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Compile Data Set for Download or QSAR

Found 2504 hits Enz. Inhib. hit(s) with Target = 'Basic fibroblast growth factor'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM6619
PNG
(3-[(9bR)-5-oxo-1H,2H,3H,5H,9bH-benzo[a]pyrrolizin-...)
Show SMILES O=C(Nc1ccccn1)Nc1cccc2C(=O)N3CCC[C@@H]3c12
Show InChI InChI=1S/C17H16N4O2/c22-16-11-5-3-6-12(15(11)13-7-4-10-21(13)16)19-17(23)20-14-8-1-2-9-18-14/h1-3,5-6,8-9,13H,4,7,10H2,(H2,18,19,20,23)/t13-/m1/s1
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PubMed
n/an/a 6.70E+3n/an/an/an/a7.022



Banyu Tsukuba Research Institute



Assay Description
Src, Lck, Flt-1, ZAP, EGFR, FGFR1, and PFGFR-beta were assayed in the Merck research laboratory (Homogeneous proximity tyrosine kinase assays: scinti...


J Med Chem 44: 4628-40 (2001)


Article DOI: 10.1021/jm010326y
BindingDB Entry DOI: 10.7270/Q2BV7DS8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM4168
PNG
(1,6-naphthyridin-2(1H)-one deriv. 7a | 7-Amino-3-(...)
Show SMILES Cn1c2cc(N)ncc2cc(-c2c(Cl)cccc2Cl)c1=O
Show InChI InChI=1S/C15H11Cl2N3O/c1-20-12-6-13(18)19-7-8(12)5-9(15(20)21)14-10(16)3-2-4-11(14)17/h2-7H,1H3,(H2,18,19)
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PubMed
n/an/a 380n/an/an/an/a7.025



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 43: 3134-47 (2000)


Article DOI: 10.1021/jm000148t
BindingDB Entry DOI: 10.7270/Q2028PQ1
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM4169
PNG
(1,6-naphthyridin-2(1H)-one deriv. 7b | 3-(2,6-Dich...)
Show SMILES CNc1cc2n(C)c(=O)c(cc2cn1)-c1c(Cl)cccc1Cl
Show InChI InChI=1S/C16H13Cl2N3O/c1-19-14-7-13-9(8-20-14)6-10(16(22)21(13)2)15-11(17)4-3-5-12(15)18/h3-8H,1-2H3,(H,19,20)
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PubMed
n/an/a 210n/an/an/an/a7.025



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 43: 3134-47 (2000)


Article DOI: 10.1021/jm000148t
BindingDB Entry DOI: 10.7270/Q2028PQ1
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM4174
PNG
(1,6-naphthyridin-2(1H)-one deriv. 7g | 3-(2,6-Dich...)
Show SMILES CCN(CC)CCCCCNc1cc2n(C)c(=O)c(cc2cn1)-c1c(Cl)cccc1Cl
Show InChI InChI=1S/C24H30Cl2N4O/c1-4-30(5-2)13-8-6-7-12-27-22-15-21-17(16-28-22)14-18(24(31)29(21)3)23-19(25)10-9-11-20(23)26/h9-11,14-16H,4-8,12-13H2,1-3H3,(H,27,28)
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PubMed
n/an/a 80n/an/an/an/a7.025



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 43: 3134-47 (2000)


Article DOI: 10.1021/jm000148t
BindingDB Entry DOI: 10.7270/Q2028PQ1
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM4171
PNG
(1,6-naphthyridin-2(1H)-one deriv. 7d | 3-(2,6-Dich...)
Show SMILES CCN(CC)CCNc1cc2n(C)c(=O)c(cc2cn1)-c1c(Cl)cccc1Cl
Show InChI InChI=1S/C21H24Cl2N4O/c1-4-27(5-2)10-9-24-19-12-18-14(13-25-19)11-15(21(28)26(18)3)20-16(22)7-6-8-17(20)23/h6-8,11-13H,4-5,9-10H2,1-3H3,(H,24,25)
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PubMed
n/an/a 3.30E+4n/an/an/an/a7.025



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 43: 3134-47 (2000)


Article DOI: 10.1021/jm000148t
BindingDB Entry DOI: 10.7270/Q2028PQ1
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM4172
PNG
(1,6-naphthyridin-2(1H)-one deriv. 7e | 3-(2,6-Dich...)
Show SMILES CCN(CC)CCCNc1cc2n(C)c(=O)c(cc2cn1)-c1c(Cl)cccc1Cl
Show InChI InChI=1S/C22H26Cl2N4O/c1-4-28(5-2)11-7-10-25-20-13-19-15(14-26-20)12-16(22(29)27(19)3)21-17(23)8-6-9-18(21)24/h6,8-9,12-14H,4-5,7,10-11H2,1-3H3,(H,25,26)
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PubMed
n/an/a 150n/an/an/an/a7.025



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 43: 3134-47 (2000)


Article DOI: 10.1021/jm000148t
BindingDB Entry DOI: 10.7270/Q2028PQ1
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM4173
PNG
(1,6-naphthyridin-2(1H)-one deriv. 7f | 3-(2,6-Dich...)
Show SMILES CCN(CC)CCCCNc1cc2n(C)c(=O)c(cc2cn1)-c1c(Cl)cccc1Cl
Show InChI InChI=1S/C23H28Cl2N4O/c1-4-29(5-2)12-7-6-11-26-21-14-20-16(15-27-21)13-17(23(30)28(20)3)22-18(24)9-8-10-19(22)25/h8-10,13-15H,4-7,11-12H2,1-3H3,(H,26,27)
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PubMed
n/an/a 80n/an/an/an/a7.025



