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Compile Data Set for Download or QSAR

Found 175 hits Enz. Inhib. hit(s) with Target = 'Alpha-mannosidase'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Golgi alpha-mannosidase II


(Homo sapiens (Human))
BDBM84465
PNG
(Benzylation of mannostatin A, 1e)
Show SMILES CS[C@H]1[C@H](O)[C@H](O)[C@H](O)[C@@H]1NCc1ccc(Br)cc1
Show InChI InChI=1S/C13H18BrNO3S/c1-19-13-9(10(16)11(17)12(13)18)15-6-7-2-4-8(14)5-3-7/h2-5,9-13,15-18H,6H2,1H3/t9-,10+,11+,12+,13+/m0/s1
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50 -43.3n/an/an/an/an/a5.637



University of Georgia





Chembiochem 5: 1220-7 (2004)


Article DOI: 10.1002/cbic.200300842
BindingDB Entry DOI: 10.7270/Q2ZW1JF3
More data for this
Ligand-Target Pair
Golgi alpha-mannosidase II


(Homo sapiens (Human))
BDBM50078117
PNG
((1R,2R,3R,4S,5R)-4-AMINO-5-(METHYLTHIO)CYCLOPENTAN...)
Show SMILES CS[C@@H]1[C@@H](N)[C@@H](O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C6H13NO3S/c1-11-6-2(7)3(8)4(9)5(6)10/h2-6,8-10H,7H2,1H3/t2-,3+,4+,5+,6+/m0/s1
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90 -41.8n/an/an/an/an/a5.637



University of Georgia





Chembiochem 5: 1220-7 (2004)


Article DOI: 10.1002/cbic.200300842
BindingDB Entry DOI: 10.7270/Q2ZW1JF3
More data for this
Ligand-Target Pair
Golgi alpha-mannosidase II


(Homo sapiens (Human))
BDBM84464
PNG
(Benzylation of mannostatin A, 1d)
Show SMILES CS[C@H]1[C@H](O)[C@H](O)[C@H](O)[C@@H]1NCc1ccc(Cl)cc1
Show InChI InChI=1S/C13H18ClNO3S/c1-19-13-9(10(16)11(17)12(13)18)15-6-7-2-4-8(14)5-3-7/h2-5,9-13,15-18H,6H2,1H3/t9-,10+,11+,12+,13+/m0/s1
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100 -41.6n/an/an/an/an/a5.637



University of Georgia





Chembiochem 5: 1220-7 (2004)


Article DOI: 10.1002/cbic.200300842
BindingDB Entry DOI: 10.7270/Q2ZW1JF3
More data for this
Ligand-Target Pair
Golgi alpha-mannosidase II


(Homo sapiens (Human))
BDBM84466
PNG
(Benzylation of mannostatin A, 1f)
Show SMILES COc1ccc(CN[C@H]2[C@@H](O)[C@@H](O)[C@@H](O)[C@@H]2SC)cc1
Show InChI InChI=1S/C14H21NO4S/c1-19-9-5-3-8(4-6-9)7-15-10-11(16)12(17)13(18)14(10)20-2/h3-6,10-18H,7H2,1-2H3/t10-,11+,12+,13+,14+/m0/s1
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100 -41.6n/an/an/an/an/a5.637



University of Georgia





Chembiochem 5: 1220-7 (2004)


Article DOI: 10.1002/cbic.200300842
BindingDB Entry DOI: 10.7270/Q2ZW1JF3
More data for this
Ligand-Target Pair
Golgi alpha-mannosidase II


(Homo sapiens (Human))
BDBM84462
PNG
(Benzylation of mannostatin A, 1b)
Show SMILES CS[C@H]1[C@H](O)[C@H](O)[C@H](O)[C@@H]1NCc1ccccc1
Show InChI InChI=1S/C13H19NO3S/c1-18-13-9(10(15)11(16)12(13)17)14-7-8-5-3-2-4-6-8/h2-6,9-17H,7H2,1H3/t9-,10+,11+,12+,13+/m0/s1
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110 -41.3n/an/an/an/an/a5.637



University of Georgia





Chembiochem 5: 1220-7 (2004)


Article DOI: 10.1002/cbic.200300842
BindingDB Entry DOI: 10.7270/Q2ZW1JF3
More data for this
Ligand-Target Pair
Golgi alpha-mannosidase II


(Homo sapiens (Human))
BDBM84467
PNG
(Benzylation of mannostatin A, 1g)
Show SMILES CS[C@H]1[C@H](O)[C@H](O)[C@H](O)[C@@H]1NCc1ccc(cc1)C(=O)OCC=C
Show InChI InChI=1S/C17H23NO5S/c1-3-8-23-17(22)11-6-4-10(5-7-11)9-18-12-13(19)14(20)15(21)16(12)24-2/h3-7,12-16,18-21H,1,8-9H2,2H3/t12-,13+,14+,15+,16+/m0/s1
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140 -40.7n/an/an/an/an/a5.637



University of Georgia





Chembiochem 5: 1220-7 (2004)


Article DOI: 10.1002/cbic.200300842
BindingDB Entry DOI: 10.7270/Q2ZW1JF3
More data for this
Ligand-Target Pair
Golgi alpha-mannosidase II


