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Compile Data Set for Download or QSAR

Found 101 hits Enz. Inhib. hit(s) with Target = 'BRAF-MEK-ERK'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
BRAF-MEK-ERK


(Homo sapiens (human))
BDBM200372
PNG
(US9227969, 1A)
Show SMILES Cc1nc2cnc3cc(F)c(cc3c2n1[C@H]1CCN(C[C@@H]1F)C(=O)CO)-c1ccc(Oc2ncccn2)cc1Cl
Show InChI InChI=1S/C28H23ClF2N6O3/c1-15-35-24-12-34-23-11-21(30)18(17-4-3-16(9-20(17)29)40-28-32-6-2-7-33-28)10-19(23)27(24)37(15)25-5-8-36(13-22(25)31)26(39)14-38/h2-4,6-7,9-12,22,25,38H,5,8,13-14H2,1H3/t22-,25-/m0/s1
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n/an/a 5n/an/an/an/a7.5n/a



NOVARTIS AG

US Patent


Assay Description
A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...


US Patent US9227969 (2016)


BindingDB Entry DOI: 10.7270/Q2W094RM
More data for this
Ligand-Target Pair
BRAF-MEK-ERK


(Homo sapiens (human))
BDBM200373
PNG
(US9227969, 1B)
Show SMILES Cc1nc2cnc3cc(F)c(cc3c2n1C1CCN(C[C@H]1F)C(=O)CO)-c1ccc(Oc2ncccn2)cc1Cl
Show InChI InChI=1S/C28H23ClF2N6O3/c1-15-35-24-12-34-23-11-21(30)18(17-4-3-16(9-20(17)29)40-28-32-6-2-7-33-28)10-19(23)27(24)37(15)25-5-8-36(13-22(25)31)26(39)14-38/h2-4,6-7,9-12,22,25,38H,5,8,13-14H2,1H3/t22-,25?/m1/s1
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n/an/a 138n/an/an/an/a7.5n/a



NOVARTIS AG

US Patent


Assay Description
A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...


US Patent US9227969 (2016)


BindingDB Entry DOI: 10.7270/Q2W094RM
More data for this
Ligand-Target Pair
BRAF-MEK-ERK


(Homo sapiens (human))
BDBM200374
PNG
(US9227969, 2)
Show SMILES COCCN1CCC(CC1)n1c(C)nc2cnc3cc(F)c(cc3c12)-c1ccc(Oc2ncccn2)cc1Cl
Show InChI InChI=1S/C29H28ClFN6O2/c1-18-35-27-17-34-26-16-25(31)22(21-5-4-20(14-24(21)30)39-29-32-8-3-9-33-29)15-23(26)28(27)37(18)19-6-10-36(11-7-19)12-13-38-2/h3-5,8-9,14-17,19H,6-7,10-13H2,1-2H3
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n/an/a 726n/an/an/an/a7.5n/a



NOVARTIS AG

US Patent


Assay Description
A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...


US Patent US9227969 (2016)


BindingDB Entry DOI: 10.7270/Q2W094RM
More data for this
Ligand-Target Pair
BRAF-MEK-ERK


(Homo sapiens (human))
BDBM200375
PNG
(US9227969, 3)
Show SMILES Cc1nc2cnc3cc(F)c(cc3c2n1C1CCN(CCO)CC1)-c1ccc(Oc2ncccn2)cc1Cl
Show InChI InChI=1S/C28H26ClFN6O2/c1-17-34-26-16-33-25-15-24(30)21(20-4-3-19(13-23(20)29)38-28-31-7-2-8-32-28)14-22(25)27(26)36(17)18-5-9-35(10-6-18)11-12-37/h2-4,7-8,13-16,18,37H,5-6,9-12H2,1H3
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n/an/a 104n/an/an/an/a7.5n/a



NOVARTIS AG

US Patent


Assay Description
A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...


US Patent US9227969 (2016)


BindingDB Entry DOI: 10.7270/Q2W094RM
More data for this
Ligand-Target Pair
BRAF-MEK-ERK


(Homo sapiens (human))
BDBM200376
PNG
(US9227969, 4)
Show SMILES Cc1nc2cnc3cc(F)c(cc3c2n1C1CCN(CC2(C)COC2)CC1)-c1ccc(Oc2ncccn2)cc1Cl
Show InChI InChI=1S/C31H30ClFN6O2/c1-19-37-28-15-36-27-14-26(33)23(22-5-4-21(12-25(22)32)41-30-34-8-3-9-35-30)13-24(27)29(28)39(19)20-6-10-38(11-7-20)16-31(2)17-40-18-31/h3-5,8-9,12-15,20H,6-7,10-11,16-18H2,1-2H3
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n/an/a 309n/an/an/an/a7.5n/a



NOVARTIS AG

US Patent


Assay Description
A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...


US Patent US9227969 (2016)


BindingDB Entry DOI: 10.7270/Q2W094RM
More data for this
Ligand-Target Pair
BRAF-MEK-ERK


(Homo sapiens (human))
BDBM200377
PNG
(US9227969, 5)
Show SMILES Cc1nc2cnc3cc(F)c(cc3c2n1C1CCN(CC1)S(C)(=O)=O)-c1ccc(Oc2ncccn2)cc1Cl
Show InChI InChI=1S/C27H24ClFN6O3S/c1-16-33-25-15-32-24-14-23(29)20(19-5-4-18(12-22(19)28)38-27-30-8-3-9-31-27)13-21(24)26(25)35(16)17-6-10-34(11-7-17)39(2,36)37/h3-5,8-9,12-15,17H,6-7,10-11H2,1-2H3
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n/an/a 40n/an/an/an/a7.5n/a



NOVARTIS AG

US Patent


Assay Description
A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...


