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Found 86 hits Enz. Inhib. hit(s) with Target = 'Aldehyde reductase (ALR1)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aldehyde reductase (ALR1)


(Bos taurus (Cattle))
BDBM193848
PNG
(Coumarin-thiazole series I, 6a)
Show SMILES C\C(=N/Nc1nc(cs1)-c1cc2ccccc2oc1=O)c1ccccc1
Show InChI InChI=1S/C20H15N3O2S/c1-13(14-7-3-2-4-8-14)22-23-20-21-17(12-26-20)16-11-15-9-5-6-10-18(15)25-19(16)24/h2-12H,1H3,(H,21,23)/b22-13+
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n/an/a 2.94E+3n/an/an/an/a6.2n/a



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Assay Description
The assay results were obtained at 340 nm and ALR1 inhibitory activity was measured with the absorbance change at this respective wavelength. Each we...


Bioorg Chem 68: 177-186 (2016)


Article DOI: 10.1016/j.bioorg.2016.08.005
BindingDB Entry DOI: 10.7270/Q2445K96
More data for this
Ligand-Target Pair
Aldehyde reductase (ALR1)


(Bos taurus (Cattle))
BDBM50003616
PNG
(2-n-propyl-n-valeric acid | CHEMBL109 | DPA | Di-n...)
Show SMILES CCCC(CCC)C(O)=O
Show InChI InChI=1S/C8H16O2/c1-3-5-7(6-4-2)8(9)10/h7H,3-6H2,1-2H3,(H,9,10)
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n/an/a 5.74E+4n/an/an/an/a6.2n/a



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Assay Description
The assay results were obtained at 340 nm and ALR1 inhibitory activity was measured with the absorbance change at this respective wavelength. Each we...


Bioorg Chem 68: 177-186 (2016)


Article DOI: 10.1016/j.bioorg.2016.08.005
BindingDB Entry DOI: 10.7270/Q2445K96
More data for this
Ligand-Target Pair
Aldehyde reductase (ALR1)


(Bos taurus (Cattle))
BDBM193851
PNG
((E)-3-(2-(2-(1-(3-bromophenyl)ethylidene)hydraziny...)
Show SMILES C\C(=N/Nc1nc(cs1)-c1cc2ccccc2oc1=O)c1cccc(Br)c1
Show InChI InChI=1S/C20H14BrN3O2S/c1-12(13-6-4-7-15(21)9-13)23-24-20-22-17(11-27-20)16-10-14-5-2-3-8-18(14)26-19(16)25/h2-11H,1H3,(H,22,24)/b23-12+
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Assay Description
The assay results were obtained at 340 nm and ALR1 inhibitory activity was measured with the absorbance change at this respective wavelength. Each we...


Bioorg Chem 68: 177-186 (2016)


Article DOI: 10.1016/j.bioorg.2016.08.005
BindingDB Entry DOI: 10.7270/Q2445K96
More data for this
Ligand-Target Pair
Aldehyde reductase (ALR1)


(Bos taurus (Cattle))
BDBM193852
PNG
((E)-3-(2-(2-(1-(4-bromophenyl)ethylidene)hydraziny...)
Show SMILES C\C(=N/Nc1nc(cs1)-c1cc2ccccc2oc1=O)c1ccc(Br)cc1
Show InChI InChI=1S/C20H14BrN3O2S/c1-12(13-6-8-15(21)9-7-13)23-24-20-22-17(11-27-20)16-10-14-4-2-3-5-18(14)26-19(16)25/h2-11H,1H3,(H,22,24)/b23-12+
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n/an/a 1.71E+3n/an/an/an/a6.2n/a



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Assay Description
The assay results were obtained at 340 nm and ALR1 inhibitory activity was measured with the absorbance change at this respective wavelength. Each we...


Bioorg Chem 68: 177-186 (2016)


Article DOI: 10.1016/j.bioorg.2016.08.005
BindingDB Entry DOI: 10.7270/Q2445K96
More data for this
Ligand-Target Pair
Aldehyde reductase (ALR1)


(Bos taurus (Cattle))
BDBM193853
PNG
((E)-3-(2-(2-(1-(2-fluorophenyl)ethylidene)hydrazin...)
Show SMILES C\C(=N/Nc1nc(cs1)-c1cc2ccccc2oc1=O)c1ccccc1F
Show InChI InChI=1S/C20H14FN3O2S/c1-12(14-7-3-4-8-16(14)21)23-24-20-22-17(11-27-20)15-10-13-6-2-5-9-18(13)26-19(15)25/h2-11H,1H3,(H,22,24)/b23-12+
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Assay Description
The assay results were obtained at 340 nm and ALR1 inhibitory activity was measured with the absorbance change at this respective wavelength. Each we...


Bioorg Chem 68: 177-186 (2016)


Article DOI: 10.1016/j.bioorg.2016.08.005
BindingDB Entry DOI: 10.7270/Q2445K96
More data for this
Ligand-Target Pair
Aldehyde reductase (ALR1)


(Bos taurus (Cattle))
BDBM193855
PNG
((E)-3-(2-(2-(1-(4-methoxyphenyl)ethylidene)hydrazi...)
Show SMILES COc1ccc(cc1)C(\C)=N\Nc1nc(cs1)-c1cc2ccccc2oc1=O
Show InChI InChI=1S/C21H17N3O3S/c1-13(14-7-9-16(26-2)10-8-14)23-24-21-22-18(12-28-21)17-11-15-5-3-4-6-19(15)27-20(17)25/h3-12H,1-2H3,(H,22,24)/b23-13+
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n/an/a 7.62E+3n/an/an/an/a6.2n/a



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Assay Description
The assay results were obtained at 340 nm and ALR1 inhibitory activity was measured with the absorbance change at this respective wavelength. Each we...


