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Found 3540 hits Enz. Inhib. hit(s) with Target = 'Aurora kinase A'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aurora kinase A


(Homo sapiens (human))
BDBM27079
PNG
(N-{3-[5-(morpholin-4-ylmethyl)-1H-1,3-benzodiazol-...)
Show SMILES O=C(Nc1c[nH]nc1-c1nc2ccc(CN3CCOCC3)cc2[nH]1)c1ccccc1
Show InChI InChI=1S/C22H22N6O2/c29-22(16-4-2-1-3-5-16)26-19-13-23-27-20(19)21-24-17-7-6-15(12-18(17)25-21)14-28-8-10-30-11-9-28/h1-7,12-13H,8-11,14H2,(H,23,27)(H,24,25)(H,26,29)
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n/an/a 3.5n/an/an/an/a7.022



Astex



Assay Description
Assays for Aurora kinase was performed in a DELFIA format. Aurora enzyme was incubated with test compound and cross-tide substrate in the reaction bu...


J Med Chem 52: 379-88 (2009)


Article DOI: 10.1021/jm800984v
BindingDB Entry DOI: 10.7270/Q2P55KT7
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Aurora kinase A


(Homo sapiens (human))
BDBM25685
PNG
(4-[(5-bromo-1,3-thiazol-2-yl)amino]-N-(2-methoxyet...)
Show SMILES COCCN(C)C(=O)c1ccc(Nc2ncc(Br)s2)cc1
Show InChI InChI=1S/C14H16BrN3O2S/c1-18(7-8-20-2)13(19)10-3-5-11(6-4-10)17-14-16-9-12(15)21-14/h3-6,9H,7-8H2,1-2H3,(H,16,17)
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n/an/a 980n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM13534
PNG
(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Show SMILES CN1CCN(CC1)c1cc(Nc2cc(C)n[nH]2)nc(Sc2ccc(NC(=O)C3CC3)cc2)n1
Show InChI InChI=1S/C23H28N8OS/c1-15-13-20(29-28-15)25-19-14-21(31-11-9-30(2)10-12-31)27-23(26-19)33-18-7-5-17(6-8-18)24-22(32)16-3-4-16/h5-8,13-14,16H,3-4,9-12H2,1-2H3,(H,24,32)(H2,25,26,27,28,29)
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Article
PubMed
n/an/a 1.40n/an/an/an/a7.022



Astex



Assay Description
Assays for Aurora kinase was performed in a DELFIA format. Aurora enzyme was incubated with test compound and cross-tide substrate in the reaction bu...


J Med Chem 52: 379-88 (2009)


Article DOI: 10.1021/jm800984v
BindingDB Entry DOI: 10.7270/Q2P55KT7
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Aurora kinase A


(Homo sapiens (human))
BDBM27081
PNG
(3-{3-[5-(morpholin-4-ylmethyl)-1H-1,3-benzodiazol-...)
Show SMILES O=C(Nc1c[nH]nc1-c1nc2ccc(CN3CCOCC3)cc2[nH]1)Nc1ccccc1
Show InChI InChI=1S/C22H23N7O2/c30-22(24-16-4-2-1-3-5-16)27-19-13-23-28-20(19)21-25-17-7-6-15(12-18(17)26-21)14-29-8-10-31-11-9-29/h1-7,12-13H,8-11,14H2,(H,23,28)(H,25,26)(H2,24,27,30)
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n/an/a 12n/an/an/an/a7.022



Astex



Assay Description
Assays for Aurora kinase was performed in a DELFIA format. Aurora enzyme was incubated with test compound and cross-tide substrate in the reaction bu...


J Med Chem 52: 379-88 (2009)


Article DOI: 10.1021/jm800984v
BindingDB Entry DOI: 10.7270/Q2P55KT7
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Aurora kinase A


(Homo sapiens (human))
BDBM27082
PNG
(1-(2-fluorophenyl)-3-{3-[5-(morpholin-4-ylmethyl)-...)
Show SMILES Fc1ccccc1NC(=O)Nc1c[nH]nc1-c1nc2ccc(CN3CCOCC3)cc2[nH]1
Show InChI InChI=1S/C22H22FN7O2/c23-15-3-1-2-4-16(15)27-22(31)28-19-12-24-29-20(19)21-25-17-6-5-14(11-18(17)26-21)13-30-7-9-32-10-8-30/h1-6,11-12H,7-10,13H2,(H,24,29)(H,25,26)(H2,27,28,31)
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n/an/a 2.80n/an/an/an/a7.022



Astex



Assay Description
Assays for Aurora kinase was performed in a DELFIA format. Aurora enzyme was incubated with test compound and cross-tide substrate in the reaction bu...


