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Found 752 hits Enz. Inhib. hit(s) with Target = 'Bromodomain-containing protein 2'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Bromodomain-containing protein 2 Bromo 2 domain(BRD2 BD2)


(Homo sapiens (Human))
BDBM179477
PNG
(US9675697, Cpd. No. 44)
Show SMILES COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ccnc(-c3c(C)[nH]c4ccccc34)c21
Show InChI InChI=1S/C26H22N4O2/c1-13-24(16-7-5-6-8-19(16)28-13)26-25-17-12-22(31-4)18(23-14(2)30-32-15(23)3)11-21(17)29-20(25)9-10-27-26/h5-12,28-29H,1-4H3
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n/an/an/a 11n/an/an/a7.4n/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
Biotin labeled BRD proteins (10 μg/ml) in kinetic assay buffer (PBS, pH 7.4, 0.1% BSA and 0.01% Tween-20) were immobilized on Super Streptavidin...


US Patent US9675697 (2017)


BindingDB Entry DOI: 10.7270/Q2CC0XV6
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2 Bromo 2 domain(BRD2 BD2)


(Homo sapiens (Human))
BDBM179477
PNG
(US9675697, Cpd. No. 44)
Show SMILES COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ccnc(-c3c(C)[nH]c4ccccc34)c21
Show InChI InChI=1S/C26H22N4O2/c1-13-24(16-7-5-6-8-19(16)28-13)26-25-17-12-22(31-4)18(23-14(2)30-32-15(23)3)11-21(17)29-20(25)9-10-27-26/h5-12,28-29H,1-4H3
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n/an/an/a 10n/an/an/a7.4n/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
Biotin labeled BRD proteins (10 μg/ml) in kinetic assay buffer (PBS, pH 7.4, 0.1% BSA and 0.01% Tween-20) were immobilized on Super Streptavidin...


US Patent US9675697 (2017)


BindingDB Entry DOI: 10.7270/Q2CC0XV6
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2 Bromo 1 domain(BRD2 BD1)


(Homo sapiens (Human))
BDBM50092341
PNG
(CHEMBL3581660 | US9675697, Cpd. No. 22)
Show SMILES CCc1n[nH]c(CC)c1-c1nccc2[nH]c3cc(-c4c(C)noc4C)c(OC)cc3c12
Show InChI InChI=1S/C24H25N5O2/c1-6-16-23(17(7-2)28-27-16)24-22-14-11-20(30-5)15(21-12(3)29-31-13(21)4)10-19(14)26-18(22)8-9-25-24/h8-11,26H,6-7H2,1-5H3,(H,27,28)
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n/an/an/a 34n/an/an/a7.4n/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
Biotin labeled BRD proteins (10 μg/ml) in kinetic assay buffer (PBS, pH 7.4, 0.1% BSA and 0.01% Tween-20) were immobilized on Super Streptavidin...


US Patent US9675697 (2017)


BindingDB Entry DOI: 10.7270/Q2CC0XV6
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2 Bromo 2 domain(BRD2 BD2)


(Homo sapiens (Human))
BDBM50092341
PNG
(CHEMBL3581660 | US9675697, Cpd. No. 22)
Show SMILES CCc1n[nH]c(CC)c1-c1nccc2[nH]c3cc(-c4c(C)noc4C)c(OC)cc3c12
Show InChI InChI=1S/C24H25N5O2/c1-6-16-23(17(7-2)28-27-16)24-22-14-11-20(30-5)15(21-12(3)29-31-13(21)4)10-19(14)26-18(22)8-9-25-24/h8-11,26H,6-7H2,1-5H3,(H,27,28)
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n/an/an/a 24n/an/an/a7.4n/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
Biotin labeled BRD proteins (10 μg/ml) in kinetic assay buffer (PBS, pH 7.4, 0.1% BSA and 0.01% Tween-20) were immobilized on Super Streptavidin...


US Patent US9675697 (2017)


BindingDB Entry DOI: 10.7270/Q2CC0XV6
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2 Bromo 2 domain(BRD2 BD2)


(Homo sapiens (Human))
BDBM50092341
PNG
(CHEMBL3581660 | US9675697, Cpd. No. 22)
Show SMILES CCc1n[nH]c(CC)c1-c1nccc2[nH]c3cc(-c4c(C)noc4C)c(OC)cc3c12
Show InChI InChI=1S/C24H25N5O2/c1-6-16-23(17(7-2)28-27-16)24-22-14-11-20(30-5)15(21-12(3)29-31-13(21)4)10-19(14)26-18(22)8-9-25-24/h8-11,26H,6-7H2,1-5H3,(H,27,28)
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n/an/an/a 28n/an/an/a7.4n/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
Biotin labeled BRD proteins (10 μg/ml) in kinetic assay buffer (PBS, pH 7.4, 0.1% BSA and 0.01% Tween-20) were immobilized on Super Streptavidin...


