BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 585 hits Enz. Inhib. hit(s) with Target = 'Bromodomain-containing protein 4 (BRD4)(aa 57-168)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Bromodomain-containing protein 4 (BRD4)(aa 57-168)


(Homo sapiens (Human))
BDBM220432
PNG
(US9296741, 21)
Show SMILES CCS(=O)(=O)Nc1ccc(Oc2ccccc2)c(c1)-c1cn(C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C22H21N3O4S/c1-3-30(27,28)24-15-9-10-20(29-16-7-5-4-6-8-16)18(13-15)19-14-25(2)22(26)21-17(19)11-12-23-21/h4-14,23-24H,3H2,1-2H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
0.390 -53.7n/an/an/an/an/a6.025



AbbVie Inc

US Patent


Assay Description
A time-resolved fluorescence resonance energy transfer (TR-FRET) assay was used to determine the affinities of compounds of the Examples listed in Ta...


US Patent US9296741 (2016)


BindingDB Entry DOI: 10.7270/Q26W98ZQ
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)(aa 57-168)


(Homo sapiens (Human))
BDBM220518
PNG
(US9296741, 107)
Show SMILES Cn1cc(-c2cc(NS(=O)(=O)CC(F)(F)F)ccc2OC2CCCOC2)c2cc[nH]c2c1=O
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
0.5 -53.1n/an/an/an/an/a6.025



AbbVie Inc

US Patent


Assay Description
A time-resolved fluorescence resonance energy transfer (TR-FRET) assay was used to determine the affinities of compounds of the Examples listed in Ta...


US Patent US9296741 (2016)


BindingDB Entry DOI: 10.7270/Q26W98ZQ
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)(aa 57-168)


(Homo sapiens (Human))
BDBM220516
PNG
(US9296741, 105)
Show SMILES CCS(=O)(=O)Nc1ccc(OC2CCCOC2)c(c1)-c1cn(C)c(=O)c2[nH]ccc12
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
0.520 -53.0n/an/an/an/an/a6.025



AbbVie Inc

US Patent


Assay Description
A time-resolved fluorescence resonance energy transfer (TR-FRET) assay was used to determine the affinities of compounds of the Examples listed in Ta...


US Patent US9296741 (2016)


BindingDB Entry DOI: 10.7270/Q26W98ZQ
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)(aa 57-168)


(Homo sapiens (Human))
BDBM220507
PNG
(US9296741, 96)
Show SMILES Cn1cc(-c2cc(cnc2NC2CCCCC2)S(N)(=O)=O)c2cc[nH]c2c1=O
Show InChI InChI=1S/C19H23N5O3S/c1-24-11-16(14-7-8-21-17(14)19(24)25)15-9-13(28(20,26)27)10-22-18(15)23-12-5-3-2-4-6-12/h7-12,21H,2-6H2,1H3,(H,22,23)(H2,20,26,27)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
0.630 -52.5n/an/an/an/an/a6.025



AbbVie Inc

US Patent


Assay Description
A time-resolved fluorescence resonance energy transfer (TR-FRET) assay was used to determine the affinities of compounds of the Examples listed in Ta...


US Patent US9296741 (2016)


BindingDB Entry DOI: 10.7270/Q26W98ZQ
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)(aa 57-168)


(Homo sapiens (Human))
BDBM220614
PNG
(US9296741, 203)
Show SMILES CCS(=O)(=O)c1ccc(O[C@H]2CC[C@H](O)CC2)c(c1)-c1cn(C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C22H26N2O5S/c1-3-30(27,28)16-8-9-20(29-15-6-4-14(25)5-7-15)18(12-16)19-13-24(2)22(26)21-17(19)10-11-23-21/h8-15,23,25H,3-7H2,1-2H3/t14-,15-
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
0.690 -52.3n/an/an/an/an/a6.025



AbbVie Inc

US Patent


Assay Description
A time-resolved fluorescence resonance energy transfer (TR-FRET) assay was used to determine the affinities of compounds of the Examples listed in Ta...


US Patent US9296741 (2016)


BindingDB Entry DOI: 10.7270/Q26W98ZQ
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)(aa 57-168)


(Homo sapiens (Human))
BDBM220520
PNG
(US9296741, 109)
Show SMILES CCS(=O)(=O)Nc1ccc(OC2CCOCC2)c(c1)-c1cn(C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C21H25N3O5S/c1-3-30(26,27)23-14-4-5-19(29-15-7-10-28-11-8-15)17(12-14)18-13-24(2)21(25)20-16(18)6-9-22-20/h4-6,9,12-13,15,22-23H,3,7-8,10-11H2,1-2H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
0.720 -52.2n/an/an/an/an/a6.025



AbbVie Inc

US Patent


Assay Description
A time-resolved fluorescence resonance energy transfer (TR-FRET) assay was used to determine the affinities of compounds of the Examples listed in Ta...


US Patent US9296741 (2016)


BindingDB Entry DOI: 10.7270/Q26W98ZQ
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)(aa 57-168)


(Homo sapiens (Human))
BDBM220477
PNG
(US9296741, 66)
Show SMILES CCS(=O)(=O)Nc1ccc(OC2CCOC2)c(c1)-c1cn(C)c(=O)c2[nH]ccc12
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
0.740 -52.1n/an/an/an/an/a6.025



AbbVie Inc

US Patent


Assay Description
A time-resolved fluorescence resonance energy transfer (TR-FRET) assay was used to determine the affinities of compounds of the Examples listed in Ta...