US Patent US9227969 (2016)


BindingDB Entry DOI: 10.7270/Q2W094RM
More data for this
Ligand-Target Pair
BRAF-MEK-ERK


(Homo sapiens (human))
BDBM200378
PNG
(US9227969, 6)
Show SMILES CC(O)C(=O)N1CCC(CC1)n1c(C)nc2cnc3cc(F)c(cc3c12)-c1ccc(Oc2ncccn2)cc1Cl
Show InChI InChI=1S/C29H26ClFN6O3/c1-16(38)28(39)36-10-6-18(7-11-36)37-17(2)35-26-15-34-25-14-24(31)21(13-22(25)27(26)37)20-5-4-19(12-23(20)30)40-29-32-8-3-9-33-29/h3-5,8-9,12-16,18,38H,6-7,10-11H2,1-2H3
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n/an/a 62n/an/an/an/a7.5n/a



NOVARTIS AG

US Patent


Assay Description
A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...


US Patent US9227969 (2016)


BindingDB Entry DOI: 10.7270/Q2W094RM
More data for this
Ligand-Target Pair
BRAF-MEK-ERK


(Homo sapiens (human))
BDBM200379
PNG
(US9227969, 7)
Show SMILES CC(O)CN1CCC(CC1)n1c(C)nc2cnc3cc(F)c(cc3c12)-c1ccc(Oc2ncccn2)cc1Cl
Show InChI InChI=1S/C29H28ClFN6O2/c1-17(38)16-36-10-6-19(7-11-36)37-18(2)35-27-15-34-26-14-25(31)22(13-23(26)28(27)37)21-5-4-20(12-24(21)30)39-29-32-8-3-9-33-29/h3-5,8-9,12-15,17,19,38H,6-7,10-11,16H2,1-2H3
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n/an/a 468n/an/an/an/a7.5n/a



NOVARTIS AG

US Patent


Assay Description
A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...


US Patent US9227969 (2016)


BindingDB Entry DOI: 10.7270/Q2W094RM
More data for this
Ligand-Target Pair
BRAF-MEK-ERK


(Homo sapiens (human))
BDBM200380
PNG
(US9227969, 8)
Show SMILES Cc1nc2cnc3cc(F)c(cc3c2n1C1CCN(CC1)S(=O)(=O)C1CC1)-c1ccc(Oc2ncccn2)cc1Cl
Show InChI InChI=1S/C29H26ClFN6O3S/c1-17-35-27-16-34-26-15-25(31)22(21-6-3-19(13-24(21)30)40-29-32-9-2-10-33-29)14-23(26)28(27)37(17)18-7-11-36(12-8-18)41(38,39)20-4-5-20/h2-3,6,9-10,13-16,18,20H,4-5,7-8,11-12H2,1H3
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n/an/a 15n/an/an/an/a7.5n/a



NOVARTIS AG

US Patent


Assay Description
A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...


US Patent US9227969 (2016)


BindingDB Entry DOI: 10.7270/Q2W094RM
More data for this
Ligand-Target Pair
BRAF-MEK-ERK


(Homo sapiens (human))
BDBM200381
PNG
(US9227969, 9)
Show SMILES CC(C)S(=O)(=O)N1CCC(CC1)n1c(C)nc2cnc3cc(F)c(cc3c12)-c1ccc(Oc2ncccn2)cc1Cl
Show InChI InChI=1S/C29H28ClFN6O3S/c1-17(2)41(38,39)36-11-7-19(8-12-36)37-18(3)35-27-16-34-26-15-25(31)22(14-23(26)28(27)37)21-6-5-20(13-24(21)30)40-29-32-9-4-10-33-29/h4-6,9-10,13-17,19H,7-8,11-12H2,1-3H3
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n/an/a 103n/an/an/an/a7.5n/a



NOVARTIS AG

US Patent


Assay Description
A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...


US Patent US9227969 (2016)


BindingDB Entry DOI: 10.7270/Q2W094RM
More data for this
Ligand-Target Pair
BRAF-MEK-ERK


(Homo sapiens (human))
BDBM200382
PNG
(US9227969, 10)
Show SMILES CN(C)S(=O)(=O)N1CCC(CC1)n1c(C)nc2cnc3cc(F)c(cc3c12)-c1ccc(Oc2ncccn2)cc1Cl
Show InChI InChI=1S/C28H27ClFN7O3S/c1-17-34-26-16-33-25-15-24(30)21(20-6-5-19(13-23(20)29)40-28-31-9-4-10-32-28)14-22(25)27(26)37(17)18-7-11-36(12-8-18)41(38,39)35(2)3/h4-6,9-10,13-16,18H,7-8,11-12H2,1-3H3
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NOVARTIS AG

US Patent


Assay Description
A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...


US Patent US9227969 (2016)


BindingDB Entry DOI: 10.7270/Q2W094RM
More data for this
Ligand-Target Pair
BRAF-MEK-ERK


(Homo sapiens (human))
BDBM200383
PNG
(US9227969, 11)
Show SMILES CN(C)C(=O)N1CCC(CC1)n1c(C)nc2cnc3cc(F)c(cc3c12)-c1ccc(Oc2ncccn2)cc1Cl
Show InChI InChI=1S/C29H27ClFN7O2/c1-17-35-26-16-34-25-15-24(31)21(20-6-5-19(13-23(20)30)40-28-32-9-4-10-33-28)14-22(25)27(26)38(17)18-7-11-37(12-8-18)29(39)36(2)3/h4-6,9-10,13-16,18H,7-8,11-12H2,1-3H3
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n/an/a 2.35E+3n/an/an/an/a7.5n/a



NOVARTIS AG

US Patent


Assay Description
A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...