J Med Chem 52: 379-88 (2009)


Article DOI: 10.1021/jm800984v
BindingDB Entry DOI: 10.7270/Q2P55KT7
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Aurora kinase A


(Homo sapiens (human))
BDBM27083
PNG
(1-(2,6-difluorophenyl)-3-{3-[5-(morpholin-4-ylmeth...)
Show SMILES Fc1cccc(F)c1NC(=O)Nc1c[nH]nc1-c1nc2ccc(CN3CCOCC3)cc2[nH]1
Show InChI InChI=1S/C22H21F2N7O2/c23-14-2-1-3-15(24)19(14)29-22(32)28-18-11-25-30-20(18)21-26-16-5-4-13(10-17(16)27-21)12-31-6-8-33-9-7-31/h1-5,10-11H,6-9,12H2,(H,25,30)(H,26,27)(H2,28,29,32)
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n/an/a 1.5n/an/an/an/a7.022



Astex



Assay Description
Assays for Aurora kinase was performed in a DELFIA format. Aurora enzyme was incubated with test compound and cross-tide substrate in the reaction bu...


J Med Chem 52: 379-88 (2009)


Article DOI: 10.1021/jm800984v
BindingDB Entry DOI: 10.7270/Q2P55KT7
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Aurora kinase A


(Homo sapiens (human))
BDBM27084
PNG
(1-cyclohexyl-3-{3-[5-(morpholin-4-ylmethyl)-1H-1,3...)
Show SMILES O=C(NC1CCCCC1)Nc1c[nH]nc1-c1nc2ccc(CN3CCOCC3)cc2[nH]1
Show InChI InChI=1S/C22H29N7O2/c30-22(24-16-4-2-1-3-5-16)27-19-13-23-28-20(19)21-25-17-7-6-15(12-18(17)26-21)14-29-8-10-31-11-9-29/h6-7,12-13,16H,1-5,8-11,14H2,(H,23,28)(H,25,26)(H2,24,27,30)
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n/an/a 5.70n/an/an/an/a7.022



Astex



Assay Description
Assays for Aurora kinase was performed in a DELFIA format. Aurora enzyme was incubated with test compound and cross-tide substrate in the reaction bu...


J Med Chem 52: 379-88 (2009)


Article DOI: 10.1021/jm800984v
BindingDB Entry DOI: 10.7270/Q2P55KT7
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Aurora kinase A


(Homo sapiens (human))
BDBM27085
PNG
(3-{3-[5-(morpholin-4-ylmethyl)-1H-1,3-benzodiazol-...)
Show SMILES O=C(Nc1c[nH]nc1-c1nc2ccc(CN3CCOCC3)cc2[nH]1)Nc1cccnc1
Show InChI InChI=1S/C21H22N8O2/c30-21(24-15-2-1-5-22-11-15)27-18-12-23-28-19(18)20-25-16-4-3-14(10-17(16)26-20)13-29-6-8-31-9-7-29/h1-5,10-12H,6-9,13H2,(H,23,28)(H,25,26)(H2,24,27,30)
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n/an/a 13n/an/an/an/a7.022



Astex



Assay Description
Assays for Aurora kinase was performed in a DELFIA format. Aurora enzyme was incubated with test compound and cross-tide substrate in the reaction bu...


J Med Chem 52: 379-88 (2009)


Article DOI: 10.1021/jm800984v
BindingDB Entry DOI: 10.7270/Q2P55KT7
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Aurora kinase A


(Homo sapiens (human))
BDBM27086
PNG
(3-{3-[5-(morpholin-4-ylmethyl)-1H-1,3-benzodiazol-...)
Show SMILES O=C(NC1CCOCC1)Nc1c[nH]nc1-c1nc2ccc(CN3CCOCC3)cc2[nH]1
Show InChI InChI=1S/C21H27N7O3/c29-21(23-15-3-7-30-8-4-15)26-18-12-22-27-19(18)20-24-16-2-1-14(11-17(16)25-20)13-28-5-9-31-10-6-28/h1-2,11-12,15H,3-10,13H2,(H,22,27)(H,24,25)(H2,23,26,29)
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n/an/a 26n/an/an/an/a7.022



Astex



Assay Description
Assays for Aurora kinase was performed in a DELFIA format. Aurora enzyme was incubated with test compound and cross-tide substrate in the reaction bu...


