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Compile Data Set for Download or QSAR

Found 2336 hits Enz. Inhib. hit(s) with Target = 'Phospholipase A2'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cPLA2 C2


(Homo sapiens (human))
BDBM50205515
PNG
(4-(2-(1-benzhydryl-5-chloro-2-(2-((3,4-dichlorophe...)
Show SMILES OC(=O)c1ccc(OCCc2c(CCNS(=O)(=O)Cc3ccc(Cl)c(Cl)c3)n(C(c3ccccc3)c3ccccc3)c3ccc(Cl)cc23)cc1
Show InChI InChI=1S/C39H33Cl3N2O5S/c40-30-14-18-36-33(24-30)32(20-22-49-31-15-12-29(13-16-31)39(45)46)37(19-21-43-50(47,48)25-26-11-17-34(41)35(42)23-26)44(36)38(27-7-3-1-4-8-27)28-9-5-2-6-10-28/h1-18,23-24,38,43H,19-22,25H2,(H,45,46)
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n/an/an/a 139n/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Binding affinity to human cPLA2 alpha by isothermal calorimetry


J Med Chem 50: 1380-400 (2007)


Article DOI: 10.1021/jm061131z
BindingDB Entry DOI: 10.7270/Q23F4PB9
More data for this
Ligand-Target Pair
Phospholipase A2


(Homo sapiens (Human))
BDBM50236230
PNG
(2-((R)-4-((3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-dih...)
Show SMILES C[C@H](CCC(=O)NCCS(O)(=O)=O)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
Show InChI InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/t16-,17+,18-,19-,20+,21+,22+,24+,25+,26-/m1/s1
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n/an/an/a 1.00E+4n/an/an/an/an/a



University of Delaware

Curated by ChEMBL


Assay Description
Binding affinity to human pancreatic recombinant 1B PLA2 expressed in Escherichia coli by resonance energy transfer assay in presence of trimethyl-am...


J Nat Prod 72: 24-8 (2009)


Article DOI: 10.1021/np8004453
BindingDB Entry DOI: 10.7270/Q2X34XG0
More data for this
Ligand-Target Pair
Phospholipase A2


(Homo sapiens (Human))
BDBM21680
PNG
((4R)-4-[(1S,2S,5R,7S,9R,10R,11S,14R,15R,16S)-5,9,1...)
Show SMILES C[C@H](CCC(O)=O)[C@H]1CC[C@H]2[C@@H]3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@]12C
Show InChI InChI=1S/C24H40O5/c1-13(4-7-21(28)29)16-5-6-17-22-18(12-20(27)24(16,17)3)23(2)9-8-15(25)10-14(23)11-19(22)26/h13-20,22,25-27H,4-12H2,1-3H3,(H,28,29)/t13-,14+,15-,16-,17+,18+,19-,20+,22+,23+,24-/m1/s1
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n/an/an/a>1.50E+5n/an/an/an/an/a



University of Delaware

Curated by ChEMBL


Assay Description
Binding affinity to human pancreatic recombinant 1B PLA2 expressed in Escherichia coli by resonance energy transfer assay in presence of trimethyl-am...


J Nat Prod 72: 24-8 (2009)


Article DOI: 10.1021/np8004453
BindingDB Entry DOI: 10.7270/Q2X34XG0
More data for this
Ligand-Target Pair
Phospholipase A2, major isoenzyme


(Sus scrofa (pig))
BDBM50139531
PNG
(CHEMBL165545 | Octyl-carbamic acid 3-octylcarbamoy...)
Show SMILES CCCCCCCCNC(=O)Oc1cccc(OC(=O)NCCCCCCCC)c1
Show InChI InChI=1S/C24H40N2O4/c1-3-5-7-9-11-13-18-25-23(27)29-21-16-15-17-22(20-21)30-24(28)26-19-14-12-10-8-6-4-2/h15-17,20H,3-14,18-19H2,1-2H3,(H,25,27)(H,26,28)
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4.00E+3n/an/an/an/an/an/an/an/a



National Chung-Hsing University

Curated by ChEMBL


Assay Description
Binding affinity of the compound against phospholipase A2 of Naja mocambique mocambique


Bioorg Med Chem Lett 14: 751-5 (2004)


Article DOI: 10.1016/j.bmcl.2003.11.047
BindingDB Entry DOI: 10.7270/Q2BK1BRZ
More data for this
Ligand-Target Pair
Phospholipase A2 isozyme CM-I


(Naja mossambica)
BDBM50165906
PNG
(CHEMBL364035 | Hexadecanoic acid 3-octylcarbamoylo...)
Show SMILES CCCCCCCCCCCCCCCC(=O)Oc1cccc(OC(=O)NCCCCCCCC)c1
Show InChI InChI=1S/C31H53NO4/c1-3-5-7-9-11-12-13-14-15-16-17-18-20-25-30(33)35-28-23-22-24-29(27-28)36-31(34)32-26-21-19-10-8-6-4-2/h22-24,27H,3-21,25-26H2,1-2H3,(H,32,34)
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9.60E+3n/an/an/an/an/an/an/an/a



National Chung-Hsing University

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against phospholipase A2


Bioorg Med Chem Lett 15: 2405-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.02.092
BindingDB Entry DOI: 10.7270/Q25X28GT
More data for this
Ligand-Target Pair
Phospholipase A2, major isoenzyme


(Sus scrofa (pig))
BDBM50139529
PNG
(CHEMBL166217 | Octyl-carbamic acid 2-octylcarbamoy...)
Show SMILES CCCCCCCCNC(=O)Oc1ccccc1OC(=O)NCCCCCCCC
Show InChI InChI=1S/C24H40N2O4/c1-3-5-7-9-11-15-19-25-23(27)29-21-17-13-14-18-22(21)30-24(28)26-20-16-12-10-8-6-4-2/h13-14,17-18H,3-12,15-16,19-20H2,1-2H3,(H,25,27)(H,26,28)
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1.10E+4n/an/an/an/an/an/an/an/a



National Chung-Hsing University

Curated by ChEMBL


Assay Description
Binding affinity of the compound against phospholipase A2 of Naja mocambique mocambique


Bioorg Med Chem Lett 14: 751-5 (2004)


Article DOI: 10.1016/j.bmcl.2003.11.047
BindingDB Entry DOI: 10.7270/Q2BK1BRZ
More data for this
Ligand-Target Pair
Phospholipase A2, major isoenzyme


