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Found 806 hits Enz. Inhib. hit(s) with Target = '3-phosphoinositide-dependent protein kinase 1 (aa 51-359)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
3-phosphoinositide-dependent protein kinase 1 (aa 51-359)


(Homo sapiens (Human))
BDBM17054
PNG
((2S,3R,4R,6R,18R)-18-hydroxy-3-methoxy-2-methyl-4-...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4[C@@H](O)NC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O4/c1-28-25(35-3)15(29-2)12-18(36-28)31-16-10-6-4-8-13(16)19-21-22(27(34)30-26(21)33)20-14-9-5-7-11-17(14)32(28)24(20)23(19)31/h4-11,15,18,25,27,29,34H,12H2,1-3H3,(H,30,33)/t15-,18-,25-,27-,28+/m1/s1
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n/an/a 5n/an/an/an/a7.530



University of Dundee



Assay Description
In vitro PDK1 assay using purified enzyme, was incubated with substrate PDKtide, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P inco...


Biochem J 375: 255-62 (2003)


Article DOI: 10.1042/BJ20031119
BindingDB Entry DOI: 10.7270/Q2X928JB
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
3-phosphoinositide-dependent protein kinase 1 (aa 51-359)


(Homo sapiens (Human))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a 6.5n/an/an/an/a7.530



University of Dundee



Assay Description
In vitro PDK1 assay using purified enzyme, was incubated with substrate PDKtide, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P inco...


Biochem J 375: 255-62 (2003)


Article DOI: 10.1042/BJ20031119
BindingDB Entry DOI: 10.7270/Q2X928JB
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
3-phosphoinositide-dependent protein kinase 1 (aa 51-359)


(Homo sapiens (Human))
BDBM17055
PNG
((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...)
Show SMILES CN(C)C[C@@H]1CCn2cc(C3=C(C(=O)NC3=O)c3cn(CCO1)c1ccccc31)c1ccccc21
Show InChI InChI=1S/C28H28N4O3/c1-30(2)15-18-11-12-31-16-21(19-7-3-5-9-23(19)31)25-26(28(34)29-27(25)33)22-17-32(13-14-35-18)24-10-6-4-8-20(22)24/h3-10,16-18H,11-15H2,1-2H3,(H,29,33,34)/t18-/m0/s1
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n/an/a 750n/an/an/an/a7.530



University of Dundee



Assay Description
In vitro PDK1 assay using purified enzyme, was incubated with substrate PDKtide, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P inco...


Structure 12: 215-26 (2004)


Article DOI: 10.1016/j.str.2004.01.005
BindingDB Entry DOI: 10.7270/Q2SJ1HV2
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
3-phosphoinositide-dependent protein kinase 1 (aa 51-359)


(Homo sapiens (Human))
BDBM2683
PNG
(2-[1-(3-dimethylaminopropyl)-indol-3-yl]-3-(indol-...)
Show SMILES CN(C)CCCn1cc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc12
Show InChI InChI=1S/C25H24N4O2/c1-28(2)12-7-13-29-15-19(17-9-4-6-11-21(17)29)23-22(24(30)27-25(23)31)18-14-26-20-10-5-3-8-16(18)20/h3-6,8-11,14-15,26H,7,12-13H2,1-2H3,(H,27,30,31)
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n/an/a 9.00E+3n/an/an/an/a7.530



University of Dundee



Assay Description
In vitro PDK1 assay using purified enzyme, was incubated with substrate PDKtide, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P inco...


Structure 12: 215-26 (2004)


Article DOI: 10.1016/j.str.2004.01.005
BindingDB Entry DOI: 10.7270/Q2SJ1HV2
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
3-phosphoinositide-dependent protein kinase 1 (aa 51-359)


(Homo sapiens (Human))
BDBM2694
PNG
(3-(1H-indol-3-yl)-4-{1-[2-(1-methylpyrrolidin-2-yl...)
Show SMILES CN1CCCC1CCn1cc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc12
Show InChI InChI=1S/C27H26N4O2/c1-30-13-6-7-17(30)12-14-31-16-21(19-9-3-5-11-23(19)31)25-24(26(32)29-27(25)33)20-15-28-22-10-4-2-8-18(20)22/h2-5,8-11,15-17,28H,6-7,12-14H2,1H3,(H,29,32,33)
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n/an/a 1.40E+4n/an/an/an/a7.530



University of Dundee



Assay Description
In vitro PDK1 assay using purified enzyme, was incubated with substrate PDKtide, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P inco...


Structure 12: 215-26 (2004)


Article DOI: 10.1016/j.str.2004.01.005
BindingDB Entry DOI: 10.7270/Q2SJ1HV2
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
3-phosphoinositide-dependent protein kinase 1 (aa 51-359)


(Homo sapiens (Human))
BDBM2691
PNG
(3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1H-indol-3-...)
Show SMILES NCCCn1cc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc12
Show InChI InChI=1S/C23H20N4O2/c24-10-5-11-27-13-17(15-7-2-4-9-19(15)27)21-20(22(28)26-23(21)29)16-12-25-18-8-3-1-6-14(16)18/h1-4,6-9,12-13,25H,5,10-11,24H2,(H,26,28,29)
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n/an/a 4.00E+3n/an/an/an/a7.530



University of Dundee



Assay Description
In vitro PDK1 assay using purified enzyme, was incubated with substrate PDKtide, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P inco...