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 43: 3134-47 (2000)


Article DOI: 10.1021/jm000148t
BindingDB Entry DOI: 10.7270/Q2028PQ1
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM4170
PNG
(1,6-naphthyridin-2(1H)-one deriv. 7c | 3-(2,6-Dich...)
Show SMILES CN(C)c1cc2n(C)c(=O)c(cc2cn1)-c1c(Cl)cccc1Cl
Show InChI InChI=1S/C17H15Cl2N3O/c1-21(2)15-8-14-10(9-20-15)7-11(17(23)22(14)3)16-12(18)5-4-6-13(16)19/h4-9H,1-3H3
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n/an/a>5.00E+4n/an/an/an/a7.025



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 43: 3134-47 (2000)


Article DOI: 10.1021/jm000148t
BindingDB Entry DOI: 10.7270/Q2028PQ1
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM4618
PNG
(1,6-naphthyridine 14 | 1,6-naphthyridine deriv. 20...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCN3CCOCC3)cc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C28H38N6O4/c1-28(2,3)33-27(35)32-26-23(19-13-21(36-4)16-22(14-19)37-5)15-20-18-30-25(17-24(20)31-26)29-7-6-8-34-9-11-38-12-10-34/h13-18H,6-12H2,1-5H3,(H,29,30)(H2,31,32,33,35)
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PubMed
n/an/a 31n/an/an/an/a7.425



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
BindingDB Entry DOI: 10.7270/Q2DV1H3W
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM6146
PNG
(1,6-naphthyridine 15 | 3-(3,5-Dimethoxyphenyl)-N7-...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCN3CCN(C)CC3)cc2nc1N
Show InChI InChI=1S/C24H32N6O2/c1-29-7-9-30(10-8-29)6-4-5-26-23-15-22-18(16-27-23)13-21(24(25)28-22)17-11-19(31-2)14-20(12-17)32-3/h11-16H,4-10H2,1-3H3,(H2,25,28)(H,26,27)
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n/an/a 44n/an/an/an/a7.425



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
BindingDB Entry DOI: 10.7270/Q2DV1H3W
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM6147
PNG
(1,6-naphthyridine 16 | 1-[3-(3,5-dimethoxyphenyl)-...)
Show SMILES CCNC(=O)Nc1nc2cc(NCCCN3CCN(C)CC3)ncc2cc1-c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C27H37N7O3/c1-5-28-27(35)32-26-23(19-13-21(36-3)16-22(14-19)37-4)15-20-18-30-25(17-24(20)31-26)29-7-6-8-34-11-9-33(2)10-12-34/h13-18H,5-12H2,1-4H3,(H,29,30)(H2,28,31,32,35)
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n/an/a 21n/an/an/an/a7.425



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
BindingDB Entry DOI: 10.7270/Q2DV1H3W
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM6148
PNG
(1,6-naphthyridine 17 | 3-tert-butyl-1-[3-(3,5-dime...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCN3CCN(C)CC3)cc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C29H41N7O3/c1-29(2,3)34-28(37)33-27-24(20-14-22(38-5)17-23(15-20)39-6)16-21-19-31-26(18-25(21)32-27)30-8-7-9-36-12-10-35(4)11-13-36/h14-19H,7-13H2,1-6H3,(H,30,31)(H2,32,33,34,37)
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n/an/a 24n/an/an/an/a7.425



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
BindingDB Entry DOI: 10.7270/Q2DV1H3W
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM6149
PNG
(1,6-naphthyridine 18 | 3-tert-butyl-1-(7-{[3-(diet...)
Show SMILES CCN(CC)CCCNc1cc2nc(NC(=O)NC(C)(C)C)c(cc2cn1)-c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C28H40N6O3/c1-8-34(9-2)12-10-11-29-25-17-24-20(18-30-25)15-23(19-13-21(36-6)16-22(14-19)37-7)26(31-24)32-27(35)33-28(3,4)5/h13-18H,8-12H2,1-7H3,(H,29,30)(H2,31,32,33,35)
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n/an/a 60n/an/an/an/a7.425



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)


Article DOI: 10.1021/jm0500931
BindingDB Entry DOI: 10.7270/Q2DV1H3W
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM84561
PNG
(Linked sulfated tetracyclitol, 2)
Show SMILES [O-]S(=O)(=O)O[C@@H]1C=C[C@@H]([C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)N(CCN([C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)[C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)[C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O
Show InChI InChI=1S/C26H40N2O48S12/c29-77(30,31)65-15-5-1-11(19(69-81(41,42)43)23(15)73-85(53,54)55)27(12-2-6-16(66-78(32,33)34)24(74-86(56,57)58)20(12)70-82(44,45)46)9-10-28(13-3-7-17(67-79(35,36)37)25(75-87(59,60)61)21(13)71-83(47,48)49)14-4-8-18(68-80(38,39)40)26(76-88(62,63)64)22(14)72-84(50,51)52/h1-8,11-26H,9-10H2,(H,29,30,31)(H,32,33,34)(H,35,36,37)(H,38,39,40)(H,41,42,43)(H,44,45,46)(H,47,48,49)(H,50,51,52)(H,53,54,55)(H,56,57,58)(H,59,60,61)(H,62,63,64)/p-12/t11-,12-,13-,14-,15+,16+,17+,18+,19+,20+,21+,22+,23+,24+,25+,26+/m0/s1
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n/an/an/a 1.10E+3n/an/an/a7.4n/a



Progen Industries Ltd.



