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Found 7952 hits Enz. Inhib. hit(s) with Target = 'Axin-1/Glycogen synthase kinase-3 beta'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Axin-1/Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM251571
PNG
(US9452998, Table 4 Compound 1)
Show SMILES NC1CCCN(C1)c1ccncc1NC(=O)c1nc(cnc1N)-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C22H22F3N7O/c23-22(24,25)15-6-2-1-5-14(15)16-11-29-20(27)19(30-16)21(33)31-17-10-28-8-7-18(17)32-9-3-4-13(26)12-32/h1-2,5-8,10-11,13H,3-4,9,12,26H2,(H2,27,29)(H,31,33)
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n/an/a 97n/an/an/an/a7.025



Novartis AG

US Patent


Assay Description
Types of GSK-3 assay used to test the selectivity/off target potential compounds of the invention with respect to PKC α/θ inhibition activity inclu...


US Patent US9452998 (2016)


BindingDB Entry DOI: 10.7270/Q2C82870
More data for this
Ligand-Target Pair
Axin-1/Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM8557
PNG
(2-({[3-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]methy...)
Show SMILES Cc1nc(no1)-c1cccc(CSc2nnc(o2)-c2ccncc2)c1
Show InChI InChI=1S/C17H13N5O2S/c1-11-19-15(22-24-11)14-4-2-3-12(9-14)10-25-17-21-20-16(23-17)13-5-7-18-8-6-13/h2-9H,10H2,1H3
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n/an/a>2.50E+5n/an/an/an/a7.022



Novo Nordisk A/S



Assay Description
In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam...


Bioorg Med Chem Lett 12: 1525-8 (2002)


Article DOI: 10.1016/s0960-894x(02)00169-5
BindingDB Entry DOI: 10.7270/Q2251GDH
More data for this
Ligand-Target Pair
Axin-1/Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM251573
PNG
(US9452998, Table 4 Compound 3)
Show SMILES NC1CCN(CC1)c1ccccc1NC(=O)c1nc(cnc1N)-c1ccccc1
Show InChI InChI=1S/C22H24N6O/c23-16-10-12-28(13-11-16)19-9-5-4-8-17(19)27-22(29)20-21(24)25-14-18(26-20)15-6-2-1-3-7-15/h1-9,14,16H,10-13,23H2,(H2,24,25)(H,27,29)
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n/an/a 1n/an/an/an/a7.025



Novartis AG

US Patent


Assay Description
Types of GSK-3 assay used to test the selectivity/off target potential compounds of the invention with respect to PKC α/θ inhibition activity inclu...


US Patent US9452998 (2016)


BindingDB Entry DOI: 10.7270/Q2C82870
More data for this
Ligand-Target Pair
Axin-1/Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM251574
PNG
(US9452998, Table 4 Compound 4)
Show SMILES NC1CCN(CC1)c1ccncc1NC(=O)c1nc(cnc1N)-c1ccccc1
Show InChI InChI=1S/C21H23N7O/c22-15-7-10-28(11-8-15)18-6-9-24-12-17(18)27-21(29)19-20(23)25-13-16(26-19)14-4-2-1-3-5-14/h1-6,9,12-13,15H,7-8,10-11,22H2,(H2,23,25)(H,27,29)
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n/an/a 0.200n/an/an/an/a7.025



Novartis AG

US Patent


Assay Description
Types of GSK-3 assay used to test the selectivity/off target potential compounds of the invention with respect to PKC α/θ inhibition activity inclu...


US Patent US9452998 (2016)


BindingDB Entry DOI: 10.7270/Q2C82870
More data for this
Ligand-Target Pair
Axin-1/Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM251575
PNG
(US9452998, Table 4 Compound 5)
Show SMILES COc1ccc(cc1)-c1cnc(N)c(n1)C(=O)Nc1cnccc1N1CCC(N)CC1
Show InChI InChI=1S/C22H25N7O2/c1-31-16-4-2-14(3-5-16)17-13-26-21(24)20(27-17)22(30)28-18-12-25-9-6-19(18)29-10-7-15(23)8-11-29/h2-6,9,12-13,15H,7-8,10-11,23H2,1H3,(H2,24,26)(H,28,30)
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n/an/a 0.200n/an/an/an/a7.025



Novartis AG

US Patent


Assay Description
Types of GSK-3 assay used to test the selectivity/off target potential compounds of the invention with respect to PKC α/θ inhibition activity inclu...


US Patent US9452998 (2016)


BindingDB Entry DOI: 10.7270/Q2C82870
More data for this
Ligand-Target Pair
Axin-1/Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM251576
PNG
(US9452998, Table 4 Compound 6)
Show SMILES Nc1ncc(nc1C(=O)Nc1cnccc1N1CCNCC1)-c1ccccc1F
Show InChI InChI=1S/C20H20FN7O/c21-14-4-2-1-3-13(14)15-12-25-19(22)18(26-15)20(29)27-16-11-24-6-5-17(16)28-9-7-23-8-10-28/h1-6,11-12,23H,7-10H2,(H2,22,25)(H,27,29)
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n/an/a 0.200n/an/an/an/a7.025



Novartis AG

US Patent


Assay Description
Types of GSK-3 assay used to test the selectivity/off target potential compounds of the invention with respect to PKC α/θ inhibition activity inclu...