Structure 12: 215-26 (2004)


Article DOI: 10.1016/j.str.2004.01.005
BindingDB Entry DOI: 10.7270/Q2SJ1HV2
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
3-phosphoinositide-dependent protein kinase 1 (aa 51-359)


(Homo sapiens (Human))
BDBM2695
PNG
(3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1-methyl-1H...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cn(CCCN)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C24H22N4O2/c1-27-13-17(15-7-2-4-9-19(15)27)21-22(24(30)26-23(21)29)18-14-28(12-6-11-25)20-10-5-3-8-16(18)20/h2-5,7-10,13-14H,6,11-12,25H2,1H3,(H,26,29,30)
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n/an/a 1.00E+3n/an/an/an/a7.530



University of Dundee



Assay Description
In vitro PDK1 assay using purified enzyme, was incubated with substrate PDKtide, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P inco...


Structure 12: 215-26 (2004)


Article DOI: 10.1016/j.str.2004.01.005
BindingDB Entry DOI: 10.7270/Q2SJ1HV2
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
3-phosphoinositide-dependent protein kinase 1 (aa 51-359)


(Homo sapiens (Human))
BDBM17054
PNG
((2S,3R,4R,6R,18R)-18-hydroxy-3-methoxy-2-methyl-4-...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4[C@@H](O)NC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O4/c1-28-25(35-3)15(29-2)12-18(36-28)31-16-10-6-4-8-13(16)19-21-22(27(34)30-26(21)33)20-14-9-5-7-11-17(14)32(28)24(20)23(19)31/h4-11,15,18,25,27,29,34H,12H2,1-3H3,(H,30,33)/t15-,18-,25-,27-,28+/m1/s1
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n/an/a 6n/an/an/an/a7.530



University of Dundee



Assay Description
In vitro PDK1 assay using purified enzyme, was incubated with substrate PDKtide, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P inco...


Structure 12: 215-26 (2004)


Article DOI: 10.1016/j.str.2004.01.005
BindingDB Entry DOI: 10.7270/Q2SJ1HV2
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
3-phosphoinositide-dependent protein kinase 1 (aa 51-359)


(Homo sapiens (Human))
BDBM282371
PNG
(5-cyano-N-((S)-1-(4- fluorophenyl)ethyl)-2- ((R)-2...)
Show SMILES CNc1ncc2cc(O[C@H](C)CNc3ncc(cc3C(=O)N[C@@H](C)c3ccc(F)cc3)C#N)ccc2n1
Show InChI InChI=1S/C27H26FN7O2/c1-16(37-22-8-9-24-20(11-22)15-33-27(30-3)35-24)13-31-25-23(10-18(12-29)14-32-25)26(36)34-17(2)19-4-6-21(28)7-5-19/h4-11,14-17H,13H2,1-3H3,(H,31,32)(H,34,36)(H,30,33,35)/t16-,17+/m1/s1
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n/an/a>5.00E+3n/an/an/an/an/an/a



Sunesis Pharmaceuticals Inc

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)


BindingDB Entry DOI: 10.7270/Q2S46V16
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (aa 51-359)


(Homo sapiens (Human))
BDBM282372
PNG
(6-cyano-N-((S)-1-(3,4- difluorophenyl)ethyl)-3- ((...)
Show SMILES CNc1ncc2cc(O[C@H](C)CNc3ncc(nc3C(=O)N[C@@H](C)c3ccc(F)c(F)c3)C#N)ccc2n1
Show InChI InChI=1S/C26H24F2N8O2/c1-14(38-19-5-7-22-17(8-19)12-33-26(30-3)36-22)11-31-24-23(35-18(10-29)13-32-24)25(37)34-15(2)16-4-6-20(27)21(28)9-16/h4-9,12-15H,11H2,1-3H3,(H,31,32)(H,34,37)(H,30,33,36)/t14-,15+/m1/s1
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n/an/a 550n/an/an/an/an/an/a



Sunesis Pharmaceuticals Inc

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)


BindingDB Entry DOI: 10.7270/Q2S46V16
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (aa 51-359)


(Homo sapiens (Human))
BDBM282373
PNG
(5-cyano-N-((S)-1-(4- fluorophenyl)ethyl)-2- ((S)-2...)
Show SMILES CNc1ncc2cc(O[C@@H](C)CNc3ncc(cc3C(=O)N[C@@H](C)c3ccc(F)cc3)C#N)ccc2n1
Show InChI InChI=1S/C27H26FN7O2/c1-16(37-22-8-9-24-20(11-22)15-33-27(30-3)35-24)13-31-25-23(10-18(12-29)14-32-25)26(36)34-17(2)19-4-6-21(28)7-5-19/h4-11,14-17H,13H2,1-3H3,(H,31,32)(H,34,36)(H,30,33,35)/t16-,17-/m0/s1
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n/an/a 3.00E+3n/an/an/an/an/an/a



Sunesis Pharmaceuticals Inc

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)