Assay Description
Human FGF-1 and FGF-2 were purchased from R&D Systems, Inc. and supplied as protein (ug) dissolved in bovine serum albumin (BSA, 50ug). Surface plas...


Chembiochem 6: 1882-90 (2005)

Checked by Author
Article DOI: 10.1002/cbic.200500089
BindingDB Entry DOI: 10.7270/Q22N50S0
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM84562
PNG
(Linked sulfated tetracyclitol, 3)
Show SMILES [O-]S(=O)(=O)O[C@@H]1C=C[C@@H]([C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)N(CCCN([C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)[C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)[C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O
Show InChI InChI=1S/C27H42N2O48S12/c30-78(31,32)66-16-6-2-12(20(70-82(42,43)44)24(16)74-86(54,55)56)28(13-3-7-17(67-79(33,34)35)25(75-87(57,58)59)21(13)71-83(45,46)47)10-1-11-29(14-4-8-18(68-80(36,37)38)26(76-88(60,61)62)22(14)72-84(48,49)50)15-5-9-19(69-81(39,40)41)27(77-89(63,64)65)23(15)73-85(51,52)53/h2-9,12-27H,1,10-11H2,(H,30,31,32)(H,33,34,35)(H,36,37,38)(H,39,40,41)(H,42,43,44)(H,45,46,47)(H,48,49,50)(H,51,52,53)(H,54,55,56)(H,57,58,59)(H,60,61,62)(H,63,64,65)/p-12/t12-,13-,14-,15-,16+,17+,18+,19+,20+,21+,22+,23+,24+,25+,26+,27+/m0/s1
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n/an/an/a 248n/an/an/a7.4n/a



Progen Industries Ltd.



Assay Description
Human FGF-1 and FGF-2 were purchased from R&D Systems, Inc. and supplied as protein (ug) dissolved in bovine serum albumin (BSA, 50ug). Surface plas...


Chembiochem 6: 1882-90 (2005)

Checked by Author
Article DOI: 10.1002/cbic.200500089
BindingDB Entry DOI: 10.7270/Q22N50S0
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM84563
PNG
(Linked sulfated tetracyclitol, 4)
Show SMILES [O-]S(=O)(=O)O[C@@H]1C=C[C@@H]([C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)N(CCCCN([C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)[C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)[C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O
Show InChI InChI=1S/C28H44N2O48S12/c31-79(32,33)67-17-7-3-13(21(71-83(43,44)45)25(17)75-87(55,56)57)29(14-4-8-18(68-80(34,35)36)26(76-88(58,59)60)22(14)72-84(46,47)48)11-1-2-12-30(15-5-9-19(69-81(37,38)39)27(77-89(61,62)63)23(15)73-85(49,50)51)16-6-10-20(70-82(40,41)42)28(78-90(64,65)66)24(16)74-86(52,53)54/h3-10,13-28H,1-2,11-12H2,(H,31,32,33)(H,34,35,36)(H,37,38,39)(H,40,41,42)(H,43,44,45)(H,46,47,48)(H,49,50,51)(H,52,53,54)(H,55,56,57)(H,58,59,60)(H,61,62,63)(H,64,65,66)/p-12/t13-,14-,15-,16-,17+,18+,19+,20+,21+,22+,23+,24+,25+,26+,27+,28+/m0/s1
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n/an/an/a 161n/an/an/a7.4n/a



Progen Industries Ltd.



Assay Description
Human FGF-1 and FGF-2 were purchased from R&D Systems, Inc. and supplied as protein (ug) dissolved in bovine serum albumin (BSA, 50ug). Surface plas...


Chembiochem 6: 1882-90 (2005)

Checked by Author
Article DOI: 10.1002/cbic.200500089
BindingDB Entry DOI: 10.7270/Q22N50S0
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM84564
PNG
(Linked sulfated tetracyclitol, 5)
Show SMILES [O-]S(=O)(=O)O[C@@H]1C=C[C@@H]([C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)N(CCCCCN([C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)[C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)[C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O
Show InChI InChI=1S/C29H46N2O48S12/c32-80(33,34)68-18-8-4-14(22(72-84(44,45)46)26(18)76-88(56,57)58)30(15-5-9-19(69-81(35,36)37)27(77-89(59,60)61)23(15)73-85(47,48)49)12-2-1-3-13-31(16-6-10-20(70-82(38,39)40)28(78-90(62,63)64)24(16)74-86(50,51)52)17-7-11-21(71-83(41,42)43)29(79-91(65,66)67)25(17)75-87(53,54)55/h4-11,14-29H,1-3,12-13H2,(H,32,33,34)(H,35,36,37)(H,38,39,40)(H,41,42,43)(H,44,45,46)(H,47,48,49)(H,50,51,52)(H,53,54,55)(H,56,57,58)(H,59,60,61)(H,62,63,64)(H,65,66,67)/p-12/t14-,15-,16-,17-,18+,19+,20+,21+,22+,23+,24+,25+,26+,27+,28+,29+/m0/s1
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n/an/an/a 148n/an/an/a7.4n/a



Progen Industries Ltd.



Assay Description
Human FGF-1 and FGF-2 were purchased from R&D Systems, Inc. and supplied as protein (ug) dissolved in bovine serum albumin (BSA, 50ug). Surface plas...


