNAc Transferase (OGT)


(Homo sapiens (Human))
BDBM147119
PNG
(US8957075, Table 1 Compound 14 | US8957075, Table ...)
Show SMILES CC(C)N(Cc1ccccc1)C(=O)C(NS(=O)(=O)c1ccc2NC(=O)CCc2c1)c1ccccc1
Show InChI InChI=1S/C27H29N3O4S/c1-19(2)30(18-20-9-5-3-6-10-20)27(32)26(21-11-7-4-8-12-21)29-35(33,34)23-14-15-24-22(17-23)13-16-25(31)28-24/h3-12,14-15,17,19,26,29H,13,16,18H2,1-2H3,(H,28,31)
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n/an/an/a 5.70E+3n/an/an/an/an/a



President and Fellows of Harvard College

US Patent


Assay Description
384-well plates (Costar #3654) were filled using a liquid handling robot with 20 uL of a mixture of 50 nM of a fluorescein-linked UDP-GlcNAc analog (...


US Patent US8957075 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B82
More data for this
Ligand-Target Pair
O-GlcNAc Transferase (OGT)


(Homo sapiens (Human))
BDBM147108
PNG
(US8957075, Table 1 Compound 2)
Show SMILES COc1cccc(c1)N1CCN(CC1)C(=O)C(NS(=O)(=O)c1ccc2NC(=O)CCc2c1)c1ccccc1
Show InChI InChI=1S/C28H30N4O5S/c1-37-23-9-5-8-22(19-23)31-14-16-32(17-15-31)28(34)27(20-6-3-2-4-7-20)30-38(35,36)24-11-12-25-21(18-24)10-13-26(33)29-25/h2-9,11-12,18-19,27,30H,10,13-17H2,1H3,(H,29,33)
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n/an/an/a 6.30E+3n/an/an/an/an/a



President and Fellows of Harvard College

US Patent


Assay Description
384-well plates (Costar #3654) were filled using a liquid handling robot with 20 uL of a mixture of 50 nM of a fluorescein-linked UDP-GlcNAc analog (...


US Patent US8957075 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B82
More data for this
Ligand-Target Pair
O-GlcNAc Transferase (OGT)


(Homo sapiens (Human))
BDBM147109
PNG
(US8957075, Table 1 Compound 3)
Show SMILES Clc1ccc(CNC(=O)C(NS(=O)(=O)c2ccc3NC(=O)CCc3c2)c2ccccc2)cc1
Show InChI InChI=1S/C24H22ClN3O4S/c25-19-9-6-16(7-10-19)15-26-24(30)23(17-4-2-1-3-5-17)28-33(31,32)20-11-12-21-18(14-20)8-13-22(29)27-21/h1-7,9-12,14,23,28H,8,13,15H2,(H,26,30)(H,27,29)
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n/an/an/a 6.60E+3n/an/an/an/an/a



President and Fellows of Harvard College

US Patent


Assay Description
384-well plates (Costar #3654) were filled using a liquid handling robot with 20 uL of a mixture of 50 nM of a fluorescein-linked UDP-GlcNAc analog (...


US Patent US8957075 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B82
More data for this
Ligand-Target Pair
O-GlcNAc Transferase (OGT)


(Homo sapiens (Human))
BDBM147119
PNG
(US8957075, Table 1 Compound 14 | US8957075, Table ...)
Show SMILES CC(C)N(Cc1ccccc1)C(=O)C(NS(=O)(=O)c1ccc2NC(=O)CCc2c1)c1ccccc1
Show InChI InChI=1S/C27H29N3O4S/c1-19(2)30(18-20-9-5-3-6-10-20)27(32)26(21-11-7-4-8-12-21)29-35(33,34)23-14-15-24-22(17-23)13-16-25(31)28-24/h3-12,14-15,17,19,26,29H,13,16,18H2,1-2H3,(H,28,31)
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n/an/an/a 7.00E+3n/an/an/an/an/a



President and Fellows of Harvard College

US Patent


Assay Description
384-well plates (Costar #3654) were filled using a liquid handling robot with 20 uL of a mixture of 50 nM of a fluorescein-linked UDP-GlcNAc analog (...


