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Compile Data Set for Download or QSAR

Found 1166 hits Enz. Inhib. hit(s) with Target = 'Aminopeptidase N'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aminopeptidase N


(Sus scrofa (Pig))
BDBM198191
PNG
(N1-hydroxy-N4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahy...)
Show SMILES CC1(C)CCC(C)(C)c2cc(NC(=O)c3ccc(cc3)C(=O)NO)ccc12
Show InChI InChI=1S/C24H30N2O3/c1-23(2)12-13-24(3,4)20-15-18(9-10-19(20)23)26-22(28)17-7-5-16(6-8-17)21(27)11-14-25-29/h5-10,15,25,29H,11-14H2,1-4H3,(H,26,28)
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n/an/a>1.00E+5n/an/an/an/a7.2n/a



Shandong University



Assay Description
Briefly, the assay was performed in 96-well plates in 50 mm PBS, pH 7.2 as the assay buffer, at 37 C. The APN solution was mixed with compounds at v...


Chem Biol Drug Des 88: 542-55 (2016)


Article DOI: 10.1111/cbdd.12778
BindingDB Entry DOI: 10.7270/Q2HX1BHT
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM23971
PNG
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1
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n/an/a 6.25E+3n/an/an/an/a7.2n/a



Shandong University



Assay Description
IC50 values against APN were determined as previously described and by using L-Leu-p-nitroanilide as a substrate and microsomal aminopeptidase from P...


J Enzyme Inhib Med Chem 28: 717-26 (2013)


Article DOI: 10.3109/14756366.2012.680062
BindingDB Entry DOI: 10.7270/Q2930S39
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50061625
PNG
(4-[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthal...)
Show SMILES CC1(C)CCC(C)(C)c2cc(NC(=O)c3ccc(cc3)C(O)=O)ccc12
Show InChI InChI=1S/C22H25NO3/c1-21(2)11-12-22(3,4)18-13-16(9-10-17(18)21)23-19(24)14-5-7-15(8-6-14)20(25)26/h5-10,13H,11-12H2,1-4H3,(H,23,24)(H,25,26)
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n/an/a>1.00E+5n/an/an/an/a7.2n/a



Shandong University



Assay Description
Briefly, the assay was performed in 96-well plates in 50 mm PBS, pH 7.2 as the assay buffer, at 37 C. The APN solution was mixed with compounds at v...


Chem Biol Drug Des 88: 542-55 (2016)


Article DOI: 10.1111/cbdd.12778
BindingDB Entry DOI: 10.7270/Q2HX1BHT
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM23971
PNG
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1
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n/an/a 2.50E+3n/an/an/an/a7.2n/a



Shandong University



Assay Description
Briefly, the assay was performed in 96-well plates in 50 mm PBS, pH 7.2 as the assay buffer, at 37 C. The APN solution was mixed with compounds at v...


Chem Biol Drug Des 88: 542-55 (2016)


Article DOI: 10.1111/cbdd.12778
BindingDB Entry DOI: 10.7270/Q2HX1BHT
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Aminopeptidase N


(Sus scrofa (Pig))
BDBM19149
PNG
(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Show SMILES ONC(=O)CCCCCCC(=O)Nc1ccccc1
Show InChI InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)
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n/an/a>1.00E+5n/an/an/an/a7.2n/a



Shandong University



Assay Description
Briefly, the assay was performed in 96-well plates in 50 mm PBS, pH 7.2 as the assay buffer, at 37 C. The APN solution was mixed with compounds at v...


Chem Biol Drug Des 88: 542-55 (2016)


Article DOI: 10.1111/cbdd.12778
BindingDB Entry DOI: 10.7270/Q2HX1BHT
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM241972
PNG
(L-isoserine-L-phenylalanine-L-phenylalanine (16n))
Show SMILES NC[C@H](O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C21H25N3O5/c22-13-18(25)20(27)23-16(11-14-7-3-1-4-8-14)19(26)24-17(21(28)29)12-15-9-5-2-6-10-15/h1-10,16-18,25H,11-13,22H2,(H,23,27)(H,24,26)(H,28,29)/t16-,17-,18-/m0/s1
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n/an/a 6.50E+3n/an/an/an/a7.2n/a



Shandong University



Assay Description
IC50 values against APN were determined as previously described and by using L-Leu-p-nitroanilide as a substrate and microsomal aminopeptidase from P...


J Enzyme Inhib Med Chem 28: 717-26 (2013)


Article DOI: 10.3109/14756366.2012.680062
BindingDB Entry DOI: 10.7270/Q2930S39
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM241971
PNG
(L-isoserine-L-eucyl-L-tyrosinase (16m))
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)CN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C18H27N3O6/c1-10(2)7-13(20-17(25)15(23)9-19)16(24)21-14(18(26)27)8-11-3-5-12(22)6-4-11/h3-6,10,13-15,22-23H,7-9,19H2,1-2H3,(H,20,25)(H,21,24)(H,26,27)/t13-,14-,15-/m0/s1
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n/an/a 1.75E+4n/an/an/an/a7.2n/a



Shandong University



Assay Description
IC50 values against APN were determined as previously described and by using L-Leu-p-nitroanilide as a substrate and microsomal aminopeptidase from P...


