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Compile Data Set for Download or QSAR

Found 1011 hits Enz. Inhib. hit(s) with Target = 'Prostanoid EP1 Receptor'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Prostaglandin E2 receptor EP1 subtype (EP1)


(Homo sapiens (Human))
BDBM50197898
PNG
(6-(2-(2-(2,4-difluorobenzyloxy)-5-chlorophenyl)cyc...)
Show SMILES OC(=O)c1cccc(n1)C1=C(CCC1)c1cc(Cl)ccc1OCc1ccc(F)cc1F
Show InChI InChI=1S/C24H18ClF2NO3/c25-15-8-10-23(31-13-14-7-9-16(26)12-20(14)27)19(11-15)17-3-1-4-18(17)21-5-2-6-22(28-21)24(29)30/h2,5-12H,1,3-4,13H2,(H,29,30)
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n/an/an/a 0.794n/an/an/an/an/a



GSK

Curated by ChEMBL


Assay Description
Antagonist activity at human EP1 receptor


Bioorg Med Chem Lett 17: 385-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.041
BindingDB Entry DOI: 10.7270/Q22J6BGF
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (EP1)


(Homo sapiens (Human))
BDBM50411561
PNG
(CHEMBL234399)
Show SMILES CCc1ccccc1N(CC(=O)NCCc1ccc(OC)c(OC)c1)S(=O)(=O)c1ccc(C)cc1
Show InChI InChI=1S/C27H32N2O5S/c1-5-22-8-6-7-9-24(22)29(35(31,32)23-13-10-20(2)11-14-23)19-27(30)28-17-16-21-12-15-25(33-3)26(18-21)34-4/h6-15,18H,5,16-17,19H2,1-4H3,(H,28,30)
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n/an/an/a 5.01n/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human EP1 receptor expressed in CHO cells receptor by NFTA reporter gene assay


Bioorg Med Chem Lett 17: 1750-4 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.060
BindingDB Entry DOI: 10.7270/Q2SB470M
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (EP1)


(Homo sapiens (Human))
BDBM85599
PNG
(CAS_146032-79-3 | SC-51322)
Show SMILES Clc1ccc2Oc3ccccc3CN(C(=O)NNC(=O)CCSCc3ccco3)c2c1
Show InChI InChI=1S/C22H20ClN3O4S/c23-16-7-8-20-18(12-16)26(13-15-4-1-2-6-19(15)30-20)22(28)25-24-21(27)9-11-31-14-17-5-3-10-29-17/h1-8,10,12H,9,11,13-14H2,(H,24,27)(H,25,28)
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n/an/an/a 7.94n/an/an/an/an/a



Searle

Curated by ChEMBL


Assay Description
PGE-2 (EP1 subtype) antagonistic activity as PGE2-stimulated guinea pig ileum muscle strip assay


J Med Chem 39: 609-13 (1996)


Article DOI: 10.1021/jm950454k
BindingDB Entry DOI: 10.7270/Q21R6RQ9
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (EP1)


(Homo sapiens (Human))
BDBM50259611
PNG
(CHEMBL467114 | sodium 6-(5-chloro-2-(4-chloro-2-fl...)
Show SMILES [O-]C(=O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1
Show InChI InChI=1S/C20H14Cl2FNO3/c21-14-6-7-19(27-11-12-4-5-15(22)10-17(12)23)13(8-14)9-16-2-1-3-18(24-16)20(25)26/h1-8,10H,9,11H2,(H,25,26)/p-1
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n/an/an/a 7.94n/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant EP1 receptor expressed in CHO cells assessed as luciferase activity by Schild assay


Bioorg Med Chem Lett 19: 2599-603 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.112
BindingDB Entry DOI: 10.7270/Q2HT2P68
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (EP1)


(Homo sapiens (Human))
BDBM50373357
PNG
(CHEMBL256092)
Show SMILES CC(C)OC(=O)Nc1cc(C)n(Cc2cc(Cl)ccc2OCc2ccccc2)n1
Show InChI InChI=1S/C22H24ClN3O3/c1-15(2)29-22(27)24-21-11-16(3)26(25-21)13-18-12-19(23)9-10-20(18)28-14-17-7-5-4-6-8-17/h4-12,15H,13-14H2,1-3H3,(H,24,25,27)
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n/an/an/a 7.94n/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at PGE2-EP1 receptor assessed as PGE2-induced response by schild analysis


Bioorg Med Chem Lett 18: 3392-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.018
BindingDB Entry DOI: 10.7270/Q2NK3FV3
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (EP1)


(Homo sapiens (Human))
BDBM50407970
PNG
(CHEMBL345797)
Show SMILES OC(c1ccccn1)C(F)(F)C(=O)NNC(=O)N1Cc2ccccc2Oc2ccc(Cl)cc12
Show InChI InChI=1S/C22H17ClF2N4O4/c23-14-8-9-18-16(11-14)29(12-13-5-1-2-7-17(13)33-18)21(32)28-27-20(31)22(24,25)19(30)15-6-3-4-10-26-15/h1-11,19,30H,12H2,(H,27,31)(H,28,32)
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n/an/an/a 31.6n/an/an/an/an/a



Searle

Curated by ChEMBL


Assay Description
PGE-2 (EP1 subtype) antagonistic activity as PGE2-stimulated guinea pig ileum muscle strip assay


J Med Chem 39: 609-13 (1996)


