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Compile Data Set for Download or QSAR

Found 4097 hits Enz. Inhib. hit(s) with Target = 'Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50192880
PNG
(CHEMBL3984425)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3cnn(C)c3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C30H24N8O2/c1-19(34-29(39)26-27(31)35-37-15-7-14-32-28(26)37)24-16-22-9-6-8-21(13-12-20-17-33-36(2)18-20)25(22)30(40)38(24)23-10-4-3-5-11-23/h3-11,14-19H,1-2H3,(H2,31,35)(H,34,39)/t19-/m0/s1
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n/an/an/a 0.290n/an/an/an/an/a



Infinity Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human recombinant full length N-terminal His-tagged PI3Kgamma expressed in Sf9 insect cells by equilibrium fluorescence titration...


ACS Med Chem Lett 7: 862-7 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00238
BindingDB Entry DOI: 10.7270/Q2N018HX
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM25084
PNG
(3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]ph...)
Show SMILES Nc1nc(N)c2nc(-c3cccc(O)c3)c(nc2n1)-c1cccc(O)c1
Show InChI InChI=1S/C18H14N6O2/c19-16-15-17(24-18(20)23-16)22-14(10-4-2-6-12(26)8-10)13(21-15)9-3-1-5-11(25)7-9/h1-8,25-26H,(H4,19,20,22,23,24)
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n/an/an/a 5.30n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for PIK3CG kinase domain


Nat Biotechnol 29: 1046-51 (2011)


Article DOI: 10.1038/nbt.1990
BindingDB Entry DOI: 10.7270/Q25D8S70
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM25045
PNG
(3-(4-morpholin-4-ylpyrido[2,3]furo[2,4-b]pyrimidin...)
Show SMILES Oc1cccc(c1)-c1nc(N2CCOCC2)c2oc3ncccc3c2n1
Show InChI InChI=1S/C19H16N4O3/c24-13-4-1-3-12(11-13)17-21-15-14-5-2-6-20-19(14)26-16(15)18(22-17)23-7-9-25-10-8-23/h1-6,11,24H,7-10H2
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n/an/an/a 16n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for PIK3CG kinase domain


Nat Biotechnol 29: 1046-51 (2011)


Article DOI: 10.1038/nbt.1990
BindingDB Entry DOI: 10.7270/Q25D8S70
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM36409
PNG
(2-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin...)
Show SMILES CC(C)n1nc(-c2cc3cc(O)ccc3[nH]2)c2c(N)ncnc12
Show InChI InChI=1S/C16H16N6O/c1-8(2)22-16-13(15(17)18-7-19-16)14(21-22)12-6-9-5-10(23)3-4-11(9)20-12/h3-8,20,23H,1-2H3,(H2,17,18,19)
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n/an/an/a 42n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for PIK3CG kinase domain


Nat Biotechnol 29: 1046-51 (2011)


Article DOI: 10.1038/nbt.1990
BindingDB Entry DOI: 10.7270/Q25D8S70
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM25028
PNG
(4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpipera...)
Show SMILES CS(=O)(=O)N1CCN(Cc2cc3nc(nc(N4CCOCC4)c3s2)-c2cccc3[nH]ncc23)CC1
Show InChI InChI=1S/C23H27N7O3S2/c1-35(31,32)30-7-5-28(6-8-30)15-16-13-20-21(34-16)23(29-9-11-33-12-10-29)26-22(25-20)17-3-2-4-19-18(17)14-24-27-19/h2-4,13-14H,5-12,15H2,1H3,(H,24,27)
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n/an/an/a 48n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for PIK3CG kinase domain


Nat Biotechnol 29: 1046-51 (2011)


Article DOI: 10.1038/nbt.1990
BindingDB Entry DOI: 10.7270/Q25D8S70
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM15236
PNG
(3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chr...)
Show SMILES Oc1cc(O)c2c(c1)oc(-c1cc(O)c(O)c(O)c1)c(O)c2=O
Show InChI InChI=1S/C15H10O8/c16-6-3-7(17)11-10(4-6)23-15(14(22)13(11)21)5-1-8(18)12(20)9(19)2-5/h1-4,16-20,22H
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n/an/a 1.80E+3 170n/an/an/a7.220



MRC



Assay Description
Binding was detected as a change in the intrinsic tryptophan fluorescence of the PI3K upon the addition of inhibitor. The inhibitor was incubated wit...


Mol Cell 6: 909-19 (2000)


BindingDB Entry DOI: 10.7270/Q22F7KPC
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM12915
PNG
(2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one |...)
Show SMILES O=c1cc(oc2c(cccc12)-c1ccccc1)N1CCOCC1
Show InChI InChI=1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2
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n/an/a 1.40E+3 210n/an/an/a7.220



MRC



Assay Description
Binding was detected as a change in the intrinsic tryptophan fluorescence of the PI3K upon the addition of inhibitor. The inhibitor was incubated wit...


Mol Cell 6: 909-19 (2000)


BindingDB Entry DOI: 10.7270/Q22F7KPC
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM288377
PNG
(US10087187, Compound 68)
Show SMILES Cc1c(Nc2c(CO)nc3c(cc(nn23)N2CCOC(CO)C2)-c2c[nH]cn2)cccc1C(F)(F)F
Show InChI InChI=1S/C23H24F3N7O3/c1-13-16(23(24,25)26)3-2-4-17(13)29-22-19(11-35)30-21-15(18-8-27-12-28-18)7-20(31-33(21)22)32-5-6-36-14(9-32)10-34/h2-4,7-8,12,14,29,34-35H,5-6,9-11H2,1H3,(H,27,28)
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n/an/an/a 234n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM7460
PNG
(2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chrome...)
Show SMILES Oc1cc(O)c2c(c1)oc(-c1ccc(O)c(O)c1)c(O)c2=O
Show InChI InChI=1S/C15H10O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,16-19,21H
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n/an/a 3.80E+3 280n/an/an/a7.220



MRC



Assay Description
Binding was detected as a change in the intrinsic tryptophan fluorescence of the PI3K upon the addition of inhibitor. The inhibitor was incubated wit...


Mol Cell 6: 909-19 (2000)


BindingDB Entry DOI: 10.7270/Q22F7KPC
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a 9.00E+3 290n/an/an/a7.220



MRC



Assay Description
Binding was detected as a change in the intrinsic tryptophan fluorescence of the PI3K upon the addition of inhibitor. The inhibitor was incubated wit...


Mol Cell 6: 909-19 (2000)


BindingDB Entry DOI: 10.7270/Q22F7KPC
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM288376
PNG
(US10087187, Compound 67)
Show SMILES Cc1c(Cl)cccc1Nc1c(CO)nc2c(cc(nn12)N1CCOCC1)-c1c[nH]cn1
Show InChI InChI=1S/C21H22ClN7O2/c1-13-15(22)3-2-4-16(13)25-21-18(11-30)26-20-14(17-10-23-12-24-17)9-19(27-29(20)21)28-5-7-31-8-6-28/h2-4,9-10,12,25,30H,5-8,11H2,1H3,(H,23,24)
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n/an/an/a 324n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50308060
PNG
(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Show SMILES C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4C(=O)NCc4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C26H21N3O4/c1-25-26(32,12-30)10-18(33-25)28-16-8-4-2-6-13(16)20-21-15(11-27-24(21)31)19-14-7-3-5-9-17(14)29(25)23(19)22(20)28/h2-9,18,30,32H,10-12H2,1H3,(H,27,31)/t18-,25+,26+/m1/s1
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n/an/an/a 350n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for PIK3CG kinase domain


Nat Biotechnol 29: 1046-51 (2011)


Article DOI: 10.1038/nbt.1990
BindingDB Entry DOI: 10.7270/Q25D8S70
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50308060
PNG
(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Show SMILES C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4C(=O)NCc4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C26H21N3O4/c1-25-26(32,12-30)10-18(33-25)28-16-8-4-2-6-13(16)20-21-15(11-27-24(21)31)19-14-7-3-5-9-17(14)29(25)23(19)22(20)28/h2-9,18,30,32H,10-12H2,1H3,(H,27,31)/t18-,25+,26+/m1/s1
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n/an/an/a 350n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding affinity to PIK3CG


Blood 114: 2984-92 (2009)


Article DOI: 10.1182/blood-2009-05-222034
BindingDB Entry DOI: 10.7270/Q2PN95V2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50342916
PNG
(6-(benzo[d][1,3]dioxol-5-yl)-N-methyl-N-((2-methyl...)
Show SMILES CN(Cc1csc(C)n1)c1ncnc2ccc(cc12)-c1ccc2OCOc2c1
Show InChI InChI=1S/C21H18N4O2S/c1-13-24-16(10-28-13)9-25(2)21-17-7-14(3-5-18(17)22-11-23-21)15-4-6-19-20(8-15)27-12-26-19/h3-8,10-11H,9,12H2,1-2H3
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n/an/an/a 370n/an/an/an/an/a



National Human Genome Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to human PIK3CG


Bioorg Med Chem Lett 21: 3152-8 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.114
BindingDB Entry DOI: 10.7270/Q2J67H83
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50059657
PNG
(CHEMBL3393602)
Show SMILES O=C(O\N=C1\c2ccccc2-c2nc3ccccc3nc12)c1ccco1
Show InChI InChI=1S/C20H11N3O3/c24-20(16-10-5-11-25-16)26-23-18-13-7-2-1-6-12(13)17-19(18)22-15-9-4-3-8-14(15)21-17/h1-11H/b23-18-
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n/an/an/a 430n/an/an/an/an/a



Eberhard Karls Universit£t T£bingen

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma (unknown origin) by KINOMEScan assay


J Med Chem 58: 72-95 (2015)


Article DOI: 10.1021/jm501212r
BindingDB Entry DOI: 10.7270/Q2JH3NVZ
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50059656
PNG
(CHEMBL3393601)
Show SMILES O\N=C1\c2ccccc2-c2nc3ccccc3nc12
Show InChI InChI=1S/C15H9N3O/c19-18-14-10-6-2-1-5-9(10)13-15(14)17-12-8-4-3-7-11(12)16-13/h1-8,19H/b18-14-
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n/an/an/a 470n/an/an/an/an/a



Eberhard Karls Universit£t T£bingen

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma (unknown origin) by KINOMEScan assay


J Med Chem 58: 72-95 (2015)


Article DOI: 10.1021/jm501212r
BindingDB Entry DOI: 10.7270/Q2JH3NVZ
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM288335
PNG
(US10087187, Compound 25 | US10087187, Compound 27)
Show SMILES CC1CN(CCO1)c1cc(-c2c[nH]cn2)c2nc(CO)c(Cc3cccc(c3C)C(F)(F)F)n2n1
Show InChI InChI=1S/C24H25F3N6O2/c1-14-11-32(6-7-35-14)22-9-17(19-10-28-13-29-19)23-30-20(12-34)21(33(23)31-22)8-16-4-3-5-18(15(16)2)24(25,26)27/h3-5,9-10,13-14,34H,6-8,11-12H2,1-2H3,(H,28,29)
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n/an/an/a 479n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM288331
PNG
(US10087187, Compound 21)
Show SMILES Cc1c(Cc2c(CO)nc3c(cc(nn23)N2CCOCC2)-c2ccn[nH]2)cccc1C(F)(F)F
Show InChI InChI=1S/C23H23F3N6O2/c1-14-15(3-2-4-17(14)23(24,25)26)11-20-19(13-33)28-22-16(18-5-6-27-29-18)12-21(30-32(20)22)31-7-9-34-10-8-31/h2-6,12,33H,7-11,13H2,1H3,(H,27,29)
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n/an/an/a 617n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50200930
PNG
(CHEMBL3928423 | US10087187, Compound 66)
Show SMILES Cc1c(Nc2c(CO)nc3c(N)cc(nn23)N2CCOC(CO)C2)cccc1C(F)(F)F
Show InChI InChI=1S/C20H23F3N6O3/c1-11-13(20(21,22)23)3-2-4-15(11)25-19-16(10-31)26-18-14(24)7-17(27-29(18)19)28-5-6-32-12(8-28)9-30/h2-4,7,12,25,30-31H,5-6,8-10,24H2,1H3
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n/an/an/a 692n/an/an/an/an/a



Dart Neuroscience LLC

Curated by ChEMBL


Assay Description
Binding affinity to human PI3Kgamma (144 to 1102 residues) expressed in mammalian expression system by KINOMEscan assay


ACS Med Chem Lett 7: 1012-1013 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00406
BindingDB Entry DOI: 10.7270/Q2N29ZX9
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50200930
PNG
(CHEMBL3928423 | US10087187, Compound 66)
Show SMILES Cc1c(Nc2c(CO)nc3c(N)cc(nn23)N2CCOC(CO)C2)cccc1C(F)(F)F
Show InChI InChI=1S/C20H23F3N6O3/c1-11-13(20(21,22)23)3-2-4-15(11)25-19-16(10-31)26-18-14(24)7-17(27-29(18)19)28-5-6-32-12(8-28)9-30/h2-4,7,12,25,30-31H,5-6,8-10,24H2,1H3
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n/an/an/a 692n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM288400
PNG
(US10087187, Compound 101)
Show SMILES CCc1c(F)cccc1Cc1c(CNCCO)nc2c(N)cc(nn12)N1CCOCC1
Show InChI InChI=1S/C22H29FN6O2/c1-2-16-15(4-3-5-17(16)23)12-20-19(14-25-6-9-30)26-22-18(24)13-21(27-29(20)22)28-7-10-31-11-8-28/h3-5,13,25,30H,2,6-12,14,24H2,1H3
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n/an/an/a 724n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50200968
PNG
(CHEMBL3983623 | US10087187, Compound 46)
Show SMILES Cc1nc2c(cc(nn2c1Nc1cccc(c1CN1CC(O)C1)C(F)(F)F)N1CCOCC1)-c1cnc[nH]1
Show InChI InChI=1S/C25H27F3N8O2/c1-15-23(32-20-4-2-3-19(25(26,27)28)18(20)13-34-11-16(37)12-34)36-24(31-15)17(21-10-29-14-30-21)9-22(33-36)35-5-7-38-8-6-35/h2-4,9-10,14,16,32,37H,5-8,11-13H2,1H3,(H,29,30)
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n/an/an/a 741n/an/an/an/an/a



Dart Neuroscience LLC

Curated by ChEMBL


Assay Description
Binding affinity to human PI3Kgamma (144 to 1102 residues) expressed in mammalian expression system by KINOMEscan assay


ACS Med Chem Lett 7: 1012-1013 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00406
BindingDB Entry DOI: 10.7270/Q2N29ZX9
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50200968
PNG
(CHEMBL3983623 | US10087187, Compound 46)
Show SMILES Cc1nc2c(cc(nn2c1Nc1cccc(c1CN1CC(O)C1)C(F)(F)F)N1CCOCC1)-c1cnc[nH]1
Show InChI InChI=1S/C25H27F3N8O2/c1-15-23(32-20-4-2-3-19(25(26,27)28)18(20)13-34-11-16(37)12-34)36-24(31-15)17(21-10-29-14-30-21)9-22(33-36)35-5-7-38-8-6-35/h2-4,9-10,14,16,32,37H,5-8,11-13H2,1H3,(H,29,30)
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n/an/an/a 741n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM288347
PNG
(US10087187, Compound 37)
Show SMILES Cc1c(Nc2c(CO)nc3c(cc(nn23)N2CCOCC2)C(N)=O)cccc1C(F)(F)F
Show InChI InChI=1S/C20H21F3N6O3/c1-11-13(20(21,22)23)3-2-4-14(11)25-19-15(10-30)26-18-12(17(24)31)9-16(27-29(18)19)28-5-7-32-8-6-28/h2-4,9,25,30H,5-8,10H2,1H3,(H2,24,31)
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n/an/an/a 759n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM288394
PNG
(US10087187, Compound 89)
Show SMILES Cc1nc2c(cc(nn2c1Nc1ccccc1N1CCOCC1)N1CCOCC1)-c1ccn[nH]1
Show InChI InChI=1S/C24H28N8O2/c1-17-23(27-20-4-2-3-5-21(20)30-8-12-33-13-9-30)32-24(26-17)18(19-6-7-25-28-19)16-22(29-32)31-10-14-34-15-11-31/h2-7,16,27H,8-15H2,1H3,(H,25,28)
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n/an/an/a 851n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM288366
PNG
(US10087187, Compound 57)
Show SMILES CN1CCN(Cc2c(Nc3c(C)nc4c(cc(nn34)N3CCOCC3)-c3c[nH]cn3)cccc2C(F)(F)F)CC1
Show InChI InChI=1S/C27H32F3N9O/c1-18-25(34-22-5-3-4-21(27(28,29)30)20(22)16-37-8-6-36(2)7-9-37)39-26(33-18)19(23-15-31-17-32-23)14-24(35-39)38-10-12-40-13-11-38/h3-5,14-15,17,34H,6-13,16H2,1-2H3,(H,31,32)
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n/an/an/a 891n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM288351
PNG
(US10087187, Compound 41)
Show SMILES Cc1nc2c(cc(nn2c1Nc1cccc(c1CN1CCOCC1)C(F)(F)F)N1CCOCC1)-c1cnc[nH]1
Show InChI InChI=1S/C26H29F3N8O2/c1-17-24(33-21-4-2-3-20(26(27,28)29)19(21)15-35-5-9-38-10-6-35)37-25(32-17)18(22-14-30-16-31-22)13-23(34-37)36-7-11-39-12-8-36/h2-4,13-14,16,33H,5-12,15H2,1H3,(H,30,31)
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n/an/an/a 955n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM288311
PNG
(US10087187, Compound 4)
Show SMILES Cc1c(Cc2c(CNCCO)nc3c(cc(nn23)N2CCOCC2)-c2ncc[nH]2)cccc1C(F)(F)F
Show InChI InChI=1S/C25H28F3N7O2/c1-16-17(3-2-4-19(16)25(26,27)28)13-21-20(15-29-7-10-36)32-24-18(23-30-5-6-31-23)14-22(33-35(21)24)34-8-11-37-12-9-34/h2-6,14,29,36H,7-13,15H2,1H3,(H,30,31)
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n/an/an/a 1.15E+3n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM288359
PNG
(US10087187, Compound 50)
Show SMILES Cc1nc2c(cc(nn2c1Nc1cccc(F)c1C)N1CCOCC1)-c1c[nH]cn1
Show InChI InChI=1S/C21H22FN7O/c1-13-16(22)4-3-5-17(13)26-20-14(2)25-21-15(18-11-23-12-24-18)10-19(27-29(20)21)28-6-8-30-9-7-28/h3-5,10-12,26H,6-9H2,1-2H3,(H,23,24)
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n/an/an/a 1.26E+3n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50198027
PNG
(CHEMBL3921246)
Show SMILES CCc1ccc(cc1)\N=C1/S\C(=C/c2ccnc(Nc3ccc(cn3)C(O)=O)c2)C(=O)N1C
Show InChI InChI=1S/C24H21N5O3S/c1-3-15-4-7-18(8-5-15)27-24-29(2)22(30)19(33-24)12-16-10-11-25-21(13-16)28-20-9-6-17(14-26-20)23(31)32/h4-14H,3H2,1-2H3,(H,31,32)(H,25,26,28)/b19-12-,27-24-
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n/an/an/a 1.50E+3n/an/an/an/an/a



University of Berne

Curated by ChEMBL


Assay Description
Binding affinity to human PIK3CG expressed in Escherichia coli BL21 cells incubated for 1 hr by active site directed binding competition assay


J Med Chem 59: 7188-211 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00709
BindingDB Entry DOI: 10.7270/Q2JM2CM5
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM288329
PNG
(US10087187, Compound 19)
Show SMILES Cc1c(Cc2c(CO)nc3c(cc(nn23)N2CCOCC2)-c2cnc[nH]2)cccc1C(F)(F)F
Show InChI InChI=1S/C23H23F3N6O2/c1-14-15(3-2-4-17(14)23(24,25)26)9-20-19(12-33)29-22-16(18-11-27-13-28-18)10-21(30-32(20)22)31-5-7-34-8-6-31/h2-4,10-11,13,33H,5-9,12H2,1H3,(H,27,28)
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n/an/an/a 1.76E+3n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/an/a 1.80E+3n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for PIK3CG kinase domain


Nat Biotechnol 29: 1046-51 (2011)


Article DOI: 10.1038/nbt.1990
BindingDB Entry DOI: 10.7270/Q25D8S70
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50355500
PNG
(CHEMBL1908394 | US9695172, GSK461364)
Show SMILES C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2ccc(CN3CCN(C)CC3)cc12)c1ccccc1C(F)(F)F
Show InChI InChI=1S/C27H28F3N5O2S/c1-17(19-5-3-4-6-20(19)27(28,29)30)37-23-14-24(38-25(23)26(31)36)35-16-32-21-8-7-18(13-22(21)35)15-34-11-9-33(2)10-12-34/h3-8,13-14,16-17H,9-12,15H2,1-2H3,(H2,31,36)/t17-/m1/s1
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n/an/an/a 1.90E+3n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for PIK3CG kinase domain


Nat Biotechnol 29: 1046-51 (2011)


Article DOI: 10.1038/nbt.1990
BindingDB Entry DOI: 10.7270/Q25D8S70
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM288325
PNG
(US10087187, Compound 15)
Show SMILES Cc1c(Cc2c(CO)nc3c(cc(nn23)N2CCOCC2)C(N)=O)cccc1C(F)(F)F
Show InChI InChI=1S/C21H22F3N5O3/c1-12-13(3-2-4-15(12)21(22,23)24)9-17-16(11-30)26-20-14(19(25)31)10-18(27-29(17)20)28-5-7-32-8-6-28/h2-4,10,30H,5-9,11H2,1H3,(H2,25,31)
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n/an/an/a 2.00E+3n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM288344
PNG
(US10087187, Compound 34 | US10087187, Compound 35)
Show SMILES Cc1nc2c(cc(nn2c1Nc1cccc(c1C)C(F)(F)F)N1CCOCC1)-c1ncc[nH]1
Show InChI InChI=1S/C22H22F3N7O/c1-13-16(22(23,24)25)4-3-5-17(13)29-20-14(2)28-21-15(19-26-6-7-27-19)12-18(30-32(20)21)31-8-10-33-11-9-31/h3-7,12,29H,8-11H2,1-2H3,(H,26,27)
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n/an/an/a 2.29E+3n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50200976
PNG
(CHEMBL3946307)
Show SMILES Cc1nc2c(cc(nn2c1Nc1cccc(c1C)C(F)(F)F)N1CCOCC1)-c1cnc[nH]1
Show InChI InChI=1S/C22H22F3N7O/c1-13-16(22(23,24)25)4-3-5-17(13)29-20-14(2)28-21-15(18-11-26-12-27-18)10-19(30-32(20)21)31-6-8-33-9-7-31/h3-5,10-12,29H,6-9H2,1-2H3,(H,26,27)
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n/an/an/a 2.29E+3n/an/an/an/an/a



Dart Neuroscience LLC

Curated by ChEMBL


Assay Description
Binding affinity to human PI3Kgamma (144 to 1102 residues) expressed in mammalian expression system by KINOMEscan assay


ACS Med Chem Lett 7: 1012-1013 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00406
BindingDB Entry DOI: 10.7270/Q2N29ZX9
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM288352
PNG
(US10087187, Compound 42)
Show SMILES Cc1nc2c(cc(nn2c1Nc1cccc2CCNCc12)N1CCOCC1)-c1cnc[nH]1
Show InChI InChI=1S/C23H26N8O/c1-15-22(28-19-4-2-3-16-5-6-24-12-18(16)19)31-23(27-15)17(20-13-25-14-26-20)11-21(29-31)30-7-9-32-10-8-30/h2-4,11,13-14,24,28H,5-10,12H2,1H3,(H,25,26)
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n/an/an/a 2.29E+3n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM288408
PNG
(US10087187, Compound 109)
Show SMILES Cc1nc2c(N)cc(nn2c1Cc1cccc2CCNCc12)N1CCOCC1
Show InChI InChI=1S/C21H26N6O/c1-14-19(11-16-4-2-3-15-5-6-23-13-17(15)16)27-21(24-14)18(22)12-20(25-27)26-7-9-28-10-8-26/h2-4,12,23H,5-11,13,22H2,1H3
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US Patent
n/an/an/a 2.90E+3n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM288326
PNG
(US10087187, Compound 16)
Show SMILES Cc1c(Cc2c(CF)nc3c(cc(nn23)N2CCOCC2)C(N)=O)cccc1C(F)(F)F
Show InChI InChI=1S/C21H21F4N5O2/c1-12-13(3-2-4-15(12)21(23,24)25)9-17-16(11-22)27-20-14(19(26)31)10-18(28-30(17)20)29-5-7-32-8-6-29/h2-4,10H,5-9,11H2,1H3,(H2,26,31)
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n/an/an/a>3.31E+3n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM288399
PNG
(US10087187, Compound 99)
Show SMILES CCc1c(F)cccc1Cc1c(CO)nc2c(N)cc(nn12)N1CCOCC1
Show InChI InChI=1S/C20H24FN5O2/c1-2-14-13(4-3-5-15(14)21)10-18-17(12-27)23-20-16(22)11-19(24-26(18)20)25-6-8-28-9-7-25/h3-5,11,27H,2,6-10,12,22H2,1H3
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US Patent
n/an/an/a 3.31E+3n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM288334
PNG
(US10087187, Compound 24)
Show SMILES Cc1c(Cc2c(CCO)nc3c(cc(nn23)N2CCOCC2)-c2c[nH]cn2)cccc1C(F)(F)F
Show InChI InChI=1S/C24H25F3N6O2/c1-15-16(3-2-4-18(15)24(25,26)27)11-21-19(5-8-34)30-23-17(20-13-28-14-29-20)12-22(31-33(21)23)32-6-9-35-10-7-32/h2-4,12-14,34H,5-11H2,1H3,(H,28,29)
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n/an/an/a 3.36E+3n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM288368
PNG
(US10087187, Compound 59)
Show SMILES Cc1nc2c(N)cc(nn2c1Nc1cccc(c1C1CCNCC1)C(F)(F)F)N1CCOCC1
Show InChI InChI=1S/C23H28F3N7O/c1-14-21(33-22(29-14)17(27)13-19(31-33)32-9-11-34-12-10-32)30-18-4-2-3-16(23(24,25)26)20(18)15-5-7-28-8-6-15/h2-4,13,15,28,30H,5-12,27H2,1H3
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n/an/an/a 3.39E+3n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM288320
PNG
(US10087187, Compound 13)
Show SMILES Cc1nc2c(cc(nn2c1Cc1cccc(Cl)c1C)N1CCOCC1)C(O)=O
Show InChI InChI=1S/C20H21ClN4O3/c1-12-14(4-3-5-16(12)21)10-17-13(2)22-19-15(20(26)27)11-18(23-25(17)19)24-6-8-28-9-7-24/h3-5,11H,6-10H2,1-2H3,(H,26,27)
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n/an/an/a 3.55E+3n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM288392
PNG
(US10087187, Compound 87)
Show SMILES Cc1nc2c(cc(nn2c1Nc1ccccc1N1CCOCC1)N1CCOCC1)C(N)=O
Show InChI InChI=1S/C22H27N7O3/c1-15-21(25-17-4-2-3-5-18(17)27-6-10-31-11-7-27)29-22(24-15)16(20(23)30)14-19(26-29)28-8-12-32-13-9-28/h2-5,14,25H,6-13H2,1H3,(H2,23,30)
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n/an/an/a 3.63E+3n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM288398
PNG
(US10087187, Compound 97)
Show SMILES Cc1c(F)cccc1Cc1c(CNCCO)nc2c(N)cc(nn12)N1CCOCC1
Show InChI InChI=1S/C21H27FN6O2/c1-14-15(3-2-4-16(14)22)11-19-18(13-24-5-8-29)25-21-17(23)12-20(26-28(19)21)27-6-9-30-10-7-27/h2-4,12,24,29H,5-11,13,23H2,1H3
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n/an/an/a 3.72E+3n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM288396
PNG
(US10087187, Compound 93)
Show SMILES Cc1c(F)cccc1Cc1c(CO)nc2c(N)cc(nn12)N1CCOCC1
Show InChI InChI=1S/C19H22FN5O2/c1-12-13(3-2-4-14(12)20)9-17-16(11-26)22-19-15(21)10-18(23-25(17)19)24-5-7-27-8-6-24/h2-4,10,26H,5-9,11,21H2,1H3
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n/an/an/a 3.89E+3n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM288350
PNG
(US10087187, Compound 40)
Show SMILES Cc1nc2c(cc(nn2c1Nc1cccc(c1C)C(F)(F)F)N1CCOCC1)C(N)=O
Show InChI InChI=1S/C20H21F3N6O2/c1-11-14(20(21,22)23)4-3-5-15(11)26-18-12(2)25-19-13(17(24)30)10-16(27-29(18)19)28-6-8-31-9-7-28/h3-5,10,26H,6-9H2,1-2H3,(H2,24,30)
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n/an/an/a 3.90E+3n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM288346
PNG
(US10087187, Compound 36)
Show SMILES Cc1nc2c(cc(nn2c1Nc1cccc(c1C)C(F)(F)F)N1CCOCC1)C(O)=O
Show InChI InChI=1S/C20H20F3N5O3/c1-11-14(20(21,22)23)4-3-5-15(11)25-17-12(2)24-18-13(19(29)30)10-16(26-28(17)18)27-6-8-31-9-7-27/h3-5,10,25H,6-9H2,1-2H3,(H,29,30)
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n/an/an/a 4.05E+3n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM288340
PNG
(US10087187, Compound 30)
Show SMILES CC(O)c1nc2c(cc(nn2c1Cc1cccc(c1C)C(F)(F)F)N1CCOCC1)-c1c[nH]cn1
Show InChI InChI=1S/C24H25F3N6O2/c1-14-16(4-3-5-18(14)24(25,26)27)10-20-22(15(2)34)30-23-17(19-12-28-13-29-19)11-21(31-33(20)23)32-6-8-35-9-7-32/h3-5,11-13,15,34H,6-10H2,1-2H3,(H,28,29)
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n/an/an/a 4.57E+3n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50200970
PNG
(CHEMBL3955003 | US10087187, Compound 52)
Show SMILES Cc1nc2c(N)cc(nn2c1Nc1cccc(c1CN1CC(O)C1)C(F)(F)F)N1CCOCC1
Show InChI InChI=1S/C22H26F3N7O2/c1-13-20(32-21(27-13)17(26)9-19(29-32)31-5-7-34-8-6-31)28-18-4-2-3-16(22(23,24)25)15(18)12-30-10-14(33)11-30/h2-4,9,14,28,33H,5-8,10-12,26H2,1H3
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US Patent
n/an/an/a 4.79E+3n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
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