J Enzyme Inhib Med Chem 28: 717-26 (2013)


Article DOI: 10.3109/14756366.2012.680062
BindingDB Entry DOI: 10.7270/Q2930S39
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM241970
PNG
(L-isoserine-L-tyrosinase-L-leucyl (16l))
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](O)CN)C(O)=O
Show InChI InChI=1S/C18H27N3O6/c1-10(2)7-14(18(26)27)21-16(24)13(20-17(25)15(23)9-19)8-11-3-5-12(22)6-4-11/h3-6,10,13-15,22-23H,7-9,19H2,1-2H3,(H,20,25)(H,21,24)(H,26,27)/t13-,14-,15-/m0/s1
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n/an/a 2.51E+3n/an/an/an/a7.2n/a



Shandong University



Assay Description
IC50 values against APN were determined as previously described and by using L-Leu-p-nitroanilide as a substrate and microsomal aminopeptidase from P...


J Enzyme Inhib Med Chem 28: 717-26 (2013)


Article DOI: 10.3109/14756366.2012.680062
BindingDB Entry DOI: 10.7270/Q2930S39
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM241969
PNG
(L-isoserine-L-phenylglycine-L-leucyl (16k))
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@@H](O)CN)c1ccccc1)C(O)=O
Show InChI InChI=1S/C17H25N3O5/c1-10(2)8-12(17(24)25)19-16(23)14(11-6-4-3-5-7-11)20-15(22)13(21)9-18/h3-7,10,12-14,21H,8-9,18H2,1-2H3,(H,19,23)(H,20,22)(H,24,25)/t12-,13-,14-/m0/s1
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n/an/a 1.16E+4n/an/an/an/a7.2n/a



Shandong University



Assay Description
IC50 values against APN were determined as previously described and by using L-Leu-p-nitroanilide as a substrate and microsomal aminopeptidase from P...


J Enzyme Inhib Med Chem 28: 717-26 (2013)


Article DOI: 10.3109/14756366.2012.680062
BindingDB Entry DOI: 10.7270/Q2930S39
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM241968
PNG
(L-isoserine-L-leucyl-L-valine (16i))
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)CN)C(=O)N[C@@H](C(C)C)C(O)=O
Show InChI InChI=1S/C14H27N3O5/c1-7(2)5-9(16-13(20)10(18)6-15)12(19)17-11(8(3)4)14(21)22/h7-11,18H,5-6,15H2,1-4H3,(H,16,20)(H,17,19)(H,21,22)/t9-,10-,11-/m0/s1
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n/an/a 5.16E+3n/an/an/an/a7.2n/a



Shandong University



Assay Description
IC50 values against APN were determined as previously described and by using L-Leu-p-nitroanilide as a substrate and microsomal aminopeptidase from P...


J Enzyme Inhib Med Chem 28: 717-26 (2013)


Article DOI: 10.3109/14756366.2012.680062
BindingDB Entry DOI: 10.7270/Q2930S39
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM241967
PNG
(L-isoserine-L-valine-L-leucyl (16h))
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@@H](O)CN)C(C)C)C(O)=O
Show InChI InChI=1S/C14H27N3O5/c1-7(2)5-9(14(21)22)16-13(20)11(8(3)4)17-12(19)10(18)6-15/h7-11,18H,5-6,15H2,1-4H3,(H,16,20)(H,17,19)(H,21,22)/t9-,10-,11-/m0/s1
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n/an/a 6.50E+3n/an/an/an/a7.2n/a



Shandong University



Assay Description
IC50 values against APN were determined as previously described and by using L-Leu-p-nitroanilide as a substrate and microsomal aminopeptidase from P...


J Enzyme Inhib Med Chem 28: 717-26 (2013)


Article DOI: 10.3109/14756366.2012.680062
BindingDB Entry DOI: 10.7270/Q2930S39
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM241966
PNG
(L-isoserine-L-phenylglycine-L-phenylalanine (16g))
Show SMILES NC[C@H](O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(O)=O)c1ccccc1
Show InChI InChI=1S/C20H23N3O5/c21-12-16(24)18(25)23-17(14-9-5-2-6-10-14)19(26)22-15(20(27)28)11-13-7-3-1-4-8-13/h1-10,15-17,24H,11-12,21H2,(H,22,26)(H,23,25)(H,27,28)/t15-,16-,17-/m0/s1
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n/an/a 5.80E+3n/an/an/an/a7.2n/a



Shandong University



Assay Description
IC50 values against APN were determined as previously described and by using L-Leu-p-nitroanilide as a substrate and microsomal aminopeptidase from P...


J Enzyme Inhib Med Chem 28: 717-26 (2013)


Article DOI: 10.3109/14756366.2012.680062
BindingDB Entry DOI: 10.7270/Q2930S39
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM241965
PNG
(L-isoserine-L-valine-L-valine (16f))
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](O)CN)C(C)C)C(O)=O
Show InChI InChI=1S/C13H25N3O5/c1-6(2)9(15-11(18)8(17)5-14)12(19)16-10(7(3)4)13(20)21/h6-10,17H,5,14H2,1-4H3,(H,15,18)(H,16,19)(H,20,21)/t8-,9-,10-/m0/s1
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n/an/a 1.36E+4n/an/an/an/a7.2n/a



Shandong University



Assay Description
IC50 values against APN were determined as previously described and by using L-Leu-p-nitroanilide as a substrate and microsomal aminopeptidase from P...


J Enzyme Inhib Med Chem 28: 717-26 (2013)


Article DOI: 10.3109/14756366.2012.680062
BindingDB Entry DOI: 10.7270/Q2930S39
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM241964
PNG
(L-isoserine-L-tyrosinase-L-valine (16e))
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](O)CN)C(O)=O
Show InChI InChI=1S/C17H25N3O6/c1-9(2)14(17(25)26)20-15(23)12(19-16(24)13(22)8-18)7-10-3-5-11(21)6-4-10/h3-6,9,12-14,21-22H,7-8,18H2,1-2H3,(H,19,24)(H,20,23)(H,25,26)/t12-,13-,14-/m0/s1
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n/an/a 1.15E+4n/an/an/an/a7.2n/a



Shandong University



Assay Description
IC50 values against APN were determined as previously described and by using L-Leu-p-nitroanilide as a substrate and microsomal aminopeptidase from P...


J Enzyme Inhib Med Chem 28: 717-26 (2013)


Article DOI: 10.3109/14756366.2012.680062
BindingDB Entry DOI: 10.7270/Q2930S39
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM241963
PNG
(L-isoserine-L-valine-L-phenylalanine (16d))
Show SMILES CC(C)[C@H](NC(=O)[C@@H](O)CN)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C17H25N3O5/c1-10(2)14(20-15(22)13(21)9-18)16(23)19-12(17(24)25)8-11-6-4-3-5-7-11/h3-7,10,12-14,21H,8-9,18H2,1-2H3,(H,19,23)(H,20,22)(H,24,25)/t12-,13-,14-/m0/s1
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n/an/a 3.02E+4n/an/an/an/a7.2n/a



Shandong University



Assay Description
IC50 values against APN were determined as previously described and by using L-Leu-p-nitroanilide as a substrate and microsomal aminopeptidase from P...


J Enzyme Inhib Med Chem 28: 717-26 (2013)


Article DOI: 10.3109/14756366.2012.680062
BindingDB Entry DOI: 10.7270/Q2930S39
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM241962
PNG
(L-isoserine-L-phenylglycine-L-valine (16c))
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](O)CN)c1ccccc1)C(O)=O
Show InChI InChI=1S/C16H23N3O5/c1-9(2)12(16(23)24)18-15(22)13(10-6-4-3-5-7-10)19-14(21)11(20)8-17/h3-7,9,11-13,20H,8,17H2,1-2H3,(H,18,22)(H,19,21)(H,23,24)/t11-,12-,13-/m0/s1
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n/an/a 5.15E+4n/an/an/an/a7.2n/a



Shandong University



Assay Description
IC50 values against APN were determined as previously described and by using L-Leu-p-nitroanilide as a substrate and microsomal aminopeptidase from P...


J Enzyme Inhib Med Chem 28: 717-26 (2013)


Article DOI: 10.3109/14756366.2012.680062
BindingDB Entry DOI: 10.7270/Q2930S39
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM241961
PNG
(L-isoserine-L-phenylalanine-L-valine (16b))
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](O)CN)C(O)=O
Show InChI InChI=1S/C17H25N3O5/c1-10(2)14(17(24)25)20-15(22)12(19-16(23)13(21)9-18)8-11-6-4-3-5-7-11/h3-7,10,12-14,21H,8-9,18H2,1-2H3,(H,19,23)(H,20,22)(H,24,25)/t12-,13-,14-/m0/s1
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n/an/a 9.40E+4n/an/an/an/a7.2n/a



Shandong University



Assay Description
IC50 values against APN were determined as previously described and by using L-Leu-p-nitroanilide as a substrate and microsomal aminopeptidase from P...


J Enzyme Inhib Med Chem 28: 717-26 (2013)


Article DOI: 10.3109/14756366.2012.680062
BindingDB Entry DOI: 10.7270/Q2930S39
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM241960
PNG
(2-[2-(3-amino-2-hydroxypropanamido)-3-phenylpropan...)
Show SMILES CCC(C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](O)CN)C(O)=O
Show InChI InChI=1S/C18H27N3O5/c1-3-11(2)15(18(25)26)21-16(23)13(20-17(24)14(22)10-19)9-12-7-5-4-6-8-12/h4-8,11,13-15,22H,3,9-10,19H2,1-2H3,(H,20,24)(H,21,23)(H,25,26)/t11?,13-,14-,15-/m0/s1
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n/an/a 3.04E+4n/an/an/an/a7.2n/a



Shandong University



Assay Description
IC50 values against APN were determined as previously described and by using L-Leu-p-nitroanilide as a substrate and microsomal aminopeptidase from P...


J Enzyme Inhib Med Chem 28: 717-26 (2013)


Article DOI: 10.3109/14756366.2012.680062
BindingDB Entry DOI: 10.7270/Q2930S39
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM23971
PNG
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1
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n/an/a 2.55E+3n/an/an/an/a7.525



Shan Dong University



Assay Description
IC50 values against APN from Porcine Kidney were determined by using L-Leu-p-nitroanilide as a substrate. All the solutions of the inhibitors were pr...


J Enzyme Inhib Med Chem 28: 545-51 (2013)


Article DOI: 10.3109/14756366.2012.656622
BindingDB Entry DOI: 10.7270/Q24J0D1S
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Aminopeptidase N


(Sus scrofa (Pig))
BDBM240812
PNG
((S)-2-((2R,3S)-3-amino-2-hydroxy-3-phenylpropanami...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](O)[C@@H](N)c1ccccc1)C(O)=O
Show InChI InChI=1S/C15H22N2O4/c1-9(2)8-11(15(20)21)17-14(19)13(18)12(16)10-6-4-3-5-7-10/h3-7,9,11-13,18H,8,16H2,1-2H3,(H,17,19)(H,20,21)/t11-,12-,13+/m0/s1
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n/an/a 3.52E+5n/an/an/an/a7.525



Shan Dong University



Assay Description
IC50 values against APN from Porcine Kidney were determined by using L-Leu-p-nitroanilide as a substrate. All the solutions of the inhibitors were pr...