BindingDB Entry DOI: 10.7270/Q2S46V16
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (aa 51-359)


(Homo sapiens (Human))
BDBM282374
PNG
(6-cyano-N-((S)-1-(3,4- difluorophenyl)ethyl)-3- ((...)
Show SMILES CNc1ncc2cc(O[C@@H](C)CNc3ncc(nc3C(=O)N[C@@H](C)c3ccc(F)c(F)c3)C#N)ccc2n1
Show InChI InChI=1S/C26H24F2N8O2/c1-14(38-19-5-7-22-17(8-19)12-33-26(30-3)36-22)11-31-24-23(35-18(10-29)13-32-24)25(37)34-15(2)16-4-6-20(27)21(28)9-16/h4-9,12-15H,11H2,1-3H3,(H,31,32)(H,34,37)(H,30,33,36)/t14-,15-/m0/s1
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n/an/a 550n/an/an/an/an/an/a



Sunesis Pharmaceuticals Inc

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)


BindingDB Entry DOI: 10.7270/Q2S46V16
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (aa 51-359)


(Homo sapiens (Human))
BDBM282375
PNG
((S)-5-cyano-N-(1-(4- fluorophenyl)ethyl)-2- (3-(2-...)
Show SMILES CNc1ncc2cc(ccc2n1)C#CCNc1ncc(cc1C(=O)N[C@@H](C)c1ccc(F)cc1)C#N
Show InChI InChI=1S/C27H22FN7O/c1-17(20-6-8-22(28)9-7-20)34-26(36)23-13-19(14-29)15-32-25(23)31-11-3-4-18-5-10-24-21(12-18)16-33-27(30-2)35-24/h5-10,12-13,15-17H,11H2,1-2H3,(H,31,32)(H,34,36)(H,30,33,35)/t17-/m0/s1
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n/an/a<100n/an/an/an/an/an/a



Sunesis Pharmaceuticals Inc

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)


BindingDB Entry DOI: 10.7270/Q2S46V16
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (aa 51-359)


(Homo sapiens (Human))
BDBM282376
PNG
(N-(3,4-difluorobenzyl)-2- (2-(2-(methylamino)quina...)
Show SMILES CNc1ncc2cc(ccc2n1)C#CCNc1ncc(cc1C(=O)NCc1ccc(F)c(F)c1)C(F)(F)F
Show InChI InChI=1S/C26H19F5N6O/c1-32-25-36-13-17-9-15(5-7-22(17)37-25)3-2-8-33-23-19(11-18(14-34-23)26(29,30)31)24(38)35-12-16-4-6-20(27)21(28)10-16/h4-7,9-11,13-14H,8,12H2,1H3,(H,33,34)(H,35,38)(H,32,36,37)
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n/an/a<100n/an/an/an/an/an/a



Sunesis Pharmaceuticals Inc

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)


BindingDB Entry DOI: 10.7270/Q2S46V16
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (aa 51-359)


(Homo sapiens (Human))
BDBM282377
PNG
((S)-2-(3-(2-aminoquinazolin- 6-yl)prop-2-ynylamino...)
Show SMILES C[C@H](NC(=O)c1cc(cnc1NCC#Cc1ccc2nc(N)ncc2c1)C#N)c1ccc(F)cc1
Show InChI InChI=1S/C26H20FN7O/c1-16(19-5-7-21(27)8-6-19)33-25(35)22-12-18(13-28)14-31-24(22)30-10-2-3-17-4-9-23-20(11-17)15-32-26(29)34-23/h4-9,11-12,14-16H,10H2,1H3,(H,30,31)(H,33,35)(H2,29,32,34)/t16-/m0/s1
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n/an/a<100n/an/an/an/an/an/a



Sunesis Pharmaceuticals Inc

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)


BindingDB Entry DOI: 10.7270/Q2S46V16
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (aa 51-359)


(Homo sapiens (Human))
BDBM282378
PNG
((S)-3-(3-(2-aminoquinazolin- 6-yl)prop-2-ynylamino...)
Show SMILES C[C@H](NC(=O)c1nc(cnc1NCC#Cc1ccc2nc(N)ncc2c1)C#N)c1ccc(F)c(F)c1
Show InChI InChI=1S/C25H18F2N8O/c1-14(16-5-6-19(26)20(27)10-16)33-24(36)22-23(31-13-18(11-28)34-22)30-8-2-3-15-4-7-21-17(9-15)12-32-25(29)35-21/h4-7,9-10,12-14H,8H2,1H3,(H,30,31)(H,33,36)(H2,29,32,35)/t14-/m0/s1
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n/an/a<100n/an/an/an/an/an/a



Sunesis Pharmaceuticals Inc

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)


BindingDB Entry DOI: 10.7270/Q2S46V16
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (aa 51-359)


(Homo sapiens (Human))
BDBM282379
PNG
(1-(4-(5-aminopyrazin-2-yl)benzyl)-3-(3,4-difluorob...)
Show SMILES Nc1cnc(cn1)-c1ccc(Cn2nc(NCc3ccc(F)c(F)c3)c3cc(cnc23)[N+]#[C-])cc1
Show InChI InChI=1S/C25H18F2N8/c1-29-18-9-19-24(32-10-16-4-7-20(26)21(27)8-16)34-35(25(19)33-11-18)14-15-2-5-17(6-3-15)22-12-31-23(28)13-30-22/h2-9,11-13H,10,14H2,(H2,28,31)(H,32,34)
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n/an/a 550n/an/an/an/an/an/a



Sunesis Pharmaceuticals Inc

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)


BindingDB Entry DOI: 10.7270/Q2S46V16
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (aa 51-359)


(Homo sapiens (Human))
BDBM282380
PNG
(2-(4-(3-amino-1H-pyrazolo[3,4-b]pyridin-5-yl)benzy...)
Show SMILES Nc1n[nH]c2ncc(cc12)-c1ccc(CNc2ncc(cc2C(=O)NC2CC2)C(F)(F)F)cc1
Show InChI InChI=1S/C23H20F3N7O/c24-23(25,26)15-8-18(22(34)31-16-5-6-16)20(30-11-15)28-9-12-1-3-13(4-2-12)14-7-17-19(27)32-33-21(17)29-10-14/h1-4,7-8,10-11,16H,5-6,9H2,(H,28,30)(H,31,34)(H3,27,29,32,33)
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n/an/a 550n/an/an/an/an/an/a



Sunesis Pharmaceuticals Inc

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)


BindingDB Entry DOI: 10.7270/Q2S46V16
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (aa 51-359)


(Homo sapiens (Human))
BDBM282381
PNG
(2-(4-(3-amino-1H-pyrazolo [3,4-b]pyridin-5-yl) ben...)
Show SMILES COc1cc(F)ccc1NC(=O)c1cc(cnc1NCc1ccc(cc1)-c1cnc2[nH]nc(N)c2c1)C(F)(F)F
Show InChI InChI=1S/C27H21F4N7O2/c1-40-22-10-18(28)6-7-21(22)36-26(39)20-9-17(27(29,30)31)13-35-24(20)33-11-14-2-4-15(5-3-14)16-8-19-23(32)37-38-25(19)34-12-16/h2-10,12-13H,11H2,1H3,(H,33,35)(H,36,39)(H3,32,34,37,38)
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)


BindingDB Entry DOI: 10.7270/Q2S46V16
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (aa 51-359)


(Homo sapiens (Human))
BDBM282382
PNG
(2-(4-(3-amino-1H-pyrazolo [3,4-b]pyridin-5-yl) ben...)
Show SMILES Nc1n[nH]c2ncc(cc12)-c1ccc(CNc2ncc(cc2C(=O)Nc2cccc(F)c2)C(F)(F)F)cc1
Show InChI InChI=1S/C26H19F4N7O/c27-18-2-1-3-19(10-18)35-25(38)21-9-17(26(28,29)30)13-34-23(21)32-11-14-4-6-15(7-5-14)16-8-20-22(31)36-37-24(20)33-12-16/h1-10,12-13H,11H2,(H,32,34)(H,35,38)(H3,31,33,36,37)
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)


BindingDB Entry DOI: 10.7270/Q2S46V16
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (aa 51-359)


(Homo sapiens (Human))
BDBM282383
PNG
(2-(4-(3-amino-1H-pyrazolo [3,4-b]pyridin-5-yl) ben...)
Show SMILES Nc1n[nH]c2ncc(cc12)-c1ccc(CNc2ncc(cc2C(=O)Nc2ccc(F)c(F)c2)C(F)(F)F)cc1
Show InChI InChI=1S/C26H18F5N7O/c27-20-6-5-17(9-21(20)28)36-25(39)19-8-16(26(29,30)31)12-35-23(19)33-10-13-1-3-14(4-2-13)15-7-18-22(32)37-38-24(18)34-11-15/h1-9,11-12H,10H2,(H,33,35)(H,36,39)(H3,32,34,37,38)
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)


BindingDB Entry DOI: 10.7270/Q2S46V16
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (aa 51-359)


(Homo sapiens (Human))
BDBM282384
PNG
(2-(4-(3-amino-1H-pyrazolo [3,4-b]pyridin-5-yl) ben...)
Show SMILES Nc1n[nH]c2ncc(cc12)-c1ccc(CNc2ncc(cc2C(=O)NCC2CCCC2)C(F)(F)F)cc1
Show InChI InChI=1S/C26H26F3N7O/c27-26(28,29)19-10-21(25(37)34-12-15-3-1-2-4-15)23(33-14-19)31-11-16-5-7-17(8-6-16)18-9-20-22(30)35-36-24(20)32-13-18/h5-10,13-15H,1-4,11-12H2,(H,31,33)(H,34,37)(H3,30,32,35,36)
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)


BindingDB Entry DOI: 10.7270/Q2S46V16
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (aa 51-359)


(Homo sapiens (Human))
BDBM282385
PNG
(2-(4-(3-amino-1H-pyrazolo [3,4-b]pyridin-5-yl) ben...)
Show SMILES Nc1n[nH]c2ncc(cc12)-c1ccc(CNc2ncc(cc2C(=O)NCC2CCCO2)C(F)(F)F)cc1
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)


BindingDB Entry DOI: 10.7270/Q2S46V16
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (aa 51-359)


(Homo sapiens (Human))
BDBM282386
PNG
((S)-2-(4-(3-amino-1H-pyrazolo [3,4-b]pyridin-5-yl)...)
Show SMILES Nc1n[nH]c2ncc(cc12)-c1ccc(CNc2ncc(cc2C(=O)N[C@H](CO)c2ccc(F)cc2)C(F)(F)F)cc1
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)


BindingDB Entry DOI: 10.7270/Q2S46V16
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (aa 51-359)


(Homo sapiens (Human))
BDBM282387
PNG
(2-(4-(3-amino-1H-pyrazolo [3,4-b]pyridin-5-yl) ben...)
Show SMILES Nc1n[nH]c2ncc(cc12)-c1ccc(CNc2ncc(cc2C(=O)Nc2ccc(F)nc2)C(F)(F)F)cc1
Show InChI InChI=1S/C25H18F4N8O/c26-20-6-5-17(12-31-20)35-24(38)19-8-16(25(27,28)29)11-34-22(19)32-9-13-1-3-14(4-2-13)15-7-18-21(30)36-37-23(18)33-10-15/h1-8,10-12H,9H2,(H,32,34)(H,35,38)(H3,30,33,36,37)
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)


BindingDB Entry DOI: 10.7270/Q2S46V16
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (aa 51-359)


(Homo sapiens (Human))
BDBM282388
PNG
(2-(4-(3-amino-1H-pyrazolo [3,4-b]pyridin-5-yl) ben...)
Show SMILES Nc1n[nH]c2ncc(cc12)-c1ccc(CNc2ncc(cc2C(=O)NCC2CCOC2)C(F)(F)F)cc1
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)


BindingDB Entry DOI: 10.7270/Q2S46V16
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (aa 51-359)


(Homo sapiens (Human))
BDBM282389
PNG
(2-(4-(3-amino-1H-pyrazolo [3,4-b]pyridin-5-yl) ben...)
Show SMILES Nc1n[nH]c2ncc(cc12)-c1ccc(CNc2ncc(cc2C(=O)NCCC2CC2)C(F)(F)F)cc1
Show InChI InChI=1S/C25H24F3N7O/c26-25(27,28)18-10-20(24(36)30-8-7-14-1-2-14)22(33-13-18)31-11-15-3-5-16(6-4-15)17-9-19-21(29)34-35-23(19)32-12-17/h3-6,9-10,12-14H,1-2,7-8,11H2,(H,30,36)(H,31,33)(H3,29,32,34,35)
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)


BindingDB Entry DOI: 10.7270/Q2S46V16
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (aa 51-359)


(Homo sapiens (Human))
BDBM282390
PNG
(2-(4-(3-amino-1H-pyrazolo [3,4-b]pyridin-5-yl) ben...)
Show SMILES Cn1cnc(CNC(=O)c2cc(cnc2NCc2ccc(cc2)-c2cnc3[nH]nc(N)c3c2)C(F)(F)F)c1
Show InChI InChI=1S/C25H22F3N9O/c1-37-12-18(34-13-37)11-33-24(38)20-7-17(25(26,27)28)10-32-22(20)30-8-14-2-4-15(5-3-14)16-6-19-21(29)35-36-23(19)31-9-16/h2-7,9-10,12-13H,8,11H2,1H3,(H,30,32)(H,33,38)(H3,29,31,35,36)
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)


BindingDB Entry DOI: 10.7270/Q2S46V16
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (aa 51-359)


(Homo sapiens (Human))
BDBM282391
PNG
(2-(4-(3-amino-1H-pyrazolo [3,4-b]pyridin-5-yl) ben...)
Show SMILES Nc1n[nH]c2ncc(cc12)-c1ccc(CNc2ncc(cc2C(=O)NCC#C)C(F)(F)F)cc1
Show InChI InChI=1S/C23H18F3N7O/c1-2-7-28-22(34)18-9-16(23(24,25)26)12-31-20(18)29-10-13-3-5-14(6-4-13)15-8-17-19(27)32-33-21(17)30-11-15/h1,3-6,8-9,11-12H,7,10H2,(H,28,34)(H,29,31)(H3,27,30,32,33)
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)


BindingDB Entry DOI: 10.7270/Q2S46V16
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (aa 51-359)


(Homo sapiens (Human))
BDBM282392
PNG
(2-(4-(3-amino-1H-pyrazolo [3,4-b]pyridin-5-yl) ben...)
Show SMILES Nc1n[nH]c2ncc(cc12)-c1ccc(CNc2ncc(cc2C(=O)NCC2CC2)C(F)(F)F)cc1
Show InChI InChI=1S/C24H22F3N7O/c25-24(26,27)17-8-19(23(35)32-10-13-1-2-13)21(31-12-17)29-9-14-3-5-15(6-4-14)16-7-18-20(28)33-34-22(18)30-11-16/h3-8,11-13H,1-2,9-10H2,(H,29,31)(H,32,35)(H3,28,30,33,34)
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)


BindingDB Entry DOI: 10.7270/Q2S46V16
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (aa 51-359)


(Homo sapiens (Human))
BDBM282393
PNG
(2-(4-(3-amino-1H-pyrazolo [3,4-b]pyridin-5-yl) ben...)
Show SMILES Nc1n[nH]c2ncc(cc12)-c1ccc(CNc2ncc(cc2C(=O)NCc2cscn2)C(F)(F)F)cc1
Show InChI InChI=1S/C24H19F3N8OS/c25-24(26,27)16-6-19(23(36)32-10-17-11-37-12-33-17)21(31-9-16)29-7-13-1-3-14(4-2-13)15-5-18-20(28)34-35-22(18)30-8-15/h1-6,8-9,11-12H,7,10H2,(H,29,31)(H,32,36)(H3,28,30,34,35)
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)


BindingDB Entry DOI: 10.7270/Q2S46V16
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (aa 51-359)


(Homo sapiens (Human))
BDBM282394
PNG
(US10030016, Example 274)
Show SMILES Nc1n[nH]c2ncc(cc12)-c1ccc(CNc2ncc(cc2C(=O)Nc2ccccn2)C(F)(F)F)cc1
Show InChI InChI=1S/C25H19F3N8O/c26-25(27,28)17-10-19(24(37)34-20-3-1-2-8-30-20)22(33-13-17)31-11-14-4-6-15(7-5-14)16-9-18-21(29)35-36-23(18)32-12-16/h1-10,12-13H,11H2,(H,31,33)(H,30,34,37)(H3,29,32,35,36)
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)


BindingDB Entry DOI: 10.7270/Q2S46V16
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (aa 51-359)


(Homo sapiens (Human))
BDBM282395
PNG
((R)-2-(4-(3-amino-1H- pyrazolo[3,4-b]pyridin- 5-yl...)
Show SMILES C[C@@H](NC(=O)c1cc(cnc1NCc1ccc(cc1)-c1cnc2[nH]nc(N)c2c1)C(F)(F)F)c1ccc(Br)cc1
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)


BindingDB Entry DOI: 10.7270/Q2S46V16
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (aa 51-359)


(Homo sapiens (Human))
BDBM282396
PNG
(2-(4-(3-amino-1H-pyrazolo [3,4-b]pyridin-5-yl) ben...)
Show SMILES Nc1n[nH]c2ncc(cc12)-c1ccc(CNc2ncc(cc2C(=O)Nc2ccc(nc2)C(F)(F)F)C(F)(F)F)cc1
Show InChI InChI=1S/C26H18F6N8O/c27-25(28,29)16-8-19(24(41)38-17-5-6-20(34-12-17)26(30,31)32)22(37-11-16)35-9-13-1-3-14(4-2-13)15-7-18-21(33)39-40-23(18)36-10-15/h1-8,10-12H,9H2,(H,35,37)(H,38,41)(H3,33,36,39,40)
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)


BindingDB Entry DOI: 10.7270/Q2S46V16
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (aa 51-359)


(Homo sapiens (Human))
BDBM282397
PNG
(2-(4-(3-amino-1H-pyrazolo [3,4-b]pyridin-5-yl) ben...)
Show SMILES C[C@H](NC(=O)c1cc(cnc1NCc1ccc(cc1)-c1cnc2[nH]nc(N)c2c1)C(F)(F)F)c1ccc(Cl)cc1
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)


BindingDB Entry DOI: 10.7270/Q2S46V16
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (aa 51-359)


(Homo sapiens (Human))
BDBM282398
PNG
(2-(4-(3-amino-1H-pyrazolo [3,4-b]pyridin-5-yl) ben...)
Show SMILES Nc1n[nH]c2ncc(cc12)-c1ccc(CNc2ncc(cc2C(=O)Nc2c(F)cc(F)cc2F)C(F)(F)F)cc1
Show InChI InChI=1S/C26H17F6N7O/c27-16-7-19(28)21(20(29)8-16)37-25(40)18-6-15(26(30,31)32)11-36-23(18)34-9-12-1-3-13(4-2-12)14-5-17-22(33)38-39-24(17)35-10-14/h1-8,10-11H,9H2,(H,34,36)(H,37,40)(H3,33,35,38,39)
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)


BindingDB Entry DOI: 10.7270/Q2S46V16
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (aa 51-359)


(Homo sapiens (Human))
BDBM282399
PNG
(2-(4-(3-amino-1H-pyrazolo [3,4-b]pyridin-5-yl) ben...)
Show SMILES Nc1n[nH]c2ncc(cc12)-c1ccc(CNc2ncc(cc2C(=O)NCc2ccc(Cl)cc2)C(F)(F)F)cc1
Show InChI InChI=1S/C27H21ClF3N7O/c28-20-7-3-16(4-8-20)12-36-26(39)22-10-19(27(29,30)31)14-35-24(22)33-11-15-1-5-17(6-2-15)18-9-21-23(32)37-38-25(21)34-13-18/h1-10,13-14H,11-12H2,(H,33,35)(H,36,39)(H3,32,34,37,38)
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)


BindingDB Entry DOI: 10.7270/Q2S46V16
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (aa 51-359)


(Homo sapiens (Human))
BDBM282400
PNG
(2-(4-(3-amino-1H-pyrazolo [3,4-b]pyridin-5-yl) ben...)
Show SMILES CC(C)c1ccc(NC(=O)c2cc(cnc2NCc2ccc(cc2)-c2cnc3[nH]nc(N)c3c2)C(F)(F)F)cc1
Show InChI InChI=1S/C29H26F3N7O/c1-16(2)18-7-9-22(10-8-18)37-28(40)24-12-21(29(30,31)32)15-36-26(24)34-13-17-3-5-19(6-4-17)20-11-23-25(33)38-39-27(23)35-14-20/h3-12,14-16H,13H2,1-2H3,(H,34,36)(H,37,40)(H3,33,35,38,39)
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n/an/a 550n/an/an/an/an/an/a



Sunesis Pharmaceuticals Inc

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)


BindingDB Entry DOI: 10.7270/Q2S46V16
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (aa 51-359)


(Homo sapiens (Human))
BDBM282401
PNG
(2-(4-(3-amino-1H-pyrazolo [3,4-b]pyridin-5-yl) ben...)
Show SMILES Nc1n[nH]c2ncc(cc12)-c1ccc(CNc2ncc(cc2C(=O)NCc2cccc(Cl)c2)C(F)(F)F)cc1
Show InChI InChI=1S/C27H21ClF3N7O/c28-20-3-1-2-16(8-20)12-36-26(39)22-10-19(27(29,30)31)14-35-24(22)33-11-15-4-6-17(7-5-15)18-9-21-23(32)37-38-25(21)34-13-18/h1-10,13-14H,11-12H2,(H,33,35)(H,36,39)(H3,32,34,37,38)
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)


BindingDB Entry DOI: 10.7270/Q2S46V16
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (aa 51-359)


(Homo sapiens (Human))
BDBM282402
PNG
((S)-2-(4-(3-amino-1H-pyrazolo [3,4-b]pyridin-5-yl)...)
Show SMILES C[C@H](NC(=O)c1cc(cnc1NCc1ccc(cc1)-c1cnc2[nH]nc(N)c2c1)C(F)(F)F)c1ccc(Br)cc1
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)


BindingDB Entry DOI: 10.7270/Q2S46V16
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (aa 51-359)


(Homo sapiens (Human))
BDBM282403
PNG
((R)-2-(4-(3-amino-1H-pyrazolo [3,4-b]pyridin-5-yl)...)
Show SMILES Nc1n[nH]c2ncc(cc12)-c1ccc(CNc2ncc(cc2C(=O)N[C@@H](CO)c2ccc(Br)cc2)C(F)(F)F)cc1
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)


BindingDB Entry DOI: 10.7270/Q2S46V16
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (aa 51-359)


(Homo sapiens (Human))
BDBM282404
PNG
(2-(4-(3-amino-1H-pyrazolo [3,4-b]pyridin-5-yl) ben...)
Show SMILES Nc1n[nH]c2ncc(cc12)-c1ccc(CNc2ncc(cc2C(=O)NC2CCC(F)(F)CC2)C(F)(F)F)cc1
Show InChI InChI=1S/C26H24F5N7O/c27-25(28)7-5-18(6-8-25)36-24(39)20-10-17(26(29,30)31)13-35-22(20)33-11-14-1-3-15(4-2-14)16-9-19-21(32)37-38-23(19)34-12-16/h1-4,9-10,12-13,18H,5-8,11H2,(H,33,35)(H,36,39)(H3,32,34,37,38)
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)


BindingDB Entry DOI: 10.7270/Q2S46V16
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (aa 51-359)


(Homo sapiens (Human))
BDBM282405
PNG
(2-(4-(3-amino-1H-pyrazolo [3,4-b]pyridin-5-yl) ben...)
Show SMILES CN1CCN(Cc2ccc(NC(=O)c3cc(cnc3NCc3ccc(cc3)-c3cnc4[nH]nc(N)c4c3)C(F)(F)F)cc2)CC1
Show InChI InChI=1S/C32H32F3N9O/c1-43-10-12-44(13-11-43)19-21-4-8-25(9-5-21)40-31(45)27-15-24(32(33,34)35)18-39-29(27)37-16-20-2-6-22(7-3-20)23-14-26-28(36)41-42-30(26)38-17-23/h2-9,14-15,17-18H,10-13,16,19H2,1H3,(H,37,39)(H,40,45)(H3,36,38,41,42)
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)


BindingDB Entry DOI: 10.7270/Q2S46V16
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (aa 51-359)


(Homo sapiens (Human))
BDBM282406
PNG
(2-(4-(3-amino-1H-pyrazolo [3,4-b]pyridin-5-yl) ben...)
Show SMILES Nc1n[nH]c2ncc(cc12)-c1ccc(CNc2ncc(cc2C(=O)NCc2ccc(F)c(Cl)c2)C(F)(F)F)cc1
Show InChI InChI=1S/C27H20ClF4N7O/c28-21-7-15(3-6-22(21)29)11-37-26(40)20-9-18(27(30,31)32)13-36-24(20)34-10-14-1-4-16(5-2-14)17-8-19-23(33)38-39-25(19)35-12-17/h1-9,12-13H,10-11H2,(H,34,36)(H,37,40)(H3,33,35,38,39)
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)


BindingDB Entry DOI: 10.7270/Q2S46V16
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (aa 51-359)


(Homo sapiens (Human))
BDBM282407
PNG
(2-(4-(3-amino-1H-pyrazolo [3,4-b]pyridin-5-yl) ben...)
Show SMILES Nc1n[nH]c2ncc(cc12)-c1ccc(CNc2ncc(cc2C(=O)Nc2cncs2)C(F)(F)F)cc1
Show InChI InChI=1S/C23H17F3N8OS/c24-23(25,26)15-6-17(22(35)32-18-10-28-11-36-18)20(31-9-15)29-7-12-1-3-13(4-2-12)14-5-16-19(27)33-34-21(16)30-8-14/h1-6,8-11H,7H2,(H,29,31)(H,32,35)(H3,27,30,33,34)
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n/an/a 550n/an/an/an/an/an/a



Sunesis Pharmaceuticals Inc

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)


BindingDB Entry DOI: 10.7270/Q2S46V16
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (aa 51-359)


(Homo sapiens (Human))
BDBM282408
PNG
(2-(4-(3-amino-1H-pyrazolo [3,4-b]pyridin-5-yl) ben...)
Show SMILES Nc1n[nH]c2ncc(cc12)-c1ccc(CNc2ncc(cc2C(=O)Nc2ccncc2)C(F)(F)F)cc1
Show InChI InChI=1S/C25H19F3N8O/c26-25(27,28)17-10-20(24(37)34-18-5-7-30-8-6-18)22(33-13-17)31-11-14-1-3-15(4-2-14)16-9-19-21(29)35-36-23(19)32-12-16/h1-10,12-13H,11H2,(H,31,33)(H,30,34,37)(H3,29,32,35,36)
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)


BindingDB Entry DOI: 10.7270/Q2S46V16
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (aa 51-359)


(Homo sapiens (Human))
BDBM282409
PNG
(2-(4-(3-amino-1H-pyrazolo [3,4-b]pyridin-5-yl) ben...)
Show SMILES Nc1n[nH]c2ncc(cc12)-c1ccc(CNc2ncc(cc2C(=O)Nc2cccnc2)C(F)(F)F)cc1
Show InChI InChI=1S/C25H19F3N8O/c26-25(27,28)17-9-20(24(37)34-18-2-1-7-30-13-18)22(33-12-17)31-10-14-3-5-15(6-4-14)16-8-19-21(29)35-36-23(19)32-11-16/h1-9,11-13H,10H2,(H,31,33)(H,34,37)(H3,29,32,35,36)
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)


BindingDB Entry DOI: 10.7270/Q2S46V16
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (aa 51-359)


(Homo sapiens (Human))
BDBM282410
PNG
(2-(4-(3-amino-1H-pyrazolo [3,4-b]pyridin-5-yl) ben...)
Show SMILES CN(C(=O)c1cc(cnc1NCc1ccc(cc1)-c1cnc2[nH]nc(N)c2c1)C(F)(F)F)c1ccc(F)cc1
Show InChI InChI=1S/C27H21F4N7O/c1-38(20-8-6-19(28)7-9-20)26(39)22-11-18(27(29,30)31)14-35-24(22)33-12-15-2-4-16(5-3-15)17-10-21-23(32)36-37-25(21)34-13-17/h2-11,13-14H,12H2,1H3,(H,33,35)(H3,32,34,36,37)
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)


BindingDB Entry DOI: 10.7270/Q2S46V16
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (aa 51-359)


(Homo sapiens (Human))
BDBM282411
PNG
(2-(4-(3-amino-1H-pyrazolo [3,4-b]pyridin-5-yl) ben...)
Show SMILES Nc1n[nH]c2ncc(cc12)-c1ccc(CNc2ncc(cc2C(=O)Nc2ccc(F)cc2F)C(F)(F)F)cc1
Show InChI InChI=1S/C26H18F5N7O/c27-17-5-6-21(20(28)9-17)36-25(39)19-8-16(26(29,30)31)12-35-23(19)33-10-13-1-3-14(4-2-13)15-7-18-22(32)37-38-24(18)34-11-15/h1-9,11-12H,10H2,(H,33,35)(H,36,39)(H3,32,34,37,38)
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)


BindingDB Entry DOI: 10.7270/Q2S46V16
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (aa 51-359)


(Homo sapiens (Human))
BDBM282412
PNG
(2-(4-(3-amino-1H-pyrazolo [3,4-b]pyridin-5-yl) ben...)
Show SMILES Nc1n[nH]c2ncc(cc12)-c1ccc(CNc2ncc(cc2C(=O)Nc2ccccc2)C(F)(F)F)cc1
Show InChI InChI=1S/C26H20F3N7O/c27-26(28,29)18-11-21(25(37)34-19-4-2-1-3-5-19)23(33-14-18)31-12-15-6-8-16(9-7-15)17-10-20-22(30)35-36-24(20)32-13-17/h1-11,13-14H,12H2,(H,31,33)(H,34,37)(H3,30,32,35,36)
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)


BindingDB Entry DOI: 10.7270/Q2S46V16
More data for this
Ligand-Target Pair
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