US Patent US9296741 (2016)


BindingDB Entry DOI: 10.7270/Q26W98ZQ
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)(aa 57-168)


(Homo sapiens (Human))
BDBM220471
PNG
(US9296741, 60)
Show SMILES Cn1cc(-c2cc(NS(C)(=O)=O)ccc2OC2CCCOC2)c2cc[nH]c2c1=O
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
0.75 -52.1n/an/an/an/an/a6.025



AbbVie Inc

US Patent


Assay Description
A time-resolved fluorescence resonance energy transfer (TR-FRET) assay was used to determine the affinities of compounds of the Examples listed in Ta...


US Patent US9296741 (2016)


BindingDB Entry DOI: 10.7270/Q26W98ZQ
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)(aa 57-168)


(Homo sapiens (Human))
BDBM220679
PNG
(US9296741, 268)
Show SMILES CCS(=O)(=O)c1ccc(OC2CCC(C)(CC2)OC)c(c1)-c1cn(C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C24H30N2O5S/c1-5-32(28,29)17-6-7-21(31-16-8-11-24(2,30-4)12-9-16)19(14-17)20-15-26(3)23(27)22-18(20)10-13-25-22/h6-7,10,13-16,25H,5,8-9,11-12H2,1-4H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
0.760 -52.0n/an/an/an/an/a6.025



AbbVie Inc

US Patent


Assay Description
A time-resolved fluorescence resonance energy transfer (TR-FRET) assay was used to determine the affinities of compounds of the Examples listed in Ta...


US Patent US9296741 (2016)


BindingDB Entry DOI: 10.7270/Q26W98ZQ
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)(aa 57-168)


(Homo sapiens (Human))
BDBM220750
PNG
(US9296741, 339)
Show SMILES CCS(=O)(=O)Nc1ccc(Oc2ccc(F)cc2F)c(c1)-c1cn(C)c(=O)c2[nH]c(CN3CCN(C)CC3)cc12
Show InChI InChI=1S/C28H31F2N5O4S/c1-4-40(37,38)32-19-6-8-25(39-26-7-5-18(29)13-24(26)30)21(14-19)23-17-34(3)28(36)27-22(23)15-20(31-27)16-35-11-9-33(2)10-12-35/h5-8,13-15,17,31-32H,4,9-12,16H2,1-3H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
0.800 -51.9n/an/an/an/an/a6.025



AbbVie Inc

US Patent


Assay Description
A time-resolved fluorescence resonance energy transfer (TR-FRET) assay was used to determine the affinities of compounds of the Examples listed in Ta...


US Patent US9296741 (2016)


BindingDB Entry DOI: 10.7270/Q26W98ZQ
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)(aa 57-168)


(Homo sapiens (Human))
BDBM220482
PNG
(US9296741, 71)
Show SMILES CCOC(=O)c1cc2c(cn(C)c(=O)c2[nH]1)-c1cc(NS(C)(=O)=O)ccc1Oc1ccccc1
Show InChI InChI=1S/C24H23N3O6S/c1-4-32-24(29)20-13-18-19(14-27(2)23(28)22(18)25-20)17-12-15(26-34(3,30)31)10-11-21(17)33-16-8-6-5-7-9-16/h5-14,25-26H,4H2,1-3H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
0.810 -51.9n/an/an/an/an/a6.025



AbbVie Inc

US Patent


Assay Description
A time-resolved fluorescence resonance energy transfer (TR-FRET) assay was used to determine the affinities of compounds of the Examples listed in Ta...


US Patent US9296741 (2016)


BindingDB Entry DOI: 10.7270/Q26W98ZQ
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)(aa 57-168)


(Homo sapiens (Human))
BDBM220626
PNG
(US9296741, 215)
Show SMILES Cn1cc(-c2cc(ccc2OC2CCCCC2)S(C)(=O)=O)c2cc[nH]c2c1=O
Show InChI InChI=1S/C21H24N2O4S/c1-23-13-18(16-10-11-22-20(16)21(23)24)17-12-15(28(2,25)26)8-9-19(17)27-14-6-4-3-5-7-14/h8-14,22H,3-7H2,1-2H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
0.830 -51.8n/an/an/an/an/a6.025



AbbVie Inc

US Patent


Assay Description
A time-resolved fluorescence resonance energy transfer (TR-FRET) assay was used to determine the affinities of compounds of the Examples listed in Ta...


US Patent US9296741 (2016)


BindingDB Entry DOI: 10.7270/Q26W98ZQ
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)(aa 57-168)


(Homo sapiens (Human))
BDBM220470
PNG
(US9296741, 59)
Show SMILES Cn1cc(-c2cc(NS(C)(=O)=O)ccc2OC2CCC(F)(F)CC2)c2cc[nH]c2c1=O
Show InChI InChI=1S/C21H23F2N3O4S/c1-26-12-17(15-7-10-24-19(15)20(26)27)16-11-13(25-31(2,28)29)3-4-18(16)30-14-5-8-21(22,23)9-6-14/h3-4,7,10-12,14,24-25H,5-6,8-9H2,1-2H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
0.840 -51.8n/an/an/an/an/a6.025



AbbVie Inc

US Patent


Assay Description
A time-resolved fluorescence resonance energy transfer (TR-FRET) assay was used to determine the affinities of compounds of the Examples listed in Ta...


US Patent US9296741 (2016)


BindingDB Entry DOI: 10.7270/Q26W98ZQ
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)(aa 57-168)


(Homo sapiens (Human))
BDBM220611
PNG
(US9296741, 200)
Show SMILES CCS(=O)(=O)c1ccc(NCC2CC2)c(c1)-c1cn(C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C20H23N3O3S/c1-3-27(25,26)14-6-7-18(22-11-13-4-5-13)16(10-14)17-12-23(2)20(24)19-15(17)8-9-21-19/h6-10,12-13,21-22H,3-5,11H2,1-2H3
PDB

GoogleScholar
PC cid
PC sid
PDB
UniChem
US Patent
0.860 -51.7n/an/an/an/an/a6.025



AbbVie Inc

US Patent


Assay Description
A time-resolved fluorescence resonance energy transfer (TR-FRET) assay was used to determine the affinities of compounds of the Examples listed in Ta...


US Patent US9296741 (2016)


BindingDB Entry DOI: 10.7270/Q26W98ZQ
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)(aa 57-168)


(Homo sapiens (Human))
BDBM220749
PNG
(US9296741, 338)
Show SMILES CCS(=O)(=O)Nc1ccc(Oc2ccc(F)cc2F)c(c1)-c1cn(C)c(=O)c2[nH]c(cc12)C(=O)N1CCN(C)CC1
Show InChI InChI=1S/C28H29F2N5O5S/c1-4-41(38,39)32-18-6-8-24(40-25-7-5-17(29)13-22(25)30)19(14-18)21-16-34(3)28(37)26-20(21)15-23(31-26)27(36)35-11-9-33(2)10-12-35/h5-8,13-16,31-32H,4,9-12H2,1-3H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
0.860 -51.7n/an/an/an/an/a6.025



AbbVie Inc

US Patent


Assay Description
A time-resolved fluorescence resonance energy transfer (TR-FRET) assay was used to determine the affinities of compounds of the Examples listed in Ta...


US Patent US9296741 (2016)


BindingDB Entry DOI: 10.7270/Q26W98ZQ
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)(aa 57-168)


(Homo sapiens (Human))
BDBM220580
PNG
(US9296741, 169)
Show SMILES CCS(=O)(=O)c1ccc(OC2CCC(F)(F)CC2)c(c1)-c1cn(C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C22H24F2N2O4S/c1-3-31(28,29)15-4-5-19(30-14-6-9-22(23,24)10-7-14)17(12-15)18-13-26(2)21(27)20-16(18)8-11-25-20/h4-5,8,11-14,25H,3,6-7,9-10H2,1-2H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
0.880 -51.7n/an/an/an/an/a6.025



AbbVie Inc

US Patent


Assay Description
A time-resolved fluorescence resonance energy transfer (TR-FRET) assay was used to determine the affinities of compounds of the Examples listed in Ta...


US Patent US9296741 (2016)


BindingDB Entry DOI: 10.7270/Q26W98ZQ
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)(aa 57-168)


(Homo sapiens (Human))
BDBM220468
PNG
(US9296741, 57)
Show SMILES Cn1cc(-c2cc(NS(C)(=O)=O)ccc2OC2CCCCC2)c2cc[nH]c2c1=O
Show InChI InChI=1S/C21H25N3O4S/c1-24-13-18(16-10-11-22-20(16)21(24)25)17-12-14(23-29(2,26)27)8-9-19(17)28-15-6-4-3-5-7-15/h8-13,15,22-23H,3-7H2,1-2H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
0.880 -51.7n/an/an/an/an/a6.025



AbbVie Inc

US Patent


Assay Description
A time-resolved fluorescence resonance energy transfer (TR-FRET) assay was used to determine the affinities of compounds of the Examples listed in Ta...


US Patent US9296741 (2016)


BindingDB Entry DOI: 10.7270/Q26W98ZQ
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)(aa 57-168)


(Homo sapiens (Human))
BDBM220484
PNG
(US9296741, 73)
Show SMILES Cn1cc(-c2cc(NS(C)(=O)=O)ccc2Oc2ccccc2)c2cc([nH]c2c1=O)C(N)=O
Show InChI InChI=1S/C22H20N4O5S/c1-26-12-17(16-11-18(21(23)27)24-20(16)22(26)28)15-10-13(25-32(2,29)30)8-9-19(15)31-14-6-4-3-5-7-14/h3-12,24-25H,1-2H3,(H2,23,27)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
0.980 -51.4n/an/an/an/an/a6.025



AbbVie Inc

US Patent


Assay Description
A time-resolved fluorescence resonance energy transfer (TR-FRET) assay was used to determine the affinities of compounds of the Examples listed in Ta...


US Patent US9296741 (2016)


BindingDB Entry DOI: 10.7270/Q26W98ZQ
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)(aa 57-168)


(Homo sapiens (Human))
BDBM220671
PNG
(US9296741, 260)
Show SMILES CCS(=O)(=O)c1ccc(O[C@H]2CC[C@@H](CC2)OC)c(c1)-c1cn(C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C23H28N2O5S/c1-4-31(27,28)17-9-10-21(30-16-7-5-15(29-3)6-8-16)19(13-17)20-14-25(2)23(26)22-18(20)11-12-24-22/h9-16,24H,4-8H2,1-3H3/t15-,16-
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1 -51.4n/an/an/an/an/a6.025



AbbVie Inc

US Patent


Assay Description
A time-resolved fluorescence resonance energy transfer (TR-FRET) assay was used to determine the affinities of compounds of the Examples listed in Ta...


US Patent US9296741 (2016)


BindingDB Entry DOI: 10.7270/Q26W98ZQ
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)(aa 57-168)


(Homo sapiens (Human))
BDBM220649
PNG
(US9296741, 238)
Show SMILES Cn1cc(-c2cc(ccc2NCC2CC2)S(N)(=O)=O)c2cc[nH]c2c1=O
Show InChI InChI=1S/C18H20N4O3S/c1-22-10-15(13-6-7-20-17(13)18(22)23)14-8-12(26(19,24)25)4-5-16(14)21-9-11-2-3-11/h4-8,10-11,20-21H,2-3,9H2,1H3,(H2,19,24,25)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.10 -51.1n/an/an/an/an/a6.025



AbbVie Inc

US Patent


Assay Description
A time-resolved fluorescence resonance energy transfer (TR-FRET) assay was used to determine the affinities of compounds of the Examples listed in Ta...


US Patent US9296741 (2016)


BindingDB Entry DOI: 10.7270/Q26W98ZQ
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)(aa 57-168)


(Homo sapiens (Human))
BDBM220440
PNG
(US9296741, 29)
Show SMILES Cn1cc(-c2cc(NS(C)(=O)=O)ccc2OC2CCOCC2)c2cc[nH]c2c1=O
Show InChI InChI=1S/C20H23N3O5S/c1-23-12-17(15-5-8-21-19(15)20(23)24)16-11-13(22-29(2,25)26)3-4-18(16)28-14-6-9-27-10-7-14/h3-5,8,11-12,14,21-22H,6-7,9-10H2,1-2H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.10 -51.1n/an/an/an/an/a6.025



AbbVie Inc

US Patent


Assay Description
A time-resolved fluorescence resonance energy transfer (TR-FRET) assay was used to determine the affinities of compounds of the Examples listed in Ta...


US Patent US9296741 (2016)


BindingDB Entry DOI: 10.7270/Q26W98ZQ
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)(aa 57-168)


(Homo sapiens (Human))
BDBM220684
PNG
(US9296741, 273)
Show SMILES CN(C)S(=O)(=O)c1ccc(OCC2CC2)c(c1)-c1cn(C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C20H23N3O4S/c1-22(2)28(25,26)14-6-7-18(27-12-13-4-5-13)16(10-14)17-11-23(3)20(24)19-15(17)8-9-21-19/h6-11,13,21H,4-5,12H2,1-3H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.20 -50.9n/an/an/an/an/a6.025



AbbVie Inc

US Patent


Assay Description
A time-resolved fluorescence resonance energy transfer (TR-FRET) assay was used to determine the affinities of compounds of the Examples listed in Ta...


US Patent US9296741 (2016)


BindingDB Entry DOI: 10.7270/Q26W98ZQ
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)(aa 57-168)


(Homo sapiens (Human))
BDBM220512
PNG
(US9296741, 101)
Show SMILES CCS(=O)(=O)Nc1ccc(OC2CCC(F)(F)CC2)c(c1)-c1cn(C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C22H25F2N3O4S/c1-3-32(29,30)26-14-4-5-19(31-15-6-9-22(23,24)10-7-15)17(12-14)18-13-27(2)21(28)20-16(18)8-11-25-20/h4-5,8,11-13,15,25-26H,3,6-7,9-10H2,1-2H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.20 -50.9n/an/an/an/an/a6.025



AbbVie Inc

US Patent


Assay Description
A time-resolved fluorescence resonance energy transfer (TR-FRET) assay was used to determine the affinities of compounds of the Examples listed in Ta...


US Patent US9296741 (2016)


BindingDB Entry DOI: 10.7270/Q26W98ZQ
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)(aa 57-168)


(Homo sapiens (Human))
BDBM220675
PNG
(US9296741, 264)
Show SMILES CCS(=O)(=O)c1ccc(OC2CCSCC2)c(c1)-c1cn(C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C21H24N2O4S2/c1-3-29(25,26)15-4-5-19(27-14-7-10-28-11-8-14)17(12-15)18-13-23(2)21(24)20-16(18)6-9-22-20/h4-6,9,12-14,22H,3,7-8,10-11H2,1-2H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.20 -50.9n/an/an/an/an/a6.025



AbbVie Inc

US Patent


Assay Description
A time-resolved fluorescence resonance energy transfer (TR-FRET) assay was used to determine the affinities of compounds of the Examples listed in Ta...


US Patent US9296741 (2016)


BindingDB Entry DOI: 10.7270/Q26W98ZQ
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)(aa 57-168)


(Homo sapiens (Human))
BDBM220434
PNG
(US9296741, 23)
Show SMILES Cn1cc(-c2cc(NS(C)(=O)=O)cnc2Oc2ccccc2)c2cc[nH]c2c1=O
Show InChI InChI=1S/C20H18N4O4S/c1-24-12-17(15-8-9-21-18(15)20(24)25)16-10-13(23-29(2,26)27)11-22-19(16)28-14-6-4-3-5-7-14/h3-12,21,23H,1-2H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.20 -50.9n/an/an/an/an/a6.025



AbbVie Inc

US Patent


Assay Description
A time-resolved fluorescence resonance energy transfer (TR-FRET) assay was used to determine the affinities of compounds of the Examples listed in Ta...