(Homo sapiens (Human))
BDBM84474
PNG
(Aminocyclopentitetrol, 2g)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O)[C@@H](NCc2ccc(cc2)C(=O)OCC=C)[C@H]1O
Show InChI InChI=1S/C16H21NO6/c1-2-7-23-16(22)10-5-3-9(4-6-10)8-17-11-12(18)14(20)15(21)13(11)19/h2-6,11-15,17-21H,1,7-8H2/t11-,12+,13-,14+,15-
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160 -40.3n/an/an/an/an/a5.637



University of Georgia





Chembiochem 5: 1220-7 (2004)


Article DOI: 10.1002/cbic.200300842
BindingDB Entry DOI: 10.7270/Q2ZW1JF3
More data for this
Ligand-Target Pair
Golgi alpha-mannosidase II


(Homo sapiens (Human))
BDBM84463
PNG
(Benzylation of mannostatin A, 1c)
Show SMILES CS[C@H]1[C@H](O)[C@H](O)[C@H](O)[C@@H]1NCc1ccc(F)cc1
Show InChI InChI=1S/C13H18FNO3S/c1-19-13-9(10(16)11(17)12(13)18)15-6-7-2-4-8(14)5-3-7/h2-5,9-13,15-18H,6H2,1H3/t9-,10+,11+,12+,13+/m0/s1
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170 -40.2n/an/an/an/an/a5.637



University of Georgia





Chembiochem 5: 1220-7 (2004)


Article DOI: 10.1002/cbic.200300842
BindingDB Entry DOI: 10.7270/Q2ZW1JF3
More data for this
Ligand-Target Pair
Golgi alpha-mannosidase II


(Homo sapiens (Human))
BDBM50078117
PNG
((1R,2R,3R,4S,5R)-4-AMINO-5-(METHYLTHIO)CYCLOPENTAN...)
Show SMILES CS[C@@H]1[C@@H](N)[C@@H](O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C6H13NO3S/c1-11-6-2(7)3(8)4(9)5(6)10/h2-6,8-10H,7H2,1H3/t2-,3+,4+,5+,6+/m0/s1
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210 -39.6n/an/an/an/an/a5.637



University of Georgia





Chembiochem 5: 1220-7 (2004)


Article DOI: 10.1002/cbic.200300842
BindingDB Entry DOI: 10.7270/Q2ZW1JF3
More data for this
Ligand-Target Pair
Golgi alpha-mannosidase II


(Homo sapiens (Human))
BDBM84470
PNG
(Aminocyclopentitetrol, 2c)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O)[C@@H](NCc2ccc(F)cc2)[C@H]1O
Show InChI InChI=1S/C12H16FNO4/c13-7-3-1-6(2-4-7)5-14-8-9(15)11(17)12(18)10(8)16/h1-4,8-12,14-18H,5H2/t8-,9+,10-,11+,12-
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330 -38.5n/an/an/an/an/a5.637



University of Georgia





Chembiochem 5: 1220-7 (2004)


Article DOI: 10.1002/cbic.200300842
BindingDB Entry DOI: 10.7270/Q2ZW1JF3
More data for this
Ligand-Target Pair
Golgi alpha-mannosidase II


(Homo sapiens (Human))
BDBM84472
PNG
(Aminocyclopentitetrol, 2e)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O)[C@@H](NCc2ccc(Br)cc2)[C@H]1O
Show InChI InChI=1S/C12H16BrNO4/c13-7-3-1-6(2-4-7)5-14-8-9(15)11(17)12(18)10(8)16/h1-4,8-12,14-18H,5H2/t8-,9+,10-,11+,12-
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330 -38.5n/an/an/an/an/a5.637



University of Georgia





Chembiochem 5: 1220-7 (2004)


Article DOI: 10.1002/cbic.200300842
BindingDB Entry DOI: 10.7270/Q2ZW1JF3
More data for this
Ligand-Target Pair
Golgi alpha-mannosidase II


(Homo sapiens (Human))
BDBM84469
PNG
(Aminocyclopentitetrol, 2b)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O)[C@@H](NCc2ccccc2)[C@H]1O
Show InChI InChI=1S/C12H17NO4/c14-9-8(10(15)12(17)11(9)16)13-6-7-4-2-1-3-5-7/h1-5,8-17H,6H2/t8-,9+,10-,11+,12-
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450 -37.7n/an/an/an/an/a5.637



University of Georgia





Chembiochem 5: 1220-7 (2004)


Article DOI: 10.1002/cbic.200300842
BindingDB Entry DOI: 10.7270/Q2ZW1JF3
More data for this
Ligand-Target Pair
Golgi alpha-mannosidase II


(Homo sapiens (Human))
BDBM84473
PNG
(Aminocyclopentitetrol, 2f)
Show SMILES COc1ccc(CN[C@H]2[C@@H](O)[C@@H](O)[C@@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C13H19NO5/c1-19-8-4-2-7(3-5-8)6-14-9-10(15)12(17)13(18)11(9)16/h2-5,9-18H,6H2,1H3/t9-,10+,11-,12+,13-
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480 -37.5n/an/an/an/an/a5.637



University of Georgia





Chembiochem 5: 1220-7 (2004)


Article DOI: 10.1002/cbic.200300842
BindingDB Entry DOI: 10.7270/Q2ZW1JF3
More data for this
Ligand-Target Pair
Golgi alpha-mannosidase II


