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Found 10716 hits Enz. Inhib. hit(s) with Target = '5-hydroxytryptamine receptor 1A (5-HT1A)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (human))
BDBM264121
PNG
(3-(3-(4-(4-(4-oxofuro[3,2-c]pyridin-5 (4H)-yl)phen...)
Show SMILES O=c1n(ccc2occc12)-c1ccc(cc1)N1CCN(CCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C29H27N5O2/c30-19-21-3-8-27-26(18-21)22(20-31-27)2-1-11-32-13-15-33(16-14-32)23-4-6-24(7-5-23)34-12-9-28-25(29(34)35)10-17-36-28/h3-10,12,17-18,20,31H,1-2,11,13-16H2
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0.100n/an/an/an/an/an/a7.4n/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (human))
BDBM264120
PNG
(3-(4-(4-(4-(4-oxofuro[3,2-c]pyridin-5 (4H)-yl)phen...)
Show SMILES O=c1n(ccc2occc12)-c1ccc(cc1)N1CCN(CCCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C30H29N5O2/c31-20-22-4-9-28-27(19-22)23(21-32-28)3-1-2-12-33-14-16-34(17-15-33)24-5-7-25(8-6-24)35-13-10-29-26(30(35)36)11-18-37-29/h4-11,13,18-19,21,32H,1-3,12,14-17H2
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0.140n/an/an/an/an/an/a7.4n/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (human))
BDBM264112
PNG
(3-(4-(4-(4-(3,5-difluoro-2-oxopyridin-1(2H)-yl)phe...)
Show SMILES Fc1cc(F)c(=O)n(c1)-c1ccc(cc1)N1CCN(CCCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C28H27F2N5O/c29-22-16-26(30)28(36)35(19-22)24-7-5-23(6-8-24)34-13-11-33(12-14-34)10-2-1-3-21-18-32-27-9-4-20(17-31)15-25(21)27/h4-9,15-16,18-19,32H,1-3,10-14H2
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0.180n/an/an/an/an/an/a7.4n/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (human))
BDBM264097
PNG
(1-(4-(4-(4-(5-fluoro-1H-indol-3-yl)butyl)piperazin...)
Show SMILES Fc1ccc2[nH]cc(CCCCN3CCN(CC3)c3ccc(cc3)-n3ccccc3=O)c2c1
Show InChI InChI=1S/C27H29FN4O/c28-22-7-12-26-25(19-22)21(20-29-26)5-1-3-13-30-15-17-31(18-16-30)23-8-10-24(11-9-23)32-14-4-2-6-27(32)33/h2,4,6-12,14,19-20,29H,1,3,5,13,15-18H2
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0.190n/an/an/an/an/an/a7.4n/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (human))
BDBM50207158
PNG
(CHEMBL3982486 | US9550741, III-2)
Show SMILES CCOC(=O)N[C@H]1CC[C@H](CCN2CCN(CC2)c2nsc3ccccc23)CC1
Show InChI InChI=1S/C22H32N4O2S/c1-2-28-22(27)23-18-9-7-17(8-10-18)11-12-25-13-15-26(16-14-25)21-19-5-3-4-6-20(19)29-24-21/h3-6,17-18H,2,7-16H2,1H3,(H,23,27)/t17-,18-
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US Patent
0.200n/an/an/an/an/an/a7.4n/a



Shanghai Institute of Pharmaceutical Industry

US Patent


Assay Description
1. Experimental Materials:The isotopic ligand of 5-H1A receptor [3H]0.8-OH-DPAT (purchased from PE Corporation), (+)5-hydroxytryptamine (purchased fr...


US Patent US9550741 (2017)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (human))
BDBM263392
PNG
(US9550741, II-2)
Show SMILES O=S(=O)(N[C@H]1CC[C@H](CCN2CCN(CC2)c2nsc3ccccc23)CC1)c1cc[nH]c1
Show InChI InChI=1S/C23H31N5O2S2/c29-32(30,20-9-11-24-17-20)26-19-7-5-18(6-8-19)10-12-27-13-15-28(16-14-27)23-21-3-1-2-4-22(21)31-25-23/h1-4,9,11,17-19,24,26H,5-8,10,12-16H2/t18-,19-
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0.200n/an/an/an/an/an/a7.4n/a



Shanghai Institute of Pharmaceutical Industry

US Patent


Assay Description
1. Experimental Materials:The isotopic ligand of 5-H1A receptor [3H]0.8-OH-DPAT (purchased from PE Corporation), (+)5-hydroxytryptamine (purchased fr...


US Patent US9550741 (2017)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (human))
BDBM264096
PNG
(3-(4-(4-(4-(2-oxopyridin-1(2H)-yl)phenyl)piperazin...)
Show SMILES O=c1ccccn1-c1ccc(cc1)N1CCN(CCCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C28H29N5O/c29-20-22-7-12-27-26(19-22)23(21-30-27)5-1-3-13-31-15-17-32(18-16-31)24-8-10-25(11-9-24)33-14-4-2-6-28(33)34/h2,4,6-12,14,19,21,30H,1,3,5,13,15-18H2
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0.230n/an/an/an/an/an/a7.4n/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM29563
PNG
(1-(m-trifluorophenyl)piperazine, 10)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(CC1)C1CCC(CC1)N1C(=O)C2=C(CCCC2)C1=O
Show InChI InChI=1S/C25H30F3N3O2/c26-25(27,28)17-4-3-5-20(16-17)30-14-12-29(13-15-30)18-8-10-19(11-9-18)31-23(32)21-6-1-2-7-22(21)24(31)33/h3-5,16,18-19H,1-2,6-15H2
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PubMed
0.300 -56.5n/an/an/an/an/a7.437



Polish Academy of Science



Assay Description
Competition experiments were performed in the presence radioligand with membrane protein and test compounds. After incubation, the reaction stopped b...