US Patent US9296741 (2016)


BindingDB Entry DOI: 10.7270/Q26W98ZQ
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)(aa 57-168)


(Homo sapiens (Human))
BDBM220517
PNG
(US9296741, 106)
Show SMILES CCCS(=O)(=O)Nc1ccc(OC2CCCOC2)c(c1)-c1cn(C)c(=O)c2[nH]ccc12
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.30 -50.7n/an/an/an/an/a6.025



AbbVie Inc

US Patent


Assay Description
A time-resolved fluorescence resonance energy transfer (TR-FRET) assay was used to determine the affinities of compounds of the Examples listed in Ta...


US Patent US9296741 (2016)


BindingDB Entry DOI: 10.7270/Q26W98ZQ
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)(aa 57-168)


(Homo sapiens (Human))
BDBM220609
PNG
(US9296741, 198)
Show SMILES CCS(=O)(=O)c1ccc(OCC2CC2)c(c1)-c1cn(C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C20H22N2O4S/c1-3-27(24,25)14-6-7-18(26-12-13-4-5-13)16(10-14)17-11-22(2)20(23)19-15(17)8-9-21-19/h6-11,13,21H,3-5,12H2,1-2H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.30 -50.7n/an/an/an/an/a6.025



AbbVie Inc

US Patent


Assay Description
A time-resolved fluorescence resonance energy transfer (TR-FRET) assay was used to determine the affinities of compounds of the Examples listed in Ta...


US Patent US9296741 (2016)


BindingDB Entry DOI: 10.7270/Q26W98ZQ
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)(aa 57-168)


(Homo sapiens (Human))
BDBM220519
PNG
(US9296741, 108)
Show SMILES CNS(=O)(=O)Nc1ccc(OC2CCCOC2)c(c1)-c1cn(C)c(=O)c2[nH]ccc12
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.40 -50.5n/an/an/an/an/a6.025



AbbVie Inc

US Patent


Assay Description
A time-resolved fluorescence resonance energy transfer (TR-FRET) assay was used to determine the affinities of compounds of the Examples listed in Ta...


US Patent US9296741 (2016)


BindingDB Entry DOI: 10.7270/Q26W98ZQ
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)(aa 57-168)


(Homo sapiens (Human))
BDBM220415
PNG
(US9296741, 4)
Show SMILES Cn1cc(-c2cc(NS(C)(=O)=O)ccc2Oc2ccccc2)c2cc[nH]c2c1=O
Show InChI InChI=1S/C21H19N3O4S/c1-24-13-18(16-10-11-22-20(16)21(24)25)17-12-14(23-29(2,26)27)8-9-19(17)28-15-6-4-3-5-7-15/h3-13,22-23H,1-2H3
PDB

GoogleScholar
PC cid
PC sid
PDB
UniChem
US Patent
1.40 -50.5n/an/an/an/an/a6.025



AbbVie Inc

US Patent


Assay Description
A time-resolved fluorescence resonance energy transfer (TR-FRET) assay was used to determine the affinities of compounds of the Examples listed in Ta...


US Patent US9296741 (2016)


BindingDB Entry DOI: 10.7270/Q26W98ZQ
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)(aa 57-168)


(Homo sapiens (Human))
BDBM220511
PNG
(US9296741, 100)
Show SMILES Cn1cc(-c2cc(NS(=O)(=O)CC(F)(F)F)ccc2OC2CCOCC2)c2cc[nH]c2c1=O
Show InChI InChI=1S/C21H22F3N3O5S/c1-27-11-17(15-4-7-25-19(15)20(27)28)16-10-13(26-33(29,30)12-21(22,23)24)2-3-18(16)32-14-5-8-31-9-6-14/h2-4,7,10-11,14,25-26H,5-6,8-9,12H2,1H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.40 -50.5n/an/an/an/an/a6.025



AbbVie Inc

US Patent


Assay Description
A time-resolved fluorescence resonance energy transfer (TR-FRET) assay was used to determine the affinities of compounds of the Examples listed in Ta...


US Patent US9296741 (2016)


BindingDB Entry DOI: 10.7270/Q26W98ZQ
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)(aa 57-168)


(Homo sapiens (Human))
BDBM220622
PNG
(US9296741, 211 | US9296741, 212)
Show SMILES CCS(=O)(=O)c1ccc(OC2CCC(C)(O)CC2)c(c1)-c1cn(C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C23H28N2O5S/c1-4-31(28,29)16-5-6-20(30-15-7-10-23(2,27)11-8-15)18(13-16)19-14-25(3)22(26)21-17(19)9-12-24-21/h5-6,9,12-15,24,27H,4,7-8,10-11H2,1-3H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.40 -50.5n/an/an/an/an/a6.025



AbbVie Inc

US Patent


Assay Description
A time-resolved fluorescence resonance energy transfer (TR-FRET) assay was used to determine the affinities of compounds of the Examples listed in Ta...


US Patent US9296741 (2016)


BindingDB Entry DOI: 10.7270/Q26W98ZQ
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)(aa 57-168)


(Homo sapiens (Human))
BDBM220672
PNG
(US9296741, 261)
Show SMILES CC(C)S(=O)(=O)c1ccc(NCC2CC2)c(c1)-c1cn(C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C21H25N3O3S/c1-13(2)28(26,27)15-6-7-19(23-11-14-4-5-14)17(10-15)18-12-24(3)21(25)20-16(18)8-9-22-20/h6-10,12-14,22-23H,4-5,11H2,1-3H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.5 -50.4n/an/an/an/an/a6.025



AbbVie Inc

US Patent


Assay Description
A time-resolved fluorescence resonance energy transfer (TR-FRET) assay was used to determine the affinities of compounds of the Examples listed in Ta...