(Homo sapiens (Human))
BDBM84465
PNG
(Benzylation of mannostatin A, 1e)
Show SMILES CS[C@H]1[C@H](O)[C@H](O)[C@H](O)[C@@H]1NCc1ccc(Br)cc1
Show InChI InChI=1S/C13H18BrNO3S/c1-19-13-9(10(16)11(17)12(13)18)15-6-7-2-4-8(14)5-3-7/h2-5,9-13,15-18H,6H2,1H3/t9-,10+,11+,12+,13+/m0/s1
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510 -37.4n/an/an/an/an/a5.637



University of Georgia





Chembiochem 5: 1220-7 (2004)


Article DOI: 10.1002/cbic.200300842
BindingDB Entry DOI: 10.7270/Q2ZW1JF3
More data for this
Ligand-Target Pair
Golgi alpha-mannosidase II


(Homo sapiens (Human))
BDBM84466
PNG
(Benzylation of mannostatin A, 1f)
Show SMILES COc1ccc(CN[C@H]2[C@@H](O)[C@@H](O)[C@@H](O)[C@@H]2SC)cc1
Show InChI InChI=1S/C14H21NO4S/c1-19-9-5-3-8(4-6-9)7-15-10-11(16)12(17)13(18)14(10)20-2/h3-6,10-18H,7H2,1-2H3/t10-,11+,12+,13+,14+/m0/s1
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520 -37.3n/an/an/an/an/a5.637



University of Georgia





Chembiochem 5: 1220-7 (2004)


Article DOI: 10.1002/cbic.200300842
BindingDB Entry DOI: 10.7270/Q2ZW1JF3
More data for this
Ligand-Target Pair
Golgi alpha-mannosidase II


(Homo sapiens (Human))
BDBM84463
PNG
(Benzylation of mannostatin A, 1c)
Show SMILES CS[C@H]1[C@H](O)[C@H](O)[C@H](O)[C@@H]1NCc1ccc(F)cc1
Show InChI InChI=1S/C13H18FNO3S/c1-19-13-9(10(16)11(17)12(13)18)15-6-7-2-4-8(14)5-3-7/h2-5,9-13,15-18H,6H2,1H3/t9-,10+,11+,12+,13+/m0/s1
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530 -37.3n/an/an/an/an/a5.637



University of Georgia





Chembiochem 5: 1220-7 (2004)


Article DOI: 10.1002/cbic.200300842
BindingDB Entry DOI: 10.7270/Q2ZW1JF3
More data for this
Ligand-Target Pair
Golgi alpha-mannosidase II


(Homo sapiens (Human))
BDBM84471
PNG
(Aminocyclopentitetrol, 2d)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O)[C@@H](NCc2ccc(Cl)cc2)[C@H]1O
Show InChI InChI=1S/C12H16ClNO4/c13-7-3-1-6(2-4-7)5-14-8-9(15)11(17)12(18)10(8)16/h1-4,8-12,14-18H,5H2/t8-,9+,10-,11+,12-
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670 -36.7n/an/an/an/an/a5.637



University of Georgia





Chembiochem 5: 1220-7 (2004)


Article DOI: 10.1002/cbic.200300842
BindingDB Entry DOI: 10.7270/Q2ZW1JF3
More data for this
Ligand-Target Pair
Golgi alpha-mannosidase II


(Homo sapiens (Human))
BDBM84462
PNG
(Benzylation of mannostatin A, 1b)
Show SMILES CS[C@H]1[C@H](O)[C@H](O)[C@H](O)[C@@H]1NCc1ccccc1
Show InChI InChI=1S/C13H19NO3S/c1-18-13-9(10(15)11(16)12(13)17)14-7-8-5-3-2-4-6-8/h2-6,9-17H,7H2,1H3/t9-,10+,11+,12+,13+/m0/s1
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880 -36.0n/an/an/an/an/a5.637



University of Georgia





Chembiochem 5: 1220-7 (2004)


Article DOI: 10.1002/cbic.200300842
BindingDB Entry DOI: 10.7270/Q2ZW1JF3
More data for this
Ligand-Target Pair
Golgi alpha-mannosidase II


(Homo sapiens (Human))
BDBM84464
PNG
(Benzylation of mannostatin A, 1d)
Show SMILES CS[C@H]1[C@H](O)[C@H](O)[C@H](O)[C@@H]1NCc1ccc(Cl)cc1
Show InChI InChI=1S/C13H18ClNO3S/c1-19-13-9(10(16)11(17)12(13)18)15-6-7-2-4-8(14)5-3-7/h2-5,9-13,15-18H,6H2,1H3/t9-,10+,11+,12+,13+/m0/s1
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910 -35.9n/an/an/an/an/a5.637



University of Georgia





Chembiochem 5: 1220-7 (2004)


Article DOI: 10.1002/cbic.200300842
BindingDB Entry DOI: 10.7270/Q2ZW1JF3
More data for this
Ligand-Target Pair
Golgi alpha-mannosidase II