US Patent US9227969 (2016)


BindingDB Entry DOI: 10.7270/Q2W094RM
More data for this
Ligand-Target Pair
BRAF-MEK-ERK


(Homo sapiens (human))
BDBM200384
PNG
(US9227969, 12)
Show SMILES CC(=O)N1CCC(CC1)n1c(C)nc2cnc3cc(F)c(cc3c12)-c1ccc(Oc2ncccn2)cc1Cl
Show InChI InChI=1S/C28H24ClFN6O2/c1-16-34-26-15-33-25-14-24(30)21(20-5-4-19(12-23(20)29)38-28-31-8-3-9-32-28)13-22(25)27(26)36(16)18-6-10-35(11-7-18)17(2)37/h3-5,8-9,12-15,18H,6-7,10-11H2,1-2H3
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NOVARTIS AG

US Patent


Assay Description
A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...


US Patent US9227969 (2016)


BindingDB Entry DOI: 10.7270/Q2W094RM
More data for this
Ligand-Target Pair
BRAF-MEK-ERK


(Homo sapiens (human))
BDBM200385
PNG
(US9227969, 13)
Show SMILES Cc1nc2cnc3cc(F)c(cc3c2n1C1CCN(CC(N)=O)CC1)-c1ccc(Oc2ncccn2)cc1Cl
Show InChI InChI=1S/C28H25ClFN7O2/c1-16-35-25-14-34-24-13-23(30)20(19-4-3-18(11-22(19)29)39-28-32-7-2-8-33-28)12-21(24)27(25)37(16)17-5-9-36(10-6-17)15-26(31)38/h2-4,7-8,11-14,17H,5-6,9-10,15H2,1H3,(H2,31,38)
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NOVARTIS AG

US Patent


Assay Description
A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...


US Patent US9227969 (2016)


BindingDB Entry DOI: 10.7270/Q2W094RM
More data for this
Ligand-Target Pair
BRAF-MEK-ERK


(Homo sapiens (human))
BDBM200386
PNG
(US9227969, 14)
Show SMILES Cc1nc2cnc3cc(F)c(cc3c2n1C1CCN(CC1)C(=O)CO)-c1ccc(Oc2ncccn2)cc1Cl
Show InChI InChI=1S/C28H24ClFN6O3/c1-16-34-25-14-33-24-13-23(30)20(19-4-3-18(11-22(19)29)39-28-31-7-2-8-32-28)12-21(24)27(25)36(16)17-5-9-35(10-6-17)26(38)15-37/h2-4,7-8,11-14,17,37H,5-6,9-10,15H2,1H3
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NOVARTIS AG

US Patent


Assay Description
A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...


US Patent US9227969 (2016)


BindingDB Entry DOI: 10.7270/Q2W094RM
More data for this
Ligand-Target Pair
BRAF-MEK-ERK


(Homo sapiens (human))
BDBM200387
PNG
(US9227969, 15)
Show SMILES Cc1ccnc(Oc2ccc(c(Cl)c2)-c2cc3c4n(cnc4cnc3cc2F)C2(C)CCN(CCO)CC2)n1
Show InChI InChI=1S/C29H28ClFN6O2/c1-18-5-8-32-28(35-18)39-19-3-4-20(23(30)13-19)21-14-22-25(15-24(21)31)33-16-26-27(22)37(17-34-26)29(2)6-9-36(10-7-29)11-12-38/h3-5,8,13-17,38H,6-7,9-12H2,1-2H3
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NOVARTIS AG

US Patent


Assay Description
A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...


US Patent US9227969 (2016)


BindingDB Entry DOI: 10.7270/Q2W094RM
More data for this
Ligand-Target Pair
BRAF-MEK-ERK


(Homo sapiens (human))
BDBM200388
PNG
(US9227969, 16)
Show SMILES CC(CO)N1CCC(CC1)n1c(C)nc2cnc3cc(F)c(cc3c12)-c1ccc(Oc2ncccn2)cc1Cl
Show InChI InChI=1S/C29H28ClFN6O2/c1-17(16-38)36-10-6-19(7-11-36)37-18(2)35-27-15-34-26-14-25(31)22(13-23(26)28(27)37)21-5-4-20(12-24(21)30)39-29-32-8-3-9-33-29/h3-5,8-9,12-15,17,19,38H,6-7,10-11,16H2,1-2H3
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NOVARTIS AG

US Patent


Assay Description
A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...


US Patent US9227969 (2016)


BindingDB Entry DOI: 10.7270/Q2W094RM
More data for this
Ligand-Target Pair
BRAF-MEK-ERK


(Homo sapiens (human))
BDBM200389
PNG
(US9227969, 17)
Show SMILES CC1(CCN(CCO)CC1)n1cnc2cnc3cc(F)c(cc3c12)-c1ccc(Oc2ncccn2)cc1Cl
Show InChI InChI=1S/C28H26ClFN6O2/c1-28(5-9-35(10-6-28)11-12-37)36-17-34-25-16-33-24-15-23(30)20(14-21(24)26(25)36)19-4-3-18(13-22(19)29)38-27-31-7-2-8-32-27/h2-4,7-8,13-17,37H,5-6,9-12H2,1H3
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NOVARTIS AG

US Patent


Assay Description
A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...


