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Found 829 Enz. Inhib. hit(s) with Target = 'Purine nucleoside phosphorylase'
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Albert Einstein College Of Medicine

Curated by ChEMBL
LigandPNGBDBM22109(7-{[(3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidin-...)
Affinity DataKd:  0.00850nMAssay Description:Binding affinity to human PNPMore data for this Ligand-Target Pair
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Albert Einstein College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50293091(7-({[(1R,2S)-2,3-DIHYDROXY-1-(HYDROXYMETHYL)PROPYL...)
Affinity DataKd:  0.00860nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
TargetPurine nucleoside phosphorylase(Bos taurus (bovine))
University Of Warsaw

Curated by ChEMBL
LigandPNGBDBM50195587(1,4-DIDEOXY-4-AZA-1-(S)-(9-DEAZAHYPOXANTHIN-9-YL)-...)
Affinity DataKd:  0.0230nMAssay Description:Binding affinity to calf recombinant PNP expressed in Escherichia coli BL21 (DE3) by isothermal titration calorimetryMore data for this Ligand-Target Pair
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Albert Einstein College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50195587(1,4-DIDEOXY-4-AZA-1-(S)-(9-DEAZAHYPOXANTHIN-9-YL)-...)
Affinity DataKd:  0.0560nMAssay Description:Inhibition of human PNPMore data for this Ligand-Target Pair
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Albert Einstein College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50195587(1,4-DIDEOXY-4-AZA-1-(S)-(9-DEAZAHYPOXANTHIN-9-YL)-...)
Affinity DataKd:  0.0580nMAssay Description:Binding affinity to human PNPMore data for this Ligand-Target Pair
TargetPurine nucleoside phosphorylase(Bos taurus (bovine))
University Of Warsaw

Curated by ChEMBL
LigandPNGBDBM50214707(9-(5',5'-Difluoro-5'-phosphonopentyl)-9-deazaguani...)
Affinity DataKd:  0.100nMAssay Description:Binding affinity to calf recombinant PNP expressed in Escherichia coli BL21 (DE3) by isothermal titration calorimetry/ fluorimetric titration analysi...More data for this Ligand-Target Pair
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Albert Einstein College Of Medicine

Curated by ChEMBL
LigandPNGBDBM92929(Immucillins, 13)
Affinity DataKd:  0.156nMAssay Description:Inhibition assay using human PNP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Albert Einstein College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50293060(7-{(1S)-1-[(1,3-Dihydroxypropan-2-yl)amino]-2-hydr...)
Affinity DataKd:  0.210nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Albert Einstein College Of Medicine

Curated by ChEMBL
LigandPNGBDBM92927(Immucillins, 11)
Affinity DataKd:  0.383nMAssay Description:Inhibition assay using human PNP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Bos taurus (bovine))
University Of Warsaw

Curated by ChEMBL
LigandPNGBDBM50214705(5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-1,1-di...)
Affinity DataKd:  0.460nMAssay Description:Binding affinity to calf recombinant PNP expressed in Escherichia coli BL21 (DE3) by isothermal titration calorimetry/ fluorimetric titration analysi...More data for this Ligand-Target Pair
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Albert Einstein College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50293063(7-{[(1,3-Dihydroxypropan-2-yl)(2-hydroxyethyl)amin...)
Affinity DataKd:  0.469nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Albert Einstein College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50293064(7-({[1,3-Dihydroxy-2-(hydroxymethyl)propan-2-yl]am...)
Affinity DataKd:  0.620nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Albert Einstein College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50293085(7-({[(2R/S,3S/R)-3,4-Dihydroxy-2-(hydroxymethyl)bu...)
Affinity DataKd:  0.780nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Albert Einstein College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50293067(7-({[(2S,3R)-1,3,4-Trihydroxybutan-2-yl]amino}meth...)
Affinity DataKd:  1nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Albert Einstein College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50293068(7-{[(2-Hydroxyethyl)amino]methyl}-3,5-dihydro-4H-p...)
Affinity DataKd:  1.10nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Albert Einstein College Of Medicine