J Med Chem 52: 379-88 (2009)


Article DOI: 10.1021/jm800984v
BindingDB Entry DOI: 10.7270/Q2P55KT7
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Aurora kinase A


(Homo sapiens (human))
BDBM27087
PNG
(3-cyclopropyl-1-{3-[5-(morpholin-4-ylmethyl)-1H-1,...)
Show SMILES O=C(NC1CC1)Nc1c[nH]nc1-c1nc2ccc(CN3CCOCC3)cc2[nH]1
Show InChI InChI=1S/C19H23N7O2/c27-19(21-13-2-3-13)24-16-10-20-25-17(16)18-22-14-4-1-12(9-15(14)23-18)11-26-5-7-28-8-6-26/h1,4,9-10,13H,2-3,5-8,11H2,(H,20,25)(H,22,23)(H2,21,24,27)
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n/an/an/an/an/an/an/a7.022



Astex



Assay Description
Assays for Aurora kinase was performed in a DELFIA format. Aurora enzyme was incubated with test compound and cross-tide substrate in the reaction bu...


J Med Chem 52: 379-88 (2009)


Article DOI: 10.1021/jm800984v
BindingDB Entry DOI: 10.7270/Q2P55KT7
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Aurora kinase A


(Homo sapiens (human))
BDBM24637
PNG
(2-(1H-pyrazol-3-yl)-1H-1,3-benzodiazole | JMC52379...)
Show SMILES c1cc(n[nH]1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C10H8N4/c1-2-4-8-7(3-1)12-10(13-8)9-5-6-11-14-9/h1-6H,(H,11,14)(H,12,13)
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n/an/a 910n/an/an/an/a7.022



Astex



Assay Description
Assays for Aurora kinase was performed in a DELFIA format. Aurora enzyme was incubated with test compound and cross-tide substrate in the reaction bu...


J Med Chem 52: 379-88 (2009)


Article DOI: 10.1021/jm800984v
BindingDB Entry DOI: 10.7270/Q2P55KT7
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Aurora kinase A


(Homo sapiens (human))
BDBM27077
PNG
(N-[3-(1H-1,3-benzodiazol-2-yl)-1H-pyrazol-4-yl]ace...)
Show SMILES CC(=O)Nc1c[nH]nc1-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C12H11N5O/c1-7(18)14-10-6-13-17-11(10)12-15-8-4-2-3-5-9(8)16-12/h2-6H,1H3,(H,13,17)(H,14,18)(H,15,16)
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n/an/a 70n/an/an/an/a7.022



Astex



Assay Description
Assays for Aurora kinase was performed in a DELFIA format. Aurora enzyme was incubated with test compound and cross-tide substrate in the reaction bu...


J Med Chem 52: 379-88 (2009)


Article DOI: 10.1021/jm800984v
BindingDB Entry DOI: 10.7270/Q2P55KT7
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Aurora kinase A


(Homo sapiens (human))
BDBM27078
PNG
(N-[3-(1H-1,3-benzodiazol-2-yl)-1H-pyrazol-4-yl]ben...)
Show SMILES O=C(Nc1c[nH]nc1-c1nc2ccccc2[nH]1)c1ccccc1
Show InChI InChI=1S/C17H13N5O/c23-17(11-6-2-1-3-7-11)21-14-10-18-22-15(14)16-19-12-8-4-5-9-13(12)20-16/h1-10H,(H,18,22)(H,19,20)(H,21,23)
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n/an/a 5.90n/an/an/an/a7.022



Astex



Assay Description
Assays for Aurora kinase was performed in a DELFIA format. Aurora enzyme was incubated with test compound and cross-tide substrate in the reaction bu...