(Homo sapiens (Human))
BDBM84467
PNG
(Benzylation of mannostatin A, 1g)
Show SMILES CS[C@H]1[C@H](O)[C@H](O)[C@H](O)[C@@H]1NCc1ccc(cc1)C(=O)OCC=C
Show InChI InChI=1S/C17H23NO5S/c1-3-8-23-17(22)11-6-4-10(5-7-11)9-18-12-13(19)14(20)15(21)16(12)24-2/h3-7,12-16,18-21H,1,8-9H2,2H3/t12-,13+,14+,15+,16+/m0/s1
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3.22E+3 -32.6n/an/an/an/an/a5.637



University of Georgia





Chembiochem 5: 1220-7 (2004)


Article DOI: 10.1002/cbic.200300842
BindingDB Entry DOI: 10.7270/Q2ZW1JF3
More data for this
Ligand-Target Pair
Golgi alpha-mannosidase II


(Homo sapiens (Human))
BDBM84474
PNG
(Aminocyclopentitetrol, 2g)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O)[C@@H](NCc2ccc(cc2)C(=O)OCC=C)[C@H]1O
Show InChI InChI=1S/C16H21NO6/c1-2-7-23-16(22)10-5-3-9(4-6-10)8-17-11-12(18)14(20)15(21)13(11)19/h2-6,11-15,17-21H,1,7-8H2/t11-,12+,13-,14+,15-
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4.40E+3 -31.8n/an/an/an/an/a5.637



University of Georgia





Chembiochem 5: 1220-7 (2004)


Article DOI: 10.1002/cbic.200300842
BindingDB Entry DOI: 10.7270/Q2ZW1JF3
More data for this
Ligand-Target Pair
Golgi alpha-mannosidase II


(Homo sapiens (Human))
BDBM84470
PNG
(Aminocyclopentitetrol, 2c)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O)[C@@H](NCc2ccc(F)cc2)[C@H]1O
Show InChI InChI=1S/C12H16FNO4/c13-7-3-1-6(2-4-7)5-14-8-9(15)11(17)12(18)10(8)16/h1-4,8-12,14-18H,5H2/t8-,9+,10-,11+,12-
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6.00E+3 -31.0n/an/an/an/an/a5.637



University of Georgia





Chembiochem 5: 1220-7 (2004)


Article DOI: 10.1002/cbic.200300842
BindingDB Entry DOI: 10.7270/Q2ZW1JF3
More data for this
Ligand-Target Pair
Golgi alpha-mannosidase II


(Homo sapiens (Human))
BDBM84473
PNG
(Aminocyclopentitetrol, 2f)
Show SMILES COc1ccc(CN[C@H]2[C@@H](O)[C@@H](O)[C@@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C13H19NO5/c1-19-8-4-2-7(3-5-8)6-14-9-10(15)12(17)13(18)11(9)16/h2-5,9-18H,6H2,1H3/t9-,10+,11-,12+,13-
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6.60E+3 -30.8n/an/an/an/an/a5.637



University of Georgia





Chembiochem 5: 1220-7 (2004)


Article DOI: 10.1002/cbic.200300842
BindingDB Entry DOI: 10.7270/Q2ZW1JF3
More data for this
Ligand-Target Pair
Golgi alpha-mannosidase II


(Homo sapiens (Human))
BDBM84468
PNG
(Mannostatin analogue, 4b | Meso-aminocyclopentitet...)
Show SMILES N[C@@H]1[C@H](O)[C@H](O)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C5H11NO4/c6-1-2(7)4(9)5(10)3(1)8/h1-5,7-10H,6H2/t1-,2+,3-,4+,5-
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6.60E+3 -30.8n/an/an/an/an/a5.637



University of Georgia





Chembiochem 5: 1220-7 (2004)


Article DOI: 10.1002/cbic.200300842
BindingDB Entry DOI: 10.7270/Q2ZW1JF3
More data for this
Ligand-Target Pair
Golgi alpha-mannosidase II


(Homo sapiens (Human))
BDBM84472
PNG
(Aminocyclopentitetrol, 2e)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O)[C@@H](NCc2ccc(Br)cc2)[C@H]1O
Show InChI InChI=1S/C12H16BrNO4/c13-7-3-1-6(2-4-7)5-14-8-9(15)11(17)12(18)10(8)16/h1-4,8-12,14-18H,5H2/t8-,9+,10-,11+,12-
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7.60E+3 -30.4n/an/an/an/an/a5.637



University of Georgia





Chembiochem 5: 1220-7 (2004)


Article DOI: 10.1002/cbic.200300842
BindingDB Entry DOI: 10.7270/Q2ZW1JF3
More data for this
Ligand-Target Pair
Golgi alpha-mannosidase II


(Homo sapiens (Human))
BDBM84471
PNG
(Aminocyclopentitetrol, 2d)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O)[C@@H](NCc2ccc(Cl)cc2)[C@H]1O
Show InChI InChI=1S/C12H16ClNO4/c13-7-3-1-6(2-4-7)5-14-8-9(15)11(17)12(18)10(8)16/h1-4,8-12,14-18H,5H2/t8-,9+,10-,11+,12-
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8.10E+3 -30.2n/an/an/an/an/a5.637



University of Georgia





Chembiochem 5: 1220-7 (2004)


Article DOI: 10.1002/cbic.200300842
BindingDB Entry DOI: 10.7270/Q2ZW1JF3
More data for this
Ligand-Target Pair
Golgi alpha-mannosidase II