Curated by ChEMBL
LigandPNGBDBM136302(US8853224, 12 | US9290501, MT-TrisMe-ImmH)
Affinity DataKd:  3nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPurine nucleoside phosphorylase(Bos taurus (bovine))
University Of Warsaw

Curated by ChEMBL
LigandPNGBDBM50394444(CHEMBL2159649)
Affinity DataKd:  3.60nMAssay Description:Binding affinity to calf recombinant PNP expressed in Escherichia coli BL21 (DE3) by isothermal titration calorimetry/ fluorimetric titration analysi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Albert Einstein College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50293070(7-({[3-Hydroxy-2-(hydroxymethyl)propyl](methyl)ami...)
Affinity DataKd:  3.70nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Albert Einstein College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50293071(7-({[(2S)-2,3-Dihydroxypropyl]amino}methyl)-3,5-di...)
Affinity DataKd:  4.20nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Albert Einstein College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50293072(7-({[(2R,3R)-1,3,4-Trihydroxybutan-2-yl]amino}meth...)
Affinity DataKd:  4.30nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Albert Einstein College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50293073(7-({[(2S,3S)-1,3,4-Trihydroxybutan-2-yl]amino}meth...)
Affinity DataKd:  5.20nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Albert Einstein College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50330392(7-(pyrrolidin-1-ylmethyl)-3H-pyrrolo[3,2-d]pyrimid...)
Affinity DataKd:  5.5nMAssay Description:Inhibition of human PNPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Albert Einstein College Of Medicine

Curated by ChEMBL
LigandPNGBDBM136310(US8853224, 28)
Affinity DataKd:  5.60nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Albert Einstein College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50293075(7-({[3-Hydroxy-2-(hydroxymethyl)propyl]amino}methy...)
Affinity DataKd:  14.1nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Albert Einstein College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50293076(7-({[(2R)-2,3-Dihydroxypropyl]amino}methyl)-3,5-di...)
Affinity DataKd:  14.9nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Albert Einstein College Of Medicine

Curated by ChEMBL
LigandPNGBDBM136306(US8853224, 24)
Affinity DataKd:  15nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPurine nucleoside phosphorylase(Plasmodium falciparum)
Industrial Research

US Patent
LigandPNGBDBM136306(US8853224, 24)
Affinity DataKd:  19nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Albert Einstein College Of Medicine

Curated by ChEMBL
LigandPNGBDBM136312(US8853224, 29)
Affinity DataKd:  22nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Albert Einstein College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50293077(7-{[(4-Hydroxybutyl)amino]methyl}-3,5-dihydro-4H-p...)
Affinity DataKd:  25nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Albert Einstein College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50293078(7-({[(2S,3R)-2,3,4-Trihydroxybutyl]amino}methyl)-3...)
Affinity DataKd:  31nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Albert Einstein College Of Medicine

Curated by ChEMBL
LigandPNGBDBM136313(US8853224, 19)
Affinity DataKd:  51nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Albert Einstein College Of Medicine

Curated by ChEMBL
LigandPNGBDBM92930(Immucillins, 14)
Affinity DataKd:  53nMAssay Description:Inhibition assay using human PNP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Plasmodium falciparum)
Industrial Research

US Patent
LigandPNGBDBM50293091(7-({[(1R,2S)-2,3-DIHYDROXY-1-(HYDROXYMETHYL)PROPYL...)
Affinity DataKd:  55nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPurine nucleoside phosphorylase(Plasmodium falciparum)
Industrial Research

US Patent
LigandPNGBDBM50293091(7-({[(1R,2S)-2,3-DIHYDROXY-1-(HYDROXYMETHYL)PROPYL...)
Affinity DataKd:  55nMAssay Description:Binding affinity to Plasmodium falciparum His6-tagged PNP assessed as reduction in uric acid formation using inosine as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Albert Einstein College Of Medicine

