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Found 710 hits Enz. Inhib. hit(s) with Target = 'Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM201506
PNG
(US9187424, 273)
Show SMILES COc1cnc(NC(=O)C2=C(CC(NC2=O)(c2ccc(OCCCCC(F)(F)F)cc2)C(F)(F)F)c2ccc(C)cc2)cn1
Show InChI InChI=1S/C30H28F6N4O4/c1-18-5-7-19(8-6-18)22-15-28(30(34,35)36,20-9-11-21(12-10-20)44-14-4-3-13-29(31,32)33)40-27(42)25(22)26(41)39-23-16-38-24(43-2)17-37-23/h5-12,16-17H,3-4,13-15H2,1-2H3,(H,40,42)(H,37,39,41)
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US Patent
n/an/a 21n/an/an/an/a7.425



Bristol-Myers Squibb Company

US Patent


Assay Description
MGAT2 enzyme was assayed using membranes isolated from Sf9 cells expressing the recombinant human MGAT2 cDNA with 2-monooleoylglycerol and [3H]-oleoy...


US Patent US9187424 (2015)


BindingDB Entry DOI: 10.7270/Q2FQ9VFG
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM201510
PNG
(US9187424, 277)
Show SMILES Fc1cc(OCCCC(F)(F)F)ccc1C1(CC(=C(c2nn[nH]n2)C(=O)N1)c1ccc(CC2CC2)cc1)C(F)(F)F
Show InChI InChI=1S/C27H24F7N5O2/c28-21-13-18(41-11-1-10-26(29,30)31)8-9-20(21)25(27(32,33)34)14-19(22(24(40)35-25)23-36-38-39-37-23)17-6-4-16(5-7-17)12-15-2-3-15/h4-9,13,15H,1-3,10-12,14H2,(H,35,40)(H,36,37,38,39)
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n/an/a 2n/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in CORNING Falcon 96-well Polypropylene plates, in a total volume of 60 uL of 50 mM Potassium Phosphate buff...


US Patent US9187424 (2015)


BindingDB Entry DOI: 10.7270/Q2FQ9VFG
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM201511
PNG
(US9187424, 278)
Show SMILES Cc1ccc(cc1)C1=C(c2nn[nH]n2)C(=O)NC(C1)(c1ccc(OCCCCC(F)(F)F)cc1F)C(F)(F)F
Show InChI InChI=1S/C25H22F7N5O2/c1-14-4-6-15(7-5-14)17-13-23(25(30,31)32,33-22(38)20(17)21-34-36-37-35-21)18-9-8-16(12-19(18)26)39-11-3-2-10-24(27,28)29/h4-9,12H,2-3,10-11,13H2,1H3,(H,33,38)(H,34,35,36,37)
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n/an/a 2n/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in CORNING Falcon 96-well Polypropylene plates, in a total volume of 60 uL of 50 mM Potassium Phosphate buff...


US Patent US9187424 (2015)


BindingDB Entry DOI: 10.7270/Q2FQ9VFG
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM201512
PNG
(US9187424, 279)
Show SMILES Cc1ccc(cc1)C1=C(NC(=O)CS(C)(=O)=O)C(=O)NC(C1)(c1ccc(OCc2ccccc2)cc1)C(F)(F)F
Show InChI InChI=1S/C29H27F3N2O5S/c1-19-8-10-21(11-9-19)24-16-28(29(30,31)32,34-27(36)26(24)33-25(35)18-40(2,37)38)22-12-14-23(15-13-22)39-17-20-6-4-3-5-7-20/h3-15H,16-18H2,1-2H3,(H,33,35)(H,34,36)
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n/an/a 2n/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in CORNING Falcon 96-well Polypropylene plates, in a total volume of 60 uL of 50 mM Potassium Phosphate buff...


US Patent US9187424 (2015)


BindingDB Entry DOI: 10.7270/Q2FQ9VFG
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM201513
PNG
(US9187424, 280)
Show SMILES FC(F)Oc1ccc(cc1)C1=C(C(=O)Nc2cccnc2)C(=O)NC(C1)(c1ccc(OCCCC(F)(F)F)cc1)C(F)(F)F
Show InChI InChI=1S/C29H23F8N3O4/c30-26(31)44-21-8-4-17(5-9-21)22-15-27(29(35,36)37,18-6-10-20(11-7-18)43-14-2-12-28(32,33)34)40-25(42)23(22)24(41)39-19-3-1-13-38-16-19/h1,3-11,13,16,26H,2,12,14-15H2,(H,39,41)(H,40,42)
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n/an/a 2n/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in CORNING Falcon 96-well Polypropylene plates, in a total volume of 60 uL of 50 mM Potassium Phosphate buff...


US Patent US9187424 (2015)


BindingDB Entry DOI: 10.7270/Q2FQ9VFG
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM201514
PNG
(US9187424, 281)
Show SMILES Cc1cc(NC(=O)C2=C(CC(NC2=O)(c2ccc(OCCCC(F)(F)F)cc2)C(F)(F)F)c2ccc(C)cc2)on1
Show InChI InChI=1S/C28H25F6N3O4/c1-16-4-6-18(7-5-16)21-15-26(28(32,33)34,19-8-10-20(11-9-19)40-13-3-12-27(29,30)31)36-25(39)23(21)24(38)35-22-14-17(2)37-41-22/h4-11,14H,3,12-13,15H2,1-2H3,(H,35,38)(H,36,39)
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n/an/a 3n/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in CORNING Falcon 96-well Polypropylene plates, in a total volume of 60 uL of 50 mM Potassium Phosphate buff...