J Enzyme Inhib Med Chem 28: 545-51 (2013)


Article DOI: 10.3109/14756366.2012.656622
BindingDB Entry DOI: 10.7270/Q24J0D1S
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM240831
PNG
((2R,3S)-3-amino-2-hydroxy-N-((S)-3-hydroxy-1-(hydr...)
Show SMILES N[C@H]([C@@H](O)C(=O)N[C@@H](CO)C(=O)NO)c1ccccc1
Show InChI InChI=1S/C12H17N3O5/c13-9(7-4-2-1-3-5-7)10(17)12(19)14-8(6-16)11(18)15-20/h1-5,8-10,16-17,20H,6,13H2,(H,14,19)(H,15,18)/t8-,9-,10+/m0/s1
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n/an/a 1.58E+5n/an/an/an/a7.525



Shan Dong University



Assay Description
IC50 values against APN from Porcine Kidney were determined by using L-Leu-p-nitroanilide as a substrate. All the solutions of the inhibitors were pr...


J Enzyme Inhib Med Chem 28: 545-51 (2013)


Article DOI: 10.3109/14756366.2012.656622
BindingDB Entry DOI: 10.7270/Q24J0D1S
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM240830
PNG
((2R,3S)-3-amino-2-hydroxy-N-((S)-1-(hydroxyamino)-...)
Show SMILES N[C@H]([C@@H](O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NO)c1ccccc1
Show InChI InChI=1S/C18H21N3O5/c19-15(12-4-2-1-3-5-12)16(23)18(25)20-14(17(24)21-26)10-11-6-8-13(22)9-7-11/h1-9,14-16,22-23,26H,10,19H2,(H,20,25)(H,21,24)/t14-,15-,16+/m0/s1
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n/an/a 1.73E+5n/an/an/an/a7.525



Shan Dong University



Assay Description
IC50 values against APN from Porcine Kidney were determined by using L-Leu-p-nitroanilide as a substrate. All the solutions of the inhibitors were pr...


J Enzyme Inhib Med Chem 28: 545-51 (2013)


Article DOI: 10.3109/14756366.2012.656622
BindingDB Entry DOI: 10.7270/Q24J0D1S
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM240829
PNG
((2R,3S)-3-amino-2-hydroxy-N-((S)-1-(hydroxyamino)-...)
Show SMILES N[C@H]([C@@H](O)C(=O)N[C@@H](Cc1ccccc1)C(=O)NO)c1ccccc1
Show InChI InChI=1S/C18H21N3O4/c19-15(13-9-5-2-6-10-13)16(22)18(24)20-14(17(23)21-25)11-12-7-3-1-4-8-12/h1-10,14-16,22,25H,11,19H2,(H,20,24)(H,21,23)/t14-,15-,16+/m0/s1
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n/an/a 4.40E+4n/an/an/an/a7.525



Shan Dong University



Assay Description
IC50 values against APN from Porcine Kidney were determined by using L-Leu-p-nitroanilide as a substrate. All the solutions of the inhibitors were pr...


J Enzyme Inhib Med Chem 28: 545-51 (2013)


Article DOI: 10.3109/14756366.2012.656622
BindingDB Entry DOI: 10.7270/Q24J0D1S
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM240828
PNG
((2R,3S)-3-amino-2-hydroxy-N-((S)-2-(hydroxyamino)-...)
Show SMILES N[C@H]([C@@H](O)C(=O)N[C@H](C(=O)NO)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C17H19N3O4/c18-13(11-7-3-1-4-8-11)15(21)17(23)19-14(16(22)20-24)12-9-5-2-6-10-12/h1-10,13-15,21,24H,18H2,(H,19,23)(H,20,22)/t13-,14-,15+/m0/s1
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n/an/a 1.26E+3n/an/an/an/a7.525



Shan Dong University



Assay Description
IC50 values against APN from Porcine Kidney were determined by using L-Leu-p-nitroanilide as a substrate. All the solutions of the inhibitors were pr...


J Enzyme Inhib Med Chem 28: 545-51 (2013)


Article DOI: 10.3109/14756366.2012.656622
BindingDB Entry DOI: 10.7270/Q24J0D1S
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM240827
PNG
((2S)-2-((2R,3S)-3-amino-2-hydroxy-3-phenylpropanam...)
Show SMILES CCC(C)[C@H](NC(=O)[C@H](O)[C@@H](N)c1ccccc1)C(=O)NO
Show InChI InChI=1S/C15H23N3O4/c1-3-9(2)12(14(20)18-22)17-15(21)13(19)11(16)10-7-5-4-6-8-10/h4-9,11-13,19,22H,3,16H2,1-2H3,(H,17,21)(H,18,20)/t9?,11-,12-,13+/m0/s1
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n/an/a 8.29E+4n/an/an/an/a7.525



Shan Dong University



Assay Description
IC50 values against APN from Porcine Kidney were determined by using L-Leu-p-nitroanilide as a substrate. All the solutions of the inhibitors were pr...