Bioorg Med Chem 15: 7116-25 (2007)


Article DOI: 10.1016/j.bmc.2007.07.029
BindingDB Entry DOI: 10.7270/Q2G15Z6G
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (human))
BDBM264113
PNG
(3-(3-(4-(4-(3,5-difluoro-2-oxopyridin-1(2H)-yl)phe...)
Show SMILES Fc1cc(F)c(=O)n(c1)-c1ccc(cc1)N1CCN(CCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C27H25F2N5O/c28-21-15-25(29)27(35)34(18-21)23-6-4-22(5-7-23)33-12-10-32(11-13-33)9-1-2-20-17-31-26-8-3-19(16-30)14-24(20)26/h3-8,14-15,17-18,31H,1-2,9-13H2
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0.310n/an/an/an/an/an/a7.4n/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (human))
BDBM264104
PNG
(3-(4-(4-(4-(4-methyl-2-oxopyridin-1(2H)-yl)phenyl)...)
Show SMILES Cc1ccn(-c2ccc(cc2)N2CCN(CCCCc3c[nH]c4ccc(cc34)C#N)CC2)c(=O)c1
Show InChI InChI=1S/C29H31N5O/c1-22-11-13-34(29(35)18-22)26-8-6-25(7-9-26)33-16-14-32(15-17-33)12-3-2-4-24-21-31-28-10-5-23(20-30)19-27(24)28/h5-11,13,18-19,21,31H,2-4,12,14-17H2,1H3
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0.480n/an/an/an/an/an/a7.4n/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (human))
BDBM264118
PNG
(3-(4-(4-(4-(5-oxo-1,6-naphthyridin-6(5H)-yl)phenyl...)
Show SMILES O=c1n(ccc2ncccc12)-c1ccc(cc1)N1CCN(CCCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C31H30N6O/c32-21-23-6-11-29-28(20-23)24(22-34-29)4-1-2-14-35-16-18-36(19-17-35)25-7-9-26(10-8-25)37-15-12-30-27(31(37)38)5-3-13-33-30/h3,5-13,15,20,22,34H,1-2,4,14,16-19H2
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0.5n/an/an/an/an/an/a7.4n/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (human))
BDBM50207156
PNG
(CHEMBL3938210 | US9550741, I-3)
Show SMILES O=C(N[C@H]1CC[C@H](CCN2CCN(CC2)c2nsc3ccccc23)CC1)c1ccc[nH]1
Show InChI InChI=1S/C24H31N5OS/c30-24(21-5-3-12-25-21)26-19-9-7-18(8-10-19)11-13-28-14-16-29(17-15-28)23-20-4-1-2-6-22(20)31-27-23/h1-6,12,18-19,25H,7-11,13-17H2,(H,26,30)/t18-,19-
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0.520n/an/an/an/an/an/a7.4n/a



Shanghai Institute of Pharmaceutical Industry

US Patent


Assay Description
1. Experimental Materials:The isotopic ligand of 5-H1A receptor [3H]0.8-OH-DPAT (purchased from PE Corporation), (+)5-hydroxytryptamine (purchased fr...


US Patent US9550741 (2017)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (human))
BDBM50207156
PNG
(CHEMBL3938210 | US9550741, I-3)
Show SMILES O=C(N[C@H]1CC[C@H](CCN2CCN(CC2)c2nsc3ccccc23)CC1)c1ccc[nH]1
Show InChI InChI=1S/C24H31N5OS/c30-24(21-5-3-12-25-21)26-19-9-7-18(8-10-19)11-13-28-14-16-29(17-15-28)23-20-4-1-2-6-22(20)31-27-23/h1-6,12,18-19,25H,7-11,13-17H2,(H,26,30)/t18-,19-
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US Patent
0.520n/an/an/an/an/an/a7.4n/a



Shanghai Institute of Pharmaceutical Industry

US Patent


Assay Description
1. Experimental Materials:The isotopic ligand of 5-H1A receptor [3H]0.8-OH-DPAT (purchased from PE Corporation), (+)5-hydroxytryptamine (purchased fr...


US Patent US9550741 (2017)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (human))
BDBM263396
PNG
(US9550741, II-6)
Show SMILES O=S(=O)(N[C@H]1CC[C@H](CCN2CCN(CC2)c2nsc3ccccc23)CC1)c1c[nH]c2ccccc12
Show InChI InChI=1S/C27H33N5O2S2/c33-36(34,26-19-28-24-7-3-1-5-22(24)26)30-21-11-9-20(10-12-21)13-14-31-15-17-32(18-16-31)27-23-6-2-4-8-25(23)35-29-27/h1-8,19-21,28,30H,9-18H2/t20-,21-
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0.580n/an/an/an/an/an/a7.4n/a



Shanghai Institute of Pharmaceutical Industry

US Patent


Assay Description
1. Experimental Materials:The isotopic ligand of 5-H1A receptor [3H]0.8-OH-DPAT (purchased from PE Corporation), (+)5-hydroxytryptamine (purchased fr...


