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Compile Data Set for Download or QSAR

Found 3799 hits Enz. Inhib. hit(s) with Target = 'Aminopeptidase'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aminopeptidase N


(Sus scrofa (Pig))
BDBM241960
PNG
(2-[2-(3-amino-2-hydroxypropanamido)-3-phenylpropan...)
Show SMILES CCC(C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](O)CN)C(O)=O
Show InChI InChI=1S/C18H27N3O5/c1-3-11(2)15(18(25)26)21-16(23)13(20-17(24)14(22)10-19)9-12-7-5-4-6-8-12/h4-8,11,13-15,22H,3,9-10,19H2,1-2H3,(H,20,24)(H,21,23)(H,25,26)/t11?,13-,14-,15-/m0/s1
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n/an/a 3.04E+4n/an/an/an/a7.2n/a



Shandong University



Assay Description
IC50 values against APN were determined as previously described and by using L-Leu-p-nitroanilide as a substrate and microsomal aminopeptidase from P...


J Enzyme Inhib Med Chem 28: 717-26 (2013)


Article DOI: 10.3109/14756366.2012.680062
BindingDB Entry DOI: 10.7270/Q2930S39
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM23971
PNG
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1
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n/an/a 2.50E+3n/an/an/an/a7.2n/a



Shandong University



Assay Description
Briefly, the assay was performed in 96-well plates in 50 mm PBS, pH 7.2 as the assay buffer, at 37 C. The APN solution was mixed with compounds at v...


Chem Biol Drug Des 88: 542-55 (2016)


Article DOI: 10.1111/cbdd.12778
BindingDB Entry DOI: 10.7270/Q2HX1BHT
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Aminopeptidase N


(Sus scrofa (Pig))
BDBM241962
PNG
(L-isoserine-L-phenylglycine-L-valine (16c))
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](O)CN)c1ccccc1)C(O)=O
Show InChI InChI=1S/C16H23N3O5/c1-9(2)12(16(23)24)18-15(22)13(10-6-4-3-5-7-10)19-14(21)11(20)8-17/h3-7,9,11-13,20H,8,17H2,1-2H3,(H,18,22)(H,19,21)(H,23,24)/t11-,12-,13-/m0/s1
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n/an/a 5.15E+4n/an/an/an/a7.2n/a



Shandong University



Assay Description
IC50 values against APN were determined as previously described and by using L-Leu-p-nitroanilide as a substrate and microsomal aminopeptidase from P...


J Enzyme Inhib Med Chem 28: 717-26 (2013)


Article DOI: 10.3109/14756366.2012.680062
BindingDB Entry DOI: 10.7270/Q2930S39
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM241963
PNG
(L-isoserine-L-valine-L-phenylalanine (16d))
Show SMILES CC(C)[C@H](NC(=O)[C@@H](O)CN)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C17H25N3O5/c1-10(2)14(20-15(22)13(21)9-18)16(23)19-12(17(24)25)8-11-6-4-3-5-7-11/h3-7,10,12-14,21H,8-9,18H2,1-2H3,(H,19,23)(H,20,22)(H,24,25)/t12-,13-,14-/m0/s1
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n/an/a 3.02E+4n/an/an/an/a7.2n/a



Shandong University



Assay Description
IC50 values against APN were determined as previously described and by using L-Leu-p-nitroanilide as a substrate and microsomal aminopeptidase from P...


J Enzyme Inhib Med Chem 28: 717-26 (2013)


Article DOI: 10.3109/14756366.2012.680062
BindingDB Entry DOI: 10.7270/Q2930S39
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM241964
PNG
(L-isoserine-L-tyrosinase-L-valine (16e))
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](O)CN)C(O)=O
Show InChI InChI=1S/C17H25N3O6/c1-9(2)14(17(25)26)20-15(23)12(19-16(24)13(22)8-18)7-10-3-5-11(21)6-4-10/h3-6,9,12-14,21-22H,7-8,18H2,1-2H3,(H,19,24)(H,20,23)(H,25,26)/t12-,13-,14-/m0/s1
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n/an/a 1.15E+4n/an/an/an/a7.2n/a



Shandong University



Assay Description
IC50 values against APN were determined as previously described and by using L-Leu-p-nitroanilide as a substrate and microsomal aminopeptidase from P...


J Enzyme Inhib Med Chem 28: 717-26 (2013)


Article DOI: 10.3109/14756366.2012.680062
BindingDB Entry DOI: 10.7270/Q2930S39
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM241965
PNG
(L-isoserine-L-valine-L-valine (16f))
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](O)CN)C(C)C)C(O)=O
Show InChI InChI=1S/C13H25N3O5/c1-6(2)9(15-11(18)8(17)5-14)12(19)16-10(7(3)4)13(20)21/h6-10,17H,5,14H2,1-4H3,(H,15,18)(H,16,19)(H,20,21)/t8-,9-,10-/m0/s1
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n/an/a 1.36E+4n/an/an/an/a7.2n/a



Shandong University



Assay Description
IC50 values against APN were determined as previously described and by using L-Leu-p-nitroanilide as a substrate and microsomal aminopeptidase from P...