US Patent US9675697 (2017)


BindingDB Entry DOI: 10.7270/Q2CC0XV6
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2 Bromo 1 domain(BRD2 BD1)


(Homo sapiens (Human))
BDBM179477
PNG
(US9675697, Cpd. No. 44)
Show SMILES COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ccnc(-c3c(C)[nH]c4ccccc34)c21
Show InChI InChI=1S/C26H22N4O2/c1-13-24(16-7-5-6-8-19(16)28-13)26-25-17-12-22(31-4)18(23-14(2)30-32-15(23)3)11-21(17)29-20(25)9-10-27-26/h5-12,28-29H,1-4H3
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n/an/an/a 34n/an/an/a7.4n/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
Biotin labeled BRD proteins (10 μg/ml) in kinetic assay buffer (PBS, pH 7.4, 0.1% BSA and 0.01% Tween-20) were immobilized on Super Streptavidin...


US Patent US9675697 (2017)


BindingDB Entry DOI: 10.7270/Q2CC0XV6
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2 Bromo 2 domain(BRD2 BD2)


(Homo sapiens (Human))
BDBM50092310
PNG
(CHEMBL3581661 | US9675697, Cpd. No. 23)
Show SMILES COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ccnc(-c3c(C)[nH]nc3C3CC3)c21
Show InChI InChI=1S/C24H23N5O2/c1-11-21(23(28-27-11)14-5-6-14)24-22-15-10-19(30-4)16(20-12(2)29-31-13(20)3)9-18(15)26-17(22)7-8-25-24/h7-10,14,26H,5-6H2,1-4H3,(H,27,28)
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n/an/an/a 20n/an/an/a7.4n/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
Biotin labeled BRD proteins (10 μg/ml) in kinetic assay buffer (PBS, pH 7.4, 0.1% BSA and 0.01% Tween-20) were immobilized on Super Streptavidin...


US Patent US9675697 (2017)


BindingDB Entry DOI: 10.7270/Q2CC0XV6
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2 Bromo 2 domain(BRD2 BD2)


(Homo sapiens (Human))
BDBM50092310
PNG
(CHEMBL3581661 | US9675697, Cpd. No. 23)
Show SMILES COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ccnc(-c3c(C)[nH]nc3C3CC3)c21
Show InChI InChI=1S/C24H23N5O2/c1-11-21(23(28-27-11)14-5-6-14)24-22-15-10-19(30-4)16(20-12(2)29-31-13(20)3)9-18(15)26-17(22)7-8-25-24/h7-10,14,26H,5-6H2,1-4H3,(H,27,28)
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n/an/an/a 13n/an/an/a7.4n/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
Biotin labeled BRD proteins (10 μg/ml) in kinetic assay buffer (PBS, pH 7.4, 0.1% BSA and 0.01% Tween-20) were immobilized on Super Streptavidin...


US Patent US9675697 (2017)


BindingDB Entry DOI: 10.7270/Q2CC0XV6
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2 Bromo 1 domain(BRD2 BD1)


(Homo sapiens (Human))
BDBM179474
PNG
(US9675697, Cpd. No. 25)
Show SMILES COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ccnc(-c3c(C)nnc3-c3ccccc3)c21
Show InChI InChI=1S/C27H21N5O2/c1-14-24(26(31-30-14)17-8-6-5-7-9-17)27-25-18-13-22(33-4)19(23-15(2)32-34-16(23)3)12-21(18)29-20(25)10-11-28-27/h5-13H,1-4H3/b27-24-
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n/an/an/a 41n/an/an/a7.4n/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
Biotin labeled BRD proteins (10 μg/ml) in kinetic assay buffer (PBS, pH 7.4, 0.1% BSA and 0.01% Tween-20) were immobilized on Super Streptavidin...


US Patent US9675697 (2017)


BindingDB Entry DOI: 10.7270/Q2CC0XV6
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2 Bromo 2 domain(BRD2 BD2)


(Homo sapiens (Human))
BDBM179474
PNG
(US9675697, Cpd. No. 25)
Show SMILES COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ccnc(-c3c(C)nnc3-c3ccccc3)c21
Show InChI InChI=1S/C27H21N5O2/c1-14-24(26(31-30-14)17-8-6-5-7-9-17)27-25-18-13-22(33-4)19(23-15(2)32-34-16(23)3)12-21(18)29-20(25)10-11-28-27/h5-13H,1-4H3/b27-24-
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n/an/an/a 36n/an/an/a7.4n/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
Biotin labeled BRD proteins (10 μg/ml) in kinetic assay buffer (PBS, pH 7.4, 0.1% BSA and 0.01% Tween-20) were immobilized on Super Streptavidin...