Chembiochem 6: 1882-90 (2005)

Checked by Author
Article DOI: 10.1002/cbic.200500089
BindingDB Entry DOI: 10.7270/Q22N50S0
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM84565
PNG
(Linked sulfated tetracyclitol, 6)
Show SMILES [O-]S(=O)(=O)O[C@@H]1C=C[C@@H]([C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)N(CCCCCCN([C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)[C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)[C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O
Show InChI InChI=1S/C30H48N2O48S12/c33-81(34,35)69-19-9-5-15(23(73-85(45,46)47)27(19)77-89(57,58)59)31(16-6-10-20(70-82(36,37)38)28(78-90(60,61)62)24(16)74-86(48,49)50)13-3-1-2-4-14-32(17-7-11-21(71-83(39,40)41)29(79-91(63,64)65)25(17)75-87(51,52)53)18-8-12-22(72-84(42,43)44)30(80-92(66,67)68)26(18)76-88(54,55)56/h5-12,15-30H,1-4,13-14H2,(H,33,34,35)(H,36,37,38)(H,39,40,41)(H,42,43,44)(H,45,46,47)(H,48,49,50)(H,51,52,53)(H,54,55,56)(H,57,58,59)(H,60,61,62)(H,63,64,65)(H,66,67,68)/p-12/t15-,16-,17-,18-,19+,20+,21+,22+,23+,24+,25+,26+,27+,28+,29+,30+/m0/s1
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n/an/an/a 135n/an/an/a7.4n/a



Progen Industries Ltd.



Assay Description
Human FGF-1 and FGF-2 were purchased from R&D Systems, Inc. and supplied as protein (ug) dissolved in bovine serum albumin (BSA, 50ug). Surface plas...


Chembiochem 6: 1882-90 (2005)

Checked by Author
Article DOI: 10.1002/cbic.200500089
BindingDB Entry DOI: 10.7270/Q22N50S0
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM84566
PNG
(Linked sulfated tetracyclitol, 7)
Show SMILES [O-]S(=O)(=O)O[C@@H]1C=C[C@@H]([C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)N(CCCCCCCN([C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)[C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)[C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O
Show InChI InChI=1S/C31H50N2O48S12/c34-82(35,36)70-20-10-6-16(24(74-86(46,47)48)28(20)78-90(58,59)60)32(17-7-11-21(71-83(37,38)39)29(79-91(61,62)63)25(17)75-87(49,50)51)14-4-2-1-3-5-15-33(18-8-12-22(72-84(40,41)42)30(80-92(64,65)66)26(18)76-88(52,53)54)19-9-13-23(73-85(43,44)45)31(81-93(67,68)69)27(19)77-89(55,56)57/h6-13,16-31H,1-5,14-15H2,(H,34,35,36)(H,37,38,39)(H,40,41,42)(H,43,44,45)(H,46,47,48)(H,49,50,51)(H,52,53,54)(H,55,56,57)(H,58,59,60)(H,61,62,63)(H,64,65,66)(H,67,68,69)/p-12/t16-,17-,18-,19-,20+,21+,22+,23+,24+,25+,26+,27+,28+,29+,30+,31+/m0/s1
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n/an/an/a 90n/an/an/a7.4n/a



Progen Industries Ltd.



Assay Description
Human FGF-1 and FGF-2 were purchased from R&D Systems, Inc. and supplied as protein (ug) dissolved in bovine serum albumin (BSA, 50ug). Surface plas...


Chembiochem 6: 1882-90 (2005)

Checked by Author
Article DOI: 10.1002/cbic.200500089
BindingDB Entry DOI: 10.7270/Q22N50S0
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM84567
PNG
(Linked sulfated tetracyclitol, 8)
Show SMILES [O-]S(=O)(=O)O[C@@H]1C=C[C@@H]([C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)N(CCCCCCCCN([C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)[C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)[C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O
Show InChI InChI=1S/C32H52N2O48S12/c35-83(36,37)71-21-11-7-17(25(75-87(47,48)49)29(21)79-91(59,60)61)33(18-8-12-22(72-84(38,39)40)30(80-92(62,63)64)26(18)76-88(50,51)52)15-5-3-1-2-4-6-16-34(19-9-13-23(73-85(41,42)43)31(81-93(65,66)67)27(19)77-89(53,54)55)20-10-14-24(74-86(44,45)46)32(82-94(68,69)70)28(20)78-90(56,57)58/h7-14,17-32H,1-6,15-16H2,(H,35,36,37)(H,38,39,40)(H,41,42,43)(H,44,45,46)(H,47,48,49)(H,50,51,52)(H,53,54,55)(H,56,57,58)(H,59,60,61)(H,62,63,64)(H,65,66,67)(H,68,69,70)/p-12/t17-,18-,19-,20-,21+,22+,23+,24+,25+,26+,27+,28+,29+,30+,31+,32+/m0/s1
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n/an/an/a 108n/an/an/a7.4n/a



Progen Industries Ltd.



Assay Description
Human FGF-1 and FGF-2 were purchased from R&D Systems, Inc. and supplied as protein (ug) dissolved in bovine serum albumin (BSA, 50ug). Surface plas...