US Patent US9550741 (2017)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (human))
BDBM263424
PNG
(US9550741, III-6)
Show SMILES O=C(N[C@H]1CC[C@H](CCN2CCN(CC2)c2nsc3ccccc23)CC1)Oc1ccccc1
Show InChI InChI=1S/C26H32N4O2S/c31-26(32-22-6-2-1-3-7-22)27-21-12-10-20(11-13-21)14-15-29-16-18-30(19-17-29)25-23-8-4-5-9-24(23)33-28-25/h1-9,20-21H,10-19H2,(H,27,31)/t20-,21-
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0.580n/an/an/an/an/an/a7.4n/a



Shanghai Institute of Pharmaceutical Industry

US Patent


Assay Description
1. Experimental Materials:The isotopic ligand of 5-H1A receptor [3H]0.8-OH-DPAT (purchased from PE Corporation), (+)5-hydroxytryptamine (purchased fr...


US Patent US9550741 (2017)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (human))
BDBM264109
PNG
(3-(3-(4-(4-(4-methoxy-2-oxopyridin-1(2H)-yl)phenyl...)
Show SMILES COc1ccn(-c2ccc(cc2)N2CCN(CCCc3c[nH]c4ccc(cc34)C#N)CC2)c(=O)c1
Show InChI InChI=1S/C28H29N5O2/c1-35-25-10-12-33(28(34)18-25)24-7-5-23(6-8-24)32-15-13-31(14-16-32)11-2-3-22-20-30-27-9-4-21(19-29)17-26(22)27/h4-10,12,17-18,20,30H,2-3,11,13-16H2,1H3
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0.610n/an/an/an/an/an/a7.4n/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (human))
BDBM263401
PNG
(US9550741, II-11)
Show SMILES Clc1ccc2sc(cc2c1)S(=O)(=O)N[C@H]1CC[C@H](CCN2CCN(CC2)c2nsc3ccccc23)CC1
Show InChI InChI=1S/C27H31ClN4O2S3/c28-21-7-10-24-20(17-21)18-26(35-24)37(33,34)30-22-8-5-19(6-9-22)11-12-31-13-15-32(16-14-31)27-23-3-1-2-4-25(23)36-29-27/h1-4,7,10,17-19,22,30H,5-6,8-9,11-16H2/t19-,22-
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0.790n/an/an/an/an/an/a7.4n/a



Shanghai Institute of Pharmaceutical Industry

US Patent


Assay Description
1. Experimental Materials:The isotopic ligand of 5-H1A receptor [3H]0.8-OH-DPAT (purchased from PE Corporation), (+)5-hydroxytryptamine (purchased fr...


US Patent US9550741 (2017)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (human))
BDBM263429
PNG
(US9550741, III-11)
Show SMILES O=C(N[C@H]1CC[C@H](CCN2CCN(CC2)c2nsc3ccccc23)CC1)OCc1ccccc1
Show InChI InChI=1S/C27H34N4O2S/c32-27(33-20-22-6-2-1-3-7-22)28-23-12-10-21(11-13-23)14-15-30-16-18-31(19-17-30)26-24-8-4-5-9-25(24)34-29-26/h1-9,21,23H,10-20H2,(H,28,32)/t21-,23-
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0.790n/an/an/an/an/an/a7.4n/a



Shanghai Institute of Pharmaceutical Industry

US Patent


Assay Description
1. Experimental Materials:The isotopic ligand of 5-H1A receptor [3H]0.8-OH-DPAT (purchased from PE Corporation), (+)5-hydroxytryptamine (purchased fr...