(Sus scrofa (pig))
BDBM50139530
PNG
(CHEMBL434865 | Octyl-carbamic acid 4-octylcarbamoy...)
Show SMILES CCCCCCCCNC(=O)Oc1ccc(OC(=O)NCCCCCCCC)cc1
Show InChI InChI=1S/C24H40N2O4/c1-3-5-7-9-11-13-19-25-23(27)29-21-15-17-22(18-16-21)30-24(28)26-20-14-12-10-8-6-4-2/h15-18H,3-14,19-20H2,1-2H3,(H,25,27)(H,26,28)
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1.50E+4n/an/an/an/an/an/an/an/a



National Chung-Hsing University

Curated by ChEMBL


Assay Description
Binding affinity of the compound against phospholipase A2 of Naja mocambique mocambique


Bioorg Med Chem Lett 14: 751-5 (2004)


Article DOI: 10.1016/j.bmcl.2003.11.047
BindingDB Entry DOI: 10.7270/Q2BK1BRZ
More data for this
Ligand-Target Pair
Phospholipase A2 isozyme CM-I


(Naja mossambica)
BDBM50165905
PNG
(CHEMBL196473 | Octanoic acid 3-octylcarbamoyloxy-p...)
Show SMILES CCCCCCCCNC(=O)Oc1cccc(OC(=O)CCCCCCC)c1
Show InChI InChI=1S/C23H37NO4/c1-3-5-7-9-11-13-18-24-23(26)28-21-16-14-15-20(19-21)27-22(25)17-12-10-8-6-4-2/h14-16,19H,3-13,17-18H2,1-2H3,(H,24,26)
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2.70E+4n/an/an/an/an/an/an/an/a



National Chung-Hsing University

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against phospholipase A2


Bioorg Med Chem Lett 15: 2405-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.02.092
BindingDB Entry DOI: 10.7270/Q25X28GT
More data for this
Ligand-Target Pair
Phospholipase A2 isozyme CM-I


(Naja mossambica)
BDBM50165899
PNG
(CHEMBL196296 | Triphenyl-acetic acid 3-octylcarbam...)
Show SMILES CCCCCCCCNC(=O)Oc1cccc(OC(=O)C(c2ccccc2)(c2ccccc2)c2ccccc2)c1
Show InChI InChI=1S/C35H37NO4/c1-2-3-4-5-6-16-26-36-34(38)40-32-25-17-24-31(27-32)39-33(37)35(28-18-10-7-11-19-28,29-20-12-8-13-21-29)30-22-14-9-15-23-30/h7-15,17-25,27H,2-6,16,26H2,1H3,(H,36,38)
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3.80E+4n/an/an/an/an/an/an/an/a



National Chung-Hsing University

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against phospholipase A2


Bioorg Med Chem Lett 15: 2405-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.02.092
BindingDB Entry DOI: 10.7270/Q25X28GT
More data for this
Ligand-Target Pair
Phospholipase A2 isozyme CM-I


(Naja mossambica)
BDBM50165902
PNG
(2,2-Dimethyl-propionic acid 3-octylcarbamoyloxy-ph...)
Show SMILES CCCCCCCCNC(=O)Oc1cccc(OC(=O)C(C)(C)C)c1
Show InChI InChI=1S/C20H31NO4/c1-5-6-7-8-9-10-14-21-19(23)25-17-13-11-12-16(15-17)24-18(22)20(2,3)4/h11-13,15H,5-10,14H2,1-4H3,(H,21,23)
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5.50E+4n/an/an/an/an/an/an/an/a



National Chung-Hsing University

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against phospholipase A2


Bioorg Med Chem Lett 15: 2405-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.02.092
BindingDB Entry DOI: 10.7270/Q25X28GT
More data for this
Ligand-Target Pair
Phospholipase A2 isozyme CM-I


(Naja mossambica)
BDBM50165900
PNG
(CHEMBL195187 | Phenyl-acetic acid 3-octylcarbamoyl...)
Show SMILES CCCCCCCCNC(=O)Oc1cccc(OC(=O)Cc2ccccc2)c1
Show InChI InChI=1S/C23H29NO4/c1-2-3-4-5-6-10-16-24-23(26)28-21-15-11-14-20(18-21)27-22(25)17-19-12-8-7-9-13-19/h7-9,11-15,18H,2-6,10,16-17H2,1H3,(H,24,26)
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7.30E+4n/an/an/an/an/an/an/an/a



National Chung-Hsing University

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against phospholipase A2


Bioorg Med Chem Lett 15: 2405-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.02.092
BindingDB Entry DOI: 10.7270/Q25X28GT
More data for this
Ligand-Target Pair
Phospholipase A2 isozyme CM-I


(Naja mossambica)
BDBM50165904
PNG
(CHEMBL196716 | Pentanoic acid 3-octylcarbamoyloxy-...)
Show SMILES CCCCCCCCNC(=O)Oc1cccc(OC(=O)CCCC)c1
Show InChI InChI=1S/C20H31NO4/c1-3-5-7-8-9-10-15-21-20(23)25-18-13-11-12-17(16-18)24-19(22)14-6-4-2/h11-13,16H,3-10,14-15H2,1-2H3,(H,21,23)
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7.50E+4n/an/an/an/an/an/an/an/a



National Chung-Hsing University

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against phospholipase A2


Bioorg Med Chem Lett 15: 2405-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.02.092
BindingDB Entry DOI: 10.7270/Q25X28GT
More data for this
Ligand-Target Pair
Phospholipase A2 isozyme CM-I


(Naja mossambica)
BDBM50165907
PNG
(Benzoic acid 3-octylcarbamoyloxy-phenyl ester | CH...)
Show SMILES CCCCCCCCNC(=O)Oc1cccc(OC(=O)c2ccccc2)c1
Show InChI InChI=1S/C22H27NO4/c1-2-3-4-5-6-10-16-23-22(25)27-20-15-11-14-19(17-20)26-21(24)18-12-8-7-9-13-18/h7-9,11-15,17H,2-6,10,16H2,1H3,(H,23,25)
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9.50E+4n/an/an/an/an/an/an/an/a



National Chung-Hsing University

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against phospholipase A2


Bioorg Med Chem Lett 15: 2405-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.02.092
BindingDB Entry DOI: 10.7270/Q25X28GT
More data for this
Ligand-Target Pair
Phospholipase A2 isozyme CM-I


(Naja mossambica)
BDBM50165901
PNG
(Acetic acid 3-octylcarbamoyloxy-phenyl ester | CHE...)
Show SMILES CCCCCCCCNC(=O)Oc1cccc(OC(C)=O)c1
Show InChI InChI=1S/C17H25NO4/c1-3-4-5-6-7-8-12-18-17(20)22-16-11-9-10-15(13-16)21-14(2)19/h9-11,13H,3-8,12H2,1-2H3,(H,18,20)
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9.80E+4n/an/an/an/an/an/an/an/a



National Chung-Hsing University

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against phospholipase A2


Bioorg Med Chem Lett 15: 2405-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.02.092
BindingDB Entry DOI: 10.7270/Q25X28GT
More data for this
Ligand-Target Pair
Phospholipase A2 isozyme CM-I


(Naja mossambica)
BDBM50165903
PNG
(CHEMBL373175 | Trichloro-acetic acid 3-octylcarbam...)
Show SMILES CCCCCCCCNC(=O)Oc1cccc(OC(=O)C(Cl)(Cl)Cl)c1
Show InChI InChI=1S/C17H22Cl3NO4/c1-2-3-4-5-6-7-11-21-16(23)25-14-10-8-9-13(12-14)24-15(22)17(18,19)20/h8-10,12H,2-7,11H2,1H3,(H,21,23)
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1.20E+5n/an/an/an/an/an/an/an/a



National Chung-Hsing University

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against phospholipase A2


Bioorg Med Chem Lett 15: 2405-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.02.092
BindingDB Entry DOI: 10.7270/Q25X28GT
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM23738
PNG
(2-(1-benzyl-5-methoxy-2-methyl-1H-indol-3-yl)aceta...)
Show SMILES COc1ccc2n(Cc3ccccc3)c(C)c(CC(N)=O)c2c1
Show InChI InChI=1S/C19H20N2O2/c1-13-16(11-19(20)22)17-10-15(23-2)8-9-18(17)21(13)12-14-6-4-3-5-7-14/h3-10H,11-12H2,1-2H3,(H2,20,22)
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n/an/a 540n/an/an/an/a8.022



Peking University



Assay Description
Phospholipase A2 was assayed using unlabeled lipids as substrate and 1-anilinonaphthalene-8-sulfonate (ANS) as a probe for the interfacial reaction. ...


J Med Chem 51: 3360-6 (2008)


Article DOI: 10.1021/jm7010707
BindingDB Entry DOI: 10.7270/Q2P26WFC
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM23740
PNG
(2-(5-methoxy-2-methyl-1-{[2-(pentyloxy)phenyl]meth...)
Show SMILES CCCCCOc1ccccc1Cn1c(C)c(CC(N)=O)c2cc(OC)ccc12
Show InChI InChI=1S/C24H30N2O3/c1-4-5-8-13-29-23-10-7-6-9-18(23)16-26-17(2)20(15-24(25)27)21-14-19(28-3)11-12-22(21)26/h6-7,9-12,14H,4-5,8,13,15-16H2,1-3H3,(H2,25,27)
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n/an/a 120n/an/an/an/a8.022



Peking University



Assay Description
Phospholipase A2 was assayed using unlabeled lipids as substrate and 1-anilinonaphthalene-8-sulfonate (ANS) as a probe for the interfacial reaction. ...


J Med Chem 51: 3360-6 (2008)


Article DOI: 10.1021/jm7010707
BindingDB Entry DOI: 10.7270/Q2P26WFC
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM23741
PNG
(2-[1-({2-[3-(2-{[3-(carbamoylmethyl)-5-methoxy-2-m...)
Show SMILES COc1ccc2n(Cc3ccccc3OCCCOc3ccccc3Cn3c(C)c(CC(N)=O)c4cc(OC)ccc34)c(C)c(CC(N)=O)c2c1
Show InChI InChI=1S/C41H44N4O6/c1-26-32(22-40(42)46)34-20-30(48-3)14-16-36(34)44(26)24-28-10-5-7-12-38(28)50-18-9-19-51-39-13-8-6-11-29(39)25-45-27(2)33(23-41(43)47)35-21-31(49-4)15-17-37(35)45/h5-8,10-17,20-21H,9,18-19,22-25H2,1-4H3,(H2,42,46)(H2,43,47)
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n/an/a 48n/an/an/an/a8.022



Peking University



Assay Description
Phospholipase A2 was assayed using unlabeled lipids as substrate and 1-anilinonaphthalene-8-sulfonate (ANS) as a probe for the interfacial reaction. ...


J Med Chem 51: 3360-6 (2008)


Article DOI: 10.1021/jm7010707
BindingDB Entry DOI: 10.7270/Q2P26WFC
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM23742
PNG
(2-[1-({2-[4-(2-{[3-(carbamoylmethyl)-5-methoxy-2-m...)
Show SMILES COc1ccc2n(Cc3ccccc3OCCCCOc3ccccc3Cn3c(C)c(CC(N)=O)c4cc(OC)ccc34)c(C)c(CC(N)=O)c2c1
Show InChI InChI=1S/C42H46N4O6/c1-27-33(23-41(43)47)35-21-31(49-3)15-17-37(35)45(27)25-29-11-5-7-13-39(29)51-19-9-10-20-52-40-14-8-6-12-30(40)26-46-28(2)34(24-42(44)48)36-22-32(50-4)16-18-38(36)46/h5-8,11-18,21-22H,9-10,19-20,23-26H2,1-4H3,(H2,43,47)(H2,44,48)
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n/an/a 60n/an/an/an/a8.022



Peking University



Assay Description
Phospholipase A2 was assayed using unlabeled lipids as substrate and 1-anilinonaphthalene-8-sulfonate (ANS) as a probe for the interfacial reaction. ...


J Med Chem 51: 3360-6 (2008)


Article DOI: 10.1021/jm7010707
BindingDB Entry DOI: 10.7270/Q2P26WFC
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM23743
PNG
(2-{1-[(2-{[5-(2-{[3-(carbamoylmethyl)-5-methoxy-2-...)
Show SMILES COc1ccc2n(Cc3ccccc3OCCCCCOc3ccccc3Cn3c(C)c(CC(N)=O)c4cc(OC)ccc34)c(C)c(CC(N)=O)c2c1
Show InChI InChI=1S/C43H48N4O6/c1-28-34(24-42(44)48)36-22-32(50-3)16-18-38(36)46(28)26-30-12-6-8-14-40(30)52-20-10-5-11-21-53-41-15-9-7-13-31(41)27-47-29(2)35(25-43(45)49)37-23-33(51-4)17-19-39(37)47/h6-9,12-19,22-23H,5,10-11,20-21,24-27H2,1-4H3,(H2,44,48)(H2,45,49)
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n/an/a 24n/an/an/an/a8.022



Peking University



Assay Description
Phospholipase A2 was assayed using unlabeled lipids as substrate and 1-anilinonaphthalene-8-sulfonate (ANS) as a probe for the interfacial reaction. ...