Chembiochem 6: 1882-90 (2005)

Checked by Author
Article DOI: 10.1002/cbic.200500089
BindingDB Entry DOI: 10.7270/Q22N50S0
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM84568
PNG
(Linked sulfated tetracyclitol, 9)
Show SMILES [O-]S(=O)(=O)O[C@@H]1C=C[C@@H]([C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)N(CCCCCCCCCN([C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)[C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)[C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O
Show InChI InChI=1S/C33H54N2O48S12/c36-84(37,38)72-22-12-8-18(26(76-88(48,49)50)30(22)80-92(60,61)62)34(19-9-13-23(73-85(39,40)41)31(81-93(63,64)65)27(19)77-89(51,52)53)16-6-4-2-1-3-5-7-17-35(20-10-14-24(74-86(42,43)44)32(82-94(66,67)68)28(20)78-90(54,55)56)21-11-15-25(75-87(45,46)47)33(83-95(69,70)71)29(21)79-91(57,58)59/h8-15,18-33H,1-7,16-17H2,(H,36,37,38)(H,39,40,41)(H,42,43,44)(H,45,46,47)(H,48,49,50)(H,51,52,53)(H,54,55,56)(H,57,58,59)(H,60,61,62)(H,63,64,65)(H,66,67,68)(H,69,70,71)/p-12/t18-,19-,20-,21-,22+,23+,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+/m0/s1
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n/an/an/a 194n/an/an/a7.4n/a



Progen Industries Ltd.



Assay Description
Human FGF-1 and FGF-2 were purchased from R&D Systems, Inc. and supplied as protein (ug) dissolved in bovine serum albumin (BSA, 50ug). Surface plas...


Chembiochem 6: 1882-90 (2005)

Checked by Author
Article DOI: 10.1002/cbic.200500089
BindingDB Entry DOI: 10.7270/Q22N50S0
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM84569
PNG
(Linked sulfated tetracyclitol, 10)
Show SMILES [O-]S(=O)(=O)O[C@@H]1C=C[C@@H]([C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)N(CCCCCCCCCCN([C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)[C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)[C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O
Show InChI InChI=1S/C34H56N2O48S12/c37-85(38,39)73-23-13-9-19(27(77-89(49,50)51)31(23)81-93(61,62)63)35(20-10-14-24(74-86(40,41)42)32(82-94(64,65)66)28(20)78-90(52,53)54)17-7-5-3-1-2-4-6-8-18-36(21-11-15-25(75-87(43,44)45)33(83-95(67,68)69)29(21)79-91(55,56)57)22-12-16-26(76-88(46,47)48)34(84-96(70,71)72)30(22)80-92(58,59)60/h9-16,19-34H,1-8,17-18H2,(H,37,38,39)(H,40,41,42)(H,43,44,45)(H,46,47,48)(H,49,50,51)(H,52,53,54)(H,55,56,57)(H,58,59,60)(H,61,62,63)(H,64,65,66)(H,67,68,69)(H,70,71,72)/p-12/t19-,20-,21-,22-,23+,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34+/m0/s1
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n/an/an/a 448n/an/an/a7.4n/a



Progen Industries Ltd.



Assay Description
Human FGF-1 and FGF-2 were purchased from R&D Systems, Inc. and supplied as protein (ug) dissolved in bovine serum albumin (BSA, 50ug). Surface plas...


Chembiochem 6: 1882-90 (2005)

Checked by Author
Article DOI: 10.1002/cbic.200500089
BindingDB Entry DOI: 10.7270/Q22N50S0
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM84570
PNG
(Linked sulfated tetracyclitol, 11)
Show SMILES [O-]S(=O)(=O)O[C@@H]1C=C[C@@H]([C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)N([C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)c1ccc(cc1)N([C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)[C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O
Show InChI InChI=1S/C30H40N2O48S12/c33-81(34,35)69-19-9-5-15(23(73-85(45,46)47)27(19)77-89(57,58)59)31(16-6-10-20(70-82(36,37)38)28(78-90(60,61)62)24(16)74-86(48,49)50)13-1-2-14(4-3-13)32(17-7-11-21(71-83(39,40)41)29(79-91(63,64)65)25(17)75-87(51,52)53)18-8-12-22(72-84(42,43)44)30(80-92(66,67)68)26(18)76-88(54,55)56/h1-12,15-30H,(H,33,34,35)(H,36,37,38)(H,39,40,41)(H,42,43,44)(H,45,46,47)(H,48,49,50)(H,51,52,53)(H,54,55,56)(H,57,58,59)(H,60,61,62)(H,63,64,65)(H,66,67,68)/p-12/t15-,16-,17-,18-,19+,20+,21+,22+,23+,24+,25+,26+,27+,28+,29+,30+/m0/s1
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n/an/an/a 332n/an/an/a7.4n/a



Progen Industries Ltd.



Assay Description
Human FGF-1 and FGF-2 were purchased from R&D Systems, Inc. and supplied as protein (ug) dissolved in bovine serum albumin (BSA, 50ug). Surface plas...


Chembiochem 6: 1882-90 (2005)

Checked by Author
Article DOI: 10.1002/cbic.200500089
BindingDB Entry DOI: 10.7270/Q22N50S0
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM84571
PNG
(Linked sulfated tetracyclitol, 12)
Show SMILES [O-]S(=O)(=O)O[C@@H]1C=CC([C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)N(CN([C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)[C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)CN([C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)[C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O
Show InChI InChI=1S/C32H51N3O60S15/c36-96(37,38)81-18-6-1-13(23(86-101(51,52)53)28(18)91-106(66,67)68)33(11-34(14-2-7-19(82-97(39,40)41)29(92-107(69,70)71)24(14)87-102(54,55)56)15-3-8-20(83-98(42,43)44)30(93-108(72,73)74)25(15)88-103(57,58)59)12-35(16-4-9-21(84-99(45,46)47)31(94-109(75,76)77)26(16)89-104(60,61)62)17-5-10-22(85-100(48,49)50)32(95-110(78,79)80)27(17)90-105(63,64)65/h1-10,13-32,102H,11-12H2,(H,36,37,38)(H,39,40,41)(H,42,43,44)(H,45,46,47)(H,48,49,50)(H,51,52,53)(H2,54,55,56)(H,57,58,59)(H,60,61,62)(H,63,64,65)(H,66,67,68)(H,69,70,71)(H,72,73,74)(H,75,76,77)(H,78,79,80)/p-15/t13?,14-,15-,16-,17-,18+,19+,20+,21+,22+,23+,24+,25+,26+,27+,28+,29+,30+,31+,32+/m0/s1
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n/an/an/a 85n/an/an/a7.4n/a



Progen Industries Ltd.



