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Compile Data Set for Download or QSAR

Found 1495 hits Enz. Inhib. hit(s) with Target = 'cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM50365964
PNG
(CHEMBL1956235 | CHEMBL2070530)
Show SMILES COc1cc2nncc(-c3cnc(NC(C)C)c(C)c3)c2cc1OC
Show InChI InChI=1S/C19H22N4O2/c1-11(2)22-19-12(3)6-13(9-20-19)15-10-21-23-16-8-18(25-5)17(24-4)7-14(15)16/h6-11H,1-5H3,(H,20,22)
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n/an/an/a 0.940n/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Binding affinity to PDE10A in Sprague-Dawley rat striatum by TopCount analysis


J Med Chem 55: 4776-87 (2012)


Article DOI: 10.1021/jm3002372
BindingDB Entry DOI: 10.7270/Q2WM1FFG
More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM31592
PNG
(PF-2545920 | US9138494, MP-10 | substituted pyraz...)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2ccc3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C25H20N4O/c1-29-16-23(18-12-14-26-15-13-18)25(28-29)20-7-10-22(11-8-20)30-17-21-9-6-19-4-2-3-5-24(19)27-21/h2-16H,17H2,1H3
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0.170n/an/an/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]5-(6,7-dimethoxycinnolin-4-yl)-N-isopropyl-3-methylpyridin-2-amine from PDE10A in Sprague-Dawley rat striatum


J Med Chem 55: 4776-87 (2012)


Article DOI: 10.1021/jm3002372
BindingDB Entry DOI: 10.7270/Q2WM1FFG
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM50365964
PNG
(CHEMBL1956235 | CHEMBL2070530)
Show SMILES COc1cc2nncc(-c3cnc(NC(C)C)c(C)c3)c2cc1OC
Show InChI InChI=1S/C19H22N4O2/c1-11(2)22-19-12(3)6-13(9-20-19)15-10-21-23-16-8-18(25-5)17(24-4)7-14(15)16/h6-11H,1-5H3,(H,20,22)
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1.18n/an/an/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]5-(6,7-dimethoxycinnolin-4-yl)-N-isopropyl-3-methylpyridin-2-amine from PDE10A in Sprague-Dawley rat striatum


J Med Chem 55: 4776-87 (2012)


Article DOI: 10.1021/jm3002372
BindingDB Entry DOI: 10.7270/Q2WM1FFG
More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM14768
PNG
((R)-6,7-Dimethoxy-4-[3-(quinoxalin-2-yloxy)-pyrrol...)
Show SMILES COc1cc2ncnc(N3CC[C@H](C3)Oc3cnc4ccccc4n3)c2cc1OC
Show InChI InChI=1/C22H21N5O3/c1-28-19-9-15-18(10-20(19)29-2)24-13-25-22(15)27-8-7-14(12-27)30-21-11-23-16-5-3-4-6-17(16)26-21/h3-6,9-11,13-14H,7-8,12H2,1-2H3/t14-/s2
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4n/an/an/an/an/an/an/an/a



Pfizer Inc



Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...


J Med Chem 50: 182-5 (2007)


Article DOI: 10.1021/jm060653b
BindingDB Entry DOI: 10.7270/Q2930RDX
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM14760
PNG
((R)-6,7-Dimethoxy-4-[3-(naphthalen-2-yloxy)-pyrrol...)
Show SMILES COc1cc2ncnc(N3CC[C@H](C3)Oc3ccc4ccccc4c3)c2cc1OC
Show InChI InChI=1/C24H23N3O3/c1-28-22-12-20-21(13-23(22)29-2)25-15-26-24(20)27-10-9-19(14-27)30-18-8-7-16-5-3-4-6-17(16)11-18/h3-8,11-13,15,19H,9-10,14H2,1-2H3/t19-/s2
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12n/an/an/an/an/an/an/an/a



Pfizer Inc



Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...


J Med Chem 50: 182-5 (2007)


Article DOI: 10.1021/jm060653b
BindingDB Entry DOI: 10.7270/Q2930RDX
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM14766
PNG
((R)-6,7-Dimethoxy-4-[3-(quinolin-7-yloxy)-pyrrolid...)
Show SMILES COc1cc2ncnc(N3CC[C@H](C3)Oc3ccc4cccnc4c3)c2cc1OC
Show InChI InChI=1/C23H22N4O3/c1-28-21-11-18-20(12-22(21)29-2)25-14-26-23(18)27-9-7-17(13-27)30-16-6-5-15-4-3-8-24-19(15)10-16/h3-6,8,10-12,14,17H,7,9,13H2,1-2H3/t17-/s2
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12n/an/an/an/an/an/an/an/a



Pfizer Inc



Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...