(Homo sapiens (Human))
BDBM84469
PNG
(Aminocyclopentitetrol, 2b)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O)[C@@H](NCc2ccccc2)[C@H]1O
Show InChI InChI=1S/C12H17NO4/c14-9-8(10(15)12(17)11(9)16)13-6-7-4-2-1-3-5-7/h1-5,8-17H,6H2/t8-,9+,10-,11+,12-
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1.00E+4 -29.7n/an/an/an/an/a5.637



University of Georgia





Chembiochem 5: 1220-7 (2004)


Article DOI: 10.1002/cbic.200300842
BindingDB Entry DOI: 10.7270/Q2ZW1JF3
More data for this
Ligand-Target Pair
Golgi alpha-mannosidase II


(Homo sapiens (Human))
BDBM84468
PNG
(Mannostatin analogue, 4b | Meso-aminocyclopentitet...)
Show SMILES N[C@@H]1[C@H](O)[C@H](O)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C5H11NO4/c6-1-2(7)4(9)5(10)3(1)8/h1-5,7-10H,6H2/t1-,2+,3-,4+,5-
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5.00E+4 -25.5n/an/an/an/an/a5.637



University of Georgia





Chembiochem 5: 1220-7 (2004)


Article DOI: 10.1002/cbic.200300842
BindingDB Entry DOI: 10.7270/Q2ZW1JF3
More data for this
Ligand-Target Pair
Golgi alpha-mannosidase II


(Drosophila melanogaster (Fruit fly))
BDBM84869
PNG
(Swainsonine derivative, 4)
Show SMILES CC(C)(C)c1ccc(cc1)C(=O)C[C@H]1CC[C@@H](O)C2[C@H](O)[C@H](O)CN12
Show InChI InChI=1S/C20H29NO4/c1-20(2,3)13-6-4-12(5-7-13)16(23)10-14-8-9-15(22)18-19(25)17(24)11-21(14)18/h4-7,14-15,17-19,22,24-25H,8-11H2,1-3H3/t14-,15-,17-,18?,19-/m1/s1
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2.70 -48.9 29n/an/an/an/a5.7525



University of Toronto



Assay Description
Inhibition of dGMII was measured at pH 5.75. Determination of the IC50 values (concentrations of inhibitor at which 50% of activity remains) was car...


Chembiochem 11: 673-80 (2010)


Article DOI: 10.1002/cbic.200900750
BindingDB Entry DOI: 10.7270/Q2WS8RRM
More data for this
Ligand-Target Pair
Golgi alpha-mannosidase II


(Drosophila melanogaster (Fruit fly))
BDBM84868
PNG
(Swainsonine derivative, 3)
Show SMILES Cc1ccc(cc1)C(=O)C[C@H]1CC[C@@H](O)C2[C@H](O)[C@H](O)CN12
Show InChI InChI=1S/C17H23NO4/c1-10-2-4-11(5-3-10)14(20)8-12-6-7-13(19)16-17(22)15(21)9-18(12)16/h2-5,12-13,15-17,19,21-22H,6-9H2,1H3/t12-,13-,15-,16?,17-/m1/s1
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2.70 -48.9 29n/an/an/an/a5.7525



University of Toronto



Assay Description
Inhibition of dGMII was measured at pH 5.75. Determination of the IC50 values (concentrations of inhibitor at which 50% of activity remains) was car...


Chembiochem 11: 673-80 (2010)


Article DOI: 10.1002/cbic.200900750
BindingDB Entry DOI: 10.7270/Q2WS8RRM
More data for this
Ligand-Target Pair
Golgi alpha-mannosidase II


(Drosophila melanogaster (Fruit fly))
BDBM84867
PNG
(Swainsonine derivative, 2)
Show SMILES O[C@@H]1CN2C([C@@H]1O)[C@H](O)CC[C@@H]2CC(=O)c1ccccc1
Show InChI InChI=1S/C16H21NO4/c18-12-7-6-11(17-9-14(20)16(21)15(12)17)8-13(19)10-4-2-1-3-5-10/h1-5,11-12,14-16,18,20-21H,6-9H2/t11-,12-,14-,15?,16-/m1/s1
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2.80 -48.8 30n/an/an/an/a5.7525



University of Toronto



Assay Description
Inhibition of dGMII was measured at pH 5.75. Determination of the IC50 values (concentrations of inhibitor at which 50% of activity remains) was car...


Chembiochem 11: 673-80 (2010)


Article DOI: 10.1002/cbic.200900750
BindingDB Entry DOI: 10.7270/Q2WS8RRM
More data for this
Ligand-Target Pair
Golgi alpha-mannosidase II


(Drosophila melanogaster (Fruit fly))
BDBM50168995
PNG
((-)-swainsonine | (1S,2R,8R,8aR)-Octahydro-indoliz...)
Show SMILES O[C@@H]1CN2CCC[C@@H](O)[C@@H]2[C@@H]1O
Show InChI InChI=1S/C8H15NO3/c10-5-2-1-3-9-4-6(11)8(12)7(5)9/h5-8,10-12H,1-4H2/t5-,6-,7-,8-/m1/s1
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3 -48.6 37n/an/an/an/a5.7525



University of Toronto



Assay Description
Inhibition of dGMII was measured at pH 5.75. Determination of the IC50 values (concentrations of inhibitor at which 50% of activity remains) was car...