J Enzyme Inhib Med Chem 28: 545-51 (2013)


Article DOI: 10.3109/14756366.2012.656622
BindingDB Entry DOI: 10.7270/Q24J0D1S
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM240825
PNG
((S)-2-((2R,3S)-3-amino-2-hydroxy-3-phenylpropanami...)
Show SMILES CC(C)[C@H](NC(=O)[C@H](O)[C@@H](N)c1ccccc1)C(=O)NO
Show InChI InChI=1S/C14H21N3O4/c1-8(2)11(13(19)17-21)16-14(20)12(18)10(15)9-6-4-3-5-7-9/h3-8,10-12,18,21H,15H2,1-2H3,(H,16,20)(H,17,19)/t10-,11-,12+/m0/s1
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n/an/a 7.70E+4n/an/an/an/a7.525



Shan Dong University



Assay Description
IC50 values against APN from Porcine Kidney were determined by using L-Leu-p-nitroanilide as a substrate. All the solutions of the inhibitors were pr...


J Enzyme Inhib Med Chem 28: 545-51 (2013)


Article DOI: 10.3109/14756366.2012.656622
BindingDB Entry DOI: 10.7270/Q24J0D1S
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM240824
PNG
((S)-2-((2R,3S)-3-amino-2-hydroxy-3-phenylpropanami...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](O)[C@@H](N)c1ccccc1)C(=O)NO
Show InChI InChI=1S/C15H23N3O4/c1-9(2)8-11(14(20)18-22)17-15(21)13(19)12(16)10-6-4-3-5-7-10/h3-7,9,11-13,19,22H,8,16H2,1-2H3,(H,17,21)(H,18,20)/t11-,12-,13+/m0/s1
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n/an/a 5.67E+4n/an/an/an/a7.525



Shan Dong University



Assay Description
IC50 values against APN from Porcine Kidney were determined by using L-Leu-p-nitroanilide as a substrate. All the solutions of the inhibitors were pr...


J Enzyme Inhib Med Chem 28: 545-51 (2013)


Article DOI: 10.3109/14756366.2012.656622
BindingDB Entry DOI: 10.7270/Q24J0D1S
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM240823
PNG
((S)-2-((S)-2-((2R,3S)-3-amino-2-hydroxy-3-phenylpr...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](O)[C@@H](N)c1ccccc1)C(O)=O
Show InChI InChI=1S/C24H31N3O5/c1-15(2)13-19(24(31)32)27-22(29)18(14-16-9-5-3-6-10-16)26-23(30)21(28)20(25)17-11-7-4-8-12-17/h3-12,15,18-21,28H,13-14,25H2,1-2H3,(H,26,30)(H,27,29)(H,31,32)/t18-,19-,20-,21+/m0/s1
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n/an/a 1.05E+5n/an/an/an/a7.525



Shan Dong University



Assay Description
IC50 values against APN from Porcine Kidney were determined by using L-Leu-p-nitroanilide as a substrate. All the solutions of the inhibitors were pr...


J Enzyme Inhib Med Chem 28: 545-51 (2013)


Article DOI: 10.3109/14756366.2012.656622
BindingDB Entry DOI: 10.7270/Q24J0D1S
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM240821
PNG
((S)-2-((S)-2-((2R,3S)-3-amino-2-hydroxy-3-phenylpr...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](O)[C@@H](N)c1ccccc1)C(O)=O
Show InChI InChI=1S/C21H33N3O5/c1-12(2)10-15(19(26)24-16(21(28)29)11-13(3)4)23-20(27)18(25)17(22)14-8-6-5-7-9-14/h5-9,12-13,15-18,25H,10-11,22H2,1-4H3,(H,23,27)(H,24,26)(H,28,29)/t15-,16-,17-,18+/m0/s1
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n/an/a 5.13E+5n/an/an/an/a7.525



Shan Dong University



Assay Description
IC50 values against APN from Porcine Kidney were determined by using L-Leu-p-nitroanilide as a substrate. All the solutions of the inhibitors were pr...


J Enzyme Inhib Med Chem 28: 545-51 (2013)


Article DOI: 10.3109/14756366.2012.656622
BindingDB Entry DOI: 10.7270/Q24J0D1S
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM240820
PNG
((S)-2-((S)-2-((2R,3S)-3-amino-2-hydroxy-3-phenylpr...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](O)[C@@H](N)c1ccccc1)C(=O)N[C@@H](C(C)C)C(O)=O
Show InChI InChI=1S/C20H31N3O5/c1-11(2)10-14(18(25)23-16(12(3)4)20(27)28)22-19(26)17(24)15(21)13-8-6-5-7-9-13/h5-9,11-12,14-17,24H,10,21H2,1-4H3,(H,22,26)(H,23,25)(H,27,28)/t14-,15-,16-,17+/m0/s1
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n/an/a 5.90E+5n/an/an/an/a7.525



Shan Dong University



Assay Description
IC50 values against APN from Porcine Kidney were determined by using L-Leu-p-nitroanilide as a substrate. All the solutions of the inhibitors were pr...


J Enzyme Inhib Med Chem 28: 545-51 (2013)


Article DOI: 10.3109/14756366.2012.656622
BindingDB Entry DOI: 10.7270/Q24J0D1S
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM240816
PNG
((S)-2-((2R,3S)-3-amino-2-hydroxy-3-phenylpropanami...)
Show SMILES N[C@H]([C@@H](O)C(=O)N[C@H](C(O)=O)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C17H18N2O4/c18-13(11-7-3-1-4-8-11)15(20)16(21)19-14(17(22)23)12-9-5-2-6-10-12/h1-10,13-15,20H,18H2,(H,19,21)(H,22,23)/t13-,14-,15+/m0/s1
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n/an/a 1.98E+5n/an/an/an/a7.525



Shan Dong University



Assay Description
IC50 values against APN from Porcine Kidney were determined by using L-Leu-p-nitroanilide as a substrate. All the solutions of the inhibitors were pr...