US Patent US9227969 (2016)


BindingDB Entry DOI: 10.7270/Q2W094RM
More data for this
Ligand-Target Pair
BRAF-MEK-ERK


(Homo sapiens (human))
BDBM200390
PNG
(US9227969, 18)
Show SMILES COc1cc(Oc2nccc(C)n2)ccc1-c1cc2c3n(cnc3cnc2cc1F)C1(C)CCN(CCO)CC1
Show InChI InChI=1S/C30H31FN6O3/c1-19-6-9-32-29(35-19)40-20-4-5-21(27(14-20)39-3)22-15-23-25(16-24(22)31)33-17-26-28(23)37(18-34-26)30(2)7-10-36(11-8-30)12-13-38/h4-6,9,14-18,38H,7-8,10-13H2,1-3H3
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NOVARTIS AG

US Patent


Assay Description
A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...


US Patent US9227969 (2016)


BindingDB Entry DOI: 10.7270/Q2W094RM
More data for this
Ligand-Target Pair
BRAF-MEK-ERK


(Homo sapiens (human))
BDBM200391
PNG
(US9227969, 19)
Show SMILES COc1cc(Oc2ncccn2)ccc1-c1cc2c3n(cnc3cnc2cc1F)C1(C)CCN(CCO)CC1
Show InChI InChI=1S/C29H29FN6O3/c1-29(6-10-35(11-7-29)12-13-37)36-18-34-25-17-33-24-16-23(30)21(15-22(24)27(25)36)20-5-4-19(14-26(20)38-2)39-28-31-8-3-9-32-28/h3-5,8-9,14-18,37H,6-7,10-13H2,1-2H3
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n/an/a 333n/an/an/an/a7.5n/a



NOVARTIS AG

US Patent


Assay Description
A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...


US Patent US9227969 (2016)


BindingDB Entry DOI: 10.7270/Q2W094RM
More data for this
Ligand-Target Pair
BRAF-MEK-ERK


(Homo sapiens (human))
BDBM200392
PNG
(US9227969, 20)
Show SMILES COc1cc(Oc2nccc(C)n2)ccc1-c1cc2c3n(cnc3cnc2cc1F)C1(C)CCN(CC1)C(=O)C(C)O
Show InChI InChI=1S/C31H31FN6O4/c1-18-7-10-33-30(36-18)42-20-5-6-21(27(13-20)41-4)22-14-23-25(15-24(22)32)34-16-26-28(23)38(17-35-26)31(3)8-11-37(12-9-31)29(40)19(2)39/h5-7,10,13-17,19,39H,8-9,11-12H2,1-4H3
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n/an/a 157n/an/an/an/a7.5n/a



NOVARTIS AG

US Patent


Assay Description
A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...


US Patent US9227969 (2016)


BindingDB Entry DOI: 10.7270/Q2W094RM
More data for this
Ligand-Target Pair
BRAF-MEK-ERK


(Homo sapiens (human))
BDBM200393
PNG
(US9227969, 21)
Show SMILES CC(O)C(=O)N1CCC(C)(CC1)n1cnc2cnc3cc(F)c(cc3c12)-c1ccc(Oc2nccc(C)n2)cc1Cl
Show InChI InChI=1S/C30H28ClFN6O3/c1-17-6-9-33-29(36-17)41-19-4-5-20(23(31)12-19)21-13-22-25(14-24(21)32)34-15-26-27(22)38(16-35-26)30(3)7-10-37(11-8-30)28(40)18(2)39/h4-6,9,12-16,18,39H,7-8,10-11H2,1-3H3
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NOVARTIS AG

US Patent


Assay Description
A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...


US Patent US9227969 (2016)


BindingDB Entry DOI: 10.7270/Q2W094RM
More data for this
Ligand-Target Pair
BRAF-MEK-ERK


(Homo sapiens (human))
BDBM200394
PNG
(US9227969, 22)
Show SMILES Cc1nc2cnc3cc(F)c(cc3c2n1C1CCN(CC1)C(=O)C(CO)CO)-c1ccc(Oc2ncccn2)cc1Cl
Show InChI InChI=1S/C30H28ClFN6O4/c1-17-36-27-14-35-26-13-25(32)22(21-4-3-20(11-24(21)31)42-30-33-7-2-8-34-30)12-23(26)28(27)38(17)19-5-9-37(10-6-19)29(41)18(15-39)16-40/h2-4,7-8,11-14,18-19,39-40H,5-6,9-10,15-16H2,1H3
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NOVARTIS AG

US Patent


Assay Description
A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...


US Patent US9227969 (2016)


BindingDB Entry DOI: 10.7270/Q2W094RM
More data for this
Ligand-Target Pair
BRAF-MEK-ERK


(Homo sapiens (human))
BDBM200395
PNG
(US9227969, 23)
Show SMILES Cc1nc2cnc3cc(F)c(cc3c2n1C1CCN(CC(CO)CO)CC1)-c1ccc(Oc2ncccn2)cc1Cl
Show InChI InChI=1S/C30H30ClFN6O3/c1-18-36-28-14-35-27-13-26(32)23(22-4-3-21(11-25(22)31)41-30-33-7-2-8-34-30)12-24(27)29(28)38(18)20-5-9-37(10-6-20)15-19(16-39)17-40/h2-4,7-8,11-14,19-20,39-40H,5-6,9-10,15-17H2,1H3
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NOVARTIS AG

US Patent


Assay Description
A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...


US Patent US9227969 (2016)


BindingDB Entry DOI: 10.7270/Q2W094RM
More data for this
Ligand-Target Pair
BRAF-MEK-ERK


(Homo sapiens (human))
BDBM200396
PNG
(US9227969, 24)
Show SMILES COc1cc(Oc2nccc(C)n2)ccc1-c1cc2c3n(cnc3cnc2cc1F)C1(C)CCN(CC1)C(=O)CO
Show InChI InChI=1S/C30H29FN6O4/c1-18-6-9-32-29(35-18)41-19-4-5-20(26(12-19)40-3)21-13-22-24(14-23(21)31)33-15-25-28(22)37(17-34-25)30(2)7-10-36(11-8-30)27(39)16-38/h4-6,9,12-15,17,38H,7-8,10-11,16H2,1-3H3
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NOVARTIS AG

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Assay Description
A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...


US Patent US9227969 (2016)


BindingDB Entry DOI: 10.7270/Q2W094RM
More data for this
Ligand-Target Pair
BRAF-MEK-ERK


(Homo sapiens (human))
BDBM200397
PNG
(US9227969, 25)
Show SMILES Cc1nc2cnc3cc(F)c(cc3c2n1C1CCN(CC2COC2)CC1)-c1ccc(Oc2ncccn2)cc1Cl
Show InChI InChI=1S/C30H28ClFN6O2/c1-18-36-28-14-35-27-13-26(32)23(22-4-3-21(11-25(22)31)40-30-33-7-2-8-34-30)12-24(27)29(28)38(18)20-5-9-37(10-6-20)15-19-16-39-17-19/h2-4,7-8,11-14,19-20H,5-6,9-10,15-17H2,1H3
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NOVARTIS AG

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Assay Description
A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...


US Patent US9227969 (2016)


BindingDB Entry DOI: 10.7270/Q2W094RM
More data for this
Ligand-Target Pair
BRAF-MEK-ERK


(Homo sapiens (human))
BDBM200398
PNG
(US9227969, 26)
Show SMILES Cc1ccnc(Oc2ccc(c(Cl)c2)-c2cc3c4n(cnc4cnc3cc2F)C2(C)CCN(CC2)C(=O)CO)n1
Show InChI InChI=1S/C29H26ClFN6O3/c1-17-5-8-32-28(35-17)40-18-3-4-19(22(30)11-18)20-12-21-24(13-23(20)31)33-14-25-27(21)37(16-34-25)29(2)6-9-36(10-7-29)26(39)15-38/h3-5,8,11-14,16,38H,6-7,9-10,15H2,1-2H3
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NOVARTIS AG

US Patent


Assay Description
A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...


US Patent US9227969 (2016)


BindingDB Entry DOI: 10.7270/Q2W094RM
More data for this
Ligand-Target Pair
BRAF-MEK-ERK


(Homo sapiens (human))
BDBM200399
PNG
(US9227969, 27)
Show SMILES CC(O)C(=O)N1CCC(C)(CC1)n1cnc2cnc3cc(F)c(cc3c12)-c1ccc(Oc2ncccn2)cc1Cl
Show InChI InChI=1S/C29H26ClFN6O3/c1-17(38)27(39)36-10-6-29(2,7-11-36)37-16-35-25-15-34-24-14-23(31)20(13-21(24)26(25)37)19-5-4-18(12-22(19)30)40-28-32-8-3-9-33-28/h3-5,8-9,12-17,38H,6-7,10-11H2,1-2H3
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NOVARTIS AG

US Patent


Assay Description
A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...


US Patent US9227969 (2016)


BindingDB Entry DOI: 10.7270/Q2W094RM
More data for this
Ligand-Target Pair
BRAF-MEK-ERK


(Homo sapiens (human))
BDBM200400
PNG
(US9227969, 28)
Show SMILES Cc1nc2cnc3cc(F)c(cc3c2n1C1CCN(CC1)C(=O)CO)-c1ccc(Oc2nccc(C)n2)cc1Cl
Show InChI InChI=1S/C29H26ClFN6O3/c1-16-5-8-32-29(34-16)40-19-3-4-20(23(30)11-19)21-12-22-25(13-24(21)31)33-14-26-28(22)37(17(2)35-26)18-6-9-36(10-7-18)27(39)15-38/h3-5,8,11-14,18,38H,6-7,9-10,15H2,1-2H3
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NOVARTIS AG

US Patent


Assay Description
A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...


US Patent US9227969 (2016)


BindingDB Entry DOI: 10.7270/Q2W094RM
More data for this
Ligand-Target Pair
BRAF-MEK-ERK


(Homo sapiens (human))
BDBM200401
PNG
(US9227969, 29)
Show SMILES CC(O)C(=O)N1CCC(CC1)n1c(C)nc2cnc3cc(F)c(cc3c12)-c1ccc(Oc2nccc(C)n2)cc1Cl
Show InChI InChI=1S/C30H28ClFN6O3/c1-16-6-9-33-30(35-16)41-20-4-5-21(24(31)12-20)22-13-23-26(14-25(22)32)34-15-27-28(23)38(18(3)36-27)19-7-10-37(11-8-19)29(40)17(2)39/h4-6,9,12-15,17,19,39H,7-8,10-11H2,1-3H3
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NOVARTIS AG

US Patent


Assay Description
A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...


US Patent US9227969 (2016)


BindingDB Entry DOI: 10.7270/Q2W094RM
More data for this
Ligand-Target Pair
BRAF-MEK-ERK


(Homo sapiens (human))
BDBM200402
PNG
(US9227969, 30)
Show SMILES Cc1nc2cnc3cc(F)c(cc3c2n1C1CCN(CC1)C(N)=O)-c1ccc(Oc2ncccn2)cc1Cl
Show InChI InChI=1S/C27H23ClFN7O2/c1-15-34-24-14-33-23-13-22(29)19(18-4-3-17(11-21(18)28)38-27-31-7-2-8-32-27)12-20(23)25(24)36(15)16-5-9-35(10-6-16)26(30)37/h2-4,7-8,11-14,16H,5-6,9-10H2,1H3,(H2,30,37)
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NOVARTIS AG

US Patent


Assay Description
A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...