J Enzyme Inhib Med Chem 28: 717-26 (2013)


Article DOI: 10.3109/14756366.2012.680062
BindingDB Entry DOI: 10.7270/Q2930S39
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM241966
PNG
(L-isoserine-L-phenylglycine-L-phenylalanine (16g))
Show SMILES NC[C@H](O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(O)=O)c1ccccc1
Show InChI InChI=1S/C20H23N3O5/c21-12-16(24)18(25)23-17(14-9-5-2-6-10-14)19(26)22-15(20(27)28)11-13-7-3-1-4-8-13/h1-10,15-17,24H,11-12,21H2,(H,22,26)(H,23,25)(H,27,28)/t15-,16-,17-/m0/s1
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n/an/a 5.80E+3n/an/an/an/a7.2n/a



Shandong University



Assay Description
IC50 values against APN were determined as previously described and by using L-Leu-p-nitroanilide as a substrate and microsomal aminopeptidase from P...


J Enzyme Inhib Med Chem 28: 717-26 (2013)


Article DOI: 10.3109/14756366.2012.680062
BindingDB Entry DOI: 10.7270/Q2930S39
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM241967
PNG
(L-isoserine-L-valine-L-leucyl (16h))
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@@H](O)CN)C(C)C)C(O)=O
Show InChI InChI=1S/C14H27N3O5/c1-7(2)5-9(14(21)22)16-13(20)11(8(3)4)17-12(19)10(18)6-15/h7-11,18H,5-6,15H2,1-4H3,(H,16,20)(H,17,19)(H,21,22)/t9-,10-,11-/m0/s1
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n/an/a 6.50E+3n/an/an/an/a7.2n/a



Shandong University



Assay Description
IC50 values against APN were determined as previously described and by using L-Leu-p-nitroanilide as a substrate and microsomal aminopeptidase from P...


J Enzyme Inhib Med Chem 28: 717-26 (2013)


Article DOI: 10.3109/14756366.2012.680062
BindingDB Entry DOI: 10.7270/Q2930S39
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM241968
PNG
(L-isoserine-L-leucyl-L-valine (16i))
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)CN)C(=O)N[C@@H](C(C)C)C(O)=O
Show InChI InChI=1S/C14H27N3O5/c1-7(2)5-9(16-13(20)10(18)6-15)12(19)17-11(8(3)4)14(21)22/h7-11,18H,5-6,15H2,1-4H3,(H,16,20)(H,17,19)(H,21,22)/t9-,10-,11-/m0/s1
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n/an/a 5.16E+3n/an/an/an/a7.2n/a



Shandong University



Assay Description
IC50 values against APN were determined as previously described and by using L-Leu-p-nitroanilide as a substrate and microsomal aminopeptidase from P...


J Enzyme Inhib Med Chem 28: 717-26 (2013)


Article DOI: 10.3109/14756366.2012.680062
BindingDB Entry DOI: 10.7270/Q2930S39
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM241969
PNG
(L-isoserine-L-phenylglycine-L-leucyl (16k))
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@@H](O)CN)c1ccccc1)C(O)=O
Show InChI InChI=1S/C17H25N3O5/c1-10(2)8-12(17(24)25)19-16(23)14(11-6-4-3-5-7-11)20-15(22)13(21)9-18/h3-7,10,12-14,21H,8-9,18H2,1-2H3,(H,19,23)(H,20,22)(H,24,25)/t12-,13-,14-/m0/s1
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n/an/a 1.16E+4n/an/an/an/a7.2n/a



Shandong University



Assay Description
IC50 values against APN were determined as previously described and by using L-Leu-p-nitroanilide as a substrate and microsomal aminopeptidase from P...


J Enzyme Inhib Med Chem 28: 717-26 (2013)


Article DOI: 10.3109/14756366.2012.680062
BindingDB Entry DOI: 10.7270/Q2930S39
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM241970
PNG
(L-isoserine-L-tyrosinase-L-leucyl (16l))
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](O)CN)C(O)=O
Show InChI InChI=1S/C18H27N3O6/c1-10(2)7-14(18(26)27)21-16(24)13(20-17(25)15(23)9-19)8-11-3-5-12(22)6-4-11/h3-6,10,13-15,22-23H,7-9,19H2,1-2H3,(H,20,25)(H,21,24)(H,26,27)/t13-,14-,15-/m0/s1
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n/an/a 2.51E+3n/an/an/an/a7.2n/a



Shandong University



Assay Description
IC50 values against APN were determined as previously described and by using L-Leu-p-nitroanilide as a substrate and microsomal aminopeptidase from P...


J Enzyme Inhib Med Chem 28: 717-26 (2013)


Article DOI: 10.3109/14756366.2012.680062
BindingDB Entry DOI: 10.7270/Q2930S39
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM241971
PNG
(L-isoserine-L-eucyl-L-tyrosinase (16m))
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)CN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C18H27N3O6/c1-10(2)7-13(20-17(25)15(23)9-19)16(24)21-14(18(26)27)8-11-3-5-12(22)6-4-11/h3-6,10,13-15,22-23H,7-9,19H2,1-2H3,(H,20,25)(H,21,24)(H,26,27)/t13-,14-,15-/m0/s1
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n/an/a 1.75E+4n/an/an/an/a7.2n/a



Shandong University



Assay Description
IC50 values against APN were determined as previously described and by using L-Leu-p-nitroanilide as a substrate and microsomal aminopeptidase from P...


J Enzyme Inhib Med Chem 28: 717-26 (2013)


Article DOI: 10.3109/14756366.2012.680062
BindingDB Entry DOI: 10.7270/Q2930S39
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM241972
PNG
(L-isoserine-L-phenylalanine-L-phenylalanine (16n))
Show SMILES NC[C@H](O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C21H25N3O5/c22-13-18(25)20(27)23-16(11-14-7-3-1-4-8-14)19(26)24-17(21(28)29)12-15-9-5-2-6-10-15/h1-10,16-18,25H,11-13,22H2,(H,23,27)(H,24,26)(H,28,29)/t16-,17-,18-/m0/s1
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n/an/a 6.50E+3n/an/an/an/a7.2n/a



Shandong University



Assay Description
IC50 values against APN were determined as previously described and by using L-Leu-p-nitroanilide as a substrate and microsomal aminopeptidase from P...


J Enzyme Inhib Med Chem 28: 717-26 (2013)


Article DOI: 10.3109/14756366.2012.680062
BindingDB Entry DOI: 10.7270/Q2930S39
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM23971
PNG
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1
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n/an/a 6.25E+3n/an/an/an/a7.2n/a



Shandong University



Assay Description
IC50 values against APN were determined as previously described and by using L-Leu-p-nitroanilide as a substrate and microsomal aminopeptidase from P...


J Enzyme Inhib Med Chem 28: 717-26 (2013)


Article DOI: 10.3109/14756366.2012.680062
BindingDB Entry DOI: 10.7270/Q2930S39
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Aminopeptidase N


(Sus scrofa (Pig))
BDBM241961
PNG
(L-isoserine-L-phenylalanine-L-valine (16b))
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](O)CN)C(O)=O
Show InChI InChI=1S/C17H25N3O5/c1-10(2)14(17(24)25)20-15(22)12(19-16(23)13(21)9-18)8-11-6-4-3-5-7-11/h3-7,10,12-14,21H,8-9,18H2,1-2H3,(H,19,23)(H,20,22)(H,24,25)/t12-,13-,14-/m0/s1
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n/an/a 9.40E+4n/an/an/an/a7.2n/a



Shandong University



Assay Description
IC50 values against APN were determined as previously described and by using L-Leu-p-nitroanilide as a substrate and microsomal aminopeptidase from P...


J Enzyme Inhib Med Chem 28: 717-26 (2013)


Article DOI: 10.3109/14756366.2012.680062
BindingDB Entry DOI: 10.7270/Q2930S39
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50061625
PNG
(4-[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthal...)
Show SMILES CC1(C)CCC(C)(C)c2cc(NC(=O)c3ccc(cc3)C(O)=O)ccc12
Show InChI InChI=1S/C22H25NO3/c1-21(2)11-12-22(3,4)18-13-16(9-10-17(18)21)23-19(24)14-5-7-15(8-6-14)20(25)26/h5-10,13H,11-12H2,1-4H3,(H,23,24)(H,25,26)
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n/an/a>1.00E+5n/an/an/an/a7.2n/a



Shandong University



Assay Description
Briefly, the assay was performed in 96-well plates in 50 mm PBS, pH 7.2 as the assay buffer, at 37 C. The APN solution was mixed with compounds at v...


Chem Biol Drug Des 88: 542-55 (2016)


Article DOI: 10.1111/cbdd.12778
BindingDB Entry DOI: 10.7270/Q2HX1BHT
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM19149
PNG
(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Show SMILES ONC(=O)CCCCCCC(=O)Nc1ccccc1
Show InChI InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)
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n/an/a>1.00E+5n/an/an/an/a7.2n/a



Shandong University



Assay Description
Briefly, the assay was performed in 96-well plates in 50 mm PBS, pH 7.2 as the assay buffer, at 37 C. The APN solution was mixed with compounds at v...


Chem Biol Drug Des 88: 542-55 (2016)


Article DOI: 10.1111/cbdd.12778
BindingDB Entry DOI: 10.7270/Q2HX1BHT
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM198191
PNG
(N1-hydroxy-N4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahy...)
Show SMILES CC1(C)CCC(C)(C)c2cc(NC(=O)c3ccc(cc3)C(=O)NO)ccc12
Show InChI InChI=1S/C24H30N2O3/c1-23(2)12-13-24(3,4)20-15-18(9-10-19(20)23)26-22(28)17-7-5-16(6-8-17)21(27)11-14-25-29/h5-10,15,25,29H,11-14H2,1-4H3,(H,26,28)
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n/an/a>1.00E+5n/an/an/an/a7.2n/a



Shandong University



Assay Description
Briefly, the assay was performed in 96-well plates in 50 mm PBS, pH 7.2 as the assay buffer, at 37 C. The APN solution was mixed with compounds at v...


Chem Biol Drug Des 88: 542-55 (2016)


Article DOI: 10.1111/cbdd.12778
BindingDB Entry DOI: 10.7270/Q2HX1BHT
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM36597
PNG
(FOS-69)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@@]1(O)[C@]1(C)OC1CC=C(C)C)OC(=O)CCCCl
Show InChI InChI=1S/C20H31ClO6/c1-13(2)7-8-15-18(3,27-15)20(23)17(24-4)14(9-10-19(20)12-25-19)26-16(22)6-5-11-21/h7,14-15,17,23H,5-6,8-12H2,1-4H3/t14-,15?,17-,18-,19+,20+/m1/s1
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n/an/a 0.100n/an/an/an/a7.3537



Massachusetts Institute of Technology



Assay Description
Enzymatic assay using recombinant human type 2 methionine aminopeptidase (MetAP2).


