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Found 1134 hits Enz. Inhib. hit(s) with Target = 'Beta-glucocerebrosidase'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Beta-glucocerebrosidase


(Mus musculus (Mouse))
BDBM175515
PNG
(US9119845, 16)
Show SMILES OC[C@@H]1[C@@H](O)[C@H](O)CCN1CC1CCNCC1
Show InChI InChI=1S/C12H24N2O3/c15-8-10-12(17)11(16)3-6-14(10)7-9-1-4-13-5-2-9/h9-13,15-17H,1-8H2/t10-,11-,12-/m1/s1
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US Patent
440n/a 1.07E+3n/a 6.90E+3n/an/a4.5n/a



Amicus Therapeautics, Inc.

US Patent


Assay Description
To 2.5 μl of supernatant (in 96-well plates) was added 17.5 μl reaction buffer (citrate phosphate buffer, pH 4.5, no Triton X-100), and 50 ...


US Patent US9119845 (2015)


BindingDB Entry DOI: 10.7270/Q2V40T0P
More data for this
Ligand-Target Pair
Glucosylceramidase


(Homo sapiens (human))
BDBM238210
PNG
(US9402837, 16)
Show SMILES OC[C@H]1CN(CC2CCNCC2)C[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C12H24N2O3/c15-8-10-6-14(7-11(16)12(10)17)5-9-1-3-13-4-2-9/h9-13,15-17H,1-8H2/t10-,11-,12-/m1/s1
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440n/a 1.07E+3n/an/an/an/a4.5n/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
To 2.5 μl of supernatant (in 96-well plates) was added 17.5 μl reaction buffer (citrate phosphate buffer, pH 4.5, no Triton X-100), and 50 μ...


US Patent US9402837 (2016)


BindingDB Entry DOI: 10.7270/Q2MS3RPB
More data for this
Ligand-Target Pair
Glucosylceramidase


(Homo sapiens (human))
BDBM238214
PNG
(US9402837, 24)
Show SMILES CC(C)CCCN1C[C@@H](O)[C@H](O)[C@@H](CO)C1
Show InChI InChI=1S/C12H25NO3/c1-9(2)4-3-5-13-6-10(8-14)12(16)11(15)7-13/h9-12,14-16H,3-8H2,1-2H3/t10-,11-,12-/m1/s1
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880n/a 2.13E+3n/an/an/an/a4.5n/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
To 2.5 μl of supernatant (in 96-well plates) was added 17.5 μl reaction buffer (citrate phosphate buffer, pH 4.5, no Triton X-100), and 50 μ...


US Patent US9402837 (2016)


BindingDB Entry DOI: 10.7270/Q2MS3RPB
More data for this
Ligand-Target Pair
Beta-glucocerebrosidase


(Mus musculus (Mouse))
BDBM175523
PNG
(US9119845, 24)
Show SMILES CC(C)CCCN1CC[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C12H25NO3/c1-9(2)4-3-6-13-7-5-11(15)12(16)10(13)8-14/h9-12,14-16H,3-8H2,1-2H3/t10-,11-,12-/m1/s1
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880n/a 2.13E+3n/a 3.05E+4n/an/a4.5n/a



Amicus Therapeautics, Inc.

US Patent


Assay Description
To 2.5 μl of supernatant (in 96-well plates) was added 17.5 μl reaction buffer (citrate phosphate buffer, pH 4.5, no Triton X-100), and 50 ...


US Patent US9119845 (2015)


BindingDB Entry DOI: 10.7270/Q2V40T0P
More data for this
Ligand-Target Pair
Beta-glucocerebrosidase


(Mus musculus (Mouse))
BDBM175503
PNG
(US9119845, 4)
Show SMILES CC(C)=CCN1CC[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C11H21NO3/c1-8(2)3-5-12-6-4-10(14)11(15)9(12)7-13/h3,9-11,13-15H,4-7H2,1-2H3/t9-,10-,11-/m1/s1
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1.66E+3n/a 4.00E+3n/a 6.30E+4n/an/a4.5n/a



Amicus Therapeautics, Inc.

US Patent


Assay Description
To 2.5 μl of supernatant (in 96-well plates) was added 17.5 μl reaction buffer (citrate phosphate buffer, pH 4.5, no Triton X-100), and 50 ...


US Patent US9119845 (2015)


BindingDB Entry DOI: 10.7270/Q2V40T0P
More data for this
Ligand-Target Pair
Glucosylceramidase


(Homo sapiens (human))
BDBM238200
PNG
(US9402837, 4)
Show SMILES CC(C)=CCN1C[C@@H](O)[C@H](O)[C@@H](CO)C1
Show InChI InChI=1S/C11H21NO3/c1-8(2)3-4-12-5-9(7-13)11(15)10(14)6-12/h3,9-11,13-15H,4-7H2,1-2H3/t9-,10-,11-/m1/s1
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1.66E+3n/a 4.00E+3n/an/an/an/a4.5n/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
To 2.5 μl of supernatant (in 96-well plates) was added 17.5 μl reaction buffer (citrate phosphate buffer, pH 4.5, no Triton X-100), and 50 μ...


US Patent US9402837 (2016)


BindingDB Entry DOI: 10.7270/Q2MS3RPB
More data for this
Ligand-Target Pair
Glucosylceramidase


(Homo sapiens (human))
BDBM238201
PNG
(US9402837, 5)
Show SMILES COCCN1C[C@@H](O)[C@H](O)[C@@H](CO)C1
Show InChI InChI=1S/C9H19NO4/c1-14-3-2-10-4-7(6-11)9(13)8(12)5-10/h7-9,11-13H,2-6H2,1H3/t7-,8-,9-/m1/s1
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2.48E+3n/a 5.99E+3n/an/an/an/a4.5n/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
To 2.5 μl of supernatant (in 96-well plates) was added 17.5 μl reaction buffer (citrate phosphate buffer, pH 4.5, no Triton X-100), and 50 μ...