US Patent US9452998 (2016)


BindingDB Entry DOI: 10.7270/Q2C82870
More data for this
Ligand-Target Pair
Axin-1/Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM251452
PNG
(US9452998, 1)
Show SMILES NC1CCN(CC1)c1cccnc1NC(=O)c1nc(cnc1N)-c1ncccc1C(F)(F)F
Show InChI InChI=1S/C21H21F3N8O/c22-21(23,24)13-3-1-7-27-16(13)14-11-29-18(26)17(30-14)20(33)31-19-15(4-2-8-28-19)32-9-5-12(25)6-10-32/h1-4,7-8,11-12H,5-6,9-10,25H2,(H2,26,29)(H,28,31,33)
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n/an/a 5.50E+3n/an/an/an/a7.025



Novartis AG

US Patent


Assay Description
Types of GSK-3 assay used to test the selectivity/off target potential compounds of the invention with respect to PKC α/θ inhibition activity inclu...


US Patent US9452998 (2016)


BindingDB Entry DOI: 10.7270/Q2C82870
More data for this
Ligand-Target Pair
Axin-1/Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM251453
PNG
(US9452998, 2)
Show SMILES NC1CCN(CC1)c1cccnc1NC(=O)c1nc(cnc1N)-c1ncccc1OC(F)(F)F
Show InChI InChI=1S/C21H21F3N8O2/c22-21(23,24)34-15-4-2-7-27-16(15)13-11-29-18(26)17(30-13)20(33)31-19-14(3-1-8-28-19)32-9-5-12(25)6-10-32/h1-4,7-8,11-12H,5-6,9-10,25H2,(H2,26,29)(H,28,31,33)
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n/an/a 2.40E+3n/an/an/an/a7.025



Novartis AG

US Patent


Assay Description
Types of GSK-3 assay used to test the selectivity/off target potential compounds of the invention with respect to PKC α/θ inhibition activity inclu...


US Patent US9452998 (2016)


BindingDB Entry DOI: 10.7270/Q2C82870
More data for this
Ligand-Target Pair
Axin-1/Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM251455
PNG
(US9452998, 4)
Show SMILES CC1(N)CCN(CC1)c1cccnc1NC(=O)c1nc(cnc1N)-c1nc(cc2ccccc12)N1CCOCC1
Show InChI InChI=1S/C29H33N9O2/c1-29(31)8-11-37(12-9-29)22-7-4-10-32-27(22)36-28(39)25-26(30)33-18-21(34-25)24-20-6-3-2-5-19(20)17-23(35-24)38-13-15-40-16-14-38/h2-7,10,17-18H,8-9,11-16,31H2,1H3,(H2,30,33)(H,32,36,39)
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n/an/a 3.10E+3n/an/an/an/a7.025



Novartis AG

US Patent


Assay Description
Types of GSK-3 assay used to test the selectivity/off target potential compounds of the invention with respect to PKC α/θ inhibition activity inclu...


US Patent US9452998 (2016)


BindingDB Entry DOI: 10.7270/Q2C82870
More data for this
Ligand-Target Pair
Axin-1/Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM251457
PNG
(US9452998, 6)
Show SMILES Nc1ncc(nc1C(=O)Nc1ncccc1N1CCC(N)(CO)CC1)-c1ncccc1OC(F)(F)F
Show InChI InChI=1S/C22H23F3N8O3/c23-22(24,25)36-15-4-2-7-28-16(15)13-11-30-18(26)17(31-13)20(35)32-19-14(3-1-8-29-19)33-9-5-21(27,12-34)6-10-33/h1-4,7-8,11,34H,5-6,9-10,12,27H2,(H2,26,30)(H,29,32,35)
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n/an/a 1.30E+3n/an/an/an/a7.025



Novartis AG

US Patent


Assay Description
Types of GSK-3 assay used to test the selectivity/off target potential compounds of the invention with respect to PKC α/θ inhibition activity inclu...


US Patent US9452998 (2016)


BindingDB Entry DOI: 10.7270/Q2C82870
More data for this
Ligand-Target Pair
Axin-1/Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM251459
PNG
(US9452998, 8)
Show SMILES NC1CCN(CC1)c1cccnc1NC(=O)c1nc(cnc1N)-c1csc(n1)N1CCOCC1
Show InChI InChI=1S/C22H27N9O2S/c23-14-3-6-30(7-4-14)17-2-1-5-25-20(17)29-21(32)18-19(24)26-12-15(27-18)16-13-34-22(28-16)31-8-10-33-11-9-31/h1-2,5,12-14H,3-4,6-11,23H2,(H2,24,26)(H,25,29,32)
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n/an/a 210n/an/an/an/a7.025



Novartis AG

US Patent


Assay Description
Types of GSK-3 assay used to test the selectivity/off target potential compounds of the invention with respect to PKC α/θ inhibition activity inclu...