US Patent US9187424 (2015)


BindingDB Entry DOI: 10.7270/Q2FQ9VFG
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM201515
PNG
(US9187424, 282)
Show SMILES CCOP(=O)(CC(=O)NC1=C(CC(NC1=O)(c1ccc(OCCCC(F)(F)F)cc1)C(F)(F)F)c1ccc(C)cc1)OCC
Show InChI InChI=1S/C29H33F6N2O6P/c1-4-42-44(40,43-5-2)18-24(38)36-25-23(20-9-7-19(3)8-10-20)17-27(29(33,34)35,37-26(25)39)21-11-13-22(14-12-21)41-16-6-15-28(30,31)32/h7-14H,4-6,15-18H2,1-3H3,(H,36,38)(H,37,39)
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n/an/a 3n/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in CORNING Falcon 96-well Polypropylene plates, in a total volume of 60 uL of 50 mM Potassium Phosphate buff...


US Patent US9187424 (2015)


BindingDB Entry DOI: 10.7270/Q2FQ9VFG
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM201516
PNG
(US9187424, 283)
Show SMILES CCOc1ccc(cc1)C1=C(c2nn[nH]n2)C(=O)NC(C1)(c1ccc(OCCCCCC(F)(F)F)cc1F)C(F)(F)F
Show InChI InChI=1S/C27H26F7N5O3/c1-2-41-17-8-6-16(7-9-17)19-15-25(27(32,33)34,35-24(40)22(19)23-36-38-39-37-23)20-11-10-18(14-21(20)28)42-13-5-3-4-12-26(29,30)31/h6-11,14H,2-5,12-13,15H2,1H3,(H,35,40)(H,36,37,38,39)
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n/an/a 3n/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in CORNING Falcon 96-well Polypropylene plates, in a total volume of 60 uL of 50 mM Potassium Phosphate buff...


US Patent US9187424 (2015)


BindingDB Entry DOI: 10.7270/Q2FQ9VFG
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM201517
PNG
(US9187424, 284)
Show SMILES Fc1cc(OCCCCCC(F)(F)F)ccc1C1(CC(=C(c2nn[nH]n2)C(=O)N1)c1ccc(CC(F)(F)F)cc1)C(F)(F)F
Show InChI InChI=1S/C27H23F10N5O2/c28-20-12-17(44-11-3-1-2-10-25(29,30)31)8-9-19(20)24(27(35,36)37)14-18(21(23(43)38-24)22-39-41-42-40-22)16-6-4-15(5-7-16)13-26(32,33)34/h4-9,12H,1-3,10-11,13-14H2,(H,38,43)(H,39,40,41,42)
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n/an/a 4n/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in CORNING Falcon 96-well Polypropylene plates, in a total volume of 60 uL of 50 mM Potassium Phosphate buff...


US Patent US9187424 (2015)


BindingDB Entry DOI: 10.7270/Q2FQ9VFG
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM201518
PNG
(US9187424, 285)
Show SMILES Cc1ccc(cc1)C1=C(c2nn[nH]n2)C(=O)NC(C1)(c1ccc(OCCC2CC2)cc1)C(F)(F)F
Show InChI InChI=1S/C25H24F3N5O2/c1-15-2-6-17(7-3-15)20-14-24(25(26,27)28,29-23(34)21(20)22-30-32-33-31-22)18-8-10-19(11-9-18)35-13-12-16-4-5-16/h2-3,6-11,16H,4-5,12-14H2,1H3,(H,29,34)(H,30,31,32,33)
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n/an/a 4n/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in CORNING Falcon 96-well Polypropylene plates, in a total volume of 60 uL of 50 mM Potassium Phosphate buff...


US Patent US9187424 (2015)


BindingDB Entry DOI: 10.7270/Q2FQ9VFG
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM201519
PNG
(US9187424, 286)
Show SMILES Cc1ccc(C2=C(c3nn[nH]n3)C(=O)NC(C2)(c2ccc(OCCCC(F)(F)F)cc2)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C24H20F7N5O2/c1-13-3-8-16(18(25)11-13)17-12-22(24(29,30)31,32-21(37)19(17)20-33-35-36-34-20)14-4-6-15(7-5-14)38-10-2-9-23(26,27)28/h3-8,11H,2,9-10,12H2,1H3,(H,32,37)(H,33,34,35,36)
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n/an/a 4n/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in CORNING Falcon 96-well Polypropylene plates, in a total volume of 60 uL of 50 mM Potassium Phosphate buff...


US Patent US9187424 (2015)


BindingDB Entry DOI: 10.7270/Q2FQ9VFG
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM201520
PNG
(US9187424, 287)
Show SMILES Cc1ccc(cc1)C1=C(c2nn[nH]n2)C(=O)NC(C1)(c1ccc(OCCCCCC(F)(F)F)c(C)c1)C(F)(F)F
Show InChI InChI=1S/C27H27F6N5O2/c1-16-6-8-18(9-7-16)20-15-25(27(31,32)33,34-24(39)22(20)23-35-37-38-36-23)19-10-11-21(17(2)14-19)40-13-5-3-4-12-26(28,29)30/h6-11,14H,3-5,12-13,15H2,1-2H3,(H,34,39)(H,35,36,37,38)
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n/an/a 13n/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in CORNING Falcon 96-well Polypropylene plates, in a total volume of 60 uL of 50 mM Potassium Phosphate buff...


US Patent US9187424 (2015)


BindingDB Entry DOI: 10.7270/Q2FQ9VFG
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM201521
PNG
(US9187424, 288)
Show SMILES Cc1ccc(cc1)C1=C(c2nn[nH]n2)C(=O)NC(C1)(c1ccc(OCC2CC(F)(F)C2)cc1)C(F)(F)F
Show InChI InChI=1S/C25H22F5N5O2/c1-14-2-4-16(5-3-14)19-12-24(25(28,29)30,31-22(36)20(19)21-32-34-35-33-21)17-6-8-18(9-7-17)37-13-15-10-23(26,27)11-15/h2-9,15H,10-13H2,1H3,(H,31,36)(H,32,33,34,35)
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n/an/a 19n/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in CORNING Falcon 96-well Polypropylene plates, in a total volume of 60 uL of 50 mM Potassium Phosphate buff...