J Med Chem 51: 3360-6 (2008)


Article DOI: 10.1021/jm7010707
BindingDB Entry DOI: 10.7270/Q2P26WFC
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM23744
PNG
(2-{1-[(2-{[6-(2-{[3-(carbamoylmethyl)-5-methoxy-2-...)
Show SMILES COc1ccc2n(Cc3ccccc3OCCCCCCOc3ccccc3Cn3c(C)c(CC(N)=O)c4cc(OC)ccc34)c(C)c(CC(N)=O)c2c1
Show InChI InChI=1S/C44H50N4O6/c1-29-35(25-43(45)49)37-23-33(51-3)17-19-39(37)47(29)27-31-13-7-9-15-41(31)53-21-11-5-6-12-22-54-42-16-10-8-14-32(42)28-48-30(2)36(26-44(46)50)38-24-34(52-4)18-20-40(38)48/h7-10,13-20,23-24H,5-6,11-12,21-22,25-28H2,1-4H3,(H2,45,49)(H2,46,50)
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n/an/a 39n/an/an/an/a8.022



Peking University



Assay Description
Phospholipase A2 was assayed using unlabeled lipids as substrate and 1-anilinonaphthalene-8-sulfonate (ANS) as a probe for the interfacial reaction. ...


J Med Chem 51: 3360-6 (2008)


Article DOI: 10.1021/jm7010707
BindingDB Entry DOI: 10.7270/Q2P26WFC
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM23745
PNG
(2-{1-[(2-{[7-(2-{[3-(carbamoylmethyl)-5-methoxy-2-...)
Show SMILES COc1ccc2n(Cc3ccccc3OCCCCCCCOc3ccccc3Cn3c(C)c(CC(N)=O)c4cc(OC)ccc34)c(C)c(CC(N)=O)c2c1
Show InChI InChI=1S/C45H52N4O6/c1-30-36(26-44(46)50)38-24-34(52-3)18-20-40(38)48(30)28-32-14-8-10-16-42(32)54-22-12-6-5-7-13-23-55-43-17-11-9-15-33(43)29-49-31(2)37(27-45(47)51)39-25-35(53-4)19-21-41(39)49/h8-11,14-21,24-25H,5-7,12-13,22-23,26-29H2,1-4H3,(H2,46,50)(H2,47,51)
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n/an/a 52n/an/an/an/a8.022



Peking University



Assay Description
Phospholipase A2 was assayed using unlabeled lipids as substrate and 1-anilinonaphthalene-8-sulfonate (ANS) as a probe for the interfacial reaction. ...


J Med Chem 51: 3360-6 (2008)


Article DOI: 10.1021/jm7010707
BindingDB Entry DOI: 10.7270/Q2P26WFC
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM23746
PNG
(2-{1-[(2-{[8-(2-{[3-(carbamoylmethyl)-5-methoxy-2-...)
Show SMILES COc1ccc2n(Cc3ccccc3OCCCCCCCCOc3ccccc3Cn3c(C)c(CC(N)=O)c4cc(OC)ccc34)c(C)c(CC(N)=O)c2c1
Show InChI InChI=1S/C46H54N4O6/c1-31-37(27-45(47)51)39-25-35(53-3)19-21-41(39)49(31)29-33-15-9-11-17-43(33)55-23-13-7-5-6-8-14-24-56-44-18-12-10-16-34(44)30-50-32(2)38(28-46(48)52)40-26-36(54-4)20-22-42(40)50/h9-12,15-22,25-26H,5-8,13-14,23-24,27-30H2,1-4H3,(H2,47,51)(H2,48,52)
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n/an/a 58n/an/an/an/a8.022



Peking University



Assay Description
Phospholipase A2 was assayed using unlabeled lipids as substrate and 1-anilinonaphthalene-8-sulfonate (ANS) as a probe for the interfacial reaction. ...


J Med Chem 51: 3360-6 (2008)


Article DOI: 10.1021/jm7010707
BindingDB Entry DOI: 10.7270/Q2P26WFC
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM23747
PNG
(Bis-indole Derivative, 9)
Show SMILES COc1ccc2n(Cc3ccccc3OCCCCCCCCCOc3ccccc3Cn3c(C)c(CC(N)=O)c4cc(OC)ccc34)c(C)c(CC(N)=O)c2c1
Show InChI InChI=1S/C47H56N4O6/c1-32-38(28-46(48)52)40-26-36(54-3)20-22-42(40)50(32)30-34-16-10-12-18-44(34)56-24-14-8-6-5-7-9-15-25-57-45-19-13-11-17-35(45)31-51-33(2)39(29-47(49)53)41-27-37(55-4)21-23-43(41)51/h10-13,16-23,26-27H,5-9,14-15,24-25,28-31H2,1-4H3,(H2,48,52)(H2,49,53)
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n/an/a 49n/an/an/an/a8.022



Peking University



Assay Description
Phospholipase A2 was assayed using unlabeled lipids as substrate and 1-anilinonaphthalene-8-sulfonate (ANS) as a probe for the interfacial reaction. ...


J Med Chem 51: 3360-6 (2008)


Article DOI: 10.1021/jm7010707
BindingDB Entry DOI: 10.7270/Q2P26WFC
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM23748
PNG
(Bis-indole Derivative, 10)
Show SMILES COc1ccc2n(Cc3cccc(OCCCCCOc4cccc(Cn5c(C)c(CC(N)=O)c6cc(OC)ccc56)c4)c3)c(C)c(CC(N)=O)c2c1
Show InChI InChI=1S/C43H48N4O6/c1-28-36(24-42(44)48)38-22-32(50-3)14-16-40(38)46(28)26-30-10-8-12-34(20-30)52-18-6-5-7-19-53-35-13-9-11-31(21-35)27-47-29(2)37(25-43(45)49)39-23-33(51-4)15-17-41(39)47/h8-17,20-23H,5-7,18-19,24-27H2,1-4H3,(H2,44,48)(H2,45,49)
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n/an/a 76n/an/an/an/a8.022



Peking University



Assay Description
Phospholipase A2 was assayed using unlabeled lipids as substrate and 1-anilinonaphthalene-8-sulfonate (ANS) as a probe for the interfacial reaction. ...