US Patent US9402837 (2016)


BindingDB Entry DOI: 10.7270/Q2MS3RPB
More data for this
Ligand-Target Pair
Beta-glucocerebrosidase


(Mus musculus (Mouse))
BDBM175504
PNG
(US9119845, 5)
Show SMILES COCCN1CC[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C9H19NO4/c1-14-5-4-10-3-2-8(12)9(13)7(10)6-11/h7-9,11-13H,2-6H2,1H3/t7-,8-,9-/m1/s1
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2.48E+3n/a 5.99E+3n/a 6.07E+4n/an/a4.5n/a



Amicus Therapeautics, Inc.

US Patent


Assay Description
To 2.5 μl of supernatant (in 96-well plates) was added 17.5 μl reaction buffer (citrate phosphate buffer, pH 4.5, no Triton X-100), and 50 ...


US Patent US9119845 (2015)


BindingDB Entry DOI: 10.7270/Q2V40T0P
More data for this
Ligand-Target Pair
Beta-glucocerebrosidase


(Mus musculus (Mouse))
BDBM175512
PNG
(US9119845, 13)
Show SMILES OC[C@@H]1[C@@H](O)[C@H](O)CCN1CCc1ccccc1
Show InChI InChI=1S/C14H21NO3/c16-10-12-14(18)13(17)7-9-15(12)8-6-11-4-2-1-3-5-11/h1-5,12-14,16-18H,6-10H2/t12-,13-,14-/m1/s1
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3.11E+3n/a 7.50E+3n/a 2.20E+3n/an/a4.5n/a



Amicus Therapeautics, Inc.

US Patent


Assay Description
To 2.5 μl of supernatant (in 96-well plates) was added 17.5 μl reaction buffer (citrate phosphate buffer, pH 4.5, no Triton X-100), and 50 ...


US Patent US9119845 (2015)


BindingDB Entry DOI: 10.7270/Q2V40T0P
More data for this
Ligand-Target Pair
Glucosylceramidase


(Homo sapiens (human))
BDBM238208
PNG
(US9402837, 13)
Show SMILES OC[C@H]1CN(CCc2ccccc2)C[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C14H21NO3/c16-10-12-8-15(9-13(17)14(12)18)7-6-11-4-2-1-3-5-11/h1-5,12-14,16-18H,6-10H2/t12-,13-,14-/m1/s1
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3.11E+3n/a 7.50E+3n/an/an/an/a4.5n/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
To 2.5 μl of supernatant (in 96-well plates) was added 17.5 μl reaction buffer (citrate phosphate buffer, pH 4.5, no Triton X-100), and 50 μ...


US Patent US9402837 (2016)


BindingDB Entry DOI: 10.7270/Q2MS3RPB
More data for this
Ligand-Target Pair
Beta-glucocerebrosidase


(Mus musculus (Mouse))
BDBM175511
PNG
(US9119845, 12)
Show SMILES Nc1ccc(CN2CC[C@@H](O)[C@H](O)[C@H]2CO)cc1
Show InChI InChI=1S/C13H20N2O3/c14-10-3-1-9(2-4-10)7-15-6-5-12(17)13(18)11(15)8-16/h1-4,11-13,16-18H,5-8,14H2/t11-,12-,13-/m1/s1
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3.88E+3n/a 9.36E+3n/a 7.70E+3n/an/a4.5n/a



Amicus Therapeautics, Inc.

US Patent


Assay Description
To 2.5 μl of supernatant (in 96-well plates) was added 17.5 μl reaction buffer (citrate phosphate buffer, pH 4.5, no Triton X-100), and 50 ...


US Patent US9119845 (2015)


BindingDB Entry DOI: 10.7270/Q2V40T0P
More data for this
Ligand-Target Pair
Glucosylceramidase


(Homo sapiens (human))
BDBM238207
PNG
(US9402837, 12)
Show SMILES Nc1ccc(CN2C[C@@H](O)[C@H](O)[C@@H](CO)C2)cc1
Show InChI InChI=1S/C13H20N2O3/c14-11-3-1-9(2-4-11)5-15-6-10(8-16)13(18)12(17)7-15/h1-4,10,12-13,16-18H,5-8,14H2/t10-,12-,13-/m1/s1
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3.88E+3n/a 9.36E+3n/an/an/an/a4.5n/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
To 2.5 μl of supernatant (in 96-well plates) was added 17.5 μl reaction buffer (citrate phosphate buffer, pH 4.5, no Triton X-100), and 50 μ...


US Patent US9402837 (2016)


BindingDB Entry DOI: 10.7270/Q2MS3RPB
More data for this
Ligand-Target Pair
Beta-glucocerebrosidase


(Mus musculus (Mouse))
BDBM175507
PNG
(US9119845, 8)
Show SMILES Cc1cccc(CN2CC[C@@H](O)[C@H](O)[C@H]2CO)c1
Show InChI InChI=1S/C14H21NO3/c1-10-3-2-4-11(7-10)8-15-6-5-13(17)14(18)12(15)9-16/h2-4,7,12-14,16-18H,5-6,8-9H2,1H3/t12-,13-,14-/m1/s1
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5.26E+3n/a 1.27E+4n/a 1.16E+4n/an/a4.5n/a



Amicus Therapeautics, Inc.