US Patent US9187424 (2015)


BindingDB Entry DOI: 10.7270/Q2FQ9VFG
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM201522
PNG
(US9187424, 289)
Show SMILES Cc1ccc(cc1)C1=C(c2nn[nH]n2)C(=O)NC(C1)(c1ccc(cc1)C#CCC1CCCCC1)C(F)(F)F
Show InChI InChI=1S/C29H28F3N5O/c1-19-10-14-22(15-11-19)24-18-28(29(30,31)32,33-27(38)25(24)26-34-36-37-35-26)23-16-12-21(13-17-23)9-5-8-20-6-3-2-4-7-20/h10-17,20H,2-4,6-8,18H2,1H3,(H,33,38)(H,34,35,36,37)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in CORNING Falcon 96-well Polypropylene plates, in a total volume of 60 uL of 50 mM Potassium Phosphate buff...


US Patent US9187424 (2015)


BindingDB Entry DOI: 10.7270/Q2FQ9VFG
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM201523
PNG
(US9187424, 290)
Show SMILES Cc1ccc(cc1)C1=C(c2nn[nH]n2)C(=O)NC(C1)(c1ccc(cc1)C#CCOCc1ccccc1)C(F)(F)F
Show InChI InChI=1S/C30H24F3N5O2/c1-20-9-13-23(14-10-20)25-18-29(30(31,32)33,34-28(39)26(25)27-35-37-38-36-27)24-15-11-21(12-16-24)8-5-17-40-19-22-6-3-2-4-7-22/h2-4,6-7,9-16H,17-19H2,1H3,(H,34,39)(H,35,36,37,38)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in CORNING Falcon 96-well Polypropylene plates, in a total volume of 60 uL of 50 mM Potassium Phosphate buff...


US Patent US9187424 (2015)


BindingDB Entry DOI: 10.7270/Q2FQ9VFG
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM201524
PNG
(US9187424, 291)
Show SMILES Cc1ccc(cc1)C1=C(c2nn[nH]n2)C(=O)NC(C1)(c1ccc(cc1)C#CC1CCCCC1)C(F)(F)F
Show InChI InChI=1S/C28H26F3N5O/c1-18-7-13-21(14-8-18)23-17-27(28(29,30)31,32-26(37)24(23)25-33-35-36-34-25)22-15-11-20(12-16-22)10-9-19-5-3-2-4-6-19/h7-8,11-16,19H,2-6,17H2,1H3,(H,32,37)(H,33,34,35,36)
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n/an/a 178n/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in CORNING Falcon 96-well Polypropylene plates, in a total volume of 60 uL of 50 mM Potassium Phosphate buff...


US Patent US9187424 (2015)


BindingDB Entry DOI: 10.7270/Q2FQ9VFG
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM201525
PNG
(US9187424, 292)
Show SMILES CCCCCCCc1cnc(s1)C1(CC(=C(c2nn[nH]n2)C(=O)N1)c1ccc(C)cc1)C(F)(F)F
Show InChI InChI=1S/C24H27F3N6OS/c1-3-4-5-6-7-8-17-14-28-22(35-17)23(24(25,26)27)13-18(16-11-9-15(2)10-12-16)19(21(34)29-23)20-30-32-33-31-20/h9-12,14H,3-8,13H2,1-2H3,(H,29,34)(H,30,31,32,33)
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n/an/a 304n/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in CORNING Falcon 96-well Polypropylene plates, in a total volume of 60 uL of 50 mM Potassium Phosphate buff...


US Patent US9187424 (2015)


BindingDB Entry DOI: 10.7270/Q2FQ9VFG
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM201526
PNG
(US9187424, 293)
Show SMILES CCCCCC#CC1(CC(=C(c2nn[nH]n2)C(=O)N1)c1ccc(C)cc1)C(F)(F)F
Show InChI InChI=1S/C21H22F3N5O/c1-3-4-5-6-7-12-20(21(22,23)24)13-16(15-10-8-14(2)9-11-15)17(19(30)25-20)18-26-28-29-27-18/h8-11H,3-6,13H2,1-2H3,(H,25,30)(H,26,27,28,29)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in CORNING Falcon 96-well Polypropylene plates, in a total volume of 60 uL of 50 mM Potassium Phosphate buff...


US Patent US9187424 (2015)


BindingDB Entry DOI: 10.7270/Q2FQ9VFG
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM201527
PNG
(US9187424, 294)
Show SMILES COc1ccc(cc1)C1=C(c2nn[nH]n2)C(=O)NC(C1)(C#CCCc1ccccc1)C(F)(F)F
Show InChI InChI=1S/C24H20F3N5O2/c1-34-18-12-10-17(11-13-18)19-15-23(24(25,26)27,14-6-5-9-16-7-3-2-4-8-16)28-22(33)20(19)21-29-31-32-30-21/h2-4,7-8,10-13H,5,9,15H2,1H3,(H,28,33)(H,29,30,31,32)
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n/an/a 84n/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in CORNING Falcon 96-well Polypropylene plates, in a total volume of 60 uL of 50 mM Potassium Phosphate buff...