J Med Chem 51: 3360-6 (2008)


Article DOI: 10.1021/jm7010707
BindingDB Entry DOI: 10.7270/Q2P26WFC
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM23749
PNG
(Bis-indole Derivative, 11)
Show SMILES COc1ccc2n(Cc3ccc(OCCCCCOc4ccc(Cn5c(C)c(CC(N)=O)c6cc(OC)ccc56)cc4)cc3)c(C)c(CC(N)=O)c2c1
Show InChI InChI=1S/C43H48N4O6/c1-28-36(24-42(44)48)38-22-34(50-3)16-18-40(38)46(28)26-30-8-12-32(13-9-30)52-20-6-5-7-21-53-33-14-10-31(11-15-33)27-47-29(2)37(25-43(45)49)39-23-35(51-4)17-19-41(39)47/h8-19,22-23H,5-7,20-21,24-27H2,1-4H3,(H2,44,48)(H2,45,49)
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n/an/a 86n/an/an/an/a8.022



Peking University



Assay Description
Phospholipase A2 was assayed using unlabeled lipids as substrate and 1-anilinonaphthalene-8-sulfonate (ANS) as a probe for the interfacial reaction. ...


J Med Chem 51: 3360-6 (2008)


Article DOI: 10.1021/jm7010707
BindingDB Entry DOI: 10.7270/Q2P26WFC
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM23750
PNG
(3-{4-[(4-tetradecylpiperazin-1-yl)methyl]phenyl}-4...)
Show SMILES CCCCCCCCCCCCCCN1CCN(Cc2ccc(cc2)-c2nc(=O)o[nH]2)CC1
Show InChI InChI=1S/C27H44N4O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-18-30-19-21-31(22-20-30)23-24-14-16-25(17-15-24)26-28-27(32)33-29-26/h14-17H,2-13,18-23H2,1H3,(H,28,29,32)
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n/an/a>1.00E+5n/an/an/an/a7.522



Universite Paris 7-Denis Diderot



Assay Description
PLA2 activity is by using the fluorescent phospholipid analogue, beta-pyC-10-PG as the substrate. The increase in fluorescence (ex @342 nm and em@388...


Bioorg Med Chem 16: 1242-53 (2008)


Article DOI: 10.1016/j.bmc.2007.10.077
BindingDB Entry DOI: 10.7270/Q2J964PK
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM23752
PNG
(3-{4-[(4-hexadecylpiperazin-1-yl)methyl]phenyl}-4,...)
Show SMILES CCCCCCCCCCCCCCCCN1CCN(Cc2ccc(cc2)-c2nc(=O)o[nH]2)CC1
Show InChI InChI=1S/C29H48N4O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-20-32-21-23-33(24-22-32)25-26-16-18-27(19-17-26)28-30-29(34)35-31-28/h16-19H,2-15,20-25H2,1H3,(H,30,31,34)
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n/an/a>1.00E+5n/an/an/an/a7.522



Universite Paris 7-Denis Diderot



Assay Description
PLA2 activity is by using the fluorescent phospholipid analogue, beta-pyC-10-PG as the substrate. The increase in fluorescence (ex @342 nm and em@388...


Bioorg Med Chem 16: 1242-53 (2008)


Article DOI: 10.1016/j.bmc.2007.10.077
BindingDB Entry DOI: 10.7270/Q2J964PK
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM23753
PNG
(3-{4-[(4-octadecylpiperazin-1-yl)methyl]phenyl}-4,...)
Show SMILES CCCCCCCCCCCCCCCCCCN1CCN(Cc2ccc(cc2)-c2nc(=O)o[nH]2)CC1
Show InChI InChI=1S/C31H52N4O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-22-34-23-25-35(26-24-34)27-28-18-20-29(21-19-28)30-32-31(36)37-33-30/h18-21H,2-17,22-27H2,1H3,(H,32,33,36)
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n/an/a 5.08E+3n/an/an/an/a7.522



Universite Paris 7-Denis Diderot



Assay Description
PLA2 activity is by using the fluorescent phospholipid analogue, beta-pyC-10-PG as the substrate. The increase in fluorescence (ex @342 nm and em@388...


Bioorg Med Chem 16: 1242-53 (2008)


Article DOI: 10.1016/j.bmc.2007.10.077
BindingDB Entry DOI: 10.7270/Q2J964PK
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM23754
PNG
(3-({4-[(4-tetradecylpiperazin-1-yl)methyl]phenyl}m...)
Show SMILES CCCCCCCCCCCCCCN1CCN(Cc2ccc(Cc3nc(=O)o[nH]3)cc2)CC1
Show InChI InChI=1S/C28H46N4O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-18-31-19-21-32(22-20-31)24-26-16-14-25(15-17-26)23-27-29-28(33)34-30-27/h14-17H,2-13,18-24H2,1H3,(H,29,30,33)
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n/an/a>1.00E+4n/an/an/an/a7.522



Universite Paris 7-Denis Diderot



Assay Description
PLA2 activity is by using the fluorescent phospholipid analogue, beta-pyC-10-PG as the substrate. The increase in fluorescence (ex @342 nm and em@388...


Bioorg Med Chem 16: 1242-53 (2008)


Article DOI: 10.1016/j.bmc.2007.10.077
BindingDB Entry DOI: 10.7270/Q2J964PK
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM23755
PNG
(3-({4-[(4-hexadecylpiperazin-1-yl)methyl]phenyl}me...)
Show SMILES CCCCCCCCCCCCCCCCN1CCN(Cc2ccc(Cc3nc(=O)o[nH]3)cc2)CC1
Show InChI InChI=1S/C30H50N4O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-20-33-21-23-34(24-22-33)26-28-18-16-27(17-19-28)25-29-31-30(35)36-32-29/h16-19H,2-15,20-26H2,1H3,(H,31,32,35)
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n/an/a 1.00E+4n/an/an/an/a7.522



Universite Paris 7-Denis Diderot



Assay Description
PLA2 activity is by using the fluorescent phospholipid analogue, beta-pyC-10-PG as the substrate. The increase in fluorescence (ex @342 nm and em@388...


