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Compile Data Set for Download or QSAR

Found 66 hits Enz. Inhib. hit(s) with Target = 'Placenta growth factor'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Placenta growth factor


(Homo sapiens)
BDBM50339212
PNG
(CHEMBL1689483)
Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@@H](Cc2cnc[nH]2)NC(=O)C(C)(C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCNC(=O)COCC(=O)Nc2ccc(CCC(=O)N3CCC3=O)cc2)NC1=O)C(=O)N[C@H]([C@@H](C)O)C(=O)N[C@@H](CCCCNC(C)=O)C(=O)NC(C)(C)C(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(C)=O)C(C)C
Show InChI InChI=1S/C116H168N28O32S2/c1-18-62(6)94-110(171)128-76(28-23-25-44-121-87(149)54-176-55-88(150)127-72-35-30-69(31-36-72)34-40-89(151)144-45-42-90(144)152)99(160)131-78(46-60(2)3)107(168)142-116(15,16)114(175)137-81(50-74-53-119-59-123-74)102(163)135-85(105(166)140-95(66(10)145)111(172)129-77(29-22-24-43-120-67(11)146)106(167)141-115(13,14)113(117)174)57-178-177-56-84(104(165)133-80(49-73-52-118-58-122-73)101(162)132-79(103(164)139-94)47-71-32-37-75(148)38-33-71)136-109(170)93(61(4)5)138-108(169)86(39-41-91(153)154)143(17)112(173)83(48-70-26-20-19-21-27-70)134-98(159)65(9)125-96(157)64(8)126-100(161)82(51-92(155)156)130-97(158)63(7)124-68(12)147/h19-21,26-27,30-33,35-38,52-53,58-66,76-86,93-95,145,148H,18,22-25,28-29,34,39-51,54-57H2,1-17H3,(H2,117,174)(H,118,122)(H,119,123)(H,120,146)(H,121,149)(H,124,147)(H,125,157)(H,126,161)(H,127,150)(H,128,171)(H,129,172)(H,130,158)(H,131,160)(H,132,162)(H,133,165)(H,134,159)(H,135,163)(H,136,170)(H,137,175)(H,138,169)(H,139,164)(H,140,166)(H,141,167)(H,142,168)(H,153,154)(H,155,156)/t62-,63-,64-,65-,66+,76-,77-,78-,79-,80-,81?,82-,83-,84-,85-,86-,93-,94-,95+/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

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PC cid
PC sid
UniChem

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Article
PubMed
n/an/an/a 0.100n/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human PlGF-1


J Med Chem 54: 1256-65 (2011)


Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1
More data for this
Ligand-Target Pair
Placenta growth factor


(Homo sapiens)
BDBM50339209
PNG
(CHEMBL1689479)
Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCNC(=O)COCC(=O)Nc2ccc(CCC(=O)N3CCC3=O)cc2)NC1=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc1ccccc1)NC(C)=O)C(C)C
Show InChI InChI=1S/C106H146N26O26S2/c1-9-59(6)89-103(155)119-71(19-13-14-39-112-83(137)51-158-52-84(138)117-66-29-22-62(23-30-66)28-36-85(139)132-42-38-86(132)140)93(145)125-79(43-57(2)3)105(157)131-41-16-21-82(131)101(153)124-78(48-68-50-111-56-115-68)97(149)126-81(100(152)130-90(60(7)133)104(156)120-72(20-15-40-113-106(108)109)92(144)121-74(91(107)143)44-64-24-31-69(135)32-25-64)54-160-159-53-80(99(151)123-77(47-67-49-110-55-114-67)96(148)122-76(98(150)129-89)46-65-26-33-70(136)34-27-65)127-102(154)88(58(4)5)128-94(146)73(35-37-87(141)142)118-95(147)75(116-61(8)134)45-63-17-11-10-12-18-63/h10-12,17-18,22-27,29-34,49-50,55-60,71-82,88-90,133,135-136H,9,13-16,19-21,28,35-48,51-54H2,1-8H3,(H2,107,143)(H,110,114)(H,111,115)(H,112,137)(H,116,134)(H,117,138)(H,118,147)(H,119,155)(H,120,156)(H,121,144)(H,122,148)(H,123,151)(H,124,153)(H,125,145)(H,126,149)(H,127,154)(H,128,146)(H,129,150)(H,130,152)(H,141,142)(H4,108,109,113)/t59-,60+,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,88-,89-,90-/m0/s1
PDB
MMDB

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KEGG

UniProtKB/SwissProt

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Article
PubMed
n/an/an/a 0.300n/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human PlGF-1


J Med Chem 54: 1256-65 (2011)


Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1
More data for this
Ligand-Target Pair
Placenta growth factor


(Homo sapiens)
BDBM50339210
PNG
(CHEMBL1689481)
Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCNC(=O)COCC(=O)Nc2ccc(CCC(=O)N3CCC3=O)cc2)NC1=O)C(=O)N[C@H]([C@@H](C)O)C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@H](Cc1ccc(O)cc1)C(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(C)=O)C(C)C
Show InChI InChI=1S/C116H161N29O31S2/c1-11-62(6)96-113(173)131-76(21-15-16-41-122-89(150)54-176-55-90(151)129-71-31-24-67(25-32-71)30-38-91(152)145-44-40-92(145)153)102(162)138-85(45-60(2)3)115(175)144-43-18-23-88(144)111(171)137-83(50-73-53-121-59-125-73)107(167)139-87(110(170)143-97(65(9)146)114(174)132-77(22-17-42-123-116(118)119)101(161)133-79(98(117)158)46-69-26-33-74(148)34-27-69)57-178-177-56-86(109(169)136-82(49-72-52-120-58-124-72)106(166)135-81(108(168)142-96)48-70-28-35-75(149)36-29-70)140-112(172)95(61(4)5)141-103(163)78(37-39-93(154)155)130-105(165)80(47-68-19-13-12-14-20-68)134-100(160)64(8)126-99(159)63(7)127-104(164)84(51-94(156)157)128-66(10)147/h12-14,19-20,24-29,31-36,52-53,58-65,76-88,95-97,146,148-149H,11,15-18,21-23,30,37-51,54-57H2,1-10H3,(H2,117,158)(H,120,124)(H,121,125)(H,122,150)(H,126,159)(H,127,164)(H,128,147)(H,129,151)(H,130,165)(H,131,173)(H,132,174)(H,133,161)(H,134,160)(H,135,166)(H,136,169)(H,137,171)(H,138,162)(H,139,167)(H,140,172)(H,141,163)(H,142,168)(H,143,170)(H,154,155)(H,156,157)(H4,118,119,123)/t62-,63-,64-,65+,76-,77+,78-,79+,80-,81-,82-,83-,84-,85-,86-,87-,88-,95-,96-,97+/m0/s1
PDB
MMDB

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KEGG

UniProtKB/SwissProt

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DrugBank
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PC cid
PC sid
UniChem

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Article
PubMed
n/an/an/a 0.300n/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human PlGF-1


J Med Chem 54: 1256-65 (2011)


Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1
More data for this
Ligand-Target Pair
Placenta growth factor


(Homo sapiens)
BDBM50339191
PNG
(CHEMBL1689460)
Show SMILES CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2ccccc2)NC(C)=O)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NC(=O)COCC(=O)Nc1ccc(CCC(=O)N2CCC2=O)cc1
Show InChI InChI=1S/C107H157N25O25S3/c1-58(2)46-79-107(156)131-43-23-31-82(131)102(151)122-77(49-68-52-111-57-113-68)97(146)124-80(100(149)118-73(30-19-22-42-110)95(144)127-88(59(3)4)103(152)119-74(39-45-158-11)93(142)116-72(29-18-21-41-109)94(143)126-84(136)54-157-53-83(135)115-67-35-32-64(33-36-67)34-37-85(137)132-44-38-86(132)138)55-159-160-56-81(125-104(153)89(60(5)6)128-99(148)78(50-87(139)140)121-96(145)75(114-63(10)134)47-65-24-13-12-14-25-65)101(150)117-71(28-17-20-40-108)92(141)120-76(48-66-51-112-70-27-16-15-26-69(66)70)98(147)129-90(61(7)8)105(154)130-91(62(9)133)106(155)123-79/h12-16,24-27,32-33,35-36,51-52,57-62,71-82,88-91,112,133H,17-23,28-31,34,37-50,53-56,108-110H2,1-11H3,(H,111,113)(H,114,134)(H,115,135)(H,116,142)(H,117,150)(H,118,149)(H,119,152)(H,120,141)(H,121,145)(H,122,151)(H,123,155)(H,124,146)(H,125,153)(H,127,144)(H,128,148)(H,129,147)(H,130,154)(H,139,140)(H,126,136,143)/t62-,71+,72+,73+,74+,75+,76+,77+,78+,79+,80+,81+,82+,88+,89+,90+,91+/m1/s1
PDB
MMDB

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KEGG

UniProtKB/SwissProt

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DrugBank
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PC cid
PC sid
UniChem

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Article
PubMed
n/an/an/a 4n/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human PlGF-1


J Med Chem 54: 1256-65 (2011)


Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1
More data for this
Ligand-Target Pair
Placenta growth factor


(Homo sapiens)
BDBM50339197
PNG
(CHEMBL1689466)
Show SMILES CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCNC(=O)COCC(=O)Nc1ccc(CCC(=O)N2CCC2=O)cc1)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2ccccc2)NC(C)=O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(C)C)C(N)=O
Show InChI InChI=1S/C99H139N23O25S3/c1-51(2)38-71-99(146)121-35-19-25-74(121)94(141)113-68(41-61-45-102-50-105-61)88(135)115-72(92(139)109-65(86(133)117-81(52(3)4)95(142)108-64(85(101)132)33-37-148-11)24-17-18-34-103-76(126)46-147-47-77(127)107-60-29-26-57(27-30-60)28-31-78(128)122-36-32-79(122)129)48-149-150-49-73(116-96(143)82(53(5)6)118-91(138)70(43-80(130)131)112-87(134)66(106-56(10)124)39-58-20-13-12-14-21-58)93(140)111-69(42-75(100)125)89(136)110-67(40-59-44-104-63-23-16-15-22-62(59)63)90(137)119-83(54(7)8)97(144)120-84(55(9)123)98(145)114-71/h12-16,20-23,26-27,29-30,44-45,50-55,64-74,81-84,104,123H,17-19,24-25,28,31-43,46-49H2,1-11H3,(H2,100,125)(H2,101,132)(H,102,105)(H,103,126)(H,106,124)(H,107,127)(H,108,142)(H,109,139)(H,110,136)(H,111,140)(H,112,134)(H,113,141)(H,114,145)(H,115,135)(H,116,143)(H,117,133)(H,118,138)(H,119,137)(H,120,144)(H,130,131)/t55-,64+,65+,66+,67+,68+,69+,70+,71+,72+,73+,74+,81+,82+,83+,84+/m1/s1
PDB
MMDB

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KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
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CHEMBL
PC cid
PC sid
UniChem

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Article
PubMed
n/an/an/a 4n/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human PlGF-1


J Med Chem 54: 1256-65 (2011)


Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1
More data for this
Ligand-Target Pair
Placenta growth factor


(Homo sapiens)
BDBM50339196
PNG
(CHEMBL1689465)
Show SMILES CC(C)C[C@@H]1NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C1=O)C(=O)N[C@@H](CCCCNC(C)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NC(=O)COCC(=O)Nc1ccc(CCC(=O)N2CCC2=O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccccc1)NC(C)=O)C(C)C)C(C)C)[C@@H](C)O
Show InChI InChI=1S/C102H144N24O26S2/c1-53(2)40-74-102(151)125-38-21-28-77(125)97(146)116-71(43-64-47-105-52-108-64)91(140)118-75(95(144)111-68(27-18-20-37-106-58(10)128)89(138)121-84(54(3)4)98(147)112-67(26-17-19-36-103)88(137)120-80(132)49-152-48-79(131)110-63-32-29-60(30-33-63)31-34-81(133)126-39-35-82(126)134)50-153-154-51-76(119-99(148)85(55(5)6)122-94(143)73(45-83(135)136)115-90(139)69(109-59(11)129)41-61-22-13-12-14-23-61)96(145)114-72(44-78(104)130)92(141)113-70(42-62-46-107-66-25-16-15-24-65(62)66)93(142)123-86(56(7)8)100(149)124-87(57(9)127)101(150)117-74/h12-16,22-25,29-30,32-33,46-47,52-57,67-77,84-87,107,127H,17-21,26-28,31,34-45,48-51,103H2,1-11H3,(H2,104,130)(H,105,108)(H,106,128)(H,109,129)(H,110,131)(H,111,144)(H,112,147)(H,113,141)(H,114,145)(H,115,139)(H,116,146)(H,117,150)(H,118,140)(H,119,148)(H,121,138)(H,122,143)(H,123,142)(H,124,149)(H,135,136)(H,120,132,137)/t57-,67+,68+,69+,70+,71+,72+,73+,74+,75+,76+,77+,84+,85+,86+,87+/m1/s1
PDB
MMDB

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UniProtKB/SwissProt

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UniChem

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Article
PubMed
n/an/an/a 5n/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human PlGF-1


J Med Chem 54: 1256-65 (2011)


Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1
More data for this
Ligand-Target Pair
Placenta growth factor


(Homo sapiens)
BDBM50339193
PNG
(CHEMBL1689463)
Show SMILES CSCC[C@H](NC(=O)[C@H](CCCCNC(=O)COCC(=O)Nc1ccc(CCC(=O)N2CCC2=O)cc1)NC(=O)[C@H](CCCCNC(C)=O)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2ccccc2)NC(C)=O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(N)=O
Show InChI InChI=1S/C102H144N24O26S3/c1-54(2)41-75-102(151)125-38-20-27-78(125)98(147)118-72(44-64-48-105-53-109-64)92(141)120-76(96(145)114-69(25-16-18-36-106-58(8)128)90(139)113-68(89(138)112-67(88(104)137)35-40-153-10)26-17-19-37-107-80(131)49-152-50-81(132)111-63-31-28-60(29-32-63)30-33-82(133)126-39-34-83(126)134)51-154-155-52-77(121-99(148)85(55(3)4)122-95(144)74(46-84(135)136)117-91(140)70(110-59(9)129)42-61-21-12-11-13-22-61)97(146)116-73(45-79(103)130)93(142)115-71(43-62-47-108-66-24-15-14-23-65(62)66)94(143)123-86(56(5)6)100(149)124-87(57(7)127)101(150)119-75/h11-15,21-24,28-29,31-32,47-48,53-57,67-78,85-87,108,127H,16-20,25-27,30,33-46,49-52H2,1-10H3,(H2,103,130)(H2,104,137)(H,105,109)(H,106,128)(H,107,131)(H,110,129)(H,111,132)(H,112,138)(H,113,139)(H,114,145)(H,115,142)(H,116,146)(H,117,140)(H,118,147)(H,119,150)(H,120,141)(H,121,148)(H,122,144)(H,123,143)(H,124,149)(H,135,136)/t57-,67+,68+,69+,70+,71+,72+,73+,74+,75+,76+,77+,78+,85+,86+,87+/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 5n/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human PlGF-1


J Med Chem 54: 1256-65 (2011)


Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1
More data for this
Ligand-Target Pair
Placenta growth factor


(Homo sapiens)
BDBM50339204
PNG
(CHEMBL1689473)
Show SMILES CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCNC(C)=O)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2ccccc2)NC(C)=O)C(C)C)C(=O)N[C@@H](CCCCNC(=O)COCC(=O)Nc2ccc(CCC(=O)N3CCC3=O)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(C)C)C(N)=O
Show InChI InChI=1S/C103H147N23O25S3/c1-55(2)43-76-103(150)125-40-22-29-79(125)98(145)117-74(46-66-49-105-54-109-66)93(140)119-77(96(143)114-71(28-18-20-38-106-60(10)128)91(138)121-85(56(3)4)99(146)112-69(89(104)136)37-42-152-12)52-153-154-53-78(120-100(147)86(57(5)6)122-95(142)75(47-84(134)135)116-92(139)72(110-61(11)129)44-63-23-14-13-15-24-63)97(144)113-70(27-19-21-39-107-80(130)50-151-51-81(131)111-65-33-30-62(31-34-65)32-35-82(132)126-41-36-83(126)133)90(137)115-73(45-64-48-108-68-26-17-16-25-67(64)68)94(141)123-87(58(7)8)101(148)124-88(59(9)127)102(149)118-76/h13-17,23-26,30-31,33-34,48-49,54-59,69-79,85-88,108,127H,18-22,27-29,32,35-47,50-53H2,1-12H3,(H2,104,136)(H,105,109)(H,106,128)(H,107,130)(H,110,129)(H,111,131)(H,112,146)(H,113,144)(H,114,143)(H,115,137)(H,116,139)(H,117,145)(H,118,149)(H,119,140)(H,120,147)(H,121,138)(H,122,142)(H,123,141)(H,124,148)(H,134,135)/t59-,69+,70+,71+,72+,73+,74+,75+,76+,77+,78+,79+,85+,86+,87+,88+/m1/s1
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n/an/an/a 6n/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human PlGF-1


J Med Chem 54: 1256-65 (2011)


Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1
More data for this
Ligand-Target Pair
Placenta growth factor


(Homo sapiens)
BDBM50339211
PNG
(CHEMBL1689482)
Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCNC(=O)COCC(=O)Nc2ccc(CCC(=O)N3CCC3=O)cc2)NC1=O)C(=O)N[C@H]([C@@H](C)O)C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@H](Cc1ccc(O)cc1)C(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(C)=O)C(C)C
Show InChI InChI=1S/C120H168N30O32S2/c1-13-64(6)99-116(178)134-79(23-17-18-43-126-92(155)56-182-57-93(156)133-74-33-26-70(27-34-74)32-40-94(157)150-46-42-95(150)158)106(168)142-86(47-62(2)3)119(181)149-45-20-25-91(149)114(176)140-84(52-76-55-125-61-129-76)109(171)143-89(112(174)147-100(68(10)151)117(179)135-80(24-19-44-127-120(122)123)105(167)136-81(101(121)163)48-72-28-35-77(153)36-29-72)59-184-183-58-88(111(173)139-83(51-75-54-124-60-128-75)108(170)138-82(110(172)146-99)49-73-30-37-78(154)38-31-73)144-115(177)98(63(4)5)145-113(175)90(39-41-96(159)160)148(12)118(180)87(50-71-21-15-14-16-22-71)141-104(166)67(9)131-102(164)66(8)132-107(169)85(53-97(161)162)137-103(165)65(7)130-69(11)152/h14-16,21-22,26-31,33-38,54-55,60-68,79-91,98-100,151,153-154H,13,17-20,23-25,32,39-53,56-59H2,1-12H3,(H2,121,163)(H,124,128)(H,125,129)(H,126,155)(H,130,152)(H,131,164)(H,132,169)(H,133,156)(H,134,178)(H,135,179)(H,136,167)(H,137,165)(H,138,170)(H,139,173)(H,140,176)(H,141,166)(H,142,168)(H,143,171)(H,144,177)(H,145,175)(H,146,172)(H,147,174)(H,159,160)(H,161,162)(H4,122,123,127)/t64-,65-,66-,67-,68+,79-,80+,81+,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,98-,99-,100+/m0/s1
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n/an/an/a 8n/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human PlGF-1


J Med Chem 54: 1256-65 (2011)


Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1
More data for this
Ligand-Target Pair
Placenta growth factor


(Homo sapiens)
BDBM50339195
PNG
(CHEMBL1689464)
Show SMILES CC(C)C[C@@H]1NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCCNC(C)=O)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C1=O)C(=O)N[C@@H](CCCCNC(C)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NC(=O)COCC(=O)Nc1ccc(CCC(=O)N2CCC2=O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccccc1)NC(C)=O)C(C)C)C(C)C)[C@@H](C)O
Show InChI InChI=1S/C106H152N24O26S2/c1-57(2)45-79-106(155)129-43-24-32-82(129)101(150)120-77(48-69-51-108-56-112-69)96(145)122-80(99(148)116-74(31-20-23-42-110-63(11)133)94(143)125-88(58(3)4)102(151)117-73(29-18-21-40-107)93(142)124-84(136)53-156-52-83(135)114-68-36-33-65(34-37-68)35-38-85(137)130-44-39-86(130)138)54-157-158-55-81(123-103(152)89(59(5)6)126-98(147)78(49-87(139)140)119-95(144)75(113-64(12)134)46-66-25-14-13-15-26-66)100(149)115-72(30-19-22-41-109-62(10)132)92(141)118-76(47-67-50-111-71-28-17-16-27-70(67)71)97(146)127-90(60(7)8)104(153)128-91(61(9)131)105(154)121-79/h13-17,25-28,33-34,36-37,50-51,56-61,72-82,88-91,111,131H,18-24,29-32,35,38-49,52-55,107H2,1-12H3,(H,108,112)(H,109,132)(H,110,133)(H,113,134)(H,114,135)(H,115,149)(H,116,148)(H,117,151)(H,118,141)(H,119,144)(H,120,150)(H,121,154)(H,122,145)(H,123,152)(H,125,143)(H,126,147)(H,127,146)(H,128,153)(H,139,140)(H,124,136,142)/t61-,72+,73+,74+,75+,76+,77+,78+,79+,80+,81+,82+,88+,89+,90+,91+/m1/s1
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n/an/an/a 8n/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human PlGF-1


J Med Chem 54: 1256-65 (2011)


Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1
More data for this
Ligand-Target Pair
Placenta growth factor


(Homo sapiens)
BDBM50129952
PNG
(2-(3-(5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-c...)
Show SMILES Oc1ccc(cc1)-c1cc(=O)c2c(O)cc(O)c(-c3cc(ccc3O)-c3cc(O)c4c(cc(O)cc4=O)o3)c2o1
Show InChI InChI=1S/C30H18O10/c31-15-4-1-13(2-5-15)24-12-23(38)29-21(36)10-20(35)27(30(29)40-24)17-7-14(3-6-18(17)33)25-11-22(37)28-19(34)8-16(32)9-26(28)39-25/h1-12,31-33,35-37H
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n/an/an/a 8.20n/an/an/an/an/a



Universit£ degli Studi di Salerno

Curated by ChEMBL


Assay Description
Binding affinity to recombinant PIGF1 (unknown origin) measured for 60 seconds by surface plasmon resonance assay


J Nat Prod 76: 29-35 (2013)


Article DOI: 10.1021/np300614u
BindingDB Entry DOI: 10.7270/Q24F1S3K
More data for this
Ligand-Target Pair
Placenta growth factor


(Homo sapiens)
BDBM50339201
PNG
(CHEMBL1689470)
Show SMILES CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCNC(C)=O)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2ccccc2)NC(C)=O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCNC(=O)COCC(=O)Nc2ccc(CCC(=O)N3CCC3=O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(C)C)C(N)=O
Show InChI InChI=1S/C103H146N24O25S3/c1-55(2)42-76-103(151)126-39-21-28-79(126)99(147)119-73(45-65-49-106-54-110-65)93(141)121-77(97(145)114-70(27-17-19-37-107-59(9)128)91(139)123-86(56(3)4)100(148)113-68(89(105)137)36-41-153-11)52-154-155-53-78(122-102(150)88(58(7)8)125-96(144)75(47-85(135)136)118-92(140)71(111-60(10)129)43-62-22-13-12-14-23-62)98(146)117-74(46-80(104)130)94(142)116-72(44-63-48-109-67-25-16-15-24-66(63)67)95(143)124-87(57(5)6)101(149)115-69(90(138)120-76)26-18-20-38-108-81(131)50-152-51-82(132)112-64-32-29-61(30-33-64)31-34-83(133)127-40-35-84(127)134/h12-16,22-25,29-30,32-33,48-49,54-58,68-79,86-88,109H,17-21,26-28,31,34-47,50-53H2,1-11H3,(H2,104,130)(H2,105,137)(H,106,110)(H,107,128)(H,108,131)(H,111,129)(H,112,132)(H,113,148)(H,114,145)(H,115,149)(H,116,142)(H,117,146)(H,118,140)(H,119,147)(H,120,138)(H,121,141)(H,122,150)(H,123,139)(H,124,143)(H,125,144)(H,135,136)/t68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,86-,87-,88-/m0/s1
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n/an/an/a 9n/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human PlGF-1


J Med Chem 54: 1256-65 (2011)


Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1
More data for this
Ligand-Target Pair
Placenta growth factor


(Homo sapiens)
BDBM50339212
PNG
(CHEMBL1689483)
Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@@H](Cc2cnc[nH]2)NC(=O)C(C)(C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCNC(=O)COCC(=O)Nc2ccc(CCC(=O)N3CCC3=O)cc2)NC1=O)C(=O)N[C@H]([C@@H](C)O)C(=O)N[C@@H](CCCCNC(C)=O)C(=O)NC(C)(C)C(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(C)=O)C(C)C
Show InChI InChI=1S/C116H168N28O32S2/c1-18-62(6)94-110(171)128-76(28-23-25-44-121-87(149)54-176-55-88(150)127-72-35-30-69(31-36-72)34-40-89(151)144-45-42-90(144)152)99(160)131-78(46-60(2)3)107(168)142-116(15,16)114(175)137-81(50-74-53-119-59-123-74)102(163)135-85(105(166)140-95(66(10)145)111(172)129-77(29-22-24-43-120-67(11)146)106(167)141-115(13,14)113(117)174)57-178-177-56-84(104(165)133-80(49-73-52-118-58-122-73)101(162)132-79(103(164)139-94)47-71-32-37-75(148)38-33-71)136-109(170)93(61(4)5)138-108(169)86(39-41-91(153)154)143(17)112(173)83(48-70-26-20-19-21-27-70)134-98(159)65(9)125-96(157)64(8)126-100(161)82(51-92(155)156)130-97(158)63(7)124-68(12)147/h19-21,26-27,30-33,35-38,52-53,58-66,76-86,93-95,145,148H,18,22-25,28-29,34,39-51,54-57H2,1-17H3,(H2,117,174)(H,118,122)(H,119,123)(H,120,146)(H,121,149)(H,124,147)(H,125,157)(H,126,161)(H,127,150)(H,128,171)(H,129,172)(H,130,158)(H,131,160)(H,132,162)(H,133,165)(H,134,159)(H,135,163)(H,136,170)(H,137,175)(H,138,169)(H,139,164)(H,140,166)(H,141,167)(H,142,168)(H,153,154)(H,155,156)/t62-,63-,64-,65-,66+,76-,77-,78-,79-,80-,81?,82-,83-,84-,85-,86-,93-,94-,95+/m0/s1
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n/an/an/a 9n/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human PlGF-2


J Med Chem 54: 1256-65 (2011)


Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1
More data for this
Ligand-Target Pair
Placenta growth factor


(Homo sapiens)
BDBM50428820
PNG
(CHEMBL2335722)
Show SMILES O[C@H]1Cc2c(O)cc(O)c([C@@H]3C[C@H](Oc4cc(O)cc(O)c34)c3ccc(O)cc3)c2O[C@@H]1c1ccc(O)cc1
Show InChI InChI=1S/C30H26O9/c31-16-5-1-14(2-6-16)25-12-20(27-22(35)9-18(33)10-26(27)38-25)28-23(36)13-21(34)19-11-24(37)29(39-30(19)28)15-3-7-17(32)8-4-15/h1-10,13,20,24-25,29,31-37H,11-12H2/t20-,24+,25+,29-/m1/s1
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n/an/an/a 11n/an/an/an/an/a



Universit£ degli Studi di Salerno

Curated by ChEMBL


Assay Description
Binding affinity to recombinant PIGF1 (unknown origin) measured for 60 seconds by surface plasmon resonance assay


J Nat Prod 76: 29-35 (2013)


Article DOI: 10.1021/np300614u
BindingDB Entry DOI: 10.7270/Q24F1S3K
More data for this
Ligand-Target Pair
Placenta growth factor


(Homo sapiens)
BDBM50428819
PNG
(GERANIN B)
Show SMILES O[C@H]1Cc2c(O)cc3O[C@@]4(Oc5cc(O)cc(O)c5[C@@H]([C@H]4O)c3c2O[C@@H]1c1ccc(O)cc1)c1ccc(O)c(O)c1
Show InChI InChI=1S/C30H24O11/c31-14-4-1-12(2-5-14)27-21(37)10-16-18(34)11-23-25(28(16)39-27)26-24-20(36)8-15(32)9-22(24)40-30(41-23,29(26)38)13-3-6-17(33)19(35)7-13/h1-9,11,21,26-27,29,31-38H,10H2/t21-,26+,27+,29+,30-/m0/s1
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n/an/an/a 23n/an/an/an/an/a



Universit£ degli Studi di Salerno

Curated by ChEMBL


Assay Description
Binding affinity to recombinant PIGF1 (unknown origin) measured for 60 seconds by surface plasmon resonance assay


J Nat Prod 76: 29-35 (2013)


Article DOI: 10.1021/np300614u
BindingDB Entry DOI: 10.7270/Q24F1S3K
More data for this
Ligand-Target Pair
Placenta growth factor


(Mus musculus)
BDBM50339212
PNG
(CHEMBL1689483)
Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@@H](Cc2cnc[nH]2)NC(=O)C(C)(C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCNC(=O)COCC(=O)Nc2ccc(CCC(=O)N3CCC3=O)cc2)NC1=O)C(=O)N[C@H]([C@@H](C)O)C(=O)N[C@@H](CCCCNC(C)=O)C(=O)NC(C)(C)C(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(C)=O)C(C)C
Show InChI InChI=1S/C116H168N28O32S2/c1-18-62(6)94-110(171)128-76(28-23-25-44-121-87(149)54-176-55-88(150)127-72-35-30-69(31-36-72)34-40-89(151)144-45-42-90(144)152)99(160)131-78(46-60(2)3)107(168)142-116(15,16)114(175)137-81(50-74-53-119-59-123-74)102(163)135-85(105(166)140-95(66(10)145)111(172)129-77(29-22-24-43-120-67(11)146)106(167)141-115(13,14)113(117)174)57-178-177-56-84(104(165)133-80(49-73-52-118-58-122-73)101(162)132-79(103(164)139-94)47-71-32-37-75(148)38-33-71)136-109(170)93(61(4)5)138-108(169)86(39-41-91(153)154)143(17)112(173)83(48-70-26-20-19-21-27-70)134-98(159)65(9)125-96(157)64(8)126-100(161)82(51-92(155)156)130-97(158)63(7)124-68(12)147/h19-21,26-27,30-33,35-38,52-53,58-66,76-86,93-95,145,148H,18,22-25,28-29,34,39-51,54-57H2,1-17H3,(H2,117,174)(H,118,122)(H,119,123)(H,120,146)(H,121,149)(H,124,147)(H,125,157)(H,126,161)(H,127,150)(H,128,171)(H,129,172)(H,130,158)(H,131,160)(H,132,162)(H,133,165)(H,134,159)(H,135,163)(H,136,170)(H,137,175)(H,138,169)(H,139,164)(H,140,166)(H,141,167)(H,142,168)(H,153,154)(H,155,156)/t62-,63-,64-,65-,66+,76-,77-,78-,79-,80-,81?,82-,83-,84-,85-,86-,93-,94-,95+/m0/s1
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to mouse PlGF


J Med Chem 54: 1256-65 (2011)


Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1
More data for this
Ligand-Target Pair
Placenta growth factor


(Homo sapiens)
BDBM50339191
PNG
(CHEMBL1689460)
Show SMILES CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2ccccc2)NC(C)=O)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NC(=O)COCC(=O)Nc1ccc(CCC(=O)N2CCC2=O)cc1
Show InChI InChI=1S/C107H157N25O25S3/c1-58(2)46-79-107(156)131-43-23-31-82(131)102(151)122-77(49-68-52-111-57-113-68)97(146)124-80(100(149)118-73(30-19-22-42-110)95(144)127-88(59(3)4)103(152)119-74(39-45-158-11)93(142)116-72(29-18-21-41-109)94(143)126-84(136)54-157-53-83(135)115-67-35-32-64(33-36-67)34-37-85(137)132-44-38-86(132)138)55-159-160-56-81(125-104(153)89(60(5)6)128-99(148)78(50-87(139)140)121-96(145)75(114-63(10)134)47-65-24-13-12-14-25-65)101(150)117-71(28-17-20-40-108)92(141)120-76(48-66-51-112-70-27-16-15-26-69(66)70)98(147)129-90(61(7)8)105(154)130-91(62(9)133)106(155)123-79/h12-16,24-27,32-33,35-36,51-52,57-62,71-82,88-91,112,133H,17-23,28-31,34,37-50,53-56,108-110H2,1-11H3,(H,111,113)(H,114,134)(H,115,135)(H,116,142)(H,117,150)(H,118,149)(H,119,152)(H,120,141)(H,121,145)(H,122,151)(H,123,155)(H,124,146)(H,125,153)(H,127,144)(H,128,148)(H,129,147)(H,130,154)(H,139,140)(H,126,136,143)/t62-,71+,72+,73+,74+,75+,76+,77+,78+,79+,80+,81+,82+,88+,89+,90+,91+/m1/s1
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n/an/an/a 100n/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human PlGF-2


J Med Chem 54: 1256-65 (2011)


Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1
More data for this
Ligand-Target Pair
Placenta growth factor


(Homo sapiens)
BDBM50339192
PNG
(CHEMBL1689461)
Show SMILES CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)COCC(=O)Nc2ccc(CCC(=O)N3CCC3=O)cc2)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(C)C)C(N)=O
Show InChI InChI=1S/C99H143N23O23S3/c1-53(2)41-72-99(144)121-38-20-27-75(121)94(139)113-70(44-62-47-103-52-105-62)89(134)115-73(92(137)110-67(26-17-19-37-101)87(132)117-81(54(3)4)95(140)108-65(85(102)130)35-40-146-10)50-147-148-51-74(93(138)109-66(25-16-18-36-100)86(131)111-69(43-60-46-104-64-24-15-14-23-63(60)64)90(135)119-83(56(7)8)97(142)120-84(57(9)123)98(143)114-72)116-96(141)82(55(5)6)118-91(136)71(45-80(128)129)112-88(133)68(42-59-21-12-11-13-22-59)107-77(125)49-145-48-76(124)106-61-31-28-58(29-32-61)30-33-78(126)122-39-34-79(122)127/h11-15,21-24,28-29,31-32,46-47,52-57,65-75,81-84,104,123H,16-20,25-27,30,33-45,48-51,100-101H2,1-10H3,(H2,102,130)(H,103,105)(H,106,124)(H,107,125)(H,108,140)(H,109,138)(H,110,137)(H,111,131)(H,112,133)(H,113,139)(H,114,143)(H,115,134)(H,116,141)(H,117,132)(H,118,136)(H,119,135)(H,120,142)(H,128,129)/t57-,65+,66+,67+,68+,69+,70+,71+,72+,73+,74+,75+,81+,82+,83+,84+/m1/s1
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n/an/an/a 200n/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human PlGF-1


J Med Chem 54: 1256-65 (2011)


Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1
More data for this
Ligand-Target Pair
Placenta growth factor


(Homo sapiens)
BDBM50428821
PNG
(PROANTHOCYANIDIN A1)
Show SMILES O[C@H]1Cc2c(O)cc3O[C@@]4(Oc5cc(O)cc(O)c5[C@@H]([C@H]4O)c3c2O[C@@H]1c1ccc(O)c(O)c1)c1ccc(O)c(O)c1
Show InChI InChI=1S/C30H24O12/c31-13-7-20(37)24-22(8-13)41-30(12-2-4-16(33)19(36)6-12)29(39)26(24)25-23(42-30)10-17(34)14-9-21(38)27(40-28(14)25)11-1-3-15(32)18(35)5-11/h1-8,10,21,26-27,29,31-39H,9H2/t21-,26+,27+,29+,30-/m0/s1
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n/an/an/a 394n/an/an/an/an/a



Universit£ degli Studi di Salerno

Curated by ChEMBL


Assay Description
Binding affinity to recombinant PIGF1 (unknown origin) measured for 60 seconds by surface plasmon resonance assay


J Nat Prod 76: 29-35 (2013)


Article DOI: 10.1021/np300614u
BindingDB Entry DOI: 10.7270/Q24F1S3K
More data for this
Ligand-Target Pair
Placenta growth factor


(Mus musculus)
BDBM50339191
PNG
(CHEMBL1689460)
Show SMILES CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2ccccc2)NC(C)=O)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NC(=O)COCC(=O)Nc1ccc(CCC(=O)N2CCC2=O)cc1
Show InChI InChI=1S/C107H157N25O25S3/c1-58(2)46-79-107(156)131-43-23-31-82(131)102(151)122-77(49-68-52-111-57-113-68)97(146)124-80(100(149)118-73(30-19-22-42-110)95(144)127-88(59(3)4)103(152)119-74(39-45-158-11)93(142)116-72(29-18-21-41-109)94(143)126-84(136)54-157-53-83(135)115-67-35-32-64(33-36-67)34-37-85(137)132-44-38-86(132)138)55-159-160-56-81(125-104(153)89(60(5)6)128-99(148)78(50-87(139)140)121-96(145)75(114-63(10)134)47-65-24-13-12-14-25-65)101(150)117-71(28-17-20-40-108)92(141)120-76(48-66-51-112-70-27-16-15-26-69(66)70)98(147)129-90(61(7)8)105(154)130-91(62(9)133)106(155)123-79/h12-16,24-27,32-33,35-36,51-52,57-62,71-82,88-91,112,133H,17-23,28-31,34,37-50,53-56,108-110H2,1-11H3,(H,111,113)(H,114,134)(H,115,135)(H,116,142)(H,117,150)(H,118,149)(H,119,152)(H,120,141)(H,121,145)(H,122,151)(H,123,155)(H,124,146)(H,125,153)(H,127,144)(H,128,148)(H,129,147)(H,130,154)(H,139,140)(H,126,136,143)/t62-,71+,72+,73+,74+,75+,76+,77+,78+,79+,80+,81+,82+,88+,89+,90+,91+/m1/s1
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to mouse PlGF


J Med Chem 54: 1256-65 (2011)


Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1
More data for this
Ligand-Target Pair
Placenta growth factor


(Homo sapiens)
BDBM50339200
PNG
(CHEMBL1689469)
Show SMILES CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCNC(C)=O)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2ccccc2)NC(C)=O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCNC(=O)COCC(=O)Nc2ccc(CCC(=O)N3CCC3=O)cc2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(C)C)C(N)=O
Show InChI InChI=1S/C101H142N24O26S3/c1-53(2)83(97(146)111-66(87(103)136)35-40-152-10)120-88(137)67(25-16-18-36-105-57(8)127)112-94(143)74-50-153-154-51-75(119-98(147)84(54(3)4)121-93(142)73(45-82(134)135)116-89(138)69(109-58(9)128)41-60-21-12-11-13-22-60)95(144)115-72(44-77(102)129)91(140)114-70(42-61-46-107-65-24-15-14-23-64(61)65)92(141)122-85(55(5)6)99(148)123-86(56(7)126)100(149)113-68(101(150)124-38-20-27-76(124)96(145)117-71(90(139)118-74)43-63-47-104-52-108-63)26-17-19-37-106-78(130)48-151-49-79(131)110-62-31-28-59(29-32-62)30-33-80(132)125-39-34-81(125)133/h11-15,21-24,28-29,31-32,46-47,52-56,66-76,83-86,107,126H,16-20,25-27,30,33-45,48-51H2,1-10H3,(H2,102,129)(H2,103,136)(H,104,108)(H,105,127)(H,106,130)(H,109,128)(H,110,131)(H,111,146)(H,112,143)(H,113,149)(H,114,140)(H,115,144)(H,116,138)(H,117,145)(H,118,139)(H,119,147)(H,120,137)(H,121,142)(H,122,141)(H,123,148)(H,134,135)/t56-,66+,67+,68+,69+,70+,71+,72+,73+,74+,75+,76+,83+,84+,85+,86+/m1/s1
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n/an/an/a>1.00E+3n/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human PlGF-1


J Med Chem 54: 1256-65 (2011)


Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1
More data for this
Ligand-Target Pair
Placenta growth factor


(Homo sapiens)
BDBM50339199
PNG
(CHEMBL1689468)
Show SMILES CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCNC(C)=O)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2ccccc2)NC(C)=O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(=O)COCC(=O)Nc2ccc(CCC(=O)N3CCC3=O)cc2)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(C)C)C(N)=O
Show InChI InChI=1S/C102H146N24O26S3/c1-53(2)40-70-91(140)113-68(26-19-21-37-107-79(131)48-152-49-80(132)111-63-31-28-60(29-32-63)30-33-81(133)126-38-34-82(126)134)89(138)116-73(43-64-47-105-52-109-64)93(142)120-76(97(146)114-69(27-18-20-36-106-58(10)128)90(139)122-84(54(3)4)99(148)112-67(88(104)137)35-39-153-12)50-154-155-51-77(121-100(149)85(55(5)6)123-96(145)75(45-83(135)136)118-92(141)71(110-59(11)129)41-61-22-14-13-15-23-61)98(147)117-74(44-78(103)130)94(143)115-72(42-62-46-108-66-25-17-16-24-65(62)66)95(144)124-86(56(7)8)101(150)125-87(57(9)127)102(151)119-70/h13-17,22-25,28-29,31-32,46-47,52-57,67-77,84-87,108,127H,18-21,26-27,30,33-45,48-51H2,1-12H3,(H2,103,130)(H2,104,137)(H,105,109)(H,106,128)(H,107,131)(H,110,129)(H,111,132)(H,112,148)(H,113,140)(H,114,146)(H,115,143)(H,116,138)(H,117,147)(H,118,141)(H,119,151)(H,120,142)(H,121,149)(H,122,139)(H,123,145)(H,124,144)(H,125,150)(H,135,136)/t57-,67+,68+,69+,70+,71+,72+,73+,74+,75+,76+,77+,84+,85+,86+,87+/m1/s1
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n/an/an/a>1.00E+3n/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human PlGF-1


J Med Chem 54: 1256-65 (2011)


Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1
More data for this
Ligand-Target Pair
Placenta growth factor


(Homo sapiens)
BDBM50339198
PNG
(CHEMBL1689467)
Show SMILES CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCNC(C)=O)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2ccccc2)NC(C)=O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)COCC(=O)Nc2ccc(CCC(=O)N3CCC3=O)cc2)C(=O)N1)C(C)C)C(N)=O
Show InChI InChI=1S/C101H146N22O26S3/c1-53(2)43-73-101(148)122-40-22-29-76(122)96(143)111-67(27-19-21-39-105-78(128)49-149-50-79(129)108-63-33-30-60(31-34-63)32-35-80(130)123-41-36-81(123)131)88(135)116-74(94(141)110-68(28-18-20-38-104-58(10)125)89(136)118-83(54(3)4)97(144)109-66(87(103)134)37-42-150-12)51-151-152-52-75(117-98(145)84(55(5)6)119-93(140)72(47-82(132)133)114-90(137)69(107-59(11)126)44-61-23-14-13-15-24-61)95(142)113-71(46-77(102)127)91(138)112-70(45-62-48-106-65-26-17-16-25-64(62)65)92(139)120-85(56(7)8)99(146)121-86(57(9)124)100(147)115-73/h13-17,23-26,30-31,33-34,48,53-57,66-76,83-86,106,124H,18-22,27-29,32,35-47,49-52H2,1-12H3,(H2,102,127)(H2,103,134)(H,104,125)(H,105,128)(H,107,126)(H,108,129)(H,109,144)(H,110,141)(H,111,143)(H,112,138)(H,113,142)(H,114,137)(H,115,147)(H,116,135)(H,117,145)(H,118,136)(H,119,140)(H,120,139)(H,121,146)(H,132,133)/t57-,66+,67+,68+,69+,70+,71+,72+,73+,74+,75+,76+,83+,84+,85+,86+/m1/s1
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n/an/an/a>1.00E+3n/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human PlGF-1


J Med Chem 54: 1256-65 (2011)


Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1
More data for this
Ligand-Target Pair
Placenta growth factor


(Homo sapiens)
BDBM50339194
PNG
(CHEMBL1689456)
Show SMILES CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2ccccc2)NC(C)=O)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(C)C)C(N)=O
Show InChI InChI=1S/C85H129N21O19S3/c1-44(2)34-62-85(125)106-32-21-28-65(106)80(120)98-60(37-52-40-89-43-91-52)75(115)100-63(78(118)95-57(27-18-20-31-87)73(113)102-67(45(3)4)81(121)93-55(71(88)111)29-33-126-11)41-127-128-42-64(101-82(122)68(46(5)6)103-77(117)61(38-66(109)110)97-74(114)58(92-49(10)108)35-50-22-13-12-14-23-50)79(119)94-56(26-17-19-30-86)72(112)96-59(36-51-39-90-54-25-16-15-24-53(51)54)76(116)104-69(47(7)8)83(123)105-70(48(9)107)84(124)99-62/h12-16,22-25,39-40,43-48,55-65,67-70,90,107H,17-21,26-38,41-42,86-87H2,1-11H3,(H2,88,111)(H,89,91)(H,92,108)(H,93,121)(H,94,119)(H,95,118)(H,96,112)(H,97,114)(H,98,120)(H,99,124)(H,100,115)(H,101,122)(H,102,113)(H,103,117)(H,104,116)(H,105,123)(H,109,110)/t48-,55+,56+,57+,58+,59+,60+,61+,62+,63+,64+,65+,67+,68+,69+,70+/m1/s1
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n/an/an/a 1.00E+3n/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human PlGF-1


J Med Chem 54: 1256-65 (2011)


Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1
More data for this
Ligand-Target Pair
Placenta growth factor


(Homo sapiens)
BDBM50339202
PNG
(CHEMBL1689471)
Show SMILES CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCNC(C)=O)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2ccccc2)NC(C)=O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CCCCNC(=O)COCC(=O)Nc2ccc(CCC(=O)N3CCC3=O)cc2)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(C)C)C(N)=O
Show InChI InChI=1S/C102H144N24O26S3/c1-54(2)41-75-102(151)125-38-20-27-78(125)98(147)118-72(44-64-48-105-53-109-64)93(142)120-76(96(145)114-68(25-16-18-36-106-58(8)128)89(138)122-85(55(3)4)99(148)112-67(88(104)137)35-40-153-10)51-154-155-52-77(121-100(149)86(56(5)6)123-95(144)74(46-84(135)136)117-91(140)70(110-59(9)129)42-61-21-12-11-13-22-61)97(146)116-73(45-79(103)130)94(143)115-71(43-62-47-108-66-24-15-14-23-65(62)66)92(141)113-69(90(139)124-87(57(7)127)101(150)119-75)26-17-19-37-107-80(131)49-152-50-81(132)111-63-31-28-60(29-32-63)30-33-82(133)126-39-34-83(126)134/h11-15,21-24,28-29,31-32,47-48,53-57,67-78,85-87,108,127H,16-20,25-27,30,33-46,49-52H2,1-10H3,(H2,103,130)(H2,104,137)(H,105,109)(H,106,128)(H,107,131)(H,110,129)(H,111,132)(H,112,148)(H,113,141)(H,114,145)(H,115,143)(H,116,146)(H,117,140)(H,118,147)(H,119,150)(H,120,142)(H,121,149)(H,122,138)(H,123,144)(H,124,139)(H,135,136)/t57-,67+,68+,69+,70+,71+,72+,73+,74+,75+,76+,77+,78+,85+,86+,87+/m1/s1
PDB
MMDB

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UniProtKB/SwissProt

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n/an/an/a>1.00E+3n/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human PlGF-1


J Med Chem 54: 1256-65 (2011)


Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1
More data for this
Ligand-Target Pair
Placenta growth factor


(Homo sapiens)
BDBM50339203
PNG
(CHEMBL1689472)
Show SMILES CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCNC(C)=O)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2ccccc2)NC(C)=O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCNC(=O)COCC(=O)Nc2ccc(CCC(=O)N3CCC3=O)cc2)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(C)C)C(N)=O
Show InChI InChI=1S/C96H143N23O26S3/c1-50(2)39-68-96(144)118-36-20-25-71(118)91(139)110-65(41-60-44-99-49-102-60)86(134)112-69(89(137)107-63(23-16-18-34-100-55(10)121)84(132)114-78(51(3)4)92(140)105-61(82(98)130)33-38-146-12)47-147-148-48-70(113-93(141)79(52(5)6)116-88(136)67(43-77(128)129)109-85(133)64(103-56(11)122)40-58-21-14-13-15-22-58)90(138)108-66(42-72(97)123)87(135)106-62(83(131)115-80(53(7)8)94(142)117-81(54(9)120)95(143)111-68)24-17-19-35-101-73(124)45-145-46-74(125)104-59-29-26-57(27-30-59)28-31-75(126)119-37-32-76(119)127/h13-15,21-22,26-27,29-30,44,49-54,61-71,78-81,120H,16-20,23-25,28,31-43,45-48H2,1-12H3,(H2,97,123)(H2,98,130)(H,99,102)(H,100,121)(H,101,124)(H,103,122)(H,104,125)(H,105,140)(H,106,135)(H,107,137)(H,108,138)(H,109,133)(H,110,139)(H,111,143)(H,112,134)(H,113,141)(H,114,132)(H,115,131)(H,116,136)(H,117,142)(H,128,129)/t54-,61+,62+,63+,64+,65+,66+,67+,68+,69+,70+,71+,78+,79+,80+,81+/m1/s1
PDB
MMDB

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UniProtKB/SwissProt

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n/an/an/a>1.00E+3n/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human PlGF-1


J Med Chem 54: 1256-65 (2011)


Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1
More data for this
Ligand-Target Pair
Placenta growth factor


(Homo sapiens)
BDBM50339208
PNG
(CHEMBL1689477)
Show SMILES CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCNC(C)=O)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)COCC(=O)Nc2ccc(CCC(=O)N3CCC3=O)cc2)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(C)C)C(N)=O
Show InChI InChI=1S/C99H139N23O25S3/c1-51(2)38-71-99(146)121-35-19-25-74(121)94(141)113-68(41-61-45-102-50-105-61)88(135)115-72(92(139)109-65(24-17-18-34-103-56(10)124)86(133)117-81(52(3)4)95(142)108-64(85(101)132)33-37-148-11)48-149-150-49-73(93(140)111-69(42-75(100)125)89(136)110-67(40-59-44-104-63-23-16-15-22-62(59)63)90(137)119-83(54(7)8)97(144)120-84(55(9)123)98(145)114-71)116-96(143)82(53(5)6)118-91(138)70(43-80(130)131)112-87(134)66(39-58-20-13-12-14-21-58)107-77(127)47-147-46-76(126)106-60-29-26-57(27-30-60)28-31-78(128)122-36-32-79(122)129/h12-16,20-23,26-27,29-30,44-45,50-55,64-74,81-84,104,123H,17-19,24-25,28,31-43,46-49H2,1-11H3,(H2,100,125)(H2,101,132)(H,102,105)(H,103,124)(H,106,126)(H,107,127)(H,108,142)(H,109,139)(H,110,136)(H,111,140)(H,112,134)(H,113,141)(H,114,145)(H,115,135)(H,116,143)(H,117,133)(H,118,138)(H,119,137)(H,120,144)(H,130,131)/t55-,64+,65+,66+,67+,68+,69+,70+,71+,72+,73+,74+,81+,82+,83+,84+/m1/s1
PDB
MMDB

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UniProtKB/SwissProt

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n/an/an/a>1.00E+3n/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human PlGF-1


J Med Chem 54: 1256-65 (2011)


Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1
More data for this
Ligand-Target Pair
Placenta growth factor


(Homo sapiens)
BDBM50339205
PNG
(CHEMBL1689474)
Show SMILES CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCNC(C)=O)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](CCCCNC(=O)COCC(=O)Nc2ccc(CCC(=O)N3CCC3=O)cc2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2ccccc2)NC(C)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(C)C)C(N)=O
Show InChI InChI=1S/C102H144N24O26S3/c1-54(2)41-75-102(151)125-38-20-27-78(125)98(147)118-72(44-64-48-105-53-109-64)92(141)121-76(96(145)114-69(26-16-18-36-106-58(8)128)90(139)122-85(55(3)4)99(148)112-67(88(104)137)35-40-153-10)51-154-155-52-77(97(146)116-73(45-79(103)130)93(142)115-71(43-62-47-108-66-24-15-14-23-65(62)66)95(144)123-86(56(5)6)100(149)124-87(57(7)127)101(150)119-75)120-89(138)68(113-94(143)74(46-84(135)136)117-91(140)70(110-59(9)129)42-61-21-12-11-13-22-61)25-17-19-37-107-80(131)49-152-50-81(132)111-63-31-28-60(29-32-63)30-33-82(133)126-39-34-83(126)134/h11-15,21-24,28-29,31-32,47-48,53-57,67-78,85-87,108,127H,16-20,25-27,30,33-46,49-52H2,1-10H3,(H2,103,130)(H2,104,137)(H,105,109)(H,106,128)(H,107,131)(H,110,129)(H,111,132)(H,112,148)(H,113,143)(H,114,145)(H,115,142)(H,116,146)(H,117,140)(H,118,147)(H,119,150)(H,120,138)(H,121,141)(H,122,139)(H,123,144)(H,124,149)(H,135,136)/t57-,67+,68+,69+,70+,71+,72+,73+,74+,75+,76+,77+,78+,85+,86+,87+/m1/s1
PDB
MMDB

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KEGG

UniProtKB/SwissProt

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UniChem

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Article
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n/an/an/a>1.00E+3n/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human PlGF-1


J Med Chem 54: 1256-65 (2011)


Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1
More data for this
Ligand-Target Pair
Placenta growth factor


(Homo sapiens)
BDBM50339206
PNG
(CHEMBL1689475)
Show SMILES CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCNC(C)=O)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCNC(=O)COCC(=O)Nc2ccc(CCC(=O)N3CCC3=O)cc2)NC(=O)[C@H](Cc2ccccc2)NC(C)=O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(C)C)C(N)=O
Show InChI InChI=1S/C103H148N24O24S3/c1-55(2)43-76-103(150)126-40-22-29-79(126)98(145)118-74(46-66-49-106-54-110-66)93(140)120-77(96(143)115-71(27-18-20-38-107-60(10)129)91(138)122-85(56(3)4)99(146)113-69(89(105)136)37-42-152-12)52-153-154-53-78(97(144)117-75(47-80(104)131)94(141)116-73(45-64-48-109-68-26-17-16-25-67(64)68)95(142)124-87(58(7)8)101(148)125-88(59(9)128)102(149)119-76)121-100(147)86(57(5)6)123-90(137)70(114-92(139)72(111-61(11)130)44-63-23-14-13-15-24-63)28-19-21-39-108-81(132)50-151-51-82(133)112-65-33-30-62(31-34-65)32-35-83(134)127-41-36-84(127)135/h13-17,23-26,30-31,33-34,48-49,54-59,69-79,85-88,109,128H,18-22,27-29,32,35-47,50-53H2,1-12H3,(H2,104,131)(H2,105,136)(H,106,110)(H,107,129)(H,108,132)(H,111,130)(H,112,133)(H,113,146)(H,114,139)(H,115,143)(H,116,141)(H,117,144)(H,118,145)(H,119,149)(H,120,140)(H,121,147)(H,122,138)(H,123,137)(H,124,142)(H,125,148)/t59-,69+,70+,71+,72+,73+,74+,75+,76+,77+,78+,79+,85+,86+,87+,88+/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

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Article
PubMed
n/an/an/a>1.00E+3n/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human PlGF-1


J Med Chem 54: 1256-65 (2011)


Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1
More data for this
Ligand-Target Pair
Placenta growth factor


(Homo sapiens)
BDBM50339207
PNG
(CHEMBL1689476)
Show SMILES CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCNC(C)=O)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCNC(=O)COCC(=O)Nc2ccc(CCC(=O)N3CCC3=O)cc2)NC(C)=O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(C)C)C(N)=O
Show InChI InChI=1S/C98H144N24O26S3/c1-50(2)38-70-98(147)121-35-19-24-73(121)93(142)113-67(40-60-44-101-49-105-60)87(136)115-71(91(140)109-65(23-15-17-33-102-55(10)124)86(135)117-80(51(3)4)94(143)108-63(84(100)133)32-37-149-12)47-150-151-48-72(92(141)111-68(41-74(99)126)88(137)110-66(39-58-43-104-62-21-14-13-20-61(58)62)89(138)119-82(53(7)8)96(145)120-83(54(9)123)97(146)114-70)116-95(144)81(52(5)6)118-90(139)69(42-79(131)132)112-85(134)64(106-56(11)125)22-16-18-34-103-75(127)45-148-46-76(128)107-59-28-25-57(26-29-59)27-30-77(129)122-36-31-78(122)130/h13-14,20-21,25-26,28-29,43-44,49-54,63-73,80-83,104,123H,15-19,22-24,27,30-42,45-48H2,1-12H3,(H2,99,126)(H2,100,133)(H,101,105)(H,102,124)(H,103,127)(H,106,125)(H,107,128)(H,108,143)(H,109,140)(H,110,137)(H,111,141)(H,112,134)(H,113,142)(H,114,146)(H,115,136)(H,116,144)(H,117,135)(H,118,139)(H,119,138)(H,120,145)(H,131,132)/t54-,63+,64+,65+,66+,67+,68+,69+,70+,71+,72+,73+,80+,81+,82+,83+/m1/s1
PDB
MMDB

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KEGG

UniProtKB/SwissProt

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UniChem

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Article
PubMed
n/an/an/a>1.00E+3n/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human PlGF-1


J Med Chem 54: 1256-65 (2011)


Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1
More data for this
Ligand-Target Pair
Placenta growth factor


(Homo sapiens)
BDBM50339191
PNG
(CHEMBL1689460)
Show SMILES CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2ccccc2)NC(C)=O)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NC(=O)COCC(=O)Nc1ccc(CCC(=O)N2CCC2=O)cc1
Show InChI InChI=1S/C107H157N25O25S3/c1-58(2)46-79-107(156)131-43-23-31-82(131)102(151)122-77(49-68-52-111-57-113-68)97(146)124-80(100(149)118-73(30-19-22-42-110)95(144)127-88(59(3)4)103(152)119-74(39-45-158-11)93(142)116-72(29-18-21-41-109)94(143)126-84(136)54-157-53-83(135)115-67-35-32-64(33-36-67)34-37-85(137)132-44-38-86(132)138)55-159-160-56-81(125-104(153)89(60(5)6)128-99(148)78(50-87(139)140)121-96(145)75(114-63(10)134)47-65-24-13-12-14-25-65)101(150)117-71(28-17-20-40-108)92(141)120-76(48-66-51-112-70-27-16-15-26-69(66)70)98(147)129-90(61(7)8)105(154)130-91(62(9)133)106(155)123-79/h12-16,24-27,32-33,35-36,51-52,57-62,71-82,88-91,112,133H,17-23,28-31,34,37-50,53-56,108-110H2,1-11H3,(H,111,113)(H,114,134)(H,115,135)(H,116,142)(H,117,150)(H,118,149)(H,119,152)(H,120,141)(H,121,145)(H,122,151)(H,123,155)(H,124,146)(H,125,153)(H,127,144)(H,128,148)(H,129,147)(H,130,154)(H,139,140)(H,126,136,143)/t62-,71+,72+,73+,74+,75+,76+,77+,78+,79+,80+,81+,82+,88+,89+,90+,91+/m1/s1
PDB
MMDB

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KEGG

UniProtKB/SwissProt

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UniChem

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n/an/a 2n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human PlGF-1-VEGFR-1 interaction by ELISA


J Med Chem 54: 1256-65 (2011)


Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1
More data for this
Ligand-Target Pair
Placenta growth factor


(Homo sapiens)
BDBM50339192
PNG
(CHEMBL1689461)
Show SMILES CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)COCC(=O)Nc2ccc(CCC(=O)N3CCC3=O)cc2)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(C)C)C(N)=O
Show InChI InChI=1S/C99H143N23O23S3/c1-53(2)41-72-99(144)121-38-20-27-75(121)94(139)113-70(44-62-47-103-52-105-62)89(134)115-73(92(137)110-67(26-17-19-37-101)87(132)117-81(54(3)4)95(140)108-65(85(102)130)35-40-146-10)50-147-148-51-74(93(138)109-66(25-16-18-36-100)86(131)111-69(43-60-46-104-64-24-15-14-23-63(60)64)90(135)119-83(56(7)8)97(142)120-84(57(9)123)98(143)114-72)116-96(141)82(55(5)6)118-91(136)71(45-80(128)129)112-88(133)68(42-59-21-12-11-13-22-59)107-77(125)49-145-48-76(124)106-61-31-28-58(29-32-61)30-33-78(126)122-39-34-79(122)127/h11-15,21-24,28-29,31-32,46-47,52-57,65-75,81-84,104,123H,16-20,25-27,30,33-45,48-51,100-101H2,1-10H3,(H2,102,130)(H,103,105)(H,106,124)(H,107,125)(H,108,140)(H,109,138)(H,110,137)(H,111,131)(H,112,133)(H,113,139)(H,114,143)(H,115,134)(H,116,141)(H,117,132)(H,118,136)(H,119,135)(H,120,142)(H,128,129)/t57-,65+,66+,67+,68+,69+,70+,71+,72+,73+,74+,75+,81+,82+,83+,84+/m1/s1
PDB
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n/an/a 1.00E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human PlGF-1-VEGFR-1 interaction by ELISA


J Med Chem 54: 1256-65 (2011)


Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1
More data for this
Ligand-Target Pair
Placenta growth factor


(Homo sapiens)
BDBM50339193
PNG
(CHEMBL1689463)
Show SMILES CSCC[C@H](NC(=O)[C@H](CCCCNC(=O)COCC(=O)Nc1ccc(CCC(=O)N2CCC2=O)cc1)NC(=O)[C@H](CCCCNC(C)=O)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2ccccc2)NC(C)=O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(N)=O
Show InChI InChI=1S/C102H144N24O26S3/c1-54(2)41-75-102(151)125-38-20-27-78(125)98(147)118-72(44-64-48-105-53-109-64)92(141)120-76(96(145)114-69(25-16-18-36-106-58(8)128)90(139)113-68(89(138)112-67(88(104)137)35-40-153-10)26-17-19-37-107-80(131)49-152-50-81(132)111-63-31-28-60(29-32-63)30-33-82(133)126-39-34-83(126)134)51-154-155-52-77(121-99(148)85(55(3)4)122-95(144)74(46-84(135)136)117-91(140)70(110-59(9)129)42-61-21-12-11-13-22-61)97(146)116-73(45-79(103)130)93(142)115-71(43-62-47-108-66-24-15-14-23-65(62)66)94(143)123-86(56(5)6)100(149)124-87(57(7)127)101(150)119-75/h11-15,21-24,28-29,31-32,47-48,53-57,67-78,85-87,108,127H,16-20,25-27,30,33-46,49-52H2,1-10H3,(H2,103,130)(H2,104,137)(H,105,109)(H,106,128)(H,107,131)(H,110,129)(H,111,132)(H,112,138)(H,113,139)(H,114,145)(H,115,142)(H,116,146)(H,117,140)(H,118,147)(H,119,150)(H,120,141)(H,121,148)(H,122,144)(H,123,143)(H,124,149)(H,135,136)/t57-,67+,68+,69+,70+,71+,72+,73+,74+,75+,76+,77+,78+,85+,86+,87+/m1/s1
PDB
MMDB

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n/an/a 4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human PlGF-1-VEGFR-1 interaction by ELISA


J Med Chem 54: 1256-65 (2011)


Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1
More data for this
Ligand-Target Pair
Placenta growth factor


(Mus musculus)
BDBM50339193
PNG
(CHEMBL1689463)
Show SMILES CSCC[C@H](NC(=O)[C@H](CCCCNC(=O)COCC(=O)Nc1ccc(CCC(=O)N2CCC2=O)cc1)NC(=O)[C@H](CCCCNC(C)=O)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2ccccc2)NC(C)=O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(N)=O
Show InChI InChI=1S/C102H144N24O26S3/c1-54(2)41-75-102(151)125-38-20-27-78(125)98(147)118-72(44-64-48-105-53-109-64)92(141)120-76(96(145)114-69(25-16-18-36-106-58(8)128)90(139)113-68(89(138)112-67(88(104)137)35-40-153-10)26-17-19-37-107-80(131)49-152-50-81(132)111-63-31-28-60(29-32-63)30-33-82(133)126-39-34-83(126)134)51-154-155-52-77(121-99(148)85(55(3)4)122-95(144)74(46-84(135)136)117-91(140)70(110-59(9)129)42-61-21-12-11-13-22-61)97(146)116-73(45-79(103)130)93(142)115-71(43-62-47-108-66-24-15-14-23-65(62)66)94(143)123-86(56(5)6)100(149)124-87(57(7)127)101(150)119-75/h11-15,21-24,28-29,31-32,47-48,53-57,67-78,85-87,108,127H,16-20,25-27,30,33-46,49-52H2,1-10H3,(H2,103,130)(H2,104,137)(H,105,109)(H,106,128)(H,107,131)(H,110,129)(H,111,132)(H,112,138)(H,113,139)(H,114,145)(H,115,142)(H,116,146)(H,117,140)(H,118,147)(H,119,150)(H,120,141)(H,121,148)(H,122,144)(H,123,143)(H,124,149)(H,135,136)/t57-,67+,68+,69+,70+,71+,72+,73+,74+,75+,76+,77+,78+,85+,86+,87+/m1/s1
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n/an/a 4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse PlGF-VEGFR-1 interaction by ELISA


J Med Chem 54: 1256-65 (2011)


Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1
More data for this
Ligand-Target Pair
Placenta growth factor


(Mus musculus)
BDBM50339197
PNG
(CHEMBL1689466)
Show SMILES CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCNC(=O)COCC(=O)Nc1ccc(CCC(=O)N2CCC2=O)cc1)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2ccccc2)NC(C)=O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(C)C)C(N)=O
Show InChI InChI=1S/C99H139N23O25S3/c1-51(2)38-71-99(146)121-35-19-25-74(121)94(141)113-68(41-61-45-102-50-105-61)88(135)115-72(92(139)109-65(86(133)117-81(52(3)4)95(142)108-64(85(101)132)33-37-148-11)24-17-18-34-103-76(126)46-147-47-77(127)107-60-29-26-57(27-30-60)28-31-78(128)122-36-32-79(122)129)48-149-150-49-73(116-96(143)82(53(5)6)118-91(138)70(43-80(130)131)112-87(134)66(106-56(10)124)39-58-20-13-12-14-21-58)93(140)111-69(42-75(100)125)89(136)110-67(40-59-44-104-63-23-16-15-22-62(59)63)90(137)119-83(54(7)8)97(144)120-84(55(9)123)98(145)114-71/h12-16,20-23,26-27,29-30,44-45,50-55,64-74,81-84,104,123H,17-19,24-25,28,31-43,46-49H2,1-11H3,(H2,100,125)(H2,101,132)(H,102,105)(H,103,126)(H,106,124)(H,107,127)(H,108,142)(H,109,139)(H,110,136)(H,111,140)(H,112,134)(H,113,141)(H,114,145)(H,115,135)(H,116,143)(H,117,133)(H,118,138)(H,119,137)(H,120,144)(H,130,131)/t55-,64+,65+,66+,67+,68+,69+,70+,71+,72+,73+,74+,81+,82+,83+,84+/m1/s1
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n/an/a 54n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse PlGF-VEGFR-1 interaction by ELISA


J Med Chem 54: 1256-65 (2011)


Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1
More data for this
Ligand-Target Pair
Placenta growth factor


(Mus musculus)
BDBM50339198
PNG
(CHEMBL1689467)
Show SMILES CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCNC(C)=O)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2ccccc2)NC(C)=O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)COCC(=O)Nc2ccc(CCC(=O)N3CCC3=O)cc2)C(=O)N1)C(C)C)C(N)=O
Show InChI InChI=1S/C101H146N22O26S3/c1-53(2)43-73-101(148)122-40-22-29-76(122)96(143)111-67(27-19-21-39-105-78(128)49-149-50-79(129)108-63-33-30-60(31-34-63)32-35-80(130)123-41-36-81(123)131)88(135)116-74(94(141)110-68(28-18-20-38-104-58(10)125)89(136)118-83(54(3)4)97(144)109-66(87(103)134)37-42-150-12)51-151-152-52-75(117-98(145)84(55(5)6)119-93(140)72(47-82(132)133)114-90(137)69(107-59(11)126)44-61-23-14-13-15-24-61)95(142)113-71(46-77(102)127)91(138)112-70(45-62-48-106-65-26-17-16-25-64(62)65)92(139)120-85(56(7)8)99(146)121-86(57(9)124)100(147)115-73/h13-17,23-26,30-31,33-34,48,53-57,66-76,83-86,106,124H,18-22,27-29,32,35-47,49-52H2,1-12H3,(H2,102,127)(H2,103,134)(H,104,125)(H,105,128)(H,107,126)(H,108,129)(H,109,144)(H,110,141)(H,111,143)(H,112,138)(H,113,142)(H,114,137)(H,115,147)(H,116,135)(H,117,145)(H,118,136)(H,119,140)(H,120,139)(H,121,146)(H,132,133)/t57-,66+,67+,68+,69+,70+,71+,72+,73+,74+,75+,76+,83+,84+,85+,86+/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse PlGF-VEGFR-1 interaction by ELISA


J Med Chem 54: 1256-65 (2011)


Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1
More data for this
Ligand-Target Pair
Placenta growth factor


(Mus musculus)
BDBM50339199
PNG
(CHEMBL1689468)
Show SMILES CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCNC(C)=O)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2ccccc2)NC(C)=O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(=O)COCC(=O)Nc2ccc(CCC(=O)N3CCC3=O)cc2)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(C)C)C(N)=O
Show InChI InChI=1S/C102H146N24O26S3/c1-53(2)40-70-91(140)113-68(26-19-21-37-107-79(131)48-152-49-80(132)111-63-31-28-60(29-32-63)30-33-81(133)126-38-34-82(126)134)89(138)116-73(43-64-47-105-52-109-64)93(142)120-76(97(146)114-69(27-18-20-36-106-58(10)128)90(139)122-84(54(3)4)99(148)112-67(88(104)137)35-39-153-12)50-154-155-51-77(121-100(149)85(55(5)6)123-96(145)75(45-83(135)136)118-92(141)71(110-59(11)129)41-61-22-14-13-15-23-61)98(147)117-74(44-78(103)130)94(143)115-72(42-62-46-108-66-25-17-16-24-65(62)66)95(144)124-86(56(7)8)101(150)125-87(57(9)127)102(151)119-70/h13-17,22-25,28-29,31-32,46-47,52-57,67-77,84-87,108,127H,18-21,26-27,30,33-45,48-51H2,1-12H3,(H2,103,130)(H2,104,137)(H,105,109)(H,106,128)(H,107,131)(H,110,129)(H,111,132)(H,112,148)(H,113,140)(H,114,146)(H,115,143)(H,116,138)(H,117,147)(H,118,141)(H,119,151)(H,120,142)(H,121,149)(H,122,139)(H,123,145)(H,124,144)(H,125,150)(H,135,136)/t57-,67+,68+,69+,70+,71+,72+,73+,74+,75+,76+,77+,84+,85+,86+,87+/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse PlGF-VEGFR-1 interaction by ELISA


J Med Chem 54: 1256-65 (2011)


Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1
More data for this
Ligand-Target Pair
Placenta growth factor


(Mus musculus)
BDBM50339200
PNG
(CHEMBL1689469)
Show SMILES CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCNC(C)=O)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2ccccc2)NC(C)=O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCNC(=O)COCC(=O)Nc2ccc(CCC(=O)N3CCC3=O)cc2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(C)C)C(N)=O
Show InChI InChI=1S/C101H142N24O26S3/c1-53(2)83(97(146)111-66(87(103)136)35-40-152-10)120-88(137)67(25-16-18-36-105-57(8)127)112-94(143)74-50-153-154-51-75(119-98(147)84(54(3)4)121-93(142)73(45-82(134)135)116-89(138)69(109-58(9)128)41-60-21-12-11-13-22-60)95(144)115-72(44-77(102)129)91(140)114-70(42-61-46-107-65-24-15-14-23-64(61)65)92(141)122-85(55(5)6)99(148)123-86(56(7)126)100(149)113-68(101(150)124-38-20-27-76(124)96(145)117-71(90(139)118-74)43-63-47-104-52-108-63)26-17-19-37-106-78(130)48-151-49-79(131)110-62-31-28-59(29-32-62)30-33-80(132)125-39-34-81(125)133/h11-15,21-24,28-29,31-32,46-47,52-56,66-76,83-86,107,126H,16-20,25-27,30,33-45,48-51H2,1-10H3,(H2,102,129)(H2,103,136)(H,104,108)(H,105,127)(H,106,130)(H,109,128)(H,110,131)(H,111,146)(H,112,143)(H,113,149)(H,114,140)(H,115,144)(H,116,138)(H,117,145)(H,118,139)(H,119,147)(H,120,137)(H,121,142)(H,122,141)(H,123,148)(H,134,135)/t56-,66+,67+,68+,69+,70+,71+,72+,73+,74+,75+,76+,83+,84+,85+,86+/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse PlGF-VEGFR-1 interaction by ELISA


J Med Chem 54: 1256-65 (2011)


Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1
More data for this
Ligand-Target Pair
Placenta growth factor


(Mus musculus)
BDBM50339201
PNG
(CHEMBL1689470)
Show SMILES CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCNC(C)=O)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2ccccc2)NC(C)=O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCNC(=O)COCC(=O)Nc2ccc(CCC(=O)N3CCC3=O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(C)C)C(N)=O
Show InChI InChI=1S/C103H146N24O25S3/c1-55(2)42-76-103(151)126-39-21-28-79(126)99(147)119-73(45-65-49-106-54-110-65)93(141)121-77(97(145)114-70(27-17-19-37-107-59(9)128)91(139)123-86(56(3)4)100(148)113-68(89(105)137)36-41-153-11)52-154-155-53-78(122-102(150)88(58(7)8)125-96(144)75(47-85(135)136)118-92(140)71(111-60(10)129)43-62-22-13-12-14-23-62)98(146)117-74(46-80(104)130)94(142)116-72(44-63-48-109-67-25-16-15-24-66(63)67)95(143)124-87(57(5)6)101(149)115-69(90(138)120-76)26-18-20-38-108-81(131)50-152-51-82(132)112-64-32-29-61(30-33-64)31-34-83(133)127-40-35-84(127)134/h12-16,22-25,29-30,32-33,48-49,54-58,68-79,86-88,109H,17-21,26-28,31,34-47,50-53H2,1-11H3,(H2,104,130)(H2,105,137)(H,106,110)(H,107,128)(H,108,131)(H,111,129)(H,112,132)(H,113,148)(H,114,145)(H,115,149)(H,116,142)(H,117,146)(H,118,140)(H,119,147)(H,120,138)(H,121,141)(H,122,150)(H,123,139)(H,124,143)(H,125,144)(H,135,136)/t68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,86-,87-,88-/m0/s1
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n/an/a 4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse PlGF-VEGFR-1 interaction by ELISA


J Med Chem 54: 1256-65 (2011)


Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1
More data for this
Ligand-Target Pair
Placenta growth factor


(Mus musculus)
BDBM50339202
PNG
(CHEMBL1689471)
Show SMILES CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCNC(C)=O)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2ccccc2)NC(C)=O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CCCCNC(=O)COCC(=O)Nc2ccc(CCC(=O)N3CCC3=O)cc2)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(C)C)C(N)=O
Show InChI InChI=1S/C102H144N24O26S3/c1-54(2)41-75-102(151)125-38-20-27-78(125)98(147)118-72(44-64-48-105-53-109-64)93(142)120-76(96(145)114-68(25-16-18-36-106-58(8)128)89(138)122-85(55(3)4)99(148)112-67(88(104)137)35-40-153-10)51-154-155-52-77(121-100(149)86(56(5)6)123-95(144)74(46-84(135)136)117-91(140)70(110-59(9)129)42-61-21-12-11-13-22-61)97(146)116-73(45-79(103)130)94(143)115-71(43-62-47-108-66-24-15-14-23-65(62)66)92(141)113-69(90(139)124-87(57(7)127)101(150)119-75)26-17-19-37-107-80(131)49-152-50-81(132)111-63-31-28-60(29-32-63)30-33-82(133)126-39-34-83(126)134/h11-15,21-24,28-29,31-32,47-48,53-57,67-78,85-87,108,127H,16-20,25-27,30,33-46,49-52H2,1-10H3,(H2,103,130)(H2,104,137)(H,105,109)(H,106,128)(H,107,131)(H,110,129)(H,111,132)(H,112,148)(H,113,141)(H,114,145)(H,115,143)(H,116,146)(H,117,140)(H,118,147)(H,119,150)(H,120,142)(H,121,149)(H,122,138)(H,123,144)(H,124,139)(H,135,136)/t57-,67+,68+,69+,70+,71+,72+,73+,74+,75+,76+,77+,78+,85+,86+,87+/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse PlGF-VEGFR-1 interaction by ELISA


J Med Chem 54: 1256-65 (2011)


Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1
More data for this
Ligand-Target Pair
Placenta growth factor


(Mus musculus)
BDBM50339203
PNG
(CHEMBL1689472)
Show SMILES CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCNC(C)=O)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2ccccc2)NC(C)=O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCNC(=O)COCC(=O)Nc2ccc(CCC(=O)N3CCC3=O)cc2)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(C)C)C(N)=O
Show InChI InChI=1S/C96H143N23O26S3/c1-50(2)39-68-96(144)118-36-20-25-71(118)91(139)110-65(41-60-44-99-49-102-60)86(134)112-69(89(137)107-63(23-16-18-34-100-55(10)121)84(132)114-78(51(3)4)92(140)105-61(82(98)130)33-38-146-12)47-147-148-48-70(113-93(141)79(52(5)6)116-88(136)67(43-77(128)129)109-85(133)64(103-56(11)122)40-58-21-14-13-15-22-58)90(138)108-66(42-72(97)123)87(135)106-62(83(131)115-80(53(7)8)94(142)117-81(54(9)120)95(143)111-68)24-17-19-35-101-73(124)45-145-46-74(125)104-59-29-26-57(27-30-59)28-31-75(126)119-37-32-76(119)127/h13-15,21-22,26-27,29-30,44,49-54,61-71,78-81,120H,16-20,23-25,28,31-43,45-48H2,1-12H3,(H2,97,123)(H2,98,130)(H,99,102)(H,100,121)(H,101,124)(H,103,122)(H,104,125)(H,105,140)(H,106,135)(H,107,137)(H,108,138)(H,109,133)(H,110,139)(H,111,143)(H,112,134)(H,113,141)(H,114,132)(H,115,131)(H,116,136)(H,117,142)(H,128,129)/t54-,61+,62+,63+,64+,65+,66+,67+,68+,69+,70+,71+,78+,79+,80+,81+/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse PlGF-VEGFR-1 interaction by ELISA


J Med Chem 54: 1256-65 (2011)


Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1
More data for this
Ligand-Target Pair
Placenta growth factor


(Mus musculus)
BDBM50339204
PNG
(CHEMBL1689473)
Show SMILES CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCNC(C)=O)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2ccccc2)NC(C)=O)C(C)C)C(=O)N[C@@H](CCCCNC(=O)COCC(=O)Nc2ccc(CCC(=O)N3CCC3=O)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(C)C)C(N)=O
Show InChI InChI=1S/C103H147N23O25S3/c1-55(2)43-76-103(150)125-40-22-29-79(125)98(145)117-74(46-66-49-105-54-109-66)93(140)119-77(96(143)114-71(28-18-20-38-106-60(10)128)91(138)121-85(56(3)4)99(146)112-69(89(104)136)37-42-152-12)52-153-154-53-78(120-100(147)86(57(5)6)122-95(142)75(47-84(134)135)116-92(139)72(110-61(11)129)44-63-23-14-13-15-24-63)97(144)113-70(27-19-21-39-107-80(130)50-151-51-81(131)111-65-33-30-62(31-34-65)32-35-82(132)126-41-36-83(126)133)90(137)115-73(45-64-48-108-68-26-17-16-25-67(64)68)94(141)123-87(58(7)8)101(148)124-88(59(9)127)102(149)118-76/h13-17,23-26,30-31,33-34,48-49,54-59,69-79,85-88,108,127H,18-22,27-29,32,35-47,50-53H2,1-12H3,(H2,104,136)(H,105,109)(H,106,128)(H,107,130)(H,110,129)(H,111,131)(H,112,146)(H,113,144)(H,114,143)(H,115,137)(H,116,139)(H,117,145)(H,118,149)(H,119,140)(H,120,147)(H,121,138)(H,122,142)(H,123,141)(H,124,148)(H,134,135)/t59-,69+,70+,71+,72+,73+,74+,75+,76+,77+,78+,79+,85+,86+,87+,88+/m1/s1
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n/an/a 624n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse PlGF-VEGFR-1 interaction by ELISA


J Med Chem 54: 1256-65 (2011)


Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1
More data for this
Ligand-Target Pair
Placenta growth factor


(Mus musculus)
BDBM50339205
PNG
(CHEMBL1689474)
Show SMILES CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCNC(C)=O)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](CCCCNC(=O)COCC(=O)Nc2ccc(CCC(=O)N3CCC3=O)cc2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2ccccc2)NC(C)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(C)C)C(N)=O
Show InChI InChI=1S/C102H144N24O26S3/c1-54(2)41-75-102(151)125-38-20-27-78(125)98(147)118-72(44-64-48-105-53-109-64)92(141)121-76(96(145)114-69(26-16-18-36-106-58(8)128)90(139)122-85(55(3)4)99(148)112-67(88(104)137)35-40-153-10)51-154-155-52-77(97(146)116-73(45-79(103)130)93(142)115-71(43-62-47-108-66-24-15-14-23-65(62)66)95(144)123-86(56(5)6)100(149)124-87(57(7)127)101(150)119-75)120-89(138)68(113-94(143)74(46-84(135)136)117-91(140)70(110-59(9)129)42-61-21-12-11-13-22-61)25-17-19-37-107-80(131)49-152-50-81(132)111-63-31-28-60(29-32-63)30-33-82(133)126-39-34-83(126)134/h11-15,21-24,28-29,31-32,47-48,53-57,67-78,85-87,108,127H,16-20,25-27,30,33-46,49-52H2,1-10H3,(H2,103,130)(H2,104,137)(H,105,109)(H,106,128)(H,107,131)(H,110,129)(H,111,132)(H,112,148)(H,113,143)(H,114,145)(H,115,142)(H,116,146)(H,117,140)(H,118,147)(H,119,150)(H,120,138)(H,121,141)(H,122,139)(H,123,144)(H,124,149)(H,135,136)/t57-,67+,68+,69+,70+,71+,72+,73+,74+,75+,76+,77+,78+,85+,86+,87+/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse PlGF-VEGFR-1 interaction by ELISA


J Med Chem 54: 1256-65 (2011)


Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1
More data for this
Ligand-Target Pair
Placenta growth factor


(Mus musculus)
BDBM50339213
PNG
(CHEMBL1689478)
Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC1=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc1ccccc1)NC(C)=O)C(C)C
Show InChI InChI=1S/C90H130N26O21S2/c1-9-48(6)72-86(135)104-59(19-14-32-99-90(94)95)76(125)110-66(34-46(2)3)88(137)116-33-15-20-69(116)84(133)109-65(39-55-41-97-45-101-55)80(129)111-68(83(132)115-73(49(7)117)87(136)105-58(18-13-31-98-89(92)93)75(124)106-61(74(91)123)35-52-21-25-56(119)26-22-52)43-139-138-42-67(82(131)108-64(38-54-40-96-44-100-54)79(128)107-63(81(130)114-72)37-53-23-27-57(120)28-24-53)112-85(134)71(47(4)5)113-77(126)60(29-30-70(121)122)103-78(127)62(102-50(8)118)36-51-16-11-10-12-17-51/h10-12,16-17,21-28,40-41,44-49,58-69,71-73,117,119-120H,9,13-15,18-20,29-39,42-43H2,1-8H3,(H2,91,123)(H,96,100)(H,97,101)(H,102,118)(H,103,127)(H,104,135)(H,105,136)(H,106,124)(H,107,128)(H,108,131)(H,109,133)(H,110,125)(H,111,129)(H,112,134)(H,113,126)(H,114,130)(H,115,132)(H,121,122)(H4,92,93,98)(H4,94,95,99)/t48-,49+,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,71-,72-,73-/m0/s1
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n/an/a 400n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse PlGF-VEGFR-1 interaction by ELISA


J Med Chem 54: 1256-65 (2011)


Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1
More data for this
Ligand-Target Pair
Placenta growth factor


(Mus musculus)
BDBM50339209
PNG
(CHEMBL1689479)
Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCNC(=O)COCC(=O)Nc2ccc(CCC(=O)N3CCC3=O)cc2)NC1=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc1ccccc1)NC(C)=O)C(C)C
Show InChI InChI=1S/C106H146N26O26S2/c1-9-59(6)89-103(155)119-71(19-13-14-39-112-83(137)51-158-52-84(138)117-66-29-22-62(23-30-66)28-36-85(139)132-42-38-86(132)140)93(145)125-79(43-57(2)3)105(157)131-41-16-21-82(131)101(153)124-78(48-68-50-111-56-115-68)97(149)126-81(100(152)130-90(60(7)133)104(156)120-72(20-15-40-113-106(108)109)92(144)121-74(91(107)143)44-64-24-31-69(135)32-25-64)54-160-159-53-80(99(151)123-77(47-67-49-110-55-114-67)96(148)122-76(98(150)129-89)46-65-26-33-70(136)34-27-65)127-102(154)88(58(4)5)128-94(146)73(35-37-87(141)142)118-95(147)75(116-61(8)134)45-63-17-11-10-12-18-63/h10-12,17-18,22-27,29-34,49-50,55-60,71-82,88-90,133,135-136H,9,13-16,19-21,28,35-48,51-54H2,1-8H3,(H2,107,143)(H,110,114)(H,111,115)(H,112,137)(H,116,134)(H,117,138)(H,118,147)(H,119,155)(H,120,156)(H,121,144)(H,122,148)(H,123,151)(H,124,153)(H,125,145)(H,126,149)(H,127,154)(H,128,146)(H,129,150)(H,130,152)(H,141,142)(H4,108,109,113)/t59-,60+,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,88-,89-,90-/m0/s1
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n/an/a 0.700n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse PlGF-VEGFR-1 interaction by ELISA


J Med Chem 54: 1256-65 (2011)


Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1
More data for this
Ligand-Target Pair
Placenta growth factor


(Mus musculus)
BDBM50339214
PNG
(CHEMBL1689480)
Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCNC(=O)COCC(=O)Nc2ccc(CCC(=O)N3CCC3=O)cc2)NC1=O)C(=O)N[C@H]([C@@H](C)O)C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@H](Cc1ccc(O)cc1)C(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc1ccccc1)NC(C)=O)C(C)C
Show InChI InChI=1S/C106H146N26O26S2/c1-9-59(6)89-103(155)119-71(19-13-14-39-112-83(137)51-158-52-84(138)117-66-29-22-62(23-30-66)28-36-85(139)132-42-38-86(132)140)93(145)125-79(43-57(2)3)105(157)131-41-16-21-82(131)101(153)124-78(48-68-50-111-56-115-68)97(149)126-81(100(152)130-90(60(7)133)104(156)120-72(20-15-40-113-106(108)109)92(144)121-74(91(107)143)44-64-24-31-69(135)32-25-64)54-160-159-53-80(99(151)123-77(47-67-49-110-55-114-67)96(148)122-76(98(150)129-89)46-65-26-33-70(136)34-27-65)127-102(154)88(58(4)5)128-94(146)73(35-37-87(141)142)118-95(147)75(116-61(8)134)45-63-17-11-10-12-18-63/h10-12,17-18,22-27,29-34,49-50,55-60,71-82,88-90,133,135-136H,9,13-16,19-21,28,35-48,51-54H2,1-8H3,(H2,107,143)(H,110,114)(H,111,115)(H,112,137)(H,116,134)(H,117,138)(H,118,147)(H,119,155)(H,120,156)(H,121,144)(H,122,148)(H,123,151)(H,124,153)(H,125,145)(H,126,149)(H,127,154)(H,128,146)(H,129,150)(H,130,152)(H,141,142)(H4,108,109,113)/t59-,60+,71-,72+,73-,74+,75-,76-,77-,78-,79-,80-,81-,82-,88-,89-,90+/m0/s1
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UniProtKB/SwissProt

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UniChem

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PubMed
n/an/a 0.200n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse PlGF-VEGFR-1 interaction by ELISA


J Med Chem 54: 1256-65 (2011)


Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1
More data for this
Ligand-Target Pair
Placenta growth factor


(Homo sapiens)
BDBM50339210
PNG
(CHEMBL1689481)
Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCNC(=O)COCC(=O)Nc2ccc(CCC(=O)N3CCC3=O)cc2)NC1=O)C(=O)N[C@H]([C@@H](C)O)C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@H](Cc1ccc(O)cc1)C(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(C)=O)C(C)C
Show InChI InChI=1S/C116H161N29O31S2/c1-11-62(6)96-113(173)131-76(21-15-16-41-122-89(150)54-176-55-90(151)129-71-31-24-67(25-32-71)30-38-91(152)145-44-40-92(145)153)102(162)138-85(45-60(2)3)115(175)144-43-18-23-88(144)111(171)137-83(50-73-53-121-59-125-73)107(167)139-87(110(170)143-97(65(9)146)114(174)132-77(22-17-42-123-116(118)119)101(161)133-79(98(117)158)46-69-26-33-74(148)34-27-69)57-178-177-56-86(109(169)136-82(49-72-52-120-58-124-72)106(166)135-81(108(168)142-96)48-70-28-35-75(149)36-29-70)140-112(172)95(61(4)5)141-103(163)78(37-39-93(154)155)130-105(165)80(47-68-19-13-12-14-20-68)134-100(160)64(8)126-99(159)63(7)127-104(164)84(51-94(156)157)128-66(10)147/h12-14,19-20,24-29,31-36,52-53,58-65,76-88,95-97,146,148-149H,11,15-18,21-23,30,37-51,54-57H2,1-10H3,(H2,117,158)(H,120,124)(H,121,125)(H,122,150)(H,126,159)(H,127,164)(H,128,147)(H,129,151)(H,130,165)(H,131,173)(H,132,174)(H,133,161)(H,134,160)(H,135,166)(H,136,169)(H,137,171)(H,138,162)(H,139,167)(H,140,172)(H,141,163)(H,142,168)(H,143,170)(H,154,155)(H,156,157)(H4,118,119,123)/t62-,63-,64-,65+,76-,77+,78-,79+,80-,81-,82-,83-,84-,85-,86-,87-,88-,95-,96-,97+/m0/s1
PDB
MMDB

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KEGG

UniProtKB/SwissProt

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UniChem

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n/an/a 1n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human PlGF-1-VEGFR-1 interaction by ELISA


J Med Chem 54: 1256-65 (2011)


Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1
More data for this
Ligand-Target Pair
Placenta growth factor


(Homo sapiens)
BDBM50339211
PNG
(CHEMBL1689482)
Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCNC(=O)COCC(=O)Nc2ccc(CCC(=O)N3CCC3=O)cc2)NC1=O)C(=O)N[C@H]([C@@H](C)O)C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@H](Cc1ccc(O)cc1)C(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(C)=O)C(C)C
Show InChI InChI=1S/C120H168N30O32S2/c1-13-64(6)99-116(178)134-79(23-17-18-43-126-92(155)56-182-57-93(156)133-74-33-26-70(27-34-74)32-40-94(157)150-46-42-95(150)158)106(168)142-86(47-62(2)3)119(181)149-45-20-25-91(149)114(176)140-84(52-76-55-125-61-129-76)109(171)143-89(112(174)147-100(68(10)151)117(179)135-80(24-19-44-127-120(122)123)105(167)136-81(101(121)163)48-72-28-35-77(153)36-29-72)59-184-183-58-88(111(173)139-83(51-75-54-124-60-128-75)108(170)138-82(110(172)146-99)49-73-30-37-78(154)38-31-73)144-115(177)98(63(4)5)145-113(175)90(39-41-96(159)160)148(12)118(180)87(50-71-21-15-14-16-22-71)141-104(166)67(9)131-102(164)66(8)132-107(169)85(53-97(161)162)137-103(165)65(7)130-69(11)152/h14-16,21-22,26-31,33-38,54-55,60-68,79-91,98-100,151,153-154H,13,17-20,23-25,32,39-53,56-59H2,1-12H3,(H2,121,163)(H,124,128)(H,125,129)(H,126,155)(H,130,152)(H,131,164)(H,132,169)(H,133,156)(H,134,178)(H,135,179)(H,136,167)(H,137,165)(H,138,170)(H,139,173)(H,140,176)(H,141,166)(H,142,168)(H,143,171)(H,144,177)(H,145,175)(H,146,172)(H,147,174)(H,159,160)(H,161,162)(H4,122,123,127)/t64-,65-,66-,67-,68+,79-,80+,81+,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,98-,99-,100+/m0/s1
PDB
MMDB

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UniProtKB/SwissProt

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UniChem

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n/an/a 3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human PlGF-1-VEGFR-1 interaction by ELISA


J Med Chem 54: 1256-65 (2011)


Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1
More data for this
Ligand-Target Pair
Placenta growth factor


(Homo sapiens)
BDBM50339212
PNG
(CHEMBL1689483)
Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@@H](Cc2cnc[nH]2)NC(=O)C(C)(C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCNC(=O)COCC(=O)Nc2ccc(CCC(=O)N3CCC3=O)cc2)NC1=O)C(=O)N[C@H]([C@@H](C)O)C(=O)N[C@@H](CCCCNC(C)=O)C(=O)NC(C)(C)C(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(C)=O)C(C)C
Show InChI InChI=1S/C116H168N28O32S2/c1-18-62(6)94-110(171)128-76(28-23-25-44-121-87(149)54-176-55-88(150)127-72-35-30-69(31-36-72)34-40-89(151)144-45-42-90(144)152)99(160)131-78(46-60(2)3)107(168)142-116(15,16)114(175)137-81(50-74-53-119-59-123-74)102(163)135-85(105(166)140-95(66(10)145)111(172)129-77(29-22-24-43-120-67(11)146)106(167)141-115(13,14)113(117)174)57-178-177-56-84(104(165)133-80(49-73-52-118-58-122-73)101(162)132-79(103(164)139-94)47-71-32-37-75(148)38-33-71)136-109(170)93(61(4)5)138-108(169)86(39-41-91(153)154)143(17)112(173)83(48-70-26-20-19-21-27-70)134-98(159)65(9)125-96(157)64(8)126-100(161)82(51-92(155)156)130-97(158)63(7)124-68(12)147/h19-21,26-27,30-33,35-38,52-53,58-66,76-86,93-95,145,148H,18,22-25,28-29,34,39-51,54-57H2,1-17H3,(H2,117,174)(H,118,122)(H,119,123)(H,120,146)(H,121,149)(H,124,147)(H,125,157)(H,126,161)(H,127,150)(H,128,171)(H,129,172)(H,130,158)(H,131,160)(H,132,162)(H,133,165)(H,134,159)(H,135,163)(H,136,170)(H,137,175)(H,138,169)(H,139,164)(H,140,166)(H,141,167)(H,142,168)(H,153,154)(H,155,156)/t62-,63-,64-,65-,66+,76-,77-,78-,79-,80-,81?,82-,83-,84-,85-,86-,93-,94-,95+/m0/s1
PDB
MMDB

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UniProtKB/SwissProt

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UniChem

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n/an/a 0.400n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human PlGF-1-VEGFR-1 interaction by ELISA


J Med Chem 54: 1256-65 (2011)


Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1
More data for this
Ligand-Target Pair
Placenta growth factor


(Homo sapiens)
BDBM50339191
PNG
(CHEMBL1689460)
Show SMILES CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2ccccc2)NC(C)=O)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NC(=O)COCC(=O)Nc1ccc(CCC(=O)N2CCC2=O)cc1
Show InChI InChI=1S/C107H157N25O25S3/c1-58(2)46-79-107(156)131-43-23-31-82(131)102(151)122-77(49-68-52-111-57-113-68)97(146)124-80(100(149)118-73(30-19-22-42-110)95(144)127-88(59(3)4)103(152)119-74(39-45-158-11)93(142)116-72(29-18-21-41-109)94(143)126-84(136)54-157-53-83(135)115-67-35-32-64(33-36-67)34-37-85(137)132-44-38-86(132)138)55-159-160-56-81(125-104(153)89(60(5)6)128-99(148)78(50-87(139)140)121-96(145)75(114-63(10)134)47-65-24-13-12-14-25-65)101(150)117-71(28-17-20-40-108)92(141)120-76(48-66-51-112-70-27-16-15-26-69(66)70)98(147)129-90(61(7)8)105(154)130-91(62(9)133)106(155)123-79/h12-16,24-27,32-33,35-36,51-52,57-62,71-82,88-91,112,133H,17-23,28-31,34,37-50,53-56,108-110H2,1-11H3,(H,111,113)(H,114,134)(H,115,135)(H,116,142)(H,117,150)(H,118,149)(H,119,152)(H,120,141)(H,121,145)(H,122,151)(H,123,155)(H,124,146)(H,125,153)(H,127,144)(H,128,148)(H,129,147)(H,130,154)(H,139,140)(H,126,136,143)/t62-,71+,72+,73+,74+,75+,76+,77+,78+,79+,80+,81+,82+,88+,89+,90+,91+/m1/s1
PDB
MMDB

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UniProtKB/SwissProt

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UniChem

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n/an/a 150n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human PlGF-2-VEGFR-1 interaction by ELISA


J Med Chem 54: 1256-65 (2011)


Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1
More data for this
Ligand-Target Pair
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