Chem Biol 4: 461-71 (1997)


Article DOI: 10.1124/jpet.103.062398
BindingDB Entry DOI: 10.7270/Q2NG4P04
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM36592
PNG
(FOS-70)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)C1[C@]1(C)OC1CC=C(C)C)OC(=O)CCCCl
Show InChI InChI=1S/C20H31ClO5/c1-13(2)7-8-15-19(3,26-15)18-17(23-4)14(9-10-20(18)12-24-20)25-16(22)6-5-11-21/h7,14-15,17-18H,5-6,8-12H2,1-4H3/t14-,15?,17-,18?,19-,20+/m1/s1
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n/an/a 3.5n/an/an/an/a7.3537



Massachusetts Institute of Technology



Assay Description
Enzymatic assay using recombinant human type 2 methionine aminopeptidase (MetAP2).


Chem Biol 4: 461-71 (1997)


Article DOI: 10.1124/jpet.103.062398
BindingDB Entry DOI: 10.7270/Q2NG4P04
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM36591
PNG
(FOS-37)
Show SMILES CO[C@@H]1[C@H](O)CC[C@]2(CO2)C1[C@]1(C)OC1CC=C(C)C
Show InChI InChI=1S/C16H26O4/c1-10(2)5-6-12-15(3,20-12)14-13(18-4)11(17)7-8-16(14)9-19-16/h5,11-14,17H,6-9H2,1-4H3/t11-,12?,13-,14?,15-,16+/m1/s1
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n/an/a 8n/an/an/an/a7.3537



Massachusetts Institute of Technology



Assay Description
Enzymatic assay using recombinant human type 2 methionine aminopeptidase (MetAP2).


Chem Biol 4: 461-71 (1997)


Article DOI: 10.1124/jpet.103.062398
BindingDB Entry DOI: 10.7270/Q2NG4P04
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM36596
PNG
(FOS-34)
Show SMILES CO[C@@H]1[C@H](O)CC[C@]2(CO2)[C@@]1(O)[C@]1(C)OC1CC=C(C)C
Show InChI InChI=1S/C16H26O5/c1-10(2)5-6-12-14(3,21-12)16(18)13(19-4)11(17)7-8-15(16)9-20-15/h5,11-13,17-18H,6-9H2,1-4H3/t11-,12?,13-,14-,15+,16+/m1/s1
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n/an/a 4n/an/an/an/a7.3537



Massachusetts Institute of Technology



Assay Description
Enzymatic assay using recombinant human type 2 methionine aminopeptidase (MetAP2).


Chem Biol 4: 461-71 (1997)


Article DOI: 10.1124/jpet.103.062398
BindingDB Entry DOI: 10.7270/Q2NG4P04
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM36593
PNG
(FOS-64)
Show SMILES CO[C@@H]1[C@@H](CC[C@](O)(SC)C1[C@]1(C)OC1CC=C(C)C)OC(=O)NC(=O)CCl
Show InChI InChI=1S/C19H30ClNO6S/c1-11(2)6-7-13-18(3,27-13)16-15(25-4)12(8-9-19(16,24)28-5)26-17(23)21-14(22)10-20/h6,12-13,15-16,24H,7-10H2,1-5H3,(H,21,22,23)/t12-,13?,15-,16?,18-,19+/m1/s1
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n/an/a 3.00E+3n/an/an/an/a7.3537



Massachusetts Institute of Technology



Assay Description
Enzymatic assay using recombinant human type 2 methionine aminopeptidase (MetAP2).


Chem Biol 4: 461-71 (1997)


Article DOI: 10.1124/jpet.103.062398
BindingDB Entry DOI: 10.7270/Q2NG4P04
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM36588
PNG
(AGM-1470)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)C1[C@]1(C)OC1CC=C(C)C)OC(=O)NC(=O)CCl
Show InChI InChI=1S/C19H28ClNO6/c1-11(2)5-6-13-18(3,27-13)16-15(24-4)12(7-8-19(16)10-25-19)26-17(23)21-14(22)9-20/h5,12-13,15-16H,6-10H2,1-4H3,(H,21,22,23)/t12-,13?,15-,16?,18-,19+/m1/s1
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n/an/a 1n/an/an/an/a7.3537



Massachusetts Institute of Technology



Assay Description
Enzymatic assay using recombinant human type 2 methionine aminopeptidase (MetAP2).


Chem Biol 4: 461-71 (1997)


Article DOI: 10.1124/jpet.103.062398
BindingDB Entry DOI: 10.7270/Q2NG4P04
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM36594
PNG
(FOS-202)
Show SMILES CO[C@@H]1[C@H](O)CC[C@](O)(SC)C1[C@]1(C)OC1CC=C(C)C
Show InChI InChI=1S/C16H28O4S/c1-10(2)6-7-12-15(3,20-12)14-13(19-4)11(17)8-9-16(14,18)21-5/h6,11-14,17-18H,7-9H2,1-5H3/t11-,12?,13-,14?,15-,16+/m1/s1
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n/an/a 5.00E+3n/an/an/an/a7.3537



Massachusetts Institute of Technology



Assay Description
Enzymatic assay using recombinant human type 2 methionine aminopeptidase (MetAP2).


