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Found 4017 hits Enz. Inhib. hit(s) with Target = 'Acetyl-CoA carboxylase 2'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM47172
PNG
(US8962641, 8.1 | US8962641, 8.65)
Show SMILES C[C@H](NC(C)=O)c1ccc(O[C@@H]2CCN(C2)c2nc(ncc2F)N(C)C)cc1
Show InChI InChI=1S/C20H26FN5O2/c1-13(23-14(2)27)15-5-7-16(8-6-15)28-17-9-10-26(12-17)19-18(21)11-22-20(24-19)25(3)4/h5-8,11,13,17H,9-10,12H2,1-4H3,(H,23,27)/t13-,17+/m0/s1
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n/an/a 80n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Malonyl CoA formation by acetyl CoA carboxylases is stoichometrically linked to the consumption of ATP. ACC2 activity is measured in a NADH-linked ki...


US Patent US8962641 (2015)


BindingDB Entry DOI: 10.7270/Q2H130Q5
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM50332552
PNG
(CHEMBL1630708 | N-(4-(4-(5-(cyclopentyloxy)pyridin...)
Show SMILES CC(CCc1ccc(Oc2ccc(OC3CCCC3)cn2)cc1)NC(C)=O
Show InChI InChI=1S/C22H28N2O3/c1-16(24-17(2)25)7-8-18-9-11-20(12-10-18)27-22-14-13-21(15-23-22)26-19-5-3-4-6-19/h9-16,19H,3-8H2,1-2H3,(H,24,25)
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n/an/a 140n/an/an/an/a7.537



Sanofi

US Patent


Assay Description
the enzymatic activity of ACC and its inhibition by test substances were determined by a luminometric assay.


US Patent US8470841 (2013)


BindingDB Entry DOI: 10.7270/Q2183537
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM50332556
PNG
(CHEMBL1630704 | US8470841, 4 | trans-N-(3-(5-(4-(b...)
Show SMILES CC(=O)NCCC[C@H]1OC[C@@H](CO1)Oc1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C22H27NO5/c1-17(24)23-13-5-8-22-26-15-21(16-27-22)28-20-11-9-19(10-12-20)25-14-18-6-3-2-4-7-18/h2-4,6-7,9-12,21-22H,5,8,13-16H2,1H3,(H,23,24)/t21-,22-
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n/an/a 400n/an/an/an/a7.537



Sanofi

US Patent


Assay Description
the enzymatic activity of ACC and its inhibition by test substances were determined by a luminometric assay.


US Patent US8470841 (2013)


BindingDB Entry DOI: 10.7270/Q2183537
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM50332555
PNG
(CHEMBL1630705 | US8470841, 6 | trans-N-(3-(5-(4-(c...)
Show SMILES CC(=O)NCCC[C@H]1OC[C@@H](CO1)Oc1ccc(OC2CCCC2)cc1
Show InChI InChI=1S/C20H29NO5/c1-15(22)21-12-4-7-20-23-13-19(14-24-20)26-18-10-8-17(9-11-18)25-16-5-2-3-6-16/h8-11,16,19-20H,2-7,12-14H2,1H3,(H,21,22)/t19-,20-
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n/an/a 200n/an/an/an/a7.537



Sanofi

US Patent


Assay Description
the enzymatic activity of ACC and its inhibition by test substances were determined by a luminometric assay.


US Patent US8470841 (2013)


BindingDB Entry DOI: 10.7270/Q2183537
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM50332553
PNG
(CHEMBL1630707 | N-(3-(4-(5-(cyclopentyloxy)pyridin...)
Show SMILES CC(=O)NCCCc1ccc(Oc2ccc(OC3CCCC3)cn2)cc1
Show InChI InChI=1S/C21H26N2O3/c1-16(24)22-14-4-5-17-8-10-19(11-9-17)26-21-13-12-20(15-23-21)25-18-6-2-3-7-18/h8-13,15,18H,2-7,14H2,1H3,(H,22,24)
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n/an/a 1.28E+3n/an/an/an/a7.537



Sanofi

US Patent


Assay Description
the enzymatic activity of ACC and its inhibition by test substances were determined by a luminometric assay.


US Patent US8470841 (2013)


BindingDB Entry DOI: 10.7270/Q2183537
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM97597
PNG
(US8470841, 9)
Show SMILES CC(CCc1ccc(Oc2ccc(OCc3ccccc3)cn2)cc1)NC(C)=O
Show InChI InChI=1S/C24H26N2O3/c1-18(26-19(2)27)8-9-20-10-12-22(13-11-20)29-24-15-14-23(16-25-24)28-17-21-6-4-3-5-7-21/h3-7,10-16,18H,8-9,17H2,1-2H3,(H,26,27)
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US Patent


Assay Description
the enzymatic activity of ACC and its inhibition by test substances were determined by a luminometric assay.