US Patent US9675697 (2017)


BindingDB Entry DOI: 10.7270/Q2CC0XV6
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2 Bromo 2 domain(BRD2 BD2)


(Homo sapiens (Human))
BDBM179474
PNG
(US9675697, Cpd. No. 25)
Show SMILES COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ccnc(-c3c(C)nnc3-c3ccccc3)c21
Show InChI InChI=1S/C27H21N5O2/c1-14-24(26(31-30-14)17-8-6-5-7-9-17)27-25-18-13-22(33-4)19(23-15(2)32-34-16(23)3)12-21(18)29-20(25)10-11-28-27/h5-13H,1-4H3/b27-24-
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n/an/an/a 36n/an/an/a7.4n/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
Biotin labeled BRD proteins (10 μg/ml) in kinetic assay buffer (PBS, pH 7.4, 0.1% BSA and 0.01% Tween-20) were immobilized on Super Streptavidin...


US Patent US9675697 (2017)


BindingDB Entry DOI: 10.7270/Q2CC0XV6
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2 Bromo 1 domain(BRD2 BD1)


(Homo sapiens (Human))
BDBM50092310
PNG
(CHEMBL3581661 | US9675697, Cpd. No. 23)
Show SMILES COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ccnc(-c3c(C)[nH]nc3C3CC3)c21
Show InChI InChI=1S/C24H23N5O2/c1-11-21(23(28-27-11)14-5-6-14)24-22-15-10-19(30-4)16(20-12(2)29-31-13(20)3)9-18(15)26-17(22)7-8-25-24/h7-10,14,26H,5-6H2,1-4H3,(H,27,28)
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n/an/an/a 26n/an/an/a7.4n/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
Biotin labeled BRD proteins (10 μg/ml) in kinetic assay buffer (PBS, pH 7.4, 0.1% BSA and 0.01% Tween-20) were immobilized on Super Streptavidin...


US Patent US9675697 (2017)


BindingDB Entry DOI: 10.7270/Q2CC0XV6
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2 Bromo 2 domain(BRD2 BD2)


(Homo sapiens (Human))
BDBM50092323
PNG
(CHEMBL3581656 | US9675697, Cpd. No. 21)
Show SMILES COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ccnc(-c3c(C)n[nH]c3C)c21
Show InChI InChI=1S/C22H21N5O2/c1-10-19(11(2)26-25-10)22-21-14-9-18(28-5)15(20-12(3)27-29-13(20)4)8-17(14)24-16(21)6-7-23-22/h6-9,24H,1-5H3,(H,25,26)
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<10<-45.7 93n/an/an/an/a7.525



THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
The FAM labeled fluorescent probe (BRD-1F) was synthesized based on a known small-molecule BET bromodomain inhibitor. Kd values of BRD-1F to these th...


US Patent US9675697 (2017)


BindingDB Entry DOI: 10.7270/Q2CC0XV6
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2 Bromo 2 domain(BRD2 BD2)


(Homo sapiens (Human))
BDBM179460
PNG
(US9675697, Cpd. No. 17)
Show SMILES COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ccnc(-c3c[nH]c4ccccc34)c21
Show InChI InChI=1S/C25H20N4O2/c1-13-23(14(2)31-29-13)17-10-21-16(11-22(17)30-3)24-20(28-21)8-9-26-25(24)18-12-27-19-7-5-4-6-15(18)19/h4-12,27-28H,1-3H3
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<10<-45.7 142n/an/an/an/a7.525



THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
The FAM labeled fluorescent probe (BRD-1F) was synthesized based on a known small-molecule BET bromodomain inhibitor. Kd values of BRD-1F to these th...


US Patent US9675697 (2017)


BindingDB Entry DOI: 10.7270/Q2CC0XV6
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2 Bromo 2 domain(BRD2 BD2)


(Homo sapiens (Human))
BDBM179457
PNG
(US9675697, Cpd. No. 3)
Show SMILES COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ccnc(-c3ccccc3)c21
Show InChI InChI=1S/C23H19N3O2/c1-13-21(14(2)28-26-13)17-11-19-16(12-20(17)27-3)22-18(25-19)9-10-24-23(22)15-7-5-4-6-8-15/h4-12,25H,1-3H3
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35 -42.6 255n/an/an/an/a7.525



THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
The FAM labeled fluorescent probe (BRD-1F) was synthesized based on a known small-molecule BET bromodomain inhibitor. Kd values of BRD-1F to these th...