US Patent US9550741 (2017)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (human))
BDBM264122
PNG
(3-(4-(4-(4-(2-oxopyrazin-1(2H)-yl)phenyl)piperazin...)
Show SMILES O=c1cnccn1-c1ccc(cc1)N1CCN(CCCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C27H28N6O/c28-18-21-4-9-26-25(17-21)22(19-30-26)3-1-2-11-31-13-15-32(16-14-31)23-5-7-24(8-6-23)33-12-10-29-20-27(33)34/h4-10,12,17,19-20,30H,1-3,11,13-16H2
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0.800n/an/an/an/an/an/a7.4n/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (human))
BDBM264099
PNG
(1-(4-(4-(3-(5-fluoro-1H-indol-3-yl)propyl)piperazi...)
Show SMILES Fc1ccc2[nH]cc(CCCN3CCN(CC3)c3ccc(cc3)-n3ccccc3=O)c2c1
Show InChI InChI=1S/C26H27FN4O/c27-21-6-11-25-24(18-21)20(19-28-25)4-3-12-29-14-16-30(17-15-29)22-7-9-23(10-8-22)31-13-2-1-5-26(31)32/h1-2,5-11,13,18-19,28H,3-4,12,14-17H2
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0.870n/an/an/an/an/an/a7.4n/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (human))
BDBM264105
PNG
(3-(3-(4-(4-(4-methyl-2-oxopyridin-1(2H)-yl)phenyl)...)
Show SMILES Cc1ccn(-c2ccc(cc2)N2CCN(CCCc3c[nH]c4ccc(cc34)C#N)CC2)c(=O)c1
Show InChI InChI=1S/C28H29N5O/c1-21-10-12-33(28(34)17-21)25-7-5-24(6-8-25)32-15-13-31(14-16-32)11-2-3-23-20-30-27-9-4-22(19-29)18-26(23)27/h4-10,12,17-18,20,30H,2-3,11,13-16H2,1H3
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0.890n/an/an/an/an/an/a7.4n/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (human))
BDBM50207110
PNG
(CHEMBL3923240 | US9550741, III-15)
Show SMILES CCOC(=O)N[C@@H]1CC[C@H](CCN2CCN(CC2)c2nsc3ccccc23)CC1
Show InChI InChI=1S/C22H32N4O2S/c1-2-28-22(27)23-18-9-7-17(8-10-18)11-12-25-13-15-26(16-14-25)21-19-5-3-4-6-20(19)29-24-21/h3-6,17-18H,2,7-16H2,1H3,(H,23,27)/t17-,18+
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0.970n/an/an/an/an/an/a7.4n/a



Shanghai Institute of Pharmaceutical Industry

US Patent


Assay Description
1. Experimental Materials:The isotopic ligand of 5-H1A receptor [3H]0.8-OH-DPAT (purchased from PE Corporation), (+)5-hydroxytryptamine (purchased fr...


US Patent US9550741 (2017)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (human))
BDBM263405
PNG
(US9550741, II-15)
Show SMILES COc1ccc2sc(cc2c1)S(=O)(=O)N[C@H]1CC[C@H](CCN2CCN(CC2)c2nsc3ccccc23)CC1
Show InChI InChI=1S/C28H34N4O3S3/c1-35-23-10-11-25-21(18-23)19-27(36-25)38(33,34)30-22-8-6-20(7-9-22)12-13-31-14-16-32(17-15-31)28-24-4-2-3-5-26(24)37-29-28/h2-5,10-11,18-20,22,30H,6-9,12-17H2,1H3/t20-,22-
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0.970n/an/an/an/an/an/a7.4n/a



Shanghai Institute of Pharmaceutical Industry

US Patent


Assay Description
1. Experimental Materials:The isotopic ligand of 5-H1A receptor [3H]0.8-OH-DPAT (purchased from PE Corporation), (+)5-hydroxytryptamine (purchased fr...


US Patent US9550741 (2017)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (human))
BDBM263383
PNG
(US9550741, I-17)
Show SMILES O=C(Cc1cccs1)N[C@H]1CC[C@H](CCN2CCN(CC2)c2nsc3ccccc23)CC1
Show InChI InChI=1S/C25H32N4OS2/c30-24(18-21-4-3-17-31-21)26-20-9-7-19(8-10-20)11-12-28-13-15-29(16-14-28)25-22-5-1-2-6-23(22)32-27-25/h1-6,17,19-20H,7-16,18H2,(H,26,30)/t19-,20-
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0.980n/an/an/an/an/an/a7.4n/a



Shanghai Institute of Pharmaceutical Industry

US Patent


Assay Description
1. Experimental Materials:The isotopic ligand of 5-H1A receptor [3H]0.8-OH-DPAT (purchased from PE Corporation), (+)5-hydroxytryptamine (purchased fr...


US Patent US9550741 (2017)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (human))
BDBM263383
PNG
(US9550741, I-17)
Show SMILES O=C(Cc1cccs1)N[C@H]1CC[C@H](CCN2CCN(CC2)c2nsc3ccccc23)CC1
Show InChI InChI=1S/C25H32N4OS2/c30-24(18-21-4-3-17-31-21)26-20-9-7-19(8-10-20)11-12-28-13-15-29(16-14-28)25-22-5-1-2-6-23(22)32-27-25/h1-6,17,19-20H,7-16,18H2,(H,26,30)/t19-,20-
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0.980n/an/an/an/an/an/a7.4n/a



Shanghai Institute of Pharmaceutical Industry

US Patent


Assay Description
1. Experimental Materials:The isotopic ligand of 5-H1A receptor [3H]0.8-OH-DPAT (purchased from PE Corporation), (+)5-hydroxytryptamine (purchased fr...


US Patent US9550741 (2017)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (human))
BDBM50207094
PNG
(CHEMBL3976282 | US9550741, I-2)
Show SMILES O=C(N[C@H]1CC[C@H](CCN2CCN(CC2)c2nsc3ccccc23)CC1)c1cccs1
Show InChI InChI=1S/C24H30N4OS2/c29-24(22-6-3-17-30-22)25-19-9-7-18(8-10-19)11-12-27-13-15-28(16-14-27)23-20-4-1-2-5-21(20)31-26-23/h1-6,17-19H,7-16H2,(H,25,29)/t18-,19-
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1.10n/an/an/an/an/an/a7.4n/a



Shanghai Institute of Pharmaceutical Industry

US Patent


Assay Description
1. Experimental Materials:The isotopic ligand of 5-H1A receptor [3H]0.8-OH-DPAT (purchased from PE Corporation), (+)5-hydroxytryptamine (purchased fr...