US Patent US8957075 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B82
More data for this
Ligand-Target Pair
O-GlcNAc Transferase (OGT)


(Homo sapiens (Human))
BDBM147125
PNG
(US8957075, Table 1 Compound 20)
Show SMILES COc1ccc(NS(=O)(=O)c2ccc3[nH]c(=O)ccc3c2)cc1OC
Show InChI InChI=1S/C17H16N2O5S/c1-23-15-7-4-12(10-16(15)24-2)19-25(21,22)13-5-6-14-11(9-13)3-8-17(20)18-14/h3-10,19H,1-2H3,(H,18,20)
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n/an/an/a 7.20E+3n/an/an/an/an/a



President and Fellows of Harvard College

US Patent


Assay Description
384-well plates (Costar #3654) were filled using a liquid handling robot with 20 uL of a mixture of 50 nM of a fluorescein-linked UDP-GlcNAc analog (...


US Patent US8957075 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B82
More data for this
Ligand-Target Pair
O-GlcNAc Transferase (OGT)


(Homo sapiens (Human))
BDBM147107
PNG
(US8957075, Table 1 Compound 1)
Show SMILES CN(C(=O)C(NS(=O)(=O)c1ccc2NC(=O)CCc2c1)c1ccccc1)c1cccc(C)c1
Show InChI InChI=1S/C25H25N3O4S/c1-17-7-6-10-20(15-17)28(2)25(30)24(18-8-4-3-5-9-18)27-33(31,32)21-12-13-22-19(16-21)11-14-23(29)26-22/h3-10,12-13,15-16,24,27H,11,14H2,1-2H3,(H,26,29)
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n/an/an/a 7.40E+3n/an/an/an/an/a



President and Fellows of Harvard College

US Patent


Assay Description
384-well plates (Costar #3654) were filled using a liquid handling robot with 20 uL of a mixture of 50 nM of a fluorescein-linked UDP-GlcNAc analog (...


US Patent US8957075 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B82
More data for this
Ligand-Target Pair
O-GlcNAc Transferase (OGT)


(Homo sapiens (Human))
BDBM147127
PNG
(US8957075, Table 1 Compound 22)
Show SMILES Cc1ccc(cc1)N1CCN(CC1)C(=O)C(NS(=O)(=O)c1ccc2NC(=O)CCc2c1)c1ccccc1
Show InChI InChI=1S/C28H30N4O4S/c1-20-7-10-23(11-8-20)31-15-17-32(18-16-31)28(34)27(21-5-3-2-4-6-21)30-37(35,36)24-12-13-25-22(19-24)9-14-26(33)29-25/h2-8,10-13,19,27,30H,9,14-18H2,1H3,(H,29,33)
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n/an/an/a 9.00E+3n/an/an/an/an/a



President and Fellows of Harvard College

US Patent


Assay Description
384-well plates (Costar #3654) were filled using a liquid handling robot with 20 uL of a mixture of 50 nM of a fluorescein-linked UDP-GlcNAc analog (...


US Patent US8957075 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B82
More data for this
Ligand-Target Pair
O-GlcNAc Transferase (OGT)


(Homo sapiens (Human))
BDBM147115
PNG
(US8957075, Table 1 Compound 10)
Show SMILES O=C(C(NS(=O)(=O)c1ccc2NC(=O)CCc2c1)c1ccccc1)N1CCN(CC1)C(=O)c1ccco1
Show InChI InChI=1S/C26H26N4O6S/c31-23-11-8-19-17-20(9-10-21(19)27-23)37(34,35)28-24(18-5-2-1-3-6-18)26(33)30-14-12-29(13-15-30)25(32)22-7-4-16-36-22/h1-7,9-10,16-17,24,28H,8,11-15H2,(H,27,31)
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n/an/an/a 1.10E+4n/an/an/an/an/a



President and Fellows of Harvard College

US Patent


Assay Description
384-well plates (Costar #3654) were filled using a liquid handling robot with 20 uL of a mixture of 50 nM of a fluorescein-linked UDP-GlcNAc analog (...


US Patent US8957075 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B82
More data for this
Ligand-Target Pair
O-GlcNAc Transferase (OGT)


(Homo sapiens (Human))
BDBM147122
PNG
(US8957075, Table 1 Compound 17)
Show SMILES CN(Cc1ccco1)C(=O)C(Cc1ccccc1)NS(=O)(=O)c1ccc2NC(=O)CCc2c1
Show InChI InChI=1S/C24H25N3O5S/c1-27(16-19-8-5-13-32-19)24(29)22(14-17-6-3-2-4-7-17)26-33(30,31)20-10-11-21-18(15-20)9-12-23(28)25-21/h2-8,10-11,13,15,22,26H,9,12,14,16H2,1H3,(H,25,28)
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n/an/an/a 1.30E+4n/an/an/an/an/a



President and Fellows of Harvard College

US Patent


Assay Description
384-well plates (Costar #3654) were filled using a liquid handling robot with 20 uL of a mixture of 50 nM of a fluorescein-linked UDP-GlcNAc analog (...


US Patent US8957075 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B82
More data for this
Ligand-Target Pair
O-GlcNAc Transferase (OGT)


(Homo sapiens (Human))
BDBM147121
PNG
(US8957075, Table 1 Compound 16)
Show SMILES OC(=O)CC(NS(=O)(=O)c1ccc2NC(=O)CCc2c1)c1cccc(Cl)c1
Show InChI InChI=1S/C18H17ClN2O5S/c19-13-3-1-2-11(8-13)16(10-18(23)24)21-27(25,26)14-5-6-15-12(9-14)4-7-17(22)20-15/h1-3,5-6,8-9,16,21H,4,7,10H2,(H,20,22)(H,23,24)
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n/an/an/a 1.50E+4n/an/an/an/an/a



President and Fellows of Harvard College

US Patent


Assay Description
384-well plates (Costar #3654) were filled using a liquid handling robot with 20 uL of a mixture of 50 nM of a fluorescein-linked UDP-GlcNAc analog (...


US Patent US8957075 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B82
More data for this
Ligand-Target Pair
O-GlcNAc Transferase (OGT)


(Homo sapiens (Human))
BDBM147113
PNG
(US8957075, Table 1 Compound 8)
Show SMILES O=C(C(NS(=O)(=O)c1ccc2NC(=O)CCc2c1)c1ccccc1)N1CCN(CC1)C1CCCCC1
Show InChI InChI=1S/C27H34N4O4S/c32-25-14-11-21-19-23(12-13-24(21)28-25)36(34,35)29-26(20-7-3-1-4-8-20)27(33)31-17-15-30(16-18-31)22-9-5-2-6-10-22/h1,3-4,7-8,12-13,19,22,26,29H,2,5-6,9-11,14-18H2,(H,28,32)
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n/an/an/a 2.00E+4n/an/an/an/an/a



President and Fellows of Harvard College

US Patent


Assay Description
384-well plates (Costar #3654) were filled using a liquid handling robot with 20 uL of a mixture of 50 nM of a fluorescein-linked UDP-GlcNAc analog (...


US Patent US8957075 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B82
More data for this
Ligand-Target Pair
O-GlcNAc Transferase (OGT)


(Homo sapiens (Human))
BDBM147120
PNG
(US8957075, Table 1 Compound 15)
Show SMILES CCN(CC)C(=O)C(NS(=O)(=O)c1ccc2NC(=O)CCc2c1)c1ccccc1
Show InChI InChI=1S/C21H25N3O4S/c1-3-24(4-2)21(26)20(15-8-6-5-7-9-15)23-29(27,28)17-11-12-18-16(14-17)10-13-19(25)22-18/h5-9,11-12,14,20,23H,3-4,10,13H2,1-2H3,(H,22,25)
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n/an/an/a 2.10E+4n/an/an/an/an/a



President and Fellows of Harvard College

US Patent


Assay Description
384-well plates (Costar #3654) were filled using a liquid handling robot with 20 uL of a mixture of 50 nM of a fluorescein-linked UDP-GlcNAc analog (...


US Patent US8957075 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B82
More data for this
Ligand-Target Pair
O-GlcNAc Transferase (OGT)


(Homo sapiens (Human))
BDBM147111
PNG
(US8957075, Table 1 Compound 5)
Show SMILES Cc1cccc(C)c1NC(=O)C(NS(=O)(=O)c1ccc2NC(=O)CCc2c1)c1ccccc1
Show InChI InChI=1S/C25H25N3O4S/c1-16-7-6-8-17(2)23(16)27-25(30)24(18-9-4-3-5-10-18)28-33(31,32)20-12-13-21-19(15-20)11-14-22(29)26-21/h3-10,12-13,15,24,28H,11,14H2,1-2H3,(H,26,29)(H,27,30)
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n/an/an/a 3.70E+4n/an/an/an/an/a



President and Fellows of Harvard College

US Patent


Assay Description
384-well plates (Costar #3654) were filled using a liquid handling robot with 20 uL of a mixture of 50 nM of a fluorescein-linked UDP-GlcNAc analog (...


US Patent US8957075 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B82
More data for this
Ligand-Target Pair
O-GlcNAc Transferase (OGT)


(Homo sapiens (Human))
BDBM147130
PNG
(US8957075, Table 1 Compound 25)
Show SMILES COc1cc2CCN(C(C)c2cc1OC)S(=O)(=O)c1ccc2[nH]c(=O)ccc2c1
Show InChI InChI=1S/C21H22N2O5S/c1-13-17-12-20(28-3)19(27-2)11-14(17)8-9-23(13)29(25,26)16-5-6-18-15(10-16)4-7-21(24)22-18/h4-7,10-13H,8-9H2,1-3H3,(H,22,24)
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n/an/an/a 5.00E+4n/an/an/an/an/a



President and Fellows of Harvard College

US Patent


Assay Description
384-well plates (Costar #3654) were filled using a liquid handling robot with 20 uL of a mixture of 50 nM of a fluorescein-linked UDP-GlcNAc analog (...


US Patent US8957075 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B82
More data for this
Ligand-Target Pair
O-GlcNAc Transferase (OGT)


(Homo sapiens (Human))
BDBM147124
PNG
(US8957075, Table 1 Compound 19 | US8957075, Table ...)
Show SMILES CCOc1ccccc1N(C)S(=O)(=O)c1ccc2[nH]c(=O)ccc2c1
Show InChI InChI=1S/C18H18N2O4S/c1-3-24-17-7-5-4-6-16(17)20(2)25(22,23)14-9-10-15-13(12-14)8-11-18(21)19-15/h4-12H,3H2,1-2H3,(H,19,21)
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n/an/an/a 5.00E+4n/an/an/an/an/a



President and Fellows of Harvard College

US Patent


Assay Description
384-well plates (Costar #3654) were filled using a liquid handling robot with 20 uL of a mixture of 50 nM of a fluorescein-linked UDP-GlcNAc analog (...


US Patent US8957075 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B82
More data for this
Ligand-Target Pair
O-GlcNAc Transferase (OGT)


(Homo sapiens (Human))
BDBM147114
PNG
(US8957075, Table 1 Compound 9)
Show SMILES Cc1ccc(NC(=O)C(NS(=O)(=O)c2ccc3NC(=O)CCc3c2)c2ccccc2)c(Br)c1
Show InChI InChI=1S/C24H22BrN3O4S/c1-15-7-10-21(19(25)13-15)27-24(30)23(16-5-3-2-4-6-16)28-33(31,32)18-9-11-20-17(14-18)8-12-22(29)26-20/h2-7,9-11,13-14,23,28H,8,12H2,1H3,(H,26,29)(H,27,30)
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n/an/an/a 5.20E+4n/an/an/an/an/a



President and Fellows of Harvard College

US Patent


Assay Description
384-well plates (Costar #3654) were filled using a liquid handling robot with 20 uL of a mixture of 50 nM of a fluorescein-linked UDP-GlcNAc analog (...


US Patent US8957075 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B82
More data for this
Ligand-Target Pair
O-GlcNAc Transferase (OGT)


(Homo sapiens (Human))
BDBM147128
PNG
(US8957075, Table 1 Compound 23)
Show SMILES CN(CC(=O)Nc1nc2ccc(Cl)cc2s1)S(=O)(=O)c1ccc2[nH]c(=O)ccc2c1
Show InChI InChI=1S/C19H15ClN4O4S2/c1-24(10-18(26)23-19-22-15-5-3-12(20)9-16(15)29-19)30(27,28)13-4-6-14-11(8-13)2-7-17(25)21-14/h2-9H,10H2,1H3,(H,21,25)(H,22,23,26)
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n/an/an/a 6.00E+4n/an/an/an/an/a



President and Fellows of Harvard College

US Patent


Assay Description
384-well plates (Costar #3654) were filled using a liquid handling robot with 20 uL of a mixture of 50 nM of a fluorescein-linked UDP-GlcNAc analog (...


