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Compile Data Set for Download or QSAR

Found 1995 hits Enz. Inhib. hit(s) with Target = 'Apelin receptor'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Apelin receptor


(Homo sapiens)
BDBM269939
PNG
((3R,5S)—N-(4-(2,6-dimethoxyphenyl)-5-(6-metho...)
Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H]2C[C@H](O)CN(C2)c2ncc(F)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C25H27FN8O6S/c1-38-19-7-5-8-20(39-2)22(19)34-23(18-6-4-9-21(29-18)40-3)30-31-25(34)32-41(36,37)17-10-16(35)13-33(14-17)24-27-11-15(26)12-28-24/h4-9,11-12,16-17,35H,10,13-14H2,1-3H3,(H,31,32)/t16-,17+/m0/s1
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n/an/an/an/a 0.730n/an/a7.5n/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269940
PNG
((1R,2S)-1-(2,4-dicyanophenyl)-N-(4-(2,6-dimethoxyp...)
Show SMILES COc1ccc(CN(Cc2ccc(OC)cc2)S(=O)(=O)[C@H](C)[C@@H](O)c2ccc(Br)cc2Br)cc1
Show InChI InChI=1S/C25H27Br2NO5S/c1-17(25(29)23-13-8-20(26)14-24(23)27)34(30,31)28(15-18-4-9-21(32-2)10-5-18)16-19-6-11-22(33-3)12-7-19/h4-14,17,25,29H,15-16H2,1-3H3/t17-,25-/m1/s1
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n/an/an/an/a 0.230n/an/a7.5n/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269941
PNG
((1R,2S)-1-(2,4-dicyanophenyl)-N-(4-(2,6-dimethoxyp...)
Show SMILES CO[C@H]([C@@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ccc(cc1C#N)C#N
Show InChI InChI=1S/C28H27N7O6S/c1-17(26(41-5)20-13-12-18(15-29)14-19(20)16-30)42(36,37)34-28-33-32-27(21-8-6-11-24(31-21)40-4)35(28)25-22(38-2)9-7-10-23(25)39-3/h6-14,17,26H,1-5H3,(H,33,34)/t17-,26-/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269941
PNG
((1R,2S)-1-(2,4-dicyanophenyl)-N-(4-(2,6-dimethoxyp...)
Show SMILES CO[C@H]([C@@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ccc(cc1C#N)C#N
Show InChI InChI=1S/C28H27N7O6S/c1-17(26(41-5)20-13-12-18(15-29)14-19(20)16-30)42(36,37)34-28-33-32-27(21-8-6-11-24(31-21)40-4)35(28)25-22(38-2)9-7-10-23(25)39-3/h6-14,17,26H,1-5H3,(H,33,34)/t17-,26-/m1/s1
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n/an/an/an/a 27n/an/a7.5n/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269943
PNG
((1R,2R)-1-(2,4-dicyanophenyl)-N-(4-(2,6-dimethoxyp...)
Show SMILES CO[C@@H]([C@@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ccc(cc1C#N)C#N
Show InChI InChI=1S/C28H27N7O6S/c1-17(26(41-5)20-13-12-18(15-29)14-19(20)16-30)42(36,37)34-28-33-32-27(21-8-6-11-24(31-21)40-4)35(28)25-22(38-2)9-7-10-23(25)39-3/h6-14,17,26H,1-5H3,(H,33,34)/t17-,26+/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269943
PNG
((1R,2R)-1-(2,4-dicyanophenyl)-N-(4-(2,6-dimethoxyp...)
Show SMILES CO[C@@H]([C@@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ccc(cc1C#N)C#N
Show InChI InChI=1S/C28H27N7O6S/c1-17(26(41-5)20-13-12-18(15-29)14-19(20)16-30)42(36,37)34-28-33-32-27(21-8-6-11-24(31-21)40-4)35(28)25-22(38-2)9-7-10-23(25)39-3/h6-14,17,26H,1-5H3,(H,33,34)/t17-,26+/m1/s1
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n/an/an/an/a 16n/an/a7.5n/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269945
PNG
((1R,2S)-1-(2,4-dicyanophenyl)-N-(4-(2,6-dimethoxyp...)
