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Compile Data Set for Download or QSAR

Found 259 hits Enz. Inhib. hit(s) with Target = 'Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae (Baker's yeast))
BDBM50366477
PNG
(CHEMBL69330)
Show SMILES CC(C)=CCC\C(C)=C\CC\C(C)=C\CO[P@](O)(=O)OP(O)(O)=O
Show InChI InChI=1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/b14-9+,15-11+
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n/an/an/a 75n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of yeast Farnesyl transferase


Bioorg Med Chem Lett 7: 2125-2130 (1997)


Article DOI: 10.1016/S0960-894X(97)00373-9
BindingDB Entry DOI: 10.7270/Q2542P3X
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae (Baker's yeast))
BDBM50289981
PNG
(Prenyl pyrophosphate analogue | {[(2E,6E)-8-[(3-be...)
Show SMILES C\C(CC\C=C(/C)COC(=O)c1cccc(c1)C(=O)c1ccccc1)=C/COP([O-])(=O)OP([O-])([O-])=O
Show InChI InChI=1S/C24H28O10P2/c1-18(14-15-33-36(30,31)34-35(27,28)29)8-6-9-19(2)17-32-24(26)22-13-7-12-21(16-22)23(25)20-10-4-3-5-11-20/h3-5,7,9-14,16H,6,8,15,17H2,1-2H3,(H,30,31)(H2,27,28,29)/p-3/b18-14+,19-9+
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380n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of yeast Farnesyl transferase


Bioorg Med Chem Lett 7: 2125-2130 (1997)


Article DOI: 10.1016/S0960-894X(97)00373-9
BindingDB Entry DOI: 10.7270/Q2542P3X
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae (Baker's yeast))
BDBM50289982
PNG
(Prenyl pyrophosphate analogue)
Show SMILES C\C(CC\C=C(/C)CNC(=O)c1cccc(c1)C(=O)c1ccccc1)=C/COP([O-])(=O)OP([O-])([O-])=O
Show InChI InChI=1S/C24H29NO9P2/c1-18(14-15-33-36(31,32)34-35(28,29)30)8-6-9-19(2)17-25-24(27)22-13-7-12-21(16-22)23(26)20-10-4-3-5-11-20/h3-5,7,9-14,16H,6,8,15,17H2,1-2H3,(H,25,27)(H,31,32)(H2,28,29,30)/p-3/b18-14+,19-9+
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700n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of yeast Farnesyl transferase


Bioorg Med Chem Lett 7: 2125-2130 (1997)


Article DOI: 10.1016/S0960-894X(97)00373-9
BindingDB Entry DOI: 10.7270/Q2542P3X
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae (Baker's yeast))
BDBM50289979
PNG
(Prenyl pyrophosphate analogue | {[(2E)-4-[(3-benzo...)
Show SMILES C\C(COC(=O)c1cccc(c1)C(=O)c1ccccc1)=C/COP([O-])(=O)OP([O-])([O-])=O
Show InChI InChI=1S/C19H20O10P2/c1-14(10-11-28-31(25,26)29-30(22,23)24)13-27-19(21)17-9-5-8-16(12-17)18(20)15-6-3-2-4-7-15/h2-10,12H,11,13H2,1H3,(H,25,26)(H2,22,23,24)/p-3/b14-10+
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960n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of yeast Farnesyl transferase


Bioorg Med Chem Lett 7: 2125-2130 (1997)


Article DOI: 10.1016/S0960-894X(97)00373-9
BindingDB Entry DOI: 10.7270/Q2542P3X
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae (Baker's yeast))
BDBM50289978
PNG
(Prenyl pyrophosphate analogue | {[(2E)-4-[(3-benzo...)
Show SMILES C\C(CNC(=O)c1cccc(c1)C(=O)c1ccccc1)=C/COP([O-])(=O)OP([O-])([O-])=O
Show InChI InChI=1S/C19H21NO9P2/c1-14(10-11-28-31(26,27)29-30(23,24)25)13-20-19(22)17-9-5-8-16(12-17)18(21)15-6-3-2-4-7-15/h2-10,12H,11,13H2,1H3,(H,20,22)(H,26,27)(H2,23,24,25)/p-3/b14-10+
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6.00E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of yeast Farnesyl transferase


Bioorg Med Chem Lett 7: 2125-2130 (1997)


Article DOI: 10.1016/S0960-894X(97)00373-9
BindingDB Entry DOI: 10.7270/Q2542P3X
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae (Baker's yeast))
BDBM50144314
PNG
((2E,4E,6E,8E)-3,7,11-trimethyldodeca-2,4,6,8,10-pe...)
Show SMILES CC(C)=C\C=C\C(\C)=C\C=C\C(\C)=C\COP(O)(=O)OP(O)(O)=O
Show InChI InChI=1S/C15H24O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h5-11H,12H2,1-4H3,(H,19,20)(H2,16,17,18)/b8-5+,10-6+,14-9+,15-11+
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8.80E+3n/an/an/an/an/an/an/an/a



The University of Utah

Curated by ChEMBL


Assay Description
Dissociation constant against yeast farnesyltransferase


Bioorg Med Chem Lett 14: 2137-40 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.077
BindingDB Entry DOI: 10.7270/Q2S181Z3
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50067584
PNG
((S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-bip...)
Show SMILES CSCC[C@H](NC(=O)c1ccc(NC[C@@H](N)CS)cc1-c1ccccc1)C(O)=O
Show InChI InChI=1S/C21H27N3O3S2/c1-29-10-9-19(21(26)27)24-20(25)17-8-7-16(23-12-15(22)13-28)11-18(17)14-5-3-2-4-6-14/h2-8,11,15,19,23,28H,9-10,12-13,22H2,1H3,(H,24,25)(H,26,27)/t15-,19+/m1/s1
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n/an/a 1.00E+3n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
Inhibition of mammalian H-Ras processing in NIH 3T3 cells


Bioorg Med Chem Lett 11: 761-4 (2001)


Article DOI: 10.1016/s0960-894x(01)00055-5
BindingDB Entry DOI: 10.7270/Q26W99CH
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM16182
PNG
((2S)-2-[(4-{[(1H-imidazol-4-ylmethyl)amino]methyl}...)
Show SMILES CSCC[C@H](NC(=O)c1ccc(CNCc2cnc[nH]2)cc1-c1ccccc1C)C(O)=O
Show InChI InChI=1S/C24H28N4O3S/c1-16-5-3-4-6-19(16)21-11-17(12-25-13-18-14-26-15-27-18)7-8-20(21)23(29)28-22(24(30)31)9-10-32-2/h3-8,11,14-15,22,25H,9-10,12-13H2,1-2H3,(H,26,27)(H,28,29)(H,30,31)/t22-/m0/s1
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n/an/a 200n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
Inhibition of mammalian H-Ras processing in NIH 3T3 cells


Bioorg Med Chem Lett 11: 761-4 (2001)


Article DOI: 10.1016/s0960-894x(01)00055-5
BindingDB Entry DOI: 10.7270/Q26W99CH
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50097814
PNG
((S)-2-[(5-{[(1H-Imidazol-4-ylmethyl)-amino]-methyl...)
Show SMILES COC(=O)[C@H](CCSC)NC(=O)c1ccc(CNCc2cnc[nH]2)cc1-c1ccccc1C
Show InChI InChI=1S/C25H30N4O3S/c1-17-6-4-5-7-20(17)22-12-18(13-26-14-19-15-27-16-28-19)8-9-21(22)24(30)29-23(10-11-33-3)25(31)32-2/h4-9,12,15-16,23,26H,10-11,13-14H2,1-3H3,(H,27,28)(H,29,30)/t23-/m0/s1
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n/an/a 20n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
Inhibition of mammalian H-Ras processing in NIH 3T3 cells


Bioorg Med Chem Lett 11: 761-4 (2001)


Article DOI: 10.1016/s0960-894x(01)00055-5
BindingDB Entry DOI: 10.7270/Q26W99CH
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50097818
PNG
((S)-2-({5-[(1-Biphenyl-4-ylmethyl-1H-imidazol-4-yl...)
Show SMILES CSCC[C@H](NC(=O)c1ccc(NCc2cn(Cc3ccc(cc3)-c3ccccc3)cn2)cc1-c1ccccc1)C(O)=O
Show InChI InChI=1S/C35H34N4O3S/c1-43-19-18-33(35(41)42)38-34(40)31-17-16-29(20-32(31)28-10-6-3-7-11-28)36-21-30-23-39(24-37-30)22-25-12-14-27(15-13-25)26-8-4-2-5-9-26/h2-17,20,23-24,33,36H,18-19,21-22H2,1H3,(H,38,40)(H,41,42)/t33-/m0/s1
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Yale University

Curated by ChEMBL


Assay Description
Inhibition of mammalian H-Ras processing in NIH 3T3 cells


Bioorg Med Chem Lett 11: 761-4 (2001)


Article DOI: 10.1016/s0960-894x(01)00055-5
BindingDB Entry DOI: 10.7270/Q26W99CH
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50097809
PNG
((S)-2-[(5-{[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmet...)
Show SMILES CSCC[C@H](NC(=O)c1ccc(NCc2cncn2Cc2ccc(cc2)C#N)cc1-c1ccccc1)C(O)=O
Show InChI InChI=1S/C30H29N5O3S/c1-39-14-13-28(30(37)38)34-29(36)26-12-11-24(15-27(26)23-5-3-2-4-6-23)33-18-25-17-32-20-35(25)19-22-9-7-21(16-31)8-10-22/h2-12,15,17,20,28,33H,13-14,18-19H2,1H3,(H,34,36)(H,37,38)/t28-/m0/s1
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n/an/a 5.00E+3n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
Inhibition of mammalian H-Ras processing in NIH 3T3 cells


Bioorg Med Chem Lett 11: 761-4 (2001)


Article DOI: 10.1016/s0960-894x(01)00055-5
BindingDB Entry DOI: 10.7270/Q26W99CH
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50097813
PNG
(5-{[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-ami...)
Show SMILES O=C(NCCC#N)c1ccc(NCc2cncn2Cc2ccc(cc2)C#N)cc1-c1ccccc1
Show InChI InChI=1S/C28H24N6O/c29-13-4-14-32-28(35)26-12-11-24(15-27(26)23-5-2-1-3-6-23)33-18-25-17-31-20-34(25)19-22-9-7-21(16-30)8-10-22/h1-3,5-12,15,17,20,33H,4,14,18-19H2,(H,32,35)
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n/an/a 2.00E+4n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
Inhibition of mammalian H-Ras processing in NIH 3T3 cells


Bioorg Med Chem Lett 11: 761-4 (2001)


Article DOI: 10.1016/s0960-894x(01)00055-5
BindingDB Entry DOI: 10.7270/Q26W99CH
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50097816
PNG
(5-{[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-ami...)
Show SMILES O=C(NCC1CCCCC1)c1ccc(NCc2cncn2Cc2ccc(cc2)C#N)cc1-c1ccccc1
Show InChI InChI=1S/C32H33N5O/c33-18-24-11-13-26(14-12-24)22-37-23-34-20-29(37)21-35-28-15-16-30(31(17-28)27-9-5-2-6-10-27)32(38)36-19-25-7-3-1-4-8-25/h2,5-6,9-17,20,23,25,35H,1,3-4,7-8,19,21-22H2,(H,36,38)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
Inhibition of mammalian H-Ras processing in NIH 3T3 cells


Bioorg Med Chem Lett 11: 761-4 (2001)


Article DOI: 10.1016/s0960-894x(01)00055-5
BindingDB Entry DOI: 10.7270/Q26W99CH
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50097811
PNG
(5-{[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-ami...)
Show SMILES CC(C)NC(=O)c1ccc(NCc2cncn2Cc2ccc(cc2)C#N)cc1-c1ccccc1
Show InChI InChI=1S/C28H27N5O/c1-20(2)32-28(34)26-13-12-24(14-27(26)23-6-4-3-5-7-23)31-17-25-16-30-19-33(25)18-22-10-8-21(15-29)9-11-22/h3-14,16,19-20,31H,17-18H2,1-2H3,(H,32,34)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
Inhibition of mammalian H-Ras processing in NIH 3T3 cells


Bioorg Med Chem Lett 11: 761-4 (2001)


Article DOI: 10.1016/s0960-894x(01)00055-5
BindingDB Entry DOI: 10.7270/Q26W99CH
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50097808
PNG
((S)-4-Methylsulfanyl-2-({5-[(1-naphthalen-1-ylmeth...)
Show SMILES CSCC[C@H](NC(=O)c1ccc(NCc2cn(Cc3cccc4ccccc34)cn2)cc1-c1ccccc1)C(O)=O
Show InChI InChI=1S/C33H32N4O3S/c1-41-17-16-31(33(39)40)36-32(38)29-15-14-26(18-30(29)24-8-3-2-4-9-24)34-19-27-21-37(22-35-27)20-25-12-7-11-23-10-5-6-13-28(23)25/h2-15,18,21-22,31,34H,16-17,19-20H2,1H3,(H,36,38)(H,39,40)/t31-/m0/s1
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Yale University

Curated by ChEMBL


Assay Description
Inhibition of mammalian H-Ras processing in NIH 3T3 cells


Bioorg Med Chem Lett 11: 761-4 (2001)


Article DOI: 10.1016/s0960-894x(01)00055-5
BindingDB Entry DOI: 10.7270/Q26W99CH
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50097810
PNG
((S)-2-({5-[(3-Biphenyl-4-ylmethyl-3H-imidazol-4-yl...)
Show SMILES CSCC[C@H](NC(=O)c1ccc(NCc2cncn2Cc2ccc(cc2)-c2ccccc2)cc1-c1ccccc1)C(O)=O
Show InChI InChI=1S/C35H34N4O3S/c1-43-19-18-33(35(41)42)38-34(40)31-17-16-29(20-32(31)28-10-6-3-7-11-28)37-22-30-21-36-24-39(30)23-25-12-14-27(15-13-25)26-8-4-2-5-9-26/h2-17,20-21,24,33,37H,18-19,22-23H2,1H3,(H,38,40)(H,41,42)/t33-/m0/s1
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Yale University

Curated by ChEMBL


Assay Description
Inhibition of mammalian H-Ras processing in NIH 3T3 cells


Bioorg Med Chem Lett 11: 761-4 (2001)


Article DOI: 10.1016/s0960-894x(01)00055-5
BindingDB Entry DOI: 10.7270/Q26W99CH
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae (Baker's yeast))
BDBM238367
PNG
(3-(4-Tolyl)-4-cyano-5-(isopropylthio)thiophene-2-c...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccc(C)cc1
Show InChI InChI=1S/C16H15NO2S2/c1-9(2)20-16-12(8-17)13(14(21-16)15(18)19)11-6-4-10(3)5-7-11/h4-7,9H,1-3H3,(H,18,19)
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n/an/a 190n/an/an/an/an/an/a



Centre de Recherche de Gif



Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae (Baker's yeast))
BDBM238368
PNG
(3-(3-Tolyl)-4-cyano-5-(isopropylthio)thiophene-2-c...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1cccc(C)c1
Show InChI InChI=1S/C16H15NO2S2/c1-9(2)20-16-12(8-17)13(14(21-16)15(18)19)11-6-4-5-10(3)7-11/h4-7,9H,1-3H3,(H,18,19)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Centre de Recherche de Gif



Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae (Baker's yeast))
BDBM238369
PNG
(3-(2-Tolyl)-4-cyano-5-(isopropylthio)thiophene-2-c...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccccc1C
Show InChI InChI=1S/C16H15NO2S2/c1-9(2)20-16-12(8-17)13(14(21-16)15(18)19)11-7-5-4-6-10(11)3/h4-7,9H,1-3H3,(H,18,19)
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Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae (Baker's yeast))
BDBM238370
PNG
(3-(1-Naphthyl)-4-cyano-5-(isopropylthio)thiophene-...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1cccc2ccccc12
Show InChI InChI=1S/C19H15NO2S2/c1-11(2)23-19-15(10-20)16(17(24-19)18(21)22)14-9-5-7-12-6-3-4-8-13(12)14/h3-9,11H,1-2H3,(H,21,22)
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Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae (Baker's yeast))
BDBM238371
PNG
(3-(2-Naphthyl)-4-cyano-5-(isopropylthio)thiophene-...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccc2ccccc2c1
Show InChI InChI=1S/C19H15NO2S2/c1-11(2)23-19-15(10-20)16(17(24-19)18(21)22)14-8-7-12-5-3-4-6-13(12)9-14/h3-9,11H,1-2H3,(H,21,22)
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Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae (Baker's yeast))
BDBM238372
PNG
(3-(4-Biphenyl)-4-cyano-5-(isopropylthio)thiophene-...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C21H17NO2S2/c1-13(2)25-21-17(12-22)18(19(26-21)20(23)24)16-10-8-15(9-11-16)14-6-4-3-5-7-14/h3-11,13H,1-2H3,(H,23,24)
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Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae (Baker's yeast))
BDBM238373
PNG
(3-(3-Biphenyl)-4-cyano-5-(isopropylthio)thiophene-...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C21H17NO2S2/c1-13(2)25-21-17(12-22)18(19(26-21)20(23)24)16-10-6-9-15(11-16)14-7-4-3-5-8-14/h3-11,13H,1-2H3,(H,23,24)
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Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae (Baker's yeast))
BDBM238374
PNG
(3-(3-Thienyl)-4-cyano-5-(isopropylthio)thiophene-2...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(Sc2ccsc2)c1C#N
Show InChI InChI=1S/C13H11NO2S4/c1-7(2)18-13-9(5-14)10(11(20-13)12(15)16)19-8-3-4-17-6-8/h3-4,6-7H,1-2H3,(H,15,16)
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Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae (Baker's yeast))
BDBM238375
PNG
(3-(1-Dibenzofuranyl)-4-cyano-5-(isopropylthio)thio...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1cccc2oc3ccccc3c12
Show InChI InChI=1S/C21H15NO3S2/c1-11(2)26-21-14(10-22)18(19(27-21)20(23)24)13-7-5-9-16-17(13)12-6-3-4-8-15(12)25-16/h3-9,11H,1-2H3,(H,23,24)
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Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae (Baker's yeast))
BDBM50067584
PNG
((S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-bip...)
Show SMILES CSCC[C@H](NC(=O)c1ccc(NC[C@@H](N)CS)cc1-c1ccccc1)C(O)=O
Show InChI InChI=1S/C21H27N3O3S2/c1-29-10-9-19(21(26)27)24-20(25)17-8-7-16(23-12-15(22)13-28)11-18(17)14-5-3-2-4-6-14/h2-8,11,15,19,23,28H,9-10,12-13,22H2,1H3,(H,24,25)(H,26,27)/t15-,19+/m1/s1
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Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae (Baker's yeast))
BDBM238353
PNG
(3-(4-Chlorophenyl)-4-cyano-5-(isopropylthio)thioph...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccc(Cl)cc1
Show InChI InChI=1S/C15H12ClNO2S2/c1-8(2)20-15-11(7-17)12(13(21-15)14(18)19)9-3-5-10(16)6-4-9/h3-6,8H,1-2H3,(H,18,19)
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Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae (Baker's yeast))
BDBM238354
PNG
(3-(3-Chlorophenyl)-4-cyano-5-(isopropylthio)thioph...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1cccc(Cl)c1
Show InChI InChI=1S/C15H12ClNO2S2/c1-8(2)20-15-11(7-17)12(13(21-15)14(18)19)9-4-3-5-10(16)6-9/h3-6,8H,1-2H3,(H,18,19)
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Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae (Baker's yeast))
BDBM238355
PNG
(3-(2-Chlorophenyl)-4-cyano-5-(isopropylthio)thioph...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccccc1Cl
Show InChI InChI=1S/C15H12ClNO2S2/c1-8(2)20-15-10(7-17)12(13(21-15)14(18)19)9-5-3-4-6-11(9)16/h3-6,8H,1-2H3,(H,18,19)
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Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae (Baker's yeast))
BDBM238356
PNG
(3-(4-Fluorophenyl)-4-cyano-5-(isopropylthio)thioph...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccc(F)cc1
Show InChI InChI=1S/C15H12FNO2S2/c1-8(2)20-15-11(7-17)12(13(21-15)14(18)19)9-3-5-10(16)6-4-9/h3-6,8H,1-2H3,(H,18,19)
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Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae (Baker's yeast))
BDBM238357
PNG
(3-(3-Fluorophenyl)-4-cyano-5-(isopropylthio)thioph...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1cccc(F)c1
Show InChI InChI=1S/C15H12FNO2S2/c1-8(2)20-15-11(7-17)12(13(21-15)14(18)19)9-4-3-5-10(16)6-9/h3-6,8H,1-2H3,(H,18,19)
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Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae (Baker's yeast))
BDBM238358
PNG
(3-(2-Fluorophenyl)-4-cyano-5-(isopropylthio)thioph...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccccc1F
Show InChI InChI=1S/C15H12FNO2S2/c1-8(2)20-15-10(7-17)12(13(21-15)14(18)19)9-5-3-4-6-11(9)16/h3-6,8H,1-2H3,(H,18,19)
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Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae (Baker's yeast))
BDBM238359
PNG
(3-(4-(Trifluoromethyl)phenyl)-4-cyano-5-(isopropyl...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C16H12F3NO2S2/c1-8(2)23-15-11(7-20)12(13(24-15)14(21)22)9-3-5-10(6-4-9)16(17,18)19/h3-6,8H,1-2H3,(H,21,22)
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Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae (Baker's yeast))
BDBM238360
PNG
(3-(3-(Trifluoromethyl)phenyl)-4-cyano-5-(isopropyl...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C16H12F3NO2S2/c1-8(2)23-15-11(7-20)12(13(24-15)14(21)22)9-4-3-5-10(6-9)16(17,18)19/h3-6,8H,1-2H3,(H,21,22)
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Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae (Baker's yeast))
BDBM238361
PNG
(3-(4-Methoxyphenyl)-4-cyano-5-(isopropylthio)thiop...)
Show SMILES COc1ccc(cc1)-c1c(sc(SC(C)C)c1C#N)C(O)=O
Show InChI InChI=1S/C16H15NO3S2/c1-9(2)21-16-12(8-17)13(14(22-16)15(18)19)10-4-6-11(20-3)7-5-10/h4-7,9H,1-3H3,(H,18,19)
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Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae (Baker's yeast))
BDBM238362
PNG
(3-(3-Methoxyphenyl)-4-cyano-5-(isopropylthio)thiop...)
Show SMILES COc1cccc(c1)-c1c(sc(SC(C)C)c1C#N)C(O)=O
Show InChI InChI=1S/C16H15NO3S2/c1-9(2)21-16-12(8-17)13(14(22-16)15(18)19)10-5-4-6-11(7-10)20-3/h4-7,9H,1-3H3,(H,18,19)
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Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae (Baker's yeast))
BDBM238363
PNG
(3-(2-Methoxyphenyl)-4-cyano-5-(isopropylthio)thiop...)
Show SMILES COc1ccccc1-c1c(sc(SC(C)C)c1C#N)C(O)=O
Show InChI InChI=1S/C16H15NO3S2/c1-9(2)21-16-11(8-17)13(14(22-16)15(18)19)10-6-4-5-7-12(10)20-3/h4-7,9H,1-3H3,(H,18,19)
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Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae (Baker's yeast))
BDBM238364
PNG
(3-(4-(Methoxycarbonyl)phenyl)-4-cyano-5-(isopropyl...)
Show SMILES COC(=O)c1ccc(cc1)-c1c(sc(SC(C)C)c1C#N)C(O)=O
Show InChI InChI=1S/C17H15NO4S2/c1-9(2)23-17-12(8-18)13(14(24-17)15(19)20)10-4-6-11(7-5-10)16(21)22-3/h4-7,9H,1-3H3,(H,19,20)
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Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae (Baker's yeast))
BDBM238365
PNG
(3-(3-(Methoxycarbonyl)phenyl)-4-cyano-5-(isopropyl...)
Show SMILES COC(=O)c1cccc(c1)-c1c(sc(SC(C)C)c1C#N)C(O)=O
Show InChI InChI=1S/C17H15NO4S2/c1-9(2)23-17-12(8-18)13(14(24-17)15(19)20)10-5-4-6-11(7-10)16(21)22-3/h4-7,9H,1-3H3,(H,19,20)
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n/an/a 620n/an/an/an/an/an/a



Centre de Recherche de Gif



Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae (Baker's yeast))
BDBM238366
PNG
(3-Phenyl-4-cyano-5-(isopropylthio)thiophene-2-carb...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccccc1
Show InChI InChI=1S/C15H13NO2S2/c1-9(2)19-15-11(8-16)12(13(20-15)14(17)18)10-6-4-3-5-7-10/h3-7,9H,1-2H3,(H,17,18)
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n/an/a 610n/an/an/an/an/an/a



Centre de Recherche de Gif



Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50076127
PNG
((S)-2-{[5-(2-Imidazol-1-yl-ethoxy)-biphenyl-2-carb...)
Show SMILES CC(C)C[C@H](NC(=O)c1ccc(OCCn2ccnc2)cc1-c1ccccc1)C(O)=O
Show InChI InChI=1S/C24H27N3O4/c1-17(2)14-22(24(29)30)26-23(28)20-9-8-19(31-13-12-27-11-10-25-16-27)15-21(20)18-6-4-3-5-7-18/h3-11,15-17,22H,12-14H2,1-2H3,(H,26,28)(H,29,30)/t22-/m0/s1
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PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
In vivo for inhibition of farnesylation based on the inhibition of H-Ras processing.


J Med Chem 42: 1333-40 (1999)


Article DOI: 10.1021/jm9900873
BindingDB Entry DOI: 10.7270/Q28G8JW7
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50076145
PNG
((S)-4-Methyl-2-{2-naphthalen-1-yl-4-[(pyridin-4-yl...)
Show SMILES CC(C)C[C@H](NC(=O)c1ccc(NCc2ccncc2)cc1-c1cccc2ccccc12)C(O)=O
Show InChI InChI=1S/C29H29N3O3/c1-19(2)16-27(29(34)35)32-28(33)25-11-10-22(31-18-20-12-14-30-15-13-20)17-26(25)24-9-5-7-21-6-3-4-8-23(21)24/h3-15,17,19,27,31H,16,18H2,1-2H3,(H,32,33)(H,34,35)/t27-/m0/s1
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n/an/a>3.00E+4n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
In vivo for inhibition of farnesylation based on the inhibition of H-Ras processing.


J Med Chem 42: 1333-40 (1999)


Article DOI: 10.1021/jm9900873
BindingDB Entry DOI: 10.7270/Q28G8JW7
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50076137
PNG
((S)-2-({3-[(1H-Imidazol-4-ylmethyl)-amino]-bipheny...)
Show SMILES CC(C)C[C@H](NC(=O)c1c(NCc2cnc[nH]2)cccc1-c1ccccc1)C(O)=O
Show InChI InChI=1S/C23H26N4O3/c1-15(2)11-20(23(29)30)27-22(28)21-18(16-7-4-3-5-8-16)9-6-10-19(21)25-13-17-12-24-14-26-17/h3-10,12,14-15,20,25H,11,13H2,1-2H3,(H,24,26)(H,27,28)(H,29,30)/t20-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
In vivo for inhibition of farnesylation based on the inhibition of H-Ras processing.


J Med Chem 42: 1333-40 (1999)


Article DOI: 10.1021/jm9900873
BindingDB Entry DOI: 10.7270/Q28G8JW7
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50076141
PNG
((S)-2-[4-((R)-2-Amino-3-mercapto-propylamino)-2-na...)
Show SMILES CC(C)C[C@H](NC(=O)c1ccc(NC[C@@H](N)CS)cc1-c1cccc2ccccc12)C(O)=O
Show InChI InChI=1S/C26H31N3O3S/c1-16(2)12-24(26(31)32)29-25(30)22-11-10-19(28-14-18(27)15-33)13-23(22)21-9-5-7-17-6-3-4-8-20(17)21/h3-11,13,16,18,24,28,33H,12,14-15,27H2,1-2H3,(H,29,30)(H,31,32)/t18-,24+/m1/s1
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n/an/a>3.00E+4n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
In vivo for inhibition of farnesylation based on the inhibition of H-Ras processing.


J Med Chem 42: 1333-40 (1999)


Article DOI: 10.1021/jm9900873
BindingDB Entry DOI: 10.7270/Q28G8JW7
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50076126
PNG
((S)-2-({5-[(1H-Imidazol-4-ylmethyl)-amino]-bipheny...)
Show SMILES CC(C)C[C@H](NC(=O)c1ccc(NCc2cnc[nH]2)cc1-c1ccccc1)C(O)=O
Show InChI InChI=1S/C23H26N4O3/c1-15(2)10-21(23(29)30)27-22(28)19-9-8-17(25-13-18-12-24-14-26-18)11-20(19)16-6-4-3-5-7-16/h3-9,11-12,14-15,21,25H,10,13H2,1-2H3,(H,24,26)(H,27,28)(H,29,30)/t21-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
In vivo for inhibition of farnesylation based on the inhibition of H-Ras processing.


J Med Chem 42: 1333-40 (1999)


Article DOI: 10.1021/jm9900873
BindingDB Entry DOI: 10.7270/Q28G8JW7
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50076131
PNG
((S)-2-{4-[(1H-Imidazol-2-ylmethyl)-amino]-2-naphth...)
Show SMILES CC(C)C[C@H](NC(=O)c1ccc(NCc2ncc[nH]2)cc1-c1cccc2ccccc12)C(O)=O
Show InChI InChI=1S/C27H28N4O3/c1-17(2)14-24(27(33)34)31-26(32)22-11-10-19(30-16-25-28-12-13-29-25)15-23(22)21-9-5-7-18-6-3-4-8-20(18)21/h3-13,15,17,24,30H,14,16H2,1-2H3,(H,28,29)(H,31,32)(H,33,34)/t24-/m0/s1
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n/an/a>3.00E+4n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
In vivo for inhibition of farnesylation based on the inhibition of H-Ras processing.


J Med Chem 42: 1333-40 (1999)


Article DOI: 10.1021/jm9900873
BindingDB Entry DOI: 10.7270/Q28G8JW7
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50076130
PNG
((S)-2-(4-{[(1H-Imidazol-4-ylmethyl)-amino]-methyl}...)
Show SMILES CC(C)C[C@H](NC(=O)c1ccc(CNCc2cnc[nH]2)cc1-c1cccc2ccccc12)C(O)=O
Show InChI InChI=1S/C28H30N4O3/c1-18(2)12-26(28(34)35)32-27(33)24-11-10-19(14-29-15-21-16-30-17-31-21)13-25(24)23-9-5-7-20-6-3-4-8-22(20)23/h3-11,13,16-18,26,29H,12,14-15H2,1-2H3,(H,30,31)(H,32,33)(H,34,35)/t26-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
In vivo for inhibition of farnesylation based on the inhibition of H-Ras processing.


J Med Chem 42: 1333-40 (1999)


Article DOI: 10.1021/jm9900873
BindingDB Entry DOI: 10.7270/Q28G8JW7
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50076128
PNG
((S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-bip...)
Show SMILES CC(C)C[C@H](NC(=O)c1ccc(NC[C@@H](N)CS)cc1-c1ccccc1)C(O)=O
Show InChI InChI=1S/C22H29N3O3S/c1-14(2)10-20(22(27)28)25-21(26)18-9-8-17(24-12-16(23)13-29)11-19(18)15-6-4-3-5-7-15/h3-9,11,14,16,20,24,29H,10,12-13,23H2,1-2H3,(H,25,26)(H,27,28)/t16-,20+/m1/s1
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n/an/a>3.00E+4n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
In vivo for inhibition of farnesylation based on the inhibition of H-Ras processing.


J Med Chem 42: 1333-40 (1999)


Article DOI: 10.1021/jm9900873
BindingDB Entry DOI: 10.7270/Q28G8JW7
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50076134
PNG
((S)-2-({5-[(1H-Imidazol-4-ylmethyl)-amino]-bipheny...)
Show SMILES COC(=O)[C@H](CC(C)C)NC(=O)c1ccc(NCc2cnc[nH]2)cc1-c1ccccc1
Show InChI InChI=1S/C24H28N4O3/c1-16(2)11-22(24(30)31-3)28-23(29)20-10-9-18(26-14-19-13-25-15-27-19)12-21(20)17-7-5-4-6-8-17/h4-10,12-13,15-16,22,26H,11,14H2,1-3H3,(H,25,27)(H,28,29)/t22-/m0/s1
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n/an/a>3.00E+4n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
In vivo for inhibition of farnesylation based on the inhibition of H-Ras processing.


J Med Chem 42: 1333-40 (1999)


Article DOI: 10.1021/jm9900873
BindingDB Entry DOI: 10.7270/Q28G8JW7
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50076135
PNG
((2S)-2-(4-((1H-imidazol-4-yl)methylamino)-2-(napht...)
Show SMILES CC(C)C[C@H](NC(=O)c1ccc(NCc2cnc[nH]2)cc1-c1cccc2ccccc12)C(O)=O
Show InChI InChI=1S/C27H28N4O3/c1-17(2)12-25(27(33)34)31-26(32)23-11-10-19(29-15-20-14-28-16-30-20)13-24(23)22-9-5-7-18-6-3-4-8-21(18)22/h3-11,13-14,16-17,25,29H,12,15H2,1-2H3,(H,28,30)(H,31,32)(H,33,34)/t25-/m0/s1
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n/an/a>3.00E+4n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
In vivo for inhibition of farnesylation based on the inhibition of H-Ras processing.


J Med Chem 42: 1333-40 (1999)


Article DOI: 10.1021/jm9900873
BindingDB Entry DOI: 10.7270/Q28G8JW7
More data for this
Ligand-Target Pair
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