J Med Chem 50: 182-5 (2007)


Article DOI: 10.1021/jm060653b
BindingDB Entry DOI: 10.7270/Q2930RDX
More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM14764
PNG
((R)-6,7-Dimethoxy-4-[3-(quinolin-6-yloxy)-pyrrolid...)
Show SMILES COc1cc2ncnc(N3CC[C@H](C3)Oc3ccc4ncccc4c3)c2cc1OC
Show InChI InChI=1/C23H22N4O3/c1-28-21-11-18-20(12-22(21)29-2)25-14-26-23(18)27-9-7-17(13-27)30-16-5-6-19-15(10-16)4-3-8-24-19/h3-6,8,10-12,14,17H,7,9,13H2,1-2H3/t17-/s2
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12n/an/an/an/an/an/an/an/a



Pfizer Inc



Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...


J Med Chem 50: 182-5 (2007)


Article DOI: 10.1021/jm060653b
BindingDB Entry DOI: 10.7270/Q2930RDX
More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM14763
PNG
((R)-6,7-Dimethoxy-4-[3-(7-methoxy-naphthalen-2-ylo...)
Show SMILES COc1ccc2ccc(O[C@@H]3CCN(C3)c3ncnc4cc(OC)c(OC)cc34)cc2c1
Show InChI InChI=1/C25H25N3O4/c1-29-18-6-4-16-5-7-19(11-17(16)10-18)32-20-8-9-28(14-20)25-21-12-23(30-2)24(31-3)13-22(21)26-15-27-25/h4-7,10-13,15,20H,8-9,14H2,1-3H3/t20-/s2
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17n/an/an/an/an/an/an/an/a



Pfizer Inc



Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...


J Med Chem 50: 182-5 (2007)


Article DOI: 10.1021/jm060653b
BindingDB Entry DOI: 10.7270/Q2930RDX
More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM14754
PNG
(1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-isoq...)
Show SMILES COc1ccc(Cc2nccc3cc(OC)c(OC)cc23)cc1OC
Show InChI InChI=1S/C20H21NO4/c1-22-17-6-5-13(10-18(17)23-2)9-16-15-12-20(25-4)19(24-3)11-14(15)7-8-21-16/h5-8,10-12H,9H2,1-4H3
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17 -43.9n/an/an/an/an/a7.522



Pfizer Inc



Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...


J Med Chem 50: 182-5 (2007)


Article DOI: 10.1021/jm060653b
BindingDB Entry DOI: 10.7270/Q2930RDX
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM14762
PNG
((R)-6,7-Dimethoxy-4-[3-(6-methoxy-naphthalen-2-ylo...)
Show SMILES COc1ccc2cc(O[C@@H]3CCN(C3)c3ncnc4cc(OC)c(OC)cc34)ccc2c1
Show InChI InChI=1/C25H25N3O4/c1-29-18-6-4-17-11-19(7-5-16(17)10-18)32-20-8-9-28(14-20)25-21-12-23(30-2)24(31-3)13-22(21)26-15-27-25/h4-7,10-13,15,20H,8-9,14H2,1-3H3/t20-/s2
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18n/an/an/an/an/an/an/an/a



Pfizer Inc



Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...


J Med Chem 50: 182-5 (2007)


Article DOI: 10.1021/jm060653b
BindingDB Entry DOI: 10.7270/Q2930RDX
More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM14765
PNG
((R)-6,7-Dimethoxy-4-[3-(2-methyl-quinolin-6-yloxy)...)
Show SMILES COc1cc2ncnc(N3CC[C@H](C3)Oc3ccc4nc(C)ccc4c3)c2cc1OC
Show InChI InChI=1/C24H24N4O3/c1-15-4-5-16-10-17(6-7-20(16)27-15)31-18-8-9-28(13-18)24-19-11-22(29-2)23(30-3)12-21(19)25-14-26-24/h4-7,10-12,14,18H,8-9,13H2,1-3H3/t18-/s2
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18n/an/an/an/an/an/an/an/a



Pfizer Inc



Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...


J Med Chem 50: 182-5 (2007)


Article DOI: 10.1021/jm060653b
BindingDB Entry DOI: 10.7270/Q2930RDX
More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM14767
PNG
((R)-4-[3-(Isoquinolin-3-yloxy)-pyrrolidin-1-yl]-6,...)
Show SMILES COc1cc2ncnc(N3CC[C@H](C3)Oc3cc4ccccc4cn3)c2cc1OC
Show InChI InChI=1/C23H22N4O3/c1-28-20-10-18-19(11-21(20)29-2)25-14-26-23(18)27-8-7-17(13-27)30-22-9-15-5-3-4-6-16(15)12-24-22/h3-6,9-12,14,17H,7-8,13H2,1-2H3/t17-/s2
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19n/an/an/an/an/an/an/an/a



Pfizer Inc



Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...