US Patent


Assay Description
To 2.5 μl of supernatant (in 96-well plates) was added 17.5 μl reaction buffer (citrate phosphate buffer, pH 4.5, no Triton X-100), and 50 ...


US Patent US9119845 (2015)


BindingDB Entry DOI: 10.7270/Q2V40T0P
More data for this
Ligand-Target Pair
Glucosylceramidase


(Homo sapiens (human))
BDBM238204
PNG
(US9402837, 8)
Show SMILES Cc1cccc(CN2C[C@@H](O)[C@H](O)[C@@H](CO)C2)c1
Show InChI InChI=1S/C14H21NO3/c1-10-3-2-4-11(5-10)6-15-7-12(9-16)14(18)13(17)8-15/h2-5,12-14,16-18H,6-9H2,1H3/t12-,13-,14-/m1/s1
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5.26E+3n/a 1.27E+4n/an/an/an/a4.5n/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
To 2.5 μl of supernatant (in 96-well plates) was added 17.5 μl reaction buffer (citrate phosphate buffer, pH 4.5, no Triton X-100), and 50 μ...


US Patent US9402837 (2016)


BindingDB Entry DOI: 10.7270/Q2MS3RPB
More data for this
Ligand-Target Pair
Beta-glucocerebrosidase


(Mus musculus (Mouse))
BDBM175522
PNG
(US9119845, 23)
Show SMILES OC[C@@H]1[C@@H](O)[C@H](O)CCN1CC1CCCC1
Show InChI InChI=1S/C12H23NO3/c14-8-10-12(16)11(15)5-6-13(10)7-9-3-1-2-4-9/h9-12,14-16H,1-8H2/t10-,11-,12-/m1/s1
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6.48E+3n/a 1.56E+4n/a 1.88E+4n/an/a4.5n/a



Amicus Therapeautics, Inc.

US Patent


Assay Description
To 2.5 μl of supernatant (in 96-well plates) was added 17.5 μl reaction buffer (citrate phosphate buffer, pH 4.5, no Triton X-100), and 50 ...


US Patent US9119845 (2015)


BindingDB Entry DOI: 10.7270/Q2V40T0P
More data for this
Ligand-Target Pair
Glucosylceramidase


(Homo sapiens (human))
BDBM238213
PNG
(US9402837, 23)
Show SMILES OC[C@H]1CN(CC2CCCC2)C[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C12H23NO3/c14-8-10-6-13(7-11(15)12(10)16)5-9-3-1-2-4-9/h9-12,14-16H,1-8H2/t10-,11-,12-/m1/s1
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6.48E+3n/a 1.56E+4n/an/an/an/a4.5n/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
To 2.5 μl of supernatant (in 96-well plates) was added 17.5 μl reaction buffer (citrate phosphate buffer, pH 4.5, no Triton X-100), and 50 μ...


US Patent US9402837 (2016)


BindingDB Entry DOI: 10.7270/Q2MS3RPB
More data for this
Ligand-Target Pair
Glucosylceramidase


(Homo sapiens (human))
BDBM238212
PNG
(US9402837, 19)
Show SMILES OC[C@H]1CN(Cc2ccncc2)C[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C12H18N2O3/c15-8-10-6-14(7-11(16)12(10)17)5-9-1-3-13-4-2-9/h1-4,10-12,15-17H,5-8H2/t10-,11-,12-/m1/s1
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8.02E+3n/a 1.94E+4n/an/an/an/a4.5n/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
To 2.5 μl of supernatant (in 96-well plates) was added 17.5 μl reaction buffer (citrate phosphate buffer, pH 4.5, no Triton X-100), and 50 μ...


US Patent US9402837 (2016)


BindingDB Entry DOI: 10.7270/Q2MS3RPB
More data for this
Ligand-Target Pair
Beta-glucocerebrosidase


(Mus musculus (Mouse))
BDBM175518
PNG
(US9119845, 19)
Show SMILES OC[C@@H]1[C@@H](O)[C@H](O)CCN1Cc1ccncc1
Show InChI InChI=1S/C12H18N2O3/c15-8-10-12(17)11(16)3-6-14(10)7-9-1-4-13-5-2-9/h1-2,4-5,10-12,15-17H,3,6-8H2/t10-,11-,12-/m1/s1
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8.02E+3n/a 1.94E+4n/a 3.50E+4n/an/a4.5n/a



Amicus Therapeautics, Inc.

US Patent


Assay Description
To 2.5 μl of supernatant (in 96-well plates) was added 17.5 μl reaction buffer (citrate phosphate buffer, pH 4.5, no Triton X-100), and 50 ...


US Patent US9119845 (2015)


BindingDB Entry DOI: 10.7270/Q2V40T0P
More data for this
Ligand-Target Pair
Beta-glucocerebrosidase


(Mus musculus (Mouse))
BDBM175517
PNG
(US9119845, 18)
Show SMILES OC[C@@H]1[C@@H](O)[C@H](O)CCN1Cc1cccs1
Show InChI InChI=1S/C11H17NO3S/c13-7-9-11(15)10(14)3-4-12(9)6-8-2-1-5-16-8/h1-2,5,9-11,13-15H,3-4,6-7H2/t9-,10-,11-/m1/s1
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1.14E+4n/a 2.76E+4n/a 1.39E+5n/an/a4.5n/a



Amicus Therapeautics, Inc.

US Patent


Assay Description
To 2.5 μl of supernatant (in 96-well plates) was added 17.5 μl reaction buffer (citrate phosphate buffer, pH 4.5, no Triton X-100), and 50 ...