US Patent US9187424 (2015)


BindingDB Entry DOI: 10.7270/Q2FQ9VFG
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM201528
PNG
(US9187424, 295)
Show SMILES COc1ccc(cc1)C1=C(c2nn[nH]n2)C(=O)NC(C1)(C#CCCC(C)C)C(F)(F)F
Show InChI InChI=1S/C21H22F3N5O2/c1-13(2)6-4-5-11-20(21(22,23)24)12-16(14-7-9-15(31-3)10-8-14)17(19(30)25-20)18-26-28-29-27-18/h7-10,13H,4,6,12H2,1-3H3,(H,25,30)(H,26,27,28,29)
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n/an/a 183n/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

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Assay Description
The MGAT enzyme reactions were performed in CORNING Falcon 96-well Polypropylene plates, in a total volume of 60 uL of 50 mM Potassium Phosphate buff...


US Patent US9187424 (2015)


BindingDB Entry DOI: 10.7270/Q2FQ9VFG
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM201529
PNG
(US9187424, 296)
Show SMILES COc1ccc(NC(=O)C2=C(CC(NC2=O)(c2ccc(OCCCC(F)(F)F)cc2)C(F)(F)F)c2ccc(C)cc2F)cc1
Show InChI InChI=1S/C31H27F7N2O4/c1-18-4-13-23(25(32)16-18)24-17-29(31(36,37)38,19-5-9-22(10-6-19)44-15-3-14-30(33,34)35)40-28(42)26(24)27(41)39-20-7-11-21(43-2)12-8-20/h4-13,16H,3,14-15,17H2,1-2H3,(H,39,41)(H,40,42)
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n/an/a 2n/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in CORNING Falcon 96-well Polypropylene plates, in a total volume of 60 uL of 50 mM Potassium Phosphate buff...


US Patent US9187424 (2015)


BindingDB Entry DOI: 10.7270/Q2FQ9VFG
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM201530
PNG
(US9187424, 297)
Show SMILES Cc1ccc(cc1)C1=C(NC(=O)CNS(C)(=O)=O)C(=O)NC(C1)(c1ccc(OCCCC(F)(F)F)cc1)C(F)(F)F
Show InChI InChI=1S/C26H27F6N3O5S/c1-16-4-6-17(7-5-16)20-14-24(26(30,31)32,35-23(37)22(20)34-21(36)15-33-41(2,38)39)18-8-10-19(11-9-18)40-13-3-12-25(27,28)29/h4-11,33H,3,12-15H2,1-2H3,(H,34,36)(H,35,37)
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n/an/a 639n/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in CORNING Falcon 96-well Polypropylene plates, in a total volume of 60 uL of 50 mM Potassium Phosphate buff...


US Patent US9187424 (2015)


BindingDB Entry DOI: 10.7270/Q2FQ9VFG
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM201531
PNG
(US9187424, 298)
Show SMILES CCCCCCC#CC1(CC(=C(NC(=O)CNS(C)(=O)=O)C(=O)N1)c1ccc(C)cc1)C(F)(F)F
Show InChI InChI=1S/C24H30F3N3O4S/c1-4-5-6-7-8-9-14-23(24(25,26)27)15-19(18-12-10-17(2)11-13-18)21(22(32)30-23)29-20(31)16-28-35(3,33)34/h10-13,28H,4-8,15-16H2,1-3H3,(H,29,31)(H,30,32)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in CORNING Falcon 96-well Polypropylene plates, in a total volume of 60 uL of 50 mM Potassium Phosphate buff...


US Patent US9187424 (2015)


BindingDB Entry DOI: 10.7270/Q2FQ9VFG
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM201532
PNG
(US9187424, 299)
Show SMILES Cc1ccc(cc1)C1=C(NC(=O)c2cccnc2)C(=O)NC(C1)(c1ccc(OCCCC(F)(F)F)cc1)C(F)(F)F
Show InChI InChI=1S/C29H25F6N3O3/c1-18-5-7-19(8-6-18)23-16-27(29(33,34)35,21-9-11-22(12-10-21)41-15-3-13-28(30,31)32)38-26(40)24(23)37-25(39)20-4-2-14-36-17-20/h2,4-12,14,17H,3,13,15-16H2,1H3,(H,37,39)(H,38,40)
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n/an/a 11n/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in CORNING Falcon 96-well Polypropylene plates, in a total volume of 60 uL of 50 mM Potassium Phosphate buff...


US Patent US9187424 (2015)


BindingDB Entry DOI: 10.7270/Q2FQ9VFG
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM201533
PNG
(US9187424, 300)
Show SMILES CCCCCCC#CC1(CC(=C(NC(=O)c2cccnc2)C(=O)N1)c1ccc(C)cc1)C(F)(F)F
Show InChI InChI=1S/C27H28F3N3O2/c1-3-4-5-6-7-8-15-26(27(28,29)30)17-22(20-13-11-19(2)12-14-20)23(25(35)33-26)32-24(34)21-10-9-16-31-18-21/h9-14,16,18H,3-7,17H2,1-2H3,(H,32,34)(H,33,35)
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n/an/a 11n/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

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Assay Description
The MGAT enzyme reactions were performed in CORNING Falcon 96-well Polypropylene plates, in a total volume of 60 uL of 50 mM Potassium Phosphate buff...


US Patent US9187424 (2015)


BindingDB Entry DOI: 10.7270/Q2FQ9VFG
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM201534
PNG
(US9187424, 301)
Show SMILES FC(F)Oc1ccc(cc1)C1=C(c2nn[nH]n2)C(=O)NC(C1)(c1ccc(OCCCCCC(F)(F)F)c(F)c1)C(F)(F)F
Show InChI InChI=1S/C26H22F9N5O3/c27-18-12-15(6-9-19(18)42-11-3-1-2-10-25(30,31)32)24(26(33,34)35)13-17(14-4-7-16(8-5-14)43-23(28)29)20(22(41)36-24)21-37-39-40-38-21/h4-9,12,23H,1-3,10-11,13H2,(H,36,41)(H,37,38,39,40)
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n/an/a 19n/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in CORNING Falcon 96-well Polypropylene plates, in a total volume of 60 uL of 50 mM Potassium Phosphate buff...