Chembiochem 11: 673-80 (2010)


Article DOI: 10.1002/cbic.200900750
BindingDB Entry DOI: 10.7270/Q2WS8RRM
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Golgi alpha-mannosidase II


(Drosophila melanogaster (Fruit fly))
BDBM84870
PNG
(Swainsonine derivative, 5)
Show SMILES CC(C)(C)c1ccc(cc1)C(=O)C[C@@H]1CC[C@@H](O)C2[C@H](O)[C@H](O)CN12
Show InChI InChI=1S/C20H29NO4/c1-20(2,3)13-6-4-12(5-7-13)16(23)10-14-8-9-15(22)18-19(25)17(24)11-21(14)18/h4-7,14-15,17-19,22,24-25H,8-11H2,1-3H3/t14-,15+,17+,18?,19+/m0/s1
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n/an/a 250n/an/an/an/a5.7525



University of Toronto



Assay Description
Inhibition of dGMII was measured at pH 5.75. Determination of the IC50 values (concentrations of inhibitor at which 50% of activity remains) was car...


Chembiochem 11: 673-80 (2010)


Article DOI: 10.1002/cbic.200900750
BindingDB Entry DOI: 10.7270/Q2WS8RRM
More data for this
Ligand-Target Pair
Golgi alpha-mannosidase II


(Drosophila melanogaster (Fruit fly))
BDBM84872
PNG
(Swainsonine derivative, 7)
Show SMILES CC(C)(C)c1ccc(CC[C@@H]2CC[C@@H](O)C3[C@H](O)[C@H](O)CN23)cc1
Show InChI InChI=1S/C20H31NO3/c1-20(2,3)14-7-4-13(5-8-14)6-9-15-10-11-16(22)18-19(24)17(23)12-21(15)18/h4-5,7-8,15-19,22-24H,6,9-12H2,1-3H3/t15-,16-,17-,18?,19-/m1/s1
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n/an/a 250n/an/an/an/a5.7525



University of Toronto



Assay Description
Inhibition of dGMII was measured at pH 5.75. Determination of the IC50 values (concentrations of inhibitor at which 50% of activity remains) was car...


Chembiochem 11: 673-80 (2010)


Article DOI: 10.1002/cbic.200900750
BindingDB Entry DOI: 10.7270/Q2WS8RRM
More data for this
Ligand-Target Pair
Golgi alpha-mannosidase II


(Drosophila melanogaster (Fruit fly))
BDBM84871
PNG
(Swainsonine derivative, 6)
Show SMILES CC(C)(C)c1ccc(CC[C@H]2CC[C@@H](O)C3[C@H](O)[C@H](O)CN23)cc1
Show InChI InChI=1S/C20H31NO3/c1-20(2,3)14-7-4-13(5-8-14)6-9-15-10-11-16(22)18-19(24)17(23)12-21(15)18/h4-5,7-8,15-19,22-24H,6,9-12H2,1-3H3/t15-,16+,17+,18?,19+/m0/s1
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n/an/a 44n/an/an/an/a5.7525



University of Toronto



Assay Description
Inhibition of dGMII was measured at pH 5.75. Determination of the IC50 values (concentrations of inhibitor at which 50% of activity remains) was car...


Chembiochem 11: 673-80 (2010)


Article DOI: 10.1002/cbic.200900750
BindingDB Entry DOI: 10.7270/Q2WS8RRM
More data for this
Ligand-Target Pair
Alpha-mannosidase


(Glycine max)
BDBM50186734
PNG
(CHEMBL207910 | D-1,4-dideoxy-4,4-difluoronojirimyc...)
Show SMILES OC[C@H]1NC[C@H](O)[C@@H](O)C1(F)F
Show InChI InChI=1S/C6H11F2NO3/c7-6(8)4(2-10)9-1-3(11)5(6)12/h3-5,9-12H,1-2H2/t3-,4+,5+/m0/s1
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>1.00E+6n/an/an/an/an/an/a6.8n/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of jack bean alpha mannosidase at pH 6.8


J Med Chem 49: 2989-97 (2006)


Article DOI: 10.1021/jm060066q
BindingDB Entry DOI: 10.7270/Q29P318F
More data for this
Ligand-Target Pair
Alpha-mannosidase


(Glycine max)
BDBM50186735
PNG
(CHEMBL208021 | D-1,4-dideoxy-4,4-difluoromannonoji...)
Show SMILES OC[C@H]1NC[C@@H](O)[C@@H](O)C1(F)F
Show InChI InChI=1S/C6H11F2NO3/c7-6(8)4(2-10)9-1-3(11)5(6)12/h3-5,9-12H,1-2H2/t3-,4-,5-/m1/s1
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>1.00E+6n/an/an/an/an/an/a6.8n/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of jack bean alpha mannosidase at pH 6.8


J Med Chem 49: 2989-97 (2006)


Article DOI: 10.1021/jm060066q
BindingDB Entry DOI: 10.7270/Q29P318F
More data for this
Ligand-Target Pair
Alpha-mannosidase


(Glycine max)
BDBM50186733
PNG
(CHEMBL208152 | L-1,4,6-trideoxy-4,4-difluoronojiri...)
Show SMILES C[C@@H]1NC[C@@H](O)[C@H](O)C1(F)F
Show InChI InChI=1S/C6H11F2NO2/c1-3-6(7,8)5(11)4(10)2-9-3/h3-5,9-11H,2H2,1H3/t3-,4+,5-/m0/s1
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>1.00E+6n/an/an/an/an/an/a6.8n/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of jack bean alpha mannosidase at pH 6.8