Article DOI: 10.1021/jm950454k
BindingDB Entry DOI: 10.7270/Q21R6RQ9
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (EP1)


(Homo sapiens (Human))
BDBM50407965
PNG
(CHEMBL436218)
Show SMILES Clc1ccc2Oc3ccccc3CN(C(=O)CNC(=O)CCSCc3ccco3)c2c1
Show InChI InChI=1S/C23H21ClN2O4S/c24-17-7-8-21-19(12-17)26(14-16-4-1-2-6-20(16)30-21)23(28)13-25-22(27)9-11-31-15-18-5-3-10-29-18/h1-8,10,12H,9,11,13-15H2,(H,25,27)
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n/an/an/a 39.8n/an/an/an/an/a



Searle

Curated by ChEMBL


Assay Description
PGE-2 (EP1 subtype) antagonistic activity as PGE2-stimulated guinea pig ileum muscle strip assay


J Med Chem 39: 609-13 (1996)


Article DOI: 10.1021/jm950454k
BindingDB Entry DOI: 10.7270/Q21R6RQ9
More data for this
Ligand-Target Pair
Prostanoid EP1 Receptor


(Mus musculus (Mouse))
BDBM50424384
PNG
(CHEMBL2315055)
Show SMILES Fc1cc(Cl)ccc1COc1ccc(Cl)cc1Cc1cccc(n1)C(=O)NS(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C26H18Cl3FN2O4S/c27-18-6-9-22(10-7-18)37(34,35)32-26(33)24-3-1-2-21(31-24)13-17-12-19(28)8-11-25(17)36-15-16-4-5-20(29)14-23(16)30/h1-12,14H,13,15H2,(H,32,33)
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n/an/an/a 41n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Antagonist activity at mouse EP1 receptor expressed in CHOK1 cells assessed as inhibition of 17PTPGE2-induced calcium influx


Bioorg Med Chem Lett 23: 37-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.11.046
BindingDB Entry DOI: 10.7270/Q2WD41WD
More data for this
Ligand-Target Pair
Prostanoid EP1 Receptor


(Mus musculus (Mouse))
BDBM50424394
PNG
(CHEMBL1207972)
Show SMILES OC(=O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1
Show InChI InChI=1S/C20H14Cl2FNO3/c21-14-6-7-19(27-11-12-4-5-15(22)10-17(12)23)13(8-14)9-16-2-1-3-18(24-16)20(25)26/h1-8,10H,9,11H2,(H,25,26)
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n/an/an/a 48n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Antagonist activity at mouse EP1 receptor expressed in CHOK1 cells assessed as inhibition of 17PTPGE2-induced calcium influx


Bioorg Med Chem Lett 23: 37-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.11.046
BindingDB Entry DOI: 10.7270/Q2WD41WD
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (EP1)


(Homo sapiens (Human))
BDBM50373358
PNG
(CHEMBL258199)
Show SMILES Cc1cc(NC(=O)OC(C)(C)C)nn1Cc1cc(Cl)ccc1OCc1ccccc1
Show InChI InChI=1S/C23H26ClN3O3/c1-16-12-21(25-22(28)30-23(2,3)4)26-27(16)14-18-13-19(24)10-11-20(18)29-15-17-8-6-5-7-9-17/h5-13H,14-15H2,1-4H3,(H,25,26,28)
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n/an/an/a 50.1n/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at PGE2-EP1 receptor assessed as PGE2-induced response by schild analysis


Bioorg Med Chem Lett 18: 3392-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.018
BindingDB Entry DOI: 10.7270/Q2NK3FV3
More data for this
Ligand-Target Pair
Prostanoid EP1 Receptor


(Mus musculus (Mouse))
BDBM50424383
PNG
(CHEMBL2315056)
Show SMILES Fc1cc(Cl)ccc1COc1ccc(Cl)cc1Cc1cccc(n1)C(=O)NS(=O)(=O)c1cc(Cl)ccc1Cl
Show InChI InChI=1S/C26H17Cl4FN2O4S/c27-17-7-9-24(37-14-15-4-5-18(28)12-22(15)31)16(10-17)11-20-2-1-3-23(32-20)26(34)33-38(35,36)25-13-19(29)6-8-21(25)30/h1-10,12-13H,11,14H2,(H,33,34)
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n/an/an/a 54n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Antagonist activity at mouse EP1 receptor expressed in CHOK1 cells assessed as inhibition of 17PTPGE2-induced calcium influx


Bioorg Med Chem Lett 23: 37-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.11.046
BindingDB Entry DOI: 10.7270/Q2WD41WD
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (EP1)


(Homo sapiens (Human))
BDBM50407967
PNG
(CHEMBL352251)
Show SMILES Clc1ccc2Oc3ccccc3CN(C(=O)NCC(=O)CCSCc3ccco3)c2c1
Show InChI InChI=1S/C23H21ClN2O4S/c24-17-7-8-22-20(12-17)26(14-16-4-1-2-6-21(16)30-22)23(28)25-13-18(27)9-11-31-15-19-5-3-10-29-19/h1-8,10,12H,9,11,13-15H2,(H,25,28)
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n/an/an/a 63.1n/an/an/an/an/a



Searle

Curated by ChEMBL


Assay Description
PGE-2 (EP1 subtype) antagonistic activity as PGE2-stimulated guinea pig ileum muscle strip assay