J Enzyme Inhib Med Chem 28: 545-51 (2013)


Article DOI: 10.3109/14756366.2012.656622
BindingDB Entry DOI: 10.7270/Q24J0D1S
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM240814
PNG
((S)-2-((2R,3S)-3-amino-2-hydroxy-3-phenylpropanami...)
Show SMILES C[C@H](NC(=O)[C@H](O)[C@@H](N)c1ccccc1)C(O)=O
Show InChI InChI=1S/C12H16N2O4/c1-7(12(17)18)14-11(16)10(15)9(13)8-5-3-2-4-6-8/h2-7,9-10,15H,13H2,1H3,(H,14,16)(H,17,18)/t7-,9-,10+/m0/s1
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n/an/a 3.42E+5n/an/an/an/a7.525



Shan Dong University



Assay Description
IC50 values against APN from Porcine Kidney were determined by using L-Leu-p-nitroanilide as a substrate. All the solutions of the inhibitors were pr...


J Enzyme Inhib Med Chem 28: 545-51 (2013)


Article DOI: 10.3109/14756366.2012.656622
BindingDB Entry DOI: 10.7270/Q24J0D1S
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM240832
PNG
((S)-2-((2R,3S)-3-amino-2-hydroxy-3-phenylpropanami...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](O)[C@@H](N)c1ccccc1)C(=O)Nc1ccccc1C
Show InChI InChI=1S/C22H29N3O3/c1-14(2)13-18(21(27)24-17-12-8-7-9-15(17)3)25-22(28)20(26)19(23)16-10-5-4-6-11-16/h4-12,14,18-20,26H,13,23H2,1-3H3,(H,24,27)(H,25,28)/t18-,19-,20+/m0/s1
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n/an/a 3.63E+5n/an/an/an/a7.525



Shan Dong University



Assay Description
IC50 values against APN from Porcine Kidney were determined by using L-Leu-p-nitroanilide as a substrate. All the solutions of the inhibitors were pr...


J Enzyme Inhib Med Chem 28: 545-51 (2013)


Article DOI: 10.3109/14756366.2012.656622
BindingDB Entry DOI: 10.7270/Q24J0D1S
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50078120
PNG
((R)-1-{[(S)-2-((S)-1-Carboxy-1-methyl-2-phenyl-eth...)
Show SMILES C[C@H]([NH3+])P(O)(=O)C[C@@H](Cc1ccccc1)C(=O)N[C@@](C)(Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C22H29N2O5P/c1-16(23)30(28,29)15-19(13-17-9-5-3-6-10-17)20(25)24-22(2,21(26)27)14-18-11-7-4-8-12-18/h3-12,16,19H,13-15,23H2,1-2H3,(H,24,25)(H,26,27)(H,28,29)/p+1/t16-,19-,22+/m1/s1
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0n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibitory activity was measured on pig kidney Aminopeptidase N (activity for C+D stereoisomer)


Bioorg Med Chem Lett 9: 1511-6 (1999)


Article DOI: 10.1016/s0960-894x(99)00236-x
BindingDB Entry DOI: 10.7270/Q2H132JR
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50078122
PNG
((R)-1-{[(S)-2-((S)-1-Carboxy-1-methyl-2-phenyl-eth...)
Show SMILES C[C@@](Cc1ccccc1)(NC(=O)[C@H](Cc1ccccc1)CP(O)(=O)[C@@H]([NH3+])Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C28H33N2O5P/c1-28(27(32)33,19-23-15-9-4-10-16-23)30-26(31)24(17-21-11-5-2-6-12-21)20-36(34,35)25(29)18-22-13-7-3-8-14-22/h2-16,24-25H,17-20,29H2,1H3,(H,30,31)(H,32,33)(H,34,35)/p+1/t24-,25-,28+/m1/s1
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0n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibitory activity was measured on pig kidney Aminopeptidase N (activity for C+D stereoisomer)


Bioorg Med Chem Lett 9: 1511-6 (1999)


Article DOI: 10.1016/s0960-894x(99)00236-x
BindingDB Entry DOI: 10.7270/Q2H132JR
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50353018
PNG
(CHEMBL1821980 | CHEMBL1852660)
Show SMILES NC1CCc2c(Br)ccc(-c3ccccc3)c2CC1=O
Show InChI InChI=1S/C17H16BrNO/c18-15-8-6-12(11-4-2-1-3-5-11)14-10-17(20)16(19)9-7-13(14)15/h1-6,8,16H,7,9-10,19H2
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0.0600n/an/an/an/an/an/an/an/a



Universit£ de Haute Alsace

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney APN using L-leucine-p-nitroanilide as substrate after 30 mins by Dixon plot analysis


Bioorg Med Chem 19: 5716-33 (2011)


Article DOI: 10.1016/j.bmc.2011.06.089
BindingDB Entry DOI: 10.7270/Q2805307
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50353018
PNG
(CHEMBL1821980 | CHEMBL1852660)
Show SMILES NC1CCc2c(Br)ccc(-c3ccccc3)c2CC1=O
Show InChI InChI=1S/C17H16BrNO/c18-15-8-6-12(11-4-2-1-3-5-11)14-10-17(20)16(19)9-7-13(14)15/h1-6,8,16H,7,9-10,19H2
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0.0600n/an/an/an/an/an/an/an/a