US Patent US9187424 (2015)


BindingDB Entry DOI: 10.7270/Q2FQ9VFG
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM201535
PNG
(US9187424, 302)
Show SMILES CCCOc1ccc(cc1)C1(CC(=C(NC(=O)CS(C)(=O)=O)C(=O)N1)c1ccc(C)cc1)C(F)(F)F
Show InChI InChI=1S/C25H27F3N2O5S/c1-4-13-35-19-11-9-18(10-12-19)24(25(26,27)28)14-20(17-7-5-16(2)6-8-17)22(23(32)30-24)29-21(31)15-36(3,33)34/h5-12H,4,13-15H2,1-3H3,(H,29,31)(H,30,32)
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n/an/a 105n/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in CORNING Falcon 96-well Polypropylene plates, in a total volume of 60 uL of 50 mM Potassium Phosphate buff...


US Patent US9187424 (2015)


BindingDB Entry DOI: 10.7270/Q2FQ9VFG
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM201536
PNG
(US9187424, 303)
Show SMILES Cc1ccc(cc1)C1=C(c2nn[nH]n2)C(=O)NC(C1)(c1ccc(OCCCCCC(F)(F)F)c(F)c1)C(F)(F)F
Show InChI InChI=1S/C26H24F7N5O2/c1-15-5-7-16(8-6-15)18-14-24(26(31,32)33,34-23(39)21(18)22-35-37-38-36-22)17-9-10-20(19(27)13-17)40-12-4-2-3-11-25(28,29)30/h5-10,13H,2-4,11-12,14H2,1H3,(H,34,39)(H,35,36,37,38)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in CORNING Falcon 96-well Polypropylene plates, in a total volume of 60 uL of 50 mM Potassium Phosphate buff...


US Patent US9187424 (2015)


BindingDB Entry DOI: 10.7270/Q2FQ9VFG
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM201537
PNG
(US9187424, 304 | US9187424, 309)
Show SMILES Fc1cc(ccc1OCCCCCC(F)(F)F)C1(CC(=C(c2nn[nH]n2)C(=O)N1)c1ccc2ccccc2c1)C(F)(F)F
Show InChI InChI=1S/C29H24F7N5O2/c30-22-15-20(10-11-23(22)43-13-5-1-4-12-28(31,32)33)27(29(34,35)36)16-21(24(26(42)37-27)25-38-40-41-39-25)19-9-8-17-6-2-3-7-18(17)14-19/h2-3,6-11,14-15H,1,4-5,12-13,16H2,(H,37,42)(H,38,39,40,41)
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n/an/a 6n/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in CORNING Falcon 96-well Polypropylene plates, in a total volume of 60 uL of 50 mM Potassium Phosphate buff...


US Patent US9187424 (2015)


BindingDB Entry DOI: 10.7270/Q2FQ9VFG
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM201538
PNG
(US9187424, 305)
Show SMILES CCOc1ccc(cc1)C1=C(c2nn[nH]n2)C(=O)NC(C1)(c1ccc(OCCCCCC(F)(F)F)c(F)c1)C(F)(F)F
Show InChI InChI=1S/C27H26F7N5O3/c1-2-41-18-9-6-16(7-10-18)19-15-25(27(32,33)34,35-24(40)22(19)23-36-38-39-37-23)17-8-11-21(20(28)14-17)42-13-5-3-4-12-26(29,30)31/h6-11,14H,2-5,12-13,15H2,1H3,(H,35,40)(H,36,37,38,39)
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n/an/a 94n/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in CORNING Falcon 96-well Polypropylene plates, in a total volume of 60 uL of 50 mM Potassium Phosphate buff...


US Patent US9187424 (2015)


BindingDB Entry DOI: 10.7270/Q2FQ9VFG
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM201539
PNG
(US9187424, 306)
Show SMILES Fc1cc(ccc1OCCCCCC(F)(F)F)C1(CC(=C(c2nn[nH]n2)C(=O)N1)c1ccc(CC(F)(F)F)cc1)C(F)(F)F
Show InChI InChI=1S/C27H23F10N5O2/c28-19-12-17(8-9-20(19)44-11-3-1-2-10-25(29,30)31)24(27(35,36)37)14-18(21(23(43)38-24)22-39-41-42-40-22)16-6-4-15(5-7-16)13-26(32,33)34/h4-9,12H,1-3,10-11,13-14H2,(H,38,43)(H,39,40,41,42)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in CORNING Falcon 96-well Polypropylene plates, in a total volume of 60 uL of 50 mM Potassium Phosphate buff...


US Patent US9187424 (2015)


BindingDB Entry DOI: 10.7270/Q2FQ9VFG
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM201540
PNG
(US9187424, 307)
Show SMILES CCCCCCC#Cc1ccc(cc1F)C1(CC(=C(c2nn[nH]n2)C(=O)N1)c1ccc(OC(F)F)cc1)C(F)(F)F
Show InChI InChI=1S/C28H25F6N5O2/c1-2-3-4-5-6-7-8-18-9-12-19(15-22(18)29)27(28(32,33)34)16-21(17-10-13-20(14-11-17)41-26(30)31)23(25(40)35-27)24-36-38-39-37-24/h9-15,26H,2-6,16H2,1H3,(H,35,40)(H,36,37,38,39)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in CORNING Falcon 96-well Polypropylene plates, in a total volume of 60 uL of 50 mM Potassium Phosphate buff...


US Patent US9187424 (2015)


BindingDB Entry DOI: 10.7270/Q2FQ9VFG
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM201541
PNG
(US9187424, 308)
Show SMILES CCCCCCC#Cc1ccc(cc1F)C1(CC(=C(c2nn[nH]n2)C(=O)N1)c1ccc(OCC)cc1)C(F)(F)F
Show InChI InChI=1S/C29H29F4N5O2/c1-3-5-6-7-8-9-10-20-11-14-21(17-24(20)30)28(29(31,32)33)18-23(19-12-15-22(16-13-19)40-4-2)25(27(39)34-28)26-35-37-38-36-26/h11-17H,3-8,18H2,1-2H3,(H,34,39)(H,35,36,37,38)
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n/an/a 61n/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in CORNING Falcon 96-well Polypropylene plates, in a total volume of 60 uL of 50 mM Potassium Phosphate buff...


US Patent US9187424 (2015)


BindingDB Entry DOI: 10.7270/Q2FQ9VFG
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM201537
PNG
(US9187424, 304 | US9187424, 309)
Show SMILES Fc1cc(ccc1OCCCCCC(F)(F)F)C1(CC(=C(c2nn[nH]n2)C(=O)N1)c1ccc2ccccc2c1)C(F)(F)F
Show InChI InChI=1S/C29H24F7N5O2/c30-22-15-20(10-11-23(22)43-13-5-1-4-12-28(31,32)33)27(29(34,35)36)16-21(24(26(42)37-27)25-38-40-41-39-25)19-9-8-17-6-2-3-7-18(17)14-19/h2-3,6-11,14-15H,1,4-5,12-13,16H2,(H,37,42)(H,38,39,40,41)
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n/an/a 1n/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in CORNING Falcon 96-well Polypropylene plates, in a total volume of 60 uL of 50 mM Potassium Phosphate buff...


US Patent US9187424 (2015)


BindingDB Entry DOI: 10.7270/Q2FQ9VFG
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM201543
PNG
(US9187424, 310)
Show SMILES Cc1ccc(cc1)C1=C(NC(=O)c2nnn[nH]2)C(=O)NC(C1)(c1ccc(OCCCC(F)(F)F)cc1)C(F)(F)F
Show InChI InChI=1S/C25H22F6N6O3/c1-14-3-5-15(6-4-14)18-13-23(25(29,30)31,33-21(38)19(18)32-22(39)20-34-36-37-35-20)16-7-9-17(10-8-16)40-12-2-11-24(26,27)28/h3-10H,2,11-13H2,1H3,(H,32,39)(H,33,38)(H,34,35,36,37)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in CORNING Falcon 96-well Polypropylene plates, in a total volume of 60 uL of 50 mM Potassium Phosphate buff...


US Patent US9187424 (2015)


BindingDB Entry DOI: 10.7270/Q2FQ9VFG
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM201544
PNG
(US9187424, 311)
Show SMILES CCCCCCCC#CC1(CC(=C(NC(=O)c2nnn[nH]2)C(=O)N1)c1ccc(C)cc1)C(F)(F)F
Show InChI InChI=1S/C24H27F3N6O2/c1-3-4-5-6-7-8-9-14-23(24(25,26)27)15-18(17-12-10-16(2)11-13-17)19(21(34)29-23)28-22(35)20-30-32-33-31-20/h10-13H,3-8,15H2,1-2H3,(H,28,35)(H,29,34)(H,30,31,32,33)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in CORNING Falcon 96-well Polypropylene plates, in a total volume of 60 uL of 50 mM Potassium Phosphate buff...


US Patent US9187424 (2015)


BindingDB Entry DOI: 10.7270/Q2FQ9VFG
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM201545
PNG
(US9187424, 312)
Show SMILES CCCCCCCC#CC1(CC(=C(NC(=O)CS(C)(=O)=O)C(=O)N1)c1ccc(OCC)cc1)C(F)(F)F
Show InChI InChI=1S/C26H33F3N2O5S/c1-4-6-7-8-9-10-11-16-25(26(27,28)29)17-21(19-12-14-20(15-13-19)36-5-2)23(24(33)31-25)30-22(32)18-37(3,34)35/h12-15H,4-10,17-18H2,1-3H3,(H,30,32)(H,31,33)
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n/an/a 21n/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in CORNING Falcon 96-well Polypropylene plates, in a total volume of 60 uL of 50 mM Potassium Phosphate buff...


US Patent US9187424 (2015)


BindingDB Entry DOI: 10.7270/Q2FQ9VFG
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM201546
PNG
(US9187424, 313)
Show SMILES CCCCCCCC#CC1(CC(=C(NC(=O)CS(C)(=O)=O)C(=O)N1)c1ccc(OC(F)F)cc1)C(F)(F)F
Show InChI InChI=1S/C25H29F5N2O5S/c1-3-4-5-6-7-8-9-14-24(25(28,29)30)15-19(17-10-12-18(13-11-17)37-23(26)27)21(22(34)32-24)31-20(33)16-38(2,35)36/h10-13,23H,3-8,15-16H2,1-2H3,(H,31,33)(H,32,34)
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n/an/a 4n/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in CORNING Falcon 96-well Polypropylene plates, in a total volume of 60 uL of 50 mM Potassium Phosphate buff...


US Patent US9187424 (2015)


BindingDB Entry DOI: 10.7270/Q2FQ9VFG
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM201547
PNG
(US9187424, 314)
Show SMILES Cc1ccc(cc1)C1=C(c2nn[nH]n2)C(=O)NC(C1)(c1ccc(OCCCC(F)(F)F)c(C)c1)C(F)(F)F
Show InChI InChI=1S/C25H23F6N5O2/c1-14-4-6-16(7-5-14)18-13-23(25(29,30)31,32-22(37)20(18)21-33-35-36-34-21)17-8-9-19(15(2)12-17)38-11-3-10-24(26,27)28/h4-9,12H,3,10-11,13H2,1-2H3,(H,32,37)(H,33,34,35,36)
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n/an/a 109n/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in CORNING Falcon 96-well Polypropylene plates, in a total volume of 60 uL of 50 mM Potassium Phosphate buff...