US Patent US9675697 (2017)


BindingDB Entry DOI: 10.7270/Q2CC0XV6
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2 Bromo 2 domain(BRD2 BD2)


(Homo sapiens (Human))
BDBM50092318
PNG
(CHEMBL3581657 | US9675697, Cpd. No. 2)
Show SMILES COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ccnc(-c3cn[nH]c3)c21
Show InChI InChI=1S/C20H17N5O2/c1-10-18(11(2)27-25-10)14-6-16-13(7-17(14)26-3)19-15(24-16)4-5-21-20(19)12-8-22-23-9-12/h4-9,24H,1-3H3,(H,22,23)
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42.3 -42.1 286n/an/an/an/a7.525



THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
The FAM labeled fluorescent probe (BRD-1F) was synthesized based on a known small-molecule BET bromodomain inhibitor. Kd values of BRD-1F to these th...


US Patent US9675697 (2017)


BindingDB Entry DOI: 10.7270/Q2CC0XV6
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2 Bromo 2 domain(BRD2 BD2)


(Homo sapiens (Human))
BDBM179458
PNG
(US9675697, Cpd. No. 4)
Show SMILES COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ccnc(-c3cccnc3)c21
Show InChI InChI=1S/C22H18N4O2/c1-12-20(13(2)28-26-12)16-9-18-15(10-19(16)27-3)21-17(25-18)6-8-24-22(21)14-5-4-7-23-11-14/h4-11,25H,1-3H3
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57 -41.3 349n/an/an/an/a7.525



THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
The FAM labeled fluorescent probe (BRD-1F) was synthesized based on a known small-molecule BET bromodomain inhibitor. Kd values of BRD-1F to these th...


US Patent US9675697 (2017)


BindingDB Entry DOI: 10.7270/Q2CC0XV6
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2 Bromo 2 domain(BRD2 BD2)


(Homo sapiens (Human))
BDBM50092339
PNG
(CHEMBL3581648 | US9675697, RX-7)
Show SMILES COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ccncc21
Show InChI InChI=1S/C17H15N3O2/c1-9-17(10(2)22-20-9)12-6-15-11(7-16(12)21-3)13-8-18-5-4-14(13)19-15/h4-8,19H,1-3H3
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366 -36.7 1.35E+3n/an/an/an/a7.525



THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
The FAM labeled fluorescent probe (BRD-1F) was synthesized based on a known small-molecule BET bromodomain inhibitor. Kd values of BRD-1F to these th...


US Patent US9675697 (2017)


BindingDB Entry DOI: 10.7270/Q2CC0XV6
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2 Bromo 2 domain(BRD2 BD2)


(Homo sapiens (Human))
BDBM179476
PNG
(US9675697, Cpd. No. 34)
Show SMILES COc1cc2c(cc1-c1c(C)n[nH]c1C)[nH]c1ccnc(-c3c(C)n[nH]c3C)c21
Show InChI InChI=1S/C22H22N6O/c1-10-19(11(2)26-25-10)15-8-17-14(9-18(15)29-5)21-16(24-17)6-7-23-22(21)20-12(3)27-28-13(20)4/h6-9,24H,1-5H3,(H,25,26)(H,27,28)
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1.20E+3 -33.8 3.20E+3n/an/an/an/a7.525



THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
The FAM labeled fluorescent probe (BRD-1F) was synthesized based on a known small-molecule BET bromodomain inhibitor. Kd values of BRD-1F to these th...


US Patent US9675697 (2017)


BindingDB Entry DOI: 10.7270/Q2CC0XV6
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM274262
PNG
(6-(4-chlorophenyl)-5-(1,5-dimethyl-6-oxo-1,6-dihyd...)
Show SMILES COc1cccc(n1)-c1cc2C(=O)N(C(c2n1C)c1ccc(Cl)cc1)c1cc(C)c(=O)n(C)c1
Show InChI InChI=1S/C26H23ClN4O3/c1-15-12-18(14-29(2)25(15)32)31-23(16-8-10-17(27)11-9-16)24-19(26(31)33)13-21(30(24)3)20-6-5-7-22(28-20)34-4/h5-14,23H,1-4H3
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n/an/a 80n/an/an/an/a7.5n/a



NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9550796 (2017)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM274263
PNG
(6-(4-chlorophenyl)-1-cyclopropyl-5-(1,5-dimethyl-6...)
Show SMILES Cc1cc(cn(C)c1=O)N1C(c2c(ccn2C2CC2)C1=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H20ClN3O2/c1-13-11-17(12-24(2)21(13)27)26-19(14-3-5-15(23)6-4-14)20-18(22(26)28)9-10-25(20)16-7-8-16/h3-6,9-12,16,19H,7-8H2,1-2H3
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NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9550796 (2017)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM274264
PNG
(5-(5-chloro-1-methyl-6-oxo-1,6-dihydropyridin-3-yl...)
Show SMILES Cn1cc(cc(Cl)c1=O)N1C(c2c(cc(-c3cccc(=O)n3C)n2C2CC2)C1=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C27H22Cl2N4O3/c1-30-14-18(12-20(29)27(30)36)33-24(15-6-8-16(28)9-7-15)25-19(26(33)35)13-22(32(25)17-10-11-17)21-4-3-5-23(34)31(21)2/h3-9,12-14,17,24H,10-11H2,1-2H3
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n/an/a 140n/an/an/an/a7.5n/a



NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9550796 (2017)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM274265
PNG
(6-(4-chlorophenyl)-1-cyclopropyl-5-(1,5-dimethyl-6...)
Show SMILES Cc1cc(cn(C)c1=O)N1C(c2c(cc(-c3cccc(=O)n3C)n2C2CC2)C1=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C28H25ClN4O3/c1-16-13-20(15-30(2)27(16)35)33-25(17-7-9-18(29)10-8-17)26-21(28(33)36)14-23(32(26)19-11-12-19)22-5-4-6-24(34)31(22)3/h4-10,13-15,19,25H,11-12H2,1-3H3
PDB

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NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9550796 (2017)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM274266
PNG
(5-(5-chloro-1-methyl-6-oxo-1,6-dihydropyridin-3-yl...)
Show SMILES Cn1cccc(-c2cc3C(=O)N(C(c3n2C2CC2)c2ccc(Cl)cc2)c2cc(Cl)c(=O)n(C)c2)c1=O
Show InChI InChI=1S/C27H22Cl2N4O3/c1-30-11-3-4-19(25(30)34)22-13-20-24(32(22)17-9-10-17)23(15-5-7-16(28)8-6-15)33(26(20)35)18-12-21(29)27(36)31(2)14-18/h3-8,11-14,17,23H,9-10H2,1-2H3
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NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9550796 (2017)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM274267
PNG
(6-(4-chlorophenyl)-1-cyclopropyl-5-(1,5-dimethyl-6...)
Show SMILES Cc1cc(cn(C)c1=O)N1C(c2c(cc(-c3cccn(C)c3=O)n2C2CC2)C1=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C28H25ClN4O3/c1-16-13-20(15-31(3)26(16)34)33-24(17-6-8-18(29)9-7-17)25-22(28(33)36)14-23(32(25)19-10-11-19)21-5-4-12-30(2)27(21)35/h4-9,12-15,19,24H,10-11H2,1-3H3
PDB

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NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9550796 (2017)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM274268
PNG
(5-(5-chloro-1-methyl-6-oxo-1,6-dihydropyridin-3-yl...)
Show SMILES Cn1cc(ccc1=O)-c1cc2C(=O)N(C(c2n1C1CC1)c1ccc(Cl)cc1)c1cc(Cl)c(=O)n(C)c1
Show InChI InChI=1S/C27H22Cl2N4O3/c1-30-13-16(5-10-23(30)34)22-12-20-25(32(22)18-8-9-18)24(15-3-6-17(28)7-4-15)33(26(20)35)19-11-21(29)27(36)31(2)14-19/h3-7,10-14,18,24H,8-9H2,1-2H3
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NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9550796 (2017)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM274269
PNG
(6-(4-chlorophenyl)-1-cyclopropyl-5-(1,5-dimethyl-6...)
Show SMILES Cc1cc(cn(C)c1=O)N1C(c2c(cc(-c3ccc(=O)n(C)c3)n2C2CC2)C1=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C28H25ClN4O3/c1-16-12-21(15-31(3)27(16)35)33-25(17-4-7-19(29)8-5-17)26-22(28(33)36)13-23(32(26)20-9-10-20)18-6-11-24(34)30(2)14-18/h4-8,11-15,20,25H,9-10H2,1-3H3
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NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9550796 (2017)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM274270
PNG
(6-(4-chlorophenyl)-2-cyclopropyl-5-(1,5-dimethyl-6...)
Show SMILES Cc1cc(cn(C)c1=O)N1C(c2c(cc(C3CC3)n2C)C1=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H22ClN3O2/c1-13-10-17(12-25(2)22(13)28)27-20(15-6-8-16(24)9-7-15)21-18(23(27)29)11-19(26(21)3)14-4-5-14/h6-12,14,20H,4-5H2,1-3H3
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NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9550796 (2017)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM274271
PNG
(6-(4-chlorophenyl)-5-(1,5-dimethyl-6-oxo-1,6-dihyd...)
Show SMILES Cc1cc2C(=O)N(C(c2n1C)c1ccc(Cl)cc1)c1cc(C)c(=O)n(C)c1
Show InChI InChI=1S/C21H20ClN3O2/c1-12-9-16(11-23(3)20(12)26)25-18(14-5-7-15(22)8-6-14)19-17(21(25)27)10-13(2)24(19)4/h5-11,18H,1-4H3
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NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9550796 (2017)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM274272
PNG
(6-(4-chlorophenyl)-5-(1,5-dimethyl-6-oxo-1,6-dihyd...)
Show SMILES Cc1cc(cn(C)c1=O)N1C(c2c(ccn2C)C1=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H18ClN3O2/c1-12-10-15(11-23(3)19(12)25)24-17(13-4-6-14(21)7-5-13)18-16(20(24)26)8-9-22(18)2/h4-11,17H,1-3H3
PDB