J Med Chem 49: 2989-97 (2006)


Article DOI: 10.1021/jm060066q
BindingDB Entry DOI: 10.7270/Q29P318F
More data for this
Ligand-Target Pair
Alpha-mannosidase


(Glycine max)
BDBM50186734
PNG
(CHEMBL207910 | D-1,4-dideoxy-4,4-difluoronojirimyc...)
Show SMILES OC[C@H]1NC[C@H](O)[C@@H](O)C1(F)F
Show InChI InChI=1S/C6H11F2NO3/c7-6(8)4(2-10)9-1-3(11)5(6)12/h3-5,9-12H,1-2H2/t3-,4+,5+/m0/s1
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>1.00E+6n/an/an/an/an/an/a6.8n/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of almond alpha mannosidase at pH 6.8


J Med Chem 49: 2989-97 (2006)


Article DOI: 10.1021/jm060066q
BindingDB Entry DOI: 10.7270/Q29P318F
More data for this
Ligand-Target Pair
Alpha-mannosidase


(Glycine max)
BDBM50186736
PNG
(CHEMBL380311 | L-1,4-dideoxy-4,4-difluorogulonojir...)
Show SMILES OC[C@@H]1NC[C@@H](O)[C@@H](O)C1(F)F
Show InChI InChI=1S/C6H11F2NO3/c7-6(8)4(2-10)9-1-3(11)5(6)12/h3-5,9-12H,1-2H2/t3-,4+,5-/m1/s1
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>1.00E+6n/an/an/an/an/an/a6.8n/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of jack bean alpha mannosidase at pH 6.8


J Med Chem 49: 2989-97 (2006)


Article DOI: 10.1021/jm060066q
BindingDB Entry DOI: 10.7270/Q29P318F
More data for this
Ligand-Target Pair
Alpha-mannosidase


(Glycine max)
BDBM50186736
PNG
(CHEMBL380311 | L-1,4-dideoxy-4,4-difluorogulonojir...)
Show SMILES OC[C@@H]1NC[C@@H](O)[C@@H](O)C1(F)F
Show InChI InChI=1S/C6H11F2NO3/c7-6(8)4(2-10)9-1-3(11)5(6)12/h3-5,9-12H,1-2H2/t3-,4+,5-/m1/s1
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>1.00E+6n/an/an/an/an/an/a6.8n/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of almond alpha mannosidase at pH 6.8


J Med Chem 49: 2989-97 (2006)


Article DOI: 10.1021/jm060066q
BindingDB Entry DOI: 10.7270/Q29P318F
More data for this
Ligand-Target Pair
Alpha-mannosidase


(Glycine max)
BDBM50186735
PNG
(CHEMBL208021 | D-1,4-dideoxy-4,4-difluoromannonoji...)
Show SMILES OC[C@H]1NC[C@@H](O)[C@@H](O)C1(F)F
Show InChI InChI=1S/C6H11F2NO3/c7-6(8)4(2-10)9-1-3(11)5(6)12/h3-5,9-12H,1-2H2/t3-,4-,5-/m1/s1
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>1.00E+6n/an/an/an/an/an/a6.8n/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of almond alpha mannosidase at pH 6.8


J Med Chem 49: 2989-97 (2006)


Article DOI: 10.1021/jm060066q
BindingDB Entry DOI: 10.7270/Q29P318F
More data for this
Ligand-Target Pair
Alpha-mannosidase


(Glycine max)
BDBM50186732
PNG
(CHEMBL206628 | D-1,4,6-trideoxy-4,4-difluoronojiri...)
Show SMILES C[C@H]1NC[C@H](O)[C@@H](O)C1(F)F
Show InChI InChI=1S/C6H11F2NO2/c1-3-6(7,8)5(11)4(10)2-9-3/h3-5,9-11H,2H2,1H3/t3-,4+,5-/m1/s1
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>1.00E+6n/an/an/an/an/an/a6.8n/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of jack bean alpha mannosidase at pH 6.8


J Med Chem 49: 2989-97 (2006)


Article DOI: 10.1021/jm060066q
BindingDB Entry DOI: 10.7270/Q29P318F
More data for this
Ligand-Target Pair
Alpha-mannosidase


(Glycine max)
BDBM50186732
PNG
(CHEMBL206628 | D-1,4,6-trideoxy-4,4-difluoronojiri...)
Show SMILES C[C@H]1NC[C@H](O)[C@@H](O)C1(F)F
Show InChI InChI=1S/C6H11F2NO2/c1-3-6(7,8)5(11)4(10)2-9-3/h3-5,9-11H,2H2,1H3/t3-,4+,5-/m1/s1
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>1.00E+6n/an/an/an/an/an/a6.8n/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of almond alpha mannosidase at pH 6.8


J Med Chem 49: 2989-97 (2006)


Article DOI: 10.1021/jm060066q
BindingDB Entry DOI: 10.7270/Q29P318F
More data for this
Ligand-Target Pair
Alpha-mannosidase