J Med Chem 50: 182-5 (2007)


Article DOI: 10.1021/jm060653b
BindingDB Entry DOI: 10.7270/Q2930RDX
More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM14755
PNG
(6,7-dimethoxy-4-[8-(4-methylpiperazin-1-yl)sulfony...)
Show SMILES COc1cc2ncnc(N3CCc4cccc(c4C3)S(=O)(=O)N3CCN(C)CC3)c2cc1OC
Show InChI InChI=1S/C24H29N5O4S/c1-27-9-11-29(12-10-27)34(30,31)23-6-4-5-17-7-8-28(15-19(17)23)24-18-13-21(32-2)22(33-3)14-20(18)25-16-26-24/h4-6,13-14,16H,7-12,15H2,1-3H3
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25 -43.0n/an/an/an/an/a7.522



Pfizer Inc



Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...


J Med Chem 50: 182-5 (2007)


Article DOI: 10.1021/jm060653b
BindingDB Entry DOI: 10.7270/Q2930RDX
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM14756
PNG
((R)-4-[3-(5-Chloro-pyrimidin-2-yloxy)-pyrrolidin-1...)
Show SMILES COc1cc2ncnc(N3CC[C@H](C3)Oc3ncc(Cl)cn3)c2cc1OC
Show InChI InChI=1/C18H18ClN5O3/c1-25-15-5-13-14(6-16(15)26-2)22-10-23-17(13)24-4-3-12(9-24)27-18-20-7-11(19)8-21-18/h5-8,10,12H,3-4,9H2,1-2H3/t12-/s2
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44n/an/an/an/an/an/an/an/a



Pfizer Inc



Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...


J Med Chem 50: 182-5 (2007)


Article DOI: 10.1021/jm060653b
BindingDB Entry DOI: 10.7270/Q2930RDX
More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM14748
PNG
((R)-4-[3-(4-Ethoxy-phenoxy)-pyrrolidin-1-yl]-6,7-d...)
Show SMILES CCOc1ccc(O[C@@H]2CCN(C2)c2ncnc3cc(OC)c(OC)cc23)cc1
Show InChI InChI=1/C22H25N3O4/c1-4-28-15-5-7-16(8-6-15)29-17-9-10-25(13-17)22-18-11-20(26-2)21(27-3)12-19(18)23-14-24-22/h5-8,11-12,14,17H,4,9-10,13H2,1-3H3/t17-/s2
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54 -41.1n/an/an/an/an/a7.522



Pfizer Inc



Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...


J Med Chem 50: 182-5 (2007)


Article DOI: 10.1021/jm060653b
BindingDB Entry DOI: 10.7270/Q2930RDX
More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM14745
PNG
((R)-4-[1-(6,7-Dimethoxy-quinazolin-4-yl)-pyrrolidi...)
Show SMILES COc1cc2ncnc(N3CC[C@H](C3)Oc3ccc(cc3)C#N)c2cc1OC
Show InChI InChI=1/C21H20N4O3/c1-26-19-9-17-18(10-20(19)27-2)23-13-24-21(17)25-8-7-16(12-25)28-15-5-3-14(11-22)4-6-15/h3-6,9-10,13,16H,7-8,12H2,1-2H3/t16-/s2
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56 -41.0n/an/an/an/an/a7.522



Pfizer Inc



Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...


J Med Chem 50: 182-5 (2007)


Article DOI: 10.1021/jm060653b
BindingDB Entry DOI: 10.7270/Q2930RDX
More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM14753
PNG
((R)-4-[3-(3,4-Dimethoxy-phenoxy)-pyrrolidin-1-yl]-...)
Show SMILES COc1ccc(O[C@@H]2CCN(C2)c2ncnc3cc(OC)c(OC)cc23)cc1OC
Show InChI InChI=1/C22H25N3O5/c1-26-18-6-5-14(9-19(18)27-2)30-15-7-8-25(12-15)22-16-10-20(28-3)21(29-4)11-17(16)23-13-24-22/h5-6,9-11,13,15H,7-8,12H2,1-4H3/t15-/s2
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67 -40.5n/an/an/an/an/a7.522



Pfizer Inc



Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...


J Med Chem 50: 182-5 (2007)


Article DOI: 10.1021/jm060653b
BindingDB Entry DOI: 10.7270/Q2930RDX
More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM14752
PNG
((R)-4-[3-(Indan-5-yloxy)-pyrrolidin-1-yl]-6,7-dime...)
Show SMILES COc1cc2ncnc(N3CC[C@H](C3)Oc3ccc4CCCc4c3)c2cc1OC
Show InChI InChI=1/C23H25N3O3/c1-27-21-11-19-20(12-22(21)28-2)24-14-25-23(19)26-9-8-18(13-26)29-17-7-6-15-4-3-5-16(15)10-17/h6-7,10-12,14,18H,3-5,8-9,13H2,1-2H3/t18-/s2
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68 -40.5n/an/an/an/an/a7.522



Pfizer Inc



Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...


J Med Chem 50: 182-5 (2007)


Article DOI: 10.1021/jm060653b
BindingDB Entry DOI: 10.7270/Q2930RDX
More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM14751
PNG
((R)-4-[3-(3-Ethoxy-phenoxy)-pyrrolidin-1-yl]-6,7-d...)
Show SMILES CCOc1cccc(O[C@@H]2CCN(C2)c2ncnc3cc(OC)c(OC)cc23)c1
Show InChI InChI=1/C22H25N3O4/c1-4-28-15-6-5-7-16(10-15)29-17-8-9-25(13-17)22-18-11-20(26-2)21(27-3)12-19(18)23-14-24-22/h5-7,10-12,14,17H,4,8-9,13H2,1-3H3/t17-/s2
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94 -39.7n/an/an/an/an/a7.522



Pfizer Inc



Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...


J Med Chem 50: 182-5 (2007)


Article DOI: 10.1021/jm060653b
BindingDB Entry DOI: 10.7270/Q2930RDX
More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM14747
PNG
((R)-4-[3-(4-tert-Butyl-phenoxy)-pyrrolidin-1-yl]-6...)
Show SMILES COc1cc2ncnc(N3CC[C@H](C3)Oc3ccc(cc3)C(C)(C)C)c2cc1OC
Show InChI InChI=1/C24H29N3O3/c1-24(2,3)16-6-8-17(9-7-16)30-18-10-11-27(14-18)23-19-12-21(28-4)22(29-5)13-20(19)25-15-26-23/h6-9,12-13,15,18H,10-11,14H2,1-5H3/t18-/s2
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100 -39.6n/an/an/an/an/a7.522



Pfizer Inc



Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...


J Med Chem 50: 182-5 (2007)


Article DOI: 10.1021/jm060653b
BindingDB Entry DOI: 10.7270/Q2930RDX
More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM14759
PNG
((R)-6,7-Dimethoxy-4-[3-(pyridin-4-yloxy)-pyrrolidi...)
Show SMILES COc1cc2ncnc(N3CC[C@H](C3)Oc3ccncc3)c2cc1OC
Show InChI InChI=1/C19H20N4O3/c1-24-17-9-15-16(10-18(17)25-2)21-12-22-19(15)23-8-5-14(11-23)26-13-3-6-20-7-4-13/h3-4,6-7,9-10,12,14H,5,8,11H2,1-2H3/t14-/s2
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112n/an/an/an/an/an/an/an/a



Pfizer Inc



Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...


J Med Chem 50: 182-5 (2007)


Article DOI: 10.1021/jm060653b
BindingDB Entry DOI: 10.7270/Q2930RDX
More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM14757
PNG
((R)-6,7-Dimethoxy-4-[3-(pyridin-2-yloxy)-pyrrolidi...)
Show SMILES COc1cc2ncnc(N3CC[C@H](C3)Oc3ccccn3)c2cc1OC
Show InChI InChI=1/C19H20N4O3/c1-24-16-9-14-15(10-17(16)25-2)21-12-22-19(14)23-8-6-13(11-23)26-18-5-3-4-7-20-18/h3-5,7,9-10,12-13H,6,8,11H2,1-2H3/t13-/s2
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123n/an/an/an/an/an/an/an/a



Pfizer Inc



Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...


J Med Chem 50: 182-5 (2007)


Article DOI: 10.1021/jm060653b
BindingDB Entry DOI: 10.7270/Q2930RDX
More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM14758
PNG
((R)-6,7-Dimethoxy-4-[3-(pyridin-3-yloxy)-pyrrolidi...)
Show SMILES COc1cc2ncnc(N3CC[C@H](C3)Oc3cccnc3)c2cc1OC
Show InChI InChI=1/C19H20N4O3/c1-24-17-8-15-16(9-18(17)25-2)21-12-22-19(15)23-7-5-14(11-23)26-13-4-3-6-20-10-13/h3-4,6,8-10,12,14H,5,7,11H2,1-2H3/t14-/s2
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128n/an/an/an/an/an/an/an/a



Pfizer Inc



Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...


J Med Chem 50: 182-5 (2007)


Article DOI: 10.1021/jm060653b
BindingDB Entry DOI: 10.7270/Q2930RDX
More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM14744
PNG
((R)-2-[1-(6,7-Dimethoxy-quinazolin-4-yl)-pyrrolidi...)
Show SMILES COc1cc2ncnc(N3CC[C@H](C3)Oc3ccccc3C#N)c2cc1OC
Show InChI InChI=1/C21H20N4O3/c1-26-19-9-16-17(10-20(19)27-2)23-13-24-21(16)25-8-7-15(12-25)28-18-6-4-3-5-14(18)11-22/h3-6,9-10,13,15H,7-8,12H2,1-2H3/t15-/s2
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130 -38.9n/an/an/an/an/a7.522



Pfizer Inc



Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...


J Med Chem 50: 182-5 (2007)


Article DOI: 10.1021/jm060653b
BindingDB Entry DOI: 10.7270/Q2930RDX
More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM14750
PNG
((R)-4-[3-(Biphenyl-3-yloxy)-pyrrolidin-1-yl]-6,7-d...)
Show SMILES COc1cc2ncnc(N3CC[C@H](C3)Oc3cccc(c3)-c3ccccc3)c2cc1OC
Show InChI InChI=1/C26H25N3O3/c1-30-24-14-22-23(15-25(24)31-2)27-17-28-26(22)29-12-11-21(16-29)32-20-10-6-9-19(13-20)18-7-4-3-5-8-18/h3-10,13-15,17,21H,11-12,16H2,1-2H3/t21-/s2
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136 -38.8n/an/an/an/an/a7.522



Pfizer Inc



Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...


J Med Chem 50: 182-5 (2007)


Article DOI: 10.1021/jm060653b
BindingDB Entry DOI: 10.7270/Q2930RDX
More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM14749
PNG
((R)-4-[3-(3-Isopropyl-phenoxy)-pyrrolidin-1-yl]-6,...)
Show SMILES COc1cc2ncnc(N3CC[C@H](C3)Oc3cccc(c3)C(C)C)c2cc1OC
Show InChI InChI=1/C23H27N3O3/c1-15(2)16-6-5-7-17(10-16)29-18-8-9-26(13-18)23-19-11-21(27-3)22(28-4)12-20(19)24-14-25-23/h5-7,10-12,14-15,18H,8-9,13H2,1-4H3/t18-/s2
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171 -38.2n/an/an/an/an/a7.522



Pfizer Inc



Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...


J Med Chem 50: 182-5 (2007)


Article DOI: 10.1021/jm060653b
BindingDB Entry DOI: 10.7270/Q2930RDX
More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM14746
PNG
((R)-6,7-Dimethoxy-4-[3-(4-trifluoromethoxy-phenoxy...)
Show SMILES COc1cc2ncnc(N3CC[C@H](C3)Oc3ccc(OC(F)(F)F)cc3)c2cc1OC
Show InChI InChI=1/C21H20F3N3O4/c1-28-18-9-16-17(10-19(18)29-2)25-12-26-20(16)27-8-7-15(11-27)30-13-3-5-14(6-4-13)31-21(22,23)24/h3-6,9-10,12,15H,7-8,11H2,1-2H3/t15-/s2
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185 -38.0n/an/an/an/an/a7.522



Pfizer Inc



Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...


J Med Chem 50: 182-5 (2007)


Article DOI: 10.1021/jm060653b
BindingDB Entry DOI: 10.7270/Q2930RDX
More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM14743
PNG
((R)-4-[3-(2-Chloro-phenoxy)-pyrrolidin-1-yl]-6,7-d...)
Show SMILES COc1cc2ncnc(N3CC[C@H](C3)Oc3ccccc3Cl)c2cc1OC
Show InChI InChI=1/C20H20ClN3O3/c1-25-18-9-14-16(10-19(18)26-2)22-12-23-20(14)24-8-7-13(11-24)27-17-6-4-3-5-15(17)21/h3-6,9-10,12-13H,7-8,11H2,1-2H3/t13-/s2
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198 -37.9n/an/an/an/an/a7.522



Pfizer Inc



Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...


J Med Chem 50: 182-5 (2007)


Article DOI: 10.1021/jm060653b
BindingDB Entry DOI: 10.7270/Q2930RDX
More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM14761
PNG
((R)-6,7-Dimethoxy-4-[3-(naphthalen-1-yloxy)-pyrrol...)
Show SMILES COc1cc2ncnc(N3CC[C@H](C3)Oc3cccc4ccccc34)c2cc1OC
Show InChI InChI=1/C24H23N3O3/c1-28-22-12-19-20(13-23(22)29-2)25-15-26-24(19)27-11-10-17(14-27)30-21-9-5-7-16-6-3-4-8-18(16)21/h3-9,12-13,15,17H,10-11,14H2,1-2H3/t17-/s2
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210n/an/an/an/an/an/an/an/a



Pfizer Inc



Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...


J Med Chem 50: 182-5 (2007)


Article DOI: 10.1021/jm060653b
BindingDB Entry DOI: 10.7270/Q2930RDX
More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM14741
PNG
((R)-6,7-Dimethoxy-4-[3-(2-methoxy-phenoxy)-pyrroli...)
Show SMILES COc1ccccc1O[C@@H]1CCN(C1)c1ncnc2cc(OC)c(OC)cc12
Show InChI InChI=1/C21H23N3O4/c1-25-17-6-4-5-7-18(17)28-14-8-9-24(12-14)21-15-10-19(26-2)20(27-3)11-16(15)22-13-23-21/h4-7,10-11,13-14H,8-9,12H2,1-3H3/t14-/s2
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240 -37.4n/an/an/an/an/a7.522



Pfizer Inc



Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...


J Med Chem 50: 182-5 (2007)


Article DOI: 10.1021/jm060653b
BindingDB Entry DOI: 10.7270/Q2930RDX
More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM14740
PNG
((R)-6,7-Dimethoxy-4-(3-o-tolyloxy-pyrrolidin-1-yl)...)
Show SMILES COc1cc2ncnc(N3CC[C@H](C3)Oc3ccccc3C)c2cc1OC
Show InChI InChI=1/C21H23N3O3/c1-14-6-4-5-7-18(14)27-15-8-9-24(12-15)21-16-10-19(25-2)20(26-3)11-17(16)22-13-23-21/h4-7,10-11,13,15H,8-9,12H2,1-3H3/t15-/s2
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326 -36.7n/an/an/an/an/a7.522



Pfizer Inc



Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...


J Med Chem 50: 182-5 (2007)


Article DOI: 10.1021/jm060653b
BindingDB Entry DOI: 10.7270/Q2930RDX
More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM14742
PNG
((S)-6,7-Dimethoxy-4-[3-(2-methoxy-phenoxy)-pyrroli...)
Show SMILES COc1ccccc1O[C@H]1CCN(C1)c1ncnc2cc(OC)c(OC)cc12
Show InChI InChI=1/C21H23N3O4/c1-25-17-6-4-5-7-18(17)28-14-8-9-24(12-14)21-15-10-19(26-2)20(27-3)11-16(15)22-13-23-21/h4-7,10-11,13-14H,8-9,12H2,1-3H3/t14-/s2
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641 -35.0n/an/an/an/an/a7.522



Pfizer Inc



Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...


J Med Chem 50: 182-5 (2007)


Article DOI: 10.1021/jm060653b
BindingDB Entry DOI: 10.7270/Q2930RDX
More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM14739
PNG
((R)-6,7-Dimethoxy-4-[3-(2-trifluoromethyl-phenoxy)...)
Show SMILES COc1cc2ncnc(N3CC[C@H](C3)Oc3ccccc3C(F)(F)F)c2cc1OC
Show InChI InChI=1/C21H20F3N3O3/c1-28-18-9-14-16(10-19(18)29-2)25-12-26-20(14)27-8-7-13(11-27)30-17-6-4-3-5-15(17)21(22,23)24/h3-6,9-10,12-13H,7-8,11H2,1-2H3/t13-/s2
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811 -34.4n/an/an/an/an/a7.522



Pfizer Inc



Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...


J Med Chem 50: 182-5 (2007)


Article DOI: 10.1021/jm060653b
BindingDB Entry DOI: 10.7270/Q2930RDX
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50348327
PNG
(CHEMBL1800817)
Show SMILES COc1ccc(\C=N\NC(=O)CSc2cc(C)nc3ccccc23)cc1OC
Show InChI InChI=1S/C21H21N3O3S/c1-14-10-20(16-6-4-5-7-17(16)23-14)28-13-21(25)24-22-12-15-8-9-18(26-2)19(11-15)27-3/h4-12H,13H2,1-3H3,(H,24,25)/b22-12+
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n/an/a 49n/an/an/an/an/an/a



Omeros Corp.

Curated by ChEMBL


Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting


Bioorg Med Chem Lett 21: 4155-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.05.100
BindingDB Entry DOI: 10.7270/Q2CJ8FRT
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50348328
PNG
(CHEMBL1800240)
Show SMILES COc1cc(\C=N\N(C)C(=O)CSc2cc(C)nc3ccccc23)cc(OC)c1OC
Show InChI InChI=1S/C23H25N3O4S/c1-15-10-21(17-8-6-7-9-18(17)25-15)31-14-22(27)26(2)24-13-16-11-19(28-3)23(30-5)20(12-16)29-4/h6-13H,14H2,1-5H3/b24-13+
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n/an/a 26n/an/an/an/an/an/a



Omeros Corp.

Curated by ChEMBL


Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting


Bioorg Med Chem Lett 21: 4155-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.05.100
BindingDB Entry DOI: 10.7270/Q2CJ8FRT
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50348329
PNG
(CHEMBL1800239)
Show SMILES COc1cc(\C=N\NC(=O)CN(C)c2cc(C)nc3ccccc23)cc(OC)c1OC
Show InChI InChI=1S/C23H26N4O4/c1-15-10-19(17-8-6-7-9-18(17)25-15)27(2)14-22(28)26-24-13-16-11-20(29-3)23(31-5)21(12-16)30-4/h6-13H,14H2,1-5H3,(H,26,28)/b24-13+
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n/an/a 360n/an/an/an/an/an/a



Omeros Corp.

Curated by ChEMBL


Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting


Bioorg Med Chem Lett 21: 4155-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.05.100
BindingDB Entry DOI: 10.7270/Q2CJ8FRT
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50348330
PNG
(CHEMBL1800238)
Show SMILES COc1ccc(cc1OC)C(C)=NNC(=O)CSc1cc(C)nc2ccccc12
Show InChI InChI=1S/C22H23N3O3S/c1-14-11-21(17-7-5-6-8-18(17)23-14)29-13-22(26)25-24-15(2)16-9-10-19(27-3)20(12-16)28-4/h5-12H,13H2,1-4H3,(H,25,26)/b24-15+
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n/an/a 180n/an/an/an/an/an/a



Omeros Corp.

Curated by ChEMBL


Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting


Bioorg Med Chem Lett 21: 4155-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.05.100
BindingDB Entry DOI: 10.7270/Q2CJ8FRT
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50348331
PNG
(CHEMBL1800077)
Show SMILES COc1ccc(\C=N\NC(=O)CNc2cc(C)nc3ccccc23)cc1OC
Show InChI InChI=1S/C21H22N4O3/c1-14-10-18(16-6-4-5-7-17(16)24-14)22-13-21(26)25-23-12-15-8-9-19(27-2)20(11-15)28-3/h4-12H,13H2,1-3H3,(H,22,24)(H,25,26)/b23-12+
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n/an/a 8.00E+3n/an/an/an/an/an/a



Omeros Corp.

Curated by ChEMBL


Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting


Bioorg Med Chem Lett 21: 4155-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.05.100
BindingDB Entry DOI: 10.7270/Q2CJ8FRT
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50348332
PNG
(CHEMBL1800237)
Show SMILES COc1ccc(\C=N\NC(=O)COc2cc(C)nc3ccccc23)cc1OC
Show InChI InChI=1S/C21H21N3O4/c1-14-10-19(16-6-4-5-7-17(16)23-14)28-13-21(25)24-22-12-15-8-9-18(26-2)20(11-15)27-3/h4-12H,13H2,1-3H3,(H,24,25)/b22-12+
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n/an/a 1.60E+3n/an/an/an/an/an/a



Omeros Corp.

Curated by ChEMBL


Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting


Bioorg Med Chem Lett 21: 4155-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.05.100
BindingDB Entry DOI: 10.7270/Q2CJ8FRT
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50348333
PNG
(CHEMBL1800236)
Show SMILES COc1ccc2nc(C)cc(SCC(=O)N\N=C\c3cc(OC)c(OC)c(OC)c3)c2c1
Show InChI InChI=1S/C23H25N3O5S/c1-14-8-21(17-11-16(28-2)6-7-18(17)25-14)32-13-22(27)26-24-12-15-9-19(29-3)23(31-5)20(10-15)30-4/h6-12H,13H2,1-5H3,(H,26,27)/b24-12+
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n/an/a 8n/an/an/an/an/an/a



Omeros Corp.

Curated by ChEMBL


Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting


Bioorg Med Chem Lett 21: 4155-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.05.100
BindingDB Entry DOI: 10.7270/Q2CJ8FRT
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50348334
PNG
(CHEMBL1800235)
Show SMILES COc1cc(\C=N\NC(=O)CSc2ccnc3cc(Cl)ccc23)cc(OC)c1OC
Show InChI InChI=1S/C21H20ClN3O4S/c1-27-17-8-13(9-18(28-2)21(17)29-3)11-24-25-20(26)12-30-19-6-7-23-16-10-14(22)4-5-15(16)19/h4-11H,12H2,1-3H3,(H,25,26)/b24-11+
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n/an/a 28n/an/an/an/an/an/a



Omeros Corp.

Curated by ChEMBL


Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting


Bioorg Med Chem Lett 21: 4155-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.05.100
BindingDB Entry DOI: 10.7270/Q2CJ8FRT
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50348335
PNG
(CHEMBL1800234)
Show SMILES COc1cc(\C=N\NC(=O)CSc2ccnc3ccccc23)cc(OC)c1OC
Show InChI InChI=1S/C21H21N3O4S/c1-26-17-10-14(11-18(27-2)21(17)28-3)12-23-24-20(25)13-29-19-8-9-22-16-7-5-4-6-15(16)19/h4-12H,13H2,1-3H3,(H,24,25)/b23-12+
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n/an/a 24n/an/an/an/an/an/a



Omeros Corp.

Curated by ChEMBL


Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting


Bioorg Med Chem Lett 21: 4155-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.05.100
BindingDB Entry DOI: 10.7270/Q2CJ8FRT
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50348336
PNG
(CHEMBL1800233)
Show SMILES COc1cc(\C=N\NC(=O)CSc2ccc([N+]([O-])=O)c3ccccc23)cc(OC)c1OC
Show InChI InChI=1S/C22H21N3O6S/c1-29-18-10-14(11-19(30-2)22(18)31-3)12-23-24-21(26)13-32-20-9-8-17(25(27)28)15-6-4-5-7-16(15)20/h4-12H,13H2,1-3H3,(H,24,26)/b23-12+
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n/an/a 100n/an/an/an/an/an/a



Omeros Corp.

Curated by ChEMBL


Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting


Bioorg Med Chem Lett 21: 4155-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.05.100
BindingDB Entry DOI: 10.7270/Q2CJ8FRT
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50348337
PNG
(CHEMBL1800232)
Show SMILES COc1cc(\C=N\NC(=O)CSc2ccc3ccccc3n2)cc(OC)c1OC
Show InChI InChI=1S/C21H21N3O4S/c1-26-17-10-14(11-18(27-2)21(17)28-3)12-22-24-19(25)13-29-20-9-8-15-6-4-5-7-16(15)23-20/h4-12H,13H2,1-3H3,(H,24,25)/b22-12+
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n/an/a 140n/an/an/an/an/an/a



Omeros Corp.

Curated by ChEMBL


Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting


Bioorg Med Chem Lett 21: 4155-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.05.100
BindingDB Entry DOI: 10.7270/Q2CJ8FRT
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50348338
PNG
(CHEMBL1800231)
Show SMILES COc1cc(\C=N\NC(=O)CSc2cccc3cccnc23)cc(OC)c1OC
Show InChI InChI=1S/C21H21N3O4S/c1-26-16-10-14(11-17(27-2)21(16)28-3)12-23-24-19(25)13-29-18-8-4-6-15-7-5-9-22-20(15)18/h4-12H,13H2,1-3H3,(H,24,25)/b23-12+
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n/an/a 190n/an/an/an/an/an/a



Omeros Corp.

Curated by ChEMBL


Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting


Bioorg Med Chem Lett 21: 4155-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.05.100
BindingDB Entry DOI: 10.7270/Q2CJ8FRT
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50348339
PNG
(CHEMBL1800230)
Show SMILES COc1cc(\C=N\NC(=O)CSc2ccc(cc2)-c2ccccc2)cc(OC)c1OC
Show InChI InChI=1S/C24H24N2O4S/c1-28-21-13-17(14-22(29-2)24(21)30-3)15-25-26-23(27)16-31-20-11-9-19(10-12-20)18-7-5-4-6-8-18/h4-15H,16H2,1-3H3,(H,26,27)/b25-15+
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n/an/a 260n/an/an/an/an/an/a



Omeros Corp.

Curated by ChEMBL


Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting


Bioorg Med Chem Lett 21: 4155-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.05.100
BindingDB Entry DOI: 10.7270/Q2CJ8FRT
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50348340
PNG
(CHEMBL1800229)
Show SMILES COc1cc(\C=N\NC(=O)CSc2ccncc2)cc(OC)c1OC
Show InChI InChI=1S/C17H19N3O4S/c1-22-14-8-12(9-15(23-2)17(14)24-3)10-19-20-16(21)11-25-13-4-6-18-7-5-13/h4-10H,11H2,1-3H3,(H,20,21)/b19-10+
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n/an/a 550n/an/an/an/an/an/a



Omeros Corp.

Curated by ChEMBL


Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting


Bioorg Med Chem Lett 21: 4155-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.05.100
BindingDB Entry DOI: 10.7270/Q2CJ8FRT
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50348341
PNG
(CHEMBL1800316)
Show SMILES COc1ccccc1SCC(=O)N\N=C\c1cc(OC)c(OC)c(OC)c1
Show InChI InChI=1S/C19H22N2O5S/c1-23-14-7-5-6-8-17(14)27-12-18(22)21-20-11-13-9-15(24-2)19(26-4)16(10-13)25-3/h5-11H,12H2,1-4H3,(H,21,22)/b20-11+
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n/an/a 660n/an/an/an/an/an/a



Omeros Corp.

Curated by ChEMBL


Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting


Bioorg Med Chem Lett 21: 4155-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.05.100
BindingDB Entry DOI: 10.7270/Q2CJ8FRT
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50348343
PNG
(CHEMBL1800314)
Show SMILES COc1cc(\C=N\NC(=O)CSc2ccncn2)cc(OC)c1OC
Show InChI InChI=1S/C16H18N4O4S/c1-22-12-6-11(7-13(23-2)16(12)24-3)8-19-20-14(21)9-25-15-4-5-17-10-18-15/h4-8,10H,9H2,1-3H3,(H,20,21)/b19-8+
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n/an/a 1.07E+3n/an/an/an/an/an/a



Omeros Corp.

Curated by ChEMBL


Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting


Bioorg Med Chem Lett 21: 4155-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.05.100
BindingDB Entry DOI: 10.7270/Q2CJ8FRT
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50348344
PNG
(CHEMBL1800313)
Show SMILES COc1cc(\C=N\NC(=O)CSc2cc(C)nc3ccccc23)cc(OC)c1Br
Show InChI InChI=1S/C21H20BrN3O3S/c1-13-8-19(15-6-4-5-7-16(15)24-13)29-12-20(26)25-23-11-14-9-17(27-2)21(22)18(10-14)28-3/h4-11H,12H2,1-3H3,(H,25,26)/b23-11+
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n/an/a 4.80n/an/an/an/an/an/a



Omeros Corp.

Curated by ChEMBL


Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting


Bioorg Med Chem Lett 21: 4155-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.05.100
BindingDB Entry DOI: 10.7270/Q2CJ8FRT
More data for this
Ligand-Target Pair
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