US Patent US9452998 (2016)


BindingDB Entry DOI: 10.7270/Q2C82870
More data for this
Ligand-Target Pair
Axin-1/Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM251460
PNG
(US9452998, 9)
Show SMILES CC1(N)CCN(CC1)c1cccnc1NC(=O)c1nc(cnc1N)-c1ncccc1C(F)(F)F
Show InChI InChI=1S/C22H23F3N8O/c1-21(27)6-10-33(11-7-21)15-5-3-9-29-19(15)32-20(34)17-18(26)30-12-14(31-17)16-13(22(23,24)25)4-2-8-28-16/h2-5,8-9,12H,6-7,10-11,27H2,1H3,(H2,26,30)(H,29,32,34)
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n/an/a 3.10E+3n/an/an/an/a7.025



Novartis AG

US Patent


Assay Description
Types of GSK-3 assay used to test the selectivity/off target potential compounds of the invention with respect to PKC α/θ inhibition activity inclu...


US Patent US9452998 (2016)


BindingDB Entry DOI: 10.7270/Q2C82870
More data for this
Ligand-Target Pair
Axin-1/Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM251461
PNG
(US9452998, 10)
Show SMILES CC1(N)CCN(CC1)c1cccnc1NC(=O)c1nc(cnc1N)-c1ncccc1OC(F)(F)F
Show InChI InChI=1S/C22H23F3N8O2/c1-21(27)6-10-33(11-7-21)14-4-2-9-29-19(14)32-20(34)17-18(26)30-12-13(31-17)16-15(5-3-8-28-16)35-22(23,24)25/h2-5,8-9,12H,6-7,10-11,27H2,1H3,(H2,26,30)(H,29,32,34)
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n/an/a 2.10E+3n/an/an/an/a7.025



Novartis AG

US Patent


Assay Description
Types of GSK-3 assay used to test the selectivity/off target potential compounds of the invention with respect to PKC α/θ inhibition activity inclu...


US Patent US9452998 (2016)


BindingDB Entry DOI: 10.7270/Q2C82870
More data for this
Ligand-Target Pair
Axin-1/Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM251464
PNG
(US9452998, 13)
Show SMILES COc1ccnc(-c2cnc(N)c(n2)C(=O)Nc2ncccc2N2CCC(C)(N)CC2)c1C(F)(F)F
Show InChI InChI=1S/C23H25F3N8O2/c1-22(28)6-10-34(11-7-22)14-4-3-8-30-20(14)33-21(35)18-19(27)31-12-13(32-18)17-16(23(24,25)26)15(36-2)5-9-29-17/h3-5,8-9,12H,6-7,10-11,28H2,1-2H3,(H2,27,31)(H,30,33,35)
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n/an/a 2.10E+3n/an/an/an/a7.025



Novartis AG

US Patent


Assay Description
Types of GSK-3 assay used to test the selectivity/off target potential compounds of the invention with respect to PKC α/θ inhibition activity inclu...


US Patent US9452998 (2016)


BindingDB Entry DOI: 10.7270/Q2C82870
More data for this
Ligand-Target Pair
Axin-1/Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM251471
PNG
(US9452998, 20 | US9452998, 34)
Show SMILES N[C@H]1[C@H]2CC[C@@H]1CN(C2)c1cccnc1NC(=O)c1nc(cnc1N)-c1nc(ccc1C(F)(F)F)N1CCOCC1
Show InChI InChI=1S/C27H30F3N9O2/c28-27(29,30)17-5-6-20(38-8-10-41-11-9-38)36-22(17)18-12-34-24(32)23(35-18)26(40)37-25-19(2-1-7-33-25)39-13-15-3-4-16(14-39)21(15)31/h1-2,5-7,12,15-16,21H,3-4,8-11,13-14,31H2,(H2,32,34)(H,33,37,40)/t15-,16+,21-
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n/an/a 1.00E+4n/an/an/an/a7.025



Novartis AG

US Patent


Assay Description
Types of GSK-3 assay used to test the selectivity/off target potential compounds of the invention with respect to PKC α/θ inhibition activity inclu...


US Patent US9452998 (2016)


BindingDB Entry DOI: 10.7270/Q2C82870
More data for this
Ligand-Target Pair
Axin-1/Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM251472
PNG
(US9452998, 21)
Show SMILES COc1ccnc(c1F)-c1cnc(N)c(n1)C(=O)Nc1ncccc1N1CCC(C)(N)CC1
Show InChI InChI=1S/C22H25FN8O2/c1-22(25)6-10-31(11-7-22)14-4-3-8-27-20(14)30-21(32)18-19(24)28-12-13(29-18)17-16(23)15(33-2)5-9-26-17/h3-5,8-9,12H,6-7,10-11,25H2,1-2H3,(H2,24,28)(H,27,30,32)
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n/an/a 2.10E+3n/an/an/an/a7.025



Novartis AG

US Patent


Assay Description
Types of GSK-3 assay used to test the selectivity/off target potential compounds of the invention with respect to PKC α/θ inhibition activity inclu...