Bioorg Med Chem 16: 1242-53 (2008)


Article DOI: 10.1016/j.bmc.2007.10.077
BindingDB Entry DOI: 10.7270/Q2J964PK
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM23756
PNG
(3-({4-[(4-octadecylpiperazin-1-yl)methyl]phenyl}me...)
Show SMILES CCCCCCCCCCCCCCCCCCN1CCN(Cc2ccc(Cc3nc(=O)o[nH]3)cc2)CC1
Show InChI InChI=1S/C32H54N4O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-22-35-23-25-36(26-24-35)28-30-20-18-29(19-21-30)27-31-33-32(37)38-34-31/h18-21H,2-17,22-28H2,1H3,(H,33,34,37)
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n/an/a 2.20E+3n/an/an/an/a7.522



Universite Paris 7-Denis Diderot



Assay Description
PLA2 activity is by using the fluorescent phospholipid analogue, beta-pyC-10-PG as the substrate. The increase in fluorescence (ex @342 nm and em@388...


Bioorg Med Chem 16: 1242-53 (2008)


Article DOI: 10.1016/j.bmc.2007.10.077
BindingDB Entry DOI: 10.7270/Q2J964PK
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM23757
PNG
(3-{4-[(4-tetradecylpiperazin-1-yl)carbonyl]phenyl}...)
Show SMILES CCCCCCCCCCCCCCN1CCN(CC1)C(=O)c1ccc(cc1)-c1nc(=O)o[nH]1
Show InChI InChI=1S/C27H42N4O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-18-30-19-21-31(22-20-30)26(32)24-16-14-23(15-17-24)25-28-27(33)34-29-25/h14-17H,2-13,18-22H2,1H3,(H,28,29,33)
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n/an/a>1.00E+5n/an/an/an/a7.522



Universite Paris 7-Denis Diderot



Assay Description
PLA2 activity is by using the fluorescent phospholipid analogue, beta-pyC-10-PG as the substrate. The increase in fluorescence (ex @342 nm and em@388...


Bioorg Med Chem 16: 1242-53 (2008)


Article DOI: 10.1016/j.bmc.2007.10.077
BindingDB Entry DOI: 10.7270/Q2J964PK
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM23758
PNG
(3-{4-[(4-hexadecylpiperazin-1-yl)carbonyl]phenyl}-...)
Show SMILES CCCCCCCCCCCCCCCCN1CCN(CC1)C(=O)c1ccc(cc1)-c1nc(=O)o[nH]1
Show InChI InChI=1S/C29H46N4O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-20-32-21-23-33(24-22-32)28(34)26-18-16-25(17-19-26)27-30-29(35)36-31-27/h16-19H,2-15,20-24H2,1H3,(H,30,31,35)
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n/an/a>1.00E+5n/an/an/an/a7.522



Universite Paris 7-Denis Diderot



Assay Description
PLA2 activity is by using the fluorescent phospholipid analogue, beta-pyC-10-PG as the substrate. The increase in fluorescence (ex @342 nm and em@388...


Bioorg Med Chem 16: 1242-53 (2008)


Article DOI: 10.1016/j.bmc.2007.10.077
BindingDB Entry DOI: 10.7270/Q2J964PK
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM23759
PNG
(3-{4-[(4-octadecylpiperazin-1-yl)carbonyl]phenyl}-...)
Show SMILES CCCCCCCCCCCCCCCCCCN1CCN(CC1)C(=O)c1ccc(cc1)-c1nc(=O)o[nH]1
Show InChI InChI=1S/C31H50N4O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-22-34-23-25-35(26-24-34)30(36)28-20-18-27(19-21-28)29-32-31(37)38-33-29/h18-21H,2-17,22-26H2,1H3,(H,32,33,37)
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n/an/a 1.10E+3n/an/an/an/a7.522



Universite Paris 7-Denis Diderot



Assay Description
PLA2 activity is by using the fluorescent phospholipid analogue, beta-pyC-10-PG as the substrate. The increase in fluorescence (ex @342 nm and em@388...


Bioorg Med Chem 16: 1242-53 (2008)


Article DOI: 10.1016/j.bmc.2007.10.077
BindingDB Entry DOI: 10.7270/Q2J964PK
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM23760
PNG
(3-({4-[(4-tetradecylpiperazin-1-yl)carbonyl]phenyl...)
Show SMILES CCCCCCCCCCCCCCN1CCN(CC1)C(=O)c1ccc(Cc2nc(=O)o[nH]2)cc1
Show InChI InChI=1S/C28H44N4O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-18-31-19-21-32(22-20-31)27(33)25-16-14-24(15-17-25)23-26-29-28(34)35-30-26/h14-17H,2-13,18-23H2,1H3,(H,29,30,34)
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n/an/a 9.00E+3n/an/an/an/a7.522



Universite Paris 7-Denis Diderot



Assay Description
PLA2 activity is by using the fluorescent phospholipid analogue, beta-pyC-10-PG as the substrate. The increase in fluorescence (ex @342 nm and em@388...


Bioorg Med Chem 16: 1242-53 (2008)


Article DOI: 10.1016/j.bmc.2007.10.077
BindingDB Entry DOI: 10.7270/Q2J964PK
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM23761
PNG
(3-({4-[(4-hexadecylpiperazin-1-yl)carbonyl]phenyl}...)
Show SMILES CCCCCCCCCCCCCCCCN1CCN(CC1)C(=O)c1ccc(Cc2nc(=O)o[nH]2)cc1
Show InChI InChI=1S/C30H48N4O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-20-33-21-23-34(24-22-33)29(35)27-18-16-26(17-19-27)25-28-31-30(36)37-32-28/h16-19H,2-15,20-25H2,1H3,(H,31,32,36)
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n/an/a 4.00E+3n/an/an/an/a7.522



Universite Paris 7-Denis Diderot



Assay Description
PLA2 activity is by using the fluorescent phospholipid analogue, beta-pyC-10-PG as the substrate. The increase in fluorescence (ex @342 nm and em@388...


Bioorg Med Chem 16: 1242-53 (2008)


Article DOI: 10.1016/j.bmc.2007.10.077
BindingDB Entry DOI: 10.7270/Q2J964PK
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM23762
PNG
(3-({4-[(4-octadecylpiperazin-1-yl)carbonyl]phenyl}...)
Show SMILES CCCCCCCCCCCCCCCCCCN1CCN(CC1)C(=O)c1ccc(Cc2nc(=O)o[nH]2)cc1
Show InChI InChI=1S/C32H52N4O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-22-35-23-25-36(26-24-35)31(37)29-20-18-28(19-21-29)27-30-33-32(38)39-34-30/h18-21H,2-17,22-27H2,1H3,(H,33,34,38)
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n/an/a 800n/an/an/an/a7.522



Universite Paris 7-Denis Diderot



Assay Description
PLA2 activity is by using the fluorescent phospholipid analogue, beta-pyC-10-PG as the substrate. The increase in fluorescence (ex @342 nm and em@388...