US Patent US9119845 (2015)


BindingDB Entry DOI: 10.7270/Q2V40T0P
More data for this
Ligand-Target Pair
Glucosylceramidase


(Homo sapiens (human))
BDBM238216
PNG
(US9402837, 18)
Show SMILES OC[C@H]1CN(Cc2cccs2)C[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C11H17NO3S/c13-7-8-4-12(6-10(14)11(8)15)5-9-2-1-3-16-9/h1-3,8,10-11,13-15H,4-7H2/t8-,10-,11-/m1/s1
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1.14E+4n/a 2.76E+4n/an/an/an/a4.5n/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
To 2.5 μl of supernatant (in 96-well plates) was added 17.5 μl reaction buffer (citrate phosphate buffer, pH 4.5, no Triton X-100), and 50 μ...


US Patent US9402837 (2016)


BindingDB Entry DOI: 10.7270/Q2MS3RPB
More data for this
Ligand-Target Pair
Beta-glucocerebrosidase


(Mus musculus (Mouse))
BDBM175500
PNG
(US9119845, 1)
Show SMILES CCCN1CC[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C9H19NO3/c1-2-4-10-5-3-8(12)9(13)7(10)6-11/h7-9,11-13H,2-6H2,1H3/t7-,8-,9-/m1/s1
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1.48E+4n/a 3.58E+4n/a 6.59E+4n/an/a4.5n/a



Amicus Therapeautics, Inc.

US Patent


Assay Description
To 2.5 μl of supernatant (in 96-well plates) was added 17.5 μl reaction buffer (citrate phosphate buffer, pH 4.5, no Triton X-100), and 50 ...


US Patent US9119845 (2015)


BindingDB Entry DOI: 10.7270/Q2V40T0P
More data for this
Ligand-Target Pair
Glucosylceramidase


(Homo sapiens (human))
BDBM238197
PNG
(US9402837, 1)
Show SMILES CCCN1C[C@@H](O)[C@H](O)[C@@H](CO)C1
Show InChI InChI=1S/C9H19NO3/c1-2-3-10-4-7(6-11)9(13)8(12)5-10/h7-9,11-13H,2-6H2,1H3/t7-,8-,9-/m1/s1
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1.48E+4n/a 3.58E+4n/an/an/an/a4.5n/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
To 2.5 μl of supernatant (in 96-well plates) was added 17.5 μl reaction buffer (citrate phosphate buffer, pH 4.5, no Triton X-100), and 50 μ...


US Patent US9402837 (2016)


BindingDB Entry DOI: 10.7270/Q2MS3RPB
More data for this
Ligand-Target Pair
Beta-glucocerebrosidase


(Mus musculus (Mouse))
BDBM175502
PNG
(US9119845, 3)
Show SMILES CCCCCCCN1CC[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C13H27NO3/c1-2-3-4-5-6-8-14-9-7-12(16)13(17)11(14)10-15/h11-13,15-17H,2-10H2,1H3/t11-,12-,13-/m1/s1
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US Patent
1.73E+4n/a 4.17E+4n/a 9.99E+3n/an/a4.5n/a



Amicus Therapeautics, Inc.

US Patent


Assay Description
To 2.5 μl of supernatant (in 96-well plates) was added 17.5 μl reaction buffer (citrate phosphate buffer, pH 4.5, no Triton X-100), and 50 ...


US Patent US9119845 (2015)


BindingDB Entry DOI: 10.7270/Q2V40T0P
More data for this
Ligand-Target Pair
Glucosylceramidase


(Homo sapiens (human))
BDBM238199
PNG
(US9402837, 3)
Show SMILES CCCCCCCN1C[C@@H](O)[C@H](O)[C@@H](CO)C1
Show InChI InChI=1S/C13H27NO3/c1-2-3-4-5-6-7-14-8-11(10-15)13(17)12(16)9-14/h11-13,15-17H,2-10H2,1H3/t11-,12-,13-/m1/s1
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1.73E+4n/a 4.17E+4n/an/an/an/a4.5n/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
To 2.5 μl of supernatant (in 96-well plates) was added 17.5 μl reaction buffer (citrate phosphate buffer, pH 4.5, no Triton X-100), and 50 μ...


US Patent US9402837 (2016)


BindingDB Entry DOI: 10.7270/Q2MS3RPB
More data for this
Ligand-Target Pair
Glucosylceramidase


(Homo sapiens (human))
BDBM238215
PNG
(US9402837, 25)
Show SMILES OC[C@H]1CN(Cc2ccc(cc2)[N+]([O-])=O)C[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C13H18N2O5/c16-8-10-6-14(7-12(17)13(10)18)5-9-1-3-11(4-2-9)15(19)20/h1-4,10,12-13,16-18H,5-8H2/t10-,12-,13-/m1/s1
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US Patent
1.86E+4n/a 4.50E+4n/an/an/an/a4.5n/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
To 2.5 μl of supernatant (in 96-well plates) was added 17.5 μl reaction buffer (citrate phosphate buffer, pH 4.5, no Triton X-100), and 50 μ...


US Patent US9402837 (2016)


BindingDB Entry DOI: 10.7270/Q2MS3RPB
More data for this
Ligand-Target Pair
Beta-glucocerebrosidase


(Mus musculus (Mouse))
BDBM175524
PNG
(US9119845, 25)
Show SMILES OC[C@@H]1[C@@H](O)[C@H](O)CCN1Cc1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C13H18N2O5/c16-8-11-13(18)12(17)5-6-14(11)7-9-1-3-10(4-2-9)15(19)20/h1-4,11-13,16-18H,5-8H2/t11-,12-,13-/m1/s1
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US Patent
1.86E+4n/a 4.50E+4n/a 1.64E+4n/an/a4.5n/a



Amicus Therapeautics, Inc.