J Med Chem 52: 379-88 (2009)


Article DOI: 10.1021/jm800984v
BindingDB Entry DOI: 10.7270/Q2P55KT7
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Aurora kinase A


(Homo sapiens (human))
BDBM25656
PNG
(N-(4-fluorophenyl)-1,3-thiazol-2-amine | aminothia...)
Show SMILES Fc1ccc(Nc2nccs2)cc1
Show InChI InChI=1S/C9H7FN2S/c10-7-1-3-8(4-2-7)12-9-11-5-6-13-9/h1-6H,(H,11,12)
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n/an/a>1.00E+4n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25657
PNG
(5-chloro-N-(4-fluorophenyl)-1,3-thiazol-2-amine | ...)
Show SMILES Fc1ccc(Nc2ncc(Cl)s2)cc1
Show InChI InChI=1S/C9H6ClFN2S/c10-8-5-12-9(14-8)13-7-3-1-6(11)2-4-7/h1-5H,(H,12,13)
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n/an/a 1.10E+3n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25658
PNG
(5-bromo-N-(4-fluorophenyl)-1,3-thiazol-2-amine | a...)
Show SMILES Fc1ccc(Nc2ncc(Br)s2)cc1
Show InChI InChI=1S/C9H6BrFN2S/c10-8-5-12-9(14-8)13-7-3-1-6(11)2-4-7/h1-5H,(H,12,13)
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n/an/a 400n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25659
PNG
(4-bromo-N-(4-fluorophenyl)-1,3-thiazol-2-amine | a...)
Show SMILES Fc1ccc(Nc2nc(Br)cs2)cc1
Show InChI InChI=1S/C9H6BrFN2S/c10-8-5-14-9(13-8)12-7-3-1-6(11)2-4-7/h1-5H,(H,12,13)
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n/an/a>1.00E+4n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25660
PNG
(N-(4-fluorophenyl)-5-iodo-1,3-thiazol-2-amine | am...)
Show SMILES Fc1ccc(Nc2ncc(I)s2)cc1
Show InChI InChI=1S/C9H6FIN2S/c10-6-1-3-7(4-2-6)13-9-12-5-8(11)14-9/h1-5H,(H,12,13)
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n/an/a 500n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25661
PNG
(5-bromo-N-(4-fluorophenyl)-N-methyl-1,3-thiazol-2-...)
Show SMILES CN(c1ncc(Br)s1)c1ccc(F)cc1
Show InChI InChI=1S/C10H8BrFN2S/c1-14(10-13-6-9(11)15-10)8-4-2-7(12)3-5-8/h2-6H,1H3
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n/an/a>1.00E+4n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25662
PNG
(5-bromo-N-phenyl-1,3-thiazol-2-amine | aminothiazo...)
Show SMILES Brc1cnc(Nc2ccccc2)s1
Show InChI InChI=1S/C9H7BrN2S/c10-8-6-11-9(13-8)12-7-4-2-1-3-5-7/h1-6H,(H,11,12)
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n/an/a 1.10E+3n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25663
PNG
(5-bromo-N-(4-chlorophenyl)-1,3-thiazol-2-amine | a...)
Show SMILES Clc1ccc(Nc2ncc(Br)s2)cc1
Show InChI InChI=1S/C9H6BrClN2S/c10-8-5-12-9(14-8)13-7-3-1-6(11)2-4-7/h1-5H,(H,12,13)
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PubMed
n/an/a 3.00E+3n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25664
PNG
(5-bromo-N-(4-bromophenyl)-1,3-thiazol-2-amine | am...)
Show SMILES Brc1cnc(Nc2ccc(Br)cc2)s1
Show InChI InChI=1S/C9H6Br2N2S/c10-6-1-3-7(4-2-6)13-9-12-5-8(11)14-9/h1-5H,(H,12,13)
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PubMed
n/an/a 2.90E+3n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25665
PNG
(5-bromo-N-(4-iodophenyl)-1,3-thiazol-2-amine | ami...)
Show SMILES Brc1cnc(Nc2ccc(I)cc2)s1
Show InChI InChI=1S/C9H6BrIN2S/c10-8-5-12-9(14-8)13-7-3-1-6(11)2-4-7/h1-5H,(H,12,13)
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n/an/a>1.00E+4n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25666
PNG
(5-bromo-N-(4-methylphenyl)-1,3-thiazol-2-amine | a...)