Bioorg Med Chem 16: 1242-53 (2008)


Article DOI: 10.1016/j.bmc.2007.10.077
BindingDB Entry DOI: 10.7270/Q2J964PK
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM23763
PNG
(3-({4-[(4-icosylpiperazin-1-yl)carbonyl]phenyl}met...)
Show SMILES CCCCCCCCCCCCCCCCCCCCN1CCN(CC1)C(=O)c1ccc(Cc2nc(=O)o[nH]2)cc1
Show InChI InChI=1S/C34H56N4O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-24-37-25-27-38(28-26-37)33(39)31-22-20-30(21-23-31)29-32-35-34(40)41-36-32/h20-23H,2-19,24-29H2,1H3,(H,35,36,40)
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n/an/a 100n/an/an/an/a7.522



Universite Paris 7-Denis Diderot



Assay Description
PLA2 activity is by using the fluorescent phospholipid analogue, beta-pyC-10-PG as the substrate. The increase in fluorescence (ex @342 nm and em@388...


Bioorg Med Chem 16: 1242-53 (2008)


Article DOI: 10.1016/j.bmc.2007.10.077
BindingDB Entry DOI: 10.7270/Q2J964PK
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM23764
PNG
(3-({4-[(4-docosylpiperazin-1-yl)carbonyl]phenyl}me...)
Show SMILES CCCCCCCCCCCCCCCCCCCCCCN1CCN(CC1)C(=O)c1ccc(Cc2nc(=O)o[nH]2)cc1
Show InChI InChI=1S/C36H60N4O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-26-39-27-29-40(30-28-39)35(41)33-24-22-32(23-25-33)31-34-37-36(42)43-38-34/h22-25H,2-21,26-31H2,1H3,(H,37,38,42)
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n/an/a 100n/an/an/an/a7.522



Universite Paris 7-Denis Diderot



Assay Description
PLA2 activity is by using the fluorescent phospholipid analogue, beta-pyC-10-PG as the substrate. The increase in fluorescence (ex @342 nm and em@388...


Bioorg Med Chem 16: 1242-53 (2008)


Article DOI: 10.1016/j.bmc.2007.10.077
BindingDB Entry DOI: 10.7270/Q2J964PK
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM23765
PNG
(3-{[4-(4-tetradecylpiperazin-1-yl)phenyl]methyl}-4...)
Show SMILES CCCCCCCCCCCCCCN1CCN(CC1)c1ccc(Cc2nc(=O)o[nH]2)cc1
Show InChI InChI=1S/C27H44N4O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-18-30-19-21-31(22-20-30)25-16-14-24(15-17-25)23-26-28-27(32)33-29-26/h14-17H,2-13,18-23H2,1H3,(H,28,29,32)
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n/an/a 4.50E+3n/an/an/an/a7.522



Universite Paris 7-Denis Diderot



Assay Description
PLA2 activity is by using the fluorescent phospholipid analogue, beta-pyC-10-PG as the substrate. The increase in fluorescence (ex @342 nm and em@388...


Bioorg Med Chem 16: 1242-53 (2008)


Article DOI: 10.1016/j.bmc.2007.10.077
BindingDB Entry DOI: 10.7270/Q2J964PK
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM23766
PNG
(3-{[4-(4-hexadecylpiperazin-1-yl)phenyl]methyl}-4,...)
Show SMILES CCCCCCCCCCCCCCCCN1CCN(CC1)c1ccc(Cc2nc(=O)o[nH]2)cc1
Show InChI InChI=1S/C29H48N4O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-20-32-21-23-33(24-22-32)27-18-16-26(17-19-27)25-28-30-29(34)35-31-28/h16-19H,2-15,20-25H2,1H3,(H,30,31,34)
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n/an/a 3.50E+3n/an/an/an/a7.522



Universite Paris 7-Denis Diderot



Assay Description
PLA2 activity is by using the fluorescent phospholipid analogue, beta-pyC-10-PG as the substrate. The increase in fluorescence (ex @342 nm and em@388...


Bioorg Med Chem 16: 1242-53 (2008)


Article DOI: 10.1016/j.bmc.2007.10.077
BindingDB Entry DOI: 10.7270/Q2J964PK
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM23767
PNG
(3-{[4-(4-octadecylpiperazin-1-yl)phenyl]methyl}-4,...)
Show SMILES CCCCCCCCCCCCCCCCCCN1CCN(CC1)c1ccc(Cc2nc(=O)o[nH]2)cc1
Show InChI InChI=1S/C31H52N4O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-22-34-23-25-35(26-24-34)29-20-18-28(19-21-29)27-30-32-31(36)37-33-30/h18-21H,2-17,22-27H2,1H3,(H,32,33,36)
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n/an/a 2.71E+3n/an/an/an/a7.522



Universite Paris 7-Denis Diderot



Assay Description
PLA2 activity is by using the fluorescent phospholipid analogue, beta-pyC-10-PG as the substrate. The increase in fluorescence (ex @342 nm and em@388...


Bioorg Med Chem 16: 1242-53 (2008)


Article DOI: 10.1016/j.bmc.2007.10.077
BindingDB Entry DOI: 10.7270/Q2J964PK
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM23768
PNG
(3-(2-{4-[(4-tetradecylpiperazin-1-yl)carbonyl]phen...)
Show SMILES CCCCCCCCCCCCCCN1CCN(CC1)C(=O)c1ccc(CCc2nc(=O)o[nH]2)cc1
Show InChI InChI=1S/C29H46N4O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-20-32-21-23-33(24-22-32)28(34)26-17-14-25(15-18-26)16-19-27-30-29(35)36-31-27/h14-15,17-18H,2-13,16,19-24H2,1H3,(H,30,31,35)
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n/an/a 1.87E+4n/an/an/an/a7.522



Universite Paris 7-Denis Diderot



Assay Description
PLA2 activity is by using the fluorescent phospholipid analogue, beta-pyC-10-PG as the substrate. The increase in fluorescence (ex @342 nm and em@388...