US Patent US9296741 (2016)


BindingDB Entry DOI: 10.7270/Q26W98ZQ
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)(aa 57-168)


(Homo sapiens (Human))
BDBM220661
PNG
(US9296741, 250)
Show SMILES CNS(=O)(=O)c1ccc(OCC2CC2)c(c1)-c1cn(C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C19H21N3O4S/c1-20-27(24,25)13-5-6-17(26-11-12-3-4-12)15(9-13)16-10-22(2)19(23)18-14(16)7-8-21-18/h5-10,12,20-21H,3-4,11H2,1-2H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.5 -50.4n/an/an/an/an/a6.025



AbbVie Inc

US Patent


Assay Description
A time-resolved fluorescence resonance energy transfer (TR-FRET) assay was used to determine the affinities of compounds of the Examples listed in Ta...


US Patent US9296741 (2016)


BindingDB Entry DOI: 10.7270/Q26W98ZQ
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)(aa 57-168)


(Homo sapiens (Human))
BDBM220483
PNG
(US9296741, 72)
Show SMILES CCNC(=O)c1cc2c(cn(C)c(=O)c2[nH]1)-c1cc(NS(C)(=O)=O)ccc1Oc1ccccc1
Show InChI InChI=1S/C24H24N4O5S/c1-4-25-23(29)20-13-18-19(14-28(2)24(30)22(18)26-20)17-12-15(27-34(3,31)32)10-11-21(17)33-16-8-6-5-7-9-16/h5-14,26-27H,4H2,1-3H3,(H,25,29)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.5 -50.4n/an/an/an/an/a6.025



AbbVie Inc

US Patent


Assay Description
A time-resolved fluorescence resonance energy transfer (TR-FRET) assay was used to determine the affinities of compounds of the Examples listed in Ta...


US Patent US9296741 (2016)


BindingDB Entry DOI: 10.7270/Q26W98ZQ
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)(aa 57-168)


(Homo sapiens (Human))
BDBM220608
PNG
(US9296741, 197)
Show SMILES CCS(=O)(=O)c1ccc(OC2CCC3(CC2)OCCO3)c(c1)-c1cn(C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C24H28N2O6S/c1-3-33(28,29)17-4-5-21(32-16-6-9-24(10-7-16)30-12-13-31-24)19(14-17)20-15-26(2)23(27)22-18(20)8-11-25-22/h4-5,8,11,14-16,25H,3,6-7,9-10,12-13H2,1-2H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.5 -50.4n/an/an/an/an/a6.025



AbbVie Inc

US Patent


Assay Description
A time-resolved fluorescence resonance energy transfer (TR-FRET) assay was used to determine the affinities of compounds of the Examples listed in Ta...


US Patent US9296741 (2016)


BindingDB Entry DOI: 10.7270/Q26W98ZQ
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)(aa 57-168)


(Homo sapiens (Human))
BDBM220660
PNG
(US9296741, 249)
Show SMILES Cn1cc(-c2cc(ccc2OCC2CC2)S(N)(=O)=O)c2cc[nH]c2c1=O
Show InChI InChI=1S/C18H19N3O4S/c1-21-9-15(13-6-7-20-17(13)18(21)22)14-8-12(26(19,23)24)4-5-16(14)25-10-11-2-3-11/h4-9,11,20H,2-3,10H2,1H3,(H2,19,23,24)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.5 -50.4n/an/an/an/an/a6.025



AbbVie Inc

US Patent


Assay Description
A time-resolved fluorescence resonance energy transfer (TR-FRET) assay was used to determine the affinities of compounds of the Examples listed in Ta...


US Patent US9296741 (2016)


BindingDB Entry DOI: 10.7270/Q26W98ZQ
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)(aa 57-168)


(Homo sapiens (Human))
BDBM220500
PNG
(US9296741, 89)
Show SMILES Cn1cc(-c2cc(NS(C)(=O)=O)ccc2Oc2ccccc2)c2cc(CO)[nH]c2c1=O
Show InChI InChI=1S/C22H21N3O5S/c1-25-12-19(18-11-15(13-26)23-21(18)22(25)27)17-10-14(24-31(2,28)29)8-9-20(17)30-16-6-4-3-5-7-16/h3-12,23-24,26H,13H2,1-2H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.60 -50.2n/an/an/an/an/a6.025



AbbVie Inc

US Patent


Assay Description
A time-resolved fluorescence resonance energy transfer (TR-FRET) assay was used to determine the affinities of compounds of the Examples listed in Ta...


US Patent US9296741 (2016)


BindingDB Entry DOI: 10.7270/Q26W98ZQ
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)(aa 57-168)


(Homo sapiens (Human))
BDBM220495
PNG
(US9296741, 84)
Show SMILES CCS(=O)(=O)Nc1ccc(Oc2ccc(cc2)C(N)=O)c(c1)-c1cn(C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C23H22N4O5S/c1-3-33(30,31)26-15-6-9-20(32-16-7-4-14(5-8-16)22(24)28)18(12-15)19-13-27(2)23(29)21-17(19)10-11-25-21/h4-13,25-26H,3H2,1-2H3,(H2,24,28)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.67 -50.1n/an/an/an/an/a6.025



AbbVie Inc

US Patent


Assay Description
A time-resolved fluorescence resonance energy transfer (TR-FRET) assay was used to determine the affinities of compounds of the Examples listed in Ta...