US Patent US8957075 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B82
More data for this
Ligand-Target Pair
O-GlcNAc Transferase (OGT)


(Homo sapiens (Human))
BDBM147112
PNG
(US8957075, Table 1 Compound 7)
Show SMILES CCc1cccc(C)c1NC(=O)C(NS(=O)(=O)c1ccc2NC(=O)CCc2c1)c1ccccc1
Show InChI InChI=1S/C26H27N3O4S/c1-3-18-11-7-8-17(2)24(18)28-26(31)25(19-9-5-4-6-10-19)29-34(32,33)21-13-14-22-20(16-21)12-15-23(30)27-22/h4-11,13-14,16,25,29H,3,12,15H2,1-2H3,(H,27,30)(H,28,31)
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n/an/an/a 9.70E+4n/an/an/an/an/a



President and Fellows of Harvard College

US Patent


Assay Description
384-well plates (Costar #3654) were filled using a liquid handling robot with 20 uL of a mixture of 50 nM of a fluorescein-linked UDP-GlcNAc analog (...


US Patent US8957075 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B82
More data for this
Ligand-Target Pair
O-GlcNAc Transferase (OGT)


(Homo sapiens (Human))
BDBM147129
PNG
(US8957075, Table 1 Compound 24)
Show SMILES O=C(NCc1ccccc1)C(NS(=O)(=O)c1ccc2NC(=O)CCc2c1)c1ccccc1
Show InChI InChI=1S/C24H23N3O4S/c28-22-14-11-19-15-20(12-13-21(19)26-22)32(30,31)27-23(18-9-5-2-6-10-18)24(29)25-16-17-7-3-1-4-8-17/h1-10,12-13,15,23,27H,11,14,16H2,(H,25,29)(H,26,28)
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n/an/an/a 1.25E+5n/an/an/an/an/a



President and Fellows of Harvard College

US Patent


Assay Description
384-well plates (Costar #3654) were filled using a liquid handling robot with 20 uL of a mixture of 50 nM of a fluorescein-linked UDP-GlcNAc analog (...


US Patent US8957075 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B82
More data for this
Ligand-Target Pair
O-GlcNAc Transferase (OGT)


(Homo sapiens (Human))
BDBM50200114
PNG
(CHEMBL3920498)
Show SMILES CC(=O)Nc1ccc(cc1)-n1cc(nn1)-c1ccc2ccccc2c1
Show InChI InChI=1S/C20H16N4O/c1-14(25)21-18-8-10-19(11-9-18)24-13-20(22-23-24)17-7-6-15-4-2-3-5-16(15)12-17/h2-13H,1H3,(H,21,25)
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2.86E+4n/an/an/an/an/an/an/an/a



University of Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Noncompetitive inhibition of OGT (unknown origin) using variable UDP-GlcNAc levels and fixed CKII peptide level by UDP-Glo glycosyltransferase assay


J Med Chem 60: 263-272 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01237
BindingDB Entry DOI: 10.7270/Q20G3N47
More data for this
Ligand-Target Pair
O-GlcNAc Transferase (OGT)


(Homo sapiens (Human))
BDBM50200114
PNG
(CHEMBL3920498)
Show SMILES CC(=O)Nc1ccc(cc1)-n1cc(nn1)-c1ccc2ccccc2c1
Show InChI InChI=1S/C20H16N4O/c1-14(25)21-18-8-10-19(11-9-18)24-13-20(22-23-24)17-7-6-15-4-2-3-5-16(15)12-17/h2-13H,1H3,(H,21,25)
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5.98E+4n/an/an/an/an/an/an/an/a



University of Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Noncompetitive inhibition of OGT (unknown origin) using fixed UDP-GlcNAc levels and variable CKII peptide level by UDP-Glo glycosyltransferase assay