Curated by ChEMBL
LigandPNGBDBM136308(US8853224, 26)
Affinity DataKd:  71nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Albert Einstein College Of Medicine

Curated by ChEMBL
LigandPNGBDBM136307(US8853224, 25)
Affinity DataKd:  74nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Albert Einstein College Of Medicine

Curated by ChEMBL
LigandPNGBDBM136304(US8853224, 20.5)
Affinity DataKd:  84nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Albert Einstein College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50293081(7-({[(2R)-2,3-Dihydroxypropyl](2-hydroxyethyl)amin...)
Affinity DataKd:  96nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPurine nucleoside phosphorylase(Bos taurus (bovine))
University Of Warsaw

Curated by ChEMBL
LigandPNGBDBM50200094(2-amino-1,9-dihydro-6H-purin-6-one | CHEMBL219568 ...)
Affinity DataKd:  120nMAssay Description:Binding affinity to calf recombinant PNP expressed in Escherichia coli BL21 (DE3) by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Albert Einstein College Of Medicine

Curated by ChEMBL
LigandPNGBDBM136309(US8853224, 27)
Affinity DataKd:  142nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Albert Einstein College Of Medicine

Curated by ChEMBL
LigandPNGBDBM136311(US8853224, 23)
Affinity DataKd:  159nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPurine nucleoside phosphorylase(Bos taurus (bovine))
University Of Warsaw

Curated by ChEMBL
LigandPNGBDBM50108005(2-Amino-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one ...)
Affinity DataKd:  160nMAssay Description:Binding affinity to calf recombinant PNP expressed in Escherichia coli BL21 (DE3) by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetPurine nucleoside phosphorylase(Bos taurus (bovine))
University Of Warsaw

Curated by ChEMBL
LigandPNGBDBM50200094(2-amino-1,9-dihydro-6H-purin-6-one | CHEMBL219568 ...)
Affinity DataKd:  160nMAssay Description:Binding affinity to calf recombinant PNP expressed in Escherichia coli BL21 (DE3) by fluorimetric titration analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Plasmodium falciparum)
Industrial Research

US Patent
LigandPNGBDBM50293064(7-({[1,3-Dihydroxy-2-(hydroxymethyl)propan-2-yl]am...)
Affinity DataKd:  163nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Albert Einstein College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50293079(7-({[(2S)-2,3-Dihydroxypropyl](2-hydroxyethyl)amin...)
Affinity DataKd:  165nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPurine nucleoside phosphorylase(Bos taurus (bovine))
University Of Warsaw

Curated by ChEMBL
LigandPNGBDBM50108005(2-Amino-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one ...)
Affinity DataKd:  170nMAssay Description:Binding affinity to calf recombinant PNP expressed in Escherichia coli BL21 (DE3) by fluorimetric titration analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetPurine nucleoside phosphorylase(Plasmodium falciparum)
Industrial Research

US Patent
LigandPNGBDBM50293067(7-({[(2S,3R)-1,3,4-Trihydroxybutan-2-yl]amino}meth...)
Affinity DataKd:  210nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPurine nucleoside phosphorylase(Plasmodium falciparum)
Industrial Research

US Patent
LigandPNGBDBM50293075(7-({[3-Hydroxy-2-(hydroxymethyl)propyl]amino}methy...)
Affinity DataKd:  210nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Albert Einstein College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50293083(7-({[(2R/S)-2,4-Dihydroxybutyl](methyl)amino}methy...)
Affinity DataKd:  227nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPurine nucleoside phosphorylase(Plasmodium falciparum)
Industrial Research

US Patent
LigandPNGBDBM50293071(7-({[(2S)-2,3-Dihydroxypropyl]amino}methyl)-3,5-di...)
Affinity DataKd:  260nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In DepthDetails US Patent
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