US Patent


Assay Description
To 2.5 μl of supernatant (in 96-well plates) was added 17.5 μl reaction buffer (citrate phosphate buffer, pH 4.5, no Triton X-100), and 50 ...


US Patent US9119845 (2015)


BindingDB Entry DOI: 10.7270/Q2V40T0P
More data for this
Ligand-Target Pair
Glucosylceramidase


(Homo sapiens (human))
BDBM238209
PNG
(US9402837, 15)
Show SMILES OC[C@H]1CN(CC2CCOCC2)C[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C12H23NO4/c14-8-10-6-13(7-11(15)12(10)16)5-9-1-3-17-4-2-9/h9-12,14-16H,1-8H2/t10-,11-,12-/m1/s1
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2.04E+4n/a 4.92E+4n/an/an/an/a4.5n/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
To 2.5 μl of supernatant (in 96-well plates) was added 17.5 μl reaction buffer (citrate phosphate buffer, pH 4.5, no Triton X-100), and 50 μ...


US Patent US9402837 (2016)


BindingDB Entry DOI: 10.7270/Q2MS3RPB
More data for this
Ligand-Target Pair
Beta-glucocerebrosidase


(Mus musculus (Mouse))
BDBM175514
PNG
(US9119845, 15)
Show SMILES OC[C@@H]1[C@@H](O)[C@H](O)CCN1CC1CCOCC1
Show InChI InChI=1S/C12H23NO4/c14-8-10-12(16)11(15)1-4-13(10)7-9-2-5-17-6-3-9/h9-12,14-16H,1-8H2/t10-,11-,12-/m1/s1
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2.04E+4n/a 4.92E+4n/a 6.83E+4n/an/a4.5n/a



Amicus Therapeautics, Inc.

US Patent


Assay Description
To 2.5 μl of supernatant (in 96-well plates) was added 17.5 μl reaction buffer (citrate phosphate buffer, pH 4.5, no Triton X-100), and 50 ...


US Patent US9119845 (2015)


BindingDB Entry DOI: 10.7270/Q2V40T0P
More data for this
Ligand-Target Pair
Beta-glucocerebrosidase


(Mus musculus (Mouse))
BDBM175506
PNG
(US9119845, 7)
Show SMILES Cc1ccccc1CN1CC[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C14H21NO3/c1-10-4-2-3-5-11(10)8-15-7-6-13(17)14(18)12(15)9-16/h2-5,12-14,16-18H,6-9H2,1H3/t12-,13-,14-/m1/s1
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US Patent
2.88E+4n/a 6.95E+4n/a 4.64E+4n/an/a4.5n/a



Amicus Therapeautics, Inc.

US Patent


Assay Description
To 2.5 μl of supernatant (in 96-well plates) was added 17.5 μl reaction buffer (citrate phosphate buffer, pH 4.5, no Triton X-100), and 50 ...


US Patent US9119845 (2015)


BindingDB Entry DOI: 10.7270/Q2V40T0P
More data for this
Ligand-Target Pair
Glucosylceramidase


(Homo sapiens (human))
BDBM238203
PNG
(US9402837, 7)
Show SMILES Cc1ccccc1CN1C[C@@H](O)[C@H](O)[C@@H](CO)C1
Show InChI InChI=1S/C14H21NO3/c1-10-4-2-3-5-11(10)6-15-7-12(9-16)14(18)13(17)8-15/h2-5,12-14,16-18H,6-9H2,1H3/t12-,13-,14-/m1/s1
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2.88E+4n/a 6.95E+4n/an/an/an/a4.5n/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
To 2.5 μl of supernatant (in 96-well plates) was added 17.5 μl reaction buffer (citrate phosphate buffer, pH 4.5, no Triton X-100), and 50 μ...


US Patent US9402837 (2016)


BindingDB Entry DOI: 10.7270/Q2MS3RPB
More data for this
Ligand-Target Pair
Beta-glucocerebrosidase


(Mus musculus (Mouse))
BDBM175508
PNG
(US9119845, 9)
Show SMILES Cc1ccc(CN2CC[C@@H](O)[C@H](O)[C@H]2CO)cc1
Show InChI InChI=1S/C14H21NO3/c1-10-2-4-11(5-3-10)8-15-7-6-13(17)14(18)12(15)9-16/h2-5,12-14,16-18H,6-9H2,1H3/t12-,13-,14-/m1/s1
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5.37E+4n/a 1.30E+5n/a 1.45E+5n/an/a4.5n/a



Amicus Therapeautics, Inc.

US Patent


Assay Description
To 2.5 μl of supernatant (in 96-well plates) was added 17.5 μl reaction buffer (citrate phosphate buffer, pH 4.5, no Triton X-100), and 50 ...


US Patent US9119845 (2015)


BindingDB Entry DOI: 10.7270/Q2V40T0P
More data for this
Ligand-Target Pair
Glucosylceramidase


(Homo sapiens (human))
BDBM238205
PNG
(US9402837, 9)
Show SMILES Cc1ccc(CN2C[C@@H](O)[C@H](O)[C@@H](CO)C2)cc1
Show InChI InChI=1S/C14H21NO3/c1-10-2-4-11(5-3-10)6-15-7-12(9-16)14(18)13(17)8-15/h2-5,12-14,16-18H,6-9H2,1H3/t12-,13-,14-/m1/s1
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5.37E+4n/a 1.30E+5n/an/an/an/a4.5n/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
To 2.5 μl of supernatant (in 96-well plates) was added 17.5 μl reaction buffer (citrate phosphate buffer, pH 4.5, no Triton X-100), and 50 μ...


