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Compile Data Set for Download or QSAR

Found 10674 hits Enz. Inhib. hit(s) with Target = '5-hydroxytryptamine receptor 1A'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM29563
PNG
(1-(m-trifluorophenyl)piperazine, 10)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(CC1)C1CCC(CC1)N1C(=O)C2=C(CCCC2)C1=O
Show InChI InChI=1S/C25H30F3N3O2/c26-25(27,28)17-4-3-5-20(16-17)30-14-12-29(13-15-30)18-8-10-19(11-9-18)31-23(32)21-6-1-2-7-22(21)24(31)33/h3-5,16,18-19H,1-2,6-15H2
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0.300 -56.5n/an/an/an/an/a7.437



Polish Academy of Science



Assay Description
Competition experiments were performed in the presence radioligand with membrane protein and test compounds. After incubation, the reaction stopped b...


Bioorg Med Chem 15: 7116-25 (2007)


Article DOI: 10.1016/j.bmc.2007.07.029
BindingDB Entry DOI: 10.7270/Q2G15Z6G
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM248048
PNG
(5-(1-(3-cyclopentenylbenzyl)piperidin-4-yl)-1H-ben...)
Show SMILES O=c1[nH]c2ccc(cc2[nH]1)C1CCN(Cc2cccc(c2)C2=CCCC2)CC1
Show InChI InChI=1S/C24H27N3O/c28-24-25-22-9-8-21(15-23(22)26-24)19-10-12-27(13-11-19)16-17-4-3-7-20(14-17)18-5-1-2-6-18/h3-5,7-9,14-15,19H,1-2,6,10-13,16H2,(H2,25,26,28)
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1.20 -53.0n/an/an/an/an/a7.437



King Fahd University of Petroleum & Minerals



Assay Description
Human-cloned 5-HT1A serotonin receptors stably expressed in HEK293-EBNA cells (Perkin-Elmer, Waltham, MA) were radiolabeled with 1.0nM [3H]-8-OH-DPAT...


J Enzyme Inhib Med Chem 29: 281-91 (2014)


Article DOI: 10.3109/14756366.2013.776556
BindingDB Entry DOI: 10.7270/Q2SN07WV
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM29567
PNG
(1-(m-trifluorophenyl)piperazine, 14)
Show SMILES CC1=C(C)C(=O)N(C2CCC(CC2)N2CCN(CC2)c2cccc(c2)C(F)(F)F)C1=O
Show InChI InChI=1S/C23H28F3N3O2/c1-15-16(2)22(31)29(21(15)30)19-8-6-18(7-9-19)27-10-12-28(13-11-27)20-5-3-4-17(14-20)23(24,25)26/h3-5,14,18-19H,6-13H2,1-2H3
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1.30 -52.8n/an/an/an/an/a7.437



Polish Academy of Science



Assay Description
Competition experiments were performed in the presence radioligand with membrane protein and test compounds. After incubation, the reaction stopped b...


Bioorg Med Chem 15: 7116-25 (2007)


Article DOI: 10.1016/j.bmc.2007.07.029
BindingDB Entry DOI: 10.7270/Q2G15Z6G
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM29565
PNG
(1-(m-trifluorophenyl)piperazine, 12)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(CC1)C1CCC(CC1)N1C(=O)C2CC=CCC2C1=O
Show InChI InChI=1S/C25H30F3N3O2/c26-25(27,28)17-4-3-5-20(16-17)30-14-12-29(13-15-30)18-8-10-19(11-9-18)31-23(32)21-6-1-2-7-22(21)24(31)33/h1-5,16,18-19,21-22H,6-15H2
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1.5 -52.4n/an/an/an/an/a7.437



Polish Academy of Science



Assay Description
Competition experiments were performed in the presence radioligand with membrane protein and test compounds. After incubation, the reaction stopped b...


Bioorg Med Chem 15: 7116-25 (2007)


Article DOI: 10.1016/j.bmc.2007.07.029
BindingDB Entry DOI: 10.7270/Q2G15Z6G
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM248055
PNG
(5-(4-((5-cyclopentenylpyridin-3-yl)methyl)piperazi...)
Show SMILES O=c1[nH]c2ccc(cc2[nH]1)N1CCN(Cc2cncc(c2)C2=CCCC2)CC1
Show InChI InChI=1S/C22H25N5O/c28-22-24-20-6-5-19(12-21(20)25-22)27-9-7-26(8-10-27)15-16-11-18(14-23-13-16)17-3-1-2-4-17/h3,5-6,11-14H,1-2,4,7-10,15H2,(H2,24,25,28)
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1.70 -52.1n/an/an/an/an/a7.437



King Fahd University of Petroleum & Minerals



Assay Description
Human-cloned 5-HT1A serotonin receptors stably expressed in HEK293-EBNA cells (Perkin-Elmer, Waltham, MA) were radiolabeled with 1.0nM [3H]-8-OH-DPAT...


J Enzyme Inhib Med Chem 29: 281-91 (2014)


Article DOI: 10.3109/14756366.2013.776556
BindingDB Entry DOI: 10.7270/Q2SN07WV
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM29566
PNG
(1-(m-trifluorophenyl)piperazine, 13)
Show SMILES CC1=C(C)C(=O)N(CCCCN2CCN(CC2)c2cccc(c2)C(F)(F)F)C1=O
Show InChI InChI=1S/C21H26F3N3O2/c1-15-16(2)20(29)27(19(15)28)9-4-3-8-25-10-12-26(13-11-25)18-7-5-6-17(14-18)21(22,23)24/h5-7,14H,3-4,8-13H2,1-2H3
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2.20 -51.4n/an/an/an/an/a7.437



Polish Academy of Science



Assay Description
Competition experiments were performed in the presence radioligand with membrane protein and test compounds. After incubation, the reaction stopped b...


Bioorg Med Chem 15: 7116-25 (2007)


Article DOI: 10.1016/j.bmc.2007.07.029
BindingDB Entry DOI: 10.7270/Q2G15Z6G
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM29561
PNG
(1-(m-trifluorophenyl)piperazine, 8)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(CC1)C1CCC(CC1)N1C(=O)CCCC1=O
Show InChI InChI=1S/C22H28F3N3O2/c23-22(24,25)16-3-1-4-19(15-16)27-13-11-26(12-14-27)17-7-9-18(10-8-17)28-20(29)5-2-6-21(28)30/h1,3-4,15,17-18H,2,5-14H2
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2.60 -51.0n/an/an/an/an/a7.437



Polish Academy of Science



Assay Description
Competition experiments were performed in the presence radioligand with membrane protein and test compounds. After incubation, the reaction stopped b...


Bioorg Med Chem 15: 7116-25 (2007)


Article DOI: 10.1016/j.bmc.2007.07.029
BindingDB Entry DOI: 10.7270/Q2G15Z6G
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM29560
PNG
(1-(m-trifluorophenyl)piperazine, 7)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(CCCCN2C(=O)CCCC2=O)CC1
Show InChI InChI=1S/C20H26F3N3O2/c21-20(22,23)16-5-3-6-17(15-16)25-13-11-24(12-14-25)9-1-2-10-26-18(27)7-4-8-19(26)28/h3,5-6,15H,1-2,4,7-14H2
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3 -50.6n/an/an/an/an/a7.437



Polish Academy of Science



Assay Description
Competition experiments were performed in the presence radioligand with membrane protein and test compounds. After incubation, the reaction stopped b...


Bioorg Med Chem 15: 7116-25 (2007)


Article DOI: 10.1016/j.bmc.2007.07.029
BindingDB Entry DOI: 10.7270/Q2G15Z6G
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM248054
PNG
(5-(4-(3-cyclopentenylbenzyl)piperazin-1-yl)-1H-ben...)
Show SMILES O=c1[nH]c2ccc(cc2[nH]1)N1CCN(Cc2cccc(c2)C2=CCCC2)CC1
Show InChI InChI=1S/C23H26N4O/c28-23-24-21-9-8-20(15-22(21)25-23)27-12-10-26(11-13-27)16-17-4-3-7-19(14-17)18-5-1-2-6-18/h3-5,7-9,14-15H,1-2,6,10-13,16H2,(H2,24,25,28)
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3.10 -50.5n/an/an/an/an/a7.437



King Fahd University of Petroleum & Minerals



Assay Description
Human-cloned 5-HT1A serotonin receptors stably expressed in HEK293-EBNA cells (Perkin-Elmer, Waltham, MA) were radiolabeled with 1.0nM [3H]-8-OH-DPAT...


J Enzyme Inhib Med Chem 29: 281-91 (2014)


Article DOI: 10.3109/14756366.2013.776556
BindingDB Entry DOI: 10.7270/Q2SN07WV
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM29546
PNG
(benzimidazolone scaffold, 15d)
Show SMILES COc1ccccc1N1CCN(CCCn2c3ccccc3[nH]c2=O)CC1
Show InChI InChI=1S/C21H26N4O2/c1-27-20-10-5-4-9-19(20)24-15-13-23(14-16-24)11-6-12-25-18-8-3-2-7-17(18)22-21(25)26/h2-5,7-10H,6,11-16H2,1H3,(H,22,26)
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3.40 -50.3n/an/an/an/an/a7.437



CNRS



Assay Description
Competition experiments were performed in the presence radioligand with membrane protein and test compounds. After incubation, the reaction stopped b...


Bioorg Med Chem Lett 19: 1600-3 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.008
BindingDB Entry DOI: 10.7270/Q2KS6PW1
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM29557
PNG
(1-(m-trifluorophenyl)piperazine, 4)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(CC1)C1CCC(CC1)N1C(=O)CCC1=O
Show InChI InChI=1S/C21H26F3N3O2/c22-21(23,24)15-2-1-3-18(14-15)26-12-10-25(11-13-26)16-4-6-17(7-5-16)27-19(28)8-9-20(27)29/h1-3,14,16-17H,4-13H2
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4 -49.9n/an/an/an/an/a7.437



Polish Academy of Science



Assay Description
Competition experiments were performed in the presence radioligand with membrane protein and test compounds. After incubation, the reaction stopped b...


Bioorg Med Chem 15: 7116-25 (2007)


Article DOI: 10.1016/j.bmc.2007.07.029
BindingDB Entry DOI: 10.7270/Q2G15Z6G
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM29558
PNG
(1-(m-trifluorophenyl)piperazine, 5)
Show SMILES CC1(C)CC(=O)N(CCCCN2CCN(CC2)c2cccc(c2)C(F)(F)F)C(=O)C1
Show InChI InChI=1S/C22H30F3N3O2/c1-21(2)15-19(29)28(20(30)16-21)9-4-3-8-26-10-12-27(13-11-26)18-7-5-6-17(14-18)22(23,24)25/h5-7,14H,3-4,8-13,15-16H2,1-2H3
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4 -49.9n/an/an/an/an/a7.437



Polish Academy of Science



Assay Description
Competition experiments were performed in the presence radioligand with membrane protein and test compounds. After incubation, the reaction stopped b...


Bioorg Med Chem 15: 7116-25 (2007)


Article DOI: 10.1016/j.bmc.2007.07.029
BindingDB Entry DOI: 10.7270/Q2G15Z6G
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM248052
PNG
(5-(4-((5-phenylpyridin-3-yl)methyl)piperazin-1-yl)...)
Show SMILES O=c1[nH]c2ccc(cc2[nH]1)N1CCN(Cc2cncc(c2)-c2ccccc2)CC1
Show InChI InChI=1S/C23H23N5O/c29-23-25-21-7-6-20(13-22(21)26-23)28-10-8-27(9-11-28)16-17-12-19(15-24-14-17)18-4-2-1-3-5-18/h1-7,12-15H,8-11,16H2,(H2,25,26,29)
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5.30 -49.1n/an/an/an/an/a7.437



King Fahd University of Petroleum & Minerals



Assay Description
Human-cloned 5-HT1A serotonin receptors stably expressed in HEK293-EBNA cells (Perkin-Elmer, Waltham, MA) were radiolabeled with 1.0nM [3H]-8-OH-DPAT...


J Enzyme Inhib Med Chem 29: 281-91 (2014)


Article DOI: 10.3109/14756366.2013.776556
BindingDB Entry DOI: 10.7270/Q2SN07WV
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM29562
PNG
(1-(m-trifluorophenyl)piperazine, 9)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(CCCCN2C(=O)C3=C(CCCC3)C2=O)CC1
Show InChI InChI=1S/C23H28F3N3O2/c24-23(25,26)17-6-5-7-18(16-17)28-14-12-27(13-15-28)10-3-4-11-29-21(30)19-8-1-2-9-20(19)22(29)31/h5-7,16H,1-4,8-15H2
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5.90 -48.9n/an/an/an/an/a7.437



Polish Academy of Science



Assay Description
Competition experiments were performed in the presence radioligand with membrane protein and test compounds. After incubation, the reaction stopped b...


Bioorg Med Chem 15: 7116-25 (2007)


Article DOI: 10.1016/j.bmc.2007.07.029
BindingDB Entry DOI: 10.7270/Q2G15Z6G
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM29548
PNG
(benzimidazolone scaffold, 15f)
Show SMILES COc1ccccc1N1CCN(CCCCn2c3ccccc3[nH]c2=O)CC1
Show InChI InChI=1S/C22H28N4O2/c1-28-21-11-5-4-10-20(21)25-16-14-24(15-17-25)12-6-7-13-26-19-9-3-2-8-18(19)23-22(26)27/h2-5,8-11H,6-7,12-17H2,1H3,(H,23,27)
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6 -48.8n/an/an/an/an/a7.437



CNRS



Assay Description
Competition experiments were performed in the presence radioligand with membrane protein and test compounds. After incubation, the reaction stopped b...


Bioorg Med Chem Lett 19: 1600-3 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.008
BindingDB Entry DOI: 10.7270/Q2KS6PW1
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM248049
PNG
(5-(1-((5-cyclopentenylpyridin-3-yl)methyl)piperidi...)
Show SMILES O=c1[nH]c2ccc(cc2[nH]1)C1CCN(Cc2cncc(c2)C2=CCCC2)CC1
Show InChI InChI=1S/C23H26N4O/c28-23-25-21-6-5-19(12-22(21)26-23)18-7-9-27(10-8-18)15-16-11-20(14-24-13-16)17-3-1-2-4-17/h3,5-6,11-14,18H,1-2,4,7-10,15H2,(H2,25,26,28)
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6.30 -48.7n/an/an/an/an/a7.437



King Fahd University of Petroleum & Minerals



Assay Description
Human-cloned 5-HT1A serotonin receptors stably expressed in HEK293-EBNA cells (Perkin-Elmer, Waltham, MA) were radiolabeled with 1.0nM [3H]-8-OH-DPAT...


J Enzyme Inhib Med Chem 29: 281-91 (2014)


Article DOI: 10.3109/14756366.2013.776556
BindingDB Entry DOI: 10.7270/Q2SN07WV
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM248046
PNG
(5-(1-((5-phenylpyridin-3-yl)methyl)piperidin-4-yl)...)
Show SMILES O=c1[nH]c2ccc(cc2[nH]1)C1CCN(Cc2cncc(c2)-c2ccccc2)CC1
Show InChI InChI=1S/C24H24N4O/c29-24-26-22-7-6-20(13-23(22)27-24)19-8-10-28(11-9-19)16-17-12-21(15-25-14-17)18-4-2-1-3-5-18/h1-7,12-15,19H,8-11,16H2,(H2,26,27,29)
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6.72 -48.5n/an/an/an/an/a7.437



King Fahd University of Petroleum & Minerals



Assay Description
Human-cloned 5-HT1A serotonin receptors stably expressed in HEK293-EBNA cells (Perkin-Elmer, Waltham, MA) were radiolabeled with 1.0nM [3H]-8-OH-DPAT...


J Enzyme Inhib Med Chem 29: 281-91 (2014)


Article DOI: 10.3109/14756366.2013.776556
BindingDB Entry DOI: 10.7270/Q2SN07WV
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM50241119
PNG
(7-(4-Biphenyl-3-ylmethyl-piperazin-1-yl)-3H-benzoo...)
Show SMILES O=c1[nH]c2cccc(N3CCN(Cc4cccc(c4)-c4ccccc4)CC3)c2o1
Show InChI InChI=1S/C24H23N3O2/c28-24-25-21-10-5-11-22(23(21)29-24)27-14-12-26(13-15-27)17-18-6-4-9-20(16-18)19-7-2-1-3-8-19/h1-11,16H,12-15,17H2,(H,25,28)
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7.19 -48.3n/an/an/an/an/a7.437



King Fahd University of Petroleum & Minerals



Assay Description
Human-cloned 5-HT1A serotonin receptors stably expressed in HEK293-EBNA cells (Perkin-Elmer, Waltham, MA) were radiolabeled with 1.0nM [3H]-8-OH-DPAT...


J Enzyme Inhib Med Chem 29: 281-91 (2014)


Article DOI: 10.3109/14756366.2013.776556
BindingDB Entry DOI: 10.7270/Q2SN07WV
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM248056
PNG
(1-(2,3-dihydro-1,4-benzodioxin-5-yl)-4-[[5-(4-fluo...)
Show SMILES Fc1ccc(cc1)-c1cncc(CN2CCN(CC2)c2cccc3OCCOc23)c1
Show InChI InChI=1S/C24H24FN3O2/c25-21-6-4-19(5-7-21)20-14-18(15-26-16-20)17-27-8-10-28(11-9-27)22-2-1-3-23-24(22)30-13-12-29-23/h1-7,14-16H,8-13,17H2
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8.64 -47.9n/an/an/an/an/a7.437



King Fahd University of Petroleum & Minerals



Assay Description
Human-cloned 5-HT1A serotonin receptors stably expressed in HEK293-EBNA cells (Perkin-Elmer, Waltham, MA) were radiolabeled with 1.0nM [3H]-8-OH-DPAT...


J Enzyme Inhib Med Chem 29: 281-91 (2014)


Article DOI: 10.3109/14756366.2013.776556
BindingDB Entry DOI: 10.7270/Q2SN07WV
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM29559
PNG
(1-(m-trifluorophenyl)piperazine, 6)
Show SMILES CC1(C)CC(=O)N(C2CCC(CC2)N2CCN(CC2)c2cccc(c2)C(F)(F)F)C(=O)C1
Show InChI InChI=1S/C24H32F3N3O2/c1-23(2)15-21(31)30(22(32)16-23)19-8-6-18(7-9-19)28-10-12-29(13-11-28)20-5-3-4-17(14-20)24(25,26)27/h3-5,14,18-19H,6-13,15-16H2,1-2H3
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9 -47.8n/an/an/an/an/a7.437



Polish Academy of Science



Assay Description
Competition experiments were performed in the presence radioligand with membrane protein and test compounds. After incubation, the reaction stopped b...


Bioorg Med Chem 15: 7116-25 (2007)


Article DOI: 10.1016/j.bmc.2007.07.029
BindingDB Entry DOI: 10.7270/Q2G15Z6G
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM248047
PNG
(5-(1-((5-(4-Fluorophenyl)pyridin-3-yl)methyl)piper...)
Show SMILES Fc1ccc(cc1)-c1cncc(CN2CCC(CC2)c2ccc3[nH]c(=O)[nH]c3c2)c1
Show InChI InChI=1S/C24H23FN4O/c25-21-4-1-17(2-5-21)20-11-16(13-26-14-20)15-29-9-7-18(8-10-29)19-3-6-22-23(12-19)28-24(30)27-22/h1-6,11-14,18H,7-10,15H2,(H2,27,28,30)
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9.42 -47.7n/an/an/an/an/a7.437



King Fahd University of Petroleum & Minerals



Assay Description
Human-cloned 5-HT1A serotonin receptors stably expressed in HEK293-EBNA cells (Perkin-Elmer, Waltham, MA) were radiolabeled with 1.0nM [3H]-8-OH-DPAT...


J Enzyme Inhib Med Chem 29: 281-91 (2014)


Article DOI: 10.3109/14756366.2013.776556
BindingDB Entry DOI: 10.7270/Q2SN07WV
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM10755
PNG
(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Show SMILES NCCc1c[nH]c2ccc(O)cc12
Show InChI InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2
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10 -47.5n/an/an/an/an/a7.437



King Fahd University of Petroleum & Minerals



Assay Description
Human-cloned 5-HT1A serotonin receptors stably expressed in HEK293-EBNA cells (Perkin-Elmer, Waltham, MA) were radiolabeled with 1.0nM [3H]-8-OH-DPAT...


J Enzyme Inhib Med Chem 29: 281-91 (2014)


Article DOI: 10.3109/14756366.2013.776556
BindingDB Entry DOI: 10.7270/Q2SN07WV
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM248053
PNG
(5-(4-((5-(4-fluorophenyl)pyridin-3-yl)methyl)piper...)
Show SMILES Fc1ccc(cc1)-c1cncc(CN2CCN(CC2)c2ccc3[nH]c(=O)[nH]c3c2)c1
Show InChI InChI=1S/C23H22FN5O/c24-19-3-1-17(2-4-19)18-11-16(13-25-14-18)15-28-7-9-29(10-8-28)20-5-6-21-22(12-20)27-23(30)26-21/h1-6,11-14H,7-10,15H2,(H2,26,27,30)
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11.4 -47.2n/an/an/an/an/a7.437



King Fahd University of Petroleum & Minerals



Assay Description
Human-cloned 5-HT1A serotonin receptors stably expressed in HEK293-EBNA cells (Perkin-Elmer, Waltham, MA) were radiolabeled with 1.0nM [3H]-8-OH-DPAT...


J Enzyme Inhib Med Chem 29: 281-91 (2014)


Article DOI: 10.3109/14756366.2013.776556
BindingDB Entry DOI: 10.7270/Q2SN07WV
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM29552
PNG
(benzimidazolone scaffold, 15j)
Show SMILES COc1ccccc1N1CCN(CCCCCCn2c3ccccc3[nH]c2=O)CC1
Show InChI InChI=1S/C24H32N4O2/c1-30-23-13-7-6-12-22(23)27-18-16-26(17-19-27)14-8-2-3-9-15-28-21-11-5-4-10-20(21)25-24(28)29/h4-7,10-13H,2-3,8-9,14-19H2,1H3,(H,25,29)
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12 -47.0n/an/an/an/an/a7.437



CNRS



Assay Description
Competition experiments were performed in the presence radioligand with membrane protein and test compounds. After incubation, the reaction stopped b...


Bioorg Med Chem Lett 19: 1600-3 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.008
BindingDB Entry DOI: 10.7270/Q2KS6PW1
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM248045
PNG
(5-(1-((4'-Fluorobiphenyl-4-yl)methyl)piperidin...)
Show SMILES Fc1ccc(cc1)-c1ccc(CN2CCC(CC2)c2ccc3[nH]c(=O)[nH]c3c2)cc1
Show InChI InChI=1S/C25H24FN3O/c26-22-8-5-19(6-9-22)18-3-1-17(2-4-18)16-29-13-11-20(12-14-29)21-7-10-23-24(15-21)28-25(30)27-23/h1-10,15,20H,11-14,16H2,(H2,27,28,30)
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16.2 -46.3n/an/an/an/an/a7.437



King Fahd University of Petroleum & Minerals



Assay Description
Human-cloned 5-HT1A serotonin receptors stably expressed in HEK293-EBNA cells (Perkin-Elmer, Waltham, MA) were radiolabeled with 1.0nM [3H]-8-OH-DPAT...


J Enzyme Inhib Med Chem 29: 281-91 (2014)


Article DOI: 10.3109/14756366.2013.776556
BindingDB Entry DOI: 10.7270/Q2SN07WV
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM29556
PNG
(1-(m-trifluorophenyl)piperazine, 3)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(CCCCN2C(=O)CCC2=O)CC1
Show InChI InChI=1S/C19H24F3N3O2/c20-19(21,22)15-4-3-5-16(14-15)24-12-10-23(11-13-24)8-1-2-9-25-17(26)6-7-18(25)27/h3-5,14H,1-2,6-13H2
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21 -45.6n/an/an/an/an/a7.437



Polish Academy of Science



Assay Description
Competition experiments were performed in the presence radioligand with membrane protein and test compounds. After incubation, the reaction stopped b...


Bioorg Med Chem 15: 7116-25 (2007)


Article DOI: 10.1016/j.bmc.2007.07.029
BindingDB Entry DOI: 10.7270/Q2G15Z6G
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM29540
PNG
(benzimidazolone scaffold, 8h)
Show SMILES COc1ccc(cc1)-n1c2ccccc2n(CCN2CCN(CC2)c2ccccc2OC)c1=O
Show InChI InChI=1S/C27H30N4O3/c1-33-22-13-11-21(12-14-22)31-24-8-4-3-7-23(24)30(27(31)32)20-17-28-15-18-29(19-16-28)25-9-5-6-10-26(25)34-2/h3-14H,15-20H2,1-2H3
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22 -45.5n/an/an/an/an/a7.437



CNRS



Assay Description
Competition experiments were performed in the presence radioligand with membrane protein and test compounds. After incubation, the reaction stopped b...


Bioorg Med Chem Lett 19: 1600-3 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.008
BindingDB Entry DOI: 10.7270/Q2KS6PW1
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM29544
PNG
(benzimidazolone scaffold, 15b)
Show SMILES COc1ccccc1N1CCN(CCn2c3ccccc3[nH]c2=O)CC1
Show InChI InChI=1S/C20H24N4O2/c1-26-19-9-5-4-8-18(19)23-13-10-22(11-14-23)12-15-24-17-7-3-2-6-16(17)21-20(24)25/h2-9H,10-15H2,1H3,(H,21,25)
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25 -45.1n/an/an/an/an/a7.437



CNRS



Assay Description
Competition experiments were performed in the presence radioligand with membrane protein and test compounds. After incubation, the reaction stopped b...


Bioorg Med Chem Lett 19: 1600-3 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.008
BindingDB Entry DOI: 10.7270/Q2KS6PW1
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM29545
PNG
(benzimidazolone scaffold, 15c)
Show SMILES O=c1[nH]c2ccccc2n1CCCN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C20H24N4O/c25-20-21-18-9-4-5-10-19(18)24(20)12-6-11-22-13-15-23(16-14-22)17-7-2-1-3-8-17/h1-5,7-10H,6,11-16H2,(H,21,25)
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26 -45.0n/an/an/an/an/a7.437



CNRS



Assay Description
Competition experiments were performed in the presence radioligand with membrane protein and test compounds. After incubation, the reaction stopped b...


Bioorg Med Chem Lett 19: 1600-3 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.008
BindingDB Entry DOI: 10.7270/Q2KS6PW1
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM29541
PNG
(benzimidazolone scaffold, 17d)
Show SMILES COc1ccc(cc1)-n1c2ccccc2n(CCCN2CCN(CC2)c2ccccc2OC)c1=O
Show InChI InChI=1S/C28H32N4O3/c1-34-23-14-12-22(13-15-23)32-25-9-4-3-8-24(25)31(28(32)33)17-7-16-29-18-20-30(21-19-29)26-10-5-6-11-27(26)35-2/h3-6,8-15H,7,16-21H2,1-2H3
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26 -45.0n/an/an/an/an/a7.437



CNRS



Assay Description
Competition experiments were performed in the presence radioligand with membrane protein and test compounds. After incubation, the reaction stopped b...


Bioorg Med Chem Lett 19: 1600-3 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.008
BindingDB Entry DOI: 10.7270/Q2KS6PW1
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM248051
PNG
(5-(4-((4'-fluorobiphenyl-4-yl)methyl)piperazin...)
Show SMILES Fc1ccc(cc1)-c1ccc(CN2CCN(CC2)c2ccc3[nH]c(=O)[nH]c3c2)cc1
Show InChI InChI=1S/C24H23FN4O/c25-20-7-5-19(6-8-20)18-3-1-17(2-4-18)16-28-11-13-29(14-12-28)21-9-10-22-23(15-21)27-24(30)26-22/h1-10,15H,11-14,16H2,(H2,26,27,30)
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27.2 -44.9n/an/an/an/an/a7.437



King Fahd University of Petroleum & Minerals



Assay Description
Human-cloned 5-HT1A serotonin receptors stably expressed in HEK293-EBNA cells (Perkin-Elmer, Waltham, MA) were radiolabeled with 1.0nM [3H]-8-OH-DPAT...


J Enzyme Inhib Med Chem 29: 281-91 (2014)


Article DOI: 10.3109/14756366.2013.776556
BindingDB Entry DOI: 10.7270/Q2SN07WV
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM29550
PNG
(benzimidazolone scaffold, 15h)
Show SMILES COc1ccccc1N1CCN(CCCCCn2c3ccccc3[nH]c2=O)CC1
Show InChI InChI=1S/C23H30N4O2/c1-29-22-12-6-5-11-21(22)26-17-15-25(16-18-26)13-7-2-8-14-27-20-10-4-3-9-19(20)24-23(27)28/h3-6,9-12H,2,7-8,13-18H2,1H3,(H,24,28)
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33 -44.4n/an/an/an/an/a7.437



CNRS



Assay Description
Competition experiments were performed in the presence radioligand with membrane protein and test compounds. After incubation, the reaction stopped b...


Bioorg Med Chem Lett 19: 1600-3 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.008
BindingDB Entry DOI: 10.7270/Q2KS6PW1
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM29564
PNG
(1-(m-trifluorophenyl)piperazine, 11)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(CCCCN2C(=O)C3CC=CCC3C2=O)CC1
Show InChI InChI=1S/C23H28F3N3O2/c24-23(25,26)17-6-5-7-18(16-17)28-14-12-27(13-15-28)10-3-4-11-29-21(30)19-8-1-2-9-20(19)22(29)31/h1-2,5-7,16,19-20H,3-4,8-15H2
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34 -44.3n/an/an/an/an/a7.437



Polish Academy of Science



Assay Description
Competition experiments were performed in the presence radioligand with membrane protein and test compounds. After incubation, the reaction stopped b...


Bioorg Med Chem 15: 7116-25 (2007)


Article DOI: 10.1016/j.bmc.2007.07.029
BindingDB Entry DOI: 10.7270/Q2G15Z6G
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM248044
PNG
(5-(1-(biphenyl-4-ylmethyl)piperidin-4-yl)-1H-benzo...)
Show SMILES O=c1[nH]c2ccc(cc2[nH]1)C1CCN(Cc2ccc(cc2)-c2ccccc2)CC1
Show InChI InChI=1S/C25H25N3O/c29-25-26-23-11-10-22(16-24(23)27-25)21-12-14-28(15-13-21)17-18-6-8-20(9-7-18)19-4-2-1-3-5-19/h1-11,16,21H,12-15,17H2,(H2,26,27,29)
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34.2 -44.3n/an/an/an/an/a7.437



King Fahd University of Petroleum & Minerals



Assay Description
Human-cloned 5-HT1A serotonin receptors stably expressed in HEK293-EBNA cells (Perkin-Elmer, Waltham, MA) were radiolabeled with 1.0nM [3H]-8-OH-DPAT...


J Enzyme Inhib Med Chem 29: 281-91 (2014)


Article DOI: 10.3109/14756366.2013.776556
BindingDB Entry DOI: 10.7270/Q2SN07WV
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM29542
PNG
(benzimidazolone scaffold, 17f)
Show SMILES COc1ccc(cc1)-n1c2ccccc2n(CCCCN2CCN(CC2)c2ccccc2OC)c1=O
Show InChI InChI=1S/C29H34N4O3/c1-35-24-15-13-23(14-16-24)33-26-10-4-3-9-25(26)32(29(33)34)18-8-7-17-30-19-21-31(22-20-30)27-11-5-6-12-28(27)36-2/h3-6,9-16H,7-8,17-22H2,1-2H3
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36 -44.2n/an/an/an/an/a7.437



CNRS



Assay Description
Competition experiments were performed in the presence radioligand with membrane protein and test compounds. After incubation, the reaction stopped b...


Bioorg Med Chem Lett 19: 1600-3 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.008
BindingDB Entry DOI: 10.7270/Q2KS6PW1
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM248050
PNG
(5-(4-(biphenyl-4-ylmethyl)piperazin-1-yl)-1H-benzo...)
Show SMILES O=c1[nH]c2ccc(cc2[nH]1)N1CCN(Cc2ccc(cc2)-c2ccccc2)CC1
Show InChI InChI=1S/C24H24N4O/c29-24-25-22-11-10-21(16-23(22)26-24)28-14-12-27(13-15-28)17-18-6-8-20(9-7-18)19-4-2-1-3-5-19/h1-11,16H,12-15,17H2,(H2,25,26,29)
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46.3 -43.5n/an/an/an/an/a7.437



King Fahd University of Petroleum & Minerals



Assay Description
Human-cloned 5-HT1A serotonin receptors stably expressed in HEK293-EBNA cells (Perkin-Elmer, Waltham, MA) were radiolabeled with 1.0nM [3H]-8-OH-DPAT...


J Enzyme Inhib Med Chem 29: 281-91 (2014)


Article DOI: 10.3109/14756366.2013.776556
BindingDB Entry DOI: 10.7270/Q2SN07WV
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM29551
PNG
(benzimidazolone scaffold, 15i)
Show SMILES O=c1[nH]c2ccccc2n1CCCCCCN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C23H30N4O/c28-23-24-21-12-6-7-13-22(21)27(23)15-9-2-1-8-14-25-16-18-26(19-17-25)20-10-4-3-5-11-20/h3-7,10-13H,1-2,8-9,14-19H2,(H,24,28)
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48 -43.5n/an/an/an/an/a7.437



CNRS



Assay Description
Competition experiments were performed in the presence radioligand with membrane protein and test compounds. After incubation, the reaction stopped b...


Bioorg Med Chem Lett 19: 1600-3 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.008
BindingDB Entry DOI: 10.7270/Q2KS6PW1
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM29553
PNG
(benzimidazolone scaffold, 15k)
Show SMILES Clc1cccc(c1)N1CCN(CCCCCn2c3ccccc3[nH]c2=O)CC1
Show InChI InChI=1S/C22H27ClN4O/c23-18-7-6-8-19(17-18)26-15-13-25(14-16-26)11-4-1-5-12-27-21-10-3-2-9-20(21)24-22(27)28/h2-3,6-10,17H,1,4-5,11-16H2,(H,24,28)
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66 -42.6n/an/an/an/an/a7.437



CNRS



Assay Description
Competition experiments were performed in the presence radioligand with membrane protein and test compounds. After incubation, the reaction stopped b...


Bioorg Med Chem Lett 19: 1600-3 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.008
BindingDB Entry DOI: 10.7270/Q2KS6PW1
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM29547
PNG
(benzimidazolone scaffold, 15e)
Show SMILES O=c1[nH]c2ccccc2n1CCCCN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C21H26N4O/c26-21-22-19-10-4-5-11-20(19)25(21)13-7-6-12-23-14-16-24(17-15-23)18-8-2-1-3-9-18/h1-5,8-11H,6-7,12-17H2,(H,22,26)
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84 -42.0n/an/an/an/an/a7.437



CNRS



Assay Description
Competition experiments were performed in the presence radioligand with membrane protein and test compounds. After incubation, the reaction stopped b...


Bioorg Med Chem Lett 19: 1600-3 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.008
BindingDB Entry DOI: 10.7270/Q2KS6PW1
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM29537
PNG
(benzimidazolone scaffold, 8e)
Show SMILES Cc1ccccc1N1CCN(CCn2c3ccccc3n(-c3ccccc3)c2=O)CC1
Show InChI InChI=1S/C26H28N4O/c1-21-9-5-6-12-23(21)28-18-15-27(16-19-28)17-20-29-24-13-7-8-14-25(24)30(26(29)31)22-10-3-2-4-11-22/h2-14H,15-20H2,1H3
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168 -40.2n/an/an/an/an/a7.437



CNRS



Assay Description
Competition experiments were performed in the presence radioligand with membrane protein and test compounds. After incubation, the reaction stopped b...


Bioorg Med Chem Lett 19: 1600-3 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.008
BindingDB Entry DOI: 10.7270/Q2KS6PW1
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM29539
PNG
(benzimidazolone scaffold, 8g)
Show SMILES COc1cccc(c1)-n1c2ccccc2n(CCN2CCN(CC2)c2ccccc2C)c1=O
Show InChI InChI=1S/C27H30N4O2/c1-21-8-3-4-11-24(21)29-17-14-28(15-18-29)16-19-30-25-12-5-6-13-26(25)31(27(30)32)22-9-7-10-23(20-22)33-2/h3-13,20H,14-19H2,1-2H3
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182 -40.0n/an/an/an/an/a7.437



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Assay Description
Competition experiments were performed in the presence radioligand with membrane protein and test compounds. After incubation, the reaction stopped b...


Bioorg Med Chem Lett 19: 1600-3 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.008
BindingDB Entry DOI: 10.7270/Q2KS6PW1
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM29549
PNG
(benzimidazolone scaffold, 15g)
Show SMILES O=c1[nH]c2ccccc2n1CCCCCN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C22H28N4O/c27-22-23-20-11-5-6-12-21(20)26(22)14-8-2-7-13-24-15-17-25(18-16-24)19-9-3-1-4-10-19/h1,3-6,9-12H,2,7-8,13-18H2,(H,23,27)
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269 -39.0n/an/an/an/an/a7.437



CNRS



Assay Description
Competition experiments were performed in the presence radioligand with membrane protein and test compounds. After incubation, the reaction stopped b...


Bioorg Med Chem Lett 19: 1600-3 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.008
BindingDB Entry DOI: 10.7270/Q2KS6PW1
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM29536
PNG
(benzimidazolone scaffold, 8d)
Show SMILES COc1ccc(cc1)-n1c2ccccc2n(CCN2CCN(CC2)c2ccccc2)c1=O
Show InChI InChI=1S/C26H28N4O2/c1-32-23-13-11-22(12-14-23)30-25-10-6-5-9-24(25)29(26(30)31)20-17-27-15-18-28(19-16-27)21-7-3-2-4-8-21/h2-14H,15-20H2,1H3
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340 -38.4n/an/an/an/an/a7.437



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Assay Description
Competition experiments were performed in the presence radioligand with membrane protein and test compounds. After incubation, the reaction stopped b...


Bioorg Med Chem Lett 19: 1600-3 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.008
BindingDB Entry DOI: 10.7270/Q2KS6PW1
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM29538
PNG
(benzimidazolone scaffold, 8f)
Show SMILES Cc1ccccc1N1CCN(CCn2c3ccccc3n(-c3ccccc3C)c2=O)CC1
Show InChI InChI=1S/C27H30N4O/c1-21-9-3-5-11-23(21)29-18-15-28(16-19-29)17-20-30-25-13-7-8-14-26(25)31(27(30)32)24-12-6-4-10-22(24)2/h3-14H,15-20H2,1-2H3
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375 -38.2n/an/an/an/an/a7.437



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Assay Description
Competition experiments were performed in the presence radioligand with membrane protein and test compounds. After incubation, the reaction stopped b...


Bioorg Med Chem Lett 19: 1600-3 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.008
BindingDB Entry DOI: 10.7270/Q2KS6PW1
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM29543
PNG
(benzimidazolone scaffold, 15a)
Show SMILES O=c1[nH]c2ccccc2n1CCN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C19H22N4O/c24-19-20-17-8-4-5-9-18(17)23(19)15-12-21-10-13-22(14-11-21)16-6-2-1-3-7-16/h1-9H,10-15H2,(H,20,24)
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392 -38.0n/an/an/an/an/a7.437



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Assay Description
Competition experiments were performed in the presence radioligand with membrane protein and test compounds. After incubation, the reaction stopped b...


Bioorg Med Chem Lett 19: 1600-3 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.008
BindingDB Entry DOI: 10.7270/Q2KS6PW1
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM29554
PNG
(benzimidazolone scaffold, 15m)
Show SMILES Clc1ccc(cc1)N1CCN(CCCCCn2c3ccccc3[nH]c2=O)CC1
Show InChI InChI=1S/C22H27ClN4O/c23-18-8-10-19(11-9-18)26-16-14-25(15-17-26)12-4-1-5-13-27-21-7-3-2-6-20(21)24-22(27)28/h2-3,6-11H,1,4-5,12-17H2,(H,24,28)
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454 -37.7n/an/an/an/an/a7.437



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Assay Description
Competition experiments were performed in the presence radioligand with membrane protein and test compounds. After incubation, the reaction stopped b...


Bioorg Med Chem Lett 19: 1600-3 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.008
BindingDB Entry DOI: 10.7270/Q2KS6PW1
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM29533
PNG
(benzimidazolone scaffold, 8a)
Show SMILES O=c1n(CCN2CCN(CC2)c2ccccc2)c2ccccc2n1-c1ccccc1
Show InChI InChI=1S/C25H26N4O/c30-25-28(20-17-26-15-18-27(19-16-26)21-9-3-1-4-10-21)23-13-7-8-14-24(23)29(25)22-11-5-2-6-12-22/h1-14H,15-20H2
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467 -37.6n/an/an/an/an/a7.437



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Assay Description
Competition experiments were performed in the presence radioligand with membrane protein and test compounds. After incubation, the reaction stopped b...


Bioorg Med Chem Lett 19: 1600-3 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.008
BindingDB Entry DOI: 10.7270/Q2KS6PW1
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM29534
PNG
(benzimidazolone scaffold, 8b)
Show SMILES Cc1ccccc1-n1c2ccccc2n(CCN2CCN(CC2)c2ccccc2)c1=O
Show InChI InChI=1S/C26H28N4O/c1-21-9-5-6-12-23(21)30-25-14-8-7-13-24(25)29(26(30)31)20-17-27-15-18-28(19-16-27)22-10-3-2-4-11-22/h2-14H,15-20H2,1H3
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636 -36.8n/an/an/an/an/a7.437



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Assay Description
Competition experiments were performed in the presence radioligand with membrane protein and test compounds. After incubation, the reaction stopped b...


Bioorg Med Chem Lett 19: 1600-3 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.008
BindingDB Entry DOI: 10.7270/Q2KS6PW1
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM29535
PNG
(benzimidazolone scaffold, 8c)
Show SMILES COc1cccc(c1)-n1c2ccccc2n(CCN2CCN(CC2)c2ccccc2)c1=O
Show InChI InChI=1S/C26H28N4O2/c1-32-23-11-7-10-22(20-23)30-25-13-6-5-12-24(25)29(26(30)31)19-16-27-14-17-28(18-15-27)21-8-3-2-4-9-21/h2-13,20H,14-19H2,1H3
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646 -36.8n/an/an/an/an/a7.437



CNRS



Assay Description
Competition experiments were performed in the presence radioligand with membrane protein and test compounds. After incubation, the reaction stopped b...


Bioorg Med Chem Lett 19: 1600-3 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.008
BindingDB Entry DOI: 10.7270/Q2KS6PW1
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM28580
PNG
(1-sulfonylindazole, 7b | N-[1-(naphthalene-1-sulfo...)
Show SMILES O=C(Nc1ccc2cnn(c2c1)S(=O)(=O)c1cccc2ccccc12)C1CCCNC1
Show InChI InChI=1S/C23H22N4O3S/c28-23(18-7-4-12-24-14-18)26-19-11-10-17-15-25-27(21(17)13-19)31(29,30)22-9-3-6-16-5-1-2-8-20(16)22/h1-3,5-6,8-11,13,15,18,24H,4,7,12,14H2,(H,26,28)
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5.60E+3 -29.7n/an/an/an/an/a7.422



Wyeth Research



Assay Description
Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...


Bioorg Med Chem Lett 19: 2413-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.071
BindingDB Entry DOI: 10.7270/Q28K77CF
More data for this
Ligand-Target Pair
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