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NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9550796 (2017)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM274274
PNG
((R)-5-(5-chloro-1-methyl-6-oxo-1,6-dihydropyridin-...)
Show SMILES Cc1cc2C(=O)N([C@@H](c2n1C)c1ccc(Cl)cc1)c1cc(Cl)c(=O)n(C)c1
Show InChI InChI=1S/C20H17Cl2N3O2/c1-11-8-15-18(24(11)3)17(12-4-6-13(21)7-5-12)25(19(15)26)14-9-16(22)20(27)23(2)10-14/h4-10,17H,1-3H3/t17-/m1/s1
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NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9550796 (2017)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM274293
PNG
(6-(4-chlorophenyl)-5-(3,7-dimethyl-3H-[1,2,3]triaz...)
Show SMILES CN(C)C(=O)c1cn(C)c2C(N(C(=O)c12)c1cc(C)c2nnn(C)c2n1)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H22ClN7O2/c1-12-10-16(25-21-18(12)26-27-30(21)5)31-19(13-6-8-14(24)9-7-13)20-17(23(31)33)15(11-29(20)4)22(32)28(2)3/h6-11,19H,1-5H3
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NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9550796 (2017)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM274294
PNG
(Tert-butyl (6-(4-chlorophenyl)-5-(3,7-dimethyl-3H-...)
Show SMILES Cc1cc(nc2n(C)nnc12)N1C(c2c(C1=O)c(NC(=O)OC(C)(C)C)cn2C)c1ccc(Cl)cc1
Show InChI InChI=1S/C25H26ClN7O3/c1-13-11-17(28-22-19(13)29-30-32(22)6)33-20(14-7-9-15(26)10-8-14)21-18(23(33)34)16(12-31(21)5)27-24(35)36-25(2,3)4/h7-12,20H,1-6H3,(H,27,35)
PDB

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NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9550796 (2017)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM274295
PNG
(N-(6-(4-chlorophenyl)-5-(3,7-dimethyl-3H-[1,2,3]tr...)
Show SMILES CC(=O)Nc1cn(C)c2C(N(C(=O)c12)c1cc(C)c2nnn(C)c2n1)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H20ClN7O2/c1-11-9-16(25-21-18(11)26-27-29(21)4)30-19(13-5-7-14(23)8-6-13)20-17(22(30)32)15(10-28(20)3)24-12(2)31/h5-10,19H,1-4H3,(H,24,31)
PDB

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NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9550796 (2017)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM274296
PNG
(Ethyl (6-(4-chlorophenyl)-5-(3,7-dimethyl-3H-[1,2,...)
Show SMILES CCOC(=O)Nc1cn(C)c2C(N(C(=O)c12)c1cc(C)c2nnn(C)c2n1)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H22ClN7O3/c1-5-34-23(33)25-15-11-29(3)20-17(15)22(32)31(19(20)13-6-8-14(24)9-7-13)16-10-12(2)18-21(26-16)30(4)28-27-18/h6-11,19H,5H2,1-4H3,(H,25,33)
PDB