US Patent US9550741 (2017)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (human))
BDBM50207094
PNG
(CHEMBL3976282 | US9550741, I-2)
Show SMILES O=C(N[C@H]1CC[C@H](CCN2CCN(CC2)c2nsc3ccccc23)CC1)c1cccs1
Show InChI InChI=1S/C24H30N4OS2/c29-24(22-6-3-17-30-22)25-19-9-7-18(8-10-19)11-12-27-13-15-28(16-14-27)23-20-4-1-2-5-21(20)31-26-23/h1-6,17-19H,7-16H2,(H,25,29)/t18-,19-
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1.10n/an/an/an/an/an/a7.4n/a



Shanghai Institute of Pharmaceutical Industry

US Patent


Assay Description
1. Experimental Materials:The isotopic ligand of 5-H1A receptor [3H]0.8-OH-DPAT (purchased from PE Corporation), (+)5-hydroxytryptamine (purchased fr...


US Patent US9550741 (2017)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (human))
BDBM263419
PNG
(US9550741, III-1)
Show SMILES COC(=O)N[C@H]1CC[C@H](CCN2CCN(CC2)c2nsc3ccccc23)CC1
Show InChI InChI=1S/C21H30N4O2S/c1-27-21(26)22-17-8-6-16(7-9-17)10-11-24-12-14-25(15-13-24)20-18-4-2-3-5-19(18)28-23-20/h2-5,16-17H,6-15H2,1H3,(H,22,26)/t16-,17-
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1.14n/an/an/an/an/an/a7.4n/a



Shanghai Institute of Pharmaceutical Industry

US Patent


Assay Description
1. Experimental Materials:The isotopic ligand of 5-H1A receptor [3H]0.8-OH-DPAT (purchased from PE Corporation), (+)5-hydroxytryptamine (purchased fr...


US Patent US9550741 (2017)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (human))
BDBM50207143
PNG
(CHEMBL3966842 | US9550741, II-1)
Show SMILES O=S(=O)(N[C@H]1CC[C@H](CCN2CCN(CC2)c2nsc3ccccc23)CC1)c1cccs1
Show InChI InChI=1S/C23H30N4O2S3/c28-32(29,22-6-3-17-30-22)25-19-9-7-18(8-10-19)11-12-26-13-15-27(16-14-26)23-20-4-1-2-5-21(20)31-24-23/h1-6,17-19,25H,7-16H2/t18-,19-
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1.14n/an/an/an/an/an/a7.4n/a



Shanghai Institute of Pharmaceutical Industry

US Patent


Assay Description
1. Experimental Materials:The isotopic ligand of 5-H1A receptor [3H]0.8-OH-DPAT (purchased from PE Corporation), (+)5-hydroxytryptamine (purchased fr...


US Patent US9550741 (2017)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (human))
BDBM264108
PNG
(3-(4-(4-(4-(4-methoxy-2-oxopyridin-1(2H)-yl)phenyl...)
Show SMILES COc1ccn(-c2ccc(cc2)N2CCN(CCCCc3c[nH]c4ccc(cc34)C#N)CC2)c(=O)c1
Show InChI InChI=1S/C29H31N5O2/c1-36-26-11-13-34(29(35)19-26)25-8-6-24(7-9-25)33-16-14-32(15-17-33)12-3-2-4-23-21-31-28-10-5-22(20-30)18-27(23)28/h5-11,13,18-19,21,31H,2-4,12,14-17H2,1H3
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1.20n/an/an/an/an/an/a7.4n/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (human))
BDBM248048
PNG
(5-(1-(3-cyclopentenylbenzyl)piperidin-4-yl)-1H-ben...)
Show SMILES O=c1[nH]c2ccc(cc2[nH]1)C1CCN(Cc2cccc(c2)C2=CCCC2)CC1
Show InChI InChI=1S/C24H27N3O/c28-24-25-22-9-8-21(15-23(22)26-24)19-10-12-27(13-11-19)16-17-4-3-7-20(14-17)18-5-1-2-6-18/h3-5,7-9,14-15,19H,1-2,6,10-13,16H2,(H2,25,26,28)
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1.20 -53.0n/an/an/an/an/a7.437



King Fahd University of Petroleum & Minerals



Assay Description
Human-cloned 5-HT1A serotonin receptors stably expressed in HEK293-EBNA cells (Perkin-Elmer, Waltham, MA) were radiolabeled with 1.0nM [3H]-8-OH-DPAT...


J Enzyme Inhib Med Chem 29: 281-91 (2014)


Article DOI: 10.3109/14756366.2013.776556
BindingDB Entry DOI: 10.7270/Q2SN07WV
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (human))
BDBM10755
PNG
(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Show SMILES NCCc1c[nH]c2ccc(O)cc12
Show InChI InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2
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1.20n/an/an/an/an/an/a7.4n/a



Jagiellonian University Medical College



Assay Description
Binding experiments were conducted in 96-well microplates in a total volume of 250 μL of buffer (50 mM Tris-HCl pH 7.4, 10 mM MgCl2, 0.5 mM EDTA...