US Patent US9402837 (2016)


BindingDB Entry DOI: 10.7270/Q2MS3RPB
More data for this
Ligand-Target Pair
Beta-glucocerebrosidase


(Mus musculus (Mouse))
BDBM175505
PNG
(US9119845, 6)
Show SMILES OC[C@@H]1[C@@H](O)[C@H](O)CCN1Cc1ccccc1
Show InChI InChI=1S/C13H19NO3/c15-9-11-13(17)12(16)6-7-14(11)8-10-4-2-1-3-5-10/h1-5,11-13,15-17H,6-9H2/t11-,12-,13-/m1/s1
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8.30E+4n/a 2.00E+5n/a 1.15E+5n/an/a4.5n/a



Amicus Therapeautics, Inc.

US Patent


Assay Description
To 2.5 μl of supernatant (in 96-well plates) was added 17.5 μl reaction buffer (citrate phosphate buffer, pH 4.5, no Triton X-100), and 50 ...


US Patent US9119845 (2015)


BindingDB Entry DOI: 10.7270/Q2V40T0P
More data for this
Ligand-Target Pair
Glucosylceramidase


(Homo sapiens (human))
BDBM238202
PNG
(US9402837, 6)
Show SMILES OC[C@H]1CN(Cc2ccccc2)C[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C13H19NO3/c15-9-11-7-14(8-12(16)13(11)17)6-10-4-2-1-3-5-10/h1-5,11-13,15-17H,6-9H2/t11-,12-,13-/m1/s1
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8.30E+4n/a 2.00E+5n/an/an/an/a4.5n/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
To 2.5 μl of supernatant (in 96-well plates) was added 17.5 μl reaction buffer (citrate phosphate buffer, pH 4.5, no Triton X-100), and 50 μ...


US Patent US9402837 (2016)


BindingDB Entry DOI: 10.7270/Q2MS3RPB
More data for this
Ligand-Target Pair
Glucosylceramidase


(Homo sapiens (human))
BDBM238206
PNG
(US9402837, 10)
Show SMILES OC[C@H]1CN(Cc2ccc(F)cc2)C[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C13H18FNO3/c14-11-3-1-9(2-4-11)5-15-6-10(8-16)13(18)12(17)7-15/h1-4,10,12-13,16-18H,5-8H2/t10-,12-,13-/m1/s1
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1.12E+5n/a 2.70E+5n/an/an/an/a4.5n/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
To 2.5 μl of supernatant (in 96-well plates) was added 17.5 μl reaction buffer (citrate phosphate buffer, pH 4.5, no Triton X-100), and 50 μ...


US Patent US9402837 (2016)


BindingDB Entry DOI: 10.7270/Q2MS3RPB
More data for this
Ligand-Target Pair
Beta-glucocerebrosidase


(Mus musculus (Mouse))
BDBM175509
PNG
(US9119845, 10)
Show SMILES OC[C@@H]1[C@@H](O)[C@H](O)CCN1Cc1ccc(F)cc1
Show InChI InChI=1S/C13H18FNO3/c14-10-3-1-9(2-4-10)7-15-6-5-12(17)13(18)11(15)8-16/h1-4,11-13,16-18H,5-8H2/t11-,12-,13-/m1/s1
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1.12E+5n/a 2.70E+5n/a 7.06E+4n/an/a4.5n/a



Amicus Therapeautics, Inc.

US Patent


Assay Description
To 2.5 μl of supernatant (in 96-well plates) was added 17.5 μl reaction buffer (citrate phosphate buffer, pH 4.5, no Triton X-100), and 50 ...


US Patent US9119845 (2015)


BindingDB Entry DOI: 10.7270/Q2V40T0P
More data for this
Ligand-Target Pair
Beta-glucocerebrosidase


(Mus musculus (Mouse))
BDBM175516
PNG
(US9119845, 17)
Show SMILES OC[C@@H]1[C@@H](O)[C@H](O)CCN1Cc1ccco1
Show InChI InChI=1S/C11H17NO4/c13-7-9-11(15)10(14)3-4-12(9)6-8-2-1-5-16-8/h1-2,5,9-11,13-15H,3-4,6-7H2/t9-,10-,11-/m1/s1
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1.16E+5n/a 2.80E+5n/a 6.56E+4n/an/a4.5n/a



Amicus Therapeautics, Inc.

US Patent


Assay Description
To 2.5 μl of supernatant (in 96-well plates) was added 17.5 μl reaction buffer (citrate phosphate buffer, pH 4.5, no Triton X-100), and 50 ...


US Patent US9119845 (2015)


BindingDB Entry DOI: 10.7270/Q2V40T0P
More data for this
Ligand-Target Pair
Glucosylceramidase


(Homo sapiens (human))
BDBM238211
PNG
(US9402837, 17)
Show SMILES OC[C@H]1CN(Cc2ccco2)C[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C11H17NO4/c13-7-8-4-12(6-10(14)11(8)15)5-9-2-1-3-16-9/h1-3,8,10-11,13-15H,4-7H2/t8-,10-,11-/m1/s1
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1.16E+5n/a 2.80E+5n/an/an/an/a4.5n/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
To 2.5 μl of supernatant (in 96-well plates) was added 17.5 μl reaction buffer (citrate phosphate buffer, pH 4.5, no Triton X-100), and 50 μ...