J Med Chem 60: 263-272 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01237
BindingDB Entry DOI: 10.7270/Q20G3N47
More data for this
Ligand-Target Pair
O-GlcNAc Transferase (OGT)


(Homo sapiens (Human))
BDBM50200111
PNG
(CHEMBL3981566)
Show SMILES CC(=O)Nc1ccc(cc1)-n1cc(nn1)-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C22H18N4O/c1-16(27)23-20-11-13-21(14-12-20)26-15-22(24-25-26)19-9-7-18(8-10-19)17-5-3-2-4-6-17/h2-15H,1H3,(H,23,27)
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9.20E+4n/an/an/an/an/an/an/an/a



University of Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Noncompetitive inhibition of OGT (unknown origin) using variable UDP-GlcNAc levels and fixed CKII peptide level by UDP-Glo glycosyltransferase assay


J Med Chem 60: 263-272 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01237
BindingDB Entry DOI: 10.7270/Q20G3N47
More data for this
Ligand-Target Pair
O-GlcNAc Transferase (OGT)


(Homo sapiens (Human))
BDBM50200111
PNG
(CHEMBL3981566)
Show SMILES CC(=O)Nc1ccc(cc1)-n1cc(nn1)-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C22H18N4O/c1-16(27)23-20-11-13-21(14-12-20)26-15-22(24-25-26)19-9-7-18(8-10-19)17-5-3-2-4-6-17/h2-15H,1H3,(H,23,27)
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3.10E+5n/an/an/an/an/an/an/an/a



University of Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Noncompetitive inhibition of OGT (unknown origin) using fixed UDP-GlcNAc levels and variable CKII peptide level by UDP-Glo glycosyltransferase assay


J Med Chem 60: 263-272 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01237
BindingDB Entry DOI: 10.7270/Q20G3N47
More data for this
Ligand-Target Pair
O-GlcNAc Transferase (OGT)


(Homo sapiens (Human))
BDBM50200116
PNG
(CHEMBL3933877)
Show SMILES OC(C#C)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C15H12O/c1-2-15(16,13-9-5-3-6-10-13)14-11-7-4-8-12-14/h1,3-12,16H
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n/an/a 1.96E+6n/an/an/an/an/an/a



University of Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of OGT (unknown origin) assessed as reduction in GlcNAc transfer to CKII peptide incubated for 60 mins by HPLC method


J Med Chem 60: 263-272 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01237
BindingDB Entry DOI: 10.7270/Q20G3N47
More data for this
Ligand-Target Pair
O-GlcNAc Transferase (OGT)


(Homo sapiens (Human))
BDBM50027776
PNG
(4-Ethynyl Biphenyl | 4-Ethynyl-Biphenyl | CHEMBL37...)
Show SMILES C#Cc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C14H10/c1-2-12-8-10-14(11-9-12)13-6-4-3-5-7-13/h1,3-11H
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n/an/a>1.00E+6n/an/an/an/an/an/a



University of Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of OGT (unknown origin) assessed as reduction in GlcNAc transfer to CKII peptide incubated for 60 mins by HPLC method


J Med Chem 60: 263-272 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01237
BindingDB Entry DOI: 10.7270/Q20G3N47
More data for this
Ligand-Target Pair
O-GlcNAc Transferase (OGT)


(Homo sapiens (Human))
BDBM50200117
PNG
(CHEMBL3969655)
Show SMILES ICC(=O)Nc1ccc(cc1)N=[N+]=[N-]
Show InChI InChI=1S/C8H7IN4O/c9-5-8(14)11-6-1-3-7(4-2-6)12-13-10/h1-4H,5H2,(H,11,14)
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n/an/a 8.65E+5n/an/an/an/an/an/a



University of Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of OGT (unknown origin) assessed as reduction in GlcNAc transfer to CKII peptide incubated for 60 mins by HPLC method


J Med Chem 60: 263-272 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01237
BindingDB Entry DOI: 10.7270/Q20G3N47
More data for this
Ligand-Target Pair
O-GlcNAc Transferase (OGT)


(Homo sapiens (Human))
BDBM50168000
PNG
(3H-Benzooxazol-2-one | CHEMBL280323 | benzo[d]oxaz...)
Show SMILES O=c1[nH]c2ccccc2o1
Show InChI InChI=1S/C7H5NO2/c9-7-8-5-3-1-2-4-6(5)10-7/h1-4H,(H,8,9)
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n/an/a 1.19E+4n/an/an/an/an/an/a



University of Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of OGT (unknown origin) assessed as reduction in GlcNAc transfer to CKII peptide incubated for 60 mins by HPLC method


J Med Chem 60: 263-272 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01237
BindingDB Entry DOI: 10.7270/Q20G3N47
More data for this
Ligand-Target Pair
O-GlcNAc Transferase (OGT)


(Homo sapiens (Human))
BDBM50200114
PNG
(CHEMBL3920498)
Show SMILES CC(=O)Nc1ccc(cc1)-n1cc(nn1)-c1ccc2ccccc2c1
Show InChI InChI=1S/C20H16N4O/c1-14(25)21-18-8-10-19(11-9-18)24-13-20(22-23-24)17-7-6-15-4-2-3-5-16(15)12-17/h2-13H,1H3,(H,21,25)
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n/an/a 6.67E+4n/an/an/an/an/an/a



University of Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of OGT (unknown origin) assessed as reduction in GlcNAc transfer to CKII peptide incubated for 60 mins by HPLC method


J Med Chem 60: 263-272 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01237
BindingDB Entry DOI: 10.7270/Q20G3N47
More data for this
Ligand-Target Pair
O-GlcNAc Transferase (OGT)


(Homo sapiens (Human))
BDBM50200118
PNG
(CHEMBL3924189)
Show SMILES CC(=O)Nc1ccc(cc1)-n1cc(nn1)C(O)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C23H20N4O2/c1-17(28)24-20-12-14-21(15-13-20)27-16-22(25-26-27)23(29,18-8-4-2-5-9-18)19-10-6-3-7-11-19/h2-16,29H,1H3,(H,24,28)
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n/an/a 1.00E+6n/an/an/an/an/an/a



University of Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of OGT (unknown origin) assessed as reduction in GlcNAc transfer to CKII peptide incubated for 60 mins by HPLC method


J Med Chem 60: 263-272 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01237
BindingDB Entry DOI: 10.7270/Q20G3N47
More data for this
Ligand-Target Pair
O-GlcNAc Transferase (OGT)


(Homo sapiens (Human))
BDBM50200119
PNG
(CHEMBL3896658)
Show SMILES ClCC(=O)Nc1ccc(cc1)-n1cc(nn1)-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C22H17ClN4O/c23-14-22(28)24-19-10-12-20(13-11-19)27-15-21(25-26-27)18-8-6-17(7-9-18)16-4-2-1-3-5-16/h1-13,15H,14H2,(H,24,28)
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n/an/a 9.12E+4n/an/an/an/an/an/a



University of Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of OGT (unknown origin) assessed as reduction in GlcNAc transfer to CKII peptide incubated for 60 mins by HPLC method


J Med Chem 60: 263-272 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01237
BindingDB Entry DOI: 10.7270/Q20G3N47
More data for this
Ligand-Target Pair
O-GlcNAc Transferase (OGT)


(Homo sapiens (Human))
BDBM50200111
PNG
(CHEMBL3981566)
Show SMILES CC(=O)Nc1ccc(cc1)-n1cc(nn1)-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C22H18N4O/c1-16(27)23-20-11-13-21(14-12-20)26-15-22(24-25-26)19-9-7-18(8-10-19)17-5-3-2-4-6-17/h2-15H,1H3,(H,23,27)
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n/an/a 1.39E+5n/an/an/an/an/an/a



University of Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of OGT (unknown origin) assessed as reduction in GlcNAc transfer to CKII peptide incubated for 60 mins by HPLC method


J Med Chem 60: 263-272 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01237
BindingDB Entry DOI: 10.7270/Q20G3N47
More data for this
Ligand-Target Pair
O-GlcNAc Transferase (OGT)


(Homo sapiens (Human))
BDBM50200113
PNG
(CHEMBL3949890)
Show SMILES ClCC(=O)Nc1ccc(cc1)N=[N+]=[N-]
Show InChI InChI=1S/C8H7ClN4O/c9-5-8(14)11-6-1-3-7(4-2-6)12-13-10/h1-4H,5H2,(H,11,14)
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n/an/a 3.97E+6n/an/an/an/an/an/a



University of Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of OGT (unknown origin) assessed as reduction in GlcNAc transfer to CKII peptide incubated for 60 mins by HPLC method


J Med Chem 60: 263-272 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01237
BindingDB Entry DOI: 10.7270/Q20G3N47
More data for this
Ligand-Target Pair
O-GlcNAc Transferase (OGT)


(Homo sapiens (Human))
BDBM50200112
PNG
(CHEMBL3895218)
Show SMILES OC(c1cn(nn1)-c1ccc(NC(=O)CCl)cc1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C23H19ClN4O2/c24-15-22(29)25-19-11-13-20(14-12-19)28-16-21(26-27-28)23(30,17-7-3-1-4-8-17)18-9-5-2-6-10-18/h1-14,16,30H,15H2,(H,25,29)
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n/an/a 8.93E+4n/an/an/an/an/an/a



University of Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of OGT (unknown origin) assessed as reduction in GlcNAc transfer to CKII peptide incubated for 60 mins by HPLC method


J Med Chem 60: 263-272 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01237
BindingDB Entry DOI: 10.7270/Q20G3N47
More data for this
Ligand-Target Pair
O-GlcNAc Transferase (OGT)


(Homo sapiens (Human))
BDBM50200110
PNG
(CHEMBL3890166)
Show SMILES ClCC(=O)Nc1ccc(cc1)-n1cc(nn1)-c1ccc2ccccc2c1
Show InChI InChI=1S/C20H15ClN4O/c21-12-20(26)22-17-7-9-18(10-8-17)25-13-19(23-24-25)16-6-5-14-3-1-2-4-15(14)11-16/h1-11,13H,12H2,(H,22,26)
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n/an/a 7.17E+4n/an/an/an/an/an/a



University of Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of OGT (unknown origin) assessed as reduction in GlcNAc transfer to CKII peptide incubated for 60 mins by HPLC method


J Med Chem 60: 263-272 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01237
BindingDB Entry DOI: 10.7270/Q20G3N47
More data for this
Ligand-Target Pair
O-GlcNAc Transferase (OGT)


(Homo sapiens (Human))
BDBM50118239
PNG
(CHEMBL130266 | UDP | Uridine diphosphate | uridine...)
Show SMILES O[C@@H]1[C@@H](COP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O
Show InChI InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
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n/an/a 1.80E+3n/an/an/an/an/an/a



University of British Columbia

Curated by ChEMBL


Assay Description
Inhibition of human OGT


Bioorg Med Chem Lett 21: 1199-201 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.090
BindingDB Entry DOI: 10.7270/Q2028RT6
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
O-GlcNAc Transferase (OGT)


(Homo sapiens (Human))
BDBM50027783
PNG
(2-Ethynyl Naphtalene | CHEMBL1743361)
Show SMILES C#Cc1ccc2ccccc2c1
Show InChI InChI=1S/C12H8/c1-2-10-7-8-11-5-3-4-6-12(11)9-10/h1,3-9H
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n/an/a>4.00E+6n/an/an/an/an/an/a



University of Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of OGT (unknown origin) assessed as reduction in GlcNAc transfer to CKII peptide incubated for 60 mins by HPLC method


J Med Chem 60: 263-272 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01237
BindingDB Entry DOI: 10.7270/Q20G3N47
More data for this
Ligand-Target Pair
O-GlcNAc Transferase (OGT)


(Homo sapiens (Human))
BDBM50200115
PNG
(CHEMBL3892504)
Show SMILES CC(=O)Nc1ccc(cc1)N=[N+]=[N-]
Show InChI InChI=1S/C8H8N4O/c1-6(13)10-7-2-4-8(5-3-7)11-12-9/h2-5H,1H3,(H,10,13)
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n/an/a>4.00E+6n/an/an/an/an/an/a



University of Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of OGT (unknown origin) assessed as reduction in GlcNAc transfer to CKII peptide incubated for 60 mins by HPLC method


J Med Chem 60: 263-272 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01237
BindingDB Entry DOI: 10.7270/Q20G3N47
More data for this
Ligand-Target Pair