Bioorg Med Chem 16: 1242-53 (2008)


Article DOI: 10.1016/j.bmc.2007.10.077
BindingDB Entry DOI: 10.7270/Q2J964PK
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM23769
PNG
(3-(3-{4-[(4-tetradecylpiperazin-1-yl)carbonyl]phen...)
Show SMILES CCCCCCCCCCCCCCN1CCN(CC1)C(=O)c1ccc(CCCc2nc(=O)o[nH]2)cc1
Show InChI InChI=1S/C30H48N4O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-21-33-22-24-34(25-23-33)29(35)27-19-17-26(18-20-27)15-14-16-28-31-30(36)37-32-28/h17-20H,2-16,21-25H2,1H3,(H,31,32,36)
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n/an/a 5.30E+3n/an/an/an/a7.522



Universite Paris 7-Denis Diderot



Assay Description
PLA2 activity is by using the fluorescent phospholipid analogue, beta-pyC-10-PG as the substrate. The increase in fluorescence (ex @342 nm and em@388...


Bioorg Med Chem 16: 1242-53 (2008)


Article DOI: 10.1016/j.bmc.2007.10.077
BindingDB Entry DOI: 10.7270/Q2J964PK
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM23770
PNG
(3-{[4-(tetradecyloxy)phenyl]methyl}-4,5-dihydro-1,...)
Show SMILES CCCCCCCCCCCCCCOc1ccc(Cc2nc(=O)o[nH]2)cc1
Show InChI InChI=1S/C23H36N2O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-18-27-21-16-14-20(15-17-21)19-22-24-23(26)28-25-22/h14-17H,2-13,18-19H2,1H3,(H,24,25,26)
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n/an/a 4.00E+3n/an/an/an/a7.522



Universite Paris 7-Denis Diderot



Assay Description
PLA2 activity is by using the fluorescent phospholipid analogue, beta-pyC-10-PG as the substrate. The increase in fluorescence (ex @342 nm and em@388...


Bioorg Med Chem 16: 1242-53 (2008)


Article DOI: 10.1016/j.bmc.2007.10.077
BindingDB Entry DOI: 10.7270/Q2J964PK
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM23771
PNG
((3-{[1-benzyl-3-(carbamoylmethyl)-2-ethyl-1H-indol...)
Show SMILES CCc1c(CC(N)=O)c2cc(OCCCP(O)(O)=O)ccc2n1Cc1ccccc1
Show InChI InChI=1S/C22H27N2O5P/c1-2-20-19(14-22(23)25)18-13-17(29-11-6-12-30(26,27)28)9-10-21(18)24(20)15-16-7-4-3-5-8-16/h3-5,7-10,13H,2,6,11-12,14-15H2,1H3,(H2,23,25)(H2,26,27,28)
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n/an/a 470n/an/an/an/a7.522



Universite Paris 7-Denis Diderot



Assay Description
PLA2 activity is by using the fluorescent phospholipid analogue, beta-pyC-10-PG as the substrate. The increase in fluorescence (ex @342 nm and em@388...


Bioorg Med Chem 16: 1242-53 (2008)


Article DOI: 10.1016/j.bmc.2007.10.077
BindingDB Entry DOI: 10.7270/Q2J964PK
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Phospholipase A2, major isoenzyme


(Sus scrofa (pig))
BDBM23750
PNG
(3-{4-[(4-tetradecylpiperazin-1-yl)methyl]phenyl}-4...)
Show SMILES CCCCCCCCCCCCCCN1CCN(Cc2ccc(cc2)-c2nc(=O)o[nH]2)CC1
Show InChI InChI=1S/C27H44N4O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-18-30-19-21-31(22-20-30)23-24-14-16-25(17-15-24)26-28-27(32)33-29-26/h14-17H,2-13,18-23H2,1H3,(H,28,29,32)
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n/an/a>1.00E+5n/an/an/an/a7.522



Universite Paris 7-Denis Diderot



Assay Description
PLA2 activity is by using the fluorescent phospholipid analogue, beta-pyC-10-PG as the substrate. The increase in fluorescence (ex @342 nm and em@388...


Bioorg Med Chem 16: 1242-53 (2008)


Article DOI: 10.1016/j.bmc.2007.10.077
BindingDB Entry DOI: 10.7270/Q2J964PK
More data for this
Ligand-Target Pair
Phospholipase A2, major isoenzyme


(Sus scrofa (pig))
BDBM23752
PNG
(3-{4-[(4-hexadecylpiperazin-1-yl)methyl]phenyl}-4,...)
Show SMILES CCCCCCCCCCCCCCCCN1CCN(Cc2ccc(cc2)-c2nc(=O)o[nH]2)CC1
Show InChI InChI=1S/C29H48N4O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-20-32-21-23-33(24-22-32)25-26-16-18-27(19-17-26)28-30-29(34)35-31-28/h16-19H,2-15,20-25H2,1H3,(H,30,31,34)
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n/an/a>1.00E+5n/an/an/an/a7.522



Universite Paris 7-Denis Diderot



Assay Description
PLA2 activity is by using the fluorescent phospholipid analogue, beta-pyC-10-PG as the substrate. The increase in fluorescence (ex @342 nm and em@388...


Bioorg Med Chem 16: 1242-53 (2008)


Article DOI: 10.1016/j.bmc.2007.10.077
BindingDB Entry DOI: 10.7270/Q2J964PK
More data for this
Ligand-Target Pair
Phospholipase A2, major isoenzyme


(Sus scrofa (pig))
BDBM23753
PNG
(3-{4-[(4-octadecylpiperazin-1-yl)methyl]phenyl}-4,...)
Show SMILES CCCCCCCCCCCCCCCCCCN1CCN(Cc2ccc(cc2)-c2nc(=O)o[nH]2)CC1
Show InChI InChI=1S/C31H52N4O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-22-34-23-25-35(26-24-34)27-28-18-20-29(21-19-28)30-32-31(36)37-33-30/h18-21H,2-17,22-27H2,1H3,(H,32,33,36)
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n/an/a>1.00E+5n/an/an/an/a7.522



Universite Paris 7-Denis Diderot



Assay Description
PLA2 activity is by using the fluorescent phospholipid analogue, beta-pyC-10-PG as the substrate. The increase in fluorescence (ex @342 nm and em@388...


Bioorg Med Chem 16: 1242-53 (2008)


Article DOI: 10.1016/j.bmc.2007.10.077
BindingDB Entry DOI: 10.7270/Q2J964PK
More data for this
Ligand-Target Pair
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