Show SMILES Cc1ccc(Nc2ncc(Br)s2)cc1
Show InChI InChI=1S/C10H9BrN2S/c1-7-2-4-8(5-3-7)13-10-12-6-9(11)14-10/h2-6H,1H3,(H,12,13)
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PubMed
n/an/a 2.84E+3n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25667
PNG
(5-bromo-N-[4-(trifluoromethyl)phenyl]-1,3-thiazol-...)
Show SMILES FC(F)(F)c1ccc(Nc2ncc(Br)s2)cc1
Show InChI InChI=1S/C10H6BrF3N2S/c11-8-5-15-9(17-8)16-7-3-1-6(2-4-7)10(12,13)14/h1-5H,(H,15,16)
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n/an/a 2.40E+3n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25668
PNG
(4-[(5-bromo-1,3-thiazol-2-yl)amino]benzonitrile | ...)
Show SMILES Brc1cnc(Nc2ccc(cc2)C#N)s1
Show InChI InChI=1S/C10H6BrN3S/c11-9-6-13-10(15-9)14-8-3-1-7(5-12)2-4-8/h1-4,6H,(H,13,14)
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n/an/a 2.10E+3n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25669
PNG
(4-[(5-bromo-1,3-thiazol-2-yl)amino]phenol | aminot...)
Show SMILES Oc1ccc(Nc2ncc(Br)s2)cc1
Show InChI InChI=1S/C9H7BrN2OS/c10-8-5-11-9(14-8)12-6-1-3-7(13)4-2-6/h1-5,13H,(H,11,12)
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n/an/a 510n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25670
PNG
(5-bromo-N-(4-methoxyphenyl)-1,3-thiazol-2-amine | ...)
Show SMILES COc1ccc(Nc2ncc(Br)s2)cc1
Show InChI InChI=1S/C10H9BrN2OS/c1-14-8-4-2-7(3-5-8)13-10-12-6-9(11)15-10/h2-6H,1H3,(H,12,13)
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n/an/a 1.70E+3n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25671
PNG
(5-bromo-N-[4-(trifluoromethoxy)phenyl]-1,3-thiazol...)
Show SMILES FC(F)(F)Oc1ccc(Nc2ncc(Br)s2)cc1
Show InChI InChI=1S/C10H6BrF3N2OS/c11-8-5-15-9(18-8)16-6-1-3-7(4-2-6)17-10(12,13)14/h1-5H,(H,15,16)
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PubMed
n/an/a 1.72E+4n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25672
PNG
(5-bromo-N-(4-phenoxyphenyl)-1,3-thiazol-2-amine | ...)
Show SMILES Brc1cnc(Nc2ccc(Oc3ccccc3)cc2)s1
Show InChI InChI=1S/C15H11BrN2OS/c16-14-10-17-15(20-14)18-11-6-8-13(9-7-11)19-12-4-2-1-3-5-12/h1-10H,(H,17,18)
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n/an/a 1.40E+3n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25673
PNG
(5-bromo-N-[4-(pyridin-4-yloxy)phenyl]-1,3-thiazol-...)
Show SMILES Brc1cnc(Nc2ccc(Oc3ccncc3)cc2)s1
Show InChI InChI=1S/C14H10BrN3OS/c15-13-9-17-14(20-13)18-10-1-3-11(4-2-10)19-12-5-7-16-8-6-12/h1-9H,(H,17,18)
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n/an/a 900n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25674
PNG
(1-{4-[(5-bromo-1,3-thiazol-2-yl)amino]phenyl}ethan...)
Show SMILES CC(=O)c1ccc(Nc2ncc(Br)s2)cc1
Show InChI InChI=1S/C11H9BrN2OS/c1-7(15)8-2-4-9(5-3-8)14-11-13-6-10(12)16-11/h2-6H,1H3,(H,13,14)
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n/an/a 1.70E+3n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25675
PNG
(5-bromo-N-(4-nitrophenyl)-1,3-thiazol-2-amine | am...)
Show SMILES [O-][N+](=O)c1ccc(Nc2ncc(Br)s2)cc1
Show InChI InChI=1S/C9H6BrN3O2S/c10-8-5-11-9(16-8)12-6-1-3-7(4-2-6)13(14)15/h1-5H,(H,11,12)
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PubMed
n/an/a 1.30E+4n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25676
PNG
(1-N-(5-bromo-1,3-thiazol-2-yl)benzene-1,4-diamine ...)
Show SMILES Nc1ccc(Nc2ncc(Br)s2)cc1
Show InChI InChI=1S/C9H8BrN3S/c10-8-5-12-9(14-8)13-7-3-1-6(11)2-4-7/h1-5H,11H2,(H,12,13)
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n/an/a 600n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25677
PNG
(N-{4-[(5-bromo-1,3-thiazol-2-yl)amino]phenyl}benza...)
Show SMILES Brc1cnc(Nc2ccc(NC(=O)c3ccccc3)cc2)s1
Show InChI InChI=1S/C16H12BrN3OS/c17-14-10-18-16(22-14)20-13-8-6-12(7-9-13)19-15(21)11-4-2-1-3-5-11/h1-10H,(H,18,20)(H,19,21)
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PubMed
n/an/a 9.20E+3n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25678
PNG
(N-{4-[(5-bromo-1,3-thiazol-2-yl)amino]phenyl}aceta...)
Show SMILES CC(=O)Nc1ccc(Nc2ncc(Br)s2)cc1
Show InChI InChI=1S/C11H10BrN3OS/c1-7(16)14-8-2-4-9(5-3-8)15-11-13-6-10(12)17-11/h2-6H,1H3,(H,13,15)(H,14,16)
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n/an/a 360n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25679
PNG
(aminothiazole analogue, 23 | ethyl 4-[(5-bromo-1,3...)
Show SMILES CCOC(=O)c1ccc(Nc2ncc(Br)s2)cc1
Show InChI InChI=1S/C12H11BrN2O2S/c1-2-17-11(16)8-3-5-9(6-4-8)15-12-14-7-10(13)18-12/h3-7H,2H2,1H3,(H,14,15)
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n/an/a 5.70E+3n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25680
PNG
(4-[(5-bromo-1,3-thiazol-2-yl)amino]benzoic acid | ...)
Show SMILES OC(=O)c1ccc(Nc2ncc(Br)s2)cc1
Show InChI InChI=1S/C10H7BrN2O2S/c11-8-5-12-10(16-8)13-7-3-1-6(2-4-7)9(14)15/h1-5H,(H,12,13)(H,14,15)
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n/an/a 79n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25681
PNG
(4-[(5-bromo-1,3-thiazol-2-yl)amino]-N-methylbenzam...)
Show SMILES CNC(=O)c1ccc(Nc2ncc(Br)s2)cc1
Show InChI InChI=1S/C11H10BrN3OS/c1-13-10(16)7-2-4-8(5-3-7)15-11-14-6-9(12)17-11/h2-6H,1H3,(H,13,16)(H,14,15)
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PubMed
n/an/a 140n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25682
PNG
(4-[(5-bromo-1,3-thiazol-2-yl)amino]-N-(2-hydroxyet...)
Show SMILES OCCNC(=O)c1ccc(Nc2ncc(Br)s2)cc1
Show InChI InChI=1S/C12H12BrN3O2S/c13-10-7-15-12(19-10)16-9-3-1-8(2-4-9)11(18)14-5-6-17/h1-4,7,17H,5-6H2,(H,14,18)(H,15,16)
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PubMed
n/an/a 1.48E+3n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25683
PNG
(4-[(5-bromo-1,3-thiazol-2-yl)amino]-N-(2-methoxyet...)
Show SMILES COCCNC(=O)c1ccc(Nc2ncc(Br)s2)cc1
Show InChI InChI=1S/C13H14BrN3O2S/c1-19-7-6-15-12(18)9-2-4-10(5-3-9)17-13-16-8-11(14)20-13/h2-5,8H,6-7H2,1H3,(H,15,18)(H,16,17)
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n/an/a 97n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25684
PNG
(4-[(5-bromo-1,3-thiazol-2-yl)amino]-N-(1-methoxypr...)
Show SMILES COCC(C)NC(=O)c1ccc(Nc2ncc(Br)s2)cc1
Show InChI InChI=1S/C14H16BrN3O2S/c1-9(8-20-2)17-13(19)10-3-5-11(6-4-10)18-14-16-7-12(15)21-14/h3-7,9H,8H2,1-2H3,(H,16,18)(H,17,19)
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n/an/a 330n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM27080
PNG
(4-fluoro-N-{3-[5-(morpholin-4-ylmethyl)-1H-1,3-ben...)
Show SMILES Fc1ccc(cc1)C(=O)Nc1c[nH]nc1-c1nc2ccc(CN3CCOCC3)cc2[nH]1
Show InChI InChI=1S/C22H21FN6O2/c23-16-4-2-15(3-5-16)22(30)27-19-12-24-28-20(19)21-25-17-6-1-14(11-18(17)26-21)13-29-7-9-31-10-8-29/h1-6,11-12H,7-10,13H2,(H,24,28)(H,25,26)(H,27,30)
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n/an/a 10n/an/an/an/a7.022



Astex



Assay Description
Assays for Aurora kinase was performed in a DELFIA format. Aurora enzyme was incubated with test compound and cross-tide substrate in the reaction bu...


J Med Chem 52: 379-88 (2009)


Article DOI: 10.1021/jm800984v
BindingDB Entry DOI: 10.7270/Q2P55KT7
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Aurora Kinase A (Aurora-A)


(Mus musculus (mouse))
BDBM26323
PNG
(1-(3-methoxyphenyl)-3-[5-(2-{thieno[3,2-d]pyrimidi...)
Show SMILES COc1cccc(NC(=O)Nc2ncc(CCNc3ncnc4ccsc34)s2)c1
Show InChI InChI=1S/C19H18N6O2S2/c1-27-13-4-2-3-12(9-13)24-18(26)25-19-21-10-14(29-19)5-7-20-17-16-15(6-8-28-16)22-11-23-17/h2-4,6,8-11H,5,7H2,1H3,(H,20,22,23)(H2,21,24,25,26)
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n/an/a 50n/an/an/an/a7.221



Sunesis Pharmaceuticals



Assay Description
Compounds were diluted into assay buffer containing Aurora kinase and FAM-PKAtide. The kinase reaction was initiated by adding ATP in assay buffer. T...


Bioorg Med Chem Lett 18: 4880-4 (2008)


Article DOI: 10.1016/j.bmcl.2008.07.073
BindingDB Entry DOI: 10.7270/Q279430N
More data for this
Ligand-Target Pair
Aurora Kinase A (Aurora-A)


(Mus musculus (mouse))
BDBM26322
PNG
(1-(3-methylphenyl)-3-[5-(2-{thieno[3,2-d]pyrimidin...)
Show SMILES Cc1cccc(NC(=O)Nc2ncc(CCNc3ncnc4ccsc34)s2)c1
Show InChI InChI=1S/C19H18N6OS2/c1-12-3-2-4-13(9-12)24-18(26)25-19-21-10-14(28-19)5-7-20-17-16-15(6-8-27-16)22-11-23-17/h2-4,6,8-11H,5,7H2,1H3,(H,20,22,23)(H2,21,24,25,26)
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n/an/a 9n/an/an/an/a7.221



Sunesis Pharmaceuticals



Assay Description
Compounds were diluted into assay buffer containing Aurora kinase and FAM-PKAtide. The kinase reaction was initiated by adding ATP in assay buffer. T...


Bioorg Med Chem Lett 18: 4880-4 (2008)


Article DOI: 10.1016/j.bmcl.2008.07.073
BindingDB Entry DOI: 10.7270/Q279430N
More data for this
Ligand-Target Pair
Aurora Kinase A (Aurora-A)


(Mus musculus (mouse))
BDBM26325
PNG
(1-(3-fluorophenyl)-3-[5-(2-{thieno[3,2-d]pyrimidin...)
Show SMILES Fc1cccc(NC(=O)Nc2ncc(CCNc3ncnc4ccsc34)s2)c1
Show InChI InChI=1S/C18H15FN6OS2/c19-11-2-1-3-12(8-11)24-17(26)25-18-21-9-13(28-18)4-6-20-16-15-14(5-7-27-15)22-10-23-16/h1-3,5,7-10H,4,6H2,(H,20,22,23)(H2,21,24,25,26)
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n/an/a 23n/an/an/an/a7.221



Sunesis Pharmaceuticals



Assay Description
Compounds were diluted into assay buffer containing Aurora kinase and FAM-PKAtide. The kinase reaction was initiated by adding ATP in assay buffer. T...