J Med Chem 39: 609-13 (1996)


Article DOI: 10.1021/jm950454k
BindingDB Entry DOI: 10.7270/Q21R6RQ9
More data for this
Ligand-Target Pair
Prostanoid EP1 Receptor


(Mus musculus (Mouse))
BDBM50424381
PNG
(CHEMBL2315059)
Show SMILES Fc1cc(Cl)ccc1COc1ccc(Cl)cc1Cc1cccc(n1)C(=O)NS(=O)(=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C26H17Cl4FN2O4S/c27-17-6-9-25(37-14-15-4-5-18(28)12-23(15)31)16(10-17)11-19-2-1-3-24(32-19)26(34)33-38(35,36)20-7-8-21(29)22(30)13-20/h1-10,12-13H,11,14H2,(H,33,34)
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n/an/an/a 214n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Antagonist activity at mouse EP1 receptor expressed in CHOK1 cells assessed as inhibition of 17PTPGE2-induced calcium influx


Bioorg Med Chem Lett 23: 37-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.11.046
BindingDB Entry DOI: 10.7270/Q2WD41WD
More data for this
Ligand-Target Pair
Prostanoid EP1 Receptor


(Mus musculus (Mouse))
BDBM50424382
PNG
(CHEMBL2315057)
Show SMILES Cc1ccc(cc1)S(=O)(=O)NC(=O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1
Show InChI InChI=1S/C27H21Cl2FN2O4S/c1-17-5-10-23(11-6-17)37(34,35)32-27(33)25-4-2-3-22(31-25)14-19-13-20(28)9-12-26(19)36-16-18-7-8-21(29)15-24(18)30/h2-13,15H,14,16H2,1H3,(H,32,33)
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n/an/an/a 214n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Antagonist activity at mouse EP1 receptor expressed in CHOK1 cells assessed as inhibition of 17PTPGE2-induced calcium influx


Bioorg Med Chem Lett 23: 37-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.11.046
BindingDB Entry DOI: 10.7270/Q2WD41WD
More data for this
Ligand-Target Pair
Prostanoid EP1 Receptor


(Mus musculus (Mouse))
BDBM50424390
PNG
(CHEMBL2315049)
Show SMILES CC(C)CNC(=O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1
Show InChI InChI=1S/C24H23Cl2FN2O2/c1-15(2)13-28-24(30)22-5-3-4-20(29-22)11-17-10-18(25)8-9-23(17)31-14-16-6-7-19(26)12-21(16)27/h3-10,12,15H,11,13-14H2,1-2H3,(H,28,30)
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n/an/an/a 302n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Antagonist activity at mouse EP1 receptor expressed in CHOK1 cells assessed as inhibition of 17PTPGE2-induced calcium influx


Bioorg Med Chem Lett 23: 37-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.11.046
BindingDB Entry DOI: 10.7270/Q2WD41WD
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (EP1)


(Homo sapiens (Human))
BDBM85600
PNG
(CAS_146033-02-5 | CHEMBL155358 | NSC_132748 | SC-5...)
Show SMILES Clc1ccc2Oc3ccccc3CN(C(=O)NNC(=O)CCc3ccncc3)c2c1
Show InChI InChI=1S/C22H19ClN4O3/c23-17-6-7-20-18(13-17)27(14-16-3-1-2-4-19(16)30-20)22(29)26-25-21(28)8-5-15-9-11-24-12-10-15/h1-4,6-7,9-13H,5,8,14H2,(H,25,28)(H,26,29)
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n/an/an/a 316n/an/an/an/an/a



Searle

Curated by ChEMBL


Assay Description
PGE-2 (EP1 subtype) antagonistic activity as PGE2-stimulated guinea pig ileum muscle strip assay


J Med Chem 39: 609-13 (1996)


Article DOI: 10.1021/jm950454k
BindingDB Entry DOI: 10.7270/Q21R6RQ9
More data for this
Ligand-Target Pair
Prostanoid EP1 Receptor


(Mus musculus (Mouse))
BDBM50424387
PNG
(CHEMBL2315052)
Show SMILES CCN(CC)C(=O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1
Show InChI InChI=1S/C24H23Cl2FN2O2/c1-3-29(4-2)24(30)22-7-5-6-20(28-22)13-17-12-18(25)10-11-23(17)31-15-16-8-9-19(26)14-21(16)27/h5-12,14H,3-4,13,15H2,1-2H3
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n/an/an/a 447n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Antagonist activity at mouse EP1 receptor expressed in CHOK1 cells assessed as inhibition of 17PTPGE2-induced calcium influx


Bioorg Med Chem Lett 23: 37-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.11.046
BindingDB Entry DOI: 10.7270/Q2WD41WD
More data for this
Ligand-Target Pair
Prostanoid EP1 Receptor


(Mus musculus (Mouse))
BDBM50424393
PNG
(CHEMBL2315046)
Show SMILES Fc1cc(Cl)ccc1COc1ccc(Cl)cc1Cc1cccc(n1)C(=O)NCC1CC1
Show InChI InChI=1S/C24H21Cl2FN2O2/c25-18-8-9-23(31-14-16-6-7-19(26)12-21(16)27)17(10-18)11-20-2-1-3-22(29-20)24(30)28-13-15-4-5-15/h1-3,6-10,12,15H,4-5,11,13-14H2,(H,28,30)
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n/an/an/a 549n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Antagonist activity at mouse EP1 receptor expressed in CHOK1 cells assessed as inhibition of 17PTPGE2-induced calcium influx