US Patent US9227969 (2016)


BindingDB Entry DOI: 10.7270/Q2W094RM
More data for this
Ligand-Target Pair
BRAF-MEK-ERK


(Homo sapiens (human))
BDBM200403
PNG
(US9227969, 31)
Show SMILES Cc1nc2cnc3cc(F)c(cc3c2n1C1CCN(CC1)C(N)=O)-c1ccc(Oc2nccc(C)n2)cc1Cl
Show InChI InChI=1S/C28H25ClFN7O2/c1-15-5-8-32-28(34-15)39-18-3-4-19(22(29)11-18)20-12-21-24(13-23(20)30)33-14-25-26(21)37(16(2)35-25)17-6-9-36(10-7-17)27(31)38/h3-5,8,11-14,17H,6-7,9-10H2,1-2H3,(H2,31,38)
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NOVARTIS AG

US Patent


Assay Description
A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...


US Patent US9227969 (2016)


BindingDB Entry DOI: 10.7270/Q2W094RM
More data for this
Ligand-Target Pair
BRAF-MEK-ERK


(Homo sapiens (human))
BDBM200404
PNG
(US9227969, 32)
Show SMILES Cc1nc2cnc3cc(F)c(cc3c2n1C1CCN(CC1)S(C)(=O)=O)-c1ccc(Oc2nccc(C)n2)cc1Cl
Show InChI InChI=1S/C28H26ClFN6O3S/c1-16-6-9-31-28(33-16)39-19-4-5-20(23(29)12-19)21-13-22-25(14-24(21)30)32-15-26-27(22)36(17(2)34-26)18-7-10-35(11-8-18)40(3,37)38/h4-6,9,12-15,18H,7-8,10-11H2,1-3H3
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NOVARTIS AG

US Patent


Assay Description
A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...


US Patent US9227969 (2016)


BindingDB Entry DOI: 10.7270/Q2W094RM
More data for this
Ligand-Target Pair
BRAF-MEK-ERK


(Homo sapiens (human))
BDBM200405
PNG
(US9227969, 33)
Show SMILES CC1(CCN(CC1)C(=O)CO)n1cnc2cnc3cc(F)c(cc3c12)-c1ccc(Oc2ncccn2)cc1Cl
Show InChI InChI=1S/C28H24ClFN6O3/c1-28(5-9-35(10-6-28)25(38)15-37)36-16-34-24-14-33-23-13-22(30)19(12-20(23)26(24)36)18-4-3-17(11-21(18)29)39-27-31-7-2-8-32-27/h2-4,7-8,11-14,16,37H,5-6,9-10,15H2,1H3
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NOVARTIS AG

US Patent


Assay Description
A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...


US Patent US9227969 (2016)


BindingDB Entry DOI: 10.7270/Q2W094RM
More data for this
Ligand-Target Pair
BRAF-MEK-ERK


(Homo sapiens (human))
BDBM200406
PNG
(US9227969, 34)
Show SMILES C[C@H](O)C(=O)N1CCC(CC1)n1c(C)nc2cnc3cc(F)c(cc3c12)-c1ccc(Oc2ncccn2)cc1Cl
Show InChI InChI=1S/C29H26ClFN6O3/c1-16(38)28(39)36-10-6-18(7-11-36)37-17(2)35-26-15-34-25-14-24(31)21(13-22(25)27(26)37)20-5-4-19(12-23(20)30)40-29-32-8-3-9-33-29/h3-5,8-9,12-16,18,38H,6-7,10-11H2,1-2H3/t16-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...


US Patent US9227969 (2016)


BindingDB Entry DOI: 10.7270/Q2W094RM
More data for this
Ligand-Target Pair
BRAF-MEK-ERK


(Homo sapiens (human))
BDBM200407
PNG
(US9227969, 35)
Show SMILES C[C@H](O)C(=O)N1CCC(CC1)n1c(C)nc2cnc3cc(F)c(cc3c12)-c1ccc(Oc2nccc(C)n2)cc1Cl
Show InChI InChI=1S/C30H28ClFN6O3/c1-16-6-9-33-30(35-16)41-20-4-5-21(24(31)12-20)22-13-23-26(14-25(22)32)34-15-27-28(23)38(18(3)36-27)19-7-10-37(11-8-19)29(40)17(2)39/h4-6,9,12-15,17,19,39H,7-8,10-11H2,1-3H3/t17-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...


US Patent US9227969 (2016)


BindingDB Entry DOI: 10.7270/Q2W094RM
More data for this
Ligand-Target Pair
BRAF-MEK-ERK


(Homo sapiens (human))
BDBM200408
PNG
(US9227969, 36)
Show SMILES Cc1nc2cnc3cc(F)c(cc3c2n1C1CCN(CCO)CC1)-c1ccc(Oc2nccc(C)n2)cc1Cl
Show InChI InChI=1S/C29H28ClFN6O2/c1-17-5-8-32-29(34-17)39-20-3-4-21(24(30)13-20)22-14-23-26(15-25(22)31)33-16-27-28(23)37(18(2)35-27)19-6-9-36(10-7-19)11-12-38/h3-5,8,13-16,19,38H,6-7,9-12H2,1-2H3
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NOVARTIS AG

US Patent


Assay Description
A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...


US Patent US9227969 (2016)


BindingDB Entry DOI: 10.7270/Q2W094RM
More data for this
Ligand-Target Pair
BRAF-MEK-ERK


(Homo sapiens (human))
BDBM200409
PNG
(US9227969, 37)
Show SMILES COc1cc(Oc2nccc(C)n2)ccc1-c1cc2c3n(cnc3cnc2cc1F)C1(C)CCN(CC1)C(N)=O
Show InChI InChI=1S/C29H28FN7O3/c1-17-6-9-32-28(35-17)40-18-4-5-19(25(12-18)39-3)20-13-21-23(14-22(20)30)33-15-24-26(21)37(16-34-24)29(2)7-10-36(11-8-29)27(31)38/h4-6,9,12-16H,7-8,10-11H2,1-3H3,(H2,31,38)
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NOVARTIS AG

US Patent


Assay Description
A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...