Assay Description
Human FGF-1 and FGF-2 were purchased from R&D Systems, Inc. and supplied as protein (ug) dissolved in bovine serum albumin (BSA, 50ug). Surface plas...


Chembiochem 6: 1882-90 (2005)

Checked by Author
Article DOI: 10.1002/cbic.200500089
BindingDB Entry DOI: 10.7270/Q22N50S0
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM3050
PNG
(2-Amino-6-(2,6-dichlorophenyl)-8-methylpyrido[2,3-...)
Show SMILES Cn1c2nc(N)ncc2cc(-c2c(Cl)cccc2Cl)c1=O
Show InChI InChI=1S/C14H10Cl2N4O/c1-20-12-7(6-18-14(17)19-12)5-8(13(20)21)11-9(15)3-2-4-10(11)16/h2-6H,1H3,(H2,17,18,19)
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n/an/a 1.30E+3n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 3276-92 (1998)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q27P8WK3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM3051
PNG
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 5 | N-[6-(...)
Show SMILES CC(=O)Nc1ncc2cc(-c3c(Cl)cccc3Cl)c(=O)n(C)c2n1
Show InChI InChI=1S/C16H12Cl2N4O2/c1-8(23)20-16-19-7-9-6-10(15(24)22(2)14(9)21-16)13-11(17)4-3-5-12(13)18/h3-7H,1-2H3,(H,19,20,21,23)
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n/an/a 5.80E+3n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 3276-92 (1998)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q27P8WK3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM3052
PNG
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 19 | 6-(2,...)
Show SMILES Cc1ncc2cc(-c3c(Cl)cccc3Cl)c(=O)n(C)c2n1
Show InChI InChI=1S/C15H11Cl2N3O/c1-8-18-7-9-6-10(15(21)20(2)14(9)19-8)13-11(16)4-3-5-12(13)17/h3-7H,1-2H3
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n/an/a>5.00E+4n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 3276-92 (1998)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q27P8WK3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM3053
PNG
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 20 | 6-(2,...)
Show SMILES Cn1c2nc(=O)[nH]cc2cc(-c2c(Cl)cccc2Cl)c1=O
Show InChI InChI=1S/C14H9Cl2N3O2/c1-19-12-7(6-17-14(21)18-12)5-8(13(19)20)11-9(15)3-2-4-10(11)16/h2-6H,1H3,(H,17,18,21)
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n/an/a>5.00E+4n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 3276-92 (1998)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q27P8WK3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM3054
PNG
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 21 | 6-(2,...)
Show SMILES CNc1ncc2cc(-c3c(Cl)cccc3Cl)c(=O)n(C)c2n1
Show InChI InChI=1S/C15H12Cl2N4O/c1-18-15-19-7-8-6-9(14(22)21(2)13(8)20-15)12-10(16)4-3-5-11(12)17/h3-7H,1-2H3,(H,18,19,20)
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n/an/a 2.50E+3n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 3276-92 (1998)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q27P8WK3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM3055
PNG
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 22 | 6-(2,...)
Show SMILES CCNc1ncc2cc(-c3c(Cl)cccc3Cl)c(=O)n(C)c2n1
Show InChI InChI=1S/C16H14Cl2N4O/c1-3-19-16-20-8-9-7-10(15(23)22(2)14(9)21-16)13-11(17)5-4-6-12(13)18/h4-8H,3H2,1-2H3,(H,19,20,21)
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n/an/a 960n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 3276-92 (1998)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q27P8WK3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM3428
PNG
(1-[2-amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyri...)
Show SMILES CC(C)(C)NC(=O)Nc1nc2nc(N)ncc2cc1-c1c(Cl)cccc1Cl
Show InChI InChI=1S/C18H18Cl2N6O/c1-18(2,3)26-17(27)25-15-10(13-11(19)5-4-6-12(13)20)7-9-8-22-16(21)24-14(9)23-15/h4-8H,1-3H3,(H4,21,22,23,24,25,26,27)
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n/an/a 140n/an/an/an/a7.425



Pfizer



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 44: 1915-26 (2001)


Article DOI: 10.1021/jm0004291
BindingDB Entry DOI: 10.7270/Q29K48DG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM3429
PNG
(6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidine-2,7-...)
Show SMILES Nc1ncc2cc(c(N)nc2n1)-c1c(Cl)cccc1Cl
Show InChI InChI=1S/C13H9Cl2N5/c14-8-2-1-3-9(15)10(8)7-4-6-5-18-13(17)20-12(6)19-11(7)16/h1-5H,(H4,16,17,18,19,20)
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n/an/a 3.00E+3n/an/an/an/a7.425



Pfizer



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 44: 1915-26 (2001)


Article DOI: 10.1021/jm0004291
BindingDB Entry DOI: 10.7270/Q29K48DG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM3430
PNG
(6-(2,6-dichlorophenyl)-2-N-[3-(diethylamino)propyl...)
Show SMILES CCN(CC)CCCNc1ncc2cc(c(N)nc2n1)-c1c(Cl)cccc1Cl
Show InChI InChI=1S/C20H24Cl2N6/c1-3-28(4-2)10-6-9-24-20-25-12-13-11-14(18(23)26-19(13)27-20)17-15(21)7-5-8-16(17)22/h5,7-8,11-12H,3-4,6,9-10H2,1-2H3,(H3,23,24,25,26,27)
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n/an/a 2.40E+3n/an/an/an/a7.425



Pfizer



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 44: 1915-26 (2001)


Article DOI: 10.1021/jm0004291
BindingDB Entry DOI: 10.7270/Q29K48DG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM3431
PNG
(3-tert-butyl-1-[6-(2,6-dichlorophenyl)-2-{[3-(diet...)
Show SMILES CCN(CC)CCCNc1ncc2cc(c(NC(=O)NC(C)(C)C)nc2n1)-c1c(Cl)cccc1Cl
Show InChI InChI=1S/C25H33Cl2N7O/c1-6-34(7-2)13-9-12-28-23-29-15-16-14-17(20-18(26)10-8-11-19(20)27)22(30-21(16)31-23)32-24(35)33-25(3,4)5/h8,10-11,14-15H,6-7,9,12-13H2,1-5H3,(H3,28,29,30,31,32,33,35)
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n/an/a 82n/an/an/an/a7.425



Pfizer



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 44: 1915-26 (2001)


Article DOI: 10.1021/jm0004291
BindingDB Entry DOI: 10.7270/Q29K48DG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM3432
PNG
(6-(2,6-dimethylphenyl)pyrido[2,3-d]pyrimidine-2,7-...)
Show SMILES Cc1cccc(C)c1-c1cc2cnc(N)nc2nc1N
Show InChI InChI=1S/C15H15N5/c1-8-4-3-5-9(2)12(8)11-6-10-7-18-15(17)20-14(10)19-13(11)16/h3-7H,1-2H3,(H4,16,17,18,19,20)
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n/an/a 1.30E+4n/an/an/an/a7.425



Pfizer



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 44: 1915-26 (2001)


Article DOI: 10.1021/jm0004291
BindingDB Entry DOI: 10.7270/Q29K48DG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM3433
PNG
(1-[2-amino-6-(2,6-dimethylphenyl)pyrido[2,3-d]pyri...)
Show SMILES Cc1cccc(C)c1-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C20H24N6O/c1-11-7-6-8-12(2)15(11)14-9-13-10-22-18(21)24-16(13)23-17(14)25-19(27)26-20(3,4)5/h6-10H,1-5H3,(H4,21,22,23,24,25,26,27)
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n/an/a 400n/an/an/an/a7.425



Pfizer



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 44: 1915-26 (2001)


Article DOI: 10.1021/jm0004291
BindingDB Entry DOI: 10.7270/Q29K48DG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM3434
PNG
(2-N-[3-(diethylamino)propyl]-6-(2,6-dimethylphenyl...)
Show SMILES CCN(CC)CCCNc1ncc2cc(c(N)nc2n1)-c1c(C)cccc1C
Show InChI InChI=1S/C22H30N6/c1-5-28(6-2)12-8-11-24-22-25-14-17-13-18(20(23)26-21(17)27-22)19-15(3)9-7-10-16(19)4/h7,9-10,13-14H,5-6,8,11-12H2,1-4H3,(H3,23,24,25,26,27)
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n/an/a 1.80E+4n/an/an/an/a7.425



Pfizer



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 44: 1915-26 (2001)


