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Found 2946 hits Enz. Inhib. hit(s) with Target = 'Casein kinase I delta/epsilon'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM274782
PNG
(N-(6-(4-(4-fluorophenyl)-1,2- dimethyl-1H-imidazol...)
Show SMILES Cc1nc(c(-c2ccc3nc(NC(=O)c4ccc[nH]4)cn3n2)n1C)-c1ccc(F)cc1
Show InChI InChI=1S/C22H18FN7O/c1-13-25-20(14-5-7-15(23)8-6-14)21(29(13)2)16-9-10-19-26-18(12-30(19)28-16)27-22(31)17-4-3-11-24-17/h3-12,24H,1-2H3,(H,27,31)
PDB

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UniChem
US Patent
n/an/a 0.534n/an/an/an/a7.425



Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)

More data for this
Ligand-Target Pair
Casein kinase I Epsilon


(Homo sapiens (Human))
BDBM274783
PNG
(N-(6-(4-(4-fluorophenyl)-1,2- dimethyl-1H-imidazol...)
Show SMILES Cc1nc(c(-c2ccc3nc(NC(=O)c4cnn(C)c4)cn3n2)n1C)-c1ccc(F)cc1
Show InChI InChI=1S/C22H19FN8O/c1-13-25-20(14-4-6-16(23)7-5-14)21(30(13)3)17-8-9-19-26-18(12-31(19)28-17)27-22(32)15-10-24-29(2)11-15/h4-12H,1-3H3,(H,27,32)
PDB

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UniChem
US Patent
n/an/a 3.17n/an/an/an/a7.425



Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)

More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM274783
PNG
(N-(6-(4-(4-fluorophenyl)-1,2- dimethyl-1H-imidazol...)
Show SMILES Cc1nc(c(-c2ccc3nc(NC(=O)c4cnn(C)c4)cn3n2)n1C)-c1ccc(F)cc1
Show InChI InChI=1S/C22H19FN8O/c1-13-25-20(14-4-6-16(23)7-5-14)21(30(13)3)17-8-9-19-26-18(12-31(19)28-17)27-22(32)15-10-24-29(2)11-15/h4-12H,1-3H3,(H,27,32)
PDB

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UniChem
US Patent
n/an/a 0.599n/an/an/an/a7.425



Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)

More data for this
Ligand-Target Pair
Casein kinase I Epsilon


(Homo sapiens (Human))
BDBM274784
PNG
(N-(6-(4-(4-fluorophenyl)-1,2- dimethyl-1H-imidazol...)
Show SMILES Cc1nc(c(-c2ccc3nc(NC(=O)c4cncn4C)cn3n2)n1C)-c1ccc(F)cc1
Show InChI InChI=1S/C22H19FN8O/c1-13-25-20(14-4-6-15(23)7-5-14)21(30(13)3)16-8-9-19-26-18(11-31(19)28-16)27-22(32)17-10-24-12-29(17)2/h4-12H,1-3H3,(H,27,32)
PDB

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US Patent
n/an/a 5.38n/an/an/an/a7.425



Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)

More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM274784
PNG
(N-(6-(4-(4-fluorophenyl)-1,2- dimethyl-1H-imidazol...)
Show SMILES Cc1nc(c(-c2ccc3nc(NC(=O)c4cncn4C)cn3n2)n1C)-c1ccc(F)cc1
Show InChI InChI=1S/C22H19FN8O/c1-13-25-20(14-4-6-15(23)7-5-14)21(30(13)3)16-8-9-19-26-18(11-31(19)28-16)27-22(32)17-10-24-12-29(17)2/h4-12H,1-3H3,(H,27,32)
PDB

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UniChem
US Patent
n/an/a 0.520n/an/an/an/a7.425



Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)

More data for this
Ligand-Target Pair
Casein kinase I Epsilon


(Homo sapiens (Human))
BDBM274785
PNG
(N-(6-(4-(4-fluorophenyl)-1,2- dimethyl-1H-imidazol...)
Show SMILES Cc1nocc1C(=O)Nc1cn2nc(ccc2n1)-c1c(nc(C)n1C)-c1ccc(F)cc1
Show InChI InChI=1S/C22H18FN7O2/c1-12-16(11-32-28-12)22(31)26-18-10-30-19(25-18)9-8-17(27-30)21-20(24-13(2)29(21)3)14-4-6-15(23)7-5-14/h4-11H,1-3H3,(H,26,31)
PDB

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n/an/a 1.26E+3n/an/an/an/a7.425



Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)

More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM274785
PNG
(N-(6-(4-(4-fluorophenyl)-1,2- dimethyl-1H-imidazol...)
Show SMILES Cc1nocc1C(=O)Nc1cn2nc(ccc2n1)-c1c(nc(C)n1C)-c1ccc(F)cc1
Show InChI InChI=1S/C22H18FN7O2/c1-12-16(11-32-28-12)22(31)26-18-10-30-19(25-18)9-8-17(27-30)21-20(24-13(2)29(21)3)14-4-6-15(23)7-5-14/h4-11H,1-3H3,(H,26,31)
PDB

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US Patent
n/an/a 74.8n/an/an/an/a7.425



Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)

More data for this
Ligand-Target Pair
Casein kinase I Epsilon


(Homo sapiens (Human))
BDBM274786
PNG
(N-(6-(4-(4-fluorophenyl)-1,2- dimethyl-1H-imidazol...)
Show SMILES Cc1nc(c(-c2ccc3nc(NC(=O)c4cn(C)cn4)cn3n2)n1C)-c1ccc(F)cc1
Show InChI InChI=1S/C22H19FN8O/c1-13-25-20(14-4-6-15(23)7-5-14)21(30(13)3)16-8-9-19-26-18(11-31(19)28-16)27-22(32)17-10-29(2)12-24-17/h4-12H,1-3H3,(H,27,32)
PDB

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n/an/a 87.5n/an/an/an/a7.425



Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)

More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM274786
PNG
(N-(6-(4-(4-fluorophenyl)-1,2- dimethyl-1H-imidazol...)
Show SMILES Cc1nc(c(-c2ccc3nc(NC(=O)c4cn(C)cn4)cn3n2)n1C)-c1ccc(F)cc1
Show InChI InChI=1S/C22H19FN8O/c1-13-25-20(14-4-6-15(23)7-5-14)21(30(13)3)16-8-9-19-26-18(11-31(19)28-16)27-22(32)17-10-29(2)12-24-17/h4-12H,1-3H3,(H,27,32)
PDB

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UniChem
US Patent
n/an/a 6.34n/an/an/an/a7.425



Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)

More data for this
Ligand-Target Pair
Casein kinase I Epsilon


(Homo sapiens (Human))
BDBM274777
PNG
(1-acetyl-N-(6-(4-(4-fluoro- phenyl)-1,2-dimethyl-1...)
Show SMILES CC(=O)N1CCCC1C(=O)Nc1cn2nc(ccc2n1)-c1c(nc(C)n1C)-c1ccc(F)cc1
Show InChI InChI=1S/C24H24FN7O2/c1-14-26-22(16-6-8-17(25)9-7-16)23(30(14)3)18-10-11-21-27-20(13-32(21)29-18)28-24(34)19-5-4-12-31(19)15(2)33/h6-11,13,19H,4-5,12H2,1-3H3,(H,28,34)
PDB

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US Patent
n/an/a 26.2n/an/an/an/a7.425



Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)

More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM274777
PNG
(1-acetyl-N-(6-(4-(4-fluoro- phenyl)-1,2-dimethyl-1...)
Show SMILES CC(=O)N1CCCC1C(=O)Nc1cn2nc(ccc2n1)-c1c(nc(C)n1C)-c1ccc(F)cc1
Show InChI InChI=1S/C24H24FN7O2/c1-14-26-22(16-6-8-17(25)9-7-16)23(30(14)3)18-10-11-21-27-20(13-32(21)29-18)28-24(34)19-5-4-12-31(19)15(2)33/h6-11,13,19H,4-5,12H2,1-3H3,(H,28,34)
PDB

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UniChem
US Patent
n/an/a 2.36n/an/an/an/a7.425



Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)

More data for this
Ligand-Target Pair
Casein kinase I Epsilon


(Homo sapiens (Human))
BDBM274788
PNG
(N-(6-(4-(4-fluorophenyl)-1,2- dimethyl-1H-imidazol...)
Show SMILES Cc1nc(c(-c2ccc3nc(NC(=O)c4cn[nH]c4)cn3n2)n1C)-c1ccc(F)cc1
Show InChI InChI=1S/C21H17FN8O/c1-12-25-19(13-3-5-15(22)6-4-13)20(29(12)2)16-7-8-18-26-17(11-30(18)28-16)27-21(31)14-9-23-24-10-14/h3-11H,1-2H3,(H,23,24)(H,27,31)
PDB

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US Patent
n/an/a 4.01n/an/an/an/a7.425



Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)

More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM274788
PNG
(N-(6-(4-(4-fluorophenyl)-1,2- dimethyl-1H-imidazol...)
Show SMILES Cc1nc(c(-c2ccc3nc(NC(=O)c4cn[nH]c4)cn3n2)n1C)-c1ccc(F)cc1
Show InChI InChI=1S/C21H17FN8O/c1-12-25-19(13-3-5-15(22)6-4-13)20(29(12)2)16-7-8-18-26-17(11-30(18)28-16)27-21(31)14-9-23-24-10-14/h3-11H,1-2H3,(H,23,24)(H,27,31)
PDB

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n/an/a 0.566n/an/an/an/a7.425



Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)

More data for this
Ligand-Target Pair
Casein kinase I Epsilon


(Homo sapiens (Human))
BDBM274789
PNG
(N-(6-(4-(4-fluorophenyl)-1,2- dimethyl-1H-imidazol...)
Show SMILES Cc1nc(c(-c2ccc3nc(NC(=O)c4cnoc4C)cn3n2)n1C)-c1ccc(F)cc1
Show InChI InChI=1S/C22H18FN7O2/c1-12-16(10-24-32-12)22(31)27-18-11-30-19(26-18)9-8-17(28-30)21-20(25-13(2)29(21)3)14-4-6-15(23)7-5-14/h4-11H,1-3H3,(H,27,31)
PDB

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UniChem
US Patent
n/an/a 1.11E+3n/an/an/an/a7.425



Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)

More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM274789
PNG
(N-(6-(4-(4-fluorophenyl)-1,2- dimethyl-1H-imidazol...)
Show SMILES Cc1nc(c(-c2ccc3nc(NC(=O)c4cnoc4C)cn3n2)n1C)-c1ccc(F)cc1
Show InChI InChI=1S/C22H18FN7O2/c1-12-16(10-24-32-12)22(31)27-18-11-30-19(26-18)9-8-17(28-30)21-20(25-13(2)29(21)3)14-4-6-15(23)7-5-14/h4-11H,1-3H3,(H,27,31)
PDB

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n/an/a 103n/an/an/an/a7.425



Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)

More data for this
Ligand-Target Pair
Casein kinase I Epsilon


(Homo sapiens (Human))
BDBM274790
PNG
(N-(6-(4-(4-fluorophenyl)-1,2- dimethyl-1H-imidazol...)
Show SMILES Cc1nc(c(-c2ccc3nc(NC(=O)C4CCC(=O)N4)cn3n2)n1C)-c1ccc(F)cc1
Show InChI InChI=1S/C22H20FN7O2/c1-12-24-20(13-3-5-14(23)6-4-13)21(29(12)2)15-7-9-18-26-17(11-30(18)28-15)27-22(32)16-8-10-19(31)25-16/h3-7,9,11,16H,8,10H2,1-2H3,(H,25,31)(H,27,32)
PDB

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n/an/a 25.1n/an/an/an/a7.425



Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)

More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM274790
PNG
(N-(6-(4-(4-fluorophenyl)-1,2- dimethyl-1H-imidazol...)
Show SMILES Cc1nc(c(-c2ccc3nc(NC(=O)C4CCC(=O)N4)cn3n2)n1C)-c1ccc(F)cc1
Show InChI InChI=1S/C22H20FN7O2/c1-12-24-20(13-3-5-14(23)6-4-13)21(29(12)2)15-7-9-18-26-17(11-30(18)28-15)27-22(32)16-8-10-19(31)25-16/h3-7,9,11,16H,8,10H2,1-2H3,(H,25,31)(H,27,32)
PDB

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n/an/a 1.72n/an/an/an/a7.425



Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)

More data for this
Ligand-Target Pair
Casein kinase I Epsilon


(Homo sapiens (Human))
BDBM274791
PNG
(N-(6-(4-(4-fluorophenyl)-1,2- dimethyl-1H-imidazol...)
Show SMILES Cc1nnc(o1)C(=O)Nc1cn2nc(ccc2n1)-c1c(nc(C)n1C)-c1ccc(F)cc1
Show InChI InChI=1S/C21H17FN8O2/c1-11-23-18(13-4-6-14(22)7-5-13)19(29(11)3)15-8-9-17-24-16(10-30(17)28-15)25-20(31)21-27-26-12(2)32-21/h4-10H,1-3H3,(H,25,31)
PDB

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n/an/a 49.7n/an/an/an/a7.425



Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)

More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM274791
PNG
(N-(6-(4-(4-fluorophenyl)-1,2- dimethyl-1H-imidazol...)
Show SMILES Cc1nnc(o1)C(=O)Nc1cn2nc(ccc2n1)-c1c(nc(C)n1C)-c1ccc(F)cc1
Show InChI InChI=1S/C21H17FN8O2/c1-11-23-18(13-4-6-14(22)7-5-13)19(29(11)3)15-8-9-17-24-16(10-30(17)28-15)25-20(31)21-27-26-12(2)32-21/h4-10H,1-3H3,(H,25,31)
PDB

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n/an/a 3.65n/an/an/an/a7.425



Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)

More data for this
Ligand-Target Pair
Casein kinase I Epsilon


(Homo sapiens (Human))
BDBM274792
PNG
(N-(6-(4-(4-fluorophenyl)-1,2- dimethyl-1H-imidazol...)
Show SMILES Cc1nc(c(-c2ccc3nc(NC(=O)c4nc[nH]n4)cn3n2)n1C)-c1ccc(F)cc1
Show InChI InChI=1S/C20H16FN9O/c1-11-24-17(12-3-5-13(21)6-4-12)18(29(11)2)14-7-8-16-25-15(9-30(16)28-14)26-20(31)19-22-10-23-27-19/h3-10H,1-2H3,(H,26,31)(H,22,23,27)
PDB

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n/an/a 48.4n/an/an/an/a7.425



Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)

More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM274792
PNG
(N-(6-(4-(4-fluorophenyl)-1,2- dimethyl-1H-imidazol...)
Show SMILES Cc1nc(c(-c2ccc3nc(NC(=O)c4nc[nH]n4)cn3n2)n1C)-c1ccc(F)cc1
Show InChI InChI=1S/C20H16FN9O/c1-11-24-17(12-3-5-13(21)6-4-12)18(29(11)2)14-7-8-16-25-15(9-30(16)28-14)26-20(31)19-22-10-23-27-19/h3-10H,1-2H3,(H,26,31)(H,22,23,27)
PDB

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UniChem
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n/an/a 4.86n/an/an/an/a7.425



Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)

More data for this
Ligand-Target Pair
Casein kinase I Epsilon


(Homo sapiens (Human))
BDBM274793
PNG
(N-(6-(4-(4-fluorophenyl)-1,2- dimethyl-1H-imidazol...)
Show SMILES Cc1cc(nn1C)C(=O)Nc1cn2nc(ccc2n1)-c1c(nc(C)n1C)-c1ccc(F)cc1
Show InChI InChI=1S/C23H21FN8O/c1-13-11-18(28-31(13)4)23(33)27-19-12-32-20(26-19)10-9-17(29-32)22-21(25-14(2)30(22)3)15-5-7-16(24)8-6-15/h5-12H,1-4H3,(H,27,33)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)

More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM274750
PNG
(N-(6-(4-(4-fluorophenyl)-1,2- dimethyl-1H-imidazol...)
Show SMILES Cc1cc[nH]c1C(=O)Nc1cn2nc(ccc2n1)-c1c(nc(C)n1C)-c1ccc(F)cc1
Show InChI InChI=1S/C23H20FN7O/c1-13-10-11-25-20(13)23(32)28-18-12-31-19(27-18)9-8-17(29-31)22-21(26-14(2)30(22)3)15-4-6-16(24)7-5-15/h4-12,25H,1-3H3,(H,28,32)
PDB

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Bristol-Myers Squibb Company

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Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)

More data for this
Ligand-Target Pair
Casein kinase I Epsilon


(Homo sapiens (Human))
BDBM274752
PNG
(N-(6-(4-(4-fluorophenyl)-1,2- dimethyl-1H-imidazol...)
Show SMILES Cc1nc(c(-c2ccc3nc(NC(=O)c4cccc5ncccc45)cn3n2)n1C)-c1ccc(F)cc1
Show InChI InChI=1S/C27H20FN7O/c1-16-30-25(17-8-10-18(28)11-9-17)26(34(16)2)22-12-13-24-31-23(15-35(24)33-22)32-27(36)20-5-3-7-21-19(20)6-4-14-29-21/h3-15H,1-2H3,(H,32,36)
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Bristol-Myers Squibb Company

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Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)

More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM274752
PNG
(N-(6-(4-(4-fluorophenyl)-1,2- dimethyl-1H-imidazol...)
Show SMILES Cc1nc(c(-c2ccc3nc(NC(=O)c4cccc5ncccc45)cn3n2)n1C)-c1ccc(F)cc1
Show InChI InChI=1S/C27H20FN7O/c1-16-30-25(17-8-10-18(28)11-9-17)26(34(16)2)22-12-13-24-31-23(15-35(24)33-22)32-27(36)20-5-3-7-21-19(20)6-4-14-29-21/h3-15H,1-2H3,(H,32,36)
PDB

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Bristol-Myers Squibb Company

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Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)

More data for this
Ligand-Target Pair
Casein kinase I Epsilon


(Homo sapiens (Human))
BDBM274752
PNG
(N-(6-(4-(4-fluorophenyl)-1,2- dimethyl-1H-imidazol...)
Show SMILES Cc1nc(c(-c2ccc3nc(NC(=O)c4cccc5ncccc45)cn3n2)n1C)-c1ccc(F)cc1
Show InChI InChI=1S/C27H20FN7O/c1-16-30-25(17-8-10-18(28)11-9-17)26(34(16)2)22-12-13-24-31-23(15-35(24)33-22)32-27(36)20-5-3-7-21-19(20)6-4-14-29-21/h3-15H,1-2H3,(H,32,36)
PDB

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Bristol-Myers Squibb Company

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Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)

More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM274752
PNG
(N-(6-(4-(4-fluorophenyl)-1,2- dimethyl-1H-imidazol...)
Show SMILES Cc1nc(c(-c2ccc3nc(NC(=O)c4cccc5ncccc45)cn3n2)n1C)-c1ccc(F)cc1
Show InChI InChI=1S/C27H20FN7O/c1-16-30-25(17-8-10-18(28)11-9-17)26(34(16)2)22-12-13-24-31-23(15-35(24)33-22)32-27(36)20-5-3-7-21-19(20)6-4-14-29-21/h3-15H,1-2H3,(H,32,36)
PDB

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Bristol-Myers Squibb Company

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Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)

More data for this
Ligand-Target Pair
Casein kinase I Epsilon


(Homo sapiens (Human))
BDBM274753
PNG
(5-(4-chlorophenyl)-N-(6-(4- (4-fluorophenyl)-1,2-d...)
Show SMILES Cc1nc(c(-c2ccc3nc(NC(=O)c4ccc([nH]4)-c4ccc(Cl)cc4)cn3n2)n1C)-c1ccc(F)cc1
Show InChI InChI=1S/C28H21ClFN7O/c1-16-31-26(18-5-9-20(30)10-6-18)27(36(16)2)22-13-14-25-33-24(15-37(25)35-22)34-28(38)23-12-11-21(32-23)17-3-7-19(29)8-4-17/h3-15,32H,1-2H3,(H,34,38)
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Bristol-Myers Squibb Company

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Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)

More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM274753
PNG
(5-(4-chlorophenyl)-N-(6-(4- (4-fluorophenyl)-1,2-d...)
Show SMILES Cc1nc(c(-c2ccc3nc(NC(=O)c4ccc([nH]4)-c4ccc(Cl)cc4)cn3n2)n1C)-c1ccc(F)cc1
Show InChI InChI=1S/C28H21ClFN7O/c1-16-31-26(18-5-9-20(30)10-6-18)27(36(16)2)22-13-14-25-33-24(15-37(25)35-22)34-28(38)23-12-11-21(32-23)17-3-7-19(29)8-4-17/h3-15,32H,1-2H3,(H,34,38)
PDB

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Bristol-Myers Squibb Company

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Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)

More data for this
Ligand-Target Pair
Casein kinase I Epsilon


(Homo sapiens (Human))
BDBM274754
PNG
(N-(6-(4-(4-fluorophenyl)-1,2- dimethyl-1H-imidazol...)
Show SMILES Cc1nc(c(-c2ccc3nc(NC(=O)c4cccc5cnccc45)cn3n2)n1C)-c1ccc(F)cc1
Show InChI InChI=1S/C27H20FN7O/c1-16-30-25(17-6-8-19(28)9-7-17)26(34(16)2)22-10-11-24-31-23(15-35(24)33-22)32-27(36)21-5-3-4-18-14-29-13-12-20(18)21/h3-15H,1-2H3,(H,32,36)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)

More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM274754
PNG
(N-(6-(4-(4-fluorophenyl)-1,2- dimethyl-1H-imidazol...)
Show SMILES Cc1nc(c(-c2ccc3nc(NC(=O)c4cccc5cnccc45)cn3n2)n1C)-c1ccc(F)cc1
Show InChI InChI=1S/C27H20FN7O/c1-16-30-25(17-6-8-19(28)9-7-17)26(34(16)2)22-10-11-24-31-23(15-35(24)33-22)32-27(36)21-5-3-4-18-14-29-13-12-20(18)21/h3-15H,1-2H3,(H,32,36)
PDB

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Bristol-Myers Squibb Company

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Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)

More data for this
Ligand-Target Pair
Casein kinase I Epsilon


(Homo sapiens (Human))
BDBM274755
PNG
(N-(6-(4-(4-fluorophenyl)-1,2- dimethyl-1H-imidazol...)
Show SMILES Cc1nc(c(-c2ccc3nc(NC(=O)c4cccc5ccncc45)cn3n2)n1C)-c1ccc(F)cc1
Show InChI InChI=1S/C27H20FN7O/c1-16-30-25(18-6-8-19(28)9-7-18)26(34(16)2)22-10-11-24-31-23(15-35(24)33-22)32-27(36)20-5-3-4-17-12-13-29-14-21(17)20/h3-15H,1-2H3,(H,32,36)
PDB

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Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)

More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM274755
PNG
(N-(6-(4-(4-fluorophenyl)-1,2- dimethyl-1H-imidazol...)
Show SMILES Cc1nc(c(-c2ccc3nc(NC(=O)c4cccc5ccncc45)cn3n2)n1C)-c1ccc(F)cc1
Show InChI InChI=1S/C27H20FN7O/c1-16-30-25(18-6-8-19(28)9-7-18)26(34(16)2)22-10-11-24-31-23(15-35(24)33-22)32-27(36)20-5-3-4-17-12-13-29-14-21(17)20/h3-15H,1-2H3,(H,32,36)
PDB

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Bristol-Myers Squibb Company

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Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)

More data for this
Ligand-Target Pair
Casein kinase I Epsilon


(Homo sapiens (Human))
BDBM274756
PNG
(6-fluoro-N-(6-(4-(4-fluoro- phenyl)-1,2-dimethyl-1...)
Show SMILES Cc1nc(c(-c2ccc3nc(NC(=O)c4cc5ccc(F)cc5[nH]4)cn3n2)n1C)-c1ccc(F)cc1
Show InChI InChI=1S/C26H19F2N7O/c1-14-29-24(15-3-6-17(27)7-4-15)25(34(14)2)19-9-10-23-31-22(13-35(23)33-19)32-26(36)21-11-16-5-8-18(28)12-20(16)30-21/h3-13,30H,1-2H3,(H,32,36)
PDB

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Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)

More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM274756
PNG
(6-fluoro-N-(6-(4-(4-fluoro- phenyl)-1,2-dimethyl-1...)
Show SMILES Cc1nc(c(-c2ccc3nc(NC(=O)c4cc5ccc(F)cc5[nH]4)cn3n2)n1C)-c1ccc(F)cc1
Show InChI InChI=1S/C26H19F2N7O/c1-14-29-24(15-3-6-17(27)7-4-15)25(34(14)2)19-9-10-23-31-22(13-35(23)33-19)32-26(36)21-11-16-5-8-18(28)12-20(16)30-21/h3-13,30H,1-2H3,(H,32,36)
PDB

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Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)

More data for this
Ligand-Target Pair
Casein kinase I Epsilon


(Homo sapiens (Human))
BDBM274757
PNG
(N-(6-(4-(4-fluorophenyl)-1,2- dimethyl-1H-imidazol...)
Show SMILES Cc1nc(c(-c2ccc3nc(NC(=O)c4ccc([nH]4)-c4ccccc4)cn3n2)n1C)-c1ccc(F)cc1
Show InChI InChI=1S/C28H22FN7O/c1-17-30-26(19-8-10-20(29)11-9-19)27(35(17)2)22-14-15-25-32-24(16-36(25)34-22)33-28(37)23-13-12-21(31-23)18-6-4-3-5-7-18/h3-16,31H,1-2H3,(H,33,37)
PDB

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Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)

More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM274757
PNG
(N-(6-(4-(4-fluorophenyl)-1,2- dimethyl-1H-imidazol...)
Show SMILES Cc1nc(c(-c2ccc3nc(NC(=O)c4ccc([nH]4)-c4ccccc4)cn3n2)n1C)-c1ccc(F)cc1
Show InChI InChI=1S/C28H22FN7O/c1-17-30-26(19-8-10-20(29)11-9-19)27(35(17)2)22-14-15-25-32-24(16-36(25)34-22)33-28(37)23-13-12-21(31-23)18-6-4-3-5-7-18/h3-16,31H,1-2H3,(H,33,37)
PDB

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Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)

More data for this
Ligand-Target Pair
Casein kinase I Epsilon


(Homo sapiens (Human))
BDBM274758
PNG
(N-(6-(4-(4-fluorophenyl)-1,2- dimethyl-1H-imidazol...)
Show SMILES Cc1nc(c(-c2ccc3nc(NC(=O)C4=CCc5ccncc45)cn3n2)n1C)-c1ccc(F)cc1
Show InChI InChI=1S/C26H20FN7O/c1-15-29-24(17-3-6-18(27)7-4-17)25(33(15)2)21-9-10-23-30-22(14-34(23)32-21)31-26(35)19-8-5-16-11-12-28-13-20(16)19/h3-4,6-14H,5H2,1-2H3,(H,31,35)
PDB

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Bristol-Myers Squibb Company

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Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)

More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM274758
PNG
(N-(6-(4-(4-fluorophenyl)-1,2- dimethyl-1H-imidazol...)
Show SMILES Cc1nc(c(-c2ccc3nc(NC(=O)C4=CCc5ccncc45)cn3n2)n1C)-c1ccc(F)cc1
Show InChI InChI=1S/C26H20FN7O/c1-15-29-24(17-3-6-18(27)7-4-17)25(33(15)2)21-9-10-23-30-22(14-34(23)32-21)31-26(35)19-8-5-16-11-12-28-13-20(16)19/h3-4,6-14H,5H2,1-2H3,(H,31,35)
PDB

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Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)

More data for this
Ligand-Target Pair
Casein kinase I Epsilon


(Homo sapiens (Human))
BDBM274759
PNG
(N-(6-(4-(4-fluorophenyl)-1,2- dimethyl-1H-imidazol...)
Show SMILES Cc1nc(c(-c2ccc3nc(NC(=O)c4ccns4)cn3n2)n1C)-c1ccc(F)cc1
Show InChI InChI=1S/C21H16FN7OS/c1-12-24-19(13-3-5-14(22)6-4-13)20(28(12)2)15-7-8-18-25-17(11-29(18)27-15)26-21(30)16-9-10-23-31-16/h3-11H,1-2H3,(H,26,30)
PDB

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Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)

More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM274759
PNG
(N-(6-(4-(4-fluorophenyl)-1,2- dimethyl-1H-imidazol...)
Show SMILES Cc1nc(c(-c2ccc3nc(NC(=O)c4ccns4)cn3n2)n1C)-c1ccc(F)cc1
Show InChI InChI=1S/C21H16FN7OS/c1-12-24-19(13-3-5-14(22)6-4-13)20(28(12)2)15-7-8-18-25-17(11-29(18)27-15)26-21(30)16-9-10-23-31-16/h3-11H,1-2H3,(H,26,30)
PDB

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Bristol-Myers Squibb Company

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Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)

More data for this
Ligand-Target Pair
Casein kinase I Epsilon


(Homo sapiens (Human))
BDBM274760
PNG
(N-(6-(4-(4-fluorophenyl)-1,2- dimethyl-1H-imidazol...)
Show SMILES Cc1nc(c(-c2ccc3nc(NC(=O)c4ccc5ncccc5c4)cn3n2)n1C)-c1ccc(F)cc1
Show InChI InChI=1S/C27H20FN7O/c1-16-30-25(17-5-8-20(28)9-6-17)26(34(16)2)22-11-12-24-31-23(15-35(24)33-22)32-27(36)19-7-10-21-18(14-19)4-3-13-29-21/h3-15H,1-2H3,(H,32,36)
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Bristol-Myers Squibb Company

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Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)

More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM274760
PNG
(N-(6-(4-(4-fluorophenyl)-1,2- dimethyl-1H-imidazol...)
Show SMILES Cc1nc(c(-c2ccc3nc(NC(=O)c4ccc5ncccc5c4)cn3n2)n1C)-c1ccc(F)cc1
Show InChI InChI=1S/C27H20FN7O/c1-16-30-25(17-5-8-20(28)9-6-17)26(34(16)2)22-11-12-24-31-23(15-35(24)33-22)32-27(36)19-7-10-21-18(14-19)4-3-13-29-21/h3-15H,1-2H3,(H,32,36)
PDB

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n/an/a 0.507n/an/an/an/a7.425



Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)

More data for this
Ligand-Target Pair
Casein kinase I Epsilon


(Homo sapiens (Human))
BDBM274761
PNG
(N-(6-(4-(4-fluorophenyl)-1,2- dimethyl-1H-imidazol...)
Show SMILES Cc1nc(c(-c2ccc3nc(NC(=O)c4ccc5cccnc5c4)cn3n2)n1C)-c1ccc(F)cc1
Show InChI InChI=1S/C27H20FN7O/c1-16-30-25(18-7-9-20(28)10-8-18)26(34(16)2)21-11-12-24-31-23(15-35(24)33-21)32-27(36)19-6-5-17-4-3-13-29-22(17)14-19/h3-15H,1-2H3,(H,32,36)
PDB