US Patent US8470841 (2013)


BindingDB Entry DOI: 10.7270/Q2183537
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM97598
PNG
(US8470841, 10)
Show SMILES CC(C)Oc1ccc(Oc2ccc(CCC(C)NC(C)=O)cc2)nc1
Show InChI InChI=1S/C20H26N2O3/c1-14(2)24-19-11-12-20(21-13-19)25-18-9-7-17(8-10-18)6-5-15(3)22-16(4)23/h7-15H,5-6H2,1-4H3,(H,22,23)
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US Patent


Assay Description
the enzymatic activity of ACC and its inhibition by test substances were determined by a luminometric assay.


US Patent US8470841 (2013)


BindingDB Entry DOI: 10.7270/Q2183537
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM97599
PNG
(US8470841, 11)
Show SMILES CCCOc1ccc(Oc2ccc(CCC(C)NC(C)=O)cc2)nc1
Show InChI InChI=1S/C20H26N2O3/c1-4-13-24-19-11-12-20(21-14-19)25-18-9-7-17(8-10-18)6-5-15(2)22-16(3)23/h7-12,14-15H,4-6,13H2,1-3H3,(H,22,23)
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US Patent


Assay Description
the enzymatic activity of ACC and its inhibition by test substances were determined by a luminometric assay.


US Patent US8470841 (2013)


BindingDB Entry DOI: 10.7270/Q2183537
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM97600
PNG
(US8470841, 12)
Show SMILES CC(CCc1ccc(Oc2ccc(OCC3CCC3)cn2)cc1)NC(C)=O
Show InChI InChI=1S/C22H28N2O3/c1-16(24-17(2)25)6-7-18-8-10-20(11-9-18)27-22-13-12-21(14-23-22)26-15-19-4-3-5-19/h8-14,16,19H,3-7,15H2,1-2H3,(H,24,25)
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US Patent


Assay Description
the enzymatic activity of ACC and its inhibition by test substances were determined by a luminometric assay.


US Patent US8470841 (2013)


BindingDB Entry DOI: 10.7270/Q2183537
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM97601
PNG
(US8470841, 17)
Show SMILES CC(=O)NCCC[C@H]1OC[C@@H](CO1)Oc1ccc(OCc2ccccc2)cn1
Show InChI InChI=1S/C21H26N2O5/c1-16(24)22-11-5-8-21-26-14-19(15-27-21)28-20-10-9-18(12-23-20)25-13-17-6-3-2-4-7-17/h2-4,6-7,9-10,12,19,21H,5,8,11,13-15H2,1H3,(H,22,24)/t19-,21-
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US Patent


Assay Description
the enzymatic activity of ACC and its inhibition by test substances were determined by a luminometric assay.


US Patent US8470841 (2013)


BindingDB Entry DOI: 10.7270/Q2183537
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM64583
PNG
(BDBM50332551 | US8470841, 19)
Show SMILES C[C@@H](CCc1ccc(Oc2ccc(OCc3ccccc3)cn2)cc1)NC(C)=O
Show InChI InChI=1S/C24H26N2O3/c1-18(26-19(2)27)8-9-20-10-12-22(13-11-20)29-24-15-14-23(16-25-24)28-17-21-6-4-3-5-7-21/h3-7,10-16,18H,8-9,17H2,1-2H3,(H,26,27)/t18-/m0/s1
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US Patent


Assay Description
the enzymatic activity of ACC and its inhibition by test substances were determined by a luminometric assay.


US Patent US8470841 (2013)


BindingDB Entry DOI: 10.7270/Q2183537
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM97603
PNG
(US8470841, 20)
Show SMILES CC(CCc1ccc(Oc2ccc(OC3CCOC3)cn2)cc1)NC(C)=O
Show InChI InChI=1S/C21H26N2O4/c1-15(23-16(2)24)3-4-17-5-7-18(8-6-17)27-21-10-9-19(13-22-21)26-20-11-12-25-14-20/h5-10,13,15,20H,3-4,11-12,14H2,1-2H3,(H,23,24)
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n/an/a 3.60E+3n/an/an/an/a7.537



Sanofi

US Patent


Assay Description
the enzymatic activity of ACC and its inhibition by test substances were determined by a luminometric assay.


US Patent US8470841 (2013)


BindingDB Entry DOI: 10.7270/Q2183537
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM97604
PNG
(US8470841, 23)
Show SMILES CC(C)Oc1ccc(O[C@H]2CO[C@H](CCCNC(C)=O)OC2)nc1
Show InChI InChI=1S/C17H26N2O5/c1-12(2)23-14-6-7-16(19-9-14)24-15-10-21-17(22-11-15)5-4-8-18-13(3)20/h6-7,9,12,15,17H,4-5,8,10-11H2,1-3H3,(H,18,20)/t15-,17-
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n/an/a 2.00E+3n/an/an/an/a7.537



Sanofi

US Patent


Assay Description
the enzymatic activity of ACC and its inhibition by test substances were determined by a luminometric assay.


US Patent US8470841 (2013)


BindingDB Entry DOI: 10.7270/Q2183537
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM97605
PNG
(US8470841, 25)
Show SMILES CC(C)Oc1cnc(O[C@H]2CO[C@H](CCCNC(C)=O)OC2)c(Cl)c1
Show InChI InChI=1S/C17H25ClN2O5/c1-11(2)24-13-7-15(18)17(20-8-13)25-14-9-22-16(23-10-14)5-4-6-19-12(3)21/h7-8,11,14,16H,4-6,9-10H2,1-3H3,(H,19,21)/t14-,16-
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US Patent


Assay Description
the enzymatic activity of ACC and its inhibition by test substances were determined by a luminometric assay.


US Patent US8470841 (2013)


BindingDB Entry DOI: 10.7270/Q2183537
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM97606
PNG
(US8470841, 27)
Show SMILES CC(C)Oc1ccc(Oc2ccc(OCC(C)NC(C)=O)cc2)nc1
Show InChI InChI=1S/C19H24N2O4/c1-13(2)24-18-9-10-19(20-11-18)25-17-7-5-16(6-8-17)23-12-14(3)21-15(4)22/h5-11,13-14H,12H2,1-4H3,(H,21,22)
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n/an/a 1.30E+3n/an/an/an/a7.537



Sanofi

US Patent


Assay Description
the enzymatic activity of ACC and its inhibition by test substances were determined by a luminometric assay.


US Patent US8470841 (2013)


BindingDB Entry DOI: 10.7270/Q2183537
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM97607
PNG
(US8470841, 29)
Show SMILES CC(C)Oc1ccc(Oc2ccc(OC[C@H](C)NC(C)=O)cc2)nc1
Show InChI InChI=1S/C19H24N2O4/c1-13(2)24-18-9-10-19(20-11-18)25-17-7-5-16(6-8-17)23-12-14(3)21-15(4)22/h5-11,13-14H,12H2,1-4H3,(H,21,22)/t14-/m0/s1
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n/an/a 1.20E+3n/an/an/an/a7.537



Sanofi

US Patent


Assay Description
the enzymatic activity of ACC and its inhibition by test substances were determined by a luminometric assay.


US Patent US8470841 (2013)


BindingDB Entry DOI: 10.7270/Q2183537
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM50332549
PNG
((S)-N-(4-(4-(5-isopropoxypyridin-2-yloxy)phenyl)bu...)
Show SMILES CC(C)Oc1ccc(Oc2ccc(CC[C@H](C)NC(C)=O)cc2)nc1
Show InChI InChI=1S/C20H26N2O3/c1-14(2)24-19-11-12-20(21-13-19)25-18-9-7-17(8-10-18)6-5-15(3)22-16(4)23/h7-15H,5-6H2,1-4H3,(H,22,23)/t15-/m0/s1
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US Patent


Assay Description
the enzymatic activity of ACC and its inhibition by test substances were determined by a luminometric assay.


US Patent US8470841 (2013)


BindingDB Entry DOI: 10.7270/Q2183537
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM97608
PNG
(US8470841, 32)
Show SMILES CC(C)Oc1cnc(Oc2ccc(CCC(C)NC(C)=O)cc2)c(Cl)c1
Show InChI InChI=1S/C20H25ClN2O3/c1-13(2)25-18-11-19(21)20(22-12-18)26-17-9-7-16(8-10-17)6-5-14(3)23-15(4)24/h7-14H,5-6H2,1-4H3,(H,23,24)
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US Patent


Assay Description
the enzymatic activity of ACC and its inhibition by test substances were determined by a luminometric assay.


US Patent US8470841 (2013)


BindingDB Entry DOI: 10.7270/Q2183537
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM97609
PNG
(US8470841, 33)
Show SMILES CC(C)Oc1ccc(Oc2ccc(CCC(C)NC(C)=O)cc2)cn1
Show InChI InChI=1S/C20H26N2O3/c1-14(2)24-20-12-11-19(13-21-20)25-18-9-7-17(8-10-18)6-5-15(3)22-16(4)23/h7-15H,5-6H2,1-4H3,(H,22,23)
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US Patent


Assay Description
the enzymatic activity of ACC and its inhibition by test substances were determined by a luminometric assay.


US Patent US8470841 (2013)


BindingDB Entry DOI: 10.7270/Q2183537
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM97610
PNG
(CHEMBL1630715 | US8470841, 35)
Show SMILES CC(C)Oc1ccc(Oc2ccc(CC[C@H](C)NC(C)=O)cc2)cn1
Show InChI InChI=1S/C20H26N2O3/c1-14(2)24-20-12-11-19(13-21-20)25-18-9-7-17(8-10-18)6-5-15(3)22-16(4)23/h7-15H,5-6H2,1-4H3,(H,22,23)/t15-/m0/s1
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US Patent


Assay Description
the enzymatic activity of ACC and its inhibition by test substances were determined by a luminometric assay.


US Patent US8470841 (2013)


BindingDB Entry DOI: 10.7270/Q2183537
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM97611
PNG
(CHEMBL1630712 | US8470841, 36)
Show SMILES CC(CCc1ccc(Oc2ccc(OCc3ccccc3)nc2)cc1)NC(C)=O
Show InChI InChI=1S/C24H26N2O3/c1-18(26-19(2)27)8-9-20-10-12-22(13-11-20)29-23-14-15-24(25-16-23)28-17-21-6-4-3-5-7-21/h3-7,10-16,18H,8-9,17H2,1-2H3,(H,26,27)
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n/an/a 70n/an/an/an/a7.537



Sanofi

US Patent


Assay Description
the enzymatic activity of ACC and its inhibition by test substances were determined by a luminometric assay.


US Patent US8470841 (2013)


BindingDB Entry DOI: 10.7270/Q2183537
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM97612
PNG
(US8470841, 37)
Show SMILES CC(CCc1cnc(Oc2ccc(OCc3ccccc3)nc2)nc1)NC(C)=O
Show InChI InChI=1S/C22H24N4O3/c1-16(26-17(2)27)8-9-19-12-24-22(25-13-19)29-20-10-11-21(23-14-20)28-15-18-6-4-3-5-7-18/h3-7,10-14,16H,8-9,15H2,1-2H3,(H,26,27)
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Sanofi

US Patent


Assay Description
the enzymatic activity of ACC and its inhibition by test substances were determined by a luminometric assay.


US Patent US8470841 (2013)


BindingDB Entry DOI: 10.7270/Q2183537
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM97613
PNG
(US8470841, 39)
Show SMILES CC(C)Oc1ccc(Oc2ccc(OC[C@H](C)NC(C)=O)cn2)cc1
Show InChI InChI=1S/C19H24N2O4/c1-13(2)24-16-5-7-17(8-6-16)25-19-10-9-18(11-20-19)23-12-14(3)21-15(4)22/h5-11,13-14H,12H2,1-4H3,(H,21,22)/t14-/m0/s1
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n/an/a 2.50E+3n/an/an/an/a7.537



Sanofi

US Patent


Assay Description
the enzymatic activity of ACC and its inhibition by test substances were determined by a luminometric assay.


US Patent US8470841 (2013)


BindingDB Entry DOI: 10.7270/Q2183537
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM97614
PNG
(CHEMBL1630717 | US8470841, 40)
Show SMILES CC(C)Oc1ncc(Oc2ccc(CCC(C)NC(C)=O)cc2)cn1
Show InChI InChI=1S/C19H25N3O3/c1-13(2)24-19-20-11-18(12-21-19)25-17-9-7-16(8-10-17)6-5-14(3)22-15(4)23/h7-14H,5-6H2,1-4H3,(H,22,23)
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n/an/a 740n/an/an/an/a7.537



Sanofi

US Patent


Assay Description
the enzymatic activity of ACC and its inhibition by test substances were determined by a luminometric assay.


US Patent US8470841 (2013)


BindingDB Entry DOI: 10.7270/Q2183537
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM97615
PNG
(US8470841, 44)
Show SMILES CC(C)Oc1ccc(Oc2ccc(CCC(C)NC(=O)C3CC3)cc2)cn1
Show InChI InChI=1S/C22H28N2O3/c1-15(2)26-21-13-12-20(14-23-21)27-19-10-6-17(7-11-19)5-4-16(3)24-22(25)18-8-9-18/h6-7,10-16,18H,4-5,8-9H2,1-3H3,(H,24,25)
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n/an/a 90n/an/an/an/a7.537



Sanofi

US Patent


Assay Description
the enzymatic activity of ACC and its inhibition by test substances were determined by a luminometric assay.


US Patent US8470841 (2013)


BindingDB Entry DOI: 10.7270/Q2183537
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM97616
PNG
(CHEMBL1630720 | US8470841, 45)
Show SMILES CC(C)Oc1ccc(Oc2ccc(CCC(C)NC=O)cc2)cn1
Show InChI InChI=1S/C19H24N2O3/c1-14(2)23-19-11-10-18(12-20-19)24-17-8-6-16(7-9-17)5-4-15(3)21-13-22/h6-15H,4-5H2,1-3H3,(H,21,22)
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n/an/a 670n/an/an/an/a7.537



Sanofi

US Patent


Assay Description
the enzymatic activity of ACC and its inhibition by test substances were determined by a luminometric assay.


US Patent US8470841 (2013)


BindingDB Entry DOI: 10.7270/Q2183537
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM97617
PNG
(CHEMBL1629723 | US8470841, 46)
Show SMILES COC(=O)NC(C)CCc1ccc(Oc2ccc(OC(C)C)nc2)cc1
Show InChI InChI=1S/C20H26N2O4/c1-14(2)25-19-12-11-18(13-21-19)26-17-9-7-16(8-10-17)6-5-15(3)22-20(23)24-4/h7-15H,5-6H2,1-4H3,(H,22,23)
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n/an/a 210n/an/an/an/a7.537



Sanofi

US Patent


Assay Description
the enzymatic activity of ACC and its inhibition by test substances were determined by a luminometric assay.


US Patent US8470841 (2013)


BindingDB Entry DOI: 10.7270/Q2183537
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM97618
PNG
(CHEMBL1630702 | US8470841, 47)
Show SMILES CC(C)Oc1ccc(Oc2ccc(CCC(C)NC(N)=O)cc2)cn1
Show InChI InChI=1S/C19H25N3O3/c1-13(2)24-18-11-10-17(12-21-18)25-16-8-6-15(7-9-16)5-4-14(3)22-19(20)23/h6-14H,4-5H2,1-3H3,(H3,20,22,23)
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n/an/a 150n/an/an/an/a7.537



Sanofi

US Patent


Assay Description
the enzymatic activity of ACC and its inhibition by test substances were determined by a luminometric assay.


US Patent US8470841 (2013)


BindingDB Entry DOI: 10.7270/Q2183537
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM97619
PNG
(US8470841, 48)
Show SMILES CC(C)Oc1ccc(Oc2ccc(CCC(C)NC(=O)CO)cc2)cn1
Show InChI InChI=1S/C20H26N2O4/c1-14(2)25-20-11-10-18(12-21-20)26-17-8-6-16(7-9-17)5-4-15(3)22-19(24)13-23/h6-12,14-15,23H,4-5,13H2,1-3H3,(H,22,24)
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Sanofi

US Patent


Assay Description
the enzymatic activity of ACC and its inhibition by test substances were determined by a luminometric assay.


US Patent US8470841 (2013)


BindingDB Entry DOI: 10.7270/Q2183537
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM97621
PNG
(US8470841, 50)
Show SMILES CC(CCc1ccc(Oc2ccc(OCC3CC3)nc2)cc1)NC(C)=O
Show InChI InChI=1S/C21H26N2O3/c1-15(23-16(2)24)3-4-17-7-9-19(10-8-17)26-20-11-12-21(22-13-20)25-14-18-5-6-18/h7-13,15,18H,3-6,14H2,1-2H3,(H,23,24)
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Sanofi

US Patent


Assay Description
the enzymatic activity of ACC and its inhibition by test substances were determined by a luminometric assay.


US Patent US8470841 (2013)


BindingDB Entry DOI: 10.7270/Q2183537
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM97622
PNG
(CHEMBL1630701 | US8470841, 51)
Show SMILES CC(C)Oc1ccc(Oc2ccc(CC[C@H](C)NC(=O)C3CC3)cc2)cn1
Show InChI InChI=1S/C22H28N2O3/c1-15(2)26-21-13-12-20(14-23-21)27-19-10-6-17(7-11-19)5-4-16(3)24-22(25)18-8-9-18/h6-7,10-16,18H,4-5,8-9H2,1-3H3,(H,24,25)/t16-/m0/s1
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n/an/a 80n/an/an/an/a7.537



Sanofi

US Patent


Assay Description
the enzymatic activity of ACC and its inhibition by test substances were determined by a luminometric assay.


US Patent US8470841 (2013)


BindingDB Entry DOI: 10.7270/Q2183537
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM97623
PNG
(US8470841, 52)
Show SMILES CC(C)Oc1ccc(OC2CCC(CCC(C)NC(C)=O)CC2)cn1
Show InChI InChI=1S/C20H32N2O3/c1-14(2)24-20-12-11-19(13-21-20)25-18-9-7-17(8-10-18)6-5-15(3)22-16(4)23/h11-15,17-18H,5-10H2,1-4H3,(H,22,23)
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n/an/a 80n/an/an/an/a7.537



Sanofi

US Patent


Assay Description
the enzymatic activity of ACC and its inhibition by test substances were determined by a luminometric assay.


US Patent US8470841 (2013)


BindingDB Entry DOI: 10.7270/Q2183537
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM97624
PNG
(US8470841, 59)
Show SMILES CC(C)Oc1ccc(Oc2ccc(OC[C@H](C)NC(C)=O)cc2)cc1
Show InChI InChI=1S/C20H25NO4/c1-14(2)24-18-9-11-20(12-10-18)25-19-7-5-17(6-8-19)23-13-15(3)21-16(4)22/h5-12,14-15H,13H2,1-4H3,(H,21,22)/t15-/m0/s1
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n/an/a 120n/an/an/an/a7.537



Sanofi

US Patent


Assay Description
the enzymatic activity of ACC and its inhibition by test substances were determined by a luminometric assay.


US Patent US8470841 (2013)


BindingDB Entry DOI: 10.7270/Q2183537
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM97620
PNG
(US8470841, 49)
Show SMILES CC(C)Oc1cnc(Oc2ccc(CCC(C)NC(C)=O)cc2)cn1
Show InChI InChI=1S/C19H25N3O3/c1-13(2)24-18-11-21-19(12-20-18)25-17-9-7-16(8-10-17)6-5-14(3)22-15(4)23/h7-14H,5-6H2,1-4H3,(H,22,23)
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n/an/a 1.20E+3n/an/an/an/a7.537



Sanofi

US Patent


Assay Description
the enzymatic activity of ACC and its inhibition by test substances were determined by a luminometric assay.


US Patent US8470841 (2013)


BindingDB Entry DOI: 10.7270/Q2183537
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM131546
PNG
(US8835472, 13.50)
Show SMILES CCC(C)Nc1ncc(cn1)C#Cc1ccc(CC(C)NC(=O)C2CC2)cc1
Show InChI InChI=1S/C23H28N4O/c1-4-16(2)27-23-24-14-20(15-25-23)10-7-18-5-8-19(9-6-18)13-17(3)26-22(28)21-11-12-21/h5-6,8-9,14-17,21H,4,11-13H2,1-3H3,(H,26,28)(H,24,25,27)
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n/an/a 1.50E+3n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Malonyl CoA formation by acetyl CoA carboxylases is stoichometrically linked to the consumption of ATP. ACC2 activity is measured in a NADH-linked ki...


US Patent US8835472 (2014)


BindingDB Entry DOI: 10.7270/Q25T3J6W
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM131547
PNG
(US8835472, 13.51)
Show SMILES CC(Cc1ccc(cc1)C#Cc1cnc(nc1)N1CCC1)NC(=O)C1CC1
Show InChI InChI=1S/C22H24N4O/c1-16(25-21(27)20-9-10-20)13-18-6-3-17(4-7-18)5-8-19-14-23-22(24-15-19)26-11-2-12-26/h3-4,6-7,14-16,20H,2,9-13H2,1H3,(H,25,27)
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n/an/a 2.20E+3n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Malonyl CoA formation by acetyl CoA carboxylases is stoichometrically linked to the consumption of ATP. ACC2 activity is measured in a NADH-linked ki...


US Patent US8835472 (2014)


BindingDB Entry DOI: 10.7270/Q25T3J6W
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM131548
PNG
(US8835472, 13.52)
Show SMILES CCNc1ncc(cn1)C#Cc1ccc(CC(C)NC(=O)C2CC2)cc1
Show InChI InChI=1S/C21H24N4O/c1-3-22-21-23-13-18(14-24-21)9-6-16-4-7-17(8-5-16)12-15(2)25-20(26)19-10-11-19/h4-5,7-8,13-15,19H,3,10-12H2,1-2H3,(H,25,26)(H,22,23,24)
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n/an/a 5.20E+3n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Malonyl CoA formation by acetyl CoA carboxylases is stoichometrically linked to the consumption of ATP. ACC2 activity is measured in a NADH-linked ki...


US Patent US8835472 (2014)


BindingDB Entry DOI: 10.7270/Q25T3J6W
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM131549
PNG
(US8835472, 13.53)
Show SMILES CC(Cc1ccc(cc1)C#Cc1cnc(NCCF)nc1)NC(=O)C1CC1
Show InChI InChI=1S/C21H23FN4O/c1-15(26-20(27)19-8-9-19)12-17-5-2-16(3-6-17)4-7-18-13-24-21(25-14-18)23-11-10-22/h2-3,5-6,13-15,19H,8-12H2,1H3,(H,26,27)(H,23,24,25)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Malonyl CoA formation by acetyl CoA carboxylases is stoichometrically linked to the consumption of ATP. ACC2 activity is measured in a NADH-linked ki...


US Patent US8835472 (2014)


BindingDB Entry DOI: 10.7270/Q25T3J6W
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM131550
PNG
(US8835472, 13.54)
Show SMILES CC(Cc1ccc(cc1)C#Cc1cnc(NCc2ccccc2)nc1)NC(=O)C1CC1
Show InChI InChI=1S/C26H26N4O/c1-19(30-25(31)24-13-14-24)15-21-10-7-20(8-11-21)9-12-23-17-28-26(29-18-23)27-16-22-5-3-2-4-6-22/h2-8,10-11,17-19,24H,13-16H2,1H3,(H,30,31)(H,27,28,29)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Malonyl CoA formation by acetyl CoA carboxylases is stoichometrically linked to the consumption of ATP. ACC2 activity is measured in a NADH-linked ki...


US Patent US8835472 (2014)


BindingDB Entry DOI: 10.7270/Q25T3J6W
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM131551
PNG
(US8835472, 13.55)
Show SMILES CC(Cc1ccc(cc1)C#Cc1cnc(NCc2ccccc2C)nc1)NC(C)=O
Show InChI InChI=1S/C25H26N4O/c1-18-6-4-5-7-24(18)17-28-25-26-15-23(16-27-25)13-10-21-8-11-22(12-9-21)14-19(2)29-20(3)30/h4-9,11-12,15-16,19H,14,17H2,1-3H3,(H,29,30)(H,26,27,28)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Malonyl CoA formation by acetyl CoA carboxylases is stoichometrically linked to the consumption of ATP. ACC2 activity is measured in a NADH-linked ki...


US Patent US8835472 (2014)


BindingDB Entry DOI: 10.7270/Q25T3J6W
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM131552
PNG
(US8835472, 13.56)
Show SMILES CC(Cc1ccc(cc1)C#Cc1cnc(NCc2cccc(C)c2)nc1)NC(C)=O
Show InChI InChI=1S/C25H26N4O/c1-18-5-4-6-23(13-18)15-26-25-27-16-24(17-28-25)12-9-21-7-10-22(11-8-21)14-19(2)29-20(3)30/h4-8,10-11,13,16-17,19H,14-15H2,1-3H3,(H,29,30)(H,26,27,28)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Malonyl CoA formation by acetyl CoA carboxylases is stoichometrically linked to the consumption of ATP. ACC2 activity is measured in a NADH-linked ki...


US Patent US8835472 (2014)


BindingDB Entry DOI: 10.7270/Q25T3J6W
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM131553
PNG
(US8835472, 13.57)
Show SMILES CC(Cc1ccc(cc1)C#Cc1cnc(nc1)N1CCC(C)(C)CC1)NC(C)=O
Show InChI InChI=1S/C24H30N4O/c1-18(27-19(2)29)15-21-8-5-20(6-9-21)7-10-22-16-25-23(26-17-22)28-13-11-24(3,4)12-14-28/h5-6,8-9,16-18H,11-15H2,1-4H3,(H,27,29)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Malonyl CoA formation by acetyl CoA carboxylases is stoichometrically linked to the consumption of ATP. ACC2 activity is measured in a NADH-linked ki...


US Patent US8835472 (2014)


BindingDB Entry DOI: 10.7270/Q25T3J6W
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM131554
PNG
(US8835472, 13.58)
Show SMILES CC(Cc1ccc(cc1)C#Cc1cnc(nc1)N(C)C)NC(C)=O
Show InChI InChI=1S/C19H22N4O/c1-14(22-15(2)24)11-17-8-5-16(6-9-17)7-10-18-12-20-19(21-13-18)23(3)4/h5-6,8-9,12-14H,11H2,1-4H3,(H,22,24)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Malonyl CoA formation by acetyl CoA carboxylases is stoichometrically linked to the consumption of ATP. ACC2 activity is measured in a NADH-linked ki...


US Patent US8835472 (2014)


BindingDB Entry DOI: 10.7270/Q25T3J6W
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM131555
PNG
(US8835472, 13.59)
Show SMILES CC(Cc1ccc(cc1)C#Cc1cnc(NCC(F)(F)F)nc1)NC(C)=O
Show InChI InChI=1S/C19H19F3N4O/c1-13(26-14(2)27)9-16-6-3-15(4-7-16)5-8-17-10-23-18(24-11-17)25-12-19(20,21)22/h3-4,6-7,10-11,13H,9,12H2,1-2H3,(H,26,27)(H,23,24,25)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Malonyl CoA formation by acetyl CoA carboxylases is stoichometrically linked to the consumption of ATP. ACC2 activity is measured in a NADH-linked ki...


US Patent US8835472 (2014)


BindingDB Entry DOI: 10.7270/Q25T3J6W
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM131556
PNG
(US8835472, 13.60)
Show SMILES CNc1ncc(cn1)C#Cc1ccc(CC(C)NC(C)=O)cc1
Show InChI InChI=1S/C18H20N4O/c1-13(22-14(2)23)10-16-7-4-15(5-8-16)6-9-17-11-20-18(19-3)21-12-17/h4-5,7-8,11-13H,10H2,1-3H3,(H,22,23)(H,19,20,21)
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n/an/a 250n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Malonyl CoA formation by acetyl CoA carboxylases is stoichometrically linked to the consumption of ATP. ACC2 activity is measured in a NADH-linked ki...


US Patent US8835472 (2014)


BindingDB Entry DOI: 10.7270/Q25T3J6W
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM131557
PNG
(US8835472, 13.61)
Show SMILES CC(Cc1ccc(cc1)C#Cc1cnc(NCc2cnn(C)c2)nc1)NC(C)=O
Show InChI InChI=1S/C22H24N6O/c1-16(27-17(2)29)10-19-7-4-18(5-8-19)6-9-20-11-23-22(24-12-20)25-13-21-14-26-28(3)15-21/h4-5,7-8,11-12,14-16H,10,13H2,1-3H3,(H,27,29)(H,23,24,25)
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n/an/a 3.80E+3n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Malonyl CoA formation by acetyl CoA carboxylases is stoichometrically linked to the consumption of ATP. ACC2 activity is measured in a NADH-linked ki...


US Patent US8835472 (2014)


BindingDB Entry DOI: 10.7270/Q25T3J6W
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM131558
PNG
(US8835472, 13.62)
Show SMILES CC(Cc1ccc(cc1)C#Cc1cnc(N[C@H]2CCc3ccccc23)nc1)NC(C)=O
Show InChI InChI=1S/C26H26N4O/c1-18(29-19(2)31)15-21-10-7-20(8-11-21)9-12-22-16-27-26(28-17-22)30-25-14-13-23-5-3-4-6-24(23)25/h3-8,10-11,16-18,25H,13-15H2,1-2H3,(H,29,31)(H,27,28,30)/t18?,25-/m0/s1
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n/an/a 330n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Malonyl CoA formation by acetyl CoA carboxylases is stoichometrically linked to the consumption of ATP. ACC2 activity is measured in a NADH-linked ki...


US Patent US8835472 (2014)


BindingDB Entry DOI: 10.7270/Q25T3J6W
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM131559
PNG
(US8835472, 13.63)
Show SMILES CC(Cc1ccc(cc1)C#Cc1cnc(N[C@@H]2CCc3ccccc23)nc1)NC(C)=O
Show InChI InChI=1S/C26H26N4O/c1-18(29-19(2)31)15-21-10-7-20(8-11-21)9-12-22-16-27-26(28-17-22)30-25-14-13-23-5-3-4-6-24(23)25/h3-8,10-11,16-18,25H,13-15H2,1-2H3,(H,29,31)(H,27,28,30)/t18?,25-/m1/s1
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n/an/a 200n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Malonyl CoA formation by acetyl CoA carboxylases is stoichometrically linked to the consumption of ATP. ACC2 activity is measured in a NADH-linked ki...


US Patent US8835472 (2014)


BindingDB Entry DOI: 10.7270/Q25T3J6W
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM131560
PNG
(US8835472, 13.64)
Show SMILES CC(Cc1ccc(cc1)C#Cc1cnc(nc1)N1Cc2ccccc2C1)NC(C)=O
Show InChI InChI=1S/C25H24N4O/c1-18(28-19(2)30)13-21-10-7-20(8-11-21)9-12-22-14-26-25(27-15-22)29-16-23-5-3-4-6-24(23)17-29/h3-8,10-11,14-15,18H,13,16-17H2,1-2H3,(H,28,30)
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n/an/a 800n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Malonyl CoA formation by acetyl CoA carboxylases is stoichometrically linked to the consumption of ATP. ACC2 activity is measured in a NADH-linked ki...


US Patent US8835472 (2014)


BindingDB Entry DOI: 10.7270/Q25T3J6W
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM131561
PNG
(US8835472, 13.65)
Show SMILES CC(Cc1ccc(cc1)C#Cc1cnc(NCCF)nc1)NC(C)=O
Show InChI InChI=1S/C19H21FN4O/c1-14(24-15(2)25)11-17-6-3-16(4-7-17)5-8-18-12-22-19(23-13-18)21-10-9-20/h3-4,6-7,12-14H,9-11H2,1-2H3,(H,24,25)(H,21,22,23)
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n/an/a 1.60E+3n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Malonyl CoA formation by acetyl CoA carboxylases is stoichometrically linked to the consumption of ATP. ACC2 activity is measured in a NADH-linked ki...


US Patent US8835472 (2014)


BindingDB Entry DOI: 10.7270/Q25T3J6W
More data for this
Ligand-Target Pair
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