Bioorg Chem 68: 177-186 (2016)


Article DOI: 10.1016/j.bioorg.2016.08.005
BindingDB Entry DOI: 10.7270/Q2445K96
More data for this
Ligand-Target Pair
Aldehyde reductase (ALR1)


(Bos taurus (Cattle))
BDBM193856
PNG
((E)-3-(2-(2-(1-(3-fluoro-4-methoxyphenyl)ethyliden...)
Show SMILES COc1ccc(cc1F)C(\C)=N\Nc1nc(cs1)-c1cc2ccccc2oc1=O
Show InChI InChI=1S/C21H16FN3O3S/c1-12(13-7-8-19(27-2)16(22)10-13)24-25-21-23-17(11-29-21)15-9-14-5-3-4-6-18(14)28-20(15)26/h3-11H,1-2H3,(H,23,25)/b24-12+
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n/an/a 1.08E+3n/an/an/an/a6.2n/a



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Assay Description
The assay results were obtained at 340 nm and ALR1 inhibitory activity was measured with the absorbance change at this respective wavelength. Each we...


Bioorg Chem 68: 177-186 (2016)


Article DOI: 10.1016/j.bioorg.2016.08.005
BindingDB Entry DOI: 10.7270/Q2445K96
More data for this
Ligand-Target Pair
Aldehyde reductase (ALR1)


(Bos taurus (Cattle))
BDBM193857
PNG
((E)-3-(2-(2-(1-(2-hydroxy-4-methoxyphenyl)ethylide...)
Show SMILES COc1ccc(\C(C)=N\Nc2nc(cs2)-c2cc3ccccc3oc2=O)c(O)c1
Show InChI InChI=1S/C21H17N3O4S/c1-12(15-8-7-14(27-2)10-18(15)25)23-24-21-22-17(11-29-21)16-9-13-5-3-4-6-19(13)28-20(16)26/h3-11,25H,1-2H3,(H,22,24)/b23-12+
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Assay Description
The assay results were obtained at 340 nm and ALR1 inhibitory activity was measured with the absorbance change at this respective wavelength. Each we...


Bioorg Chem 68: 177-186 (2016)


Article DOI: 10.1016/j.bioorg.2016.08.005
BindingDB Entry DOI: 10.7270/Q2445K96
More data for this
Ligand-Target Pair
Aldehyde reductase (ALR1)


(Bos taurus (Cattle))
BDBM193858
PNG
((E)-3-(2-(2-(1-(4-hydroxy-3-methoxyphenyl)ethylide...)
Show SMILES COc1cc(ccc1O)C(\C)=N\Nc1nc(cs1)-c1cc2ccccc2oc1=O
Show InChI InChI=1S/C21H17N3O4S/c1-12(13-7-8-17(25)19(10-13)27-2)23-24-21-22-16(11-29-21)15-9-14-5-3-4-6-18(14)28-20(15)26/h3-11,25H,1-2H3,(H,22,24)/b23-12+
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n/an/a 1.41E+3n/an/an/an/a6.2n/a



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Assay Description
The assay results were obtained at 340 nm and ALR1 inhibitory activity was measured with the absorbance change at this respective wavelength. Each we...


Bioorg Chem 68: 177-186 (2016)


Article DOI: 10.1016/j.bioorg.2016.08.005
BindingDB Entry DOI: 10.7270/Q2445K96
More data for this
Ligand-Target Pair
Aldehyde reductase (ALR1)


(Bos taurus (Cattle))
BDBM193859
PNG
((E)-3-(2-(2-(1-(3-iodo-4-methoxyphenyl)ethylidene)...)
Show SMILES COc1ccc(cc1I)C(\C)=N\Nc1nc(cs1)-c1cc2ccccc2oc1=O
Show InChI InChI=1S/C21H16IN3O3S/c1-12(13-7-8-19(27-2)16(22)10-13)24-25-21-23-17(11-29-21)15-9-14-5-3-4-6-18(14)28-20(15)26/h3-11H,1-2H3,(H,23,25)/b24-12+
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n/an/a 1.44E+4n/an/an/an/a6.2n/a



COMSATS Institute of Information Technology



Assay Description
The assay results were obtained at 340 nm and ALR1 inhibitory activity was measured with the absorbance change at this respective wavelength. Each we...


Bioorg Chem 68: 177-186 (2016)


Article DOI: 10.1016/j.bioorg.2016.08.005
BindingDB Entry DOI: 10.7270/Q2445K96
More data for this
Ligand-Target Pair
Aldehyde reductase (ALR1)


(Bos taurus (Cattle))
BDBM193860
PNG
((E)-3-(2-(2-((2-amino-4-chlorophenyl)(phenyl)methy...)
Show SMILES C\C(=N/Nc1nc(cs1)-c1cc2ccccc2oc1=O)c1ccc(Cl)cc1N
Show InChI InChI=1S/C25H17ClN4O2S/c26-17-10-11-18(20(27)13-17)23(15-6-2-1-3-7-15)29-30-25-28-21(14-33-25)19-12-16-8-4-5-9-22(16)32-24(19)31/h1-14H,27H2,(H,28,30)/b29-23+
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n/an/a 459n/an/an/an/a6.2n/a



COMSATS Institute of Information Technology



Assay Description
The assay results were obtained at 340 nm and ALR1 inhibitory activity was measured with the absorbance change at this respective wavelength. Each we...


Bioorg Chem 68: 177-186 (2016)


Article DOI: 10.1016/j.bioorg.2016.08.005
BindingDB Entry DOI: 10.7270/Q2445K96
More data for this
Ligand-Target Pair
Aldehyde reductase (ALR1)


(Bos taurus (Cattle))
BDBM193861
PNG
(3-(2-(2-(diphenylmethylene)hydrazinyl)thiazol-4-yl...)
Show SMILES O=c1oc2ccccc2cc1-c1csc(NN=C(c2ccccc2)c2ccccc2)n1
Show InChI InChI=1S/C25H17N3O2S/c29-24-20(15-19-13-7-8-14-22(19)30-24)21-16-31-25(26-21)28-27-23(17-9-3-1-4-10-17)18-11-5-2-6-12-18/h1-16H,(H,26,28)
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Assay Description
The assay results were obtained at 340 nm and ALR1 inhibitory activity was measured with the absorbance change at this respective wavelength. Each we...


Bioorg Chem 68: 177-186 (2016)


Article DOI: 10.1016/j.bioorg.2016.08.005
BindingDB Entry DOI: 10.7270/Q2445K96
More data for this
Ligand-Target Pair
Aldehyde reductase (ALR1)


(Bos taurus (Cattle))
BDBM193862
PNG
(Coumarin-thiazole series I, 6o)
Show SMILES C\C(=N/Nc1nc(cs1)-c1cc2ccccc2oc1=O)c1cc2ccccc2oc1=O
Show InChI InChI=1S/C23H15N3O4S/c1-13(16-10-14-6-2-4-8-19(14)29-21(16)27)25-26-23-24-18(12-31-23)17-11-15-7-3-5-9-20(15)30-22(17)28/h2-12H,1H3,(H,24,26)/b25-13+
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n/an/a 8.91E+3n/an/an/an/a6.2n/a



COMSATS Institute of Information Technology



Assay Description
The assay results were obtained at 340 nm and ALR1 inhibitory activity was measured with the absorbance change at this respective wavelength. Each we...


Bioorg Chem 68: 177-186 (2016)


Article DOI: 10.1016/j.bioorg.2016.08.005
BindingDB Entry DOI: 10.7270/Q2445K96
More data for this
Ligand-Target Pair
Aldehyde reductase (ALR1)


(Bos taurus (Cattle))
BDBM193864
PNG
(3-(4-((Butylamino)methyl)-5-thioxo-4,5-dihydro-1,3...)
Show SMILES CCCCNCn1nc(oc1=S)-c1cc2ccccc2oc1=O
Show InChI InChI=1S/C16H17N3O3S/c1-2-3-8-17-10-19-16(23)22-14(18-19)12-9-11-6-4-5-7-13(11)21-15(12)20/h4-7,9,17H,2-3,8,10H2,1H3
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Assay Description
The assay results were obtained at 340 nm and ALR1 inhibitory activity was measured with the absorbance change at this respective wavelength. Each we...


Bioorg Chem 68: 177-186 (2016)


Article DOI: 10.1016/j.bioorg.2016.08.005
BindingDB Entry DOI: 10.7270/Q2445K96
More data for this
Ligand-Target Pair
Aldehyde reductase (ALR1)


(Bos taurus (Cattle))
BDBM193865
PNG
(3-(4-((p-Toluidino)methyl)-5-thioxo-4,5-dihydro-1,...)
Show SMILES Cc1ccc(NCn2nc(oc2=S)-c2cc3ccccc3oc2=O)cc1
Show InChI InChI=1S/C19H15N3O3S/c1-12-6-8-14(9-7-12)20-11-22-19(26)25-17(21-22)15-10-13-4-2-3-5-16(13)24-18(15)23/h2-10,20H,11H2,1H3
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n/an/a 7.11E+3n/an/an/an/a6.2n/a



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Assay Description
The assay results were obtained at 340 nm and ALR1 inhibitory activity was measured with the absorbance change at this respective wavelength. Each we...


Bioorg Chem 68: 177-186 (2016)


Article DOI: 10.1016/j.bioorg.2016.08.005
BindingDB Entry DOI: 10.7270/Q2445K96
More data for this
Ligand-Target Pair
Aldehyde reductase (ALR1)


(Bos taurus (Cattle))
BDBM193867
PNG
(3-(4-((3-Chlorophenylamino)methyl)-5-thioxo-4,5-di...)
Show SMILES Clc1cccc(NCn2nc(oc2=S)-c2cc3ccccc3oc2=O)c1
Show InChI InChI=1S/C18H12ClN3O3S/c19-12-5-3-6-13(9-12)20-10-22-18(26)25-16(21-22)14-8-11-4-1-2-7-15(11)24-17(14)23/h1-9,20H,10H2
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n/an/a 1.52E+4n/an/an/an/a6.2n/a



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Assay Description
The assay results were obtained at 340 nm and ALR1 inhibitory activity was measured with the absorbance change at this respective wavelength. Each we...


Bioorg Chem 68: 177-186 (2016)


Article DOI: 10.1016/j.bioorg.2016.08.005
BindingDB Entry DOI: 10.7270/Q2445K96
More data for this
Ligand-Target Pair
Aldehyde reductase (ALR1)


(Bos taurus (Cattle))
BDBM193868
PNG
(3-(4-((4-Chlorophenylamino)methyl)-5-thioxo-4,5-di...)
Show SMILES Clc1ccc(NCn2nc(oc2=S)-c2cc3ccccc3oc2=O)cc1
Show InChI InChI=1S/C18H12ClN3O3S/c19-12-5-7-13(8-6-12)20-10-22-18(26)25-16(21-22)14-9-11-3-1-2-4-15(11)24-17(14)23/h1-9,20H,10H2
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n/an/a 5.68E+3n/an/an/an/a6.2n/a



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Assay Description
The assay results were obtained at 340 nm and ALR1 inhibitory activity was measured with the absorbance change at this respective wavelength. Each we...


Bioorg Chem 68: 177-186 (2016)


Article DOI: 10.1016/j.bioorg.2016.08.005
BindingDB Entry DOI: 10.7270/Q2445K96
More data for this
Ligand-Target Pair
Aldehyde reductase (ALR1)


(Bos taurus (Cattle))
BDBM193850
PNG
((E)-3-(2-(2-(1-(2-bromophenyl)ethylidene)hydraziny...)
Show SMILES C\C(=N/Nc1nc(cs1)-c1cc2ccccc2oc1=O)c1ccccc1Br
Show InChI InChI=1S/C20H14BrN3O2S/c1-12(14-7-3-4-8-16(14)21)23-24-20-22-17(11-27-20)15-10-13-6-2-5-9-18(13)26-19(15)25/h2-11H,1H3,(H,22,24)/b23-12+
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n/an/a 3.47E+4n/an/an/an/a6.2n/a



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Assay Description
The assay results were obtained at 340 nm and ALR1 inhibitory activity was measured with the absorbance change at this respective wavelength. Each we...


Bioorg Chem 68: 177-186 (2016)


Article DOI: 10.1016/j.bioorg.2016.08.005
BindingDB Entry DOI: 10.7270/Q2445K96
More data for this
Ligand-Target Pair
Aldehyde reductase


(Homo sapiens (human))
BDBM50038843
PNG
((4R)-2-(4-bromo-2-fluorobenzyl)-6-fluoro-1H,2'H,5'...)
Show SMILES Fc1ccc2C(=O)N(Cc3ccc(Br)cc3F)C(=O)[C@]3(CC(=O)NC3=O)c2c1
Show InChI InChI=1S/C19H11BrF2N2O4/c20-10-2-1-9(14(22)5-10)8-24-16(26)12-4-3-11(21)6-13(12)19(18(24)28)7-15(25)23-17(19)27/h1-6H,7-8H2,(H,23,25,27)/t19-/m1/s1
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n/an/a 6.70n/an/an/an/an/an/a



Gifu Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal 6His-tagged human aldehyde reductase expressed in Escherichia coli BL21(DE3) mediated D-glucuronate reduction


Bioorg Med Chem 18: 2485-90 (2010)


Article DOI: 10.1016/j.bmc.2010.02.050
BindingDB Entry DOI: 10.7270/Q2K35TTH
More data for this
Ligand-Target Pair
Aldehyde reductase


(Homo sapiens (human))
BDBM16458
PNG
(2-(3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]m...)
Show SMILES OC(=O)Cn1cc(Cc2nc3cc(ccc3s2)C(F)(F)F)c2ccccc12
Show InChI InChI=1S/C19H13F3N2O2S/c20-19(21,22)12-5-6-16-14(8-12)23-17(27-16)7-11-9-24(10-18(25)26)15-4-2-1-3-13(11)15/h1-6,8-9H,7,10H2,(H,25,26)
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n/an/a 5.60E+3n/an/an/an/an/an/a



The Institute for Diabetes Discovery



Assay Description
The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...


J Med Chem 48: 3141-52 (2005)


Article DOI: 10.1021/jm0492094
BindingDB Entry DOI: 10.7270/Q2J38QSN
More data for this
Ligand-Target Pair
Aldehyde reductase


(Homo sapiens (human))
BDBM16459
PNG
(2-(5-methyl-3-{[5-(trifluoromethyl)-1,3-benzothiaz...)
Show SMILES Cc1ccc2n(CC(O)=O)cc(Cc3nc4cc(ccc4s3)C(F)(F)F)c2c1
Show InChI InChI=1S/C20H15F3N2O2S/c1-11-2-4-16-14(6-11)12(9-25(16)10-19(26)27)7-18-24-15-8-13(20(21,22)23)3-5-17(15)28-18/h2-6,8-9H,7,10H2,1H3,(H,26,27)
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n/an/a 1.02E+4n/an/an/an/an/an/a



The Institute for Diabetes Discovery



Assay Description
The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...


J Med Chem 48: 3141-52 (2005)


Article DOI: 10.1021/jm0492094
BindingDB Entry DOI: 10.7270/Q2J38QSN
More data for this
Ligand-Target Pair
Aldehyde reductase


(Homo sapiens (human))
BDBM16460
PNG
(2-(5-chloro-3-{[5-(trifluoromethyl)-1,3-benzothiaz...)
Show SMILES OC(=O)Cn1cc(Cc2nc3cc(ccc3s2)C(F)(F)F)c2cc(Cl)ccc12
Show InChI InChI=1S/C19H12ClF3N2O2S/c20-12-2-3-15-13(7-12)10(8-25(15)9-18(26)27)5-17-24-14-6-11(19(21,22)23)1-4-16(14)28-17/h1-4,6-8H,5,9H2,(H,26,27)
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n/an/a 4.90E+3n/an/an/an/an/an/a



The Institute for Diabetes Discovery



Assay Description
The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...


J Med Chem 48: 3141-52 (2005)


Article DOI: 10.1021/jm0492094
BindingDB Entry DOI: 10.7270/Q2J38QSN
More data for this
Ligand-Target Pair
Aldehyde reductase


(Homo sapiens (human))
BDBM16461
PNG
(2-(6-bromo-3-{[5-(trifluoromethyl)-1,3-benzothiazo...)
Show SMILES OC(=O)Cn1cc(Cc2nc3cc(ccc3s2)C(F)(F)F)c2ccc(Br)cc12
Show InChI InChI=1S/C19H12BrF3N2O2S/c20-12-2-3-13-10(8-25(9-18(26)27)15(13)7-12)5-17-24-14-6-11(19(21,22)23)1-4-16(14)28-17/h1-4,6-8H,5,9H2,(H,26,27)
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n/an/a 3.40E+3n/an/an/an/an/an/a



The Institute for Diabetes Discovery



Assay Description
The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...


J Med Chem 48: 3141-52 (2005)


Article DOI: 10.1021/jm0492094
BindingDB Entry DOI: 10.7270/Q2J38QSN
More data for this
Ligand-Target Pair
Aldehyde reductase


(Homo sapiens (human))
BDBM16462
PNG
(2-{3-[(6-chloro-1,3-benzothiazol-2-yl)methyl]-1H-i...)
Show SMILES OC(=O)Cn1cc(Cc2nc3ccc(Cl)cc3s2)c2ccccc12
Show InChI InChI=1S/C18H13ClN2O2S/c19-12-5-6-14-16(8-12)24-17(20-14)7-11-9-21(10-18(22)23)15-4-2-1-3-13(11)15/h1-6,8-9H,7,10H2,(H,22,23)
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n/an/a 2.10E+3n/an/an/an/an/an/a



The Institute for Diabetes Discovery



Assay Description
The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...


J Med Chem 48: 3141-52 (2005)


Article DOI: 10.1021/jm0492094
BindingDB Entry DOI: 10.7270/Q2J38QSN
More data for this
Ligand-Target Pair
Aldehyde reductase


(Homo sapiens (human))
BDBM16463
PNG
(2-{3-[(4-fluoro-1,3-benzothiazol-2-yl)methyl]-1H-i...)
Show SMILES OC(=O)Cn1cc(Cc2nc3c(F)cccc3s2)c2ccccc12
Show InChI InChI=1S/C18H13FN2O2S/c19-13-5-3-7-15-18(13)20-16(24-15)8-11-9-21(10-17(22)23)14-6-2-1-4-12(11)14/h1-7,9H,8,10H2,(H,22,23)
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n/an/a 1.10E+4n/an/an/an/an/an/a



The Institute for Diabetes Discovery



Assay Description
The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...


J Med Chem 48: 3141-52 (2005)


Article DOI: 10.1021/jm0492094
BindingDB Entry DOI: 10.7270/Q2J38QSN
More data for this
Ligand-Target Pair
Aldehyde reductase


(Homo sapiens (human))
BDBM16464
PNG
(2-{3-[(5-fluoro-1,3-benzothiazol-2-yl)methyl]-1H-i...)
Show SMILES OC(=O)Cn1cc(Cc2nc3cc(F)ccc3s2)c2ccccc12
Show InChI InChI=1S/C18H13FN2O2S/c19-12-5-6-16-14(8-12)20-17(24-16)7-11-9-21(10-18(22)23)15-4-2-1-3-13(11)15/h1-6,8-9H,7,10H2,(H,22,23)
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n/an/a 6.40E+3n/an/an/an/an/an/a



The Institute for Diabetes Discovery



Assay Description
The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...


J Med Chem 48: 3141-52 (2005)


Article DOI: 10.1021/jm0492094
BindingDB Entry DOI: 10.7270/Q2J38QSN
More data for this
Ligand-Target Pair
Aldehyde reductase


(Homo sapiens (human))
BDBM16465
PNG
(2-{3-[(6-fluoro-1,3-benzothiazol-2-yl)methyl]-1H-i...)
Show SMILES OC(=O)Cn1cc(Cc2nc3ccc(F)cc3s2)c2ccccc12
Show InChI InChI=1S/C18H13FN2O2S/c19-12-5-6-14-16(8-12)24-17(20-14)7-11-9-21(10-18(22)23)15-4-2-1-3-13(11)15/h1-6,8-9H,7,10H2,(H,22,23)
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n/an/a 4.50E+3n/an/an/an/an/an/a



The Institute for Diabetes Discovery



Assay Description
The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...


J Med Chem 48: 3141-52 (2005)


Article DOI: 10.1021/jm0492094
BindingDB Entry DOI: 10.7270/Q2J38QSN
More data for this
Ligand-Target Pair
Aldehyde reductase


(Homo sapiens (human))
BDBM16466
PNG
(2-{3-[(7-fluoro-1,3-benzothiazol-2-yl)methyl]-1H-i...)
Show SMILES OC(=O)Cn1cc(Cc2nc3cccc(F)c3s2)c2ccccc12
Show InChI InChI=1S/C18H13FN2O2S/c19-13-5-3-6-14-18(13)24-16(20-14)8-11-9-21(10-17(22)23)15-7-2-1-4-12(11)15/h1-7,9H,8,10H2,(H,22,23)
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n/an/a 1.80E+4n/an/an/an/an/an/a



The Institute for Diabetes Discovery



Assay Description
The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...


J Med Chem 48: 3141-52 (2005)


Article DOI: 10.1021/jm0492094
BindingDB Entry DOI: 10.7270/Q2J38QSN
More data for this
Ligand-Target Pair
Aldehyde reductase


(Homo sapiens (human))
BDBM16467
PNG
(2-{3-[(5,6-difluoro-1,3-benzothiazol-2-yl)methyl]-...)
Show SMILES OC(=O)Cn1cc(Cc2nc3cc(F)c(F)cc3s2)c2ccccc12
Show InChI InChI=1S/C18H12F2N2O2S/c19-12-6-14-16(7-13(12)20)25-17(21-14)5-10-8-22(9-18(23)24)15-4-2-1-3-11(10)15/h1-4,6-8H,5,9H2,(H,23,24)
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n/an/a 1.30E+4n/an/an/an/an/an/a



The Institute for Diabetes Discovery



Assay Description
The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...


J Med Chem 48: 3141-52 (2005)


Article DOI: 10.1021/jm0492094
BindingDB Entry DOI: 10.7270/Q2J38QSN
More data for this
Ligand-Target Pair
Aldehyde reductase


(Homo sapiens (human))
BDBM16468
PNG
(2-{3-[(4,6-difluoro-1,3-benzothiazol-2-yl)methyl]-...)
Show SMILES OC(=O)Cn1cc(Cc2nc3c(F)cc(F)cc3s2)c2ccccc12
Show InChI InChI=1S/C18H12F2N2O2S/c19-11-6-13(20)18-15(7-11)25-16(21-18)5-10-8-22(9-17(23)24)14-4-2-1-3-12(10)14/h1-4,6-8H,5,9H2,(H,23,24)
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n/an/a 5.10E+3n/an/an/an/an/an/a



The Institute for Diabetes Discovery



Assay Description
The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...


J Med Chem 48: 3141-52 (2005)


Article DOI: 10.1021/jm0492094
BindingDB Entry DOI: 10.7270/Q2J38QSN
More data for this
Ligand-Target Pair
Aldehyde reductase


(Homo sapiens (human))
BDBM16469
PNG
(2-{3-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methy...)
Show SMILES OC(=O)Cn1cc(Cc2nc3c(F)c(F)cc(F)c3s2)c2ccccc12
Show InChI InChI=1S/C18H11F3N2O2S/c19-11-6-12(20)18-17(16(11)21)22-14(26-18)5-9-7-23(8-15(24)25)13-4-2-1-3-10(9)13/h1-4,6-7H,5,8H2,(H,24,25)
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n/an/a 2.70E+4n/an/an/an/an/an/a



The Institute for Diabetes Discovery



Assay Description
The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...


J Med Chem 48: 3141-52 (2005)


Article DOI: 10.1021/jm0492094
BindingDB Entry DOI: 10.7270/Q2J38QSN
More data for this
Ligand-Target Pair
Aldehyde reductase


(Homo sapiens (human))
BDBM16470
PNG
(2-{2-methyl-3-[(4,5,7-trifluoro-1,3-benzothiazol-2...)
Show SMILES Cc1c(Cc2nc3c(F)c(F)cc(F)c3s2)c2ccccc2n1CC(O)=O
Show InChI InChI=1S/C19H13F3N2O2S/c1-9-11(10-4-2-3-5-14(10)24(9)8-16(25)26)6-15-23-18-17(22)12(20)7-13(21)19(18)27-15/h2-5,7H,6,8H2,1H3,(H,25,26)
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n/an/a 1.30E+4n/an/an/an/an/an/a



The Institute for Diabetes Discovery



Assay Description
The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...


J Med Chem 48: 3141-52 (2005)


Article DOI: 10.1021/jm0492094
BindingDB Entry DOI: 10.7270/Q2J38QSN
More data for this
Ligand-Target Pair
Aldehyde reductase


(Homo sapiens (human))
BDBM16471
PNG
(2-{2-phenyl-3-[(4,5,7-trifluoro-1,3-benzothiazol-2...)
Show SMILES OC(=O)Cn1c(c(Cc2nc3c(F)c(F)cc(F)c3s2)c2ccccc12)-c1ccccc1
Show InChI InChI=1S/C24H15F3N2O2S/c25-16-11-17(26)24-22(21(16)27)28-19(32-24)10-15-14-8-4-5-9-18(14)29(12-20(30)31)23(15)13-6-2-1-3-7-13/h1-9,11H,10,12H2,(H,30,31)
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n/an/a 1.60E+4n/an/an/an/an/an/a



The Institute for Diabetes Discovery



Assay Description
The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...


J Med Chem 48: 3141-52 (2005)


Article DOI: 10.1021/jm0492094
BindingDB Entry DOI: 10.7270/Q2J38QSN
More data for this
Ligand-Target Pair
Aldehyde reductase


(Homo sapiens (human))
BDBM16472
PNG
(2-{4-chloro-3-[(4,5,7-trifluoro-1,3-benzothiazol-2...)
Show SMILES OC(=O)Cn1cc(Cc2nc3c(F)c(F)cc(F)c3s2)c2c(Cl)cccc12
Show InChI InChI=1S/C18H10ClF3N2O2S/c19-9-2-1-3-12-15(9)8(6-24(12)7-14(25)26)4-13-23-17-16(22)10(20)5-11(21)18(17)27-13/h1-3,5-6H,4,7H2,(H,25,26)
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n/an/a 1.40E+4n/an/an/an/an/an/a



The Institute for Diabetes Discovery



Assay Description
The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...


J Med Chem 48: 3141-52 (2005)


Article DOI: 10.1021/jm0492094
BindingDB Entry DOI: 10.7270/Q2J38QSN
More data for this
Ligand-Target Pair
Aldehyde reductase


(Homo sapiens (human))
BDBM16473
PNG
(2-{5-chloro-3-[(4,5,7-trifluoro-1,3-benzothiazol-2...)
Show SMILES OC(=O)Cn1cc(Cc2nc3c(F)c(F)cc(F)c3s2)c2cc(Cl)ccc12
Show InChI InChI=1S/C18H10ClF3N2O2S/c19-9-1-2-13-10(4-9)8(6-24(13)7-15(25)26)3-14-23-17-16(22)11(20)5-12(21)18(17)27-14/h1-2,4-6H,3,7H2,(H,25,26)
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n/an/a 1.10E+4n/an/an/an/an/an/a



The Institute for Diabetes Discovery



Assay Description
The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...


J Med Chem 48: 3141-52 (2005)


Article DOI: 10.1021/jm0492094
BindingDB Entry DOI: 10.7270/Q2J38QSN
More data for this
Ligand-Target Pair
Aldehyde reductase


(Homo sapiens (human))
BDBM16474
PNG
(2-{5-fluoro-3-[(4,5,7-trifluoro-1,3-benzothiazol-2...)
Show SMILES OC(=O)Cn1cc(Cc2nc3c(F)c(F)cc(F)c3s2)c2cc(F)ccc12
Show InChI InChI=1S/C18H10F4N2O2S/c19-9-1-2-13-10(4-9)8(6-24(13)7-15(25)26)3-14-23-17-16(22)11(20)5-12(21)18(17)27-14/h1-2,4-6H,3,7H2,(H,25,26)
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n/an/a 2.10E+4n/an/an/an/an/an/a



The Institute for Diabetes Discovery



Assay Description
The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...


J Med Chem 48: 3141-52 (2005)


Article DOI: 10.1021/jm0492094
BindingDB Entry DOI: 10.7270/Q2J38QSN
More data for this
Ligand-Target Pair
Aldehyde reductase


(Homo sapiens (human))
BDBM16475
PNG
(2-{5-bromo-3-[(4,5,7-trifluoro-1,3-benzothiazol-2-...)
Show SMILES OC(=O)Cn1cc(Cc2nc3c(F)c(F)cc(F)c3s2)c2cc(Br)ccc12
Show InChI InChI=1S/C18H10BrF3N2O2S/c19-9-1-2-13-10(4-9)8(6-24(13)7-15(25)26)3-14-23-17-16(22)11(20)5-12(21)18(17)27-14/h1-2,4-6H,3,7H2,(H,25,26)
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n/an/a 4.70E+3n/an/an/an/an/an/a



The Institute for Diabetes Discovery



Assay Description
The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...


J Med Chem 48: 3141-52 (2005)


Article DOI: 10.1021/jm0492094
BindingDB Entry DOI: 10.7270/Q2J38QSN
More data for this
Ligand-Target Pair
Aldehyde reductase


(Homo sapiens (human))
BDBM16476
PNG
(2-{5-methyl-3-[(4,5,7-trifluoro-1,3-benzothiazol-2...)
Show SMILES Cc1ccc2n(CC(O)=O)cc(Cc3nc4c(F)c(F)cc(F)c4s3)c2c1
Show InChI InChI=1S/C19H13F3N2O2S/c1-9-2-3-14-11(4-9)10(7-24(14)8-16(25)26)5-15-23-18-17(22)12(20)6-13(21)19(18)27-15/h2-4,6-7H,5,8H2,1H3,(H,25,26)
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n/an/a 3.40E+4n/an/an/an/an/an/a



The Institute for Diabetes Discovery



Assay Description
The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...


J Med Chem 48: 3141-52 (2005)


Article DOI: 10.1021/jm0492094
BindingDB Entry DOI: 10.7270/Q2J38QSN
More data for this
Ligand-Target Pair
Aldehyde reductase


(Homo sapiens (human))
BDBM16477
PNG
(2-{5-methoxy-3-[(4,5,7-trifluoro-1,3-benzothiazol-...)
Show SMILES COc1ccc2n(CC(O)=O)cc(Cc3nc4c(F)c(F)cc(F)c4s3)c2c1
Show InChI InChI=1S/C19H13F3N2O3S/c1-27-10-2-3-14-11(5-10)9(7-24(14)8-16(25)26)4-15-23-18-17(22)12(20)6-13(21)19(18)28-15/h2-3,5-7H,4,8H2,1H3,(H,25,26)
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n/an/a 2.10E+4n/an/an/an/an/an/a



The Institute for Diabetes Discovery



Assay Description
The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...


J Med Chem 48: 3141-52 (2005)


Article DOI: 10.1021/jm0492094
BindingDB Entry DOI: 10.7270/Q2J38QSN
More data for this
Ligand-Target Pair
Aldehyde reductase


(Homo sapiens (human))
BDBM16478
PNG
(2-[5-(benzyloxy)-3-[(4,5,7-trifluoro-1,3-benzothia...)
Show SMILES OC(=O)Cn1cc(Cc2nc3c(F)c(F)cc(F)c3s2)c2cc(OCc3ccccc3)ccc12
Show InChI InChI=1S/C25H17F3N2O3S/c26-18-10-19(27)25-24(23(18)28)29-21(34-25)8-15-11-30(12-22(31)32)20-7-6-16(9-17(15)20)33-13-14-4-2-1-3-5-14/h1-7,9-11H,8,12-13H2,(H,31,32)
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n/an/a 4.80E+3n/an/an/an/an/an/a



The Institute for Diabetes Discovery



Assay Description
The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...


J Med Chem 48: 3141-52 (2005)


Article DOI: 10.1021/jm0492094
BindingDB Entry DOI: 10.7270/Q2J38QSN
More data for this
Ligand-Target Pair
Aldehyde reductase


(Homo sapiens (human))
BDBM16479
PNG
(2-{5-phenoxy-3-[(4,5,7-trifluoro-1,3-benzothiazol-...)
Show SMILES OC(=O)Cn1cc(Cc2nc3c(F)c(F)cc(F)c3s2)c2cc(Oc3ccccc3)ccc12
Show InChI InChI=1S/C24H15F3N2O3S/c25-17-10-18(26)24-23(22(17)27)28-20(33-24)8-13-11-29(12-21(30)31)19-7-6-15(9-16(13)19)32-14-4-2-1-3-5-14/h1-7,9-11H,8,12H2,(H,30,31)
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n/an/a 1.10E+4n/an/an/an/an/an/a



The Institute for Diabetes Discovery



Assay Description
The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...


J Med Chem 48: 3141-52 (2005)


Article DOI: 10.1021/jm0492094
BindingDB Entry DOI: 10.7270/Q2J38QSN
More data for this
Ligand-Target Pair
Aldehyde reductase


(Homo sapiens (human))
BDBM16480
PNG
(2-{5-phenyl-3-[(4,5,7-trifluoro-1,3-benzothiazol-2...)
Show SMILES OC(=O)Cn1cc(Cc2nc3c(F)c(F)cc(F)c3s2)c2cc(ccc12)-c1ccccc1
Show InChI InChI=1S/C24H15F3N2O2S/c25-17-10-18(26)24-23(22(17)27)28-20(32-24)9-15-11-29(12-21(30)31)19-7-6-14(8-16(15)19)13-4-2-1-3-5-13/h1-8,10-11H,9,12H2,(H,30,31)
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n/an/a 1.00E+4n/an/an/an/an/an/a



The Institute for Diabetes Discovery



Assay Description
The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...


J Med Chem 48: 3141-52 (2005)


Article DOI: 10.1021/jm0492094
BindingDB Entry DOI: 10.7270/Q2J38QSN
More data for this
Ligand-Target Pair
Aldehyde reductase


(Homo sapiens (human))
BDBM16481
PNG
(2-[5-(morpholin-4-yl)-3-[(4,5,7-trifluoro-1,3-benz...)
Show SMILES OC(=O)Cn1cc(Cc2nc3c(F)c(F)cc(F)c3s2)c2cc(ccc12)N1CCOCC1
Show InChI InChI=1S/C22H18F3N3O3S/c23-15-9-16(24)22-21(20(15)25)26-18(32-22)7-12-10-28(11-19(29)30)17-2-1-13(8-14(12)17)27-3-5-31-6-4-27/h1-2,8-10H,3-7,11H2,(H,29,30)
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n/an/a 4.10E+4n/an/an/an/an/an/a



The Institute for Diabetes Discovery



Assay Description
The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...


J Med Chem 48: 3141-52 (2005)


Article DOI: 10.1021/jm0492094
BindingDB Entry DOI: 10.7270/Q2J38QSN
More data for this
Ligand-Target Pair
Aldehyde reductase


(Homo sapiens (human))
BDBM16482
PNG
(2-{6-fluoro-3-[(4,5,7-trifluoro-1,3-benzothiazol-2...)
Show SMILES OC(=O)Cn1cc(Cc2nc3c(F)c(F)cc(F)c3s2)c2ccc(F)cc12
Show InChI InChI=1S/C18H10F4N2O2S/c19-9-1-2-10-8(6-24(7-15(25)26)13(10)4-9)3-14-23-17-16(22)11(20)5-12(21)18(17)27-14/h1-2,4-6H,3,7H2,(H,25,26)
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n/an/a 7.50E+3n/an/an/an/an/an/a



The Institute for Diabetes Discovery



Assay Description
The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...


J Med Chem 48: 3141-52 (2005)


Article DOI: 10.1021/jm0492094
BindingDB Entry DOI: 10.7270/Q2J38QSN
More data for this
Ligand-Target Pair
Aldehyde reductase


(Homo sapiens (human))
BDBM16483
PNG
(2-{6-chloro-3-[(4,5,7-trifluoro-1,3-benzothiazol-2...)
Show SMILES OC(=O)Cn1cc(Cc2nc3c(F)c(F)cc(F)c3s2)c2ccc(Cl)cc12
Show InChI InChI=1S/C18H10ClF3N2O2S/c19-9-1-2-10-8(6-24(7-15(25)26)13(10)4-9)3-14-23-17-16(22)11(20)5-12(21)18(17)27-14/h1-2,4-6H,3,7H2,(H,25,26)
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n/an/a 2.70E+3n/an/an/an/an/an/a



The Institute for Diabetes Discovery



Assay Description
The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...


J Med Chem 48: 3141-52 (2005)


Article DOI: 10.1021/jm0492094
BindingDB Entry DOI: 10.7270/Q2J38QSN
More data for this
Ligand-Target Pair
Aldehyde reductase


(Homo sapiens (human))
BDBM16484
PNG
(2-{6-methyl-3-[(4,5,7-trifluoro-1,3-benzothiazol-2...)
Show SMILES Cc1ccc2c(Cc3nc4c(F)c(F)cc(F)c4s3)cn(CC(O)=O)c2c1
Show InChI InChI=1S/C19H13F3N2O2S/c1-9-2-3-11-10(7-24(8-16(25)26)14(11)4-9)5-15-23-18-17(22)12(20)6-13(21)19(18)27-15/h2-4,6-7H,5,8H2,1H3,(H,25,26)
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n/an/a 1.30E+4n/an/an/an/an/an/a



The Institute for Diabetes Discovery



Assay Description
The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...


J Med Chem 48: 3141-52 (2005)


Article DOI: 10.1021/jm0492094
BindingDB Entry DOI: 10.7270/Q2J38QSN
More data for this
Ligand-Target Pair
Aldehyde reductase


(Homo sapiens (human))
BDBM16485
PNG
(2-{6-methoxy-3-[(4,5,7-trifluoro-1,3-benzothiazol-...)
Show SMILES COc1ccc2c(Cc3nc4c(F)c(F)cc(F)c4s3)cn(CC(O)=O)c2c1
Show InChI InChI=1S/C19H13F3N2O3S/c1-27-10-2-3-11-9(7-24(8-16(25)26)14(11)5-10)4-15-23-18-17(22)12(20)6-13(21)19(18)28-15/h2-3,5-7H,4,8H2,1H3,(H,25,26)
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n/an/a 1.20E+4n/an/an/an/an/an/a



The Institute for Diabetes Discovery



Assay Description
The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...


J Med Chem 48: 3141-52 (2005)


Article DOI: 10.1021/jm0492094
BindingDB Entry DOI: 10.7270/Q2J38QSN
More data for this
Ligand-Target Pair
Aldehyde reductase


(Homo sapiens (human))
BDBM16486
PNG
(2-{6-phenyl-3-[(4,5,7-trifluoro-1,3-benzothiazol-2...)
Show SMILES OC(=O)Cn1cc(Cc2nc3c(F)c(F)cc(F)c3s2)c2ccc(cc12)-c1ccccc1
Show InChI InChI=1S/C24H15F3N2O2S/c25-17-10-18(26)24-23(22(17)27)28-20(32-24)9-15-11-29(12-21(30)31)19-8-14(6-7-16(15)19)13-4-2-1-3-5-13/h1-8,10-11H,9,12H2,(H,30,31)
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n/an/a 6.10E+3n/an/an/an/an/an/a



The Institute for Diabetes Discovery



Assay Description
The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...


J Med Chem 48: 3141-52 (2005)


Article DOI: 10.1021/jm0492094
BindingDB Entry DOI: 10.7270/Q2J38QSN
More data for this
Ligand-Target Pair
Aldehyde reductase


(Homo sapiens (human))
BDBM16487
PNG
(2-[6-(morpholin-4-yl)-3-[(4,5,7-trifluoro-1,3-benz...)
Show SMILES OC(=O)Cn1cc(Cc2nc3c(F)c(F)cc(F)c3s2)c2ccc(cc12)N1CCOCC1
Show InChI InChI=1S/C22H18F3N3O3S/c23-15-9-16(24)22-21(20(15)25)26-18(32-22)7-12-10-28(11-19(29)30)17-8-13(1-2-14(12)17)27-3-5-31-6-4-27/h1-2,8-10H,3-7,11H2,(H,29,30)
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n/an/a 4.40E+4n/an/an/an/an/an/a



The Institute for Diabetes Discovery



Assay Description
The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...


J Med Chem 48: 3141-52 (2005)


Article DOI: 10.1021/jm0492094
BindingDB Entry DOI: 10.7270/Q2J38QSN
More data for this
Ligand-Target Pair
Aldehyde reductase


(Homo sapiens (human))
BDBM16488
PNG
(2-{7-fluoro-3-[(4,5,7-trifluoro-1,3-benzothiazol-2...)
Show SMILES OC(=O)Cn1cc(Cc2nc3c(F)c(F)cc(F)c3s2)c2cccc(F)c12
Show InChI InChI=1S/C18H10F4N2O2S/c19-10-3-1-2-9-8(6-24(17(9)10)7-14(25)26)4-13-23-16-15(22)11(20)5-12(21)18(16)27-13/h1-3,5-6H,4,7H2,(H,25,26)
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n/an/a 7.00E+3n/an/an/an/an/an/a



The Institute for Diabetes Discovery



Assay Description
The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...


J Med Chem 48: 3141-52 (2005)


Article DOI: 10.1021/jm0492094
BindingDB Entry DOI: 10.7270/Q2J38QSN
More data for this
Ligand-Target Pair
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