(Glycine max)
BDBM50186733
PNG
(CHEMBL208152 | L-1,4,6-trideoxy-4,4-difluoronojiri...)
Show SMILES C[C@@H]1NC[C@@H](O)[C@H](O)C1(F)F
Show InChI InChI=1S/C6H11F2NO2/c1-3-6(7,8)5(11)4(10)2-9-3/h3-5,9-11H,2H2,1H3/t3-,4+,5-/m0/s1
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>1.00E+6n/an/an/an/an/an/a6.8n/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of jack bean alpha mannosidase at pH 6.8


J Med Chem 49: 2989-97 (2006)


Article DOI: 10.1021/jm060066q
BindingDB Entry DOI: 10.7270/Q29P318F
More data for this
Ligand-Target Pair
Alpha-mannosidase


(Glycine max)
BDBM50168997
PNG
(4-Fluoro-benzoic acid 2-[((2R,3R,4S)-3,4-dihydroxy...)
Show SMILES O[C@H]1CN[C@H](CNC(COC(=O)c2ccc(F)cc2)c2ccccc2)[C@H]1O
Show InChI InChI=1S/C20H23FN2O4/c21-15-8-6-14(7-9-15)20(26)27-12-17(13-4-2-1-3-5-13)22-10-16-19(25)18(24)11-23-16/h1-9,16-19,22-25H,10-12H2/t16-,17?,18+,19-/m1/s1
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19n/an/an/an/an/an/an/an/a



Institute of Chemical Sciences and Engineering

Curated by ChEMBL


Assay Description
Binding affinity against alpha-Mannosidase isolated from Jack bean


J Med Chem 48: 4237-46 (2005)


Article DOI: 10.1021/jm0409019
BindingDB Entry DOI: 10.7270/Q24J0DNV
More data for this
Ligand-Target Pair
Alpha-mannosidase


(Canavalia ensiformis)
BDBM50124579
PNG
(CHEMBL3621532)
Show SMILES OC[C@]12CCC(=O)N1C[C@H](O)[C@@H](O)[C@@H]2O
Show InChI InChI=1S/C9H15NO5/c11-4-9-2-1-6(13)10(9)3-5(12)7(14)8(9)15/h5,7-8,11-12,14-15H,1-4H2/t5-,7+,8-,9-/m0/s1
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35n/an/an/an/an/an/an/an/a



Savitribai Phule Pune University (formerly University of Pune)

Curated by ChEMBL


Assay Description
Inhibition of jack bean alpha-mannosidase using 10 mM p-nitrophenyl-alpha-D-mannopyranoside as substrate


J Med Chem 58: 7820-32 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00951
BindingDB Entry DOI: 10.7270/Q2G73GKX
More data for this
Ligand-Target Pair
Golgi alpha-mannosidase II


(Drosophila melanogaster (Fruit fly))
BDBM50078117
PNG
((1R,2R,3R,4S,5R)-4-AMINO-5-(METHYLTHIO)CYCLOPENTAN...)
Show SMILES CS[C@@H]1[C@@H](N)[C@@H](O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C6H13NO3S/c1-11-6-2(7)3(8)4(9)5(6)10/h2-6,8-10H,7H2,1H3/t2-,3+,4+,5+,6+/m0/s1
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36n/an/an/an/an/an/an/an/a



University of Toronto



Assay Description
The rate of hydrolysis catalyzed by drosophila golgi alpha-mannosidase II (dGMII)and in the presence of different concentration of inhibitor was meas...


Chembiochem 10: 268-77 (2009)


Article DOI: 10.1002/cbic.200800538
BindingDB Entry DOI: 10.7270/Q2DZ06T7
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Alpha-mannosidase


(Canavalia ensiformis)
BDBM50124578
PNG
(CHEMBL3621533)
Show SMILES OC[C@@]12CCC(=O)N1C[C@H](O)[C@@H](O)[C@@H]2O
Show InChI InChI=1S/C9H15NO5/c11-4-9-2-1-6(13)10(9)3-5(12)7(14)8(9)15/h5,7-8,11-12,14-15H,1-4H2/t5-,7+,8-,9+/m0/s1
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43n/an/an/an/an/an/an/an/a



Savitribai Phule Pune University (formerly University of Pune)

Curated by ChEMBL


Assay Description
Inhibition of jack bean alpha-mannosidase using 10 mM p-nitrophenyl-alpha-D-mannopyranoside as substrate


J Med Chem 58: 7820-32 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00951
BindingDB Entry DOI: 10.7270/Q2G73GKX
More data for this
Ligand-Target Pair
Golgi alpha-mannosidase II


(Drosophila melanogaster (Fruit fly))
BDBM50088625
PNG
((1R,2R,3R,4S,5R)-4-Amino-5-methoxy-cyclopentane-1,...)
Show SMILES CO[C@@H]1[C@@H](N)[C@@H](O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C6H13NO4/c1-11-6-2(7)3(8)4(9)5(6)10/h2-6,8-10H,7H2,1H3/t2-,3+,4+,5+,6+/m0/s1
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76n/an/an/an/an/an/an/an/a



University of Toronto



Assay Description
The rate of hydrolysis catalyzed by drosophila golgi alpha-mannosidase II (dGMII)and in the presence of different concentration of inhibitor was meas...


Chembiochem 10: 268-77 (2009)


Article DOI: 10.1002/cbic.200800538
BindingDB Entry DOI: 10.7270/Q2DZ06T7
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
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