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NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9550796 (2017)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM274298
PNG
(6-(4-chlorophenyl)-5-(3,8-dimethyl-[1,2,4]triazolo...)
Show SMILES CNC(=O)c1cn(C)c2C(N(C(=O)c12)c1cc(C)c2nnc(C)n2c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H21ClN6O2/c1-12-9-16(10-29-13(2)26-27-21(12)29)30-19(14-5-7-15(24)8-6-14)20-18(23(30)32)17(11-28(20)4)22(31)25-3/h5-11,19H,1-4H3,(H,25,31)
PDB

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NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9550796 (2017)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM274299
PNG
(6-(4-chlorophenyl)-5-(3,8-dimethyl-[1,2,4]triazolo...)
Show SMILES CN(C)C(=O)c1cn(C)c2C(N(C(=O)c12)c1cc(C)c2nnc(C)n2c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H23ClN6O2/c1-13-10-17(11-30-14(2)26-27-22(13)30)31-20(15-6-8-16(25)9-7-15)21-19(24(31)33)18(12-29(21)5)23(32)28(3)4/h6-12,20H,1-5H3
PDB

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NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9550796 (2017)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM274300
PNG
(6-(4-chlorophenyl)-5-(3,8-dimethyl-[1,2,4]triazolo...)
Show SMILES Cc1nnc2c(C)cc(cn12)N1C(c2c(C1=O)c(cn2C)C(N)=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H19ClN6O2/c1-11-8-15(9-28-12(2)25-26-21(11)28)29-18(13-4-6-14(23)7-5-13)19-17(22(29)31)16(20(24)30)10-27(19)3/h4-10,18H,1-3H3,(H2,24,30)
PDB

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NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9550796 (2017)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM274301
PNG
(Tert-butyl (6-(4-chlorophenyl)-5-(3,8-dimethyl-[1,...)
Show SMILES Cc1nnc2c(C)cc(cn12)N1C(c2c(C1=O)c(NC(=O)OC(C)(C)C)cn2C)c1ccc(Cl)cc1
Show InChI InChI=1S/C26H27ClN6O3/c1-14-11-18(12-32-15(2)29-30-23(14)32)33-21(16-7-9-17(27)10-8-16)22-20(24(33)34)19(13-31(22)6)28-25(35)36-26(3,4)5/h7-13,21H,1-6H3,(H,28,35)
PDB

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NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9550796 (2017)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM274302
PNG
(N-(6-(4-chlorophenyl)-5-(3,8-dimethyl-[1,2,4]triaz...)
Show SMILES CC(=O)Nc1cn(C)c2C(N(C(=O)c12)c1cc(C)c2nnc(C)n2c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H21ClN6O2/c1-12-9-17(10-29-13(2)26-27-22(12)29)30-20(15-5-7-16(24)8-6-15)21-19(23(30)32)18(11-28(21)4)25-14(3)31/h5-11,20H,1-4H3,(H,25,31)
PDB

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NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9550796 (2017)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM274303
PNG
(6-(4-chlorophenyl)-3-cyclopropyl-5-(3,7-dimethyl-3...)
Show SMILES Cc1cc(nc2n(C)nnc12)N1C(c2c(C1=O)c(cn2C1COC1)C1CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C25H23ClN6O2/c1-13-9-19(27-24-21(13)28-29-30(24)2)32-22(15-5-7-16(26)8-6-15)23-20(25(32)33)18(14-3-4-14)10-31(23)17-11-34-12-17/h5-10,14,17,22H,3-4,11-12H2,1-2H3
PDB

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NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9550796 (2017)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM274304
PNG
(1-(1-acetylazetidin-3-yl)-6-(4-chlorophenyl)-3-cyc...)
Show SMILES CC(=O)N1CC(C1)n1cc(C2CC2)c2C(=O)N(C(c12)c1ccc(Cl)cc1)c1cc(C)c2nnn(C)c2n1
Show InChI InChI=1S/C27H26ClN7O2/c1-14-10-21(29-26-23(14)30-31-32(26)3)35-24(17-6-8-18(28)9-7-17)25-22(27(35)37)20(16-4-5-16)13-34(25)19-11-33(12-19)15(2)36/h6-10,13,16,19,24H,4-5,11-12H2,1-3H3
PDB

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NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9550796 (2017)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM274305
PNG
(6-(4-chlorophenyl)-3-cyclopropyl-5-(3,7-dimethyl-3...)
Show SMILES CN1CC(C1)n1cc(C2CC2)c2C(=O)N(C(c12)c1ccc(Cl)cc1)c1cc(C)c2nnn(C)c2n1
Show InChI InChI=1S/C26H26ClN7O/c1-14-10-20(28-25-22(14)29-30-32(25)3)34-23(16-6-8-17(27)9-7-16)24-21(26(34)35)19(15-4-5-15)13-33(24)18-11-31(2)12-18/h6-10,13,15,18,23H,4-5,11-12H2,1-3H3
PDB

