BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 132 hits Enz. Inhib. hit(s) with Target = 'Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha


(Homo sapiens (Human))
BDBM288376
PNG
(US10087187, Compound 67)
Show SMILES Cc1c(Cl)cccc1Nc1c(CO)nc2c(cc(nn12)N1CCOCC1)-c1c[nH]cn1
Show InChI InChI=1S/C21H22ClN7O2/c1-13-15(22)3-2-4-16(13)25-21-18(11-30)26-20-14(17-10-23-12-24-17)9-19(27-29(20)21)28-5-7-31-8-6-28/h2-4,9-10,12,25,30H,5-8,11H2,1H3,(H,23,24)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 195n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha


(Homo sapiens (Human))
BDBM288351
PNG
(US10087187, Compound 41)
Show SMILES Cc1nc2c(cc(nn2c1Nc1cccc(c1CN1CCOCC1)C(F)(F)F)N1CCOCC1)-c1cnc[nH]1
Show InChI InChI=1S/C26H29F3N8O2/c1-17-24(33-21-4-2-3-20(26(27,28)29)19(21)15-35-5-9-38-10-6-35)37-25(32-17)18(22-14-30-16-31-22)13-23(34-37)36-7-11-39-12-8-36/h2-4,13-14,16,33H,5-12,15H2,1H3,(H,30,31)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 275n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha


(Homo sapiens (Human))
BDBM288366
PNG
(US10087187, Compound 57)
Show SMILES CN1CCN(Cc2c(Nc3c(C)nc4c(cc(nn34)N3CCOCC3)-c3c[nH]cn3)cccc2C(F)(F)F)CC1
Show InChI InChI=1S/C27H32F3N9O/c1-18-25(34-22-5-3-4-21(27(28,29)30)20(22)16-37-8-6-36(2)7-9-37)39-26(33-18)19(23-15-31-17-32-23)14-24(35-39)38-10-12-40-13-11-38/h3-5,14-15,17,34H,6-13,16H2,1-2H3,(H,31,32)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 339n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha


(Homo sapiens (Human))
BDBM288352
PNG
(US10087187, Compound 42)
Show SMILES Cc1nc2c(cc(nn2c1Nc1cccc2CCNCc12)N1CCOCC1)-c1cnc[nH]1
Show InChI InChI=1S/C23H26N8O/c1-15-22(28-19-4-2-3-16-5-6-24-12-18(16)19)31-23(27-15)17(20-13-25-14-26-20)11-21(29-31)30-7-9-32-10-8-30/h2-4,11,13-14,24,28H,5-10,12H2,1H3,(H,25,26)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 347n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha


(Homo sapiens (Human))
BDBM288320
PNG
(US10087187, Compound 13)
Show SMILES Cc1nc2c(cc(nn2c1Cc1cccc(Cl)c1C)N1CCOCC1)C(O)=O
Show InChI InChI=1S/C20H21ClN4O3/c1-12-14(4-3-5-16(12)21)10-17-13(2)22-19-15(20(26)27)11-18(23-25(17)19)24-6-8-28-9-7-24/h3-5,11H,6-10H2,1-2H3,(H,26,27)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 525n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha


(Homo sapiens (Human))
BDBM288359
PNG
(US10087187, Compound 50)
Show SMILES Cc1nc2c(cc(nn2c1Nc1cccc(F)c1C)N1CCOCC1)-c1c[nH]cn1
Show InChI InChI=1S/C21H22FN7O/c1-13-16(22)4-3-5-17(13)26-20-14(2)25-21-15(18-11-23-12-24-18)10-19(27-29(20)21)28-6-8-30-9-7-28/h3-5,10-12,26H,6-9H2,1-2H3,(H,23,24)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 537n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha


(Homo sapiens (Human))
BDBM288347
PNG
(US10087187, Compound 37)
Show SMILES Cc1c(Nc2c(CO)nc3c(cc(nn23)N2CCOCC2)C(N)=O)cccc1C(F)(F)F
Show InChI InChI=1S/C20H21F3N6O3/c1-11-13(20(21,22)23)3-2-4-14(11)25-19-15(10-30)26-18-12(17(24)31)9-16(27-29(18)19)28-5-7-32-8-6-28/h2-4,9,25,30H,5-8,10H2,1H3,(H2,24,31)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 575n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha


(Homo sapiens (Human))
BDBM288335
PNG
(US10087187, Compound 25 | US10087187, Compound 27)
Show SMILES CC1CN(CCO1)c1cc(-c2c[nH]cn2)c2nc(CO)c(Cc3cccc(c3C)C(F)(F)F)n2n1
Show InChI InChI=1S/C24H25F3N6O2/c1-14-11-32(6-7-35-14)22-9-17(19-10-28-13-29-19)23-30-20(12-34)21(33(23)31-22)8-16-4-3-5-18(15(16)2)24(25,26)27/h3-5,9-10,13-14,34H,6-8,11-12H2,1-2H3,(H,28,29)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 617n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha


(Homo sapiens (Human))
BDBM50200977
PNG
(CHEMBL3986383 | US10087187, Compound 5)
Show SMILES Cc1nc2c(cc(nn2c1Cc1cccc(c1C)C(F)(F)F)N1CCOCC1)-c1cnc[nH]1
Show InChI InChI=1S/C23H23F3N6O/c1-14-16(4-3-5-18(14)23(24,25)26)10-20-15(2)29-22-17(19-12-27-13-28-19)11-21(30-32(20)22)31-6-8-33-9-7-31/h3-5,11-13H,6-10H2,1-2H3,(H,27,28)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 617n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha


(Homo sapiens (Human))
BDBM288394
PNG
(US10087187, Compound 89)
Show SMILES Cc1nc2c(cc(nn2c1Nc1ccccc1N1CCOCC1)N1CCOCC1)-c1ccn[nH]1
Show InChI InChI=1S/C24H28N8O2/c1-17-23(27-20-4-2-3-5-21(20)30-8-12-33-13-9-30)32-24(26-17)18(19-6-7-25-28-19)16-22(29-32)31-10-14-34-15-11-31/h2-7,16,27H,8-15H2,1H3,(H,25,28)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 631n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha


(Homo sapiens (Human))
BDBM50200968
PNG
(CHEMBL3983623 | US10087187, Compound 46)
Show SMILES Cc1nc2c(cc(nn2c1Nc1cccc(c1CN1CC(O)C1)C(F)(F)F)N1CCOCC1)-c1cnc[nH]1
Show InChI InChI=1S/C25H27F3N8O2/c1-15-23(32-20-4-2-3-19(25(26,27)28)18(20)13-34-11-16(37)12-34)36-24(31-15)17(21-10-29-14-30-21)9-22(33-36)35-5-7-38-8-6-35/h2-4,9-10,14,16,32,37H,5-8,11-13H2,1H3,(H,29,30)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/an/a 661n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha


(Homo sapiens (Human))
BDBM288346
PNG
(US10087187, Compound 36)
Show SMILES Cc1nc2c(cc(nn2c1Nc1cccc(c1C)C(F)(F)F)N1CCOCC1)C(O)=O
Show InChI InChI=1S/C20H20F3N5O3/c1-11-14(20(21,22)23)4-3-5-15(11)25-17-12(2)24-18-13(19(29)30)10-16(26-28(17)18)27-6-8-31-9-7-27/h3-5,10,25H,6-9H2,1-2H3,(H,29,30)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 669n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha


(Homo sapiens (Human))
BDBM288329
PNG
(US10087187, Compound 19)
Show SMILES Cc1c(Cc2c(CO)nc3c(cc(nn23)N2CCOCC2)-c2cnc[nH]2)cccc1C(F)(F)F
Show InChI InChI=1S/C23H23F3N6O2/c1-14-15(3-2-4-17(14)23(24,25)26)9-20-19(12-33)29-22-16(18-11-27-13-28-18)10-21(30-32(20)22)31-5-7-34-8-6-31/h2-4,10-11,13,33H,5-9,12H2,1H3,(H,27,28)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 886n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha


(Homo sapiens (Human))
BDBM288344
PNG
(US10087187, Compound 34 | US10087187, Compound 35)
Show SMILES Cc1nc2c(cc(nn2c1Nc1cccc(c1C)C(F)(F)F)N1CCOCC1)-c1ncc[nH]1
Show InChI InChI=1S/C22H22F3N7O/c1-13-16(22(23,24)25)4-3-5-17(13)29-20-14(2)28-21-15(19-26-6-7-27-19)12-18(30-32(20)21)31-8-10-33-11-9-31/h3-7,12,29H,8-11H2,1-2H3,(H,26,27)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 912n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha


(Homo sapiens (Human))
BDBM288311
PNG
(US10087187, Compound 4)
Show SMILES Cc1c(Cc2c(CNCCO)nc3c(cc(nn23)N2CCOCC2)-c2ncc[nH]2)cccc1C(F)(F)F
Show InChI InChI=1S/C25H28F3N7O2/c1-16-17(3-2-4-19(16)25(26,27)28)13-21-20(15-29-7-10-36)32-24-18(23-30-5-6-31-23)14-22(33-35(21)24)34-8-11-37-12-9-34/h2-6,14,29,36H,7-13,15H2,1H3,(H,30,31)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 933n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha


(Homo sapiens (Human))
BDBM288319
PNG
(US10087187, Compound 12)
Show SMILES Cc1nc2c(cc(nn2c1Cc1cccc(C)c1C)N1CCOCC1)C(O)=O
Show InChI InChI=1S/C21H24N4O3/c1-13-5-4-6-16(14(13)2)11-18-15(3)22-20-17(21(26)27)12-19(23-25(18)20)24-7-9-28-10-8-24/h4-6,12H,7-11H2,1-3H3,(H,26,27)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 1.07E+3n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha


(Homo sapiens (Human))
BDBM288325
PNG
(US10087187, Compound 15)
Show SMILES Cc1c(Cc2c(CO)nc3c(cc(nn23)N2CCOCC2)C(N)=O)cccc1C(F)(F)F
Show InChI InChI=1S/C21H22F3N5O3/c1-12-13(3-2-4-15(12)21(22,23)24)9-17-16(11-30)26-20-14(19(25)31)10-18(27-29(17)20)28-5-7-32-8-6-28/h2-4,10,30H,5-9,11H2,1H3,(H2,25,31)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 1.10E+3n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha


(Homo sapiens (Human))
BDBM288334
PNG
(US10087187, Compound 24)
Show SMILES Cc1c(Cc2c(CCO)nc3c(cc(nn23)N2CCOCC2)-c2c[nH]cn2)cccc1C(F)(F)F
Show InChI InChI=1S/C24H25F3N6O2/c1-15-16(3-2-4-18(15)24(25,26)27)11-21-19(5-8-34)30-23-17(20-13-28-14-29-20)12-22(31-33(21)23)32-6-9-35-10-7-32/h2-4,12-14,34H,5-11H2,1H3,(H,28,29)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 1.11E+3n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha


(Homo sapiens (Human))
BDBM288364
PNG
(US10087187, Compound 55 | US10087187, Compound 56)
Show SMILES CC(CO)NCc1c(Nc2c(C)nc3c(N)cc(nn23)N2CCOCC2)cccc1C(F)(F)F
Show InChI InChI=1S/C22H28F3N7O2/c1-13(12-33)27-11-15-16(22(23,24)25)4-3-5-18(15)29-20-14(2)28-21-17(26)10-19(30-32(20)21)31-6-8-34-9-7-31/h3-5,10,13,27,29,33H,6-9,11-12,26H2,1-2H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 1.12E+3n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha


(Homo sapiens (Human))
BDBM288340
PNG
(US10087187, Compound 30)
Show SMILES CC(O)c1nc2c(cc(nn2c1Cc1cccc(c1C)C(F)(F)F)N1CCOCC1)-c1c[nH]cn1
Show InChI InChI=1S/C24H25F3N6O2/c1-14-16(4-3-5-18(14)24(25,26)27)10-20-22(15(2)34)30-23-17(19-12-28-13-29-19)11-21(31-33(20)23)32-6-8-35-9-7-32/h3-5,11-13,15,34H,6-10H2,1-2H3,(H,28,29)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 1.18E+3n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha


(Homo sapiens (Human))
BDBM288392
PNG
(US10087187, Compound 87)
Show SMILES Cc1nc2c(cc(nn2c1Nc1ccccc1N1CCOCC1)N1CCOCC1)C(N)=O
Show InChI InChI=1S/C22H27N7O3/c1-15-21(25-17-4-2-3-5-18(17)27-6-10-31-11-7-27)29-22(24-15)16(20(23)30)14-19(26-29)28-8-12-32-13-9-28/h2-5,14,25H,6-13H2,1H3,(H2,23,30)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 1.20E+3n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha


(Homo sapiens (Human))
BDBM50200969
PNG
(CHEMBL3970860 | US10087187, Compound 9)
Show SMILES Cc1nc2c(cc(nn2c1Cc1cccc(c1C)C(F)(F)F)N1CCOCC1)C(O)=O
Show InChI InChI=1S/C21H21F3N4O3/c1-12-14(4-3-5-16(12)21(22,23)24)10-17-13(2)25-19-15(20(29)30)11-18(26-28(17)19)27-6-8-31-9-7-27/h3-5,11H,6-10H2,1-2H3,(H,29,30)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/an/a 1.35E+3n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha


(Homo sapiens (Human))
BDBM288331
PNG
(US10087187, Compound 21)
Show SMILES Cc1c(Cc2c(CO)nc3c(cc(nn23)N2CCOCC2)-c2ccn[nH]2)cccc1C(F)(F)F
Show InChI InChI=1S/C23H23F3N6O2/c1-14-15(3-2-4-17(14)23(24,25)26)11-20-19(13-33)28-22-16(18-5-6-27-29-18)12-21(30-32(20)22)31-7-9-34-10-8-31/h2-6,12,33H,7-11,13H2,1H3,(H,27,29)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 1.59E+3n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha


(Homo sapiens (Human))
BDBM50200972
PNG
(CHEMBL3974658 | US10087187, Compound 22)
Show SMILES Cc1c(Cc2c(CO)nc3c(cc(nn23)N2CCOCC2)C(O)=O)cccc1C(F)(F)F
Show InChI InChI=1S/C21H21F3N4O4/c1-12-13(3-2-4-15(12)21(22,23)24)9-17-16(11-29)25-19-14(20(30)31)10-18(26-28(17)19)27-5-7-32-8-6-27/h2-4,10,29H,5-9,11H2,1H3,(H,30,31)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/an/a 1.59E+3n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha


(Homo sapiens (Human))
BDBM288330
PNG
(US10087187, Compound 20)
Show SMILES Cc1c(Cc2c(CO)nc3c(cc(nn23)N2CCOCC2)-c2ncc[nH]2)cccc1C(F)(F)F
Show InChI InChI=1S/C23H23F3N6O2/c1-14-15(3-2-4-17(14)23(24,25)26)11-19-18(13-33)29-22-16(21-27-5-6-28-21)12-20(30-32(19)22)31-7-9-34-10-8-31/h2-6,12,33H,7-11,13H2,1H3,(H,27,28)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 1.70E+3n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha


(Homo sapiens (Human))
BDBM288364
PNG
(US10087187, Compound 55 | US10087187, Compound 56)
Show SMILES CC(CO)NCc1c(Nc2c(C)nc3c(N)cc(nn23)N2CCOCC2)cccc1C(F)(F)F
Show InChI InChI=1S/C22H28F3N7O2/c1-13(12-33)27-11-15-16(22(23,24)25)4-3-5-18(15)29-20-14(2)28-21-17(26)10-19(30-32(20)21)31-6-8-34-9-7-31/h3-5,10,13,27,29,33H,6-9,11-12,26H2,1-2H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 1.71E+3n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha


(Homo sapiens (Human))
BDBM288391
PNG
(US10087187, Compound 86)
Show SMILES Cc1nc2c(cc(nn2c1Nc1ccccc1N1CCOCC1)N1CCOCC1)C(O)=O
Show InChI InChI=1S/C22H26N6O4/c1-15-20(24-17-4-2-3-5-18(17)26-6-10-31-11-7-26)28-21(23-15)16(22(29)30)14-19(25-28)27-8-12-32-13-9-27/h2-5,14,24H,6-13H2,1H3,(H,29,30)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 1.78E+3n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha


(Homo sapiens (Human))
BDBM288350
PNG
(US10087187, Compound 40)
Show SMILES Cc1nc2c(cc(nn2c1Nc1cccc(c1C)C(F)(F)F)N1CCOCC1)C(N)=O
Show InChI InChI=1S/C20H21F3N6O2/c1-11-14(20(21,22)23)4-3-5-15(11)26-18-12(2)25-19-13(17(24)30)10-16(27-29(18)19)28-6-8-31-9-7-28/h3-5,10,26H,6-9H2,1-2H3,(H2,24,30)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 2.04E+3n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha


(Homo sapiens (Human))
BDBM288338
PNG
(US10087187, Compound 28)
Show SMILES CC1CN(CCO1)c1cc(C(O)=O)c2nc(C)c(Cc3cccc(c3C)C(F)(F)F)n2n1
Show InChI InChI=1S/C22H23F3N4O3/c1-12-11-28(7-8-32-12)19-10-16(21(30)31)20-26-14(3)18(29(20)27-19)9-15-5-4-6-17(13(15)2)22(23,24)25/h4-6,10,12H,7-9,11H2,1-3H3,(H,30,31)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 2.09E+3n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha


(Homo sapiens (Human))
BDBM288344
PNG
(US10087187, Compound 34 | US10087187, Compound 35)
Show SMILES Cc1nc2c(cc(nn2c1Nc1cccc(c1C)C(F)(F)F)N1CCOCC1)-c1ncc[nH]1
Show InChI InChI=1S/C22H22F3N7O/c1-13-16(22(23,24)25)4-3-5-17(13)29-20-14(2)28-21-15(19-26-6-7-27-19)12-18(30-32(20)21)31-8-10-33-11-9-31/h3-7,12,29H,8-11H2,1-2H3,(H,26,27)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 2.24E+3n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha


(Homo sapiens (Human))
BDBM288341
PNG
(US10087187, Compound 31)
Show SMILES CC(O)c1nc2c(cc(nn2c1Cc1cccc(c1C)C(F)(F)F)N1CCOCC1)-c1ncc[nH]1
Show InChI InChI=1S/C24H25F3N6O2/c1-14-16(4-3-5-18(14)24(25,26)27)12-19-21(15(2)34)30-23-17(22-28-6-7-29-22)13-20(31-33(19)23)32-8-10-35-11-9-32/h3-7,13,15,34H,8-12H2,1-2H3,(H,28,29)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 2.29E+3n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha


(Homo sapiens (Human))
BDBM288349
PNG
(US10087187, Compound 39)
Show SMILES Cc1nc2c(N)cc(nn2c1Nc1cccc(C)c1C)N1CCOCC1
Show InChI InChI=1S/C19H24N6O/c1-12-5-4-6-16(13(12)2)22-18-14(3)21-19-15(20)11-17(23-25(18)19)24-7-9-26-10-8-24/h4-6,11,22H,7-10,20H2,1-3H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 2.57E+3n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha


(Homo sapiens (Human))
BDBM288318
PNG
(US10087187, Compound 11)
Show SMILES Cc1nc2c(cc(nn2c1Cc1cccc(Cl)c1C)N1CCOCC1)C(N)=O
Show InChI InChI=1S/C20H22ClN5O2/c1-12-14(4-3-5-16(12)21)10-17-13(2)23-20-15(19(22)27)11-18(24-26(17)20)25-6-8-28-9-7-25/h3-5,11H,6-10H2,1-2H3,(H2,22,27)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 2.69E+3n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha


(Homo sapiens (Human))
BDBM288405
PNG
(US10087187, Compound 106)
Show SMILES Cc1nc2c(N)cc(nn2c1Cc1cccc(F)c1C1CCNCC1)N1CCOCC1
Show InChI InChI=1S/C23H29FN6O/c1-15-20(13-17-3-2-4-18(24)22(17)16-5-7-26-8-6-16)30-23(27-15)19(25)14-21(28-30)29-9-11-31-12-10-29/h2-4,14,16,26H,5-13,25H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 2.75E+3n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha


(Homo sapiens (Human))
BDBM288377
PNG
(US10087187, Compound 68)
Show SMILES Cc1c(Nc2c(CO)nc3c(cc(nn23)N2CCOC(CO)C2)-c2c[nH]cn2)cccc1C(F)(F)F
Show InChI InChI=1S/C23H24F3N7O3/c1-13-16(23(24,25)26)3-2-4-17(13)29-22-19(11-35)30-21-15(18-8-27-12-28-18)7-20(31-33(21)22)32-5-6-36-14(9-32)10-34/h2-4,7-8,12,14,29,34-35H,5-6,9-11H2,1H3,(H,27,28)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 2.75E+3n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha


(Homo sapiens (Human))
BDBM288357
PNG
(US10087187, Compound 48)
Show SMILES Cc1nc2c(N)cc(nn2c1Nc1cccc(c1CN1CC(C1)S(C)(=O)=O)C(F)(F)F)N1CCOCC1
Show InChI InChI=1S/C23H28F3N7O3S/c1-14-21(33-22(28-14)18(27)10-20(30-33)32-6-8-36-9-7-32)29-19-5-3-4-17(23(24,25)26)16(19)13-31-11-15(12-31)37(2,34)35/h3-5,10,15,29H,6-9,11-13,27H2,1-2H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 2.75E+3n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha


(Homo sapiens (Human))
BDBM288381
PNG
(US10087187, Compound 74 | US10087187, Compound 77 ...)
Show SMILES Cc1nc2c(N)cc(nn2c1Nc1cccc(c1CN1CCC(O)C1)C(F)(F)F)N1CCOCC1
Show InChI InChI=1S/C23H28F3N7O2/c1-14-21(33-22(28-14)18(27)11-20(30-33)32-7-9-35-10-8-32)29-19-4-2-3-17(23(24,25)26)16(19)13-31-6-5-15(34)12-31/h2-4,11,15,29,34H,5-10,12-13,27H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 3.16E+3n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha


(Homo sapiens (Human))
BDBM288381
PNG
(US10087187, Compound 74 | US10087187, Compound 77 ...)
Show SMILES Cc1nc2c(N)cc(nn2c1Nc1cccc(c1CN1CCC(O)C1)C(F)(F)F)N1CCOCC1
Show InChI InChI=1S/C23H28F3N7O2/c1-14-21(33-22(28-14)18(27)11-20(30-33)32-7-9-35-10-8-32)29-19-4-2-3-17(23(24,25)26)16(19)13-31-6-5-15(34)12-31/h2-4,11,15,29,34H,5-10,12-13,27H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 3.24E+3n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha


(Homo sapiens (Human))
BDBM288380
PNG
(US10087187, Compound 73)
Show SMILES Cc1nc2c(N)cc(nn2c1Nc1cccc(c1C1CCN(CCO)CC1)C(F)(F)F)N1CCOCC1
Show InChI InChI=1S/C25H32F3N7O2/c1-16-23(35-24(30-16)19(29)15-21(32-35)34-10-13-37-14-11-34)31-20-4-2-3-18(25(26,27)28)22(20)17-5-7-33(8-6-17)9-12-36/h2-4,15,17,31,36H,5-14,29H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 3.24E+3n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha


(Homo sapiens (Human))
BDBM288353
PNG
(US10087187, Compound 43)
Show SMILES Cc1nc2c(N)cc(nn2c1Nc1cccc(c1CN1CCS(=O)(=O)CC1)C(F)(F)F)N1CCOCC1
Show InChI InChI=1S/C23H28F3N7O3S/c1-15-21(33-22(28-15)18(27)13-20(30-33)32-5-9-36-10-6-32)29-19-4-2-3-17(23(24,25)26)16(19)14-31-7-11-37(34,35)12-8-31/h2-4,13,29H,5-12,14,27H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 3.31E+3n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha


(Homo sapiens (Human))
BDBM288314
PNG
(US10087187, Compound 7)
Show SMILES Cc1nc2c(cc(nn2c1Cc1cccc(c1C)C(F)(F)F)N1CCOCC1)-c1ncc[nH]1
Show InChI InChI=1S/C23H23F3N6O/c1-14-16(4-3-5-18(14)23(24,25)26)12-19-15(2)29-22-17(21-27-6-7-28-21)13-20(30-32(19)22)31-8-10-33-11-9-31/h3-7,13H,8-12H2,1-2H3,(H,27,28)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a>3.31E+3n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha


(Homo sapiens (Human))
BDBM288339
PNG
(US10087187, Compound 29)
Show SMILES Cc1nc2c(cc(nn2c1Cc1cccc(c1C)C(F)(F)F)C1=CCOCC1)C(O)=O
Show InChI InChI=1S/C22H20F3N3O3/c1-12-15(4-3-5-17(12)22(23,24)25)10-19-13(2)26-20-16(21(29)30)11-18(27-28(19)20)14-6-8-31-9-7-14/h3-6,11H,7-10H2,1-2H3,(H,29,30)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 3.39E+3n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha


(Homo sapiens (Human))
BDBM288348
PNG
(US10087187, Compound 38)
Show SMILES Cc1nc2c(N)cc(nn2c1Nc1cccc(c1CN1CCOCC1)C(F)(F)F)N1CCOCC1
Show InChI InChI=1S/C23H28F3N7O2/c1-15-21(33-22(28-15)18(27)13-20(30-33)32-7-11-35-12-8-32)29-19-4-2-3-17(23(24,25)26)16(19)14-31-5-9-34-10-6-31/h2-4,13,29H,5-12,14,27H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 4.05E+3n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha


(Homo sapiens (Human))
BDBM288372
PNG
(US10087187, Compound 63)
Show SMILES Cc1nc2c(N)cc(nn2c1Nc1cccc(F)c1CN1CCOCC1)N1CCOCC1
Show InChI InChI=1S/C22H28FN7O2/c1-15-21(26-19-4-2-3-17(23)16(19)14-28-5-9-31-10-6-28)30-22(25-15)18(24)13-20(27-30)29-7-11-32-12-8-29/h2-4,13,26H,5-12,14,24H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 4.17E+3n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha


(Homo sapiens (Human))
BDBM50200978
PNG
(CHEMBL3956037 | US10087187, Compound 58)
Show SMILES CN1CCN(Cc2c(Nc3c(C)nc4c(N)cc(nn34)N3CCOCC3)cccc2C(F)(F)F)CC1
Show InChI InChI=1S/C24H31F3N8O/c1-16-22(35-23(29-16)19(28)14-21(31-35)34-10-12-36-13-11-34)30-20-5-3-4-18(24(25,26)27)17(20)15-33-8-6-32(2)7-9-33/h3-5,14,30H,6-13,15,28H2,1-2H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/an/a 4.27E+3n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha


(Homo sapiens (Human))
BDBM288381
PNG
(US10087187, Compound 74 | US10087187, Compound 77 ...)
Show SMILES Cc1nc2c(N)cc(nn2c1Nc1cccc(c1CN1CCC(O)C1)C(F)(F)F)N1CCOCC1
Show InChI InChI=1S/C23H28F3N7O2/c1-14-21(33-22(28-14)18(27)11-20(30-33)32-7-9-35-10-8-32)29-19-4-2-3-17(23(24,25)26)16(19)13-31-6-5-15(34)12-31/h2-4,11,15,29,34H,5-10,12-13,27H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 4.90E+3n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha


(Homo sapiens (Human))
BDBM288343
PNG
(US10087187, Compound 33)
Show SMILES Cc1nc2c(N)cc(nn2c1Nc1cccc(c1C)C(F)(F)F)N1CCOCC1
Show InChI InChI=1S/C19H21F3N6O/c1-11-13(19(20,21)22)4-3-5-15(11)25-17-12(2)24-18-14(23)10-16(26-28(17)18)27-6-8-29-9-7-27/h3-5,10,25H,6-9,23H2,1-2H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 5.13E+3n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha


(Homo sapiens (Human))
BDBM288378
PNG
(US10087187, Compound 69)
Show SMILES Cc1nc2c(N)cc(nn2c1Nc1ccccc1CN1CCOCC1)N1CCOCC1
Show InChI InChI=1S/C22H29N7O2/c1-16-21(25-19-5-3-2-4-17(19)15-27-6-10-30-11-7-27)29-22(24-16)18(23)14-20(26-29)28-8-12-31-13-9-28/h2-5,14,25H,6-13,15,23H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 5.37E+3n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha


(Homo sapiens (Human))
BDBM50200970
PNG
(CHEMBL3955003 | US10087187, Compound 52)
Show SMILES Cc1nc2c(N)cc(nn2c1Nc1cccc(c1CN1CC(O)C1)C(F)(F)F)N1CCOCC1
Show InChI InChI=1S/C22H26F3N7O2/c1-13-20(32-21(27-13)17(26)9-19(29-32)31-5-7-34-8-6-31)28-18-4-2-3-16(22(23,24)25)15(18)12-30-10-14(33)11-30/h2-4,9,14,28,33H,5-8,10-12,26H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/an/a 5.75E+3n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha


(Homo sapiens (Human))
BDBM288400
PNG
(US10087187, Compound 101)
Show SMILES CCc1c(F)cccc1Cc1c(CNCCO)nc2c(N)cc(nn12)N1CCOCC1
Show InChI InChI=1S/C22H29FN6O2/c1-2-16-15(4-3-5-17(16)23)12-20-19(14-25-6-9-30)26-22-18(24)13-21(27-29(20)22)28-7-10-31-11-8-28/h3-5,13,25,30H,2,6-12,14,24H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 5.89E+3n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...


US Patent US10087187 (2018)

More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 132 total )  |  Next  |  Last  >>
Jump to: