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Found 1981 hits Enz. Inhib. hit(s) with Target = 'Aldosterone Synthase (CYP11B2)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280322
PNG
(US10029993, Example 215)
Show SMILES CC(C)NC(=O)CN1CCN(CC1)c1nncc(n1)-c1ccc(nc1)C#N
Show InChI InChI=1S/C18H22N8O/c1-13(2)22-17(27)12-25-5-7-26(8-6-25)18-23-16(11-21-24-18)14-3-4-15(9-19)20-10-14/h3-4,10-11,13H,5-8,12H2,1-2H3,(H,22,27)
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n/an/a 29n/an/an/an/a7.425



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280323
PNG
(US10029993, Example 218)
Show SMILES CC(C)NC(=O)CN1CCN(CC1)c1nncc(n1)-c1cccc2CCOCc12
Show InChI InChI=1S/C21H28N6O2/c1-15(2)23-20(28)13-26-7-9-27(10-8-26)21-24-19(12-22-25-21)17-5-3-4-16-6-11-29-14-18(16)17/h3-5,12,15H,6-11,13-14H2,1-2H3,(H,23,28)
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n/an/a 9.80n/an/an/an/a7.425



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280324
PNG
(US10029993, Example 219)
Show SMILES CC(C)NC(=O)CN1CCN(CC1)c1nncc(n1)-c1ccc2OCCc2c1
Show InChI InChI=1S/C20H26N6O2/c1-14(2)22-19(27)13-25-6-8-26(9-7-25)20-23-17(12-21-24-20)15-3-4-18-16(11-15)5-10-28-18/h3-4,11-12,14H,5-10,13H2,1-2H3,(H,22,27)
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n/an/a 3.10n/an/an/an/a7.425



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280325
PNG
(US10029993, Example 220)
Show SMILES CC(C)NC(=O)CN1CCN(CC1)c1nncc(n1)-c1ccc2ncsc2c1
Show InChI InChI=1S/C19H23N7OS/c1-13(2)22-18(27)11-25-5-7-26(8-6-25)19-23-16(10-21-24-19)14-3-4-15-17(9-14)28-12-20-15/h3-4,9-10,12-13H,5-8,11H2,1-2H3,(H,22,27)
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n/an/a 20n/an/an/an/a7.425



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280326
PNG
(US10029993, Example 221)
Show SMILES CC(C)NC(=O)CN1CCN(CC1)c1nncc(n1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C19H23F3N6O/c1-13(2)24-17(29)12-27-7-9-28(10-8-27)18-25-16(11-23-26-18)14-3-5-15(6-4-14)19(20,21)22/h3-6,11,13H,7-10,12H2,1-2H3,(H,24,29)
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n/an/a 2.40n/an/an/an/a7.425



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280327
PNG
(US10029993, Example 222)
Show SMILES CC(C)NC(=O)CN1CCN(CC1)c1nncc(n1)-c1ccc2N(C)NCc2c1
Show InChI InChI=1S/C20H28N8O/c1-14(2)23-19(29)13-27-6-8-28(9-7-27)20-24-17(12-21-25-20)15-4-5-18-16(10-15)11-22-26(18)3/h4-5,10,12,14,22H,6-9,11,13H2,1-3H3,(H,23,29)
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n/an/a 26n/an/an/an/a7.425



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280328
PNG
(US10029993, Example 233)
Show SMILES C(C1CCCCC1)c1cnnc(n1)N1CCOCC1
Show InChI InChI=1S/C14H22N4O/c1-2-4-12(5-3-1)10-13-11-15-17-14(16-13)18-6-8-19-9-7-18/h11-12H,1-10H2
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n/an/a 20n/an/an/an/a7.425



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280329
PNG
(US10029993, Example 236)
Show SMILES Cc1ccccc1-c1cnnc(n1)N(Cc1ccccn1)S(C)(=O)=O
Show InChI InChI=1S/C17H17N5O2S/c1-13-7-3-4-9-15(13)16-11-19-21-17(20-16)22(25(2,23)24)12-14-8-5-6-10-18-14/h3-11H,12H2,1-2H3
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n/an/a 23n/an/an/an/a7.425



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280330
PNG
(US10029993, Example 244)
Show SMILES Cc1ccccc1-c1cnnc(n1)C1CCCN(C1)c1cnccn1
Show InChI InChI=1S/C19H20N6/c1-14-5-2-3-7-16(14)17-11-22-24-19(23-17)15-6-4-10-25(13-15)18-12-20-8-9-21-18/h2-3,5,7-9,11-12,15H,4,6,10,13H2,1H3
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n/an/a 11n/an/an/an/a7.425



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280331
PNG
(US10029993, Example 251)
Show SMILES CC(C)CC(=O)NN1CCN(CC1)c1nncc(n1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C18H23ClN6O/c1-13(2)11-17(26)23-25-9-7-24(8-10-25)18-21-16(12-20-22-18)14-3-5-15(19)6-4-14/h3-6,12-13H,7-11H2,1-2H3,(H,23,26)
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n/an/a 7.5n/an/an/an/a7.425



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280332
PNG
(US10029993, Example 252)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)NC(=O)C(O)C1CCN(CC1)c1nncc(n1)-c1ccc(F)cc1
Show InChI InChI=1S/C24H33FN6O2/c1-30(2)20-9-7-19(8-10-20)27-23(33)22(32)17-11-13-31(14-12-17)24-28-21(15-26-29-24)16-3-5-18(25)6-4-16/h3-6,15,17,19-20,22,32H,7-14H2,1-2H3,(H,27,33)/t19-,20-,22?
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n/an/a 15n/an/an/an/a7.425



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280333
PNG
(US10029993, Example 256)
Show SMILES C(Oc1cnnc(n1)N1CCOCC1)c1ccccc1
Show InChI InChI=1S/C14H16N4O2/c1-2-4-12(5-3-1)11-20-13-10-15-17-14(16-13)18-6-8-19-9-7-18/h1-5,10H,6-9,11H2
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n/an/a 26n/an/an/an/a7.425



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280334
PNG
(US10029993, Example 257)
Show SMILES Clc1ccc(CNc2cnnc(n2)N2CCOCC2)cc1
Show InChI InChI=1S/C14H16ClN5O/c15-12-3-1-11(2-4-12)9-16-13-10-17-19-14(18-13)20-5-7-21-8-6-20/h1-4,10H,5-9H2,(H,16,18,19)
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n/an/a 13n/an/an/an/a7.425



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Aldosterone Synthase (CYP11B2)


(Cercopithecus sabaeus)
BDBM191544
PNG
(US9181272, 314)
Show SMILES NC(=O)N1CCCc2c(Cl)c(cnc12)-c1cncc(CN2CCOCC2=O)c1
Show InChI InChI=1S/C19H20ClN5O3/c20-17-14-2-1-3-25(19(21)27)18(14)23-9-15(17)13-6-12(7-22-8-13)10-24-4-5-28-11-16(24)26/h6-9H,1-5,10-11H2,(H2,21,27)
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n/an/a 5.80n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondr...


US Patent US9181272 (2015)


BindingDB Entry DOI: 10.7270/Q2VX0F93
More data for this
Ligand-Target Pair
Aldosterone Synthase (CYP11B2)


(Cercopithecus sabaeus)
BDBM191545
PNG
(US9181272, 315)
Show SMILES CC(=O)N1CCC(CC1)Oc1cncc(c1)-c1cnc2N(CCCc2c1Cl)C(N)=O
Show InChI InChI=1S/C21H24ClN5O3/c1-13(28)26-7-4-15(5-8-26)30-16-9-14(10-24-11-16)18-12-25-20-17(19(18)22)3-2-6-27(20)21(23)29/h9-12,15H,2-8H2,1H3,(H2,23,29)
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n/an/a 23.4n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondr...


US Patent US9181272 (2015)


BindingDB Entry DOI: 10.7270/Q2VX0F93
More data for this
Ligand-Target Pair
Aldosterone Synthase (CYP11B2)


(Cercopithecus sabaeus)
BDBM191546
PNG
(US9181272, 316)
Show SMILES CC(=O)c1c(F)cncc1-c1cnc2N(CCCc2c1)C(N)=O
Show InChI InChI=1S/C16H15FN4O2/c1-9(22)14-12(7-19-8-13(14)17)11-5-10-3-2-4-21(16(18)23)15(10)20-6-11/h5-8H,2-4H2,1H3,(H2,18,23)
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n/an/a 9.70n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondr...


US Patent US9181272 (2015)


BindingDB Entry DOI: 10.7270/Q2VX0F93
More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM8611
PNG
(4-{5H,6H,7H,8H-imidazo[1,5-a]pyridin-5-yl}benzonit...)
Show SMILES N#Cc1ccc(cc1)C1CCCc2cncn12
Show InChI InChI=1S/C14H13N3/c15-8-11-4-6-12(7-5-11)14-3-1-2-13-9-16-10-17(13)14/h4-7,9-10,14H,1-3H2
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n/an/a 2.09E+4n/an/an/an/a7.432



UNIVERSITAT DES SAARLANDES

US Patent


Assay Description
A suspension of fission yeast (S. pombe PE1) with a cell density of 3˙10^7 cells/ml was prepared on a freshly grown culture using fresh EMMG (pH ...


US Patent US9271963 (2016)


BindingDB Entry DOI: 10.7270/Q2445KBN
More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM8904
PNG
(3-(2-Naphthyl)pyridine | 3-(naphthalen-2-yl)pyridi...)
Show SMILES c1ccc2cc(ccc2c1)-c1cccnc1
Show InChI InChI=1S/C15H11N/c1-2-5-13-10-14(8-7-12(13)4-1)15-6-3-9-16-11-15/h1-11H
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n/an/a 2.11E+3n/an/an/an/a7.432



UNIVERSITAT DES SAARLANDES

US Patent


Assay Description
A suspension of fission yeast (S. pombe PE1) with a cell density of 3˙10^7 cells/ml was prepared on a freshly grown culture using fresh EMMG (pH ...


US Patent US9271963 (2016)


BindingDB Entry DOI: 10.7270/Q2445KBN
More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM8905
PNG
(3-(6-Methoxy-2-naphthyl)pyridine | 3-(6-methoxynap...)
Show SMILES COc1ccc2cc(ccc2c1)-c1cccnc1
Show InChI InChI=1S/C16H13NO/c1-18-16-7-6-12-9-13(4-5-14(12)10-16)15-3-2-8-17-11-15/h2-11H,1H3
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n/an/a 559n/an/an/an/a7.432



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US Patent


Assay Description
A suspension of fission yeast (S. pombe PE1) with a cell density of 3˙10^7 cells/ml was prepared on a freshly grown culture using fresh EMMG (pH ...


US Patent US9271963 (2016)


BindingDB Entry DOI: 10.7270/Q2445KBN
More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM8611
PNG
(4-{5H,6H,7H,8H-imidazo[1,5-a]pyridin-5-yl}benzonit...)
Show SMILES N#Cc1ccc(cc1)C1CCCc2cncn12
Show InChI InChI=1S/C14H13N3/c15-8-11-4-6-12(7-5-11)14-3-1-2-13-9-16-10-17(13)14/h4-7,9-10,14H,1-3H2
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n/an/a 18.7n/an/an/an/a7.432



UNIVERSITAT DES SAARLANDES

US Patent


Assay Description
A suspension of fission yeast (S. pombe PE1) with a cell density of 3˙10^7 cells/ml was prepared on a freshly grown culture using fresh EMMG (pH ...


US Patent US9271963 (2016)


BindingDB Entry DOI: 10.7270/Q2445KBN
More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM8904
PNG
(3-(2-Naphthyl)pyridine | 3-(naphthalen-2-yl)pyridi...)
Show SMILES c1ccc2cc(ccc2c1)-c1cccnc1
Show InChI InChI=1S/C15H11N/c1-2-5-13-10-14(8-7-12(13)4-1)15-6-3-9-16-11-15/h1-11H
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n/an/a 164n/an/an/an/a7.432



UNIVERSITAT DES SAARLANDES

US Patent


Assay Description
A suspension of fission yeast (S. pombe PE1) with a cell density of 3˙10^7 cells/ml was prepared on a freshly grown culture using fresh EMMG (pH ...


US Patent US9271963 (2016)


BindingDB Entry DOI: 10.7270/Q2445KBN
More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM8905
PNG
(3-(6-Methoxy-2-naphthyl)pyridine | 3-(6-methoxynap...)
Show SMILES COc1ccc2cc(ccc2c1)-c1cccnc1
Show InChI InChI=1S/C16H13NO/c1-18-16-7-6-12-9-13(4-5-14(12)10-16)15-3-2-8-17-11-15/h2-11H,1H3
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n/an/a 100n/an/an/an/a7.432



UNIVERSITAT DES SAARLANDES

US Patent


Assay Description
A suspension of fission yeast (S. pombe PE1) with a cell density of 3˙10^7 cells/ml was prepared on a freshly grown culture using fresh EMMG (pH ...


US Patent US9271963 (2016)


BindingDB Entry DOI: 10.7270/Q2445KBN
More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280267
PNG
(US10029993, Example 12)
Show SMILES Cc1ccccc1-c1cnnc(n1)N1CCN(CC(=O)NC2CC[C@@](C)(O)CC2)CC1
Show InChI InChI=1S/C23H32N6O2/c1-17-5-3-4-6-19(17)20-15-24-27-22(26-20)29-13-11-28(12-14-29)16-21(30)25-18-7-9-23(2,31)10-8-18/h3-6,15,18,31H,7-14,16H2,1-2H3,(H,25,30)/t18?,23-
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280268
PNG
(US10029993, Example 16)
Show SMILES CC(C)[C@@H](CO)NC(=O)CN1CCN(CC1)c1nncc(n1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C21H27F3N6O2/c1-14(2)18(13-31)26-19(32)12-29-7-9-30(10-8-29)20-27-17(11-25-28-20)15-3-5-16(6-4-15)21(22,23)24/h3-6,11,14,18,31H,7-10,12-13H2,1-2H3,(H,26,32)/t18-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280269
PNG
(US10029993, Example 18)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)NC(=O)CN1CCN(CC1)c1nncc(n1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C23H32ClN7O/c1-29(2)20-9-7-19(8-10-20)26-22(32)16-30-11-13-31(14-12-30)23-27-21(15-25-28-23)17-3-5-18(24)6-4-17/h3-6,15,19-20H,7-14,16H2,1-2H3,(H,26,32)/t19-,20-
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280270
PNG
(US10029993, Example 19)
Show SMILES CO[C@H]1CC[C@@H](CC1)NC(=O)CN1CCN(CC1)c1nncc(n1)-c1ccc2n(C)ncc2c1
Show InChI InChI=1S/C24H32N8O2/c1-30-22-8-3-17(13-18(22)14-26-30)21-15-25-29-24(28-21)32-11-9-31(10-12-32)16-23(33)27-19-4-6-20(34-2)7-5-19/h3,8,13-15,19-20H,4-7,9-12,16H2,1-2H3,(H,27,33)/t19-,20-
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280271
PNG
(US10029993, Example 22)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)NC(=O)CN1CCN(CC1)c1nncc(n1)-c1ccc(F)cc1
Show InChI InChI=1S/C23H32FN7O/c1-29(2)20-9-7-19(8-10-20)26-22(32)16-30-11-13-31(14-12-30)23-27-21(15-25-28-23)17-3-5-18(24)6-4-17/h3-6,15,19-20H,7-14,16H2,1-2H3,(H,26,32)/t19-,20-
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280272
PNG
(US10029993, Example 26)
Show SMILES Fc1ccc(cc1)-c1cnnc(n1)N1CCN(CC(=O)N[C@H]2CC[C@@H](CC2)N2CCNC(=O)C2)CC1
Show InChI InChI=1S/C25H33FN8O2/c26-19-3-1-18(2-4-19)22-15-28-31-25(30-22)33-13-11-32(12-14-33)16-24(36)29-20-5-7-21(8-6-20)34-10-9-27-23(35)17-34/h1-4,15,20-21H,5-14,16-17H2,(H,27,35)(H,29,36)/t20-,21-
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280273
PNG
(US10029993, Example 27)
Show SMILES Clc1ccc(cc1)-c1cnnc(n1)N1CCN(CC(=O)NC2CCS(=O)(=O)CC2)CC1
Show InChI InChI=1S/C20H25ClN6O3S/c21-16-3-1-15(2-4-16)18-13-22-25-20(24-18)27-9-7-26(8-10-27)14-19(28)23-17-5-11-31(29,30)12-6-17/h1-4,13,17H,5-12,14H2,(H,23,28)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280274
PNG
(US10029993, Example 28)
Show SMILES Fc1ccc(cc1)-c1cnnc(n1)N1CCN(CC(=O)N[C@H]2CC[C@@H](CC2)N2CCOCC2)CC1
Show InChI InChI=1S/C25H34FN7O2/c26-20-3-1-19(2-4-20)23-17-27-30-25(29-23)33-11-9-31(10-12-33)18-24(34)28-21-5-7-22(8-6-21)32-13-15-35-16-14-32/h1-4,17,21-22H,5-16,18H2,(H,28,34)/t21-,22-
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280275
PNG
(US10029993, Example 29)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)NC(=O)CN1CCN(CC1)c1nncc(n1)-c1ccccc1C
Show InChI InChI=1S/C24H35N7O/c1-18-6-4-5-7-21(18)22-16-25-28-24(27-22)31-14-12-30(13-15-31)17-23(32)26-19-8-10-20(11-9-19)29(2)3/h4-7,16,19-20H,8-15,17H2,1-3H3,(H,26,32)/t19-,20-
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280276
PNG
(US10029993, Example 38)
Show SMILES Fc1ccc(cc1)-c1cnnc(n1)N1CCN(CC(=O)NC2CCN(CC(=O)N3CCOCC3)CC2)CC1
Show InChI InChI=1S/C26H35FN8O3/c27-21-3-1-20(2-4-21)23-17-28-31-26(30-23)35-11-9-33(10-12-35)18-24(36)29-22-5-7-32(8-6-22)19-25(37)34-13-15-38-16-14-34/h1-4,17,22H,5-16,18-19H2,(H,29,36)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280277
PNG
(US10029993, Example 40)
Show SMILES CN([C@H]1CC[C@@H](CC1)NC(=O)CN1CCN(CC1)c1nncc(n1)-c1ccc(F)cc1)C(C)=O
Show InChI InChI=1S/C24H32FN7O2/c1-17(33)30(2)21-9-7-20(8-10-21)27-23(34)16-31-11-13-32(14-12-31)24-28-22(15-26-29-24)18-3-5-19(25)6-4-18/h3-6,15,20-21H,7-14,16H2,1-2H3,(H,27,34)/t20-,21-
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280278
PNG
(US10029993, Example 44)
Show SMILES CNC(=O)CN1CCC(CC1)NC(=O)CN1CCN(CC1)c1nncc(n1)-c1ccc(F)cc1
Show InChI InChI=1S/C23H31FN8O2/c1-25-21(33)15-30-8-6-19(7-9-30)27-22(34)16-31-10-12-32(13-11-31)23-28-20(14-26-29-23)17-2-4-18(24)5-3-17/h2-5,14,19H,6-13,15-16H2,1H3,(H,25,33)(H,27,34)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280279
PNG
(US10029993, Example 47)
Show SMILES Fc1ccc(cc1)-c1cnnc(n1)N1CCN(CC(=O)NCCN2CCS(=O)(=O)CC2)CC1
Show InChI InChI=1S/C21H28FN7O3S/c22-18-3-1-17(2-4-18)19-15-24-26-21(25-19)29-9-7-28(8-10-29)16-20(30)23-5-6-27-11-13-33(31,32)14-12-27/h1-4,15H,5-14,16H2,(H,23,30)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280280
PNG
(US10029993, Example 48)
Show SMILES CC(=O)N[C@H]1CC[C@@H](CC1)NC(=O)CN1CCN(CC1)c1nncc(n1)-c1ccc(C)cc1
Show InChI InChI=1S/C24H33N7O2/c1-17-3-5-19(6-4-17)22-15-25-29-24(28-22)31-13-11-30(12-14-31)16-23(33)27-21-9-7-20(8-10-21)26-18(2)32/h3-6,15,20-21H,7-14,16H2,1-2H3,(H,26,32)(H,27,33)/t20-,21-
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280281
PNG
(US10029993, Example 50)
Show SMILES Cc1ccc(cc1)-c1cnnc(n1)N1CCN(CC(=O)N[C@H]2CC[C@@H](CC2)S(C)(=O)=O)CC1
Show InChI InChI=1S/C23H32N6O3S/c1-17-3-5-18(6-4-17)21-15-24-27-23(26-21)29-13-11-28(12-14-29)16-22(30)25-19-7-9-20(10-8-19)33(2,31)32/h3-6,15,19-20H,7-14,16H2,1-2H3,(H,25,30)/t19-,20-
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280282
PNG
(US10029993, Example 54)
Show SMILES CN1CC[C@@H](CC1=O)NC(=O)CN1CCN(CC1)c1nncc(n1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C21H26ClN7O2/c1-27-7-6-17(12-20(27)31)24-19(30)14-28-8-10-29(11-9-28)21-25-18(13-23-26-21)15-2-4-16(22)5-3-15/h2-5,13,17H,6-12,14H2,1H3,(H,24,30)/t17-/m0/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280283
PNG
(US10029993, Example 55)
Show SMILES CNC(=O)CO[C@H]1CC[C@@H](CC1)NC(=O)CN1CCN(CC1)c1nncc(n1)-c1ccc(F)cc1
Show InChI InChI=1S/C24H32FN7O3/c1-26-23(34)16-35-20-8-6-19(7-9-20)28-22(33)15-31-10-12-32(13-11-31)24-29-21(14-27-30-24)17-2-4-18(25)5-3-17/h2-5,14,19-20H,6-13,15-16H2,1H3,(H,26,34)(H,28,33)/t19-,20-
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280284
PNG
(US10029993, Example 59)
Show SMILES NC(=O)N1CCC(O)(CNC(=O)CN2CCN(CC2)c2nncc(n2)-c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C22H29ClN8O3/c23-17-3-1-16(2-4-17)18-13-26-28-21(27-18)31-11-9-29(10-12-31)14-19(32)25-15-22(34)5-7-30(8-6-22)20(24)33/h1-4,13,34H,5-12,14-15H2,(H2,24,33)(H,25,32)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280285
PNG
(US10029993, Example 62)
Show SMILES Cc1ccc(cc1)-c1cnnc(n1)N1CCN(CC(=O)NC2CCN(CCNS(C)(=O)=O)CC2)CC1
Show InChI InChI=1S/C24H36N8O3S/c1-19-3-5-20(6-4-19)22-17-25-29-24(28-22)32-15-13-31(14-16-32)18-23(33)27-21-7-10-30(11-8-21)12-9-26-36(2,34)35/h3-6,17,21,26H,7-16,18H2,1-2H3,(H,27,33)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280286
PNG
(US10029993, Example 64)
Show SMILES OC1CCN(CC1)[C@H]1CC[C@@H](CC1)NC(=O)CN1CCN(CC1)c1nncc(n1)-c1ccc(F)cc1
Show InChI InChI=1S/C26H36FN7O2/c27-20-3-1-19(2-4-20)24-17-28-31-26(30-24)34-15-13-32(14-16-34)18-25(36)29-21-5-7-22(8-6-21)33-11-9-23(35)10-12-33/h1-4,17,21-23,35H,5-16,18H2,(H,29,36)/t21-,22-
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280287
PNG
(US10029993, Example 71)
Show SMILES CN(C)C(=O)Cn1cc(NC(=O)CN2CCN(CC2)c2nncc(n2)-c2ccc(F)cc2)cn1
Show InChI InChI=1S/C22H26FN9O2/c1-29(2)21(34)15-32-13-18(11-25-32)26-20(33)14-30-7-9-31(10-8-30)22-27-19(12-24-28-22)16-3-5-17(23)6-4-16/h3-6,11-13H,7-10,14-15H2,1-2H3,(H,26,33)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280288
PNG
(US10029993, Example 75)
Show SMILES CN(C)C(=O)Cn1cc(NC(=O)CN2CCN(CC2)c2nncc(n2)-c2ccc(C)cc2)cn1
Show InChI InChI=1S/C23H29N9O2/c1-17-4-6-18(7-5-17)20-13-24-28-23(27-20)31-10-8-30(9-11-31)15-21(33)26-19-12-25-32(14-19)16-22(34)29(2)3/h4-7,12-14H,8-11,15-16H2,1-3H3,(H,26,33)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280289
PNG
(US10029993, Example 76)
Show SMILES CN(C)C(=O)Cn1cc(NC(=O)CN2CCN(CC2)c2nncc(n2)-c2ccc(Cl)cc2)cn1
Show InChI InChI=1S/C22H26ClN9O2/c1-29(2)21(34)15-32-13-18(11-25-32)26-20(33)14-30-7-9-31(10-8-30)22-27-19(12-24-28-22)16-3-5-17(23)6-4-16/h3-6,11-13H,7-10,14-15H2,1-2H3,(H,26,33)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280290
PNG
(US10029993, Example 79)
Show SMILES CNC(=O)Cn1cc(NC(=O)CN2CCN(CC2)c2nncc(n2)-c2ccc(C)cc2)cn1
Show InChI InChI=1S/C22H27N9O2/c1-16-3-5-17(6-4-16)19-12-24-28-22(27-19)30-9-7-29(8-10-30)14-21(33)26-18-11-25-31(13-18)15-20(32)23-2/h3-6,11-13H,7-10,14-15H2,1-2H3,(H,23,32)(H,26,33)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.5n/an/an/an/a7.425



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280291
PNG
(US10029993, Example 80)
Show SMILES CNC(=O)Cn1cc(NC(=O)CN2CCN(CC2)c2nncc(n2)-c2ccc(F)cc2)cn1
Show InChI InChI=1S/C21H24FN9O2/c1-23-19(32)14-31-12-17(10-25-31)26-20(33)13-29-6-8-30(9-7-29)21-27-18(11-24-28-21)15-2-4-16(22)5-3-15/h2-5,10-12H,6-9,13-14H2,1H3,(H,23,32)(H,26,33)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.5n/an/an/an/a7.425



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280292
PNG
(US10029993, Example 81)
Show SMILES CNC(=O)Cn1cc(NC(=O)CN2CCN(CC2)c2nncc(n2)-c2ccc(Cl)cc2)cn1
Show InChI InChI=1S/C21H24ClN9O2/c1-23-19(32)14-31-12-17(10-25-31)26-20(33)13-29-6-8-30(9-7-29)21-27-18(11-24-28-21)15-2-4-16(22)5-3-15/h2-5,10-12H,6-9,13-14H2,1H3,(H,23,32)(H,26,33)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.70n/an/an/an/a7.425



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280293
PNG
(US10029993, Example 82)
Show SMILES CN1CCNC(=O)[C@@]11CCC(CC1)NC(=O)CN1CCN(CC1)c1nncc(n1)-c1ccc(F)cc1
Show InChI InChI=1S/C25H33FN8O2/c1-32-11-10-27-23(36)25(32)8-6-20(7-9-25)29-22(35)17-33-12-14-34(15-13-33)24-30-21(16-28-31-24)18-2-4-19(26)5-3-18/h2-5,16,20H,6-15,17H2,1H3,(H,27,36)(H,29,35)/t20?,25-
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 12n/an/an/an/a7.425



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280294
PNG
(US10029993, Example 83)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)NC(=O)CN1CCN(CC1)c1nncc(n1)-c1cc(F)ccc1F
Show InChI InChI=1S/C23H31F2N7O/c1-30(2)18-6-4-17(5-7-18)27-22(33)15-31-9-11-32(12-10-31)23-28-21(14-26-29-23)19-13-16(24)3-8-20(19)25/h3,8,13-14,17-18H,4-7,9-12,15H2,1-2H3,(H,27,33)/t17-,18-
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 7.60n/an/an/an/a7.425



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
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