US Patent US9187424 (2015)


BindingDB Entry DOI: 10.7270/Q2FQ9VFG
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM201232
PNG
(US9187424, 2 | US9187424, 2-1)
Show SMILES Cc1ccc(cc1)C1=C(c2nnn[nH]2)C(=O)NC(C1)(c1ccc(OCCCC(F)(F)F)cc1)C(F)(F)F
Show InChI InChI=1S/C24H21F6N5O2/c1-14-3-5-15(6-4-14)18-13-22(24(28,29)30,31-21(36)19(18)20-32-34-35-33-20)16-7-9-17(10-8-16)37-12-2-11-23(25,26)27/h3-10H,2,11-13H2,1H3,(H,31,36)(H,32,33,34,35)
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n/an/a 85n/an/an/an/a7.425



Bristol-Myers Squibb Company

US Patent


Assay Description
MGAT2 enzyme was assayed using membranes isolated from Sf9 cells expressing the recombinant human MGAT2 cDNA with 2-monooleoylglycerol and [3H]-oleoy...


US Patent US9187424 (2015)


BindingDB Entry DOI: 10.7270/Q2FQ9VFG
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM201232
PNG
(US9187424, 2 | US9187424, 2-1)
Show SMILES Cc1ccc(cc1)C1=C(c2nnn[nH]2)C(=O)NC(C1)(c1ccc(OCCCC(F)(F)F)cc1)C(F)(F)F
Show InChI InChI=1S/C24H21F6N5O2/c1-14-3-5-15(6-4-14)18-13-22(24(28,29)30,31-21(36)19(18)20-32-34-35-33-20)16-7-9-17(10-8-16)37-12-2-11-23(25,26)27/h3-10H,2,11-13H2,1H3,(H,31,36)(H,32,33,34,35)
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n/an/a 35n/an/an/an/a7.425



Bristol-Myers Squibb Company

US Patent


Assay Description
MGAT2 enzyme was assayed using membranes isolated from Sf9 cells expressing the recombinant human MGAT2 cDNA with 2-monooleoylglycerol and [3H]-oleoy...


US Patent US9187424 (2015)


BindingDB Entry DOI: 10.7270/Q2FQ9VFG
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM201234
PNG
(US9187424, 2-2)
Show SMILES Cc1ccc(cc1)C1=C(c2nnn[nH]2)C(=O)N[C@](C1)(c1ccc(OCCCC(F)(F)F)cc1)C(F)(F)F
Show InChI InChI=1S/C24H21F6N5O2/c1-14-3-5-15(6-4-14)18-13-22(24(28,29)30,31-21(36)19(18)20-32-34-35-33-20)16-7-9-17(10-8-16)37-12-2-11-23(25,26)27/h3-10H,2,11-13H2,1H3,(H,31,36)(H,32,33,34,35)/t22-/m1/s1
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n/an/a 1.40E+3n/an/an/an/a7.425



Bristol-Myers Squibb Company

US Patent


Assay Description
MGAT2 enzyme was assayed using membranes isolated from Sf9 cells expressing the recombinant human MGAT2 cDNA with 2-monooleoylglycerol and [3H]-oleoy...


US Patent US9187424 (2015)


BindingDB Entry DOI: 10.7270/Q2FQ9VFG
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM201235
PNG
(US9187424, 3)
Show SMILES Cc1ccc(cc1)C1=C(C#N)C(=O)NC(C)(C1)c1ccc(Br)cc1
Show InChI InChI=1S/C20H17BrN2O/c1-13-3-5-14(6-4-13)17-11-20(2,23-19(24)18(17)12-22)15-7-9-16(21)10-8-15/h3-10H,11H2,1-2H3,(H,23,24)
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n/an/a 1.80E+3n/an/an/an/a7.425



Bristol-Myers Squibb Company

US Patent


Assay Description
MGAT2 enzyme was assayed using membranes isolated from Sf9 cells expressing the recombinant human MGAT2 cDNA with 2-monooleoylglycerol and [3H]-oleoy...


US Patent US9187424 (2015)


BindingDB Entry DOI: 10.7270/Q2FQ9VFG
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM201237
PNG
(US9187424, 5)
Show SMILES CCCCOc1ccc(cc1)C1(CC(=C(C#N)C(=O)N1)c1ccc(C)cc1)C(F)(F)F
Show InChI InChI=1S/C24H23F3N2O2/c1-3-4-13-31-19-11-9-18(10-12-19)23(24(25,26)27)14-20(21(15-28)22(30)29-23)17-7-5-16(2)6-8-17/h5-12H,3-4,13-14H2,1-2H3,(H,29,30)
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Bristol-Myers Squibb Company

US Patent


Assay Description
MGAT2 enzyme was assayed using membranes isolated from Sf9 cells expressing the recombinant human MGAT2 cDNA with 2-monooleoylglycerol and [3H]-oleoy...


US Patent US9187424 (2015)


BindingDB Entry DOI: 10.7270/Q2FQ9VFG
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM50442178
PNG
(CHEMBL2441600 | US9187424, 124)
Show SMILES COc1ccc(NC(=O)C2=C(CC(NC2=O)(c2ccc(OCCCC(F)(F)F)cc2)C(F)(F)F)c2ccc(C)cc2)cc1
Show InChI InChI=1S/C31H28F6N2O4/c1-19-4-6-20(7-5-19)25-18-29(31(35,36)37,21-8-12-24(13-9-21)43-17-3-16-30(32,33)34)39-28(41)26(25)27(40)38-22-10-14-23(42-2)15-11-22/h4-15H,3,16-18H2,1-2H3,(H,38,40)(H,39,41)
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n/an/a 15n/an/an/an/a7.425



Bristol-Myers Squibb Company

US Patent


Assay Description
MGAT2 enzyme was assayed using membranes isolated from Sf9 cells expressing the recombinant human MGAT2 cDNA with 2-monooleoylglycerol and [3H]-oleoy...


US Patent US9187424 (2015)


BindingDB Entry DOI: 10.7270/Q2FQ9VFG
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM201238
PNG
(US9187424, 6-1)
Show SMILES COc1ccc(NC(=O)C2=C(C[C@@](NC2=O)(c2ccc(OCCCC(F)(F)F)cc2)C(F)(F)F)c2ccc(C)cc2)cc1
Show InChI InChI=1S/C31H28F6N2O4/c1-19-4-6-20(7-5-19)25-18-29(31(35,36)37,21-8-12-24(13-9-21)43-17-3-16-30(32,33)34)39-28(41)26(25)27(40)38-22-10-14-23(42-2)15-11-22/h4-15H,3,16-18H2,1-2H3,(H,38,40)(H,39,41)/t29-/m1/s1
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n/an/a 1.44E+3n/an/an/an/a7.425



Bristol-Myers Squibb Company

US Patent


Assay Description
MGAT2 enzyme was assayed using membranes isolated from Sf9 cells expressing the recombinant human MGAT2 cDNA with 2-monooleoylglycerol and [3H]-oleoy...


US Patent US9187424 (2015)


BindingDB Entry DOI: 10.7270/Q2FQ9VFG
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM201239
PNG
(US9187424, 6-2)
Show SMILES COc1ccc(NC(=O)C2=C(C[C@](NC2=O)(c2ccc(OCCCC(F)(F)F)cc2)C(F)(F)F)c2ccc(C)cc2)cc1
Show InChI InChI=1S/C31H28F6N2O4/c1-19-4-6-20(7-5-19)25-18-29(31(35,36)37,21-8-12-24(13-9-21)43-17-3-16-30(32,33)34)39-28(41)26(25)27(40)38-22-10-14-23(42-2)15-11-22/h4-15H,3,16-18H2,1-2H3,(H,38,40)(H,39,41)/t29-/m0/s1
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n/an/a 14n/an/an/an/a7.425



Bristol-Myers Squibb Company

US Patent


Assay Description
MGAT2 enzyme was assayed using membranes isolated from Sf9 cells expressing the recombinant human MGAT2 cDNA with 2-monooleoylglycerol and [3H]-oleoy...


US Patent US9187424 (2015)


BindingDB Entry DOI: 10.7270/Q2FQ9VFG
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM201240
PNG
(US9187424, 7)
Show SMILES CCOc1ccc(cn1)-c1ccc(cc1)C1(CC(=C(C#N)C(=O)N1)c1ccc(C)cc1)C(F)(F)F
Show InChI InChI=1S/C27H22F3N3O2/c1-3-35-24-13-10-20(16-32-24)18-8-11-21(12-9-18)26(27(28,29)30)14-22(23(15-31)25(34)33-26)19-6-4-17(2)5-7-19/h4-13,16H,3,14H2,1-2H3,(H,33,34)
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Bristol-Myers Squibb Company

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Assay Description
MGAT2 enzyme was assayed using membranes isolated from Sf9 cells expressing the recombinant human MGAT2 cDNA with 2-monooleoylglycerol and [3H]-oleoy...


US Patent US9187424 (2015)


BindingDB Entry DOI: 10.7270/Q2FQ9VFG
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM201242
PNG
(US9187424, 10)
Show SMILES Cc1ccc(cc1)C1=C(c2nnc(o2)C(F)(F)F)C(=O)NC(C1)(c1ccc(OCCCC(F)(F)F)cc1)C(F)(F)F
Show InChI InChI=1S/C26H20F9N3O3/c1-14-3-5-15(6-4-14)18-13-23(26(33,34)35,16-7-9-17(10-8-16)40-12-2-11-24(27,28)29)36-20(39)19(18)21-37-38-22(41-21)25(30,31)32/h3-10H,2,11-13H2,1H3,(H,36,39)
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n/an/a 2.72E+3n/an/an/an/a7.425



Bristol-Myers Squibb Company

US Patent


Assay Description
MGAT2 enzyme was assayed using membranes isolated from Sf9 cells expressing the recombinant human MGAT2 cDNA with 2-monooleoylglycerol and [3H]-oleoy...


US Patent US9187424 (2015)


BindingDB Entry DOI: 10.7270/Q2FQ9VFG
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM201243
PNG
(US9187424, 11)
Show SMILES Cc1ccc(cc1)C1=C(C(=O)Nc2ccc(OC(F)(F)F)cc2)C(=O)NC(C)(C1)c1ccc(OCCCC(F)(F)F)cc1
Show InChI InChI=1S/C31H28F6N2O4/c1-19-4-6-20(7-5-19)25-18-29(2,21-8-12-23(13-9-21)42-17-3-16-30(32,33)34)39-28(41)26(25)27(40)38-22-10-14-24(15-11-22)43-31(35,36)37/h4-15H,3,16-18H2,1-2H3,(H,38,40)(H,39,41)
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Bristol-Myers Squibb Company

US Patent


Assay Description
MGAT2 enzyme was assayed using membranes isolated from Sf9 cells expressing the recombinant human MGAT2 cDNA with 2-monooleoylglycerol and [3H]-oleoy...


US Patent US9187424 (2015)


BindingDB Entry DOI: 10.7270/Q2FQ9VFG
More data for this
Ligand-Target Pair
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