Show SMILES CO[C@H]([C@@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC)c1ccc(cc1C#N)C#N
Show InChI InChI=1S/C28H27N7O5S/c1-17-11-21(16-31-15-17)27-32-33-28(35(27)25-23(38-3)7-6-8-24(25)39-4)34-41(36,37)18(2)26(40-5)22-10-9-19(13-29)12-20(22)14-30/h6-12,15-16,18,26H,1-5H3,(H,33,34)/t18-,26-/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269946
PNG
((1R,2S)-1-(2,4-dicyanophenyl)-N-(4-(2,6-dimethoxyp...)
Show SMILES CO[C@H]([C@@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC)c1ccc(cc1C#N)C#N
Show InChI InChI=1S/C28H27N7O5S/c1-17-11-21(16-31-15-17)27-32-33-28(35(27)25-23(38-3)7-6-8-24(25)39-4)34-41(36,37)18(2)26(40-5)22-10-9-19(13-29)12-20(22)14-30/h6-12,15-16,18,26H,1-5H3,(H,33,34)/t18-,26-/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269946
PNG
((1R,2S)-1-(2,4-dicyanophenyl)-N-(4-(2,6-dimethoxyp...)
Show SMILES CO[C@H]([C@@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC)c1ccc(cc1C#N)C#N
Show InChI InChI=1S/C28H27N7O5S/c1-17-11-21(16-31-15-17)27-32-33-28(35(27)25-23(38-3)7-6-8-24(25)39-4)34-41(36,37)18(2)26(40-5)22-10-9-19(13-29)12-20(22)14-30/h6-12,15-16,18,26H,1-5H3,(H,33,34)/t18-,26-/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269948
PNG
((2S)-2-(4-cyano-2-(methylsulfonyl)phenyl)-N-(4-(2,...)
Show SMILES COc1cccc(n1)-c1nnc(N(CC[Si](C)(C)C)S(=O)(=O)C[C@@H](O)c2ccc(Cl)cc2S(C)(=O)=O)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C30H38ClN5O8S2Si/c1-42-24-11-9-12-25(43-2)28(24)36-29(22-10-8-13-27(32-22)44-3)33-34-30(36)35(16-17-47(5,6)7)46(40,41)19-23(37)21-15-14-20(31)18-26(21)45(4,38)39/h8-15,18,23,37H,16-17,19H2,1-7H3/t23-/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269949
PNG
((2S)-2-(4-cyano-2-(methylsulfonyl)phenyl)-N-(4-(2,...)
Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)C[C@@H](O)c2ccc(cc2S(C)(=O)=O)C#N)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C26H26N6O8S2/c1-38-20-8-6-9-21(39-2)24(20)32-25(18-7-5-10-23(28-18)40-3)29-30-26(32)31-42(36,37)15-19(33)17-12-11-16(14-27)13-22(17)41(4,34)35/h5-13,19,33H,15H2,1-4H3,(H,30,31)/t19-/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269949
PNG
((2S)-2-(4-cyano-2-(methylsulfonyl)phenyl)-N-(4-(2,...)
Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)C[C@@H](O)c2ccc(cc2S(C)(=O)=O)C#N)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C26H26N6O8S2/c1-38-20-8-6-9-21(39-2)24(20)32-25(18-7-5-10-23(28-18)40-3)29-30-26(32)31-42(36,37)15-19(33)17-12-11-16(14-27)13-22(17)41(4,34)35/h5-13,19,33H,15H2,1-4H3,(H,30,31)/t19-/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269951
PNG
((2R)-2-(4-cyano-2-(methylsulfonyl)phenyl)-N-(4-(2,...)
Show SMILES CO[C@H](CS(=O)(=O)N(CC[Si](C)(C)C)c1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ccc(cc1S(C)(=O)=O)C#N
Show InChI InChI=1S/C32H40N6O8S2Si/c1-43-25-12-10-13-26(44-2)30(25)38-31(24-11-9-14-29(34-24)46-4)35-36-32(38)37(17-18-49(6,7)8)48(41,42)21-27(45-3)23-16-15-22(20-33)19-28(23)47(5,39)40/h9-16,19,27H,17-18,21H2,1-8H3/t27-/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269952
PNG
((2R)-2-(4-cyano-2-(methylsulfonyl)phenyl)-N-(4-(2,...)