Chem Biol 4: 461-71 (1997)


Article DOI: 10.1124/jpet.103.062398
BindingDB Entry DOI: 10.7270/Q2NG4P04
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM36595
PNG
(FOS-68)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@@]1(O)[C@]1(C)OC1CC=C(C)C)OC(=O)NC(=O)CCl
Show InChI InChI=1S/C19H28ClNO7/c1-11(2)5-6-13-17(3,28-13)19(24)15(25-4)12(7-8-18(19)10-26-18)27-16(23)21-14(22)9-20/h5,12-13,15,24H,6-10H2,1-4H3,(H,21,22,23)/t12-,13?,15-,17-,18+,19+/m1/s1
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n/an/a 2n/an/an/an/a7.3537



Massachusetts Institute of Technology



Assay Description
Enzymatic assay using recombinant human type 2 methionine aminopeptidase (MetAP2).


Chem Biol 4: 461-71 (1997)


Article DOI: 10.1124/jpet.103.062398
BindingDB Entry DOI: 10.7270/Q2NG4P04
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM36590
PNG
(FOS-72)
Show SMILES CO[C@H]1C([C@]2(C)OC2CC=C(C)C)[C@@]2(CO2)CCC1=O
Show InChI InChI=1S/C16H24O4/c1-10(2)5-6-12-15(3,20-12)14-13(18-4)11(17)7-8-16(14)9-19-16/h5,12-14H,6-9H2,1-4H3/t12?,13-,14?,15-,16+/m1/s1
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n/an/a 6n/an/an/an/a7.3537



Massachusetts Institute of Technology



Assay Description
Enzymatic assay using recombinant human type 2 methionine aminopeptidase (MetAP2).


Chem Biol 4: 461-71 (1997)


Article DOI: 10.1124/jpet.103.062398
BindingDB Entry DOI: 10.7270/Q2NG4P04
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM36589
PNG
(Ovalicin)
Show SMILES CO[C@@H]1C(=O)CC[C@]2(CO2)[C@@]1(O)[C@]1(C)OC1CC=C(C)C
Show InChI InChI=1S/C16H24O5/c1-10(2)5-6-12-14(3,21-12)16(18)13(19-4)11(17)7-8-15(16)9-20-15/h5,12-13,18H,6-9H2,1-4H3/t12?,13-,14-,15+,16+/m1/s1
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n/an/a 0.400n/an/an/an/a7.3537



Massachusetts Institute of Technology



Assay Description
Enzymatic assay using recombinant human type 2 methionine aminopeptidase (MetAP2).


Chem Biol 4: 461-71 (1997)


Article DOI: 10.1124/jpet.103.062398
BindingDB Entry DOI: 10.7270/Q2NG4P04
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM36599
PNG
(FOS-201)
Show SMILES CO[C@@H]1[C@H](O)CC[C@](O)(SC)[C@@]1(O)[C@]1(C)OC1CC=C(C)C
Show InChI InChI=1S/C16H28O5S/c1-10(2)6-7-12-14(3,21-12)16(19)13(20-4)11(17)8-9-15(16,18)22-5/h6,11-13,17-19H,7-9H2,1-5H3/t11-,12?,13-,14-,15+,16+/m1/s1
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n/an/a 45n/an/an/an/a7.3537



Massachusetts Institute of Technology



Assay Description
Enzymatic assay using recombinant human type 2 methionine aminopeptidase (MetAP2).


Chem Biol 4: 461-71 (1997)


Article DOI: 10.1124/jpet.103.062398
BindingDB Entry DOI: 10.7270/Q2NG4P04
More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (human))
BDBM149584
PNG
(US10023561, Example 39 | US9682965, 39)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)N1CC(CCN2CCOCC2=O)C1
Show InChI InChI=1S/C26H40N2O7/c1-17(2)5-6-20-25(3,35-20)23-22(31-4)19(7-9-26(23)16-33-26)34-24(30)28-13-18(14-28)8-10-27-11-12-32-15-21(27)29/h5,18-20,22-23H,6-16H2,1-4H3/t19-,20-,22-,23-,25+,26+/m1/s1
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n/an/a 275n/an/an/an/a7.4n/a



Zafgen, Inc.

US Patent


Assay Description
The plate was sealed with a TopSeal A cover and mixed briefly on an orbital mixer at 900 rpm. The plate was incubated for a further 25 minutes at 25...


US Patent US10023561 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (human))
BDBM152576
PNG
(US10023561, Example 66 | US9682965, 66)
Show SMILES CCN(CC)CCNC(=O)CC1CN(C1)C(=O)O[C@@H]1CC[C@]2(CO2)[C@H]([C@@H]1OC)[C@@]1(C)O[C@@H]1CC=C(C)C
Show InChI InChI=1S/C28H47N3O6/c1-7-30(8-2)14-13-29-23(32)15-20-16-31(17-20)26(33)36-21-11-12-28(18-35-28)25(24(21)34-6)27(5)22(37-27)10-9-19(3)4/h9,20-22,24-25H,7-8,10-18H2,1-6H3,(H,29,32)/t21-,22-,24-,25-,27+,28+/m1/s1
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n/an/a<50n/an/an/an/a7.4n/a



Zafgen, Inc.