Chem Biol Drug Des 89: 339-352 (2017)


Article DOI: 10.1111/cbdd.12842
BindingDB Entry DOI: 10.7270/Q2PN94GQ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (human))
BDBM264098
PNG
(3-(3-(4-(4-(2-oxopyridin-1(2H)-yl)phenyl)piperazin...)
Show SMILES O=c1ccccn1-c1ccc(cc1)N1CCN(CCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C27H27N5O/c28-19-21-6-11-26-25(18-21)22(20-29-26)4-3-12-30-14-16-31(17-15-30)23-7-9-24(10-8-23)32-13-2-1-5-27(32)33/h1-2,5-11,13,18,20,29H,3-4,12,14-17H2
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1.20n/an/an/an/an/an/a7.4n/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (human))
BDBM264091
PNG
(3-(3-(4-(4-(2-oxopiperidin-1-yl)phenyl)piperazin-1...)
Show SMILES O=C1CCCCN1c1ccc(cc1)N1CCN(CCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C27H31N5O/c28-19-21-6-11-26-25(18-21)22(20-29-26)4-3-12-30-14-16-31(17-15-30)23-7-9-24(10-8-23)32-13-2-1-5-27(32)33/h6-11,18,20,29H,1-5,12-17H2
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1.20n/an/an/an/an/an/a7.4n/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (human))
BDBM50207145
PNG
(CHEMBL3946995 | US9550741, I-1)
Show SMILES O=C(N[C@H]1CC[C@H](CCN2CCN(CC2)c2nsc3ccccc23)CC1)c1ccco1
Show InChI InChI=1S/C24H30N4O2S/c29-24(21-5-3-17-30-21)25-19-9-7-18(8-10-19)11-12-27-13-15-28(16-14-27)23-20-4-1-2-6-22(20)31-26-23/h1-6,17-19H,7-16H2,(H,25,29)/t18-,19-
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1.30n/an/an/an/an/an/a7.4n/a



Shanghai Institute of Pharmaceutical Industry

US Patent


Assay Description
1. Experimental Materials:The isotopic ligand of 5-H1A receptor [3H]0.8-OH-DPAT (purchased from PE Corporation), (+)5-hydroxytryptamine (purchased fr...


US Patent US9550741 (2017)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (human))
BDBM264124
PNG
(3-(4-(4-(4-(2-oxotetrahydropyrimidin-1(2H)-yl)phen...)
Show SMILES O=C1NCCCN1c1ccc(cc1)N1CCN(CCCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C27H32N6O/c28-19-21-5-10-26-25(18-21)22(20-30-26)4-1-2-12-31-14-16-32(17-15-31)23-6-8-24(9-7-23)33-13-3-11-29-27(33)34/h5-10,18,20,30H,1-4,11-17H2,(H,29,34)
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1.30n/an/an/an/an/an/a7.4n/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (human))
BDBM50207145
PNG
(CHEMBL3946995 | US9550741, I-1)
Show SMILES O=C(N[C@H]1CC[C@H](CCN2CCN(CC2)c2nsc3ccccc23)CC1)c1ccco1
Show InChI InChI=1S/C24H30N4O2S/c29-24(21-5-3-17-30-21)25-19-9-7-18(8-10-19)11-12-27-13-15-28(16-14-27)23-20-4-1-2-6-22(20)31-26-23/h1-6,17-19H,7-16H2,(H,25,29)/t18-,19-
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1.30n/an/an/an/an/an/a7.4n/a



Shanghai Institute of Pharmaceutical Industry

US Patent


Assay Description
1. Experimental Materials:The isotopic ligand of 5-H1A receptor [3H]0.8-OH-DPAT (purchased from PE Corporation), (+)5-hydroxytryptamine (purchased fr...


US Patent US9550741 (2017)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM29567
PNG
(1-(m-trifluorophenyl)piperazine, 14)
Show SMILES CC1=C(C)C(=O)N(C2CCC(CC2)N2CCN(CC2)c2cccc(c2)C(F)(F)F)C1=O
Show InChI InChI=1S/C23H28F3N3O2/c1-15-16(2)22(31)29(21(15)30)19-8-6-18(7-9-19)27-10-12-28(13-11-27)20-5-3-4-17(14-20)23(24,25)26/h3-5,14,18-19H,6-13H2,1-2H3
KEGG

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1.30 -52.8n/an/an/an/an/a7.437



Polish Academy of Science



Assay Description
Competition experiments were performed in the presence radioligand with membrane protein and test compounds. After incubation, the reaction stopped b...


Bioorg Med Chem 15: 7116-25 (2007)


Article DOI: 10.1016/j.bmc.2007.07.029
BindingDB Entry DOI: 10.7270/Q2G15Z6G
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (human))
BDBM50207161
PNG
(CHEMBL3950977 | US9550741, I-19)
Show SMILES O=C(N[C@@H]1CC[C@H](CCN2CCN(CC2)c2nsc3ccccc23)CC1)c1ccco1
Show InChI InChI=1S/C24H30N4O2S/c29-24(21-5-3-17-30-21)25-19-9-7-18(8-10-19)11-12-27-13-15-28(16-14-27)23-20-4-1-2-6-22(20)31-26-23/h1-6,17-19H,7-16H2,(H,25,29)/t18-,19+
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1.37n/an/an/an/an/an/a7.4n/a



Shanghai Institute of Pharmaceutical Industry

US Patent


Assay Description
1. Experimental Materials:The isotopic ligand of 5-H1A receptor [3H]0.8-OH-DPAT (purchased from PE Corporation), (+)5-hydroxytryptamine (purchased fr...


US Patent US9550741 (2017)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (human))
BDBM50207161
PNG
(CHEMBL3950977 | US9550741, I-19)
Show SMILES O=C(N[C@@H]1CC[C@H](CCN2CCN(CC2)c2nsc3ccccc23)CC1)c1ccco1
Show InChI InChI=1S/C24H30N4O2S/c29-24(21-5-3-17-30-21)25-19-9-7-18(8-10-19)11-12-27-13-15-28(16-14-27)23-20-4-1-2-6-22(20)31-26-23/h1-6,17-19H,7-16H2,(H,25,29)/t18-,19+
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US Patent
1.37n/an/an/an/an/an/a7.4n/a



Shanghai Institute of Pharmaceutical Industry

US Patent


Assay Description
1. Experimental Materials:The isotopic ligand of 5-H1A receptor [3H]0.8-OH-DPAT (purchased from PE Corporation), (+)5-hydroxytryptamine (purchased fr...


US Patent US9550741 (2017)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM29565
PNG
(1-(m-trifluorophenyl)piperazine, 12)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(CC1)C1CCC(CC1)N1C(=O)C2CC=CCC2C1=O
Show InChI InChI=1S/C25H30F3N3O2/c26-25(27,28)17-4-3-5-20(16-17)30-14-12-29(13-15-30)18-8-10-19(11-9-18)31-23(32)21-6-1-2-7-22(21)24(31)33/h1-5,16,18-19,21-22H,6-15H2
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PubMed
1.5 -52.4n/an/an/an/an/a7.437



Polish Academy of Science



Assay Description
Competition experiments were performed in the presence radioligand with membrane protein and test compounds. After incubation, the reaction stopped b...


Bioorg Med Chem 15: 7116-25 (2007)


Article DOI: 10.1016/j.bmc.2007.07.029
BindingDB Entry DOI: 10.7270/Q2G15Z6G
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (human))
BDBM264115
PNG
(3-(5-(4-(4-(3,5-difluoro-2-oxopyridin-1(2H)-yl)phe...)
Show SMILES Fc1cc(F)c(=O)n(c1)-c1ccc(cc1)N1CCN(CCCCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C29H29F2N5O/c30-23-17-27(31)29(37)36(20-23)25-8-6-24(7-9-25)35-14-12-34(13-15-35)11-3-1-2-4-22-19-33-28-10-5-21(18-32)16-26(22)28/h5-10,16-17,19-20,33H,1-4,11-15H2
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1.5n/an/an/an/an/an/a7.4n/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (human))
BDBM263395
PNG
(US9550741, II-5)
Show SMILES O=S(=O)(N[C@H]1CC[C@H](CCN2CCN(CC2)c2nsc3ccccc23)CC1)c1cc2ccccc2o1
Show InChI InChI=1S/C27H32N4O3S2/c32-36(33,26-19-21-5-1-3-7-24(21)34-26)29-22-11-9-20(10-12-22)13-14-30-15-17-31(18-16-30)27-23-6-2-4-8-25(23)35-28-27/h1-8,19-20,22,29H,9-18H2/t20-,22-
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1.69n/an/an/an/an/an/a7.4n/a



Shanghai Institute of Pharmaceutical Industry

US Patent


Assay Description
1. Experimental Materials:The isotopic ligand of 5-H1A receptor [3H]0.8-OH-DPAT (purchased from PE Corporation), (+)5-hydroxytryptamine (purchased fr...


US Patent US9550741 (2017)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (human))
BDBM263423
PNG
(US9550741, III-5)
Show SMILES O=C(N[C@H]1CC[C@H](CCN2CCN(CC2)c2nsc3ccccc23)CC1)OC1CCCCC1
Show InChI InChI=1S/C26H38N4O2S/c31-26(32-22-6-2-1-3-7-22)27-21-12-10-20(11-13-21)14-15-29-16-18-30(19-17-29)25-23-8-4-5-9-24(23)33-28-25/h4-5,8-9,20-22H,1-3,6-7,10-19H2,(H,27,31)/t20-,21-
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1.69n/an/an/an/an/an/a7.4n/a



Shanghai Institute of Pharmaceutical Industry

US Patent


Assay Description
1. Experimental Materials:The isotopic ligand of 5-H1A receptor [3H]0.8-OH-DPAT (purchased from PE Corporation), (+)5-hydroxytryptamine (purchased fr...


US Patent US9550741 (2017)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (human))
BDBM264119
PNG
(3-(3-(4-(4-(5-oxo-1,6-naphthyridin-6(5H)-yl)phenyl...)
Show SMILES O=c1n(ccc2ncccc12)-c1ccc(cc1)N1CCN(CCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C30H28N6O/c31-20-22-5-10-28-27(19-22)23(21-33-28)3-2-13-34-15-17-35(18-16-34)24-6-8-25(9-7-24)36-14-11-29-26(30(36)37)4-1-12-32-29/h1,4-12,14,19,21,33H,2-3,13,15-18H2
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1.70n/an/an/an/an/an/a7.4n/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (human))
BDBM248055
PNG
(5-(4-((5-cyclopentenylpyridin-3-yl)methyl)piperazi...)
Show SMILES O=c1[nH]c2ccc(cc2[nH]1)N1CCN(Cc2cncc(c2)C2=CCCC2)CC1
Show InChI InChI=1S/C22H25N5O/c28-22-24-20-6-5-19(12-21(20)25-22)27-9-7-26(8-10-27)15-16-11-18(14-23-13-16)17-3-1-2-4-17/h3,5-6,11-14H,1-2,4,7-10,15H2,(H2,24,25,28)
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1.70 -52.1n/an/an/an/an/a7.437



King Fahd University of Petroleum & Minerals



Assay Description
Human-cloned 5-HT1A serotonin receptors stably expressed in HEK293-EBNA cells (Perkin-Elmer, Waltham, MA) were radiolabeled with 1.0nM [3H]-8-OH-DPAT...


J Enzyme Inhib Med Chem 29: 281-91 (2014)


Article DOI: 10.3109/14756366.2013.776556
BindingDB Entry DOI: 10.7270/Q2SN07WV
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (human))
BDBM263403
PNG
(US9550741, II-13)
Show SMILES Cc1ccc2sc(cc2c1)S(=O)(=O)N[C@H]1CC[C@H](CCN2CCN(CC2)c2nsc3ccccc23)CC1
Show InChI InChI=1S/C28H34N4O2S3/c1-20-6-11-25-22(18-20)19-27(35-25)37(33,34)30-23-9-7-21(8-10-23)12-13-31-14-16-32(17-15-31)28-24-4-2-3-5-26(24)36-29-28/h2-6,11,18-19,21,23,30H,7-10,12-17H2,1H3/t21-,23-
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1.76n/an/an/an/an/an/a7.4n/a



Shanghai Institute of Pharmaceutical Industry

US Patent


Assay Description
1. Experimental Materials:The isotopic ligand of 5-H1A receptor [3H]0.8-OH-DPAT (purchased from PE Corporation), (+)5-hydroxytryptamine (purchased fr...


US Patent US9550741 (2017)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (human))
BDBM263431
PNG
(US9550741, III-13)
Show SMILES O=C(N[C@H]1CC[C@H](CCN2CCN(CC2)c2nsc3ccccc23)CC1)OCc1cccs1
Show InChI InChI=1S/C25H32N4O2S2/c30-25(31-18-21-4-3-17-32-21)26-20-9-7-19(8-10-20)11-12-28-13-15-29(16-14-28)24-22-5-1-2-6-23(22)33-27-24/h1-6,17,19-20H,7-16,18H2,(H,26,30)/t19-,20-
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1.76n/an/an/an/an/an/a7.4n/a



Shanghai Institute of Pharmaceutical Industry

US Patent


Assay Description
1. Experimental Materials:The isotopic ligand of 5-H1A receptor [3H]0.8-OH-DPAT (purchased from PE Corporation), (+)5-hydroxytryptamine (purchased fr...


US Patent US9550741 (2017)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (human))
BDBM263375
PNG
(US9550741, I-9)
Show SMILES Cc1ccc([nH]1)C(=O)N[C@H]1CC[C@H](CCN2CCN(CC2)c2nsc3ccccc23)CC1
Show InChI InChI=1S/C25H33N5OS/c1-18-6-11-22(26-18)25(31)27-20-9-7-19(8-10-20)12-13-29-14-16-30(17-15-29)24-21-4-2-3-5-23(21)32-28-24/h2-6,11,19-20,26H,7-10,12-17H2,1H3,(H,27,31)/t19-,20-
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1.78n/an/an/an/an/an/a7.4n/a



Shanghai Institute of Pharmaceutical Industry

US Patent


Assay Description
1. Experimental Materials:The isotopic ligand of 5-H1A receptor [3H]0.8-OH-DPAT (purchased from PE Corporation), (+)5-hydroxytryptamine (purchased fr...


US Patent US9550741 (2017)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (human))
BDBM263375
PNG
(US9550741, I-9)
Show SMILES Cc1ccc([nH]1)C(=O)N[C@H]1CC[C@H](CCN2CCN(CC2)c2nsc3ccccc23)CC1
Show InChI InChI=1S/C25H33N5OS/c1-18-6-11-22(26-18)25(31)27-20-9-7-19(8-10-20)12-13-29-14-16-30(17-15-29)24-21-4-2-3-5-23(21)32-28-24/h2-6,11,19-20,26H,7-10,12-17H2,1H3,(H,27,31)/t19-,20-
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1.78n/an/an/an/an/an/a7.4n/a



Shanghai Institute of Pharmaceutical Industry

US Patent


Assay Description
1. Experimental Materials:The isotopic ligand of 5-H1A receptor [3H]0.8-OH-DPAT (purchased from PE Corporation), (+)5-hydroxytryptamine (purchased fr...


US Patent US9550741 (2017)

More data for this
Ligand-Target Pair
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