US Patent US9452998 (2016)


BindingDB Entry DOI: 10.7270/Q2C82870
More data for this
Ligand-Target Pair
Axin-1/Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM251481
PNG
(US9452998, 30)
Show SMILES NC1CCN(CC1)c1cccnc1NC(=O)c1nc(cnc1N)-c1ncnc2CCCCc12
Show InChI InChI=1S/C23H27N9O/c24-14-7-10-32(11-8-14)18-6-3-9-26-22(18)31-23(33)20-21(25)27-12-17(30-20)19-15-4-1-2-5-16(15)28-13-29-19/h3,6,9,12-14H,1-2,4-5,7-8,10-11,24H2,(H2,25,27)(H,26,31,33)
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n/an/a 1.50E+3n/an/an/an/a7.025



Novartis AG

US Patent


Assay Description
Types of GSK-3 assay used to test the selectivity/off target potential compounds of the invention with respect to PKC α/θ inhibition activity inclu...


US Patent US9452998 (2016)


BindingDB Entry DOI: 10.7270/Q2C82870
More data for this
Ligand-Target Pair
Axin-1/Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM251477
PNG
(US9452998, 26 | US9452998, 75)
Show SMILES COc1ccnc(-c2cnc(N)c(n2)C(=O)Nc2ncccc2N2CCC(C)(N)CC2)c1C#N
Show InChI InChI=1S/C23H25N9O2/c1-23(26)6-10-32(11-7-23)16-4-3-8-28-21(16)31-22(33)19-20(25)29-13-15(30-19)18-14(12-24)17(34-2)5-9-27-18/h3-5,8-9,13H,6-7,10-11,26H2,1-2H3,(H2,25,29)(H,28,31,33)
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n/an/a 2.40E+3n/an/an/an/a7.025



Novartis AG

US Patent


Assay Description
Types of GSK-3 assay used to test the selectivity/off target potential compounds of the invention with respect to PKC α/θ inhibition activity inclu...


US Patent US9452998 (2016)


BindingDB Entry DOI: 10.7270/Q2C82870
More data for this
Ligand-Target Pair
Axin-1/Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM251507
PNG
(US9452998, 56 | US9452998, 76)
Show SMILES NC1CCN(CC1)c1cccnc1NC(=O)c1nc(cnc1N)-c1cc(ccc1C(F)(F)F)N1CCOCC1
Show InChI InChI=1S/C26H29F3N8O2/c27-26(28,29)19-4-3-17(36-10-12-39-13-11-36)14-18(19)20-15-33-23(31)22(34-20)25(38)35-24-21(2-1-7-32-24)37-8-5-16(30)6-9-37/h1-4,7,14-16H,5-6,8-13,30H2,(H2,31,33)(H,32,35,38)
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US Patent
n/an/a 6.50E+3n/an/an/an/a7.025



Novartis AG

US Patent


Assay Description
Types of GSK-3 assay used to test the selectivity/off target potential compounds of the invention with respect to PKC α/θ inhibition activity inclu...


US Patent US9452998 (2016)


BindingDB Entry DOI: 10.7270/Q2C82870
More data for this
Ligand-Target Pair
Axin-1/Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM251517
PNG
(US9452998, 66 | US9452998, 77)
Show SMILES NC1CCN(CC1)c1cccnc1NC(=O)c1nc(cnc1N)-c1nc(ccc1C(F)(F)F)N1CCOCC1
Show InChI InChI=1S/C25H28F3N9O2/c26-25(27,28)16-3-4-19(37-10-12-39-13-11-37)34-20(16)17-14-32-22(30)21(33-17)24(38)35-23-18(2-1-7-31-23)36-8-5-15(29)6-9-36/h1-4,7,14-15H,5-6,8-13,29H2,(H2,30,32)(H,31,35,38)
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US Patent
n/an/a>1.00E+4n/an/an/an/a7.025



Novartis AG

US Patent


Assay Description
Types of GSK-3 assay used to test the selectivity/off target potential compounds of the invention with respect to PKC α/θ inhibition activity inclu...


US Patent US9452998 (2016)


BindingDB Entry DOI: 10.7270/Q2C82870
More data for this
Ligand-Target Pair
Axin-1/Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM251523
PNG
(US9452998, 72 | US9452998, 78)
Show SMILES NC1CCN(CC1)c1cccnc1NC(=O)c1nc(cnc1N)-c1nc(cc2ccccc12)N1CCOCC1
Show InChI InChI=1S/C28H31N9O2/c29-19-7-10-36(11-8-19)22-6-3-9-31-27(22)35-28(38)25-26(30)32-17-21(33-25)24-20-5-2-1-4-18(20)16-23(34-24)37-12-14-39-15-13-37/h1-6,9,16-17,19H,7-8,10-15,29H2,(H2,30,32)(H,31,35,38)
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n/an/a 3.40E+3n/an/an/an/a7.025



Novartis AG

US Patent


Assay Description
Types of GSK-3 assay used to test the selectivity/off target potential compounds of the invention with respect to PKC α/θ inhibition activity inclu...


US Patent US9452998 (2016)


BindingDB Entry DOI: 10.7270/Q2C82870
More data for this
Ligand-Target Pair
Axin-1/Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM8541
PNG
(N-[2-(2-fluorophenyl)ethyl]-2-[4-({[5-(pyridin-4-y...)
Show SMILES Fc1ccccc1CCNC(=O)Cc1ccc(CSc2nnc(o2)-c2ccncc2)cc1
Show InChI InChI=1S/C24H21FN4O2S/c25-21-4-2-1-3-19(21)11-14-27-22(30)15-17-5-7-18(8-6-17)16-32-24-29-28-23(31-24)20-9-12-26-13-10-20/h1-10,12-13H,11,14-16H2,(H,27,30)
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n/an/a 1.20E+3n/an/an/an/a7.022



Novo Nordisk A/S



Assay Description
In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam...


Bioorg Med Chem Lett 12: 1525-8 (2002)


Article DOI: 10.1016/s0960-894x(02)00169-5
BindingDB Entry DOI: 10.7270/Q2251GDH
More data for this
Ligand-Target Pair
Axin-1/Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM8542
PNG
(2-[4-({[5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl]sul...)
Show SMILES OC(=O)Cc1ccc(CSc2nnc(s2)-c2ccncc2)cc1
Show InChI InChI=1S/C16H13N3O2S2/c20-14(21)9-11-1-3-12(4-2-11)10-22-16-19-18-15(23-16)13-5-7-17-8-6-13/h1-8H,9-10H2,(H,20,21)
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n/an/a 1.10E+4n/an/an/an/a7.022



Novo Nordisk A/S



Assay Description
In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam...


Bioorg Med Chem Lett 12: 1525-8 (2002)


Article DOI: 10.1016/s0960-894x(02)00169-5
BindingDB Entry DOI: 10.7270/Q2251GDH
More data for this
Ligand-Target Pair
Axin-1/Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM8543
PNG
(2-[4-({[5-(pyridin-4-yl)-1,3,4-oxadiazol-2-yl]sulf...)
Show SMILES OC(=O)Cc1ccc(CSc2nnc(o2)-c2ccncc2)cc1
Show InChI InChI=1S/C16H13N3O3S/c20-14(21)9-11-1-3-12(4-2-11)10-23-16-19-18-15(22-16)13-5-7-17-8-6-13/h1-8H,9-10H2,(H,20,21)
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n/an/a 8.00E+3n/an/an/an/a7.022



Novo Nordisk A/S



Assay Description
In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam...


Bioorg Med Chem Lett 12: 1525-8 (2002)


Article DOI: 10.1016/s0960-894x(02)00169-5
BindingDB Entry DOI: 10.7270/Q2251GDH
More data for this
Ligand-Target Pair
Axin-1/Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM8544
PNG
(2-[4-({[5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl]sul...)
Show SMILES OC(=O)Cc1ccc(CSc2nnc([nH]2)-c2ccncc2)cc1
Show InChI InChI=1S/C16H14N4O2S/c21-14(22)9-11-1-3-12(4-2-11)10-23-16-18-15(19-20-16)13-5-7-17-8-6-13/h1-8H,9-10H2,(H,21,22)(H,18,19,20)
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n/an/a>2.50E+5n/an/an/an/a7.022



Novo Nordisk A/S



Assay Description
In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam...


Bioorg Med Chem Lett 12: 1525-8 (2002)


Article DOI: 10.1016/s0960-894x(02)00169-5
BindingDB Entry DOI: 10.7270/Q2251GDH
More data for this
Ligand-Target Pair
Axin-1/Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM8545
PNG
(2-[4-({[5-(pyridin-3-yl)-1,3,4-thiadiazol-2-yl]sul...)
Show SMILES OC(=O)Cc1ccc(CSc2nnc(s2)-c2cccnc2)cc1
Show InChI InChI=1S/C16H13N3O2S2/c20-14(21)8-11-3-5-12(6-4-11)10-22-16-19-18-15(23-16)13-2-1-7-17-9-13/h1-7,9H,8,10H2,(H,20,21)
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n/an/a>2.50E+5n/an/an/an/a7.022



Novo Nordisk A/S



Assay Description
In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam...


Bioorg Med Chem Lett 12: 1525-8 (2002)


Article DOI: 10.1016/s0960-894x(02)00169-5
BindingDB Entry DOI: 10.7270/Q2251GDH
More data for this
Ligand-Target Pair
Axin-1/Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM8546
PNG
(2-[4-({[5-(pyridin-2-yl)-1,3,4-thiadiazol-2-yl]sul...)
Show SMILES OC(=O)Cc1ccc(CSc2nnc(s2)-c2ccccn2)cc1
Show InChI InChI=1S/C16H13N3O2S2/c20-14(21)9-11-4-6-12(7-5-11)10-22-16-19-18-15(23-16)13-3-1-2-8-17-13/h1-8H,9-10H2,(H,20,21)
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n/an/a>2.50E+5n/an/an/an/a7.022



Novo Nordisk A/S



Assay Description
In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam...


Bioorg Med Chem Lett 12: 1525-8 (2002)


Article DOI: 10.1016/s0960-894x(02)00169-5
BindingDB Entry DOI: 10.7270/Q2251GDH
More data for this
Ligand-Target Pair
Axin-1/Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM8547
PNG
(4-({[5-(pyridin-4-yl)-1,3,4-oxadiazol-2-yl]sulfany...)
Show SMILES OC(=O)c1ccc(CSc2nnc(o2)-c2ccncc2)cc1
Show InChI InChI=1S/C15H11N3O3S/c19-14(20)12-3-1-10(2-4-12)9-22-15-18-17-13(21-15)11-5-7-16-8-6-11/h1-8H,9H2,(H,19,20)
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n/an/a 2.90E+4n/an/an/an/a7.022



Novo Nordisk A/S



Assay Description
In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam...


Bioorg Med Chem Lett 12: 1525-8 (2002)


Article DOI: 10.1016/s0960-894x(02)00169-5
BindingDB Entry DOI: 10.7270/Q2251GDH
More data for this
Ligand-Target Pair
Axin-1/Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM8548
PNG
(2-(benzylsulfanyl)-5-(pyridin-4-yl)-1,3,4-oxadiazo...)
Show SMILES C(Sc1nnc(o1)-c1ccncc1)c1ccccc1
Show InChI InChI=1S/C14H11N3OS/c1-2-4-11(5-3-1)10-19-14-17-16-13(18-14)12-6-8-15-9-7-12/h1-9H,10H2
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n/an/a 6.70E+3n/an/an/an/a7.022



Novo Nordisk A/S



Assay Description
In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam...


Bioorg Med Chem Lett 12: 1525-8 (2002)


Article DOI: 10.1016/s0960-894x(02)00169-5
BindingDB Entry DOI: 10.7270/Q2251GDH
More data for this
Ligand-Target Pair
Axin-1/Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM8549
PNG
(2-[(2-phenylethyl)sulfanyl]-5-(pyridin-4-yl)-1,3,4...)
Show SMILES C(Cc1ccccc1)Sc1nnc(o1)-c1ccncc1
Show InChI InChI=1S/C15H13N3OS/c1-2-4-12(5-3-1)8-11-20-15-18-17-14(19-15)13-6-9-16-10-7-13/h1-7,9-10H,8,11H2
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n/an/a 2.90E+4n/an/an/an/a7.022



Novo Nordisk A/S



Assay Description
In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam...


Bioorg Med Chem Lett 12: 1525-8 (2002)


Article DOI: 10.1016/s0960-894x(02)00169-5
BindingDB Entry DOI: 10.7270/Q2251GDH
More data for this
Ligand-Target Pair
Axin-1/Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM8550
PNG
(2-{[(3-chlorophenyl)methyl]sulfanyl}-5-(pyridin-4-...)
Show SMILES Clc1cccc(CSc2nnc(o2)-c2ccncc2)c1
Show InChI InChI=1S/C14H10ClN3OS/c15-12-3-1-2-10(8-12)9-20-14-18-17-13(19-14)11-4-6-16-7-5-11/h1-8H,9H2
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n/an/a 820n/an/an/an/a7.022



Novo Nordisk A/S



Assay Description
In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam...


Bioorg Med Chem Lett 12: 1525-8 (2002)


Article DOI: 10.1016/s0960-894x(02)00169-5
BindingDB Entry DOI: 10.7270/Q2251GDH
More data for this
Ligand-Target Pair
Axin-1/Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM8551
PNG
(2-{[(2-chlorophenyl)methyl]sulfanyl}-5-(pyridin-4-...)
Show SMILES Clc1ccccc1CSc1nnc(o1)-c1ccncc1
Show InChI InChI=1S/C14H10ClN3OS/c15-12-4-2-1-3-11(12)9-20-14-18-17-13(19-14)10-5-7-16-8-6-10/h1-8H,9H2
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n/an/a 1.20E+4n/an/an/an/a7.022



Novo Nordisk A/S



Assay Description
In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam...


Bioorg Med Chem Lett 12: 1525-8 (2002)


Article DOI: 10.1016/s0960-894x(02)00169-5
BindingDB Entry DOI: 10.7270/Q2251GDH
More data for this
Ligand-Target Pair
Axin-1/Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM8552
PNG
(2-{[(3-iodophenyl)methyl]sulfanyl}-5-(pyridin-4-yl...)
Show SMILES Ic1cccc(CSc2nnc(o2)-c2ccncc2)c1
Show InChI InChI=1S/C14H10IN3OS/c15-12-3-1-2-10(8-12)9-20-14-18-17-13(19-14)11-4-6-16-7-5-11/h1-8H,9H2
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n/an/a 390n/an/an/an/a7.022



Novo Nordisk A/S



Assay Description
In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam...


Bioorg Med Chem Lett 12: 1525-8 (2002)


Article DOI: 10.1016/s0960-894x(02)00169-5
BindingDB Entry DOI: 10.7270/Q2251GDH
More data for this
Ligand-Target Pair
Axin-1/Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM8553
PNG
(2-{[(4-iodophenyl)methyl]sulfanyl}-5-(pyridin-4-yl...)
Show SMILES Ic1ccc(CSc2nnc(o2)-c2ccncc2)cc1
Show InChI InChI=1S/C14H10IN3OS/c15-12-3-1-10(2-4-12)9-20-14-18-17-13(19-14)11-5-7-16-8-6-11/h1-8H,9H2
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n/an/a 1.98E+5n/an/an/an/a7.022



Novo Nordisk A/S



Assay Description
In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam...


Bioorg Med Chem Lett 12: 1525-8 (2002)


Article DOI: 10.1016/s0960-894x(02)00169-5
BindingDB Entry DOI: 10.7270/Q2251GDH
More data for this
Ligand-Target Pair
Axin-1/Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM8554
PNG
(2-{[(3-fluorophenyl)methyl]sulfanyl}-5-(pyridin-4-...)
Show SMILES Fc1cccc(CSc2nnc(o2)-c2ccncc2)c1
Show InChI InChI=1S/C14H10FN3OS/c15-12-3-1-2-10(8-12)9-20-14-18-17-13(19-14)11-4-6-16-7-5-11/h1-8H,9H2
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n/an/a 1.40E+3n/an/an/an/a7.022



Novo Nordisk A/S



Assay Description
In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam...


Bioorg Med Chem Lett 12: 1525-8 (2002)


Article DOI: 10.1016/s0960-894x(02)00169-5
BindingDB Entry DOI: 10.7270/Q2251GDH
More data for this
Ligand-Target Pair
Axin-1/Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM8555
PNG
(methyl 3-({[5-(pyridin-4-yl)-1,3,4-oxadiazol-2-yl]...)
Show SMILES COC(=O)c1cccc(CSc2nnc(o2)-c2ccncc2)c1
Show InChI InChI=1S/C16H13N3O3S/c1-21-15(20)13-4-2-3-11(9-13)10-23-16-19-18-14(22-16)12-5-7-17-8-6-12/h2-9H,10H2,1H3
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n/an/a 1.10E+3n/an/an/an/a7.022



Novo Nordisk A/S



Assay Description
In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam...


Bioorg Med Chem Lett 12: 1525-8 (2002)


Article DOI: 10.1016/s0960-894x(02)00169-5
BindingDB Entry DOI: 10.7270/Q2251GDH
More data for this
Ligand-Target Pair
Axin-1/Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM8556
PNG
(3-({[5-(pyridin-4-yl)-1,3,4-oxadiazol-2-yl]sulfany...)
Show SMILES OC(=O)c1cccc(CSc2nnc(o2)-c2ccncc2)c1
Show InChI InChI=1S/C15H11N3O3S/c19-14(20)12-3-1-2-10(8-12)9-22-15-18-17-13(21-15)11-4-6-16-7-5-11/h1-8H,9H2,(H,19,20)
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n/an/a 2.35E+5n/an/an/an/a7.022



Novo Nordisk A/S



Assay Description
In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam...


Bioorg Med Chem Lett 12: 1525-8 (2002)


Article DOI: 10.1016/s0960-894x(02)00169-5
BindingDB Entry DOI: 10.7270/Q2251GDH
More data for this
Ligand-Target Pair
Axin-1/Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM251572
PNG
(US9452998, Table 4 Compound 2)
Show SMILES NC1CCN(CC1)c1ccncc1NC(=O)c1nc(cnc1N)-c1ccccc1F
Show InChI InChI=1S/C21H22FN7O/c22-15-4-2-1-3-14(15)16-12-26-20(24)19(27-16)21(30)28-17-11-25-8-5-18(17)29-9-6-13(23)7-10-29/h1-5,8,11-13H,6-7,9-10,23H2,(H2,24,26)(H,28,30)
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US Patent
n/an/a 0.100n/an/an/an/a7.025



Novartis AG

US Patent


Assay Description
Types of GSK-3 assay used to test the selectivity/off target potential compounds of the invention with respect to PKC α/θ inhibition activity inclu...


US Patent US9452998 (2016)


BindingDB Entry DOI: 10.7270/Q2C82870
More data for this
Ligand-Target Pair
Axin-1/Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM8564
PNG
(2-cyclopentyl-N-[6-(4-methoxyphenyl)furo[2,3-d]pyr...)
Show SMILES COc1ccc(cc1)-c1cc2c(NC(=O)CC3CCCC3)ncnc2o1
Show InChI InChI=1S/C20H21N3O3/c1-25-15-8-6-14(7-9-15)17-11-16-19(21-12-22-20(16)26-17)23-18(24)10-13-4-2-3-5-13/h6-9,11-13H,2-5,10H2,1H3,(H,21,22,23,24)
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PubMed
n/an/a 324n/an/an/an/a7.222



Tsukuba Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...


Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Axin-1/Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM8565
PNG
(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 10 | N-[6-...)
Show SMILES COc1ccc(cc1)-c1cc2c(NC(=O)C3CCCCC3)ncnc2o1
Show InChI InChI=1S/C20H21N3O3/c1-25-15-9-7-13(8-10-15)17-11-16-18(21-12-22-20(16)26-17)23-19(24)14-5-3-2-4-6-14/h7-12,14H,2-6H2,1H3,(H,21,22,23,24)
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PubMed
n/an/a 1.82E+3n/an/an/an/a7.222



Tsukuba Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...


Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Axin-1/Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM8566
PNG
(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 11 | N-[6-...)
Show SMILES COc1ccc(cc1)-c1cc2c(NC(=O)N3CCOCC3)ncnc2o1
Show InChI InChI=1S/C18H18N4O4/c1-24-13-4-2-12(3-5-13)15-10-14-16(19-11-20-17(14)26-15)21-18(23)22-6-8-25-9-7-22/h2-5,10-11H,6-9H2,1H3,(H,19,20,21,23)
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PubMed
n/an/a>3.40E+4n/an/an/an/a7.222



Tsukuba Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...


Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Axin-1/Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM8567
PNG
(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 12 | N-[6-...)
Show SMILES COc1ccc(cc1)-c1cc2c(NC(=O)N3CCCC3)ncnc2o1
Show InChI InChI=1S/C18H18N4O3/c1-24-13-6-4-12(5-7-13)15-10-14-16(19-11-20-17(14)25-15)21-18(23)22-8-2-3-9-22/h4-7,10-11H,2-3,8-9H2,1H3,(H,19,20,21,23)
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PubMed
n/an/a 1.95E+3n/an/an/an/a7.222



Tsukuba Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...


Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Axin-1/Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM8568
PNG
(3-fluoro-N-[6-(4-methoxyphenyl)furo[2,3-d]pyrimidi...)
Show SMILES COc1ccc(cc1)-c1cc2c(NC(=O)c3cccc(F)c3)ncnc2o1
Show InChI InChI=1S/C20H14FN3O3/c1-26-15-7-5-12(6-8-15)17-10-16-18(22-11-23-20(16)27-17)24-19(25)13-3-2-4-14(21)9-13/h2-11H,1H3,(H,22,23,24,25)
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PubMed
n/an/a>3.50E+4n/an/an/an/a7.222



Tsukuba Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...


Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Axin-1/Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM8569
PNG
(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 14 | N-[6-...)
Show SMILES COc1ccc(cc1)-c1cc2c(NC(=O)c3ccco3)ncnc2o1
Show InChI InChI=1S/C18H13N3O4/c1-23-12-6-4-11(5-7-12)15-9-13-16(19-10-20-18(13)25-15)21-17(22)14-3-2-8-24-14/h2-10H,1H3,(H,19,20,21,22)
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PubMed
n/an/a 2.40E+3n/an/an/an/a7.222



Tsukuba Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...


Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Axin-1/Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM8570
PNG
(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 15 | N-{6-...)
Show SMILES O=C(Nc1ncnc2oc(cc12)-c1ccccc1)C1CC1
Show InChI InChI=1S/C16H13N3O2/c20-15(11-6-7-11)19-14-12-8-13(10-4-2-1-3-5-10)21-16(12)18-9-17-14/h1-5,8-9,11H,6-7H2,(H,17,18,19,20)
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PubMed
n/an/a 174n/an/an/an/a7.222



Tsukuba Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...


Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Axin-1/Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM8571
PNG
(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 16 | N-[6-...)
Show SMILES Clc1ccc(cc1)-c1cc2c(NC(=O)C3CC3)ncnc2o1
Show InChI InChI=1S/C16H12ClN3O2/c17-11-5-3-9(4-6-11)13-7-12-14(18-8-19-16(12)22-13)20-15(21)10-1-2-10/h3-8,10H,1-2H2,(H,18,19,20,21)
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PubMed
n/an/a 1.00E+3n/an/an/an/a7.222



Tsukuba Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...


Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Axin-1/Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM8572
PNG
(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 17 | N-[6-...)
Show SMILES Cc1ccc(cc1)-c1cc2c(NC(=O)C3CC3)ncnc2o1
Show InChI InChI=1S/C17H15N3O2/c1-10-2-4-11(5-3-10)14-8-13-15(18-9-19-17(13)22-14)20-16(21)12-6-7-12/h2-5,8-9,12H,6-7H2,1H3,(H,18,19,20,21)
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n/an/a 617n/an/an/an/a7.222



Tsukuba Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...


Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Axin-1/Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM8573
PNG
(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 18 | N-[6-...)
Show SMILES Fc1ccc(cc1)-c1cc2c(NC(=O)C3CC3)ncnc2o1
Show InChI InChI=1S/C16H12FN3O2/c17-11-5-3-9(4-6-11)13-7-12-14(18-8-19-16(12)22-13)20-15(21)10-1-2-10/h3-8,10H,1-2H2,(H,18,19,20,21)
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PubMed
n/an/a 575n/an/an/an/a7.222



Tsukuba Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...


Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Axin-1/Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM8574
PNG
(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 19 | N-[6-...)
Show SMILES O=C(Nc1ncnc2oc(cc12)-c1cccnc1)C1CC1
Show InChI InChI=1S/C15H12N4O2/c20-14(9-3-4-9)19-13-11-6-12(10-2-1-5-16-7-10)21-15(11)18-8-17-13/h1-2,5-9H,3-4H2,(H,17,18,19,20)
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PubMed
n/an/a 5n/an/an/an/a7.222



Tsukuba Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...


Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
Axin-1/Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM8575
PNG
(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 20 | N-{6-...)
Show SMILES O=C(Nc1ncnc2oc(cc12)-c1ccccc1)C1CCCC1
Show InChI InChI=1S/C18H17N3O2/c22-17(13-8-4-5-9-13)21-16-14-10-15(12-6-2-1-3-7-12)23-18(14)20-11-19-16/h1-3,6-7,10-11,13H,4-5,8-9H2,(H,19,20,21,22)
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PubMed
n/an/a 23n/an/an/an/a7.222



Tsukuba Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...


Bioorg Med Chem Lett 14: 3907-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.064
BindingDB Entry DOI: 10.7270/Q2XD0ZWC
More data for this
Ligand-Target Pair
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