US Patent


Assay Description
The plate was sealed with a TopSeal A cover and mixed briefly on an orbital mixer at 900 rpm. The plate was incubated for a further 25 minutes at 25...


US Patent US10023561 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (human))
BDBM152677
PNG
(US10023561, Example 95 | US9682965, 95)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)N1CC(CN2CCOCC2)C1
Show InChI InChI=1S/C25H40N2O6/c1-17(2)5-6-20-24(3,33-20)22-21(29-4)19(7-8-25(22)16-31-25)32-23(28)27-14-18(15-27)13-26-9-11-30-12-10-26/h5,18-22H,6-16H2,1-4H3/t19-,20-,21-,22-,24+,25+/m1/s1
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n/an/a 275n/an/an/an/a7.4n/a



Zafgen, Inc.

US Patent


Assay Description
The plate was sealed with a TopSeal A cover and mixed briefly on an orbital mixer at 900 rpm. The plate was incubated for a further 25 minutes at 25...


US Patent US10023561 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (human))
BDBM152584
PNG
(US10023561, Example 74 | US9682965, 74)
Show SMILES CNC(=O)OC1CN(C1)C(=O)O[C@@H]1CC[C@]2(CO2)[C@H]([C@@H]1OC)[C@@]1(C)O[C@@H]1CC=C(C)C
Show InChI InChI=1S/C22H34N2O7/c1-13(2)6-7-16-21(3,31-16)18-17(27-5)15(8-9-22(18)12-28-22)30-20(26)24-10-14(11-24)29-19(25)23-4/h6,14-18H,7-12H2,1-5H3,(H,23,25)/t15-,16-,17-,18-,21+,22+/m1/s1
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n/an/a<50n/an/an/an/a7.4n/a



Zafgen, Inc.

US Patent


Assay Description
The plate was sealed with a TopSeal A cover and mixed briefly on an orbital mixer at 900 rpm. The plate was incubated for a further 25 minutes at 25...


US Patent US10023561 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (human))
BDBM152582
PNG
(US10023561, Example 72 | US9682965, 72)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)N1CC(C1)OC(N)=O
Show InChI InChI=1S/C21H32N2O7/c1-12(2)5-6-15-20(3,30-15)17-16(26-4)14(7-8-21(17)11-27-21)29-19(25)23-9-13(10-23)28-18(22)24/h5,13-17H,6-11H2,1-4H3,(H2,22,24)/t14-,15-,16-,17-,20+,21+/m1/s1
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n/an/a<50n/an/an/an/a7.4n/a



Zafgen, Inc.

US Patent


Assay Description
The plate was sealed with a TopSeal A cover and mixed briefly on an orbital mixer at 900 rpm. The plate was incubated for a further 25 minutes at 25...


US Patent US10023561 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (human))
BDBM152580
PNG
(US10023561, Example 69 | US9682965, 69)
Show SMILES CNC(=O)OCC1CN(C1)C(=O)O[C@@H]1CC[C@]2(CO2)[C@H]([C@@H]1OC)[C@@]1(C)O[C@@H]1CC=C(C)C
Show InChI InChI=1S/C23H36N2O7/c1-14(2)6-7-17-22(3,32-17)19-18(28-5)16(8-9-23(19)13-30-23)31-21(27)25-10-15(11-25)12-29-20(26)24-4/h6,15-19H,7-13H2,1-5H3,(H,24,26)/t16-,17-,18-,19-,22+,23+/m1/s1
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n/an/a 275n/an/an/an/a7.4n/a



Zafgen, Inc.

US Patent


Assay Description
The plate was sealed with a TopSeal A cover and mixed briefly on an orbital mixer at 900 rpm. The plate was incubated for a further 25 minutes at 25...


US Patent US10023561 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (human))
BDBM152679
PNG
(US10023561, Example 98 | US9682965, 98)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)N1CC(C1)Nc1ccccn1
Show InChI InChI=1S/C25H35N3O5/c1-16(2)8-9-19-24(3,33-19)22-21(30-4)18(10-11-25(22)15-31-25)32-23(29)28-13-17(14-28)27-20-7-5-6-12-26-20/h5-8,12,17-19,21-22H,9-11,13-15H2,1-4H3,(H,26,27)/t18-,19-,21-,22-,24+,25+/m1/s1
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n/an/a 275n/an/an/an/a7.4n/a



Zafgen, Inc.

US Patent


Assay Description
The plate was sealed with a TopSeal A cover and mixed briefly on an orbital mixer at 900 rpm. The plate was incubated for a further 25 minutes at 25...


US Patent US10023561 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (human))
BDBM152680
PNG
(US10023561, Example 100 | US9682965, 100)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)N1CC(Cc2ccccn2)C1
Show InChI InChI=1S/C26H36N2O5/c1-17(2)8-9-21-25(3,33-21)23-22(30-4)20(10-11-26(23)16-31-26)32-24(29)28-14-18(15-28)13-19-7-5-6-12-27-19/h5-8,12,18,20-23H,9-11,13-16H2,1-4H3/t20-,21-,22-,23-,25+,26+/m1/s1
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n/an/a 275n/an/an/an/a7.4n/a



Zafgen, Inc.

US Patent


Assay Description
The plate was sealed with a TopSeal A cover and mixed briefly on an orbital mixer at 900 rpm. The plate was incubated for a further 25 minutes at 25...