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NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9550796 (2017)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM274209
PNG
(6-(4-chlorophenyl)-5-(3,7-dimethyl-3H-[1,2,3]triaz...)
Show SMILES COCn1cc(C)c2C(=O)N(C(c12)c1ccc(Cl)cc1)c1cc(C)c2nnn(C)c2n1
Show InChI InChI=1S/C22H21ClN6O2/c1-12-9-16(24-21-18(12)25-26-27(21)3)29-19(14-5-7-15(23)8-6-14)20-17(22(29)30)13(2)10-28(20)11-31-4/h5-10,19H,11H2,1-4H3
PDB

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NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9550796 (2017)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM274210
PNG
(6-(4-chlorophenyl)-5-(3,8-di methyl-[1,2,4]triazol...)
Show SMILES Cc1c[nH]c2C(N(C(=O)c12)c1cc(C)c2nnc(C)n2c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H18ClN5O/c1-11-8-16(10-26-13(3)24-25-20(11)26)27-19(14-4-6-15(22)7-5-14)18-17(21(27)28)12(2)9-23-18/h4-10,19,23H,1-3H3
PDB

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NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9550796 (2017)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM274211
PNG
(6-(4-chlorophenyl)-5-(3,8-di methyl-[1,2,4]triazol...)
Show SMILES CN1CC(C1)n1cc(C)c2C(=O)N(C(c12)c1ccc(Cl)cc1)c1cc(C)c2nnc(C)n2c1
Show InChI InChI=1S/C25H25ClN6O/c1-14-9-19(13-30-16(3)27-28-24(14)30)32-22(17-5-7-18(26)8-6-17)23-21(25(32)33)15(2)10-31(23)20-11-29(4)12-20/h5-10,13,20,22H,11-12H2,1-4H3
PDB

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NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9550796 (2017)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM274212
PNG
(6-(4-chlorophenyl)-5-(3,8-dimethyl-[1,2,4]triazolo...)
Show SMILES Cc1cn(C2COC2)c2C(N(C(=O)c12)c1cc(C)c2nnc(C)n2c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H22ClN5O2/c1-13-8-18(10-28-15(3)26-27-23(13)28)30-21(16-4-6-17(25)7-5-16)22-20(24(30)31)14(2)9-29(22)19-11-32-12-19/h4-10,19,21H,11-12H2,1-3H3
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NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9550796 (2017)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM274213
PNG
(1-(1-acetylazetidin-3-yl)-6-(4-chlorophenyl)-5-(3,...)
Show SMILES CC(=O)N1CC(C1)n1cc(C)c2C(=O)N(C(c12)c1ccc(Cl)cc1)c1cc(C)c2nnc(C)n2c1
Show InChI InChI=1S/C26H25ClN6O2/c1-14-9-20(13-31-16(3)28-29-25(14)31)33-23(18-5-7-19(27)8-6-18)24-22(26(33)35)15(2)10-32(24)21-11-30(12-21)17(4)34/h5-10,13,21,23H,11-12H2,1-4H3
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NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9550796 (2017)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM274214
PNG
(Ethyl 3-(6-(4-chlorophenyl)-5-(3,8-dimethyl-[1,2,4...)
Show SMILES CCOC(=O)N1CC(C1)n1cc(C)c2C(=O)N(C(c12)c1ccc(Cl)cc1)c1cc(C)c2nnc(C)n2c1
Show InChI InChI=1S/C27H27ClN6O3/c1-5-37-27(36)31-12-21(13-31)33-11-16(3)22-24(33)23(18-6-8-19(28)9-7-18)34(26(22)35)20-10-15(2)25-30-29-17(4)32(25)14-20/h6-11,14,21,23H,5,12-13H2,1-4H3
PDB

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NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9550796 (2017)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM274215
PNG
(6-(4-chlorophenyl)-5-(3,8-dimethyl-[1,2,4]triazolo...)
Show SMILES CNC(=O)n1cc(C)c2C(=O)N(C(c12)c1ccc(Cl)cc1)c1cc(C)c2nnc(C)n2c1
Show InChI InChI=1S/C23H21ClN6O2/c1-12-9-17(11-28-14(3)26-27-21(12)28)30-19(15-5-7-16(24)8-6-15)20-18(22(30)31)13(2)10-29(20)23(32)25-4/h5-11,19H,1-4H3,(H,25,32)
PDB

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NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9550796 (2017)

More data for this
Ligand-Target Pair
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