US Patent US9296741 (2016)


BindingDB Entry DOI: 10.7270/Q26W98ZQ
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)(aa 57-168)


(Homo sapiens (Human))
BDBM220460
PNG
(US9296741, 49)
Show SMILES Cn1cc(-c2cc(NS(C)(=O)=O)ccc2Oc2c(F)cc(F)cc2F)c2cc[nH]c2c1=O
Show InChI InChI=1S/C21H16F3N3O4S/c1-27-10-15(13-5-6-25-19(13)21(27)28)14-9-12(26-32(2,29)30)3-4-18(14)31-20-16(23)7-11(22)8-17(20)24/h3-10,25-26H,1-2H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.70 -50.1n/an/an/an/an/a6.025



AbbVie Inc

US Patent


Assay Description
A time-resolved fluorescence resonance energy transfer (TR-FRET) assay was used to determine the affinities of compounds of the Examples listed in Ta...


US Patent US9296741 (2016)


BindingDB Entry DOI: 10.7270/Q26W98ZQ
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)(aa 57-168)


(Homo sapiens (Human))
BDBM220613
PNG
(US9296741, 202)
Show SMILES CCS(=O)(=O)c1ccc(O[C@@H]2CC[C@H](O)CC2)c(c1)-c1cn(C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C22H26N2O5S/c1-3-30(27,28)16-8-9-20(29-15-6-4-14(25)5-7-15)18(12-16)19-13-24(2)22(26)21-17(19)10-11-23-21/h8-15,23,25H,3-7H2,1-2H3/t14-,15+
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.70 -50.1n/an/an/an/an/a6.025



AbbVie Inc

US Patent


Assay Description
A time-resolved fluorescence resonance energy transfer (TR-FRET) assay was used to determine the affinities of compounds of the Examples listed in Ta...


US Patent US9296741 (2016)


BindingDB Entry DOI: 10.7270/Q26W98ZQ
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)(aa 57-168)


(Homo sapiens (Human))
BDBM220454
PNG
(US9296741, 43)
Show SMILES Cn1cc(-c2cc(ccc2Oc2ccc(F)cc2F)N2CCCS2(=O)=O)c2cc[nH]c2c1=O
Show InChI InChI=1S/C23H19F2N3O4S/c1-27-13-18(16-7-8-26-22(16)23(27)29)17-12-15(28-9-2-10-33(28,30)31)4-6-20(17)32-21-5-3-14(24)11-19(21)25/h3-8,11-13,26H,2,9-10H2,1H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.70 -50.1n/an/an/an/an/a6.025



AbbVie Inc

US Patent


Assay Description
A time-resolved fluorescence resonance energy transfer (TR-FRET) assay was used to determine the affinities of compounds of the Examples listed in Ta...


US Patent US9296741 (2016)


BindingDB Entry DOI: 10.7270/Q26W98ZQ
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)(aa 57-168)


(Homo sapiens (Human))
BDBM220439
PNG
(US9296741, 28)
Show SMILES Cn1cc(-c2cc(NS(C)(=O)=O)cc(Cl)c2Oc2ccccc2)c2cc[nH]c2c1=O
Show InChI InChI=1S/C21H18ClN3O4S/c1-25-12-17(15-8-9-23-19(15)21(25)26)16-10-13(24-30(2,27)28)11-18(22)20(16)29-14-6-4-3-5-7-14/h3-12,23-24H,1-2H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.70 -50.1n/an/an/an/an/a6.025



AbbVie Inc

US Patent


Assay Description
A time-resolved fluorescence resonance energy transfer (TR-FRET) assay was used to determine the affinities of compounds of the Examples listed in Ta...


US Patent US9296741 (2016)


BindingDB Entry DOI: 10.7270/Q26W98ZQ
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)(aa 57-168)


(Homo sapiens (Human))
BDBM220442
PNG
(US9296741, 31)
Show SMILES Cn1cc(-c2cc(NS(C)(=O)=O)ccc2OC2CCOC2)c2cc[nH]c2c1=O
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.80 -49.9n/an/an/an/an/a6.025



AbbVie Inc

US Patent


Assay Description
A time-resolved fluorescence resonance energy transfer (TR-FRET) assay was used to determine the affinities of compounds of the Examples listed in Ta...


US Patent US9296741 (2016)


BindingDB Entry DOI: 10.7270/Q26W98ZQ
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)(aa 57-168)


(Homo sapiens (Human))
BDBM220692
PNG
(US9296741, 281)
Show SMILES CN1CCN(Cc2cc3c(cn(C)c(=O)c3[nH]2)-c2cc(ccc2Oc2ccc(F)cc2F)S(C)(=O)=O)CC1
Show InChI InChI=1S/C27H28F2N4O4S/c1-31-8-10-33(11-9-31)15-18-13-21-22(16-32(2)27(34)26(21)30-18)20-14-19(38(3,35)36)5-7-24(20)37-25-6-4-17(28)12-23(25)29/h4-7,12-14,16,30H,8-11,15H2,1-3H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.80 -49.9n/an/an/an/an/a6.025



AbbVie Inc

US Patent


Assay Description
A time-resolved fluorescence resonance energy transfer (TR-FRET) assay was used to determine the affinities of compounds of the Examples listed in Ta...


US Patent US9296741 (2016)


BindingDB Entry DOI: 10.7270/Q26W98ZQ
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)(aa 57-168)


(Homo sapiens (Human))
BDBM220627
PNG
(US9296741, 216)
Show SMILES Cn1cc(-c2cc(ccc2OC2CCCC2)S(C)(=O)=O)c2cc[nH]c2c1=O
Show InChI InChI=1S/C20H22N2O4S/c1-22-12-17(15-9-10-21-19(15)20(22)23)16-11-14(27(2,24)25)7-8-18(16)26-13-5-3-4-6-13/h7-13,21H,3-6H2,1-2H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.80 -49.9n/an/an/an/an/a6.025



AbbVie Inc

US Patent


Assay Description
A time-resolved fluorescence resonance energy transfer (TR-FRET) assay was used to determine the affinities of compounds of the Examples listed in Ta...


US Patent US9296741 (2016)


BindingDB Entry DOI: 10.7270/Q26W98ZQ
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)(aa 57-168)


(Homo sapiens (Human))
BDBM220622
PNG
(US9296741, 211 | US9296741, 212)
Show SMILES CCS(=O)(=O)c1ccc(OC2CCC(C)(O)CC2)c(c1)-c1cn(C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C23H28N2O5S/c1-4-31(28,29)16-5-6-20(30-15-7-10-23(2,27)11-8-15)18(13-16)19-14-25(3)22(26)21-17(19)9-12-24-21/h5-6,9,12-15,24,27H,4,7-8,10-11H2,1-3H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.80 -49.9n/an/an/an/an/a6.025



AbbVie Inc

US Patent


Assay Description
A time-resolved fluorescence resonance energy transfer (TR-FRET) assay was used to determine the affinities of compounds of the Examples listed in Ta...


US Patent US9296741 (2016)


BindingDB Entry DOI: 10.7270/Q26W98ZQ
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)(aa 57-168)


(Homo sapiens (Human))
BDBM220422
PNG
(US9296741, 11)
Show SMILES Cn1cc(-c2cc(NS(C)(=O)=O)ccc2Oc2cccnc2)c2cc[nH]c2c1=O
Show InChI InChI=1S/C20H18N4O4S/c1-24-12-17(15-7-9-22-19(15)20(24)25)16-10-13(23-29(2,26)27)5-6-18(16)28-14-4-3-8-21-11-14/h3-12,22-23H,1-2H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.80 -49.9n/an/an/an/an/a6.025



AbbVie Inc

US Patent


Assay Description
A time-resolved fluorescence resonance energy transfer (TR-FRET) assay was used to determine the affinities of compounds of the Examples listed in Ta...


US Patent US9296741 (2016)


BindingDB Entry DOI: 10.7270/Q26W98ZQ
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)(aa 57-168)


(Homo sapiens (Human))
BDBM220514
PNG
(US9296741, 103)
Show SMILES Cn1cc(-c2cc(NS(=O)(=O)CC(F)(F)F)ccc2OC2CCC(F)(F)CC2)c2cc[nH]c2c1=O
Show InChI InChI=1S/C22H22F5N3O4S/c1-30-11-17(15-6-9-28-19(15)20(30)31)16-10-13(29-35(32,33)12-22(25,26)27)2-3-18(16)34-14-4-7-21(23,24)8-5-14/h2-3,6,9-11,14,28-29H,4-5,7-8,12H2,1H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.90 -49.8n/an/an/an/an/a6.025



AbbVie Inc

US Patent


Assay Description
A time-resolved fluorescence resonance energy transfer (TR-FRET) assay was used to determine the affinities of compounds of the Examples listed in Ta...


US Patent US9296741 (2016)


BindingDB Entry DOI: 10.7270/Q26W98ZQ
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)(aa 57-168)


(Homo sapiens (Human))
BDBM220610
PNG
(US9296741, 199)
Show SMILES CCS(=O)(=O)c1ccc(OC2CCC(=O)CC2)c(c1)-c1cn(C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C22H24N2O5S/c1-3-30(27,28)16-8-9-20(29-15-6-4-14(25)5-7-15)18(12-16)19-13-24(2)22(26)21-17(19)10-11-23-21/h8-13,15,23H,3-7H2,1-2H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.90 -49.8n/an/an/an/an/a6.025



AbbVie Inc

US Patent


Assay Description
A time-resolved fluorescence resonance energy transfer (TR-FRET) assay was used to determine the affinities of compounds of the Examples listed in Ta...


US Patent US9296741 (2016)


BindingDB Entry DOI: 10.7270/Q26W98ZQ
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)(aa 57-168)


(Homo sapiens (Human))
BDBM220659
PNG
(US9296741, 248)
Show SMILES CCS(=O)(=O)c1ccc(O[C@@H]2CC[C@@H](CC2)OC)c(c1)-c1cn(C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C23H28N2O5S/c1-4-31(27,28)17-9-10-21(30-16-7-5-15(29-3)6-8-16)19(13-17)20-14-25(2)23(26)22-18(20)11-12-24-22/h9-16,24H,4-8H2,1-3H3/t15-,16+
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.90 -49.8n/an/an/an/an/a6.025



AbbVie Inc

US Patent


Assay Description
A time-resolved fluorescence resonance energy transfer (TR-FRET) assay was used to determine the affinities of compounds of the Examples listed in Ta...


US Patent US9296741 (2016)


BindingDB Entry DOI: 10.7270/Q26W98ZQ
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 585 total )  |  Next  |  Last  >>
Jump to: