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Found 151 hits Enz. Inhib. hit(s) with Target = 'Acetyl-coenzyme A transporter 1 (AT1)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107318
PNG
(US8592431, 2)
Show SMILES CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n(CC(C)(C)C)c2nc(C)nn12
Show InChI InChI=1S/C29H32N6O3/c1-6-9-24-23(26(36)34(17-29(3,4)5)27-30-18(2)32-35(24)27)16-19-12-14-20(15-13-19)21-10-7-8-11-22(21)25-31-28(37)38-33-25/h7-8,10-15H,6,9,16-17H2,1-5H3,(H,31,33,37)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107319
PNG
(US8592431, 4)
Show SMILES CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n(Cc2ccc(F)cc2)c2ncnn12
Show InChI InChI=1S/C30H25FN6O3/c1-2-5-26-25(28(38)36(29-32-18-33-37(26)29)17-20-10-14-22(31)15-11-20)16-19-8-12-21(13-9-19)23-6-3-4-7-24(23)27-34-30(39)40-35-27/h3-4,6-15,18H,2,5,16-17H2,1H3,(H,34,35,39)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107320
PNG
(US8592431, 5)
Show SMILES CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n(Cc2ccc(F)cc2)c2nc(C)nn12
Show InChI InChI=1S/C31H27FN6O3/c1-3-6-27-26(29(39)37(30-33-19(2)35-38(27)30)18-21-11-15-23(32)16-12-21)17-20-9-13-22(14-10-20)24-7-4-5-8-25(24)28-34-31(40)41-36-28/h4-5,7-16H,3,6,17-18H2,1-2H3,(H,34,36,40)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107321
PNG
(US8592431, 7)
Show SMILES CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n(Cc2ccc(CC)nc2)c2nc(C)nn12
Show InChI InChI=1S/C32H31N7O3/c1-4-8-28-27(30(40)38(31-34-20(3)36-39(28)31)19-22-13-16-24(5-2)33-18-22)17-21-11-14-23(15-12-21)25-9-6-7-10-26(25)29-35-32(41)42-37-29/h6-7,9-16,18H,4-5,8,17,19H2,1-3H3,(H,35,37,41)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107322
PNG
(US8592431, 9)
Show SMILES CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n(CC(C)(C)C)c2ncnn12
Show InChI InChI=1S/C28H30N6O3/c1-5-8-23-22(25(35)33(16-28(2,3)4)26-29-17-30-34(23)26)15-18-11-13-19(14-12-18)20-9-6-7-10-21(20)24-31-27(36)37-32-24/h6-7,9-14,17H,5,8,15-16H2,1-4H3,(H,31,32,36)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107323
PNG
(US8592431, 10)
Show SMILES CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n(CC(=O)C(C)(C)C)c2ncnn12
Show InChI InChI=1S/C29H30N6O4/c1-5-8-23-22(26(37)34(16-24(36)29(2,3)4)27-30-17-31-35(23)27)15-18-11-13-19(14-12-18)20-9-6-7-10-21(20)25-32-28(38)39-33-25/h6-7,9-14,17H,5,8,15-16H2,1-4H3,(H,32,33,38)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107324
PNG
(US8592431, 21)
Show SMILES CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n(CC2CC2)c2ncnn12
Show InChI InChI=1S/C27H26N6O3/c1-2-5-23-22(25(34)32(15-18-8-9-18)26-28-16-29-33(23)26)14-17-10-12-19(13-11-17)20-6-3-4-7-21(20)24-30-27(35)36-31-24/h3-4,6-7,10-13,16,18H,2,5,8-9,14-15H2,1H3,(H,30,31,35)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107325
PNG
(US8592431, 28)
Show SMILES CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n(Cc2ccc(cc2)C(C)=O)c2ncnn12
Show InChI InChI=1S/C32H28N6O4/c1-3-6-28-27(30(40)37(31-33-19-34-38(28)31)18-22-11-13-23(14-12-22)20(2)39)17-21-9-15-24(16-10-21)25-7-4-5-8-26(25)29-35-32(41)42-36-29/h4-5,7-16,19H,3,6,17-18H2,1-2H3,(H,35,36,41)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107326
PNG
(US8592431, 29)
Show SMILES CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n(CCC)c2ncnn12
Show InChI InChI=1S/C26H26N6O3/c1-3-7-22-21(24(33)31(14-4-2)25-27-16-28-32(22)25)15-17-10-12-18(13-11-17)19-8-5-6-9-20(19)23-29-26(34)35-30-23/h5-6,8-13,16H,3-4,7,14-15H2,1-2H3,(H,29,30,34)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107327
PNG
(US8592431, 37)
Show SMILES CCCc1c(Cc2ccc(cc2F)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n(Cc2ccc(OC)cc2OC)c2ncnn12
Show InChI InChI=1S/C32H29FN6O5/c1-4-7-27-25(30(40)38(31-34-18-35-39(27)31)17-21-12-13-22(42-2)16-28(21)43-3)14-20-11-10-19(15-26(20)33)23-8-5-6-9-24(23)29-36-32(41)44-37-29/h5-6,8-13,15-16,18H,4,7,14,17H2,1-3H3,(H,36,37,41)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107328
PNG
(US8592431, 43)
Show SMILES CCCc1c(Cc2ccc(cc2F)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n(-c2ccc(OC(C)C)cc2)c2ncnn12
Show InChI InChI=1S/C32H29FN6O4/c1-4-7-28-26(30(40)38(31-34-18-35-39(28)31)22-12-14-23(15-13-22)42-19(2)3)16-21-11-10-20(17-27(21)33)24-8-5-6-9-25(24)29-36-32(41)43-37-29/h5-6,8-15,17-19H,4,7,16H2,1-3H3,(H,36,37,41)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107329
PNG
(US8592431, 68)
Show SMILES CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n(C(C)CC)c2nc(C)nn12
Show InChI InChI=1S/C28H30N6O3/c1-5-9-24-23(26(35)33(17(3)6-2)27-29-18(4)31-34(24)27)16-19-12-14-20(15-13-19)21-10-7-8-11-22(21)25-30-28(36)37-32-25/h7-8,10-15,17H,5-6,9,16H2,1-4H3,(H,30,32,36)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107330
PNG
(US8592431, 69)
Show SMILES CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n(CC2(C)CC2)c2nc(C)nn12
Show InChI InChI=1S/C29H30N6O3/c1-4-7-24-23(26(36)34(17-29(3)14-15-29)27-30-18(2)32-35(24)27)16-19-10-12-20(13-11-19)21-8-5-6-9-22(21)25-31-28(37)38-33-25/h5-6,8-13H,4,7,14-17H2,1-3H3,(H,31,33,37)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107331
PNG
(US8592431, 73)
Show SMILES CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n(CC(C)(C)COC)c2nc(C)nn12
Show InChI InChI=1S/C30H34N6O4/c1-6-9-25-24(27(37)35(17-30(3,4)18-39-5)28-31-19(2)33-36(25)28)16-20-12-14-21(15-13-20)22-10-7-8-11-23(22)26-32-29(38)40-34-26/h7-8,10-15H,6,9,16-18H2,1-5H3,(H,32,34,38)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107332
PNG
(US8592431, 74)
Show SMILES CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n(C2CCCC=C2)c2nc(C)nn12
Show InChI InChI=1S/C30H30N6O3/c1-3-9-26-25(28(37)35(22-10-5-4-6-11-22)29-31-19(2)33-36(26)29)18-20-14-16-21(17-15-20)23-12-7-8-13-24(23)27-32-30(38)39-34-27/h5,7-8,10,12-17,22H,3-4,6,9,11,18H2,1-2H3,(H,32,34,38)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107333
PNG
(US8592431, 78)
Show SMILES CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n(C2CCCCC2)c2nc(C)nn12
Show InChI InChI=1S/C30H32N6O3/c1-3-9-26-25(28(37)35(22-10-5-4-6-11-22)29-31-19(2)33-36(26)29)18-20-14-16-21(17-15-20)23-12-7-8-13-24(23)27-32-30(38)39-34-27/h7-8,12-17,22H,3-6,9-11,18H2,1-2H3,(H,32,34,38)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107334
PNG
(US8592431, 83)
Show SMILES CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n(C2CCC2)c2nc(C)nn12
Show InChI InChI=1S/C28H28N6O3/c1-3-7-24-23(26(35)33(20-8-6-9-20)27-29-17(2)31-34(24)27)16-18-12-14-19(15-13-18)21-10-4-5-11-22(21)25-30-28(36)37-32-25/h4-5,10-15,20H,3,6-9,16H2,1-2H3,(H,30,32,36)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107335
PNG
(US8592431, 107)
Show SMILES CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n(C\C(=N/OCC)C(F)(F)F)c2nc(C)nn12
Show InChI InChI=1S/C29H28F3N7O4/c1-4-8-23-22(26(40)38(27-33-17(3)35-39(23)27)16-24(29(30,31)32)36-42-5-2)15-18-11-13-19(14-12-18)20-9-6-7-10-21(20)25-34-28(41)43-37-25/h6-7,9-14H,4-5,8,15-16H2,1-3H3,(H,34,37,41)/b36-24+
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107336
PNG
(US8592431, 108)
Show SMILES CCCc1c(Cc2ccc(cc2F)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n(C2CCOCC2)c2nc(C)nn12
Show InChI InChI=1S/C29H29FN6O4/c1-3-6-25-23(27(37)35(20-11-13-39-14-12-20)28-31-17(2)33-36(25)28)15-19-10-9-18(16-24(19)30)21-7-4-5-8-22(21)26-32-29(38)40-34-26/h4-5,7-10,16,20H,3,6,11-15H2,1-2H3,(H,32,34,38)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107337
PNG
(US8592431, 109)
Show SMILES CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n(C2CCOCC2)c2ncnn12
Show InChI InChI=1S/C28H28N6O4/c1-2-5-24-23(26(35)33(20-12-14-37-15-13-20)27-29-17-30-34(24)27)16-18-8-10-19(11-9-18)21-6-3-4-7-22(21)25-31-28(36)38-32-25/h3-4,6-11,17,20H,2,5,12-16H2,1H3,(H,31,32,36)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107338
PNG
(US8592431, 113)
Show SMILES CCCc1c(Cc2ccc(cc2F)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n(C2CCSCC2)c2nc(C)nn12
Show InChI InChI=1S/C29H29FN6O3S/c1-3-6-25-23(27(37)35(20-11-13-40-14-12-20)28-31-17(2)33-36(25)28)15-19-10-9-18(16-24(19)30)21-7-4-5-8-22(21)26-32-29(38)39-34-26/h4-5,7-10,16,20H,3,6,11-15H2,1-2H3,(H,32,34,38)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107339
PNG
(US8592431, 114)
Show SMILES CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n(C(C)C(\C)=N\OCC)c2nc(C)nn12
Show InChI InChI=1S/C30H33N7O4/c1-6-10-26-25(28(38)36(19(4)18(3)34-40-7-2)29-31-20(5)33-37(26)29)17-21-13-15-22(16-14-21)23-11-8-9-12-24(23)27-32-30(39)41-35-27/h8-9,11-16,19H,6-7,10,17H2,1-5H3,(H,32,35,39)/b34-18+
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107340
PNG
(US8592431, 117)
Show SMILES CCCc1c(Cc2ccc(cc2F)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n(C2CCOCC2)c2ncnn12
Show InChI InChI=1S/C28H27FN6O4/c1-2-5-24-22(26(36)34(19-10-12-38-13-11-19)27-30-16-31-35(24)27)14-18-9-8-17(15-23(18)29)20-6-3-4-7-21(20)25-32-28(37)39-33-25/h3-4,6-9,15-16,19H,2,5,10-14H2,1H3,(H,32,33,37)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107341
PNG
(US8592431, 120)
Show SMILES CCCc1c(Cc2ccc(cc2F)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n(C2CCOC2)c2nc(C)nn12
Show InChI InChI=1S/C28H27FN6O4/c1-3-6-24-22(26(36)34(19-11-12-38-15-19)27-30-16(2)32-35(24)27)13-18-10-9-17(14-23(18)29)20-7-4-5-8-21(20)25-31-28(37)39-33-25/h4-5,7-10,14,19H,3,6,11-13,15H2,1-2H3,(H,31,33,37)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107342
PNG
(US8592431, 125)
Show SMILES CCCc1c(Cc2ccc(cc2F)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n(C2CCCOC2)c2ncnn12
Show InChI InChI=1S/C28H27FN6O4/c1-2-6-24-22(26(36)34(19-7-5-12-38-15-19)27-30-16-31-35(24)27)13-18-11-10-17(14-23(18)29)20-8-3-4-9-21(20)25-32-28(37)39-33-25/h3-4,8-11,14,16,19H,2,5-7,12-13,15H2,1H3,(H,32,33,37)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107343
PNG
(US8592431, 121)
Show SMILES CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n(C2CCCOC2)c2ncnn12
Show InChI InChI=1S/C28H28N6O4/c1-2-6-24-23(26(35)33(20-7-5-14-37-16-20)27-29-17-30-34(24)27)15-18-10-12-19(13-11-18)21-8-3-4-9-22(21)25-31-28(36)38-32-25/h3-4,8-13,17,20H,2,5-7,14-16H2,1H3,(H,31,32,36)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107343
PNG
(US8592431, 121)
Show SMILES CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n(C2CCCOC2)c2ncnn12
Show InChI InChI=1S/C28H28N6O4/c1-2-6-24-23(26(35)33(20-7-5-14-37-16-20)27-29-17-30-34(24)27)15-18-10-12-19(13-11-18)21-8-3-4-9-22(21)25-31-28(36)38-32-25/h3-4,8-13,17,20H,2,5-7,14-16H2,1H3,(H,31,32,36)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107345
PNG
(US8592431, 131)
Show SMILES CCCc1c(C(C)c2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n([C@H]2CC[C@@H](CC2)OCC(C)(C)O)c2ncnn12
Show InChI InChI=1S/C34H40N6O5/c1-5-8-28-29(21(2)22-11-13-23(14-12-22)26-9-6-7-10-27(26)30-37-33(42)45-38-30)31(41)39(32-35-20-36-40(28)32)24-15-17-25(18-16-24)44-19-34(3,4)43/h6-7,9-14,20-21,24-25,43H,5,8,15-19H2,1-4H3,(H,37,38,42)/t21?,24-,25-
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107346
PNG
(US8592431, 134)
Show SMILES CCCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n(C2CCOC(C)(C)C2)c2ncnn12
Show InChI InChI=1S/C31H34N6O4/c1-4-5-10-26-25(28(38)36(29-32-19-33-37(26)29)22-15-16-40-31(2,3)18-22)17-20-11-13-21(14-12-20)23-8-6-7-9-24(23)27-34-30(39)41-35-27/h6-9,11-14,19,22H,4-5,10,15-18H2,1-3H3,(H,34,35,39)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107347
PNG
(US8592431, 135)
Show SMILES CCCCc1c(Cc2ccc(cc2F)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n(C2CCOCC2)c2nc(C)nn12
Show InChI InChI=1S/C30H31FN6O4/c1-3-4-9-26-24(28(38)36(21-12-14-40-15-13-21)29-32-18(2)34-37(26)29)16-20-11-10-19(17-25(20)31)22-7-5-6-8-23(22)27-33-30(39)41-35-27/h5-8,10-11,17,21H,3-4,9,12-16H2,1-2H3,(H,33,35,39)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107348
PNG
(US8592431, 136)
Show SMILES CCCc1c(Cc2ccc(cc2F)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n(C2CCOC(C)(C)C2)c2nc(C)nn12
Show InChI InChI=1S/C31H33FN6O4/c1-5-8-26-24(28(39)37(29-33-18(2)35-38(26)29)21-13-14-41-31(3,4)17-21)15-20-12-11-19(16-25(20)32)22-9-6-7-10-23(22)27-34-30(40)42-36-27/h6-7,9-12,16,21H,5,8,13-15,17H2,1-4H3,(H,34,36,40)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107349
PNG
(US8592431, 137)
Show SMILES CCCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n(C2CCOC(C)(C)C2)c2nc(C)nn12
Show InChI InChI=1S/C32H36N6O4/c1-5-6-11-27-26(29(39)37(30-33-20(2)35-38(27)30)23-16-17-41-32(3,4)19-23)18-21-12-14-22(15-13-21)24-9-7-8-10-25(24)28-34-31(40)42-36-28/h7-10,12-15,23H,5-6,11,16-19H2,1-4H3,(H,34,36,40)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107350
PNG
(US8592431, 138)
Show SMILES CCCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n([C@H]2C[C@H](C)O[C@H](C)C2)c2ncnn12
Show InChI InChI=1S/C31H34N6O4/c1-4-5-10-27-26(29(38)36(30-32-18-33-37(27)30)23-15-19(2)40-20(3)16-23)17-21-11-13-22(14-12-21)24-8-6-7-9-25(24)28-34-31(39)41-35-28/h6-9,11-14,18-20,23H,4-5,10,15-17H2,1-3H3,(H,34,35,39)/t19-,20+,23-
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107351
PNG
(US8592431, 139)
Show SMILES CCCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n([C@@H]2C[C@H](C)O[C@H](C)C2)c2ncnn12
Show InChI InChI=1S/C31H34N6O4/c1-4-5-10-27-26(29(38)36(30-32-18-33-37(27)30)23-15-19(2)40-20(3)16-23)17-21-11-13-22(14-12-21)24-8-6-7-9-25(24)28-34-31(39)41-35-28/h6-9,11-14,18-20,23H,4-5,10,15-17H2,1-3H3,(H,34,35,39)/t19-,20+,23+
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107353
PNG
(US8592431, 144)
Show SMILES CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n(C2CCC(C)OC2)c2nc(C)nn12
Show InChI InChI=1S/C30H32N6O4/c1-4-7-26-25(28(37)35(22-15-10-18(2)39-17-22)29-31-19(3)33-36(26)29)16-20-11-13-21(14-12-20)23-8-5-6-9-24(23)27-32-30(38)40-34-27/h5-6,8-9,11-14,18,22H,4,7,10,15-17H2,1-3H3,(H,32,34,38)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107354
PNG
(US8592431, 147)
Show SMILES CCCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n(C2CCC(O)CC2)c2ncnn12
Show InChI InChI=1S/C30H32N6O4/c1-2-3-8-26-25(28(38)35(29-31-18-32-36(26)29)21-13-15-22(37)16-14-21)17-19-9-11-20(12-10-19)23-6-4-5-7-24(23)27-33-30(39)40-34-27/h4-7,9-12,18,21-22,37H,2-3,8,13-17H2,1H3,(H,33,34,39)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107355
PNG
(US8592431, 148)
Show SMILES CCCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n(C2CCC(CC2)OC)c2ncnn12
Show InChI InChI=1S/C31H34N6O4/c1-3-4-9-27-26(29(38)36(30-32-19-33-37(27)30)22-14-16-23(40-2)17-15-22)18-20-10-12-21(13-11-20)24-7-5-6-8-25(24)28-34-31(39)41-35-28/h5-8,10-13,19,22-23H,3-4,9,14-18H2,1-2H3,(H,34,35,39)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107356
PNG
(US8592431, 150)
Show SMILES CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n([C@H]2CC[C@]3(CCCO3)CC2)c2ncnn12
Show InChI InChI=1S/C32H34N6O4/c1-2-6-27-26(19-21-9-11-22(12-10-21)24-7-3-4-8-25(24)28-35-31(40)42-36-28)29(39)37(30-33-20-34-38(27)30)23-13-16-32(17-14-23)15-5-18-41-32/h3-4,7-12,20,23H,2,5-6,13-19H2,1H3,(H,35,36,40)/t23-,32+
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107357
PNG
(US8592431, 151)
Show SMILES CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n([C@H]2CC[C@@]3(CCCO3)CC2)c2ncnn12
Show InChI InChI=1S/C32H34N6O4/c1-2-6-27-26(19-21-9-11-22(12-10-21)24-7-3-4-8-25(24)28-35-31(40)42-36-28)29(39)37(30-33-20-34-38(27)30)23-13-16-32(17-14-23)15-5-18-41-32/h3-4,7-12,20,23H,2,5-6,13-19H2,1H3,(H,35,36,40)/t23-,32-
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107358
PNG
(US8592431, 152)
Show SMILES CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n(C2CCC(CC2)OC)c2ncnn12
Show InChI InChI=1S/C30H32N6O4/c1-3-6-26-25(28(37)35(29-31-18-32-36(26)29)21-13-15-22(39-2)16-14-21)17-19-9-11-20(12-10-19)23-7-4-5-8-24(23)27-33-30(38)40-34-27/h4-5,7-12,18,21-22H,3,6,13-17H2,1-2H3,(H,33,34,38)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107359
PNG
(US8592431, 153)
Show SMILES CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n(C2CCC(CC2)OCC=C)c2ncnn12
Show InChI InChI=1S/C32H34N6O4/c1-3-7-28-27(30(39)37(31-33-20-34-38(28)31)23-14-16-24(17-15-23)41-18-4-2)19-21-10-12-22(13-11-21)25-8-5-6-9-26(25)29-35-32(40)42-36-29/h4-6,8-13,20,23-24H,2-3,7,14-19H2,1H3,(H,35,36,40)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107360
PNG
(US8592431, 158)
Show SMILES CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n([C@@H]2CC[C@@H](CC2)OCC(C)(C)O)c2ncnn12
Show InChI InChI=1S/C33H38N6O5/c1-4-7-28-27(18-21-10-12-22(13-11-21)25-8-5-6-9-26(25)29-36-32(41)44-37-29)30(40)38(31-34-20-35-39(28)31)23-14-16-24(17-15-23)43-19-33(2,3)42/h5-6,8-13,20,23-24,42H,4,7,14-19H2,1-3H3,(H,36,37,41)/t23-,24+
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107361
PNG
(US8592431, 241 | US8592431, 242)
Show SMILES CCCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n(C2CCOC(C)C2)c2ncnn12
Show InChI InChI=1S/C30H32N6O4/c1-3-4-9-26-25(28(37)35(29-31-18-32-36(26)29)22-14-15-39-19(2)16-22)17-20-10-12-21(13-11-20)23-7-5-6-8-24(23)27-33-30(38)40-34-27/h5-8,10-13,18-19,22H,3-4,9,14-17H2,1-2H3,(H,33,34,38)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107361
PNG
(US8592431, 241 | US8592431, 242)
Show SMILES CCCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n(C2CCOC(C)C2)c2ncnn12
Show InChI InChI=1S/C30H32N6O4/c1-3-4-9-26-25(28(37)35(29-31-18-32-36(26)29)22-14-15-39-19(2)16-22)17-20-10-12-21(13-11-20)23-7-5-6-8-24(23)27-33-30(38)40-34-27/h5-8,10-13,18-19,22H,3-4,9,14-17H2,1-2H3,(H,33,34,38)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107363
PNG
(US8592431, 163)
Show SMILES CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n([C@@H]2CC[C@@H](CC2)OCCO)c2ncnn12
Show InChI InChI=1S/C31H34N6O5/c1-2-5-27-26(29(39)36(30-32-19-33-37(27)30)22-12-14-23(15-13-22)41-17-16-38)18-20-8-10-21(11-9-20)24-6-3-4-7-25(24)28-34-31(40)42-35-28/h3-4,6-11,19,22-23,38H,2,5,12-18H2,1H3,(H,34,35,40)/t22-,23+
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107364
PNG
(US8592431, 264)
Show SMILES CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n([C@H]2CC[C@@H](CC2)OCCO)c2ncnn12
Show InChI InChI=1S/C31H34N6O5/c1-2-5-27-26(29(39)36(30-32-19-33-37(27)30)22-12-14-23(15-13-22)41-17-16-38)18-20-8-10-21(11-9-20)24-6-3-4-7-25(24)28-34-31(40)42-35-28/h3-4,6-11,19,22-23,38H,2,5,12-18H2,1H3,(H,34,35,40)/t22-,23-
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107365
PNG
(US8592431, 166)
Show SMILES CCCc1c(Cc2ccc(cc2F)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n([C@@H]2CC[C@H](O)CC2)c2ncnn12
Show InChI InChI=1S/C29H29FN6O4/c1-2-5-25-23(27(38)35(28-31-16-32-36(25)28)19-10-12-20(37)13-11-19)14-18-9-8-17(15-24(18)30)21-6-3-4-7-22(21)26-33-29(39)40-34-26/h3-4,6-9,15-16,19-20,37H,2,5,10-14H2,1H3,(H,33,34,39)/t19-,20+
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107366
PNG
(US8592431, 167)
Show SMILES CCCc1c(Cc2ccc(cc2F)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n([C@H]2CC[C@H](O)CC2)c2ncnn12
Show InChI InChI=1S/C29H29FN6O4/c1-2-5-25-23(27(38)35(28-31-16-32-36(25)28)19-10-12-20(37)13-11-19)14-18-9-8-17(15-24(18)30)21-6-3-4-7-22(21)26-33-29(39)40-34-26/h3-4,6-9,15-16,19-20,37H,2,5,10-14H2,1H3,(H,33,34,39)/t19-,20-
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107367
PNG
(US8592431, 168)
Show SMILES CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n([C@H]2CC[C@@H](CC2)C(=O)OCC)c2ncnn12
Show InChI InChI=1S/C32H34N6O5/c1-3-7-27-26(18-20-10-12-21(13-11-20)24-8-5-6-9-25(24)28-35-32(41)43-36-28)29(39)37(31-33-19-34-38(27)31)23-16-14-22(15-17-23)30(40)42-4-2/h5-6,8-13,19,22-23H,3-4,7,14-18H2,1-2H3,(H,35,36,41)/t22-,23-
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107368
PNG
(US8592431, 169)
Show SMILES CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n([C@H]2CC[C@@H](CC2)c2nc(C)no2)c2ncnn12
Show InChI InChI=1S/C32H32N8O4/c1-3-6-27-26(17-20-9-11-21(12-10-20)24-7-4-5-8-25(24)28-36-32(42)44-38-28)30(41)39(31-33-18-34-40(27)31)23-15-13-22(14-16-23)29-35-19(2)37-43-29/h4-5,7-12,18,22-23H,3,6,13-17H2,1-2H3,(H,36,38,42)/t22-,23-
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
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