Bioorg Med Chem Lett 18: 4880-4 (2008)


Article DOI: 10.1016/j.bmcl.2008.07.073
BindingDB Entry DOI: 10.7270/Q279430N
More data for this
Ligand-Target Pair
Aurora Kinase A (Aurora-A)


(Mus musculus (mouse))
BDBM26326
PNG
(1-(3-chlorophenyl)-3-[5-(2-{thieno[3,2-d]pyrimidin...)
Show SMILES Clc1cccc(NC(=O)Nc2ncc(CCNc3ncnc4ccsc34)s2)c1
Show InChI InChI=1S/C18H15ClN6OS2/c19-11-2-1-3-12(8-11)24-17(26)25-18-21-9-13(28-18)4-6-20-16-15-14(5-7-27-15)22-10-23-16/h1-3,5,7-10H,4,6H2,(H,20,22,23)(H2,21,24,25,26)
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n/an/a 9n/an/an/an/a7.221



Sunesis Pharmaceuticals



Assay Description
Compounds were diluted into assay buffer containing Aurora kinase and FAM-PKAtide. The kinase reaction was initiated by adding ATP in assay buffer. T...


Bioorg Med Chem Lett 18: 4880-4 (2008)


Article DOI: 10.1016/j.bmcl.2008.07.073
BindingDB Entry DOI: 10.7270/Q279430N
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Aurora Kinase A (Aurora-A)


(Mus musculus (mouse))
BDBM26327
PNG
(1-(4-chlorophenyl)-3-[5-(2-{thieno[3,2-d]pyrimidin...)
Show SMILES Clc1ccc(NC(=O)Nc2ncc(CCNc3ncnc4ccsc34)s2)cc1
Show InChI InChI=1S/C18H15ClN6OS2/c19-11-1-3-12(4-2-11)24-17(26)25-18-21-9-13(28-18)5-7-20-16-15-14(6-8-27-15)22-10-23-16/h1-4,6,8-10H,5,7H2,(H,20,22,23)(H2,21,24,25,26)
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n/an/a 39n/an/an/an/a7.221



Sunesis Pharmaceuticals



Assay Description
Compounds were diluted into assay buffer containing Aurora kinase and FAM-PKAtide. The kinase reaction was initiated by adding ATP in assay buffer. T...


Bioorg Med Chem Lett 18: 4880-4 (2008)


Article DOI: 10.1016/j.bmcl.2008.07.073
BindingDB Entry DOI: 10.7270/Q279430N
More data for this
Ligand-Target Pair
Aurora Kinase A (Aurora-A)


(Mus musculus (mouse))
BDBM26328
PNG
(1-(2-chlorophenyl)-3-[5-(2-{thieno[3,2-d]pyrimidin...)
Show SMILES Clc1ccccc1NC(=O)Nc1ncc(CCNc2ncnc3ccsc23)s1
Show InChI InChI=1S/C18H15ClN6OS2/c19-12-3-1-2-4-13(12)24-17(26)25-18-21-9-11(28-18)5-7-20-16-15-14(6-8-27-15)22-10-23-16/h1-4,6,8-10H,5,7H2,(H,20,22,23)(H2,21,24,25,26)
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n/an/a 280n/an/an/an/a7.221



Sunesis Pharmaceuticals



Assay Description
Compounds were diluted into assay buffer containing Aurora kinase and FAM-PKAtide. The kinase reaction was initiated by adding ATP in assay buffer. T...


Bioorg Med Chem Lett 18: 4880-4 (2008)


Article DOI: 10.1016/j.bmcl.2008.07.073
BindingDB Entry DOI: 10.7270/Q279430N
More data for this
Ligand-Target Pair
Aurora Kinase A (Aurora-A)


(Mus musculus (mouse))
BDBM26329
PNG
(1-(3,4-dichlorophenyl)-3-[5-(2-{thieno[3,2-d]pyrim...)
Show SMILES Clc1ccc(NC(=O)Nc2ncc(CCNc3ncnc4ccsc34)s2)cc1Cl
Show InChI InChI=1S/C18H14Cl2N6OS2/c19-12-2-1-10(7-13(12)20)25-17(27)26-18-22-8-11(29-18)3-5-21-16-15-14(4-6-28-15)23-9-24-16/h1-2,4,6-9H,3,5H2,(H,21,23,24)(H2,22,25,26,27)
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n/an/a 96n/an/an/an/a7.221



Sunesis Pharmaceuticals



Assay Description
Compounds were diluted into assay buffer containing Aurora kinase and FAM-PKAtide. The kinase reaction was initiated by adding ATP in assay buffer. T...


Bioorg Med Chem Lett 18: 4880-4 (2008)


Article DOI: 10.1016/j.bmcl.2008.07.073
BindingDB Entry DOI: 10.7270/Q279430N
More data for this
Ligand-Target Pair
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