Article DOI: 10.1021/jm0004291
BindingDB Entry DOI: 10.7270/Q29K48DG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM3050
PNG
(2-Amino-6-(2,6-dichlorophenyl)-8-methylpyrido[2,3-...)
Show SMILES Cn1c2nc(N)ncc2cc(-c2c(Cl)cccc2Cl)c1=O
Show InChI InChI=1S/C14H10Cl2N4O/c1-20-12-7(6-18-14(17)19-12)5-8(13(20)21)11-9(15)3-2-4-10(11)16/h2-6H,1H3,(H2,17,18,19)
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n/an/a 1.30E+3n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
BindingDB Entry DOI: 10.7270/Q2CC0XWN
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM4050
PNG
(2-Amino-6-(2,6-dichlorophenyl)-8-ethyl-8H-pyrido[2...)
Show SMILES CCn1c2nc(N)ncc2cc(-c2c(Cl)cccc2Cl)c1=O
Show InChI InChI=1S/C15H12Cl2N4O/c1-2-21-13-8(7-19-15(18)20-13)6-9(14(21)22)12-10(16)4-3-5-11(12)17/h3-7H,2H2,1H3,(H2,18,19,20)
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n/an/a 540n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
BindingDB Entry DOI: 10.7270/Q2CC0XWN
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM4051
PNG
(2-Amino-6-(2,6-dichlorophenyl)-8-propyl-8H-pyrido-...)
Show SMILES CCCn1c2nc(N)ncc2cc(-c2c(Cl)cccc2Cl)c1=O
Show InChI InChI=1S/C16H14Cl2N4O/c1-2-6-22-14-9(8-20-16(19)21-14)7-10(15(22)23)13-11(17)4-3-5-12(13)18/h3-5,7-8H,2,6H2,1H3,(H2,19,20,21)
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n/an/a 510n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
BindingDB Entry DOI: 10.7270/Q2CC0XWN
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM4052
PNG
(2-Amino-8-butyl-6-(2,6-dichlorophenyl)-8H-pyrido[2...)
Show SMILES CCCCn1c2nc(N)ncc2cc(-c2c(Cl)cccc2Cl)c1=O
Show InChI InChI=1S/C17H16Cl2N4O/c1-2-3-7-23-15-10(9-21-17(20)22-15)8-11(16(23)24)14-12(18)5-4-6-13(14)19/h4-6,8-9H,2-3,7H2,1H3,(H2,20,21,22)
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n/an/a 580n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
BindingDB Entry DOI: 10.7270/Q2CC0XWN
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM4053
PNG
(2-Amino-6-(2,6-dichlorophenyl)-8-isobutyl-8H-pyrid...)
Show SMILES CC(C)Cn1c2nc(N)ncc2cc(-c2c(Cl)cccc2Cl)c1=O
Show InChI InChI=1S/C17H16Cl2N4O/c1-9(2)8-23-15-10(7-21-17(20)22-15)6-11(16(23)24)14-12(18)4-3-5-13(14)19/h3-7,9H,8H2,1-2H3,(H2,20,21,22)
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n/an/a 500n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
BindingDB Entry DOI: 10.7270/Q2CC0XWN
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM4054
PNG
(2-Amino-6-(2,6-dichlorophenyl)-7-oxo-7H-pyrido[2,3...)
Show SMILES COC(=O)Cn1c2nc(N)ncc2cc(-c2c(Cl)cccc2Cl)c1=O
Show InChI InChI=1S/C16H12Cl2N4O3/c1-25-12(23)7-22-14-8(6-20-16(19)21-14)5-9(15(22)24)13-10(17)3-2-4-11(13)18/h2-6H,7H2,1H3,(H2,19,20,21)
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n/an/a 1.70E+3n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
BindingDB Entry DOI: 10.7270/Q2CC0XWN
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM4055
PNG
([2-Amino-6-(2,6-dichlorophenyl)-7-oxo-7H-pyrido[2,...)
Show SMILES CC(C)(C)OC(=O)Cn1c2nc(N)ncc2cc(-c2c(Cl)cccc2Cl)c1=O
Show InChI InChI=1S/C19H18Cl2N4O3/c1-19(2,3)28-14(26)9-25-16-10(8-23-18(22)24-16)7-11(17(25)27)15-12(20)5-4-6-13(15)21/h4-8H,9H2,1-3H3,(H2,22,23,24)
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n/an/a 1.70E+3n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
BindingDB Entry DOI: 10.7270/Q2CC0XWN
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM4056
PNG
(2-[2-amino-6-(2,6-dichlorophenyl)-7-oxo-7H,8H-pyri...)
Show SMILES Nc1ncc2cc(-c3c(Cl)cccc3Cl)c(=O)n(CC(O)=O)c2n1
Show InChI InChI=1S/C15H10Cl2N4O3/c16-9-2-1-3-10(17)12(9)8-4-7-5-19-15(18)20-13(7)21(14(8)24)6-11(22)23/h1-5H,6H2,(H,22,23)(H2,18,19,20)
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PubMed
n/an/a 7.90E+3n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 4365-77 (1998)


Article DOI: 10.1021/jm980398y
BindingDB Entry DOI: 10.7270/Q2CC0XWN
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM3787
PNG
(1-Phenylbenzimidazole deriv. 4 | 1-benzyl-1H-1,3-b...)
Show SMILES C(c1ccccc1)n1cnc2ccccc12
Show InChI InChI=1S/C14H12N2/c1-2-6-12(7-3-1)10-16-11-15-13-8-4-5-9-14(13)16/h1-9,11H,10H2
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n/an/a>5.00E+4n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
BindingDB Entry DOI: 10.7270/Q24T6GJC
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM3788
PNG
(1-Phenylbenzimidazole deriv. 5 | 1-benzoyl-1H-1,3-...)
Show SMILES O=C(c1ccccc1)n1cnc2ccccc12
Show InChI InChI=1S/C14H10N2O/c17-14(11-6-2-1-3-7-11)16-10-15-12-8-4-5-9-13(12)16/h1-10H
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n/an/a>5.00E+4n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
BindingDB Entry DOI: 10.7270/Q24T6GJC
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM3789
PNG
(1-Phenylbenzimidazole Analog 6 | 2-phenyl-1H-1,3-b...)
Show SMILES c1ccc(cc1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C13H10N2/c1-2-6-10(7-3-1)13-14-11-8-4-5-9-12(11)15-13/h1-9H,(H,14,15)
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n/an/a>5.00E+4n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
BindingDB Entry DOI: 10.7270/Q24T6GJC
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM3790
PNG
(1-Phenylbenzimidazole Analog 7 | 4-phenyl-2,3-dihy...)
Show SMILES C1CC(=Nc2ccccc2N1)c1ccccc1
Show InChI InChI=1S/C15H14N2/c1-2-6-12(7-3-1)13-10-11-16-14-8-4-5-9-15(14)17-13/h1-9,16H,10-11H2
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Article
PubMed
n/an/a>5.00E+4n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
BindingDB Entry DOI: 10.7270/Q24T6GJC
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM3791
PNG
(1-Phenylbenzimidazole deriv. 8 | 1-phenyl-1H-indol...)
Show SMILES c1cc2ccccc2n1-c1ccccc1
Show InChI InChI=1S/C14H11N/c1-2-7-13(8-3-1)15-11-10-12-6-4-5-9-14(12)15/h1-11H
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Article
PubMed
n/an/a>5.00E+4n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
BindingDB Entry DOI: 10.7270/Q24T6GJC
More data for this
Ligand-Target Pair
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