Show SMILES CO[C@H](CS(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ccc(cc1S(C)(=O)=O)C#N
Show InChI InChI=1S/C27H28N6O8S2/c1-38-20-9-7-10-21(39-2)25(20)33-26(19-8-6-11-24(29-19)41-4)30-31-27(33)32-43(36,37)16-22(40-3)18-13-12-17(15-28)14-23(18)42(5,34)35/h6-14,22H,16H2,1-5H3,(H,31,32)/t22-/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269952
PNG
((2R)-2-(4-cyano-2-(methylsulfonyl)phenyl)-N-(4-(2,...)
Show SMILES CO[C@H](CS(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ccc(cc1S(C)(=O)=O)C#N
Show InChI InChI=1S/C27H28N6O8S2/c1-38-20-9-7-10-21(39-2)25(20)33-26(19-8-6-11-24(29-19)41-4)30-31-27(33)32-43(36,37)16-22(40-3)18-13-12-17(15-28)14-23(18)42(5,34)35/h6-14,22H,16H2,1-5H3,(H,31,32)/t22-/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269954
PNG
((2R)—N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-...)
Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)C[C@@H](O)c2cnc(C)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C23H25N7O6S/c1-14-11-25-16(12-24-14)17(31)13-37(32,33)29-23-28-27-22(15-7-5-10-20(26-15)36-4)30(23)21-18(34-2)8-6-9-19(21)35-3/h5-12,17,31H,13H2,1-4H3,(H,28,29)/t17-/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269954
PNG
((2R)—N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-...)
Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)C[C@@H](O)c2cnc(C)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C23H25N7O6S/c1-14-11-25-16(12-24-14)17(31)13-37(32,33)29-23-28-27-22(15-7-5-10-20(26-15)36-4)30(23)21-18(34-2)8-6-9-19(21)35-3/h5-12,17,31H,13H2,1-4H3,(H,28,29)/t17-/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269956
PNG
((2R)-2-(4-cyano-2-(methylsulfonyl)phenyl)-N-(4-(2,...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)C[C@H](O)c2ccc(cc2S(C)(=O)=O)C#N)nnc1-c1cncc(C)c1
Show InChI InChI=1S/C26H26N6O7S2/c1-16-10-18(14-28-13-16)25-29-30-26(32(25)24-21(38-2)6-5-7-22(24)39-3)31-41(36,37)15-20(33)19-9-8-17(12-27)11-23(19)40(4,34)35/h5-11,13-14,20,33H,15H2,1-4H3,(H,30,31)/t20-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269956
PNG
((2R)-2-(4-cyano-2-(methylsulfonyl)phenyl)-N-(4-(2,...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)C[C@H](O)c2ccc(cc2S(C)(=O)=O)C#N)nnc1-c1cncc(C)c1
Show InChI InChI=1S/C26H26N6O7S2/c1-16-10-18(14-28-13-16)25-29-30-26(32(25)24-21(38-2)6-5-7-22(24)39-3)31-41(36,37)15-20(33)19-9-8-17(12-27)11-23(19)40(4,34)35/h5-11,13-14,20,33H,15H2,1-4H3,(H,30,31)/t20-/m0/s1
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n/an/an/an/a 0.610n/an/a7.5n/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269958
PNG
((2R)—N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-...)
Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)C[C@@H](O)c2cnc(C)nc2)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C23H25N7O6S/c1-14-24-11-15(12-25-14)17(31)13-37(32,33)29-23-28-27-22(16-7-5-10-20(26-16)36-4)30(23)21-18(34-2)8-6-9-19(21)35-3/h5-12,17,31H,13H2,1-4H3,(H,28,29)/t17-/m1/s1
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n/an/an/an/a 2.80n/an/a7.5n/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269873
PNG
((1S,2R)—N-(4-(2,6-dimethoxyphenyl)-5-(5-methy...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](OC[C@H](C)O)c2ncc(C)cn2)nnc1-c1cncc(C)c1
Show InChI InChI=1S/C27H33N7O6S/c1-16-10-20(14-28-11-16)26-31-32-27(34(26)23-21(38-5)8-7-9-22(23)39-6)33-41(36,37)19(4)24(40-15-18(3)35)25-29-12-17(2)13-30-25/h7-14,18-19,24,35H,15H2,1-6H3,(H,32,33)/t18-,19-,24-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269873
PNG
((1S,2R)—N-(4-(2,6-dimethoxyphenyl)-5-(5-methy...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](OC[C@H](C)O)c2ncc(C)cn2)nnc1-c1cncc(C)c1
Show InChI InChI=1S/C27H33N7O6S/c1-16-10-20(14-28-11-16)26-31-32-27(34(26)23-21(38-5)8-7-9-22(23)39-6)33-41(36,37)19(4)24(40-15-18(3)35)25-29-12-17(2)13-30-25/h7-14,18-19,24,35H,15H2,1-6H3,(H,32,33)/t18-,19-,24-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269877
PNG
((1S,2R)—N-(4-(2,6-dimethoxyphenyl)-5-(5-methy...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](OCC(C)(C)O)c2ncc(C)cn2)nnc1-c1cncc(C)c1
Show InChI InChI=1S/C28H35N7O6S/c1-17-11-20(15-29-12-17)26-32-33-27(35(26)23-21(39-6)9-8-10-22(23)40-7)34-42(37,38)19(3)24(41-16-28(4,5)36)25-30-13-18(2)14-31-25/h8-15,19,24,36H,16H2,1-7H3,(H,33,34)/t19-,24-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269877
PNG
((1S,2R)—N-(4-(2,6-dimethoxyphenyl)-5-(5-methy...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](OCC(C)(C)O)c2ncc(C)cn2)nnc1-c1cncc(C)c1
Show InChI InChI=1S/C28H35N7O6S/c1-17-11-20(15-29-12-17)26-32-33-27(35(26)23-21(39-6)9-8-10-22(23)40-7)34-42(37,38)19(3)24(41-16-28(4,5)36)25-30-13-18(2)14-31-25/h8-15,19,24,36H,16H2,1-7H3,(H,33,34)/t19-,24-/m0/s1
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n/an/an/an/a 39n/an/a7.5n/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269879
PNG
((1S,2S)—N-(4-(2,6-dimethoxyphenyl)-5-(5-methy...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)[C@H](OCCO)c2ncc(C)cn2)nnc1-c1cncc(C)c1
Show InChI InChI=1S/C26H31N7O6S/c1-16-11-19(15-27-12-16)25-30-31-26(33(25)22-20(37-4)7-6-8-21(22)38-5)32-40(35,36)18(3)23(39-10-9-34)24-28-13-17(2)14-29-24/h6-8,11-15,18,23,34H,9-10H2,1-5H3,(H,31,32)/t18-,23+/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269879
PNG
((1S,2S)—N-(4-(2,6-dimethoxyphenyl)-5-(5-methy...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)[C@H](OCCO)c2ncc(C)cn2)nnc1-c1cncc(C)c1
Show InChI InChI=1S/C26H31N7O6S/c1-16-11-19(15-27-12-16)25-30-31-26(33(25)22-20(37-4)7-6-8-21(22)38-5)32-40(35,36)18(3)23(39-10-9-34)24-28-13-17(2)14-29-24/h6-8,11-15,18,23,34H,9-10H2,1-5H3,(H,31,32)/t18-,23+/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269881
PNG
((1S,2S)—N-(4-(2,6-dimethoxyphenyl)-5-(5-methy...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)[C@H](OCC(C)(C)O)c2ncc(C)cn2)nnc1-c1cncc(C)c1
Show InChI InChI=1S/C28H35N7O6S/c1-17-11-20(15-29-12-17)26-32-33-27(35(26)23-21(39-6)9-8-10-22(23)40-7)34-42(37,38)19(3)24(41-16-28(4,5)36)25-30-13-18(2)14-31-25/h8-15,19,24,36H,16H2,1-7H3,(H,33,34)/t19-,24+/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269881
PNG
((1S,2S)—N-(4-(2,6-dimethoxyphenyl)-5-(5-methy...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)[C@H](OCC(C)(C)O)c2ncc(C)cn2)nnc1-c1cncc(C)c1
Show InChI InChI=1S/C28H35N7O6S/c1-17-11-20(15-29-12-17)26-32-33-27(35(26)23-21(39-6)9-8-10-22(23)40-7)34-42(37,38)19(3)24(41-16-28(4,5)36)25-30-13-18(2)14-31-25/h8-15,19,24,36H,16H2,1-7H3,(H,33,34)/t19-,24+/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269883
PNG
(1S,2S)—N-(4-(2,6-dimethoxyphenyl)-5-(5-methyl...)
Show SMILES COCCO[C@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C27H33N7O6S/c1-17-12-20(16-28-13-17)26-31-32-27(34(26)23-21(38-5)8-7-9-22(23)39-6)33-41(35,36)19(3)24(40-11-10-37-4)25-29-14-18(2)15-30-25/h7-9,12-16,19,24H,10-11H2,1-6H3,(H,32,33)/t19-,24+/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269884
PNG
((1S,2R)—N-(4-(2,6-dimethoxyphenyl)-5-(6-metho...)
Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@H](OCCO)c2ncc(C)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C26H31N7O7S/c1-16-14-27-24(28-15-16)23(40-13-12-34)17(2)41(35,36)32-26-31-30-25(18-8-6-11-21(29-18)39-5)33(26)22-19(37-3)9-7-10-20(22)38-4/h6-11,14-15,17,23,34H,12-13H2,1-5H3,(H,31,32)/t17-,23-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269884
PNG
((1S,2R)—N-(4-(2,6-dimethoxyphenyl)-5-(6-metho...)
Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@H](OCCO)c2ncc(C)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C26H31N7O7S/c1-16-14-27-24(28-15-16)23(40-13-12-34)17(2)41(35,36)32-26-31-30-25(18-8-6-11-21(29-18)39-5)33(26)22-19(37-3)9-7-10-20(22)38-4/h6-11,14-15,17,23,34H,12-13H2,1-5H3,(H,31,32)/t17-,23-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269886
PNG
((2S)—N-(4-(2,6-dimethoxyphenyl)-5-(5-ethenyl-...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)nnc1-c1cncc(C=C)c1
Show InChI InChI=1S/C24H24FN7O4S/c1-5-16-10-17(12-26-11-16)23-29-30-24(32(23)22-19(35-3)7-6-8-20(22)36-4)31-37(33,34)15(2)9-21-27-13-18(25)14-28-21/h5-8,10-15H,1,9H2,2-4H3,(H,30,31)/t15-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269886
PNG
((2S)—N-(4-(2,6-dimethoxyphenyl)-5-(5-ethenyl-...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)nnc1-c1cncc(C=C)c1
Show InChI InChI=1S/C24H24FN7O4S/c1-5-16-10-17(12-26-11-16)23-29-30-24(32(23)22-19(35-3)7-6-8-20(22)36-4)31-37(33,34)15(2)9-21-27-13-18(25)14-28-21/h5-8,10-15H,1,9H2,2-4H3,(H,30,31)/t15-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269888
PNG
((2S)—N-(4-(2,6-dimethoxyphenyl)-5-(5-ethyl-3-...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)Cc2ncc(F)cn2)nnc1-c1cncc(C=C)c1
Show InChI InChI=1S/C24H24FN7O4S/c1-5-16-10-17(12-26-11-16)23-29-30-24(32(23)22-19(35-3)7-6-8-20(22)36-4)31-37(33,34)15(2)9-21-27-13-18(25)14-28-21/h5-8,10-15H,1,9H2,2-4H3,(H,30,31)/t15-/m1/s1
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n/an/an/an/a 6.70n/an/a7.5n/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269888
PNG
((2S)—N-(4-(2,6-dimethoxyphenyl)-5-(5-ethyl-3-...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)Cc2ncc(F)cn2)nnc1-c1cncc(C=C)c1
Show InChI InChI=1S/C24H24FN7O4S/c1-5-16-10-17(12-26-11-16)23-29-30-24(32(23)22-19(35-3)7-6-8-20(22)36-4)31-37(33,34)15(2)9-21-27-13-18(25)14-28-21/h5-8,10-15H,1,9H2,2-4H3,(H,30,31)/t15-/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269890
PNG
((1R,2S)—N-(4-(2,6-dimethoxyphenyl)-5-(6-metho...)
Show SMILES CN[C@@H]([C@@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C25H30N8O5S/c1-15-13-27-23(28-14-15)21(26-3)16(2)39(34,35)32-25-31-30-24(17-9-7-12-20(29-17)38-6)33(25)22-18(36-4)10-8-11-19(22)37-5/h7-14,16,21,26H,1-6H3,(H,31,32)/t16-,21+/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269890
PNG
((1R,2S)—N-(4-(2,6-dimethoxyphenyl)-5-(6-metho...)
Show SMILES CN[C@@H]([C@@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C25H30N8O5S/c1-15-13-27-23(28-14-15)21(26-3)16(2)39(34,35)32-25-31-30-24(17-9-7-12-20(29-17)38-6)33(25)22-18(36-4)10-8-11-19(22)37-5/h7-14,16,21,26H,1-6H3,(H,31,32)/t16-,21+/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269892
PNG
((1R,2S)—N-(4-(2,6-dimethoxyphenyl)-5-(6-metho...)
Show SMILES CN[C@@H]([C@@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C25H30N8O5S/c1-15-13-27-23(28-14-15)21(26-3)16(2)39(34,35)32-25-31-30-24(17-9-7-12-20(29-17)38-6)33(25)22-18(36-4)10-8-11-19(22)37-5/h7-14,16,21,26H,1-6H3,(H,31,32)/t16-,21+/m1/s1
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n/an/an/an/a 7.10n/an/a7.5n/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269892
PNG
((1R,2S)—N-(4-(2,6-dimethoxyphenyl)-5-(6-metho...)
Show SMILES CN[C@@H]([C@@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C25H30N8O5S/c1-15-13-27-23(28-14-15)21(26-3)16(2)39(34,35)32-25-31-30-24(17-9-7-12-20(29-17)38-6)33(25)22-18(36-4)10-8-11-19(22)37-5/h7-14,16,21,26H,1-6H3,(H,31,32)/t16-,21+/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269892
PNG
((1R,2S)—N-(4-(2,6-dimethoxyphenyl)-5-(6-metho...)
Show SMILES CN[C@@H]([C@@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C25H30N8O5S/c1-15-13-27-23(28-14-15)21(26-3)16(2)39(34,35)32-25-31-30-24(17-9-7-12-20(29-17)38-6)33(25)22-18(36-4)10-8-11-19(22)37-5/h7-14,16,21,26H,1-6H3,(H,31,32)/t16-,21+/m1/s1
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n/an/an/an/a 12.6n/an/a7.5n/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269892
PNG
((1R,2S)—N-(4-(2,6-dimethoxyphenyl)-5-(6-metho...)
Show SMILES CN[C@@H]([C@@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C25H30N8O5S/c1-15-13-27-23(28-14-15)21(26-3)16(2)39(34,35)32-25-31-30-24(17-9-7-12-20(29-17)38-6)33(25)22-18(36-4)10-8-11-19(22)37-5/h7-14,16,21,26H,1-6H3,(H,31,32)/t16-,21+/m1/s1
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n/an/an/an/a 0.340n/an/a7.5n/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269896
PNG
((1R,2S)—N-(4-(2,6-dimethoxyphenyl)-5-(5-methy...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C24H26ClN7O5S/c1-14-9-16(11-26-10-14)23-29-30-24(32(23)20-18(35-3)7-6-8-19(20)36-4)31-38(33,34)15(2)21(37-5)22-27-12-17(25)13-28-22/h6-13,15,21H,1-5H3,(H,30,31)/t15-,21-/m0/s1
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n/an/an/an/a 2.5n/an/a7.5n/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269897
PNG
((1R,2S)-1-(5-chloropyrimidin-2-yl)-N-(4-(2,6-dimet...)
Show SMILES CCO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C25H28ClN7O5S/c1-6-38-22(23-28-13-18(26)14-29-23)16(3)39(34,35)32-25-31-30-24(17-10-15(2)11-27-12-17)33(25)21-19(36-4)8-7-9-20(21)37-5/h7-14,16,22H,6H2,1-5H3,(H,31,32)/t16-,22-/m0/s1
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n/an/an/an/a 0.270n/an/a7.5n/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269898
PNG
((1R,2S)-1-(5-chloropyrimidin-2-yl)-N-(4-(2,6-dimet...)
Show SMILES CCO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccnc2)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C24H26ClN7O5S/c1-5-37-21(22-27-13-17(25)14-28-22)15(2)38(33,34)31-24-30-29-23(16-8-7-11-26-12-16)32(24)20-18(35-3)9-6-10-19(20)36-4/h6-15,21H,5H2,1-4H3,(H,30,31)/t15-,21-/m0/s1
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n/an/an/an/a 0.530n/an/a7.5n/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269899
PNG
((1R,2S)-1-(5-chloro-2-pyrimidinyl)-N-(4-(2,6-dimet...)
Show SMILES CCO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccnc2)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C24H26ClN7O5S/c1-5-37-21(22-27-13-17(25)14-28-22)15(2)38(33,34)31-24-30-29-23(16-8-7-11-26-12-16)32(24)20-18(35-3)9-6-10-19(20)36-4/h6-15,21H,5H2,1-4H3,(H,30,31)/t15-,21-/m0/s1
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n/an/an/an/a 0.530n/an/a7.5n/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269900
PNG
((2S,3R)—N-(4-(2,6-dimethoxyphenyl)-5-(6-metho...)
Show SMILES COc1cccc(n1)-c1nnc(N(CC[Si](C)(C)C)S(=O)(=O)[C@@H](C)[C@@H](O)C(C)(C)C)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C28H43N5O6SSi/c1-19(25(34)28(2,3)4)40(35,36)32(17-18-41(8,9)10)27-31-30-26(20-13-11-16-23(29-20)39-7)33(27)24-21(37-5)14-12-15-22(24)38-6/h11-16,19,25,34H,17-18H2,1-10H3/t19-,25+/m0/s1
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n/an/an/an/a 42n/an/a7.5n/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269901
PNG
((2S,3R)—N-(4-(2,6-dimethoxyphenyl)-5-(6-metho...)
Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@H](C)[C@@H](O)C(C)(C)C)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C23H31N5O6S/c1-14(20(29)23(2,3)4)35(30,31)27-22-26-25-21(15-10-8-13-18(24-15)34-7)28(22)19-16(32-5)11-9-12-17(19)33-6/h8-14,20,29H,1-7H3,(H,26,27)/t14-,20-/m1/s1
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n/an/an/an/a 120n/an/a7.5n/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269902
PNG
((2S,3S)—N-(4-(2,6-dimethoxyphenyl)-5-(6-metho...)
Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@H](C)[C@H](O)C(C)(C)C)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C23H31N5O6S/c1-14(20(29)23(2,3)4)35(30,31)27-22-26-25-21(15-10-8-13-18(24-15)34-7)28(22)19-16(32-5)11-9-12-17(19)33-6/h8-14,20,29H,1-7H3,(H,26,27)/t14-,20+/m1/s1
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n/an/an/an/a 24n/an/a7.5n/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269902
PNG
((2S,3S)—N-(4-(2,6-dimethoxyphenyl)-5-(6-metho...)
Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@H](C)[C@H](O)C(C)(C)C)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C23H31N5O6S/c1-14(20(29)23(2,3)4)35(30,31)27-22-26-25-21(15-10-8-13-18(24-15)34-7)28(22)19-16(32-5)11-9-12-17(19)33-6/h8-14,20,29H,1-7H3,(H,26,27)/t14-,20+/m1/s1
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n/an/an/an/a 100n/an/a7.5n/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269901
PNG
((2S,3R)—N-(4-(2,6-dimethoxyphenyl)-5-(6-metho...)
Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@H](C)[C@@H](O)C(C)(C)C)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C23H31N5O6S/c1-14(20(29)23(2,3)4)35(30,31)27-22-26-25-21(15-10-8-13-18(24-15)34-7)28(22)19-16(32-5)11-9-12-17(19)33-6/h8-14,20,29H,1-7H3,(H,26,27)/t14-,20-/m1/s1
PDB

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n/an/an/an/a 31n/an/a7.5n/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
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