US Patent US9402837 (2016)


BindingDB Entry DOI: 10.7270/Q2MS3RPB
More data for this
Ligand-Target Pair
Beta-glucocerebrosidase


(Mus musculus (Mouse))
BDBM175501
PNG
(US9119845, 2)
Show SMILES CCCCCC1CC[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C12H24O3/c1-2-3-4-5-9-6-7-11(14)12(15)10(9)8-13/h9-15H,2-8H2,1H3/t9?,10-,11+,12+/m0/s1
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4.06E+5n/a 9.80E+5n/a 2.66E+5n/an/a4.5n/a



Amicus Therapeautics, Inc.

US Patent


Assay Description
To 2.5 μl of supernatant (in 96-well plates) was added 17.5 μl reaction buffer (citrate phosphate buffer, pH 4.5, no Triton X-100), and 50 ...


US Patent US9119845 (2015)


BindingDB Entry DOI: 10.7270/Q2V40T0P
More data for this
Ligand-Target Pair
Glucosylceramidase


(Homo sapiens (human))
BDBM238198
PNG
(US9402837, 2)
Show SMILES CCCCCN1C[C@@H](O)[C@H](O)[C@@H](CO)C1
Show InChI InChI=1S/C11H23NO3/c1-2-3-4-5-12-6-9(8-13)11(15)10(14)7-12/h9-11,13-15H,2-8H2,1H3/t9-,10-,11-/m1/s1
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4.06E+5n/a 9.80E+5n/an/an/an/a4.5n/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
To 2.5 μl of supernatant (in 96-well plates) was added 17.5 μl reaction buffer (citrate phosphate buffer, pH 4.5, no Triton X-100), and 50 μ...


US Patent US9402837 (2016)


BindingDB Entry DOI: 10.7270/Q2MS3RPB
More data for this
Ligand-Target Pair
Glucosylceramidase


(Homo sapiens (human))
BDBM50383315
PNG
(CHEMBL2029773)
Show SMILES CCCCCCCCSCC[C@H]1NC[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C15H31NO3S/c1-2-3-4-5-6-7-9-20-10-8-12-14(18)15(19)13(17)11-16-12/h12-19H,2-11H2,1H3/t12-,13-,14+,15+/m1/s1
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Article
PubMed
0.400n/an/an/an/an/an/a5.0n/a



University of British Columbia

Curated by ChEMBL


Assay Description
Competitive inhibition of wild type human glucocerebrosidase using 4-methylumbelliferyl beta-D-glucopyranoside as substrate after 15 mins by Dixon an...


J Med Chem 55: 2737-45 (2012)


Article DOI: 10.1021/jm201633y
BindingDB Entry DOI: 10.7270/Q2639QSX
More data for this
Ligand-Target Pair
Glucosylceramidase


(Homo sapiens (human))
BDBM50383327
PNG
(CHEMBL2029772)
Show SMILES CCCCCCSCC[C@H]1NC[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C13H27NO3S/c1-2-3-4-5-7-18-8-6-10-12(16)13(17)11(15)9-14-10/h10-17H,2-9H2,1H3/t10-,11-,12+,13+/m1/s1
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1.80n/an/an/an/an/an/a5.0n/a



University of British Columbia

Curated by ChEMBL


Assay Description
Competitive inhibition of wild type human glucocerebrosidase using 4-methylumbelliferyl beta-D-glucopyranoside as substrate after 15 mins by Dixon an...


J Med Chem 55: 2737-45 (2012)


Article DOI: 10.1021/jm201633y
BindingDB Entry DOI: 10.7270/Q2639QSX
More data for this
Ligand-Target Pair
Glucosylceramidase


(Homo sapiens (human))
BDBM50383321
PNG
(CHEMBL2029780)
Show SMILES O[C@@H]1CN[C@H](CCSCCc2ccccc2)[C@H](O)[C@H]1O
Show InChI InChI=1S/C15H23NO3S/c17-13-10-16-12(14(18)15(13)19)7-9-20-8-6-11-4-2-1-3-5-11/h1-5,12-19H,6-10H2/t12-,13-,14+,15+/m1/s1
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3n/an/an/an/an/an/a5.0n/a



University of British Columbia

Curated by ChEMBL


Assay Description
Competitive inhibition of wild type human glucocerebrosidase using 4-methylumbelliferyl beta-D-glucopyranoside as substrate after 15 mins by Dixon an...


J Med Chem 55: 2737-45 (2012)


Article DOI: 10.1021/jm201633y
BindingDB Entry DOI: 10.7270/Q2639QSX
More data for this
Ligand-Target Pair
Glucosylceramidase


(Homo sapiens (human))
BDBM50383323
PNG
(CHEMBL2029778)
Show SMILES O[C@@H]1CN[C@H](CCSC2CCCCC2)[C@H](O)[C@H]1O
Show InChI InChI=1S/C13H25NO3S/c15-11-8-14-10(12(16)13(11)17)6-7-18-9-4-2-1-3-5-9/h9-17H,1-8H2/t10-,11-,12+,13+/m1/s1
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4n/an/an/an/an/an/a5.0n/a



University of British Columbia

Curated by ChEMBL


Assay Description
Competitive inhibition of wild type human glucocerebrosidase using 4-methylumbelliferyl beta-D-glucopyranoside as substrate after 15 mins by Dixon an...


J Med Chem 55: 2737-45 (2012)


Article DOI: 10.1021/jm201633y
BindingDB Entry DOI: 10.7270/Q2639QSX
More data for this
Ligand-Target Pair
Glucosylceramidase


(Homo sapiens (human))
BDBM50383325
PNG
(CHEMBL2029776)
Show SMILES CC(C)CCSCC[C@H]1NC[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C12H25NO3S/c1-8(2)3-5-17-6-4-9-11(15)12(16)10(14)7-13-9/h8-16H,3-7H2,1-2H3/t9-,10-,11+,12+/m1/s1
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4.40n/an/an/an/an/an/a5.0n/a



University of British Columbia

Curated by ChEMBL


Assay Description
Competitive inhibition of wild type human glucocerebrosidase using 4-methylumbelliferyl beta-D-glucopyranoside as substrate after 15 mins by Dixon an...


J Med Chem 55: 2737-45 (2012)


Article DOI: 10.1021/jm201633y
BindingDB Entry DOI: 10.7270/Q2639QSX
More data for this
Ligand-Target Pair
Glucosylceramidase


(Homo sapiens (human))
BDBM50383324
PNG
(CHEMBL2029777)
Show SMILES O[C@@H]1CN[C@H](CCSC2CCCC2)[C@H](O)[C@H]1O
Show InChI InChI=1S/C12H23NO3S/c14-10-7-13-9(11(15)12(10)16)5-6-17-8-3-1-2-4-8/h8-16H,1-7H2/t9-,10-,11+,12+/m1/s1
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6n/an/an/an/an/an/a5.0n/a



University of British Columbia

Curated by ChEMBL


Assay Description
Competitive inhibition of wild type human glucocerebrosidase using 4-methylumbelliferyl beta-D-glucopyranoside as substrate after 15 mins by Dixon an...


J Med Chem 55: 2737-45 (2012)


Article DOI: 10.1021/jm201633y
BindingDB Entry DOI: 10.7270/Q2639QSX
More data for this
Ligand-Target Pair
Glucosylceramidase


(Homo sapiens (human))
BDBM50383319
PNG
(CHEMBL2029782)
Show SMILES O[C@@H]1CN[C@H](CCSCCNC(=O)Nc2ccccc2)[C@H](O)[C@H]1O
Show InChI InChI=1S/C16H25N3O4S/c20-13-10-18-12(14(21)15(13)22)6-8-24-9-7-17-16(23)19-11-4-2-1-3-5-11/h1-5,12-15,18,20-22H,6-10H2,(H2,17,19,23)/t12-,13-,14+,15+/m1/s1
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12n/an/an/an/an/an/a5.0n/a



University of British Columbia

Curated by ChEMBL


Assay Description
Competitive inhibition of wild type human glucocerebrosidase using 4-methylumbelliferyl beta-D-glucopyranoside as substrate after 15 mins by Dixon an...


J Med Chem 55: 2737-45 (2012)


Article DOI: 10.1021/jm201633y
BindingDB Entry DOI: 10.7270/Q2639QSX
More data for this
Ligand-Target Pair
Glucosylceramidase


(Homo sapiens (human))
BDBM50383328
PNG
(CHEMBL2029771)
Show SMILES CCCCSCC[C@H]1NC[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C11H23NO3S/c1-2-3-5-16-6-4-8-10(14)11(15)9(13)7-12-8/h8-15H,2-7H2,1H3/t8-,9-,10+,11+/m1/s1
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18n/an/an/an/an/an/a5.0n/a



University of British Columbia

Curated by ChEMBL


Assay Description
Competitive inhibition of wild type human glucocerebrosidase using 4-methylumbelliferyl beta-D-glucopyranoside as substrate after 15 mins by Dixon an...


J Med Chem 55: 2737-45 (2012)


Article DOI: 10.1021/jm201633y
BindingDB Entry DOI: 10.7270/Q2639QSX
More data for this
Ligand-Target Pair
Glucosylceramidase


(Homo sapiens (human))
BDBM50383322
PNG
(CHEMBL2029779)
Show SMILES O[C@@H]1CN[C@H](CCSCc2ccccc2)[C@H](O)[C@H]1O
Show InChI InChI=1S/C14H21NO3S/c16-12-8-15-11(13(17)14(12)18)6-7-19-9-10-4-2-1-3-5-10/h1-5,11-18H,6-9H2/t11-,12-,13+,14+/m1/s1
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19n/an/an/an/an/an/a5.0n/a



University of British Columbia

Curated by ChEMBL


Assay Description
Competitive inhibition of wild type human glucocerebrosidase using 4-methylumbelliferyl beta-D-glucopyranoside as substrate after 15 mins by Dixon an...


J Med Chem 55: 2737-45 (2012)


Article DOI: 10.1021/jm201633y
BindingDB Entry DOI: 10.7270/Q2639QSX
More data for this
Ligand-Target Pair
Glucosylceramidase


(Homo sapiens (human))
BDBM50383326
PNG
(CHEMBL2029775)
Show SMILES CC(C)(C)SCC[C@H]1NC[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C11H23NO3S/c1-11(2,3)16-5-4-7-9(14)10(15)8(13)6-12-7/h7-10,12-15H,4-6H2,1-3H3/t7-,8-,9+,10+/m1/s1
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29n/an/an/an/an/an/a5.0n/a



University of British Columbia

Curated by ChEMBL


Assay Description
Competitive inhibition of wild type human glucocerebrosidase using 2,4-dinitrophenyl beta-D-glucopyranoside as substrate after 3 mins by Dixon and Li...


J Med Chem 55: 2737-45 (2012)


Article DOI: 10.1021/jm201633y
BindingDB Entry DOI: 10.7270/Q2639QSX
More data for this
Ligand-Target Pair
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