US Patent US10023561 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (human))
BDBM148478
PNG
(US10023561, Example 37 | US9682965, 37)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)N1CC[C@@H](CN2CCOCC2)C1
Show InChI InChI=1S/C26H42N2O6/c1-18(2)5-6-21-25(3,34-21)23-22(30-4)20(7-9-26(23)17-32-26)33-24(29)28-10-8-19(16-28)15-27-11-13-31-14-12-27/h5,19-23H,6-17H2,1-4H3/t19-,20+,21+,22+,23+,25-,26-/m0/s1
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n/an/a 275n/an/an/an/a7.4n/a



Zafgen, Inc.

US Patent


Assay Description
The plate was sealed with a TopSeal A cover and mixed briefly on an orbital mixer at 900 rpm. The plate was incubated for a further 25 minutes at 25...


US Patent US10023561 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (human))
BDBM152763
PNG
(US10023561, Example 127 | US9682965, 127)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CCC(C)C)OC(=O)N1CC(CCN2CCOCC2)C1
Show InChI InChI=1S/C26H44N2O6/c1-18(2)5-6-21-25(3,34-21)23-22(30-4)20(7-9-26(23)17-32-26)33-24(29)28-15-19(16-28)8-10-27-11-13-31-14-12-27/h18-23H,5-17H2,1-4H3/t20-,21-,22-,23-,25+,26+/m1/s1
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n/an/a 275n/an/an/an/a7.4n/a



Zafgen, Inc.

US Patent


Assay Description
The plate was sealed with a TopSeal A cover and mixed briefly on an orbital mixer at 900 rpm. The plate was incubated for a further 25 minutes at 25...


US Patent US10023561 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (human))
BDBM150748
PNG
(US10023561, Example 45 | US9682965, 45)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)N1CC(CCN2CCC(F)(F)C2)C1
Show InChI InChI=1S/C26H40F2N2O5/c1-17(2)5-6-20-24(3,35-20)22-21(32-4)19(7-9-25(22)16-33-25)34-23(31)30-13-18(14-30)8-11-29-12-10-26(27,28)15-29/h5,18-22H,6-16H2,1-4H3/t19-,20-,21-,22-,24+,25+/m1/s1
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n/an/a 275n/an/an/an/a7.4n/a



Zafgen, Inc.

US Patent


Assay Description
The plate was sealed with a TopSeal A cover and mixed briefly on an orbital mixer at 900 rpm. The plate was incubated for a further 25 minutes at 25...


US Patent US10023561 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (human))
BDBM152681
PNG
(US10023561, Example 101 | US9682965, 101)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)N1CC(Cc2ccc(C)nc2)C1
Show InChI InChI=1S/C27H38N2O5/c1-17(2)6-9-22-26(4,34-22)24-23(31-5)21(10-11-27(24)16-32-27)33-25(30)29-14-20(15-29)12-19-8-7-18(3)28-13-19/h6-8,13,20-24H,9-12,14-16H2,1-5H3/t21-,22-,23-,24-,26+,27+/m1/s1
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n/an/a 275n/an/an/an/a7.4n/a



Zafgen, Inc.

US Patent


Assay Description
The plate was sealed with a TopSeal A cover and mixed briefly on an orbital mixer at 900 rpm. The plate was incubated for a further 25 minutes at 25...


US Patent US10023561 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (human))
BDBM152144
PNG
(US10023561, Example 54 | US9682965, 54)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)N1CC[C@H](CCN2CCOCC2)C1
Show InChI InChI=1S/C27H44N2O6/c1-19(2)5-6-22-26(3,35-22)24-23(31-4)21(7-10-27(24)18-33-27)34-25(30)29-12-9-20(17-29)8-11-28-13-15-32-16-14-28/h5,20-24H,6-18H2,1-4H3/t20-,21+,22+,23+,24+,26-,27-/m0/s1
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Zafgen, Inc.

US Patent


Assay Description
The plate was sealed with a TopSeal A cover and mixed briefly on an orbital mixer at 900 rpm. The plate was incubated for a further 25 minutes at 25...


US Patent US10023561 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (human))
BDBM150800
PNG
(US10023561, Example 53 | US9682965, 53)
Show SMILES CCN(CC)CC[C@H]1CCN(C1)C(=O)O[C@@H]1CC[C@]2(CO2)[C@H]([C@@H]1OC)[C@@]1(C)O[C@@H]1CC=C(C)C
Show InChI InChI=1S/C27H46N2O5/c1-7-28(8-2)15-12-20-13-16-29(17-20)25(30)33-21-11-14-27(18-32-27)24(23(21)31-6)26(5)22(34-26)10-9-19(3)4/h9,20-24H,7-8,10-18H2,1-6H3/t20-,21+,22+,23+,24+,26-,27-/m0/s1
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Zafgen, Inc.

US Patent


Assay Description
The plate was sealed with a TopSeal A cover and mixed briefly on an orbital mixer at 900 rpm. The plate was incubated for a further 25 minutes at 25...


US Patent US10023561 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (human))
BDBM148477
PNG
(US10023561, Example 34 | US9682965, 34)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)N1CC(CCN2CCN(CC(F)F)CC2)C1
Show InChI InChI=1S/C28H45F2N3O5/c1-19(2)5-6-22-27(3,38-22)25-24(35-4)21(7-9-28(25)18-36-28)37-26(34)33-15-20(16-33)8-10-31-11-13-32(14-12-31)17-23(29)30/h5,20-25H,6-18H2,1-4H3/t21-,22-,24-,25-,27+,28+/m1/s1
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n/an/a 275n/an/an/an/a7.4n/a



Zafgen, Inc.