Bioorg Med Chem Lett 23: 37-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.11.046
BindingDB Entry DOI: 10.7270/Q2WD41WD
More data for this
Ligand-Target Pair
Prostanoid EP1 Receptor


(Mus musculus (Mouse))
BDBM50424391
PNG
(CHEMBL2315048)
Show SMILES Fc1cc(Cl)ccc1COc1ccc(Cl)cc1Cc1cccc(n1)C(=O)NC1CCC1
Show InChI InChI=1S/C24H21Cl2FN2O2/c25-17-9-10-23(31-14-15-7-8-18(26)13-21(15)27)16(11-17)12-20-5-2-6-22(28-20)24(30)29-19-3-1-4-19/h2,5-11,13,19H,1,3-4,12,14H2,(H,29,30)
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n/an/an/a 912n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Antagonist activity at mouse EP1 receptor expressed in CHOK1 cells assessed as inhibition of 17PTPGE2-induced calcium influx


Bioorg Med Chem Lett 23: 37-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.11.046
BindingDB Entry DOI: 10.7270/Q2WD41WD
More data for this
Ligand-Target Pair
Prostanoid EP1 Receptor


(Mus musculus (Mouse))
BDBM50424389
PNG
(CHEMBL2315050)
Show SMILES CCC(C)NC(=O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1
Show InChI InChI=1S/C24H23Cl2FN2O2/c1-3-15(2)28-24(30)22-6-4-5-20(29-22)12-17-11-18(25)9-10-23(17)31-14-16-7-8-19(26)13-21(16)27/h4-11,13,15H,3,12,14H2,1-2H3,(H,28,30)
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n/an/an/a 1.38E+3n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Antagonist activity at mouse EP1 receptor expressed in CHOK1 cells assessed as inhibition of 17PTPGE2-induced calcium influx


Bioorg Med Chem Lett 23: 37-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.11.046
BindingDB Entry DOI: 10.7270/Q2WD41WD
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (EP1)


(Homo sapiens (Human))
BDBM50407972
PNG
(CHEMBL155667)
Show SMILES CCS(=O)(=O)CCC(=O)NNC(=O)N1Cc2ccccc2Oc2ccc(Cl)cc12
Show InChI InChI=1S/C19H20ClN3O5S/c1-2-29(26,27)10-9-18(24)21-22-19(25)23-12-13-5-3-4-6-16(13)28-17-8-7-14(20)11-15(17)23/h3-8,11H,2,9-10,12H2,1H3,(H,21,24)(H,22,25)
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n/an/an/a 1.58E+3n/an/an/an/an/a



Searle

Curated by ChEMBL


Assay Description
PGE-2 (EP1 subtype) antagonistic activity as PGE2-stimulated guinea pig ileum muscle strip assay


J Med Chem 39: 609-13 (1996)


Article DOI: 10.1021/jm950454k
BindingDB Entry DOI: 10.7270/Q21R6RQ9
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (EP1)


(Homo sapiens (Human))
BDBM50407969
PNG
(CHEMBL347397)
Show SMILES Clc1ccc2Oc3ccccc3CN(C(=O)CNC(=O)CCc3ccncc3)c2c1
Show InChI InChI=1S/C23H20ClN3O3/c24-18-6-7-21-19(13-18)27(15-17-3-1-2-4-20(17)30-21)23(29)14-26-22(28)8-5-16-9-11-25-12-10-16/h1-4,6-7,9-13H,5,8,14-15H2,(H,26,28)
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n/an/an/a 2.00E+3n/an/an/an/an/a



Searle

Curated by ChEMBL


Assay Description
PGE-2 (EP1 subtype) antagonistic activity as PGE2-stimulated guinea pig ileum muscle strip assay


J Med Chem 39: 609-13 (1996)


Article DOI: 10.1021/jm950454k
BindingDB Entry DOI: 10.7270/Q21R6RQ9
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (EP1)


(Homo sapiens (Human))
BDBM50407966
PNG
(CHEMBL348061)
Show SMILES CCS(=O)(=O)CCC(=O)NCC(=O)N1Cc2ccccc2Oc2ccc(Cl)cc12
Show InChI InChI=1S/C20H21ClN2O5S/c1-2-29(26,27)10-9-19(24)22-12-20(25)23-13-14-5-3-4-6-17(14)28-18-8-7-15(21)11-16(18)23/h3-8,11H,2,9-10,12-13H2,1H3,(H,22,24)
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n/an/an/a 2.00E+3n/an/an/an/an/a



Searle

Curated by ChEMBL


Assay Description
PGE-2 (EP1 subtype) antagonistic activity as PGE2-stimulated guinea pig ileum muscle strip assay


J Med Chem 39: 609-13 (1996)


Article DOI: 10.1021/jm950454k
BindingDB Entry DOI: 10.7270/Q21R6RQ9
More data for this
Ligand-Target Pair
Prostanoid EP1 Receptor


(Mus musculus (Mouse))
BDBM50424386
PNG
(CHEMBL2315053)
Show SMILES Fc1cc(Cl)ccc1COc1ccc(Cl)cc1Cc1cccc(n1)C(=O)NC1CC2CCC1C2
Show InChI InChI=1S/C27H25Cl2FN2O2/c28-20-8-9-26(34-15-18-6-7-21(29)14-23(18)30)19(12-20)13-22-2-1-3-24(31-22)27(33)32-25-11-16-4-5-17(25)10-16/h1-3,6-9,12,14,16-17,25H,4-5,10-11,13,15H2,(H,32,33)
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n/an/an/a 2.19E+3n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Antagonist activity at mouse EP1 receptor expressed in CHOK1 cells assessed as inhibition of 17PTPGE2-induced calcium influx


Bioorg Med Chem Lett 23: 37-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.11.046
BindingDB Entry DOI: 10.7270/Q2WD41WD
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (EP1)


(Homo sapiens (Human))
BDBM50407971
PNG
(CHEMBL346268)
Show SMILES CCS(=O)(=O)CCC(=O)CNC(=O)N1Cc2ccccc2Oc2ccc(Cl)cc12
Show InChI InChI=1S/C20H21ClN2O5S/c1-2-29(26,27)10-9-16(24)12-22-20(25)23-13-14-5-3-4-6-18(14)28-19-8-7-15(21)11-17(19)23/h3-8,11H,2,9-10,12-13H2,1H3,(H,22,25)
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n/an/an/a 2.51E+3n/an/an/an/an/a



Searle

Curated by ChEMBL


Assay Description
PGE-2 (EP1 subtype) antagonistic activity as PGE2-stimulated guinea pig ileum muscle strip assay


J Med Chem 39: 609-13 (1996)


Article DOI: 10.1021/jm950454k
BindingDB Entry DOI: 10.7270/Q21R6RQ9
More data for this
Ligand-Target Pair
Prostanoid EP1 Receptor


(Mus musculus (Mouse))
BDBM50424385
PNG
(CHEMBL2315054)
Show SMILES NC(=O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1
Show InChI InChI=1S/C20H15Cl2FN2O2/c21-14-6-7-19(27-11-12-4-5-15(22)10-17(12)23)13(8-14)9-16-2-1-3-18(25-16)20(24)26/h1-8,10H,9,11H2,(H2,24,26)
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n/an/an/a 2.63E+3n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Antagonist activity at mouse EP1 receptor expressed in CHOK1 cells assessed as inhibition of 17PTPGE2-induced calcium influx


Bioorg Med Chem Lett 23: 37-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.11.046
BindingDB Entry DOI: 10.7270/Q2WD41WD
More data for this
Ligand-Target Pair
Prostanoid EP1 Receptor


(Mus musculus (Mouse))
BDBM50424388
PNG
(CHEMBL2315051)
Show SMILES CC(C)(C)NC(=O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1
Show InChI InChI=1S/C24H23Cl2FN2O2/c1-24(2,3)29-23(30)21-6-4-5-19(28-21)12-16-11-17(25)9-10-22(16)31-14-15-7-8-18(26)13-20(15)27/h4-11,13H,12,14H2,1-3H3,(H,29,30)
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n/an/an/a 4.36E+3n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Antagonist activity at mouse EP1 receptor expressed in CHOK1 cells assessed as inhibition of 17PTPGE2-induced calcium influx


Bioorg Med Chem Lett 23: 37-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.11.046
BindingDB Entry DOI: 10.7270/Q2WD41WD
More data for this
Ligand-Target Pair
Prostanoid EP1 Receptor


(Mus musculus (Mouse))
BDBM50424392
PNG
(CHEMBL2315047)
Show SMILES Fc1cc(Cl)ccc1COc1ccc(Cl)cc1Cc1cccc(n1)C(=O)N1CCCC1
Show InChI InChI=1S/C24H21Cl2FN2O2/c25-18-8-9-23(31-15-16-6-7-19(26)14-21(16)27)17(12-18)13-20-4-3-5-22(28-20)24(30)29-10-1-2-11-29/h3-9,12,14H,1-2,10-11,13,15H2
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n/an/an/a 1.58E+4n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Antagonist activity at mouse EP1 receptor expressed in CHOK1 cells assessed as inhibition of 17PTPGE2-induced calcium influx


Bioorg Med Chem Lett 23: 37-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.11.046
BindingDB Entry DOI: 10.7270/Q2WD41WD
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (EP1)


(Homo sapiens (Human))
BDBM50160917
PNG
(3-(3-(2-(benzyloxy)-5-chlorophenyl)thiophen-2-yl)b...)
Show SMILES OC(=O)c1cccc(c1)-c1sccc1-c1cc(Cl)ccc1OCc1ccccc1
Show InChI InChI=1S/C24H17ClO3S/c25-19-9-10-22(28-15-16-5-2-1-3-6-16)21(14-19)20-11-12-29-23(20)17-7-4-8-18(13-17)24(26)27/h1-14H,15H2,(H,26,27)
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0.300n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against PGE2 activated EP1 receptor assessed as ability to inhibit intracellular calcium mobilisation by FLIPR


Bioorg Med Chem Lett 16: 2666-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.014
BindingDB Entry DOI: 10.7270/Q2J102RM
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (EP1)


(Homo sapiens (Human))
BDBM50419411
PNG
(CHEMBL1915012)
Show SMILES CC(C)c1cc2cc(Cl)cc(Cn3nc(cc3C)C(O)=O)c2o1
Show InChI InChI=1S/C17H17ClN2O3/c1-9(2)15-7-11-5-13(18)6-12(16(11)23-15)8-20-10(3)4-14(19-20)17(21)22/h4-7,9H,8H2,1-3H3,(H,21,22)
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0.398n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant EP1 receptor expressed in CHO-K1 cells assessed as inhibition of PGE2-mediated intracellular calcium mobiliz...


Bioorg Med Chem Lett 21: 4343-8 (2011)


Article DOI: 10.1016/j.bmcl.2011.05.047
BindingDB Entry DOI: 10.7270/Q2RN394N
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (EP1)


(Homo sapiens (Human))
BDBM50376788
PNG
(CHEMBL257997)
Show SMILES CC(C)Cc1cn(-c2nc(cs2)C([O-])=O)c2cc(Cl)ccc12
Show InChI InChI=1S/C16H15ClN2O2S/c1-9(2)5-10-7-19(14-6-11(17)3-4-12(10)14)16-18-13(8-22-16)15(20)21/h3-4,6-9H,5H2,1-2H3,(H,20,21)/p-1
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0.5n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against human EP1 receptor expressed in CHOK1 cells assessed as inhibition of PGE2-induced intracellular calcium mobilization by ...


Bioorg Med Chem Lett 18: 2684-90 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.018
BindingDB Entry DOI: 10.7270/Q2PC338K
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (EP1)


(Homo sapiens (Human))
BDBM85603
PNG
(CAS_5311503 | NSC_5311503 | ZK110841)
Show SMILES OC(C=CC1C(O)CC(Cl)C1CC=CCCCC(O)=O)C1CCCCC1
Show InChI InChI=1S/C21H33ClO4/c22-18-14-20(24)17(12-13-19(23)15-8-4-3-5-9-15)16(18)10-6-1-2-7-11-21(25)26/h1,6,12-13,15-20,23-24H,2-5,7-11,14H2,(H,25,26)
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1.80n/an/an/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by PDSP Ki Database




Biochim Biophys Acta 1483: 285-93 (2000)


BindingDB Entry DOI: 10.7270/Q2J964XQ
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (EP1)


(Homo sapiens (Human))
BDBM50259548
PNG
(6-(5'-chloro-2'-isobutoxy-biphenyl-2-yl)-pyridine-...)
Show SMILES CC(C)COc1ccc(Cl)cc1-c1ccccc1-c1cccc(n1)C([O-])=O
Show InChI InChI=1S/C22H20ClNO3/c1-14(2)13-27-21-11-10-15(23)12-18(21)16-6-3-4-7-17(16)19-8-5-9-20(24-19)22(25)26/h3-12,14H,13H2,1-2H3,(H,25,26)/p-1
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2.51n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from EP1 receptor


Bioorg Med Chem Lett 19: 497-501 (2008)


Article DOI: 10.1016/j.bmcl.2008.11.032
BindingDB Entry DOI: 10.7270/Q2N879N5
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (EP1)


(Homo sapiens (Human))
BDBM50160912
PNG
(1-{5-[3-(2-Benzyloxy-5-chloro-phenyl)-thiophen-2-y...)
Show SMILES OC(c1cncc(c1)-c1sccc1-c1cc(Cl)ccc1OCc1ccccc1)C(F)(F)F
Show InChI InChI=1S/C24H17ClF3NO2S/c25-18-6-7-21(31-14-15-4-2-1-3-5-15)20(11-18)19-8-9-32-22(19)16-10-17(13-29-12-16)23(30)24(26,27)28/h1-13,23,30H,14H2
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3n/an/an/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Binding affinity against Prostaglandin E receptor was determined in human


Bioorg Med Chem Lett 15: 1155-60 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.005
BindingDB Entry DOI: 10.7270/Q2SF2VNV
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (EP1)


(Homo sapiens (Human))
BDBM50160907
PNG
(5-[3-(2-Benzyloxy-5-chloro-phenyl)-thiophen-2-yl]-...)
Show SMILES OC(=O)c1cncc(c1)-c1sccc1-c1cc(Cl)ccc1OCc1ccccc1
Show InChI InChI=1S/C23H16ClNO3S/c24-18-6-7-21(28-14-15-4-2-1-3-5-15)20(11-18)19-8-9-29-22(19)16-10-17(23(26)27)13-25-12-16/h1-13H,14H2,(H,26,27)
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3n/an/an/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Binding affinity against Prostaglandin E receptor was determined in human


Bioorg Med Chem Lett 15: 1155-60 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.005
BindingDB Entry DOI: 10.7270/Q2SF2VNV
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (EP1)


(Homo sapiens (Human))
BDBM50160909
PNG
(1-{5-[3-(2-Benzyloxy-5-chloro-phenyl)-thiophen-2-y...)
Show SMILES OC(O)(c1cncc(c1)-c1sccc1-c1cc(Cl)ccc1OCc1ccccc1)C(F)(F)F
Show InChI InChI=1S/C24H17ClF3NO3S/c25-18-6-7-21(32-14-15-4-2-1-3-5-15)20(11-18)19-8-9-33-22(19)16-10-17(13-29-12-16)23(30,31)24(26,27)28/h1-13,30-31H,14H2
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4n/an/an/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Binding affinity against Prostaglandin E receptor was determined in human


Bioorg Med Chem Lett 15: 1155-60 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.005
BindingDB Entry DOI: 10.7270/Q2SF2VNV
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (EP1)


(Homo sapiens (Human))
BDBM50160917
PNG
(3-(3-(2-(benzyloxy)-5-chlorophenyl)thiophen-2-yl)b...)
Show SMILES OC(=O)c1cccc(c1)-c1sccc1-c1cc(Cl)ccc1OCc1ccccc1
Show InChI InChI=1S/C24H17ClO3S/c25-19-9-10-22(28-15-16-5-2-1-3-6-16)21(14-19)20-11-12-29-23(20)17-7-4-8-18(13-17)24(26)27/h1-14H,15H2,(H,26,27)
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4n/an/an/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Binding affinity against Prostaglandin E receptor was determined in human


Bioorg Med Chem Lett 15: 1155-60 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.005
BindingDB Entry DOI: 10.7270/Q2SF2VNV
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (EP1)


(Homo sapiens (Human))
BDBM50160915
PNG
(CHEMBL180046 | N-{3-[3-(2-Benzyloxy-5-chloro-pheny...)
Show SMILES Clc1ccc(OCc2ccccc2)c(c1)-c1ccsc1-c1cccc(NC(=O)Cc2ccccc2)c1
Show InChI InChI=1S/C31H24ClNO2S/c32-25-14-15-29(35-21-23-10-5-2-6-11-23)28(20-25)27-16-17-36-31(27)24-12-7-13-26(19-24)33-30(34)18-22-8-3-1-4-9-22/h1-17,19-20H,18,21H2,(H,33,34)
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4n/an/an/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Binding affinity against Prostaglandin E receptor was determined in human


Bioorg Med Chem Lett 15: 1155-60 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.005
BindingDB Entry DOI: 10.7270/Q2SF2VNV
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (EP1)


(Homo sapiens (Human))
BDBM50142480
PNG
((E)-7-[(1R,2S,3R)-3-Hydroxy-2-((E)-(S)-3-hydroxy-o...)
Show SMILES CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)N1C\C=C\CCCC(O)=O
Show InChI InChI=1S/C19H31NO5/c1-2-3-6-9-15(21)11-12-16-17(22)14-18(23)20(16)13-8-5-4-7-10-19(24)25/h5,8,11-12,15-17,21-22H,2-4,6-7,9-10,13-14H2,1H3,(H,24,25)/b8-5+,12-11+/t15-,16-,17+/m0/s1
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4.5n/an/an/an/an/an/an/an/a



Roche Palo Alto

Curated by ChEMBL


Assay Description
Binding affinity was determined against prostanoid EP1 receptor


Bioorg Med Chem Lett 14: 1655-9 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.063
BindingDB Entry DOI: 10.7270/Q2MK6CBC
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (EP1)


(Homo sapiens (Human))
BDBM50160915
PNG
(CHEMBL180046 | N-{3-[3-(2-Benzyloxy-5-chloro-pheny...)
Show SMILES Clc1ccc(OCc2ccccc2)c(c1)-c1ccsc1-c1cccc(NC(=O)Cc2ccccc2)c1
Show InChI InChI=1S/C31H24ClNO2S/c32-25-14-15-29(35-21-23-10-5-2-6-11-23)28(20-25)27-16-17-36-31(27)24-12-7-13-26(19-24)33-30(34)18-22-8-3-1-4-9-22/h1-17,19-20H,18,21H2,(H,33,34)
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5n/an/an/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Binding affinity against Prostaglandin E receptor in presence of 2% human serum albumin


Bioorg Med Chem Lett 15: 1155-60 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.005
BindingDB Entry DOI: 10.7270/Q2SF2VNV
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (EP1)


(Homo sapiens (Human))
BDBM50160909
PNG
(1-{5-[3-(2-Benzyloxy-5-chloro-phenyl)-thiophen-2-y...)
Show SMILES OC(O)(c1cncc(c1)-c1sccc1-c1cc(Cl)ccc1OCc1ccccc1)C(F)(F)F
Show InChI InChI=1S/C24H17ClF3NO3S/c25-18-6-7-21(32-14-15-4-2-1-3-5-15)20(11-18)19-8-9-33-22(19)16-10-17(13-29-12-16)23(30,31)24(26,27)28/h1-13,30-31H,14H2
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5n/an/an/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Binding affinity against Prostaglandin E receptor in presence of 2% human serum albumin


Bioorg Med Chem Lett 15: 1155-60 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.005
BindingDB Entry DOI: 10.7270/Q2SF2VNV
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (EP1)


(Homo sapiens (Human))
BDBM50160912
PNG
(1-{5-[3-(2-Benzyloxy-5-chloro-phenyl)-thiophen-2-y...)
Show SMILES OC(c1cncc(c1)-c1sccc1-c1cc(Cl)ccc1OCc1ccccc1)C(F)(F)F
Show InChI InChI=1S/C24H17ClF3NO2S/c25-18-6-7-21(31-14-15-4-2-1-3-5-15)20(11-18)19-8-9-32-22(19)16-10-17(13-29-12-16)23(30)24(26,27)28/h1-13,23,30H,14H2
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6n/an/an/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Binding affinity against Prostaglandin E receptor in presence of 2% human serum albumin


Bioorg Med Chem Lett 15: 1155-60 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.005
BindingDB Entry DOI: 10.7270/Q2SF2VNV
More data for this
Ligand-Target Pair
Prostanoid EP1 Receptor