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n/an/a 2.58n/an/an/an/a7.425



Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)

More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM274761
PNG
(N-(6-(4-(4-fluorophenyl)-1,2- dimethyl-1H-imidazol...)
Show SMILES Cc1nc(c(-c2ccc3nc(NC(=O)c4ccc5cccnc5c4)cn3n2)n1C)-c1ccc(F)cc1
Show InChI InChI=1S/C27H20FN7O/c1-16-30-25(18-7-9-20(28)10-8-18)26(34(16)2)21-11-12-24-31-23(15-35(24)33-21)32-27(36)19-6-5-17-4-3-13-29-22(17)14-19/h3-15H,1-2H3,(H,32,36)
PDB

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n/an/a 0.271n/an/an/an/a7.425



Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)

More data for this
Ligand-Target Pair
Casein kinase I Epsilon


(Homo sapiens (Human))
BDBM274762
PNG
(N-(6-(4-(4-fluorophenyl)-1,2- dimethyl-1H-imidazol...)
Show SMILES Cc1c[nH]c(c1)C(=O)Nc1cn2nc(ccc2n1)-c1c(nc(C)n1C)-c1ccc(F)cc1
Show InChI InChI=1S/C23H20FN7O/c1-13-10-18(25-11-13)23(32)28-19-12-31-20(27-19)9-8-17(29-31)22-21(26-14(2)30(22)3)15-4-6-16(24)7-5-15/h4-12,25H,1-3H3,(H,28,32)
PDB

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n/an/a 0.768n/an/an/an/a7.425



Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)

More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM274762
PNG
(N-(6-(4-(4-fluorophenyl)-1,2- dimethyl-1H-imidazol...)
Show SMILES Cc1c[nH]c(c1)C(=O)Nc1cn2nc(ccc2n1)-c1c(nc(C)n1C)-c1ccc(F)cc1
Show InChI InChI=1S/C23H20FN7O/c1-13-10-18(25-11-13)23(32)28-19-12-31-20(27-19)9-8-17(29-31)22-21(26-14(2)30(22)3)15-4-6-16(24)7-5-15/h4-12,25H,1-3H3,(H,28,32)
PDB

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n/an/a 0.368n/an/an/an/a7.425



Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)

More data for this
Ligand-Target Pair
Casein kinase I Epsilon


(Homo sapiens (Human))
BDBM274763
PNG
(N-(6-(4-(4-fluorophenyl)-1,2- dimethyl-1H-imidazol...)
Show SMILES Cc1nc(c(-c2ccc3nc(NC(=O)c4ccc5cnccc5c4)cn3n2)n1C)-c1ccc(F)cc1
Show InChI InChI=1S/C27H20FN7O/c1-16-30-25(17-5-7-21(28)8-6-17)26(34(16)2)22-9-10-24-31-23(15-35(24)33-22)32-27(36)19-3-4-20-14-29-12-11-18(20)13-19/h3-15H,1-2H3,(H,32,36)
PDB

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n/an/a 1.61n/an/an/an/a7.425



Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)

More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM274763
PNG
(N-(6-(4-(4-fluorophenyl)-1,2- dimethyl-1H-imidazol...)
Show SMILES Cc1nc(c(-c2ccc3nc(NC(=O)c4ccc5cnccc5c4)cn3n2)n1C)-c1ccc(F)cc1
Show InChI InChI=1S/C27H20FN7O/c1-16-30-25(17-5-7-21(28)8-6-17)26(34(16)2)22-9-10-24-31-23(15-35(24)33-22)32-27(36)19-3-4-20-14-29-12-11-18(20)13-19/h3-15H,1-2H3,(H,32,36)
PDB

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n/an/a 0.187n/an/an/an/a7.425



Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)

More data for this
Ligand-Target Pair
Casein kinase I Epsilon


(Homo sapiens (Human))
BDBM274764
PNG
(N-(6-(4-(4-fluorophenyl)-1,2- dimethyl-1H-imidazol...)
Show SMILES Cc1nc(c(-c2ccc3nc(NC(=O)c4snnc4-c4ccccc4)cn3n2)n1C)-c1ccc(F)cc1
Show InChI InChI=1S/C26H19FN8OS/c1-15-28-22(17-8-10-18(27)11-9-17)24(34(15)2)19-12-13-21-29-20(14-35(21)32-19)30-26(36)25-23(31-33-37-25)16-6-4-3-5-7-16/h3-14H,1-2H3,(H,30,36)
PDB

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Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)

More data for this
Ligand-Target Pair
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