US Patent


Assay Description
The plate was sealed with a TopSeal A cover and mixed briefly on an orbital mixer at 900 rpm. The plate was incubated for a further 25 minutes at 25...


US Patent US10023561 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (human))
BDBM152670
PNG
(US10023561, Example 88 | US9682965, 88)
Show SMILES CCN(CC)CCNC(=O)CCC1CN(C1)C(=O)O[C@@H]1CC[C@]2(CO2)[C@H]([C@@H]1OC)[C@@]1(C)O[C@@H]1CC=C(C)C
Show InChI InChI=1S/C29H49N3O6/c1-7-31(8-2)16-15-30-24(33)12-10-21-17-32(18-21)27(34)37-22-13-14-29(19-36-29)26(25(22)35-6)28(5)23(38-28)11-9-20(3)4/h9,21-23,25-26H,7-8,10-19H2,1-6H3,(H,30,33)/t22-,23-,25-,26-,28+,29+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
The plate was sealed with a TopSeal A cover and mixed briefly on an orbital mixer at 900 rpm. The plate was incubated for a further 25 minutes at 25...


US Patent US10023561 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (human))
BDBM152146
PNG
(US10023561, Example 55 | US9682965, 55)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)N1CC[C@@H](CCN2CCOCC2)C1
Show InChI InChI=1S/C27H44N2O6/c1-19(2)5-6-22-26(3,35-22)24-23(31-4)21(7-10-27(24)18-33-27)34-25(30)29-12-9-20(17-29)8-11-28-13-15-32-16-14-28/h5,20-24H,6-18H2,1-4H3/t20-,21-,22-,23-,24-,26+,27+/m1/s1
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n/an/a 275n/an/an/an/a7.4n/a



Zafgen, Inc.

US Patent


Assay Description
The plate was sealed with a TopSeal A cover and mixed briefly on an orbital mixer at 900 rpm. The plate was incubated for a further 25 minutes at 25...


US Patent US10023561 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (human))
BDBM152147
PNG
(US10023561, Example 56 | US9682965, 56)
Show SMILES CCN(CC)CC[C@@H]1CCN(C1)C(=O)O[C@@H]1CC[C@]2(CO2)[C@H]([C@@H]1OC)[C@@]1(C)O[C@@H]1CC=C(C)C
Show InChI InChI=1S/C27H46N2O5/c1-7-28(8-2)15-12-20-13-16-29(17-20)25(30)33-21-11-14-27(18-32-27)24(23(21)31-6)26(5)22(34-26)10-9-19(3)4/h9,20-24H,7-8,10-18H2,1-6H3/t20-,21-,22-,23-,24-,26+,27+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
The plate was sealed with a TopSeal A cover and mixed briefly on an orbital mixer at 900 rpm. The plate was incubated for a further 25 minutes at 25...


US Patent US10023561 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (human))
BDBM152159
PNG
(US10023561, Example 57 | US9682965, 57)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)N1CC[C@H](CCN2CC(F)(F)C2)C1
Show InChI InChI=1S/C26H40F2N2O5/c1-17(2)5-6-20-24(3,35-20)22-21(32-4)19(7-10-25(22)16-33-25)34-23(31)30-12-9-18(13-30)8-11-29-14-26(27,28)15-29/h5,18-22H,6-16H2,1-4H3/t18-,19+,20+,21+,22+,24-,25-/m0/s1
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Zafgen, Inc.

US Patent


Assay Description
The plate was sealed with a TopSeal A cover and mixed briefly on an orbital mixer at 900 rpm. The plate was incubated for a further 25 minutes at 25...


US Patent US10023561 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (human))
BDBM152191
PNG
(US10023561, Example 58 | US9682965, 58)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)N1CC[C@@H](CCN2CC(F)(F)C2)C1
Show InChI InChI=1S/C26H40F2N2O5/c1-17(2)5-6-20-24(3,35-20)22-21(32-4)19(7-10-25(22)16-33-25)34-23(31)30-12-9-18(13-30)8-11-29-14-26(27,28)15-29/h5,18-22H,6-16H2,1-4H3/t18-,19-,20-,21-,22-,24+,25+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
The plate was sealed with a TopSeal A cover and mixed briefly on an orbital mixer at 900 rpm. The plate was incubated for a further 25 minutes at 25...


US Patent US10023561 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (human))
BDBM148472
PNG
(US10023561, Example 22 | US9682965, 22)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)N1CC(CCN2CC3C(C2)C3(F)F)C1
Show InChI InChI=1S/C27H40F2N2O5/c1-16(2)5-6-21-25(3,36-21)23-22(33-4)20(7-9-26(23)15-34-26)35-24(32)31-11-17(12-31)8-10-30-13-18-19(14-30)27(18,28)29/h5,17-23H,6-15H2,1-4H3/t18?,19?,20-,21-,22-,23-,25+,26+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
The plate was sealed with a TopSeal A cover and mixed briefly on an orbital mixer at 900 rpm. The plate was incubated for a further 25 minutes at 25...


US Patent US10023561 (2018)

More data for this
Ligand-Target Pair
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