US Patent US9227969 (2016)


BindingDB Entry DOI: 10.7270/Q2W094RM
More data for this
Ligand-Target Pair
BRAF-MEK-ERK


(Homo sapiens (human))
BDBM200410
PNG
(US9227969, 38)
Show SMILES COc1cc(Oc2ncccn2)ccc1-c1cc2c3n(cnc3cnc2cc1F)C1(C)CCN(CC1)C(N)=O
Show InChI InChI=1S/C28H26FN7O3/c1-28(6-10-35(11-7-28)26(30)37)36-16-34-23-15-33-22-14-21(29)19(13-20(22)25(23)36)18-5-4-17(12-24(18)38-2)39-27-31-8-3-9-32-27/h3-5,8-9,12-16H,6-7,10-11H2,1-2H3,(H2,30,37)
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n/an/a 4.60n/an/an/an/a7.5n/a



NOVARTIS AG

US Patent


Assay Description
A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...


US Patent US9227969 (2016)


BindingDB Entry DOI: 10.7270/Q2W094RM
More data for this
Ligand-Target Pair
BRAF-MEK-ERK


(Homo sapiens (human))
BDBM200411
PNG
(US9227969, 39)
Show SMILES Cc1nc2cnc3cc(F)c(cc3c2n1C1CCN(CC1)C(=O)CN)-c1ccc(Oc2ncccn2)cc1Cl
Show InChI InChI=1S/C28H25ClFN7O2/c1-16-35-25-15-34-24-13-23(30)20(19-4-3-18(11-22(19)29)39-28-32-7-2-8-33-28)12-21(24)27(25)37(16)17-5-9-36(10-6-17)26(38)14-31/h2-4,7-8,11-13,15,17H,5-6,9-10,14,31H2,1H3
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n/an/a 455n/an/an/an/a7.5n/a



NOVARTIS AG

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Assay Description
A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...


US Patent US9227969 (2016)


BindingDB Entry DOI: 10.7270/Q2W094RM
More data for this
Ligand-Target Pair
BRAF-MEK-ERK


(Homo sapiens (human))
BDBM200412
PNG
(US9227969, 40)
Show SMILES Cc1nc2cnc3cc(F)c(cc3c2n1C1CCN(CC1)C(=O)CN)-c1ccc(Oc2nccc(C)n2)cc1Cl
Show InChI InChI=1S/C29H27ClFN7O2/c1-16-5-8-33-29(35-16)40-19-3-4-20(23(30)11-19)21-12-22-25(13-24(21)31)34-15-26-28(22)38(17(2)36-26)18-6-9-37(10-7-18)27(39)14-32/h3-5,8,11-13,15,18H,6-7,9-10,14,32H2,1-2H3
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NOVARTIS AG

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Assay Description
A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...


US Patent US9227969 (2016)


BindingDB Entry DOI: 10.7270/Q2W094RM
More data for this
Ligand-Target Pair
BRAF-MEK-ERK


(Homo sapiens (human))
BDBM200413
PNG
(US9227969, 41)
Show SMILES Cc1ccnc(Oc2ccc(c(Cl)c2)-c2cc3c4n(cnc4cnc3cc2F)C2(CO)CCN(CC2)C(=O)CN)n1
Show InChI InChI=1S/C29H27ClFN7O3/c1-17-4-7-33-28(36-17)41-18-2-3-19(22(30)10-18)20-11-21-24(12-23(20)31)34-14-25-27(21)38(16-35-25)29(15-39)5-8-37(9-6-29)26(40)13-32/h2-4,7,10-12,14,16,39H,5-6,8-9,13,15,32H2,1H3
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NOVARTIS AG

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Assay Description
A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...


US Patent US9227969 (2016)


BindingDB Entry DOI: 10.7270/Q2W094RM
More data for this
Ligand-Target Pair
BRAF-MEK-ERK


(Homo sapiens (human))
BDBM200414
PNG
(US9227969, 42)
Show SMILES COCC(=O)N1CCC(CC1)n1c(C)nc2cnc3cc(F)c(cc3c12)-c1ccc(Oc2ncccn2)cc1Cl
Show InChI InChI=1S/C29H26ClFN6O3/c1-17-35-26-15-34-25-14-24(31)21(20-5-4-19(12-23(20)30)40-29-32-8-3-9-33-29)13-22(25)28(26)37(17)18-6-10-36(11-7-18)27(38)16-39-2/h3-5,8-9,12-15,18H,6-7,10-11,16H2,1-2H3
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NOVARTIS AG

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Assay Description
A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...


US Patent US9227969 (2016)


BindingDB Entry DOI: 10.7270/Q2W094RM
More data for this
Ligand-Target Pair
BRAF-MEK-ERK


(Homo sapiens (human))
BDBM200415
PNG
(US9227969, 43A | US9227969, 43B)
Show SMILES CC(F)C(=O)N1CCC(CC1)n1c(C)nc2cnc3cc(F)c(cc3c12)-c1ccc(Oc2ncccn2)cc1Cl
Show InChI InChI=1S/C29H25ClF2N6O2/c1-16(31)28(39)37-10-6-18(7-11-37)38-17(2)36-26-15-35-25-14-24(32)21(13-22(25)27(26)38)20-5-4-19(12-23(20)30)40-29-33-8-3-9-34-29/h3-5,8-9,12-16,18H,6-7,10-11H2,1-2H3
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NOVARTIS AG

US Patent


Assay Description
A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...