Universit£ de Haute-Alsace

Curated by ChEMBL


Assay Description
Inhibition of pig APN using L-leucine-p-nitroanilide as substrate measured every 10 mins for 2 hrs by spectriphotometric analysis


Bioorg Med Chem 21: 2135-44 (2013)


Article DOI: 10.1016/j.bmc.2012.12.038
BindingDB Entry DOI: 10.7270/Q2CZ38J9
More data for this
Ligand-Target Pair
Aminopeptidase N


(Mus musculus)
BDBM50353018
PNG
(CHEMBL1821980 | CHEMBL1852660)
Show SMILES NC1CCc2c(Br)ccc(-c3ccccc3)c2CC1=O
Show InChI InChI=1S/C17H16BrNO/c18-15-8-6-12(11-4-2-1-3-5-11)14-10-17(20)16(19)9-7-13(14)15/h1-6,8,16H,7,9-10,19H2
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0.200n/an/an/an/an/an/an/an/a



Universit£ de Haute-Alsace

Curated by ChEMBL


Assay Description
Inhibition of mouse APN using L-leucine-p-nitroanilide as substrate measured every 10 mins for 2 hrs by spectriphotometric analysis


Bioorg Med Chem 21: 2135-44 (2013)


Article DOI: 10.1016/j.bmc.2012.12.038
BindingDB Entry DOI: 10.7270/Q2CZ38J9
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM23971
PNG
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1
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0.5n/an/an/an/an/an/an/an/a



Universit£ de Haute Alsace

Curated by ChEMBL


Assay Description
Competitive inhibition of pig APN using L-leucine-p-nitroanilide as substrate by Dixon-plot analysis


Bioorg Med Chem 20: 4942-53 (2012)


Article DOI: 10.1016/j.bmc.2012.06.041
BindingDB Entry DOI: 10.7270/Q2RB75Q1
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50078125
PNG
((1-Amino-3-phenyl-propyl)-phosphinic acid | CHEMBL...)
Show SMILES OP(O)C(=N)CCc1ccccc1
Show InChI InChI=1S/C9H12NO2P/c10-9(13(11)12)7-6-8-4-2-1-3-5-8/h1-5,10-12H,6-7H2
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1.20n/an/an/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of pig recombinant alanyl aminopeptidase after 30 to 60 mins by morrison's equation


J Med Chem 57: 8140-51 (2014)


Article DOI: 10.1021/jm501071f
BindingDB Entry DOI: 10.7270/Q2CF9RQF
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50025070
PNG
(CHEMBL3355110)
Show SMILES NCc1ccc(CC(CP(O)(=O)C(N)CCc2cccnc2)C(O)=O)cc1
Show InChI InChI=1S/C19H26N3O4P/c20-11-15-5-3-14(4-6-15)10-17(19(23)24)13-27(25,26)18(21)8-7-16-2-1-9-22-12-16/h1-6,9,12,17-18H,7-8,10-11,13,20-21H2,(H,23,24)(H,25,26)
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1.5n/an/an/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of pig recombinant alanyl aminopeptidase after 30 to 60 mins by morrison's equation


J Med Chem 57: 8140-51 (2014)


Article DOI: 10.1021/jm501071f
BindingDB Entry DOI: 10.7270/Q2CF9RQF
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50087089
PNG
((2S)-2-[(2S)-3-{[(1S)-1-azaniumyl-2-phenylethyl](h...)
Show SMILES [NH3+][C@H](Cc1ccccc1)P(O)(=O)C[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C27H31N2O5P/c28-25(18-22-14-8-3-9-15-22)35(33,34)19-23(16-20-10-4-1-5-11-20)26(30)29-24(27(31)32)17-21-12-6-2-7-13-21/h1-15,23-25H,16-19,28H2,(H,29,30)(H,31,32)(H,33,34)/p+1/t23-,24+,25+/m1/s1
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1.5n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibitory activity on aminopeptidase N (APN) using Ala-pNA as substrate.


J Med Chem 43: 1398-408 (2001)


Article DOI: 10.1021/jm990483l
BindingDB Entry DOI: 10.7270/Q2TQ627J
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50393210
PNG
(CHEMBL1235787)
Show SMILES CC(=N)P(O)(O)C[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C21H27N2O5P/c1-15(22)29(27,28)14-18(12-16-8-4-2-5-9-16)20(24)23-19(21(25)26)13-17-10-6-3-7-11-17/h2-11,18-19,22,27-29H,12-14H2,1H3,(H,23,24)(H,25,26)/t18-,19+/m1/s1
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1.5n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of porcine APN


Bioorg Med Chem Lett 26: 4122-6 (2016)


Article DOI: 10.1016/j.bmcl.2016.06.062
BindingDB Entry DOI: 10.7270/Q2TT4SW1
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50087095
PNG
(1-{[3-(4-Bromo-phenyl)-2-(1-carboxy-ethylcarbamoyl...)
Show SMILES C[C@@H]([NH3+])P(O)(=O)C[C@@H](Cc1ccc(Br)cc1)C(=O)N[C@@H](C)C(O)=O
Show InChI InChI=1S/C15H22BrN2O5P/c1-9(15(20)21)18-14(19)12(8-24(22,23)10(2)17)7-11-3-5-13(16)6-4-11/h3-6,9-10,12H,7-8,17H2,1-2H3,(H,18,19)(H,20,21)(H,22,23)/p+1/t9-,10-,12+/m0/s1
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1.90n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibitory activity on aminopeptidase N (APN) using Ala-pNA as substrate.


J Med Chem 43: 1398-408 (2001)


Article DOI: 10.1021/jm990483l
BindingDB Entry DOI: 10.7270/Q2TQ627J
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50105574
PNG
(CHEMBL3597443)
Show SMILES NC1CCc2cccc(-c3ccc(Cl)cc3)c2CC1=O
Show InChI InChI=1S/C17H16ClNO.ClH/c18-13-7-4-12(5-8-13)14-3-1-2-11-6-9-16(19)17(20)10-15(11)14;/h1-5,7-8,16H,6,9-10,19H2;1H
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2n/an/an/an/an/an/an/an/a



Universit£ de Haute Alsace

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney APN assessed as decrease in p-nitroanilide release using L-leucine-p-nitroanilide as substrate by spectrophotometric ana...


Bioorg Med Chem 23: 3192-207 (2015)


Article DOI: 10.1016/j.bmc.2015.04.066
BindingDB Entry DOI: 10.7270/Q2Z321DW
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50087097
PNG
(1-{[2-(1-Carboxy-2-phenyl-ethylcarbamoyl)-3-phenyl...)
Show SMILES CC([NH3+])P(O)(=O)C[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C21H27N2O5P/c1-15(22)29(27,28)14-18(12-16-8-4-2-5-9-16)20(24)23-19(21(25)26)13-17-10-6-3-7-11-17/h2-11,15,18-19H,12-14,22H2,1H3,(H,23,24)(H,25,26)(H,27,28)/p+1/t15?,18-,19+/m1/s1
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2.20n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibitory activity on aminopeptidase N (APN) using Ala-pNA as substrate.


J Med Chem 43: 1398-408 (2001)


Article DOI: 10.1021/jm990483l
BindingDB Entry DOI: 10.7270/Q2TQ627J
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50087097
PNG
(1-{[2-(1-Carboxy-2-phenyl-ethylcarbamoyl)-3-phenyl...)
Show SMILES CC([NH3+])P(O)(=O)C[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C21H27N2O5P/c1-15(22)29(27,28)14-18(12-16-8-4-2-5-9-16)20(24)23-19(21(25)26)13-17-10-6-3-7-11-17/h2-11,15,18-19H,12-14,22H2,1H3,(H,23,24)(H,25,26)(H,27,28)/p+1/t15?,18-,19+/m1/s1
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2.20n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibitory activity was measured on pig kidney Aminopeptidase N (activity for A+B stereoisomer)


Bioorg Med Chem Lett 9: 1511-6 (1999)


Article DOI: 10.1016/s0960-894x(99)00236-x
BindingDB Entry DOI: 10.7270/Q2H132JR
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50087093
PNG
(1-{[2-(1-Carboxy-2-phenyl-ethylcarbamoyl)-3-phenyl...)
Show SMILES CCC([NH3+])P(O)(=O)C[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C22H29N2O5P/c1-2-20(23)30(28,29)15-18(13-16-9-5-3-6-10-16)21(25)24-19(22(26)27)14-17-11-7-4-8-12-17/h3-12,18-20H,2,13-15,23H2,1H3,(H,24,25)(H,26,27)(H,28,29)/p+1/t18-,19+,20?/m1/s1
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2.30n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibitory activity on aminopeptidase N (APN) using Ala-pNA as substrate.


J Med Chem 43: 1398-408 (2001)


Article DOI: 10.1021/jm990483l
BindingDB Entry DOI: 10.7270/Q2TQ627J
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50087084
PNG
(1-{[2-(1-Carboxy-2-phenyl-ethylcarbamoyl)-3-phenyl...)
Show SMILES [NH3+]C(CCc1ccccc1)P(O)(=O)C[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C28H33N2O5P/c29-26(17-16-21-10-4-1-5-11-21)36(34,35)20-24(18-22-12-6-2-7-13-22)27(31)30-25(28(32)33)19-23-14-8-3-9-15-23/h1-15,24-26H,16-20,29H2,(H,30,31)(H,32,33)(H,34,35)/p+1/t24-,25+,26?/m1/s1
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2.30n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibitory activity on aminopeptidase N (APN) using Ala-pNA as substrate.


J Med Chem 43: 1398-408 (2001)


Article DOI: 10.1021/jm990483l
BindingDB Entry DOI: 10.7270/Q2TQ627J
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50087094
PNG
((R,S,S)1-{[2-(1-Carboxy-2-phenyl-ethylcarbamoyl)-4...)
Show SMILES CC(C)C[C@H](CP(O)(=O)[C@H]([NH3+])Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C24H33N2O5P/c1-17(2)13-20(16-32(30,31)22(25)15-19-11-7-4-8-12-19)23(27)26-21(24(28)29)14-18-9-5-3-6-10-18/h3-12,17,20-22H,13-16,25H2,1-2H3,(H,26,27)(H,28,29)(H,30,31)/p+1/t20-,21+,22+/m1/s1
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2.30n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibitory activity on aminopeptidase N (APN) using Ala-pNA as substrate.


J Med Chem 43: 1398-408 (2001)


Article DOI: 10.1021/jm990483l
BindingDB Entry DOI: 10.7270/Q2TQ627J
More data for this
Ligand-Target Pair
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