(Mus musculus (Mouse))
BDBM50101853
PNG
((11alpha,13E,15S)-11,15-dihydroxy-9-oxoprost-13-en...)
Show SMILES CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(O)=O
Show InChI InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,19+/m0/s1
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6n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Affinity for mouse Prostanoid EP1 receptor expressed in CHO cells


Bioorg Med Chem Lett 11: 2033-5 (2001)


Article DOI: 10.1016/s0960-894x(01)00365-1
BindingDB Entry DOI: 10.7270/Q24B30K2
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (EP1)


(Homo sapiens (Human))
BDBM50160913
PNG
(6-[3-(2-Benzyloxy-5-chloro-phenyl)-thiophen-2-yl]-...)
Show SMILES OC(=O)c1cccc(n1)-c1sccc1-c1cc(Cl)ccc1OCc1ccccc1
Show InChI InChI=1S/C23H16ClNO3S/c24-16-9-10-21(28-14-15-5-2-1-3-6-15)18(13-16)17-11-12-29-22(17)19-7-4-8-20(25-19)23(26)27/h1-13H,14H2,(H,26,27)
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6n/an/an/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Binding affinity against Prostaglandin E receptor was determined in human


Bioorg Med Chem Lett 15: 1155-60 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.005
BindingDB Entry DOI: 10.7270/Q2SF2VNV
More data for this
Ligand-Target Pair
Prostanoid EP1 Receptor


(Mus musculus (Mouse))
BDBM35847
PNG
((15S)-prostaglandin E2 | (5Z,11alpha,13E,15S)-11,1...)
Show SMILES CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O
Show InChI InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1
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6n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGE2 from mouse EP1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting


Bioorg Med Chem Lett 22: 396-401 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.109
BindingDB Entry DOI: 10.7270/Q27P8ZT2
More data for this
Ligand-Target Pair
Prostanoid EP1 Receptor


(Mus musculus (Mouse))
BDBM35847
PNG
((15S)-prostaglandin E2 | (5Z,11alpha,13E,15S)-11,1...)
Show SMILES CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O
Show InChI InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1
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6n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGE2 from mouse EP1 receptor expressed in CHO cells after 60 mins by scintillation counting


Bioorg Med Chem 20: 2235-51 (2012)


Article DOI: 10.1016/j.bmc.2012.02.018
BindingDB Entry DOI: 10.7270/Q2542P2G
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (EP1)


(Homo sapiens (Human))
BDBM50259611
PNG
(CHEMBL467114 | sodium 6-(5-chloro-2-(4-chloro-2-fl...)
Show SMILES [O-]C(=O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1
Show InChI InChI=1S/C20H14Cl2FNO3/c21-14-6-7-19(27-11-12-4-5-15(22)10-17(12)23)13(8-14)9-16-2-1-3-18(24-16)20(25)26/h1-8,10H,9,11H2,(H,25,26)/p-1
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7.94n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant EP1 receptor expressed in CHO cells assessed as inhibition of PGE2-mediated intracellular calcium mobilizati...


Bioorg Med Chem Lett 19: 2599-603 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.112
BindingDB Entry DOI: 10.7270/Q2HT2P68
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (EP1)


(Homo sapiens (Human))
BDBM50410087
PNG
(CHEMBL2113029)
Show SMILES NS(=O)(=O)c1cccc(c1)-c1ccsc1-c1cc(Cl)ccc1OCc1ccccc1
Show InChI InChI=1S/C23H18ClNO3S2/c24-18-9-10-22(28-15-16-5-2-1-3-6-16)21(14-18)23-20(11-12-29-23)17-7-4-8-19(13-17)30(25,26)27/h1-14H,15H2,(H2,25,26,27)
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8n/an/an/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Binding affinity against Prostaglandin E receptor was determined in human


Bioorg Med Chem Lett 15: 1155-60 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.005
BindingDB Entry DOI: 10.7270/Q2SF2VNV
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (EP1)


(Homo sapiens (Human))
BDBM50160914
PNG
(3-[3-(2-Benzyloxy-5-chloro-phenyl)-thiophen-2-yl]-...)
Show SMILES CC(NC(=O)c1cccc(c1)-c1sccc1-c1cc(Cl)ccc1OCc1ccccc1)c1cccnc1
Show InChI InChI=1S/C31H25ClN2O2S/c1-21(25-11-6-15-33-19-25)34-31(35)24-10-5-9-23(17-24)30-27(14-16-37-30)28-18-26(32)12-13-29(28)36-20-22-7-3-2-4-8-22/h2-19,21H,20H2,1H3,(H,34,35)
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9n/an/an/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Binding affinity against Prostaglandin E receptor was determined in human


Bioorg Med Chem Lett 15: 1155-60 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.005
BindingDB Entry DOI: 10.7270/Q2SF2VNV
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (EP1)


(Homo sapiens (Human))
BDBM35847
PNG
((15S)-prostaglandin E2 | (5Z,11alpha,13E,15S)-11,1...)
Show SMILES CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O
Show InChI InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1
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9.10n/an/an/an/an/an/an/an/a



EMD-Serono Research Institute, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from human EP1 receptor


Bioorg Med Chem Lett 18: 821-4 (2008)


Article DOI: 10.1016/j.bmcl.2007.11.020
BindingDB Entry DOI: 10.7270/Q2W096SW
More data for this
Ligand-Target Pair
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