US Patent US9227969 (2016)


BindingDB Entry DOI: 10.7270/Q2W094RM
More data for this
Ligand-Target Pair
BRAF-MEK-ERK


(Homo sapiens (human))
BDBM200415
PNG
(US9227969, 43A | US9227969, 43B)
Show SMILES CC(F)C(=O)N1CCC(CC1)n1c(C)nc2cnc3cc(F)c(cc3c12)-c1ccc(Oc2ncccn2)cc1Cl
Show InChI InChI=1S/C29H25ClF2N6O2/c1-16(31)28(39)37-10-6-18(7-11-37)38-17(2)36-26-15-35-25-14-24(32)21(13-22(25)27(26)38)20-5-4-19(12-23(20)30)40-29-33-8-3-9-34-29/h3-5,8-9,12-16,18H,6-7,10-11H2,1-2H3
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NOVARTIS AG

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Assay Description
A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...


US Patent US9227969 (2016)


BindingDB Entry DOI: 10.7270/Q2W094RM
More data for this
Ligand-Target Pair
BRAF-MEK-ERK


(Homo sapiens (human))
BDBM200417
PNG
(US9227969, 44)
Show SMILES Cc1nc2cnc3cc(F)c(cc3c2n1C1CCN(CC1)C(=O)CO)-c1ccc(Oc2cccc(CO)n2)cc1Cl
Show InChI InChI=1S/C30H27ClFN5O4/c1-17-34-27-14-33-26-13-25(32)22(12-23(26)30(27)37(17)19-7-9-36(10-8-19)29(40)16-39)21-6-5-20(11-24(21)31)41-28-4-2-3-18(15-38)35-28/h2-6,11-14,19,38-39H,7-10,15-16H2,1H3
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NOVARTIS AG

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Assay Description
A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...


US Patent US9227969 (2016)


BindingDB Entry DOI: 10.7270/Q2W094RM
More data for this
Ligand-Target Pair
BRAF-MEK-ERK


(Homo sapiens (human))
BDBM200418
PNG
(US9227969, 45)
Show SMILES Cc1nc2cnc3cc(F)c(cc3c2n1C1CCN(CC1)C(=O)NCC(F)(F)F)-c1ccc(Oc2ncccn2)cc1Cl
Show InChI InChI=1S/C29H24ClF4N7O2/c1-16-39-25-14-37-24-13-23(31)20(19-4-3-18(11-22(19)30)43-27-35-7-2-8-36-27)12-21(24)26(25)41(16)17-5-9-40(10-6-17)28(42)38-15-29(32,33)34/h2-4,7-8,11-14,17H,5-6,9-10,15H2,1H3,(H,38,42)
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NOVARTIS AG

US Patent


Assay Description
A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...


US Patent US9227969 (2016)


BindingDB Entry DOI: 10.7270/Q2W094RM
More data for this
Ligand-Target Pair
BRAF-MEK-ERK


(Homo sapiens (human))
BDBM200419
PNG
(US9227969, 46)
Show SMILES Cc1nc2cnc3cc(F)c(cc3c2n1C1CCN(CC1)C(=O)CO)-c1ccc(Oc2nccc(F)n2)cc1Cl
Show InChI InChI=1S/C28H23ClF2N6O3/c1-15-34-24-13-33-23-12-22(30)19(18-3-2-17(10-21(18)29)40-28-32-7-4-25(31)35-28)11-20(23)27(24)37(15)16-5-8-36(9-6-16)26(39)14-38/h2-4,7,10-13,16,38H,5-6,8-9,14H2,1H3
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NOVARTIS AG

US Patent


Assay Description
A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...


US Patent US9227969 (2016)


BindingDB Entry DOI: 10.7270/Q2W094RM
More data for this
Ligand-Target Pair
BRAF-MEK-ERK


(Homo sapiens (human))
BDBM200420
PNG
(US9227969, 47)
Show SMILES Cc1nc2cnc3cc(F)c(cc3c2n1C1CCN(CC1)C(=O)CO)-c1ccc(Oc2cccc(F)n2)cc1Cl
Show InChI InChI=1S/C29H24ClF2N5O3/c1-16-34-25-14-33-24-13-23(31)20(19-6-5-18(11-22(19)30)40-27-4-2-3-26(32)35-27)12-21(24)29(25)37(16)17-7-9-36(10-8-17)28(39)15-38/h2-6,11-14,17,38H,7-10,15H2,1H3
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NOVARTIS AG

US Patent


Assay Description
A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...


US Patent US9227969 (2016)


BindingDB Entry DOI: 10.7270/Q2W094RM
More data for this
Ligand-Target Pair
BRAF-MEK-ERK


(Homo sapiens (human))
BDBM200421
PNG
(US9227969, 48)
Show SMILES Cc1nc2cnc3cc(F)c(cc3c2n1C1CCN(CC1)C(=O)CO)-c1ccc(Oc2ncc(F)c(C)n2)cc1Cl
Show InChI InChI=1S/C29H25ClF2N6O3/c1-15-24(32)12-34-29(35-15)41-18-3-4-19(22(30)9-18)20-10-21-25(11-23(20)31)33-13-26-28(21)38(16(2)36-26)17-5-7-37(8-6-17)27(40)14-39/h3-4,9-13,17,39H,5-8,14H2,1-2H3
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NOVARTIS AG

US Patent


Assay Description
A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...


US Patent US9227969 (2016)


BindingDB Entry DOI: 10.7270/Q2W094RM
More data for this
Ligand-Target Pair
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